Medical College of Wisconsin
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Samuel Bobholz PhD

Assistant Professor

Institution: Medical College of Wisconsin
Department: Radiology

Member of the Cancer Center

View Curriculum Vitae

Research Areas of Interest

  • Brain
  • Glioblastoma
  • Glioma
  • Machine Learning
  • Magnetic Resonance Imaging

    • Publications (34)

  • Altered perivascular diffusivity in glioblastoma: integrating DTI-ALPS index with radio-pathomic and histopathologic correlates. (Nath B, Bobholz SA, Kim DC, Lowman AK, Duenweg SR, Winiarz A, Chao B, Kyereme F, Barrett M, Reecher HM, Connelly J, Mrachek EKS, Jacobsohn J, Krucoff MO, Tanhehco E, Agarwal M, Destiche D, Banerjee A, LaViolette PS) J Neurooncol 2026 Feb 21;177(1) PMID: 41721916 PMCID: PMC12924826 SCOPUS ID: 2-s2.0-105030585109 02/21/2026    
  • Radio-pathomic maps of histo-morphometric features trained with whole mount prostate histology distinguish prostate cancer on MP-MRI. (Duenweg SR, Bobholz SA, Lowman AK, Winiarz A, Nath B, Barrett MJ, Kyereme F, Vincent-Sheldon S, Bhatt K, Troy K, Kim M, Fair E, Iczkowski KA, Jacobsohn KM, Banerjee A, Hall WA, Nencka AS, LaViolette PS) medRxiv 2026 Jan 13 PMID: 41646780 PMCID: PMC12870569 02/06/2026    
  • Altered Perivascular Diffusivity in Glioblastoma:Integrating DTI-ALPS Index with Radio-Pathomicand Histopathologic Correlates. (Nath B, Bobholz SA, Kim DC, Lowman AK, Duenweg SR, Winiarz A, Chao B, Kyereme F, Barrett M, Reecher HM, Connelly J, S Mrachek EK, Jacobsohn J, Krucoff MO, T E, Mohit A, Daniel D, Banerjee A, LaViolette PS) Res Sq 2025 Dec 22 PMID: 41510293 PMCID: PMC12776489 01/09/2026    
  • Independent histological validation of MR-derived radio-pathomic maps of tumor cell density using image-guided biopsies in human brain tumors. (Nocera G, Sanvito F, Yao J, Oshima S, Bobholz SA, Teraishi A, Raymond C, Patel K, Everson RG, Liau LM, Connelly J, Castellano A, Mortini P, Salamon N, Cloughesy TF, LaViolette PS, Ellingson BM) J Neurooncol 2025 Oct;175(1):111-122 PMID: 40542949 PMCID: PMC12367939 SCOPUS ID: 2-s2.0-105008481709 06/21/2025    
  • Comparison of intensity normalization methods in prostate, brain, and breast cancer multi-parametric magnetic resonance imaging. (Duenweg SR, Bobholz SA, Lowman AK, Winiarz A, Nath B, Barrett MJ, Kyereme F, Vincent-Sheldon S, LaViolette P) Front Oncol 2025;15:1433444 PMID: 39990680 PMCID: PMC11842255 SCOPUS ID: 2-s2.0-85218684929 02/24/2025       3 Citations
  • Multi-site retrospective analysis of diffusion and perfusion magnetic resonance imaging correlates to glioma characteristics derived from radio-pathomic maps. (Bobholz SA, Aaronsen D, Winiarz A, Duenweg SR, Lowman AK, Flatley M, Kyereme F, Connelly J, Mrachek EKS, Krucoff MO, Banerjee A, LaViolette PS) Neuro Oncol 2025 Sep 08;27(7):1899-1909 PMID: 39960860 PMCID: PMC12417833 SCOPUS ID: 2-s2.0-105015499764 02/17/2025       4 Citations
  • Radio-pathomic estimates of cellular growth kinetics predict survival in recurrent glioblastoma. (Oshima S, Yao J, Bobholz S, Nagaraj R, Raymond C, Teraishi A, Guenther AM, Kim A, Sanvito F, Cho NS, Eldred BSC, Connelly JM, Nghiemphu PL, Lai A, Salamon N, Cloughesy TF, LaViolette PS, Ellingson BM) CNS Oncol 2024 Dec 31;13(1):2415285 PMID: 39535237 PMCID: PMC11562955 SCOPUS ID: 2-s2.0-85209813692 11/13/2024       3 Citations
  • Noninvasive Autopsy-Validated Tumor Probability Maps Identify Glioma Invasion Beyond Contrast Enhancement. (Bobholz SA, Lowman AK, Connelly JM, Duenweg SR, Winiarz A, Nath B, Kyereme F, Brehler M, Bukowy J, Coss D, Lupo JM, Phillips JJ, Ellingson BM, Krucoff MO, Mueller WM, Banerjee A, LaViolette PS) Neurosurgery 2024 Sep 01;95(3):537-547 PMID: 38501824 PMCID: PMC11302944 SCOPUS ID: 2-s2.0-85201436914 03/19/2024       9 Citations
  • Correction to: Radio-pathomic maps of glioblastoma identify phenotypes of non-enhancing tumor infiltration associated with bevacizumab treatment response. (Bobholz SA, Hoefs A, Hamburger J, Lowman AK, Winiarz A, Duenweg SR, Kyereme F, Connelly J, Coss D, Krucoff M, Banerjee A, LaViolette PS) J Neurooncol 2024 Apr;167(2):243 PMID: 38498261 PMCID: PMC11023959 SCOPUS ID: 2-s2.0-85187929260 03/19/2024    
  • Morphologic features of prostate cancer-encased native vessels: An image analysis study. (Fernandez Gonzalez De La Vega C, Duenweg S, Jain P, Rubenstein SI, Bobholz S, Barrett MJ, LaViolette PS, Iczkowski KA) Pathol Res Pract 2024 Apr;256:155239 PMID: 38461692 SCOPUS ID: 2-s2.0-85187233730 03/11/2024       1 Citation
  • Radio-pathomic maps of glioblastoma identify phenotypes of non-enhancing tumor infiltration associated with bevacizumab treatment response. (Bobholz SA, Hoefs A, Hamburger J, Lowman AK, Winiarz A, Duenweg SR, Kyereme F, Connelly J, Coss D, Krucoff M, Banerjee A, LaViolette PS) J Neurooncol 2024 Apr;167(2):233-241 PMID: 38372901 PMCID: PMC11024025 SCOPUS ID: 2-s2.0-85185314152 02/19/2024       8 Citations
  • Radio-pathomic maps of glioblastoma identify phenotypes of non-enhancing tumor infiltration associated with bevacizumab treatment response. (Bobholz SA, Hoefs A, Hamburger J, Lowman AK, Winiarz A, Duenweg SR, Kyereme F, Connelly J, Coss D, Krucoff M, Banerjee A, LaViolette PS) Res Sq 2024 Jan 08 PMID: 38260400 PMCID: PMC10802733 01/23/2024    
  • The ISMRM Open Science Initiative for Perfusion Imaging (OSIPI): Results from the OSIPI-Dynamic Contrast-Enhanced challenge. (Shalom ES, Kim H, van der Heijden RA, Ahmed Z, Patel R, Hormuth DA 2nd, DiCarlo JC, Yankeelov TE, Sisco NJ, Dortch RD, Stokes AM, Inglese M, Grech-Sollars M, Toschi N, Sahoo P, Singh A, Verma SK, Rathore DK, Kazerouni AS, Partridge SC, LoCastro E, Paudyal R, Wolansky IA, Shukla-Dave A, Schouten P, Gurney-Champion OJ, Jiřík R, Macíček O, Bartoš M, Vitouš J, Das AB, Kim SG, Bokacheva L, Mikheev A, Rusinek H, Berks M, Hubbard Cristinacce PL, Little RA, Cheung S, O'Connor JPB, Parker GJM, Moloney B, LaViolette PS, Bobholz S, Duenweg S, Virostko J, Laue HO, Sung K, Nabavizadeh A, Saligheh Rad H, Hu LS, Sourbron S, Bell LC, Fathi Kazerooni A) Magn Reson Med 2024 May;91(5):1803-1821 PMID: 38115695 SCOPUS ID: 2-s2.0-85180171278 12/20/2023       11 Citations
  • Quantitative Histomorphometric Features of Prostate Cancer Predict Patients Who Biochemically Recur Following Prostatectomy. (Duenweg SR, Brehler M, Lowman AK, Bobholz SA, Kyereme F, Winiarz A, Nath B, Iczkowski KA, Jacobsohn KM, LaViolette PS) Lab Invest 2023 Dec;103(12):100269 PMID: 37898290 PMCID: PMC10872376 SCOPUS ID: 2-s2.0-85181176849 10/29/2023       3 Citations
  • T2-Weighted MRI Radiomic Features Predict Prostate Cancer Presence and Eventual Biochemical Recurrence. (Duenweg SR, Bobholz SA, Barrett MJ, Lowman AK, Winiarz A, Nath B, Stebbins M, Bukowy J, Iczkowski KA, Jacobsohn KM, Vincent-Sheldon S, LaViolette PS) Cancers (Basel) 2023 Sep 06;15(18) PMID: 37760407 PMCID: PMC10526331 SCOPUS ID: 2-s2.0-85172781879 09/28/2023       16 Citations
  • Whole slide imaging (WSI) scanner differences influence optical and computed properties of digitized prostate cancer histology. (Duenweg SR, Bobholz SA, Lowman AK, Stebbins MA, Winiarz A, Nath B, Kyereme F, Iczkowski KA, LaViolette PS) J Pathol Inform 2023;14:100321 PMID: 37496560 PMCID: PMC10365953 SCOPUS ID: 2-s2.0-85164379475 07/27/2023       27 Citations
  • Comparison of a machine and deep learning model for automated tumor annotation on digitized whole slide prostate cancer histology. (Duenweg SR, Brehler M, Bobholz SA, Lowman AK, Winiarz A, Kyereme F, Nencka A, Iczkowski KA, LaViolette PS) PLoS One 2023;18(3):e0278084 PMID: 36928230 PMCID: PMC10019669 SCOPUS ID: 2-s2.0-85150250210 03/18/2023       8 Citations
  • Image Quality Evaluation in Dual-Energy CT of the Chest, Abdomen, and Pelvis in Obese Patients With Deep Learning Image Reconstruction. (Fair E, Profio M, Kulkarni N, Laviolette PS, Barnes B, Bobholz S, Levenhagen M, Ausman R, Griffin MO, Duvnjak P, Zorn AP, Foley WD) J Comput Assist Tomogr 2022 Jul-Aug 01;46(4):604-611 PMID: 35483100 SCOPUS ID: 2-s2.0-85134296786 04/29/2022       14 Citations
  • Radio-Pathomic Maps of Cell Density Identify Brain Tumor Invasion beyond Traditional MRI-Defined Margins. (Bobholz SA, Lowman AK, Brehler M, Kyereme F, Duenweg SR, Sherman J, McGarry SD, Cochran EJ, Connelly J, Mueller WM, Agarwal M, Banerjee A, LaViolette PS) AJNR Am J Neuroradiol 2022 May;43(5):682-688 PMID: 35422419 PMCID: PMC9089258 SCOPUS ID: 2-s2.0-85130001814 04/16/2022       24 Citations
  • Diffusion Restriction Comparison between Gleason 4 Fused Glands and Cribriform Glands within Patient Using Whole-Mount Prostate Pathology as Ground Truth. (Duenweg SR, Fang X, Bobholz SA, Lowman AK, Brehler M, Kyereme F, Iczkowski KA, Jacobsohn KM, Banerjee A, LaViolette PS) Tomography 2022 Mar 02;8(2):635-643 PMID: 35314630 PMCID: PMC8938782 SCOPUS ID: 2-s2.0-85125945301 03/23/2022       4 Citations
  • Multi-Site Concordance of Diffusion-Weighted Imaging Quantification for Assessing Prostate Cancer Aggressiveness. (McGarry SD, Brehler M, Bukowy JD, Lowman AK, Bobholz SA, Duenweg SR, Banerjee A, Hurrell SL, Malyarenko D, Chenevert TL, Cao Y, Li Y, You D, Fedorov A, Bell LC, Quarles CC, Prah MA, Schmainda KM, Taouli B, LoCastro E, Mazaheri Y, Shukla-Dave A, Yankeelov TE, Hormuth DA 2nd, Madhuranthakam AJ, Hulsey K, Li K, Huang W, Huang W, Muzi M, Jacobs MA, Solaiyappan M, Hectors S, Antic T, Paner GP, Palangmonthip W, Jacobsohn K, Hohenwalter M, Duvnjak P, Griffin M, See W, Nevalainen MT, Iczkowski KA, LaViolette PS) J Magn Reson Imaging 2022 Jun;55(6):1745-1758 PMID: 34767682 PMCID: PMC9095769 SCOPUS ID: 2-s2.0-85118887092 11/13/2021       11 Citations
  • Accurate segmentation of prostate cancer histomorphometric features using a weakly supervised convolutional neural network. (Bukowy JD, Foss H, McGarry SD, Lowman AK, Hurrell SL, Iczkowski KA, Banerjee A, Bobholz SA, Barrington A, Dayton A, Unteriner J, Jacobsohn K, See WA, Nevalainen MT, Nencka AS, Ethridge T, Jarrard DF, LaViolette PS) J Med Imaging (Bellingham) 2020 Sep;7(5):057501 PMID: 33062803 PMCID: PMC7550797 SCOPUS ID: 2-s2.0-85096654686 10/17/2020       8 Citations
  • Barriers to biomedical care for people with epilepsy in Uganda: A cross-sectional study. (Kaddumukasa MN, Kaddumukasa M, Kajumba M, Smith PJ, Bobholz S, Kakooza-Mwesige A, Sinha DD, Almojuela A, Chakraborty P, Nakasujja N, Nakku J, Gualtieri A, Onuoha E, Kolls BJ, Muhumuza C, Smith CE, Sanchez N, Fuller AT, Haglund MM, Koltai DC) Epilepsy Behav 2021 Jan;114(Pt B):107349 PMID: 32962922 SCOPUS ID: 2-s2.0-85088936893 09/24/2020       13 Citations
  • Radio-pathomic mapping model generated using annotations from five pathologists reliably distinguishes high-grade prostate cancer. (McGarry SD, Bukowy JD, Iczkowski KA, Lowman AK, Brehler M, Bobholz S, Nencka A, Barrington A, Jacobsohn K, Unteriner J, Duvnjak P, Griffin M, Hohenwalter M, Keuter T, Huang W, Antic T, Paner G, Palangmonthip W, Banerjee A, LaViolette PS) J Med Imaging (Bellingham) 2020 Sep;7(5):054501 PMID: 32923510 PMCID: PMC7479263 SCOPUS ID: 2-s2.0-85096616055 09/15/2020       15 Citations
  • Prospective study of the association between sport-related concussion and brain morphometry (3T-MRI) in collegiate athletes: study from the NCAA-DoD CARE Consortium. (Bobholz SA, Brett BL, España LY, Huber DL, Mayer AR, Harezlak J, Broglio SP, McAllister T, McCrea MA, Meier TB, CARE Consortium Investigators) Br J Sports Med 2021 Feb;55(3):169-174 PMID: 32917671 PMCID: PMC7855484 SCOPUS ID: 2-s2.0-85095693842 09/13/2020       15 Citations
  • Cumulative Effects of Prior Concussion and Primary Sport Participation on Brain Morphometry in Collegiate Athletes: A Study From the NCAA-DoD CARE Consortium. (Brett BL, Bobholz SA, España LY, Huber DL, Mayer AR, Harezlak J, Broglio SP, McAllister TW, McCrea MA, Meier TB, CARE Consortium Investigators) Front Neurol 2020;11:673 PMID: 32849177 PMCID: PMC7399344 SCOPUS ID: 2-s2.0-85089425603 08/28/2020       27 Citations
  • Pluralistic and singular causal attributions for epilepsy in Uganda. (Smith CE, Kajumba M, Bobholz S, Smith PJ, Kaddumukasa M, Kakooza-Mwesige A, Chakraborty P, Sinha DD, Kaddumukasa MN, Gualtieri A, Nakasujja N, Onuoha E, Nakku J, Muhumuza C, Sanchez N, Fuller AT, Haglund MM, Koltai DC) Epilepsy Behav 2021 Jan;114(Pt B):107334 PMID: 32839144 SCOPUS ID: 2-s2.0-85088936344 08/26/2020       7 Citations
  • Sociocultural determinants and patterns of healthcare utilization for epilepsy care in Uganda. (Koltai DC, Dunn TW, Smith PJ, Sinha DD, Bobholz S, Kaddumukasa M, Kakooza-Mwesige A, Kajumba M, Smith CE, Kaddumukasa MN, Teuwen DE, Nakasujja N, Chakraborty P, Kolls BJ, Nakku J, Haglund MM, Fuller AT) Epilepsy Behav 2021 Jan;114(Pt B):107304 PMID: 32768344 SCOPUS ID: 2-s2.0-85088948156 08/10/2020       12 Citations
  • Epilepsy beliefs and misconceptions among patient and community samples in Uganda. (Kaddumukasa M, Smith PJ, Kaddumukasa MN, Kajumba M, Almojuela A, Bobholz S, Chakraborty P, Sinha DD, Nakasujja N, Kakooza-Mwesige A, Gualtieri A, Onuoha E, Nakku J, Sanchez N, Muhumuza C, Fuller AT, Haglund MM, Koltai DC) Epilepsy Behav 2021 Jan;114(Pt B):107300 PMID: 32758405 SCOPUS ID: 2-s2.0-85088932090 08/08/2020       15 Citations
  • Stakeholder views of the practical and cultural barriers to epilepsy care in Uganda. (Sanchez N, Kajumba M, Kalyegira J, Sinha DD, Bobholz S, Gualtieri A, Chakraborty P, Onuoha E, Fuller AT, Teuwen DE, Haglund MM, Koltai DC) Epilepsy Behav 2021 Jan;114(Pt B):107314 PMID: 32758404 SCOPUS ID: 2-s2.0-85088965114 08/08/2020       9 Citations
  • Radiomic Features of Multiparametric MRI Present Stable Associations With Analogous Histological Features in Patients With Brain Cancer. (Bobholz SA, Lowman AK, Barrington A, Brehler M, McGarry S, Cochran EJ, Connelly J, Mueller WM, Agarwal M, O'Neill D, Nencka AS, Banerjee A, LaViolette PS) Tomography 2020 Jun;6(2):160-169 PMID: 32548292 PMCID: PMC7289245 SCOPUS ID: 2-s2.0-85086686895 06/18/2020       40 Citations
  • Corpora amylacea in benign prostatic acini are associated with concurrent, predominantly low-grade cancer. (Palangmonthip W, Wu R, Tarima S, Bobholz SA, LaViolette PS, Gallan AJ, Iczkowski KA) Prostate 2020 Jun;80(9):687-697 PMID: 32271960 PMCID: PMC10561550 SCOPUS ID: 2-s2.0-85083052266 04/10/2020       8 Citations
  • Neurobiological substrates of processing speed in childhood epilepsy. (Bobholz SA, Dabbs K, Almane D, Jones JE, Hsu DE, Stafstrom CE, Seidenberg M, Hermann BP) Brain Imaging Behav 2019 Dec;13(6):1719-1725 PMID: 30511113 SCOPUS ID: 2-s2.0-85058958489 12/05/2018       7 Citations
  • Brain structure and organization five decades after childhood onset epilepsy. (Garcia-Ramos C, Bobholz S, Dabbs K, Hermann B, Joutsa J, Rinne JO, Karrasch M, Prabhakaran V, Shinnar S, Sillanpää M, TACOE Study Group) Hum Brain Mapp 2017 Jun;38(6):3289-3299 PMID: 28370719 PMCID: PMC5479770 SCOPUS ID: 2-s2.0-85017182350 04/04/2017       14 Citations
    • Last update: 05/08/2026