Medical College of Wisconsin
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Pui Kei Wu PhD

Pui Kei Wu PhD profile photo picture

Instructor

Institution: Medical College of Wisconsin
Department: Biochemistry

Member of the Cancer Center


I am willing to collaborate on research projects.


Research Experience

  • Apoptosis
  • Cell Cycle
  • Cell Differentiation
  • Cell Survival
  • Drug Resistance, Neoplasm
  • HSP70 Heat-Shock Proteins
  • MAP Kinase Signaling System
  • Mitochondria
  • Phosphorylation
  • Protein Kinase Inhibitors
  • Proto-Oncogene Proteins B-raf
  • Clinical Expertise

  • Mice
  • Xenograft Model Antitumor Assays
  • Methodologies and Techniques

  • Apoptosis
  • Cell Cycle
  • Drug Resistance, Neoplasm
  • Mitochondria
  • Phosphorylation
  • Publications (19)

  • Growth Inhibitory Signaling of the Raf/MEK/ERK Pathway. (Wu PK, Becker A, Park JI) Int J Mol Sci 2020 Jul 30;21(15) PMID: 32751750 PMCID: PMC7432891 SCOPUS ID: 2-s2.0-85089131301 08/06/2020    
  • Mortalin/HSPA9 targeting selectively induces KRAS tumor cell death by perturbing mitochondrial membrane permeability. (Wu PK, Hong SK, Starenki D, Oshima K, Shao H, Gestwicki JE, Tsai S, Park JI) Oncogene 2020 05;39(21):4257-4270 PMID: 32291414 PMCID: PMC7244387 SCOPUS ID: 2-s2.0-85083767959 04/16/2020       1 Citation
  • Mortalin (HSPA9) facilitates BRAF-mutant tumor cell survival by suppressing ANT3-mediated mitochondrial membrane permeability. (Wu PK, Hong SK, Chen W, Becker AE, Gundry RL, Lin CW, Shao H, Gestwicki JE, Park JI) Sci Signal 2020 Mar 10;13(622) PMID: 32156782 PMCID: PMC7099430 SCOPUS ID: 2-s2.0-85081677231 03/12/2020       2 Citations
  • Treatment of Cells and Tissues with Chromate Maximizes Mitochondrial 2Fe2S EPR Signals. (Antholine WE, Vasquez-Vivar J, Quirk BJ, Whelan HT, Wu PK, Park JI, Myers CR) Int J Mol Sci 2019 Mar 06;20(5) PMID: 30845710 PMCID: PMC6429069 SCOPUS ID: 2-s2.0-85062628835 03/09/2019       1 Citation
  • A cellular threshold for active ERK1/2 levels determines Raf/MEK/ERK-mediated growth arrest versus death responses. (Hong SK, Wu PK, Park JI) Cell Signal 2018 Jan;42:11-20 PMID: 28986121 PMCID: PMC5732048 SCOPUS ID: 2-s2.0-85031106212 10/08/2017       5 Citations
  • Steady-State Levels of Phosphorylated Mitogen-Activated Protein Kinase Kinase 1/2 Determined by Mortalin/HSPA9 and Protein Phosphatase 1 Alpha in KRAS and BRAF Tumor Cells. (Wu PK, Hong SK, Park JI) Mol Cell Biol 2017 Sep 15;37(18) PMID: 28674184 PMCID: PMC5574043 SCOPUS ID: 2-s2.0-85028363255 07/05/2017       8 Citations
  • Vandetanib and cabozantinib potentiate mitochondria-targeted agents to suppress medullary thyroid carcinoma cells. (Starenki D, Hong SK, Wu PK, Park JI) Cancer Biol Ther 2017 Jul 03;18(7):473-483 PMID: 28475408 PMCID: PMC5639831 SCOPUS ID: 2-s2.0-85020693671 05/06/2017       10 Citations
  • Suppression of B-RafV600E melanoma cell survival by targeting mitochondria using triphenyl-phosphonium-conjugated nitroxide or ubiquinone. (Hong SK, Starenki D, Wu PK, Park JI) Cancer Biol Ther 2017 02;18(2):106-114 PMID: 27786591 PMCID: PMC5362989 SCOPUS ID: 2-s2.0-85013783900 10/28/2016       12 Citations
  • MEK1/2 Inhibitors: Molecular Activity and Resistance Mechanisms. (Wu PK, Park JI) Semin Oncol 2015 Dec;42(6):849-62 PMID: 26615130 PMCID: PMC4663016 SCOPUS ID: 2-s2.0-84962305085 11/29/2015       32 Citations
  • ERK1/2 can feedback-regulate cellular MEK1/2 levels. (Hong SK, Wu PK, Karkhanis M, Park JI) Cell Signal 2015 Oct;27(10):1939-48 PMID: 26163823 PMCID: PMC4540659 SCOPUS ID: 2-s2.0-84936994796 07/15/2015       13 Citations
  • Active ERK2 is sufficient to mediate growth arrest and differentiation signaling. (Wu PK, Hong SK, Yoon SH, Park JI) FEBS J 2015 Mar;282(6):1017-30 PMID: 25639353 PMCID: PMC4368470 SCOPUS ID: 2-s2.0-84925621653 02/03/2015       12 Citations
  • Raf/MEK/ERK can regulate cellular levels of LC3B and SQSTM1/p62 at expression levels. (Kim JH, Hong SK, Wu PK, Richards AL, Jackson WT, Park JI) Exp Cell Res 2014 Oct 01;327(2):340-52 PMID: 25128814 PMCID: PMC4164593 SCOPUS ID: 2-s2.0-84907665306 08/17/2014       54 Citations
  • A mortalin/HSPA9-mediated switch in tumor-suppressive signaling of Raf/MEK/extracellular signal-regulated kinase. (Wu PK, Hong SK, Veeranki S, Karkhanis M, Starenki D, Plaza JA, Park JI) Mol Cell Biol 2013 Oct;33(20):4051-67 PMID: 23959801 PMCID: PMC3811686 SCOPUS ID: 2-s2.0-84886885205 08/21/2013       38 Citations
  • The Predicted Proteomic Network Associated with the Antiarthritic Action of Qingfu Guanjieshu in Collagen-II-Induced Arthritis in Rats. (Wang TY, Zhou H, Wong YF, Wu PK, Hsiao WL, Leung EL, Liu L) Evid Based Complement Alternat Med 2013;2013:582493 PMID: 23781264 PMCID: PMC3678439 06/20/2013    
  • Chemical and DNA authentication of taste variants of Gynostemma pentaphyllum herbal tea. (Wu PK, Tai WC, Choi RC, Tsim KW, Zhou H, Liu X, Jiang ZH, Hsiao WL) Food Chem 2011 Sep 01;128(1):70-80 PMID: 25214331 09/01/2011    
  • Oleanolic acid isolated from Oldenlandia diffusa exhibits a unique growth inhibitory effect against ras-transformed fibroblasts. (Wu PK, Chi Shing Tai W, Liang ZT, Zhao ZZ, Hsiao WL) Life Sci 2009 Jul 17;85(3-4):113-21 PMID: 19433096 SCOPUS ID: 2-s2.0-67449138570 05/13/2009       28 Citations
  • Anticancer activities and the drug targets of botanical saponins from a medicinal herb, gynostemma pentaphyllum (Hsiao WLW, Tai WCS, Mo Z, Wu PK) Journal of Acupuncture and Tuina Science October 2008;6(5):271-272 SCOPUS ID: 2-s2.0-55649107983 10/01/2008    
  • The angiosuppressive effects of 20(R)- ginsenoside Rg3. (Yue PY, Wong DY, Wu PK, Leung PY, Mak NK, Yeung HW, Liu L, Cai Z, Jiang ZH, Fan TP, Wong RN) Biochem Pharmacol 2006 Aug 14;72(4):437-45 PMID: 16793023 SCOPUS ID: 2-s2.0-33745938530 06/24/2006       169 Citations
  • Involvement of protein kinase C and E2F-5 in euxanthone-induced neurite differentiation of neuroblastoma. (Ha WY, Wu PK, Kok TW, Leung KW, Mak NK, Yue PY, Ngai SM, Tsai SN, Wong RN) Int J Biochem Cell Biol 2006;38(8):1393-401 PMID: 16546434 SCOPUS ID: 2-s2.0-33646192904 03/21/2006       17 Citations
  • Last update: 10/28/2020
    jenkins-FCD Prod-484 8aa07fc50b7f6d102f3dda2f4c7056ff84294d1d