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Robert Lochhead PhD

Robert Lochhead PhD profile photo picture

Associate Professor

Institution: Medical College of Wisconsin
Department: Microbiology and Immunology

Member of the Cardiovascular Center
Member of the Center for Immunology

View Curriculum Vitae

Research Experience

  • Arthritis, Rheumatoid
  • Autoimmunity
  • Borrelia burgdorferi
  • Disease Models, Animal
  • Endothelial Cells
  • Fibroblasts
  • Gene Expression Regulation
  • Host-Pathogen Interactions
  • Inflammation
  • Lyme Disease
  • Lymphocytes
  • Myeloid Cells
  • Myocarditis
  • Osteoarthritis, Knee
  • COVID-19
  • SARS-CoV-2

    • MCW Program / Core Facilities

  • Center for Immunology
  • Center for Infectious Disease Research

    • Educational Expertise

  • Microbiology
  • immunology

    • Publications (22)

  • Peptidoglycan in osteoarthritis synovial tissue is associated with joint inflammation (Holub MN, Wahhab A, Rouse JR, Danner R, Hackner LG, Duris CB, McClune ME, Dressler JM, Strle K, Jutras BL, Edelstein AI, Lochhead RB) Arthritis Research and Therapy December 2024;26(1) SCOPUS ID: 2-s2.0-85188752768 12/01/2024    
  • Epitope expansion of Lyme autoantigen apoB-100 and CD4+ T cell responses to Borrelia burgdorferi Mcp4 are identified by immunopeptidomics profiling of murine models of Lyme arthritis. (Danner R, Pereckas M, Prochniak L, Rouse JR, Wahhab A, Hackner LG, Lochhead RB. ) Journal of Infection Diseases (revised manuscript under review) 05/29/2024    
  • Human leukocyte antigen HLA-DR-expressing fibroblast-like synoviocytes are inducible antigen presenting cells that present autoantigens in Lyme arthritis. (Rouse JR, Danner R, Wahhab A, Pereckas M, McClune ME, Steere AC, Strle K, Jutras BL, Lochhead RB) bioRxiv 2023 Nov 29 PMID: 38045407 PMCID: PMC10690166 12/04/2023    
  • Autoimmunity to synovial extracellular matrix proteins in patients with postinfectious Lyme arthritis. (Kanjana K, Strle K, Lochhead RB, Pianta A, Mateyka LM, Wang Q, Arvikar SL, Kling DE, Deangelo CA, Curham L, Barbour AG, Costello CE, Moon JJ, Steere AC) J Clin Invest 2023 Sep 01;133(17) PMID: 37471146 PMCID: PMC10471169 SCOPUS ID: 2-s2.0-85169502176 07/20/2023       10 Citations
  • Peptidoglycan in osteoarthritis synovial tissue is associated with joint inflammation. (Holub MN, Wahhab A, Rouse JR, Danner R, McClune MM, Dressler JM, Strle K, Jutras BL, Edelstein AI, Lochhead RB) Res Sq 2023 Apr 28 PMID: 37162851 PMCID: PMC10168439 05/10/2023    
  • Evidence of epitope spreading of Lyme autoantigen apoB-100 and identification of a novel immunogenic CD4+ T cell antigen from Borrelia burgdorferi using MHC class II immunopeptidomics analysis (Rebecca Danner, Michael Perekas, Joseph Rouse, Amanda Wahhab, and Robert Lochhead) Journal of Proteome Research (in prep) 03/29/2023    
  • Bacterial peptidoglycan is present in synovial tissue from osteoarthritis patients undergoing primary knee arthroplasty and is associated with joint inflammation (Meaghan Holub, Amanda Wahhab, Joseph Rouse, Rebecca Danner, Mecaila McClune, Jules Dressler, Brandon Jutras, Adam Edelstein, and Robert Lochhead) Arthritis and Rheumatology (in prep) 03/29/2023    
  • MHCII+ synovial fibroblasts act as inducible antigen presenting cells (Joseph Rouse, Amanda Wahhab, Rebecca Danner, and Robert Lochhead) Journal of Experimental Medicine (in prep) 03/29/2023    
  • Cell-Mediated Cytotoxicity in Lyme Arthritis. (Ordóñez D, Lochhead RB, Strle K, Pianta A, Arvikar S, Van Rhijn I, Stemmer-Rachamimov A, Steere AC) Arthritis Rheumatol 2023 May;75(5):782-793 PMID: 36413215 PMCID: PMC10191881 SCOPUS ID: 2-s2.0-85150932196 11/23/2022       5 Citations
  • Lyme arthritis: linking infection, inflammation and autoimmunity (Lochhead RB, Strle K, Arvikar SL, Weis JJ, Steere AC) Nature Reviews Rheumatology August 2021;17(8):449-461 SCOPUS ID: 2-s2.0-85109836229 08/01/2021       53 Citations
  • Lyme arthritis: linking infection, inflammation and autoimmunity. (Lochhead RB, Strle K, Arvikar SL, Weis JJ, Steere AC) Nat Rev Rheumatol 2021 Aug;17(8):449-461 PMID: 34226730 PMCID: PMC9488587 SCOPUS ID: 2-s2.0-85109836229 07/07/2021       53 Citations
  • Report of the Pathogenesis and Pathophysiology of Lyme Disease Subcommittee of the HHS Tick Borne Disease Working Group. (Donta ST, States LJ, Adams WA, Bankhead T, Baumgarth N, Embers ME, Lochhead RB, Stevenson B) Front Med (Lausanne) 2021;8:643235 PMID: 34164410 PMCID: PMC8215209 SCOPUS ID: 2-s2.0-85108307616 06/25/2021       9 Citations
  • Borrelia burgdorferi peptidoglycan is a persistent antigen in patients with Lyme arthritis. (Jutras BL, Lochhead RB, Kloos ZA, Biboy J, Strle K, Booth CJ, Govers SK, Gray J, Schumann P, Vollmer W, Bockenstedt LK, Steere AC, Jacobs-Wagner C) Proc Natl Acad Sci U S A 2019 Jul 02;116(27):13498-13507 PMID: 31209025 PMCID: PMC6613144 SCOPUS ID: 2-s2.0-85068263050 06/19/2019       101 Citations
  • Interferon-gamma production in Lyme arthritis synovial tissue promotes differentiation of fibroblast-like synoviocytes into immune effector cells. (Lochhead RB, Ordoñez D, Arvikar SL, Aversa JM, Oh LS, Heyworth B, Sadreyev R, Steere AC, Strle K) Cell Microbiol 2019 Feb;21(2):e12992 PMID: 30550623 PMCID: PMC6336510 SCOPUS ID: 2-s2.0-85059527799 12/15/2018       31 Citations
  • Robust interferon signature and suppressed tissue repair gene expression in synovial tissue from patients with postinfectious, Borrelia burgdorferi-induced Lyme arthritis. (Lochhead RB, Arvikar SL, Aversa JM, Sadreyev RI, Strle K, Steere AC) Cell Microbiol 2019 Feb;21(2):e12954 PMID: 30218476 PMCID: PMC6724218 SCOPUS ID: 2-s2.0-85055262062 09/16/2018       31 Citations
  • Correlation of Lyme Disease-Associated IgG4 Autoantibodies With Synovial Pathology in Antibiotic-Refractory Lyme Arthritis. (Sulka KB, Strle K, Crowley JT, Lochhead RB, Anthony R, Steere AC) Arthritis Rheumatol 2018 Nov;70(11):1835-1846 PMID: 29790305 PMCID: PMC6203610 SCOPUS ID: 2-s2.0-85053733387 05/24/2018       14 Citations
  • MicroRNA Expression Shows Inflammatory Dysregulation and Tumor-Like Proliferative Responses in Joints of Patients With Postinfectious Lyme Arthritis. (Lochhead RB, Strle K, Kim ND, Kohler MJ, Arvikar SL, Aversa JM, Steere AC) Arthritis Rheumatol 2017 May;69(5):1100-1110 PMID: 28076897 PMCID: PMC5406251 SCOPUS ID: 2-s2.0-85018719753 01/12/2017       32 Citations
  • Antagonistic Interplay between MicroRNA-155 and IL-10 during Lyme Carditis and Arthritis. (Lochhead RB, Zachary JF, Dalla Rosa L, Ma Y, Weis JH, O'Connell RM, Weis JJ) PLoS One 2015;10(8):e0135142 PMID: 26252010 PMCID: PMC4529177 SCOPUS ID: 2-s2.0-84941978921 08/08/2015       22 Citations
  • Borrelia burgdorferi arthritis-associated locus Bbaa1 regulates Lyme arthritis and K/B×N serum transfer arthritis through intrinsic control of type I IFN production. (Ma Y, Bramwell KK, Lochhead RB, Paquette JK, Zachary JF, Weis JH, Teuscher C, Weis JJ) J Immunol 2014 Dec 15;193(12):6050-60 PMID: 25378596 PMCID: PMC4258437 SCOPUS ID: 2-s2.0-84916898548 11/08/2014       17 Citations
  • MicroRNA-146a provides feedback regulation of lyme arthritis but not carditis during infection with Borrelia burgdorferi. (Lochhead RB, Ma Y, Zachary JF, Baltimore D, Zhao JL, Weis JH, O'Connell RM, Weis JJ) PLoS Pathog 2014 Jun;10(6):e1004212 PMID: 24967703 PMCID: PMC4072785 SCOPUS ID: 2-s2.0-84903484100 06/27/2014       37 Citations
  • Endothelial cells and fibroblasts amplify the arthritogenic type I IFN response in murine Lyme disease and are major sources of chemokines in Borrelia burgdorferi-infected joint tissue. (Lochhead RB, Sonderegger FL, Ma Y, Brewster JE, Cornwall D, Maylor-Hagen H, Miller JC, Zachary JF, Weis JH, Weis JJ) J Immunol 2012 Sep 01;189(5):2488-501 PMID: 22851707 PMCID: PMC3424307 SCOPUS ID: 2-s2.0-84865441928 08/02/2012       33 Citations
  • Quorum sensing primes the oxidative stress response in the insect endosymbiont, Sodalis glossinidius. (Pontes MH, Babst M, Lochhead R, Oakeson K, Smith K, Dale C) PLoS One 2008;3(10):e3541 PMID: 18958153 PMCID: PMC2568817 SCOPUS ID: 2-s2.0-56149106746 10/30/2008       37 Citations
    • Last update: 05/28/2024