Medical College of Wisconsin
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Robert Keyes

Research Scientist II

Institution: Medical College of Wisconsin
Department: Biochemistry

Publications (25)

  • Mitochondria-targeted metformin analogs activate the ER stress-unfolded protein response pathway to drive apoptosis in pancreatic cancer. (Poimenidou M, Bobek JM, Drouillard D, Harris T, Solis E, Darnell C, McAllister D, Keyes RF, Ishihara-Aoki M, Aoki K, Sahoo D, Kalyanaraman B, Smith BC, Dwinell MB) Cell Death Dis 2026 May 22;17(1) PMID: 42173830 PMCID: PMC13372815 SCOPUS ID: 2-s2.0-105044729704 05/23/2026    
  • Polybromo‑1 Bromodomain Inhibitor Selectivity Is Mediated by a Unique Ligand-Binding Pocket. (Nuñez R, Bursch KL, Makowski SJ, Xue M, Cozzolino KA, Shishodia S, Keyes RF, Zhu N, Smith BC) ACS Med Chem Lett 2025 Oct 09;16(10):1955-1962 PMID: 41089488 PMCID: PMC12516376 SCOPUS ID: 2-s2.0-105018704767 10/15/2025    
  • Reutericyclin, a specialized metabolite of Limosilactobacillus reuteri, mitigates risperidone-induced weight gain in mice. (Aboulalazm FA, Kazen AB, deLeon O, Müller S, Saravia FL, Lozada-Fernandez V, Hadiono MA, Keyes RF, Smith BC, Kellogg SL, Grobe JL, Kindel TL, Kirby JR) Gut Microbes 2025 Dec;17(1):2477819 PMID: 40190120 PMCID: PMC11980487 SCOPUS ID: 2-s2.0-105002217346 04/07/2025       4 Citations
  • The TRIM33 Bromodomain Recognizes Histone Lysine Lactylation. (Nuñez R, Sidlowski PFW, Steen EA, Wynia-Smith SL, Sprague DJ, Keyes RF, Smith BC) ACS Chem Biol 2024 Dec 20;19(12):2418-2428 PMID: 39556662 PMCID: PMC11706526 SCOPUS ID: 2-s2.0-85209707761 11/18/2024       65 Citations
  • Lipid Trolling to Optimize A3 Adenosine Receptor-Positive Allosteric Modulators (PAMs). (Pradhan B, Pavan M, Fisher CL, Salmaso V, Wan TC, Keyes RF, Rollison N, Suresh RR, Kumar TS, Gao ZG, Smith BC, Auchampach JA, Jacobson KA) J Med Chem 2024 Jul 25;67(14):12221-12247 PMID: 38959401 PMCID: PMC11636968 SCOPUS ID: 2-s2.0-85197620924 07/03/2024       7 Citations
  • Extrahelical Binding Site for a 1H-Imidazo[4,5-c]quinolin-4-amine A3 Adenosine Receptor Positive Allosteric Modulator on Helix 8 and Distal Portions of Transmembrane Domains 1 and 7. (Fisher CL, Pavan M, Salmaso V, Keyes RF, Wan TC, Pradhan B, Gao ZG, Smith BC, Jacobson KA, Auchampach JA) Mol Pharmacol 2024 Feb 15;105(3):213-223 PMID: 38182432 PMCID: PMC10877738 SCOPUS ID: 2-s2.0-85185222449 01/06/2024       9 Citations
  • Synthesis of fluorinated triphenylphosphonium analogs that improve cancer cell selectivity and in vivo detection. (Keyes RF, McAllister D, Dwinell MB, Smith BC) STAR Protoc 2023 Sep 15;4(3):102437 PMID: 37552599 PMCID: PMC10424135 SCOPUS ID: 2-s2.0-85175638505 08/08/2023       1 Citation
  • Sulfenylation links oxidative stress to protein disulfide isomerase oxidase activity and thrombus formation. (Yang M, Chiu J, Scartelli C, Ponzar N, Patel S, Patel A, Ferreira RB, Keyes RF, Carroll KS, Pozzi N, Hogg PJ, Smith BC, Flaumenhaft R) J Thromb Haemost 2023 Aug;21(8):2137-2150 PMID: 37037379 PMCID: PMC10657653 SCOPUS ID: 2-s2.0-85158843043 04/11/2023       24 Citations
  • Harnessing the Noncanonical Keap1-Nrf2 Pathway for Human Cytomegalovirus Control. (Ghosh AK, Su YP, Forman M, Keyes RF, Smith BC, Hu X, Ferrer M, Arav-Boger R) J Virol 2023 Apr 27;97(4):e0016023 PMID: 36939350 PMCID: PMC10134830 SCOPUS ID: 2-s2.0-85159161803 03/21/2023       6 Citations
  • Fluorinated triphenylphosphonium analogs improve cell selectivity and in vivo detection of mito-metformin. (AbuEid M, Keyes RF, McAllister D, Peterson F, Kadamberi IP, Sprague DJ, Chaluvally-Raghavan P, Smith BC, Dwinell MB) iScience 2022 Dec 22;25(12):105670 PMID: 36567718 PMCID: PMC9768319 SCOPUS ID: 2-s2.0-85143723525 12/27/2022       11 Citations
  • Characterization of Dual-Acting A3 Adenosine Receptor Positive Allosteric Modulators That Preferentially Enhance Adenosine-Induced Gαi3 and GαoA Isoprotein Activation. (Fisher CL, Fallot LB, Wan TC, Keyes RF, Suresh RR, Rothwell AC, Gao ZG, McCorvy JD, Smith BC, Jacobson KA, Auchampach JA) ACS Pharmacol Transl Sci 2022 Aug 12;5(8):625-641 PMID: 35983277 PMCID: PMC9380209 SCOPUS ID: 2-s2.0-85135593508 08/20/2022       13 Citations
  • The Synthesis and Anti-Cytomegalovirus Activity of Piperidine-4-Carboxamides. (Guo X, Ghosh AK, Keyes RF, Peterson F, Forman M, Meyers DJ, Arav-Boger R) Viruses 2022 Jan 25;14(2) PMID: 35215828 PMCID: PMC8876412 SCOPUS ID: 2-s2.0-85123542102 02/27/2022       4 Citations
  • Validation and Characterization of Five Distinct Novel Inhibitors of Human Cytomegalovirus. (Kapoor A, Ghosh AK, Forman M, Hu X, Ye W, Southall N, Marugan J, Keyes RF, Smith BC, Meyers DJ, Ferrer M, Arav-Boger R) J Med Chem 2020 Apr 23;63(8):3896-3907 PMID: 32191456 PMCID: PMC7386824 SCOPUS ID: 2-s2.0-85084027851 03/20/2020       11 Citations
  • N-{3-[2-(4-alkoxyphenoxy)thiazol-5-yl]-1-methylprop-2-ynyl}carboxy derivatives as acetyl-coA carboxylase inhibitors--improvement of cardiovascular and neurological liabilities via structural modifications. (Gu YG, Weitzberg M, Clark RF, Xu X, Li Q, Lubbers NL, Yang Y, Beno DW, Widomski DL, Zhang T, Hansen TM, Keyes RF, Waring JF, Carroll SL, Wang X, Wang R, Healan-Greenberg CH, Blomme EA, Beutel BA, Sham HL, Camp HS) J Med Chem 2007 Mar 08;50(5):1078-82 PMID: 17298049 SCOPUS ID: 2-s2.0-33847792163 02/15/2007       35 Citations
  • The synthesis and structure-activity relationship studies of selective acetyl-CoA carboxylase inhibitors containing 4-(thiazol-5-yl)but-3-yn-2-amino motif: polar region modifications. (Xu X, Weitzberg M, Keyes RF, Li Q, Wang R, Wang X, Zhang X, Frevert EU, Camp HS, Beutel BA, Sham HL, Gu YG) Bioorg Med Chem Lett 2007 Mar 15;17(6):1803-7 PMID: 17234407 SCOPUS ID: 2-s2.0-33847070311 01/20/2007       20 Citations
  • An unusual intramolecular hetero-Diels-Alder cycloaddition. (Stoner EJ, Allen MS, Christesen AC, Henry RF, Hollis LS, Keyes R, Marsden I, Rehm TC, Shiroor SG, Soni NB, Stewart KD) J Org Chem 2005 Apr 15;70(8):3332-5 PMID: 15823010 SCOPUS ID: 2-s2.0-20244382566 04/13/2005       6 Citations
  • Short and efficient synthesis of a vinyl-substituted tricyclic erythromycin derivative. (Keyes RF, Carter JJ, Zhang X, Ma Z) Org Lett 2005 Mar 03;7(5):847-9 PMID: 15727456 SCOPUS ID: 2-s2.0-15044352772 02/25/2005       18 Citations
  • A scaleable synthesis of fiduxosin (Haight AR, Bailey AE, Baker WS, Cain MH, Copp RR, Demattei JA, Ford KL, Henry RF, Hsu MC, Keyes RF, King SA, McLaughlin MA, Melcher LM, Nadler WR, Oliver PA, Parekh SI, Patel HH, Seif LS, Staeger MA, Wayne GS, Wittenberger SJ, Zhang W) Organic Process Research and Development November 2004;8(6):897-902 SCOPUS ID: 2-s2.0-10044254548 11/01/2004       63 Citations
  • Synthesis and antibacterial activity of 6-O-arylbutynyl ketolides with improved activity against some key erythromycin-resistant pathogens. (Keyes RF, Carter JJ, Englund EE, Daly MM, Stone GG, Nilius AM, Ma Z) J Med Chem 2003 May 08;46(10):1795-8 PMID: 12723941 SCOPUS ID: 2-s2.0-0038416843 05/02/2003       52 Citations
  • Synthesis of mixed acyclic imides using pentafluorophenyl esters (Andrus MB, Li W, Keyes RF) Tetrahedron Letters 30 July 1998;39(31):5465-5468 SCOPUS ID: 2-s2.0-0032581746 07/30/1998       44 Citations
  • Synthesis of Microcolin B, a Potent New Immunosuppressant Using an Efficient Mixed Imide Formation Reaction (Andrus MB, Li W, Keyes RF) Journal of Organic Chemistry 1997;62(16):5542-5549 SCOPUS ID: 2-s2.0-0001271376 01/01/1997       79 Citations
  • Studies directed toward a more potent cosalane pharmacophore: Synthesis of a substituted tetraphenylethylene which inhibits the cytopathic effect of HIV-1 (Keyes RF, Cushman M) Medicinal Chemistry Research 1996;6(6):372-376 SCOPUS ID: 2-s2.0-0005950604 12/01/1996       6 Citations
  • Exploration of the effects of linker chain modifications on anti-HIV activities in a series of cosalane analogues. (Golebiewski WM, Keyes RF, Cushman M) Bioorg Med Chem 1996 Oct;4(10):1637-48 PMID: 8931933 SCOPUS ID: 2-s2.0-0030272456 10/01/1996       25 Citations
  • Correlation of anti-HIV potency with lipophilicity in a series of cosalane analogs having normal alkenyl and phosphodiester chains as cholestane replacements. (Keyes RF, Golebiewski WM, Cushman M) J Med Chem 1996 Jan 19;39(2):508-14 PMID: 8558520 SCOPUS ID: 2-s2.0-0030033216 01/19/1996       29 Citations
  • Carcinogenicity tests of fecapentaene-12 in mice and rats. (Weisburger JH, Jones RC, Wang CX, Backlund JY, Williams GM, Kingston DG, Van Tassell RL, Keyes RF, Wilkins TD, de Wit PP) Cancer Lett 1990 Feb;49(2):89-98 PMID: 2306713 SCOPUS ID: 2-s2.0-0025174949 02/01/1990       31 Citations
    • Last update: 07/24/2026