Faculty Collaboration Database

Owen Griffith PhD

Emeritus Professor

Institution: Medical College of Wisconsin
Department: Biochemistry

Publications (139)

Crystallization and preliminary crystallographic analysis of bifunctional gamma-glutamylcysteine synthetase-glutatione synthetase from Streptococcus agalactiae. (Nakashima Y, Nii H, Janowiak BE, Griffith OW, Hibi T) Acta Crystallogr Sect F Struct Biol Cryst Commun 2009 Jul 01;65(Pt 7):678-80 PMID: 19574637 PMCID: PMC2705632 SCOPUS ID: 2-s2.0-68149091453 07/04/2009 6 Citations

Metabolic profiling of arginine and nitric oxide pathways predicts hemodynamic abnormalities and mortality in patients with cardiogenic shock after acute myocardial infarction. (Nicholls SJ, Wang Z, Koeth R, Levison B, DelFraino B, Dzavik V, Griffith OW, Hathaway D, Panza JA, Nissen SE, Hochman JS, Hazen SL) Circulation 2007 Nov 13;116(20):2315-24 PMID: 17967979 SCOPUS ID: 2-s2.0-36048946363 10/31/2007 90 Citations

Gamma-glutamylcysteine synthetase-glutathione synthetase: domain structure and identification of residues important in substrate and glutathione binding. (Janowiak BE, Hayward MA, Peterson FC, Volkman BF, Griffith OW) Biochemistry 2006 Sep 05;45(35):10461-73 PMID: 16939198 SCOPUS ID: 2-s2.0-33748256537 08/31/2006 32 Citations

Post-translational modification of manganese superoxide dismutase in acutely rejecting cardiac transplants: role of inducible nitric oxide synthase. (Nilakantan V, Halligan NL, Nguyen TK, Hilton G, Khanna AK, Roza AM, Johnson CP, Adams MB, Griffith OW, Pieper GM) J Heart Lung Transplant 2005 Oct;24(10):1591-9 PMID: 16210135 SCOPUS ID: 2-s2.0-25844454887 10/08/2005 35 Citations

Glutathione synthesis in Streptococcus agalactiae. One protein accounts for gamma-glutamylcysteine synthetase and glutathione synthetase activities. (Janowiak BE, Griffith OW) J Biol Chem 2005 Mar 25;280(12):11829-39 PMID: 15642737 SCOPUS ID: 2-s2.0-15744398210 01/12/2005 113 Citations

Variable efficacy of N6-(1-iminoethyl)-L-lysine in acute cardiac transplant rejection. (Pieper GM, Nilakantan V, Hilton G, Zhou X, Khanna AK, Halligan NL, Felix CC, Kampalath B, Griffith OW, Hayward MA, Roza AM, Adams MB) Am J Physiol Heart Circ Physiol 2004 Feb;286(2):H525-34 PMID: 14715498 SCOPUS ID: 2-s2.0-19244374793 01/13/2004 8 Citations

Structural characterization and kinetics of nitric-oxide synthase inhibition by novel N5-(iminoalkyl)- and N5-(iminoalkenyl)-ornithines. (Bretscher LE, Li H, Poulos TL, Griffith OW) J Biol Chem 2003 Nov 21;278(47):46789-97 PMID: 12960153 SCOPUS ID: 2-s2.0-0344875548 09/10/2003 40 Citations

Non-heme iron protein: a potential target of nitric oxide in acute cardiac allograft rejection. (Pieper GM, Halligan NL, Hilton G, Konorev EA, Felix CC, Roza AM, Adams MB, Griffith OW) Proc Natl Acad Sci U S A 2003 Mar 18;100(6):3125-30 PMID: 12624190 PMCID: PMC152257 SCOPUS ID: 2-s2.0-0037453062 03/08/2003 32 Citations

Glutaminase and the control of airway pH: yet another problem for the asthmatic lung? (Griffith OW) Am J Respir Crit Care Med 2002 Jan 01;165(1):1-2 PMID: 11779720 SCOPUS ID: 2-s2.0-0036143971 01/10/2002 9 Citations

Escherichia coli gamma-glutamylcysteine synthetase. Two active site metal ions affect substrate and inhibitor binding. (Kelly BS, Antholine WE, Griffith OW) J Biol Chem 2002 Jan 04;277(1):50-8 PMID: 11675389 SCOPUS ID: 2-s2.0-0037016697 10/25/2001 53 Citations

In vivo proton (H1) magnetic resonance spectroscopy for cervical carcinoma. (Allen JR, Prost RW, Griffith OW, Erickson SJ, Erickson BA) Am J Clin Oncol 2001 Oct;24(5):522-9 PMID: 11586108 SCOPUS ID: 2-s2.0-0034787934 10/05/2001 48 Citations

Implications for isoform-selective inhibitor design derived from the binding mode of bulky isothioureas to the heme domain of endothelial nitric-oxide synthase. (Raman CS, Li H, Martásek P, Babu BR, Griffith OW, Masters BS, Poulos TL) J Biol Chem 2001 Jul 13;276(28):26486-91 PMID: 11331290 SCOPUS ID: 2-s2.0-0035854721 05/02/2001 27 Citations

Chronic myocardial hypoxia increases nitric oxide synthase and decreases caveolin-3. (Shi Y, Pritchard KA Jr, Holman P, Rafiee P, Griffith OW, Kalyanaraman B, Baker JE) Free Radic Biol Med 2000 Oct 15;29(8):695-703 PMID: 11053770 SCOPUS ID: 2-s2.0-0034667740 10/29/2000 63 Citations

Strategies to reduce side effects of interleukin-2: evaluation of the antihypotensive agent NG-monomethyl-L-arginine. (Kilbourn RG, Fonseca GA, Trissel LA, Griffith OW) Cancer J Sci Am 2000 Feb;6 Suppl 1:S21-30 PMID: 10685654 SCOPUS ID: 2-s2.0-0033844391 02/24/2000 30 Citations

Biologic and pharmacologic regulation of mammalian glutathione synthesis. (Griffith OW) Free Radic Biol Med 1999 Nov;27(9-10):922-35 PMID: 10569625 SCOPUS ID: 2-s2.0-0033231162 11/24/1999 1075 Citations

L-arginine binding to nitric-oxide synthase. The role of H-bonds to the nonreactive guanidinium nitrogens. (Babu BR, Frey C, Griffith OW) J Biol Chem 1999 Sep 03;274(36):25218-26 PMID: 10464242 SCOPUS ID: 2-s2.0-0033520402 08/28/1999 55 Citations

Adaptation to chronic hypoxia confers tolerance to subsequent myocardial ischemia by increased nitric oxide production. (Baker JE, Holman P, Kalyanaraman B, Griffith OW, Pritchard KA Jr) Ann N Y Acad Sci 1999 Jun 30;874:236-53 PMID: 10415535 SCOPUS ID: 2-s2.0-0032773216 07/23/1999 63 Citations

The enzymes of glutathione synthesis: gamma-glutamylcysteine synthetase. (Griffith OW, Mulcahy RT) Adv Enzymol Relat Areas Mol Biol 1999;73:209-67, xii PMID: 10218110 SCOPUS ID: 2-s2.0-0032617250 04/28/1999 247 Citations

Design of isoform-selective inhibitors of nitric oxide synthase. (Babu BR, Griffith OW) Curr Opin Chem Biol 1998 Aug;2(4):491-500 PMID: 9736922 SCOPUS ID: 2-s2.0-0032133353 09/16/1998 134 Citations

Expression and purification of human gamma-glutamylcysteine synthetase. (Misra I, Griffith OW) Protein Expr Purif 1998 Jul;13(2):268-76 PMID: 9675072 SCOPUS ID: 2-s2.0-0032126145 07/24/1998 56 Citations

N5-(1-Imino-3-butenyl)-L-ornithine. A neuronal isoform selective mechanism-based inactivator of nitric oxide synthase. (Babu BR, Griffith OW) J Biol Chem 1998 Apr 10;273(15):8882-9 PMID: 9535869 SCOPUS ID: 2-s2.0-0032502351 05/16/1998 119 Citations

Characterization of 5-oxo-L-prolinase in normal and tumor tissues of humans and rats: a potential new target for biochemical modulation of glutathione. (Chen X, Schecter RL, Griffith OW, Hayward MA, Alpert LC, Batist G) Clin Cancer Res 1998 Jan;4(1):131-8 PMID: 9516961 SCOPUS ID: 2-s2.0-0031930635 05/14/1998 24 Citations

Measurements of total plasma nitrite and nitrate in pediatric patients with the systemic inflammatory response syndrome. (Spack L, Havens PL, Griffith OW) Crit Care Med 1997 Jun;25(6):1071-8 PMID: 9201063 SCOPUS ID: 2-s2.0-0030940321 06/01/1997 47 Citations

Inhibition of endothelial cell amino acid transport System y+ by arginine analogs that inhibit nitric oxide synthase. (McDonald KK, Rouhani R, Handlogten ME, Block ER, Griffith OW, Allison RD, Kilberg MS) Biochim Biophys Acta 1997 Feb 21;1324(1):133-41 PMID: 9059506 SCOPUS ID: 2-s2.0-0031057320 02/21/1997 28 Citations

L-amino acid oxidase (LOX) modulation of melphalan activity against intracranial glioma. (Moynihan K, Elion GB, Pegram C, Reist CJ, Wellner D, Bigner DD, Griffith OW, Friedman HS) Cancer Chemother Pharmacol 1997;39(3):179-86 PMID: 8996517 SCOPUS ID: 2-s2.0-0031060432 01/01/1997 7 Citations

Design of nitric oxide synthase inhibitors and their use to reverse hypotension associated with cancer immunotherapy. (Griffith OW, Kilbourn RG) Adv Enzyme Regul 1997;37:171-94 PMID: 9381971 SCOPUS ID: 2-s2.0-0030752552 01/01/1997 12 Citations

Characterization of the mechanisms of busulfan resistance in a human glioblastoma multiforme xenograft. (Hare CB, Elion GB, Colvin OM, Ali-Osman F, Griffith OW, Petros WP, Keir S, Marcelli SL, Bigner DD, Friedman HS) Cancer Chemother Pharmacol 1997;40(5):409-14 PMID: 9272117 SCOPUS ID: 2-s2.0-8544277976 01/01/1997 4 Citations

NO in septic shock: good, bad or ugly? Learning from iNOS knockouts. (Gross SS, Kilbourn RG, Griffith OW) Trends Microbiol 1996 Feb;4(2):47-9 PMID: 8820564 SCOPUS ID: 2-s2.0-0029872254 02/01/1996 24 Citations

Nitric oxide synthase inhibitors: amino acids. (Griffith OW, Kilbourn RG) Methods Enzymol 1996;268:375-92 PMID: 8782604 SCOPUS ID: 2-s2.0-0029795296 01/01/1996 102 Citations

Characterization by electron paramagnetic resonance of the interactions of L-arginine and L-thiocitrulline with the heme cofactor region of nitric oxide synthase. (Salerno JC, Frey C, McMillan K, Williams RF, Masters BS, Griffith OW) J Biol Chem 1995 Nov 17;270(46):27423-8 PMID: 7499198 SCOPUS ID: 2-s2.0-0028802346 11/17/1995 57 Citations

Pulmonary oxygen toxicity in mice is characterized by alterations in ascorbate redox status. (Rusakow LS, Han J, Hayward MA, Griffith OW) J Appl Physiol (1985) 1995 Nov;79(5):1769-76 PMID: 8594040 SCOPUS ID: 2-s2.0-0028871722 11/01/1995 7 Citations

Characterization of the effects of two new arginine/citrulline analogues on constitutive and inducible nitric oxide synthases in rat aorta. (Joly GA, Narayanan K, Griffith OW, Kilbourn RG) Br J Pharmacol 1995 Jun;115(3):491-7 PMID: 7582462 PMCID: PMC1908423 SCOPUS ID: 2-s2.0-0029020310 06/01/1995 11 Citations

NG-methyl-L-arginine, an inhibitor of nitric oxide synthase, reverses interleukin-2-induced hypotension. (Kilbourn RG, Fonseca GA, Griffith OW, Ewer M, Price K, Striegel A, Jones E, Logothetis CJ) Crit Care Med 1995 Jun;23(6):1018-24 PMID: 7774211 SCOPUS ID: 2-s2.0-0028989755 06/01/1995 59 Citations

S-alkyl-L-thiocitrullines. Potent stereoselective inhibitors of nitric oxide synthase with strong pressor activity in vivo. (Narayanan K, Spack L, McMillan K, Kilbourn RG, Hayward MA, Masters BS, Griffith OW) J Biol Chem 1995 May 12;270(19):11103-10 PMID: 7538112 SCOPUS ID: 2-s2.0-0029078058 05/12/1995 79 Citations

Nitric oxide synthases: properties and catalytic mechanism. (Griffith OW, Stuehr DJ) Annu Rev Physiol 1995;57:707-36 PMID: 7539994 SCOPUS ID: 2-s2.0-0028902552 01/01/1995 1245 Citations

The effect of L-amino acid oxidase on activity of melphalan against an intracranial xenograft. (Rich JN, Elion GB, Wellner D, Colvin OM, Groothuis DR, Hilton JH, Schlageter KE, Bigner DD, Griffith OW, Friedman HS) Cancer Chemother Pharmacol 1995;36(5):379-84 PMID: 7634379 SCOPUS ID: 2-s2.0-0028984049 01/01/1995 5 Citations

NG-methyl-L-arginine, an inhibitor of nitric oxide formation, acts synergistically with dobutamine to improve cardiovascular performance in endotoxemic dogs. (Kilbourn RG, Cromeens DM, Chelly FD, Griffith OW) Crit Care Med 1994 Nov;22(11):1835-40 PMID: 7956289 SCOPUS ID: 2-s2.0-0028172161 11/01/1994 43 Citations

L-thiocitrulline. A stereospecific, heme-binding inhibitor of nitric-oxide synthases. (Frey C, Narayanan K, McMillan K, Spack L, Gross SS, Masters BS, Griffith OW) J Biol Chem 1994 Oct 21;269(42):26083-91 PMID: 7523401 SCOPUS ID: 2-s2.0-0028172940 10/21/1994 108 Citations

Inhibition of nitric oxide production is associated with enhanced weight loss, decreased survival, and impaired alloengraftment in mice undergoing graft-versus-host disease after bone marrow transplantation. (Drobyski WR, Keever CA, Hanson GA, McAuliffe T, Griffith OW) Blood 1994 Oct 01;84(7):2363-73 PMID: 7522627 SCOPUS ID: 2-s2.0-0027965550 10/01/1994 41 Citations

Elevated DNA polymerase alpha, DNA polymerase beta, and DNA topoisomerase II in a melphalan-resistant rhabdomyosarcoma xenograft that is cross-resistant to nitrosoureas and topotecan. (Friedman HS, Dolan ME, Kaufmann SH, Colvin OM, Griffith OW, Moschel RC, Schold SC, Bigner DD, Ali-Osman F) Cancer Res 1994 Jul 01;54(13):3487-93 PMID: 8012971 SCOPUS ID: 2-s2.0-0028228297 07/01/1994 54 Citations

Pharmacodynamics of prolonged treatment with L,S-buthionine sulfoximine. (Malaker K, Hurwitz SJ, Bump EA, Griffith OW, Lai LL, Riese N, Coleman CN) Int J Radiat Oncol Biol Phys 1994 May 15;29(2):407-12 PMID: 7910818 SCOPUS ID: 2-s2.0-0028342470 05/15/1994 11 Citations

Synthesis of L-thiocitrulline, L-homothiocitrulline, and S-methyl-L-thiocitrulline: a new class of potent nitric oxide synthase inhibitors. (Narayanan K, Griffith OW) J Med Chem 1994 Apr 01;37(7):885-7 PMID: 7512141 SCOPUS ID: 2-s2.0-0028314083 04/01/1994 122 Citations

NG-methyl-L-arginine, an inhibitor of nitric oxide formation, reverses IL-2-mediated hypotension in dogs. (Kilbourn RG, Owen-Schaub LB, Cromeens DM, Gross SS, Flaherty MJ, Santee SM, Alak AM, Griffith OW) J Appl Physiol (1985) 1994 Mar;76(3):1130-7 PMID: 8005855 SCOPUS ID: 2-s2.0-0028180766 03/01/1994 44 Citations

Pathogenetic mechanisms of septic shock. (Kilbourn RG, Griffith OW, Gross SS) N Engl J Med 1993 Nov 04;329(19):1427-8 PMID: 7692299 SCOPUS ID: 2-s2.0-0027430202 11/04/1993 20 Citations

Oxy radicals and antioxidative responses in cancer: 12th Sapporo Cancer Seminar. (Taniguchi N, Pickett CB, Griffith OW) Cancer Res 1993 Jul 01;53(13):3207-10 PMID: 8100484 SCOPUS ID: 2-s2.0-0027249188 07/01/1993 12 Citations

Cardiac cell toxicity induced by 4-hydroperoxycyclophosphamide is modulated by glutathione. (Levine ES, Friedman HS, Griffith OW, Colvin OM, Raynor JH, Lieberman M) Cardiovasc Res 1993 Jul;27(7):1248-53 PMID: 8252585 SCOPUS ID: 2-s2.0-0027169880 07/01/1993 32 Citations

Irreversible inactivation of macrophage and brain nitric oxide synthase by L-NG-methylarginine requires NADPH-dependent hydroxylation. (Feldman PL, Griffith OW, Hong H, Stuehr DJ) J Med Chem 1993 Feb 19;36(4):491-6 PMID: 7682617 SCOPUS ID: 2-s2.0-0027458692 02/19/1993 126 Citations

Glutathione ester delays the onset of scurvy in ascorbate-deficient guinea pigs. (Mårtensson J, Han J, Griffith OW, Meister A) Proc Natl Acad Sci U S A 1993 Jan 01;90(1):317-21 PMID: 8419936 PMCID: PMC45651 SCOPUS ID: 2-s2.0-0027439589 01/01/1993 101 Citations

Development of a model of melphalan-induced gastrointestinal toxicity in mice. (Castellino S, Elion GB, Griffith OW, Dewhirst M, Kurtzberg J, Cattley RC, Scott P, Bigner DD, Friedman HS) Cancer Chemother Pharmacol 1993;31(5):376-80 PMID: 8431971 SCOPUS ID: 2-s2.0-0027399247 01/01/1993 12 Citations

Inhibition of inducible nitric oxide synthase with inhibitors of tetrahydrobiopterin biosynthesis. (Kilbourn RG, Griffith OW) J Natl Cancer Inst 1992 Nov 04;84(21):1672 PMID: 1279185 SCOPUS ID: 2-s2.0-0026486937 11/04/1992 9 Citations

Cyclophosphamide resistance in medulloblastoma. (Friedman HS, Colvin OM, Kaufmann SH, Ludeman SM, Bullock N, Bigner DD, Griffith OW) Cancer Res 1992 Oct 01;52(19):5373-8 PMID: 1356617 SCOPUS ID: 2-s2.0-0026644834 10/01/1992 79 Citations

Inhibition of interleukin-1-alpha-induced nitric oxide synthase in vascular smooth muscle and full reversal of interleukin-1-alpha-induced hypotension by N omega-amino-L-arginine. (Kilbourn RG, Gross SS, Lodato RF, Adams J, Levi R, Miller LL, Lachman LB, Griffith OW) J Natl Cancer Inst 1992 Jul 01;84(13):1008-16 PMID: 1376778 SCOPUS ID: 2-s2.0-0026762484 07/01/1992 69 Citations

Overproduction of nitric oxide in cytokine-mediated and septic shock. (Kilbourn RG, Griffith OW) J Natl Cancer Inst 1992 Jun 03;84(11):827-31 PMID: 1375655 SCOPUS ID: 2-s2.0-0026741759 06/03/1992 270 Citations

Effects of glutathione or polyamine depletion on in vivo thermosensitization. (Laskowitz DT, Elion GB, Dewhirst MW, Griffith OW, Casero RA Jr, Scott PA, Bullock N, Bigner DD, Friedman HS) Int J Hyperthermia 1992;8(2):199-208 PMID: 1573309 SCOPUS ID: 2-s2.0-0026548547 03/11/1992 1 Citation

Hyperthermia-induced enhancement of melphalan activity against a melphalan-resistant human rhabdomyosarcoma xenograft. (Laskowitz DT, Elion GB, Dewhirst MW, Griffith OW, Savina PM, Blum MR, Prescott DM, Bigner DD, Friedman HS) Radiat Res 1992 Feb;129(2):218-23 PMID: 1734453 SCOPUS ID: 2-s2.0-0026607730 02/01/1992 16 Citations

Enhancement of melphalan-induced gastrointestinal toxicity in mice treated with regional hyperthermia and BSO-mediated glutathione depletion. (Laskowitz DT, Elion GB, Dewhirst MW, Griffith OW, Cattley RC, Bigner DD, Friedman HS) Int J Hyperthermia 1992;8(1):111-20 PMID: 1545157 SCOPUS ID: 2-s2.0-0026541587 01/01/1992 5 Citations

The radiation dose-response relationship in a human glioma xenograft and an evaluation of the influence of glutathione depletion by buthionine sulfoximine. (Halperin EC, Brizel DM, Honore G, Sontag MR, Griffith OW, Bigner DD, Friedman HS) Int J Radiat Oncol Biol Phys 1992;24(1):103-9 PMID: 1512145 SCOPUS ID: 2-s2.0-0026746375 01/01/1992 9 Citations

Mammalian nitric oxide synthases. (Stuehr DJ, Griffith OW) Adv Enzymol Relat Areas Mol Biol 1992;65:287-346 PMID: 1373932 SCOPUS ID: 2-s2.0-0026456161 01/01/1992 612 Citations

Effect of carnitine acetyltransferase inhibition on rat hepatocyte metabolism. (Brass EP, Gandour RD, Griffith OW) Biochim Biophys Acta 1991 Oct 16;1095(1):17-22 PMID: 1932127 SCOPUS ID: 2-s2.0-0025998978 10/16/1991 7 Citations

L-carnitine protection in ammonia intoxication. Effect of aminocarnitine on carnitine-dependent metabolism and acute ammonia toxicity. (Ohtsuka Y, Griffith OW) Biochem Pharmacol 1991 Jun 15;41(12):1957-61 PMID: 2039546 SCOPUS ID: 2-s2.0-0025868758 06/15/1991 14 Citations

Analytical and preparative separation of the diastereomers of L-buthionine (SR)-sulfoximine, a potent inhibitor of glutathione biosynthesis. (Campbell EB, Hayward ML, Griffith OW) Anal Biochem 1991 May 01;194(2):268-77 PMID: 1677799 SCOPUS ID: 2-s2.0-0025758343 05/01/1991 51 Citations

N omega-hydroxy-L-arginine is an intermediate in the biosynthesis of nitric oxide from L-arginine. (Stuehr DJ, Kwon NS, Nathan CF, Griffith OW, Feldman PL, Wiseman J) J Biol Chem 1991 Apr 05;266(10):6259-63 PMID: 1706713 SCOPUS ID: 2-s2.0-0025892441 04/05/1991 532 Citations

2,3,7,8-Tetrachlorodibenzo-p-dioxin increases reliance on fats as a fuel source independently of diet: evidence that diminished carbohydrate supply contributes to dioxin lethality. (Lentnek M, Griffith OW, Rifkind AB) Biochem Biophys Res Commun 1991 Feb 14;174(3):1267-71 PMID: 1996990 SCOPUS ID: 2-s2.0-0025963482 02/14/1991 15 Citations

Melphalan-induced toxicity in nude mice following pretreatment with buthionine sulfoximine. (Skapek SX, VanDellen AF, McMahon DP, Postels DG, Griffith OW, Bigner DD, Friedman HS) Cancer Chemother Pharmacol 1991;28(1):15-21 PMID: 2040029 SCOPUS ID: 2-s2.0-0025860410 01/01/1991 12 Citations

L-arginine, but not N alpha-benzoyl-L-arginine ethyl ester, is a precursor of endothelium-derived relaxing factor. (Fasehun OA, Gross SS, Rubin LE, Jaffe EA, Griffith OW, Levi R) J Pharmacol Exp Ther 1990 Dec;255(3):1348-53 PMID: 2175803 SCOPUS ID: 2-s2.0-0025600354 12/01/1990 7 Citations

Reversal of endotoxin-mediated shock by NG-methyl-L-arginine, an inhibitor of nitric oxide synthesis. (Kilbourn RG, Jubran A, Gross SS, Griffith OW, Levi R, Adams J, Lodato RF) Biochem Biophys Res Commun 1990 Nov 15;172(3):1132-8 PMID: 2244897 SCOPUS ID: 2-s2.0-0025242299 11/15/1990 586 Citations

L-citrulline production from L-arginine by macrophage nitric oxide synthase. The ureido oxygen derives from dioxygen. (Kwon NS, Nathan CF, Gilker C, Griffith OW, Matthews DE, Stuehr DJ) J Biol Chem 1990 Aug 15;265(23):13442-5 PMID: 1696255 SCOPUS ID: 2-s2.0-0025143221 08/15/1990 242 Citations

Macrophage and endothelial cell nitric oxide synthesis: cell-type selective inhibition by NG-aminoarginine, NG-nitroarginine and NG-methylarginine. (Gross SS, Stuehr DJ, Aisaka K, Jaffe EA, Levi R, Griffith OW) Biochem Biophys Res Commun 1990 Jul 16;170(1):96-103 PMID: 2372300 SCOPUS ID: 2-s2.0-0025046968 07/16/1990 280 Citations

NG-methyl-L-arginine inhibits tumor necrosis factor-induced hypotension: implications for the involvement of nitric oxide. (Kilbourn RG, Gross SS, Jubran A, Adams J, Griffith OW, Levi R, Lodato RF) Proc Natl Acad Sci U S A 1990 May;87(9):3629-32 PMID: 2333306 PMCID: PMC53955 SCOPUS ID: 2-s2.0-0025195627 05/01/1990 651 Citations

Rate of buthionine sulfoximine entry into brain and xenotransplanted human gliomas. (Fekete I, Griffith OW, Schlageter KE, Bigner DD, Friedman HS, Groothuis DR) Cancer Res 1990 Feb 15;50(4):1251-6 PMID: 2297773 SCOPUS ID: 2-s2.0-0025139681 02/15/1990 20 Citations

L-buthionine-sulfoximine-mediated radiosensitization in experimental interstitial radiotherapy of intracerebral D-54 MG glioma xenografts in athymic mice. (Lippitz BE, Halperin EC, Griffith OW, Colvin OM, Honore G, Ostertag CB, Bigner DD, Friedman HS) Neurosurgery 1990 Feb;26(2):255-60 PMID: 2308673 SCOPUS ID: 2-s2.0-0025305153 02/01/1990 17 Citations

Lack of effect of glutathione depletion by L-buthionine-S,R-sulfoximine on gentamicin nephrotoxicity in rats. (Wu DF, Griffith OW, Reidenberg MM) Pharmacology 1990;40(5):250-7 PMID: 2274571 SCOPUS ID: 2-s2.0-0025045993 01/01/1990 8 Citations

Metabolic effects of carnitine and carnitine analogs. (Ohtsuka Y, Clark DJ, Griffith OW) Adv Exp Med Biol 1990;272:159-74 PMID: 2103684 SCOPUS ID: 2-s2.0-0025552148 01/01/1990

Establishment of a melphalan-resistant rhabdomyosarcoma xenograft with cross-resistance to vincristine and enhanced sensitivity following buthionine sulfoximine-mediated glutathione depletion. (Rosenberg MC, Colvin OM, Griffith OW, Bigner SH, Elion GB, Horton JK, Lilley E, Bigner DD, Friedman HS) Cancer Res 1989 Dec 15;49(24 Pt 1):6917-22 PMID: 2582434 SCOPUS ID: 2-s2.0-0024817998 12/15/1989 29 Citations

Glutathione monoethyl ester: high-performance liquid chromatographic analysis and direct preparation of the free base form. (Campbell EB, Griffith OW) Anal Biochem 1989 Nov 15;183(1):21-5 PMID: 2619045 SCOPUS ID: 2-s2.0-0024332108 11/15/1989 19 Citations

Effect of orally administered L-carnitine on blood ammonia and L-carnitine concentrations in portacaval-shunted rats. (Hearn TJ, Coleman AE, Lai JC, Griffith OW, Cooper AJ) Hepatology 1989 Nov;10(5):822-8 PMID: 2807161 SCOPUS ID: 2-s2.0-0024453030 11/01/1989 26 Citations

L-arginine availability determines the duration of acetylcholine-induced systemic vasodilation in vivo. (Aisaka K, Gross SS, Griffith OW, Levi R) Biochem Biophys Res Commun 1989 Sep 15;163(2):710-7 PMID: 2783117 SCOPUS ID: 2-s2.0-0024440973 09/15/1989 126 Citations

NG-methylarginine, an inhibitor of endothelium-derived nitric oxide synthesis, is a potent pressor agent in the guinea pig: does nitric oxide regulate blood pressure in vivo? (Aisaka K, Gross SS, Griffith OW, Levi R) Biochem Biophys Res Commun 1989 Apr 28;160(2):881-6 PMID: 2719705 SCOPUS ID: 2-s2.0-0024475102 04/28/1989 421 Citations

Increased melphalan activity in intracranial human medulloblastoma and glioma xenografts following buthionine sulfoximine-mediated glutathione depletion. (Friedman HS, Colvin OM, Griffith OW, Lippitz B, Elion GB, Schold SC Jr, Hilton J, Bigner DD) J Natl Cancer Inst 1989 Apr 05;81(7):524-7 PMID: 2921776 SCOPUS ID: 2-s2.0-0024522118 04/05/1989 35 Citations

Buthionine sulfoximine-mediated depletion of glutathione in intracranial human glioma-derived xenografts. (Skapek SX, Colvin OM, Griffith OW, Groothuis DR, Colapinto EV, Lee Y, Hilton J, Elion GB, Bigner DD, Friedman HS) Biochem Pharmacol 1988 Nov 15;37(22):4313-7 PMID: 3196356 SCOPUS ID: 2-s2.0-0023727621 11/15/1988 20 Citations

In vivo studies of cysteine metabolism. Use of D-cysteinesulfinate, a novel cysteinesulfinate decarboxylase inhibitor, to probe taurine and pyruvate synthesis. (Weinstein CL, Haschemeyer RH, Griffith OW) J Biol Chem 1988 Nov 15;263(32):16568-79 PMID: 3182803 SCOPUS ID: 2-s2.0-0023796961 11/15/1988 32 Citations

An elective course for first-year students based on the New England Journal of Medicine. (Griffith OW, Goss ME, Tardiff K, Cassell EJ, Pardee JD, Weinstein AM) J Med Educ 1988 Jul;63(7):559-61 PMID: 3385755 SCOPUS ID: 2-s2.0-0024044224 07/01/1988 1 Citation

Enhanced melphalan cytotoxicity following buthionine sulfoximine-mediated glutathione depletion in a human medulloblastoma xenograft in athymic mice. (Skapek SX, Colvin OM, Griffith OW, Elion GB, Bigner DD, Friedman HS) Cancer Res 1988 May 15;48(10):2764-7 PMID: 3359437 SCOPUS ID: 2-s2.0-0023927105 05/15/1988 57 Citations

Cysteinesulfonate and beta-sulfopyruvate metabolism. Partitioning between decarboxylation, transamination, and reduction pathways. (Weinstein CL, Griffith OW) J Biol Chem 1988 Mar 15;263(8):3735-43 PMID: 3346220 SCOPUS ID: 2-s2.0-0023841769 03/15/1988 19 Citations

Multiple forms of rat liver cysteinesulfinate decarboxylase. (Weinstein CL, Griffith OW) J Biol Chem 1987 May 25;262(15):7254-63 PMID: 3584115 SCOPUS ID: 2-s2.0-0023664489 05/25/1987 25 Citations

Cysteinesulfinate decarboxylase. (Weinstein CL, Griffith OW) Methods Enzymol 1987;143:404-10 PMID: 3309560 SCOPUS ID: 2-s2.0-0023610754 01/01/1987 2 Citations

Mammalian sulfur amino acid metabolism: an overview. (Griffith OW) Methods Enzymol 1987;143:366-76 PMID: 3309559 SCOPUS ID: 2-s2.0-0023068040 01/01/1987 252 Citations

Sulfinic acids from disulfides: L-[35S]cysteinesulfinic acid. (Griffith OW, Weinstein CL) Methods Enzymol 1987;143:270-4 PMID: 3309556 SCOPUS ID: 2-s2.0-0023078768 01/01/1987 8 Citations

Amino acid sulfoximines: alpha-ethylmethionine sulfoximine. (Griffith OW) Methods Enzymol 1987;143:286-91 PMID: 3657547 SCOPUS ID: 2-s2.0-0023083559 01/01/1987 1 Citation

Sulfonic acids: L-homocysteinesulfonic acid. (Hayward MA, Campbell EB, Griffith OW) Methods Enzymol 1987;143:279-81 PMID: 3657545 SCOPUS ID: 2-s2.0-0023084125 01/01/1987 7 Citations

Amino acid sulfones: S-benzyl-DL-alpha-methylcysteine sulfone. (Griffith OW) Methods Enzymol 1987;143:274-9 PMID: 3657544 SCOPUS ID: 2-s2.0-0023064118 01/01/1987 2 Citations

beta-Sulfopyruvate. (Griffith OW, Weinstein CL) Methods Enzymol 1987;143:221-3 PMID: 3657538 SCOPUS ID: 2-s2.0-0023085832 01/01/1987 11 Citations

Resolution of cysteine and methionine enantiomers. (Griffith OW, Campbell EB) Methods Enzymol 1987;143:166-72 PMID: 3657532 SCOPUS ID: 2-s2.0-0023085831 01/01/1987 5 Citations

Gamma-glutamyl-glutathione. Natural occurrence and enzymology. (Abbott WA, Griffith OW, Meister A) J Biol Chem 1986 Oct 15;261(29):13657-61 PMID: 2875999 SCOPUS ID: 2-s2.0-0023032786 10/15/1986 22 Citations

Liquid chromatographic separation of enantiomers of beta-amino acids using a chiral stationary phase. (Griffith OW, Campbell EB, Pirkle WH, Tsipouras A, Hyun MH) J Chromatogr 1986 Jul 25;362(3):345-52 PMID: 3760049 SCOPUS ID: 2-s2.0-0023056823 07/25/1986 24 Citations

beta-Sulfopyruvate: chemical and enzymatic syntheses and enzymatic assay. (Weinstein CL, Griffith OW) Anal Biochem 1986 Jul;156(1):154-60 PMID: 3740406 SCOPUS ID: 2-s2.0-0022504969 07/01/1986 8 Citations

Beta-amino acids: mammalian metabolism and utility as alpha-amino acid analogues. (Griffith OW) Annu Rev Biochem 1986;55:855-78 PMID: 3090932 SCOPUS ID: 2-s2.0-0022555878 01/01/1986 176 Citations

Antiketogenic and hypoglycemic effects of aminocarnitine and acylaminocarnitines. (Jenkins DL, Griffith OW) Proc Natl Acad Sci U S A 1986 Jan;83(2):290-4 PMID: 3455765 PMCID: PMC322843 SCOPUS ID: 2-s2.0-0009526722 01/01/1986 46 Citations

DL-aminocarnitine and acetyl-DL-aminocarnitine. Potent inhibitors of carnitine acyltransferases and hepatic triglyceride catabolism. (Jenkins DL, Griffith OW) J Biol Chem 1985 Nov 25;260(27):14748-55 PMID: 3840486 SCOPUS ID: 2-s2.0-0022345034 11/25/1985 47 Citations

Origin and turnover of mitochondrial glutathione. (Griffith OW, Meister A) Proc Natl Acad Sci U S A 1985 Jul;82(14):4668-72 PMID: 3860816 PMCID: PMC390447 SCOPUS ID: 2-s2.0-0001547757 07/01/1985 484 Citations

5-Oxo-L-prolinase from rat kidney. (Meister A, Griffith OW, Williamson JM) Methods Enzymol 1985;113:445-51 PMID: 3911006 SCOPUS ID: 2-s2.0-0022272474 01/01/1985 11 Citations

Formation of respiratory 14CO2 from radiolabeled substrates. (Griffith OW) Methods Enzymol 1985;113:461-8 PMID: 3937018 SCOPUS ID: 2-s2.0-0022272477 01/01/1985

Cysteinesulfinate metabolism. altered partitioning between transamination and decarboxylation following administration of beta-methyleneaspartate. (Griffith OW) J Biol Chem 1983 Feb 10;258(3):1591-8 PMID: 6822523 SCOPUS ID: 2-s2.0-0020535455 02/10/1983 92 Citations

Mechanism of action, metabolism, and toxicity of buthionine sulfoximine and its higher homologs, potent inhibitors of glutathione synthesis. (Griffith OW) J Biol Chem 1982 Nov 25;257(22):13704-12 PMID: 6128339 SCOPUS ID: 2-s2.0-0020444895 11/25/1982 673 Citations

Interaction of 5-oxo-L-prolinase with nucleoside triphosphates. Evidence suggesting substrate-dependent conformational change. (Griffith OW, Meister A) J Biol Chem 1982 Apr 25;257(8):4392-7 PMID: 6121802 SCOPUS ID: 2-s2.0-0020490543 04/25/1982 4 Citations

Arachidonic acid metabolism in glutathione-deficient macrophages. (Rouzer CA, Scott WA, Griffith OW, Hamill AL, Cohn ZA) Proc Natl Acad Sci U S A 1982 Mar;79(5):1621-5 PMID: 6803245 PMCID: PMC346027 SCOPUS ID: 2-s2.0-0020064271 03/01/1982 52 Citations

Glutathione metabolism in resting and phagocytizing peritoneal macrophages. (Rouzer CA, Scott WA, Griffith OW, Hamill AL, Cohn ZA) J Biol Chem 1982 Feb 25;257(4):2002-8 PMID: 6120172 SCOPUS ID: 2-s2.0-0020056643 02/25/1982 72 Citations

Glutathione depletion sensitizes tumor cells to oxidative cytolysis. (Arrick BA, Nathan CF, Griffith OW, Cohn ZA) J Biol Chem 1982 Feb 10;257(3):1231-7 PMID: 6799503 SCOPUS ID: 2-s2.0-0020055988 02/10/1982 189 Citations

The role of glutathione turnover in the apparent renal secretion of cystine. (Griffith OW) J Biol Chem 1981 Dec 10;256(23):12263-8 PMID: 6795199 SCOPUS ID: 2-s2.0-0019803089 12/10/1981 32 Citations

5-Oxo-L-prolinase (L-pyroglutamate hydrolase). Studies of the chemical mechanism. (Griffith OW, Meister A) J Biol Chem 1981 Oct 10;256(19):9981-5 PMID: 6115861 SCOPUS ID: 2-s2.0-0019877429 10/10/1981 15 Citations

Glutathione turnover in human erythrocytes. Inhibition by buthionine sulfoximine and incorporation of glycine by exchange. (Griffith OW) J Biol Chem 1981 May 25;256(10):4900-4 PMID: 6112221 SCOPUS ID: 2-s2.0-0019798176 05/25/1981 64 Citations

Formation of gamma-glutamycyst(e)ine in vivo is catalyzed by gamma-glutamyl transpeptidase. (Griffith OW, Bridges RJ, Meister A) Proc Natl Acad Sci U S A 1981 May;78(5):2777-81 PMID: 6114489 PMCID: PMC319440 SCOPUS ID: 2-s2.0-0019570008 05/01/1981 34 Citations

Depletion of glutathione selectively inhibits synthesis of leukotriene C by macrophages. (Rouzer CA, Scott WA, Griffith OW, Hamill AL, Cohn ZA) Proc Natl Acad Sci U S A 1981 Apr;78(4):2532-6 PMID: 6113592 PMCID: PMC319382 SCOPUS ID: 2-s2.0-0019415078 04/01/1981 50 Citations

Chemical ionization mass spectra of L-methionine and L-methionine analogs. (Cooper AJ, Griffith OW, Meister A, Field FH) Biomed Mass Spectrom 1981 Mar;8(3):95-8 PMID: 6786387 SCOPUS ID: 2-s2.0-0019547987 03/01/1981 2 Citations

Inhibition of glutathione synthesis as a chemotherapeutic strategy for trypanosomiasis. (Arrick BA, Griffith OW, Cerami A) J Exp Med 1981 Mar 01;153(3):720-5 PMID: 7252412 PMCID: PMC2186096 SCOPUS ID: 2-s2.0-0019512549 03/01/1981 127 Citations

Depletion of glutathione by inhibition of biosynthesis. (Griffith OW) Methods Enzymol 1981;77:59-63 PMID: 6120437 SCOPUS ID: 2-s2.0-0019765119 01/01/1981 96 Citations

Gamma-glutamyl transpeptidase. (Meister A, Tate SS, Griffith OW) Methods Enzymol 1981;77:237-53 PMID: 6120436 SCOPUS ID: 2-s2.0-0019740858 01/01/1981 381 Citations

Interaction of L- and D-3-amino-1-chloro-2-pentanone with gamma-glutamylcysteine synthetase. (Beamer RL, Griffith OW, Gass JD, Anderson ME, Meister A) J Biol Chem 1980 Dec 25;255(24):11732-6 PMID: 6108326 SCOPUS ID: 2-s2.0-0019333280 12/25/1980 16 Citations

L-gamma-(Threo-beta-methyl)glutamyl-L-alpha-aminobutyrate, a selective substrate of alpha-glutamyl cyclotransferase. (Bridges RJ, Griffith OW, Meister A) J Biol Chem 1980 Nov 25;255(22):10787-92 PMID: 6107299 SCOPUS ID: 2-s2.0-0019333231 11/25/1980 14 Citations

Determination of glutathione and glutathione disulfide using glutathione reductase and 2-vinylpyridine. (Griffith OW) Anal Biochem 1980 Jul 15;106(1):207-12 PMID: 7416462 SCOPUS ID: 2-s2.0-0019167355 07/15/1980 4493 Citations

The apparent glutathione oxidase activity of gamma-glutamyl transpeptidase. Chemical mechanism. (Griffith OW, Tate SS) J Biol Chem 1980 Jun 10;255(11):5011-4 PMID: 6102993 SCOPUS ID: 2-s2.0-0019321209 06/10/1980 74 Citations

Excretion of cysteine and gamma-glutamylcysteine moieties in human and experimental animal gamma-glutamyl transpeptidase deficiency. (Griffith OW, Meister A) Proc Natl Acad Sci U S A 1980 Jun;77(6):3384-7 PMID: 6106190 PMCID: PMC349620 SCOPUS ID: 2-s2.0-0019023638 06/01/1980 113 Citations

Transport of gamma-glutamyl amino acids: role of glutathione and gamma-glutamyl transpeptidase. (Griffith OW, Bridges RJ, Meister A) Proc Natl Acad Sci U S A 1979 Dec;76(12):6319-22 PMID: 42913 PMCID: PMC411855 SCOPUS ID: 2-s2.0-0018594336 12/01/1979 148 Citations

Glutathione: interorgan translocation, turnover, and metabolism. (Griffith OW, Meister A) Proc Natl Acad Sci U S A 1979 Nov;76(11):5606-10 PMID: 42902 PMCID: PMC411698 SCOPUS ID: 2-s2.0-0345654274 11/01/1979 586 Citations

Potent and specific inhibition of glutathione synthesis by buthionine sulfoximine (S-n-butyl homocysteine sulfoximine). (Griffith OW, Meister A) J Biol Chem 1979 Aug 25;254(16):7558-60 PMID: 38242 SCOPUS ID: 2-s2.0-0018666729 08/25/1979 1535 Citations

Glutathione synthetase. Purification from rat kidney and mapping of the substrate binding sites. (Oppenheimer L, Wellner VP, Griffith OW, Meister A) J Biol Chem 1979 Jun 25;254(12):5184-90 PMID: 447639 SCOPUS ID: 2-s2.0-0018801016 06/25/1979 108 Citations

Effects of methionine sulfoximine analogs on the synthesis of glutamine and glutathione: possible chemotherapeutic implications. (Meister A, Griffith OW) Cancer Treat Rep 1979 Jun;63(6):1115-21 PMID: 38004 SCOPUS ID: 2-s2.0-0018662788 06/01/1979 72 Citations

Translocation of glutathione from lymphoid cells that have markedly different gamma-glutamyl transpeptidase activities. (Griffith OW, Novogrodsky A, Meister A) Proc Natl Acad Sci U S A 1979 May;76(5):2249-52 PMID: 36614 PMCID: PMC383576 SCOPUS ID: 2-s2.0-0018390451 05/01/1979 50 Citations

N-hydroxyamino acids. Irreversible inhibitors of pyridoxal 5'-phosphate enzymes and substrates of D- and L-amino acid oxidases. (Cooper AJ, Griffith OW) J Biol Chem 1979 Apr 25;254(8):2748-53 PMID: 34607 SCOPUS ID: 2-s2.0-0018389209 04/25/1979 25 Citations

Inhibition of glutathione biosynthesis by prothionine sulfoximine (S-n-propyl homocysteine sulfoximine), a selective inhibitor of gamma-glutamylcysteine synthetase. (Griffith OW, Anderson ME, Meister A) J Biol Chem 1979 Feb 25;254(4):1205-10 PMID: 33187 SCOPUS ID: 2-s2.0-0018800337 02/25/1979 142 Citations

New aspects of glutathione metabolism and translocation in mammals. (Meister A, Griffith OW, Novogrodsky A, Tate SS) Ciba Found Symp 1979(72):135-61 PMID: 45011 SCOPUS ID: 2-s2.0-0018561333 01/01/1979 41 Citations

Translocation of intracellular glutathione to membrane-bound gamma-glutamyl transpeptidase as a discrete step in the gamma-glutamyl cycle: glutathionuria after inhibition of transpeptidase. (Griffith OW, Meister A) Proc Natl Acad Sci U S A 1979 Jan;76(1):268-72 PMID: 34150 PMCID: PMC382920 SCOPUS ID: 2-s2.0-0012971643 01/01/1979 224 Citations

Evidence that the gamma-glutamyl cycle functions in vivo using intracellular glutathione: effects of amino acids and selective inhibition of enzymes. (Griffith OW, Bridges RJ, Meister A) Proc Natl Acad Sci U S A 1978 Nov;75(11):5405-8 PMID: 31622 PMCID: PMC392972 SCOPUS ID: 2-s2.0-0018168953 11/01/1978 112 Citations

Differential inhibition of glutamine and gamma-glutamylcysteine synthetases by alpha-alkyl analogs of methionine sulfoximine that induce convulsions. (Griffith OW, Meister A) J Biol Chem 1978 Apr 10;253(7):2333-8 PMID: 24637 SCOPUS ID: 2-s2.0-0017804058 04/10/1978 84 Citations

Inhibition of gamma-glutamylcysteine synthetase by cystamine: an approach to a therapy of 5-oxoprolinuria (pyroglutamic aciduria). (Griffith OW, Larsson A, Meister A) Biochem Biophys Res Commun 1977 Dec 07;79(3):919-25 PMID: 23121 SCOPUS ID: 2-s2.0-0017652199 12/07/1977 68 Citations

Selective inhibition of gamma-glutamyl-cycle enzymes by substrate analogs. (Griffith OW, Meister A) Proc Natl Acad Sci U S A 1977 Aug;74(8):3330-4 PMID: 20626 PMCID: PMC431550 SCOPUS ID: 2-s2.0-0012924310 08/01/1977 32 Citations

Inhibition of carbamyl phosphate synthetase by P1, P5-di(adenosine 5')-pentaphosphate: evidence for two ATP binding sites. (Powers SG, Griffith OW, Meister A) J Biol Chem 1977 May 25;252(10):3558-60 PMID: 193838 SCOPUS ID: 2-s2.0-0017404154 05/25/1977 37 Citations

Dependence of energy coupling on nucleotide base structure in the reaction catalyzed by 5-oxo-L-prolinase. (Griffith OW, Meister A) Biochem Biophys Res Commun 1976 Jun 07;70(3):759-65 PMID: 938527 SCOPUS ID: 2-s2.0-0017074202 06/07/1976 4 Citations

5-Oxo-L-prolinase (L-pyroglutamate hydrolase). Purification and catalytic properties. (Van Der Werf P, Griffith OW, Meister A) J Biol Chem 1975 Sep 10;250(17):6686-92 PMID: 239948 SCOPUS ID: 2-s2.0-0016710798 09/10/1975 47 Citations

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Owen Griffith PhD

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Publications (139)