Shirng-Wern Tsaih
Research Scientist II
Institution: Medical College of Wisconsin
Department: Obstetrics and Gynecology
Division: Research and Advanced Education
Program: Medical Education and Research
Send Message
Request Meeting
Research Experience
Disease Models, AnimalGene Expression ProfilingGenes, ModifierGenetic VariationGenome-Wide Association StudyGenomicsQuantitative Trait LociSequence Analysis, DNATumor MicroenvironmentPublications (98)
Machine learning reveals genetic modifiers of the immune microenvironment of cancer. (Riley-Gillis B, Tsaih SW, King E, Wollenhaupt S, Reeb J, Peck AR, Wackman K, Lemke A, Rui H, Dezso Z, Flister MJ) iScience 2023 Sep 15;26(9):107576 PMID: 37664640 PMCID: PMC10470213 SCOPUS ID: 2-s2.0-85170216683 09/04/2023 Frequent upregulation of HER2 protein in hormone-receptor-positive HER2-negative breast cancer after short-term neoadjuvant endocrine therapy. (Chaudhary LN, Jorns JM, Sun Y, Cheng YC, Kamaraju S, Burfeind J, Gonyo MB, Kong AL, Patten C, Yen T, Cortina CS, Carson E, Johnson N, Bergom C, Tsaih SW, Banerjee A, Wang Y, Chervoneva I, Weil E, Chitambar CR, Rui H) Breast Cancer Res Treat 2023 Oct;201(3):387-396 PMID: 37460683 PMCID: PMC10795510 SCOPUS ID: 2-s2.0-85164922339 07/18/2023 2 CitationsNNAT is a novel mediator of oxidative stress that suppresses ER + breast cancer. (Plasterer C, Semenikhina M, Tsaih SW, Flister MJ, Palygin O) Mol Med 2023 Jul 03;29(1):87 PMID: 37400769 PMCID: PMC10318825 SCOPUS ID: 2-s2.0-85163976482 07/04/2023 Effect of a Best-Practice Alert on the Rate of Smoking Cessation among Pregnant Women. (Tvina A, Tillis B, Chen M, MacBeth M, Tsaih SW, Palatnik A) Am J Perinatol 2023 Jun 06 PMID: 37168019 SCOPUS ID: 2-s2.0-85163206383 05/12/2023 Frequent Upregulation Of HER2 Protein In Hormone Receptor-Positive HER2-Negative Breast Cancer After Short-Term Neoadjuvant Endocrine Therapy. (Chaudhary LN, Jorns J, Sun Y, Cheng YC, Kamaraju S, Burfeind J, Gonyo M, Kong A, Patten C, Yen T, Cortina C, Carson E, Johnson N, Bergom C, Tsaih SW, Banerjee A, Wang Y, Chervoneva I, Weil E, Chitambar CR, Rui H) Res Sq 2023 Apr 07 PMID: 37066270 PMCID: PMC10104267 04/18/2023 HLA antibodies in fetal and neonatal alloimmune thrombocytopenia. (Colvin ZA, Schiller J, Tsaih SW, Sharma R, Grace RF, McIntosh JJ, Curtis BR) Transfusion 2023 Jun;63(6):1141-1149 PMID: 37038316 SCOPUS ID: 2-s2.0-85152374372 04/12/2023 RNA-binding protein FXR1 drives cMYC translation by recruiting eIF4F complex to the translation start site. (George J, Li Y, Kadamberi IP, Parashar D, Tsaih SW, Gupta P, Geethadevi A, Chen C, Ghosh C, Sun Y, Mittal S, Ramchandran R, Rui H, Lopez-Berestein G, Rodriguez-Aguayo C, Leone G, Rader JS, Sood AK, Dey M, Pradeep S, Chaluvally-Raghavan P) Cell Rep 2023 Mar 28;42(3):112228 PMID: 36884347 PMCID: PMC10233815 SCOPUS ID: 2-s2.0-85149682952 03/09/2023 Impact of prior gestational diabetes on long-term type 2 diabetes complications. (Cui Y, Marshall A, Tsaih SW, Palatnik A) J Diabetes Complications 2022 Sep;36(9):108282 PMID: 35933918 SCOPUS ID: 2-s2.0-85135685598 08/08/2022 Pathophysiological role of NNAT in ER+ breast cancer. (Semenikhina M, Plasterer C, Tsaih SW, Flister M, Palygin O) FASEB J 2022 May;36 Suppl 1 PMID: 35560520 SCOPUS ID: 2-s2.0-85130050740 05/14/2022 Tumor Derived Extracellular Vesicles Drive T Cell Exhaustion in Tumor Microenvironment through Sphingosine Mediated Signaling and Impacting Immunotherapy Outcomes in Ovarian Cancer. (Gupta P, Kadamberi IP, Mittal S, Tsaih SW, George J, Kumar S, Vijayan DK, Geethadevi A, Parashar D, Topchyan P, McAlarnen L, Volkman BF, Cui W, Zhang KYJ, Di Vizio D, Chaluvally-Raghavan P, Pradeep S) Adv Sci (Weinh) 2022 May;9(14):e2104452 PMID: 35289120 PMCID: PMC9108620 SCOPUS ID: 2-s2.0-85126251446 03/16/2022 25 CitationsRacial and Ethnic Disparities in Maternal and Neonatal Outcomes among Women with Chronic Hypertension. (Stearns K, Tsaih SW, Palatnik A) Am J Perinatol 2022 Jul;39(10):1033-1041 PMID: 35045577 SCOPUS ID: 2-s2.0-85126038352 01/20/2022 2 CitationsRNA-binding protein FXR1 drives cMYC translation by recruiting eIF4F complex to the translation start site. (George J, Li Y, Kadamberi IP, Parashar D, Tsaih SW, Gupta P, Geethadevi A, Chen C, Ghosh C, Sun Y, Mittal S, Ramchandran R, Rui H, Lopez-Berestein G, Rodriguez-Aguayo C, Leone G, Rader JS, Sood AK, Dey M, Pradeep S, Chaluvally-Raghavan P) Cell Rep 2021 Nov 02;37(5):109934 PMID: 34731628 PMCID: PMC8675433 SCOPUS ID: 2-s2.0-85118477211 11/04/2021 29 CitationsMulti-omics mapping of human papillomavirus integration sites illuminates novel cervical cancer target genes. (Iden M, Tsaih SW, Huang YW, Liu P, Xiao M, Flister MJ, Rader JS) Br J Cancer 2021 Nov;125(10):1408-1419 PMID: 34526665 PMCID: PMC8575955 SCOPUS ID: 2-s2.0-85115169639 09/17/2021 7 CitationsNSG-Pro mouse model for uncovering resistance mechanisms and unique vulnerabilities in human luminal breast cancers. (Sun Y, Yang N, Utama FE, Udhane SS, Zhang J, Peck AR, Yanac A, Duffey K, Langenheim JF, Udhane V, Xia G, Peterson JF, Jorns JM, Nevalainen MT, Rouet R, Schofield P, Christ D, Ormandy CJ, Rosenberg AL, Chervoneva I, Tsaih SW, Flister MJ, Fuchs SY, Wagner KU, Rui H) Sci Adv 2021 Sep 17;7(38):eabc8145 PMID: 34524841 PMCID: PMC8443188 SCOPUS ID: 2-s2.0-85115168052 09/16/2021 7 CitationsVirtual visits among gynecologic oncology patients during the COVID-19 pandemic are accessible across the social vulnerability spectrum. (McAlarnen LA, Tsaih SW, Aliani R, Simske NM, Hopp EE) Gynecol Oncol 2021 Jul;162(1):4-11 PMID: 33994014 PMCID: PMC8111476 SCOPUS ID: 2-s2.0-85105799766 05/18/2021 16 CitationsResidential proximity to tree canopy and preterm birth in Black women. (Tvina A, Visser A, Walker SL, Tsaih SW, Zhou Y, Beyer K, Palatnik A) Am J Obstet Gynecol MFM 2021 Sep;3(5):100391 PMID: 33984532 SCOPUS ID: 2-s2.0-85116173141 05/14/2021 7 CitationsPeritoneal Spread of Ovarian Cancer Harbors Therapeutic Vulnerabilities Regulated by FOXM1 and EGFR/ERBB2 Signaling. (Parashar D, Nair B, Geethadevi A, George J, Nair A, Tsaih SW, Kadamberi IP, Gopinadhan Nair GK, Lu Y, Ramchandran R, Uyar DS, Rader JS, Ram PT, Mills GB, Pradeep S, Chaluvally-Raghavan P) Cancer Res 2020 Dec 15;80(24):5554-5568 PMID: 33087324 PMCID: PMC7744365 SCOPUS ID: 2-s2.0-85100331032 10/23/2020 25 CitationsConditional Deletion of PGC-1α Results in Energetic and Functional Defects in NK Cells. (Gerbec ZJ, Hashemi E, Nanbakhsh A, Holzhauer S, Yang C, Mei A, Tsaih SW, Lemke A, Flister MJ, Riese MJ, Thakar MS, Malarkannan S) iScience 2020 Sep 25;23(9):101454 PMID: 32858341 PMCID: PMC7474003 SCOPUS ID: 2-s2.0-85089821937 08/29/2020 9 CitationsThe medical transition of young adults with type 1 diabetes (T1D): a retrospective chart review identifies areas in need of improvement. (Walch AM, Cobb CE, Tsaih SW, Cabrera SM) Int J Pediatr Endocrinol 2020;2020:10 PMID: 32514267 PMCID: PMC7254679 06/10/2020 Differences in Expression of Mitochondrial Complexes Due to Genetic Variants May Alter Sensitivity to Radiation-Induced Cardiac Dysfunction. (Schlaak RA, Frei A, SenthilKumar G, Tsaih SW, Wells C, Mishra J, Flister MJ, Camara AKS, Bergom C) Front Cardiovasc Med 2020;7:23 PMID: 32195269 PMCID: PMC7066205 SCOPUS ID: 2-s2.0-85109301042 03/21/2020 10 CitationsERBB3-induced furin promotes the progression and metastasis of ovarian cancer via the IGF1R/STAT3 signaling axis. (Chen C, Gupta P, Parashar D, Nair GG, George J, Geethadevi A, Wang W, Tsaih SW, Bradley W, Ramchandran R, Rader JS, Chaluvally-Raghavan P, Pradeep S) Oncogene 2020 Apr;39(14):2921-2933 PMID: 32029900 PMCID: PMC7346970 SCOPUS ID: 2-s2.0-85079196544 02/08/2020 27 CitationsSplice switching an oncogenic ratio of SmgGDS isoforms as a strategy to diminish malignancy. (Brandt AC, McNally L, Lorimer EL, Unger B, Koehn OJ, Suazo KF, Rein L, Szabo A, Tsaih SW, Distefano MD, Flister MJ, Rigo F, McNally MT, Williams CL) Proc Natl Acad Sci U S A 2020 Feb 18;117(7):3627-3636 PMID: 32019878 PMCID: PMC7035473 SCOPUS ID: 2-s2.0-85079538992 02/06/2020 17 CitationsMirc11 Disrupts Inflammatory but Not Cytotoxic Responses of NK Cells. (Nanbakhsh A, Srinivasamani A, Holzhauer S, Riese MJ, Zheng Y, Wang D, Burns R, Reimer MH, Rao S, Lemke A, Tsaih SW, Flister MJ, Lao S, Dahl R, Thakar MS, Malarkannan S) Cancer Immunol Res 2019 Oct;7(10):1647-1662 PMID: 31515257 PMCID: PMC7428857 SCOPUS ID: 2-s2.0-85072848720 09/14/2019 10 CitationsThe p52 isoform of SHC1 is a key driver of breast cancer initiation. (Wright KD, Miller BS, El-Meanawy S, Tsaih SW, Banerjee A, Geurts AM, Sheinin Y, Sun Y, Kalyanaraman B, Rui H, Flister MJ, Sorokin A) Breast Cancer Res 2019 Jun 15;21(1):74 PMID: 31202267 PMCID: PMC6570928 SCOPUS ID: 2-s2.0-85067234098 06/17/2019 25 CitationsNeuronatin is a modifier of estrogen receptor-positive breast cancer incidence and outcome. (Plasterer C, Tsaih SW, Peck AR, Chervoneva I, O'Meara C, Sun Y, Lemke A, Murphy D, Smith J, Ran S, Kovatich AJ, Hooke JA, Shriver CD, Hu H, Mitchell EP, Bergom C, Joshi A, Auer P, Prokop J, Rui H, Flister MJ) Breast Cancer Res Treat 2019 Aug;177(1):77-91 PMID: 31165373 PMCID: PMC10317546 SCOPUS ID: 2-s2.0-85066986189 06/06/2019 3 CitationsMitochondrial Oxidative Phosphorylation defect in the Heart of Subjects with Coronary Artery Disease. (Ait-Aissa K, Blaszak SC, Beutner G, Tsaih SW, Morgan G, Santos JH, Flister MJ, Joyce DL, Camara AKS, Gutterman DD, Donato AJ, Porter GA Jr, Beyer AM) Sci Rep 2019 May 20;9(1):7623 PMID: 31110224 PMCID: PMC6527853 SCOPUS ID: 2-s2.0-85066048228 05/22/2019 55 CitationsIdentification of a Rat Mammary Tumor Risk Locus That Is Syntenic with the Commonly Amplified 8q12.1 and 8q22.1 Regions in Human Breast Cancer Patients. (Plasterer C, Tsaih SW, Lemke A, Schilling R, Dwinell M, Rau A, Auer P, Rui H, Flister MJ) G3 (Bethesda) 2019 May 07;9(5):1739-1743 PMID: 30914425 PMCID: PMC6505137 SCOPUS ID: 2-s2.0-85065792535 03/28/2019 4 CitationsMapping genetic modifiers of radiation-induced cardiotoxicity to rat chromosome 3. (Schlaak RA, Frei A, Schottstaedt AM, Tsaih SW, Fish BL, Harmann L, Liu Q, Gasperetti T, Medhora M, North PE, Strande JL, Sun Y, Rui H, Flister MJ, Bergom C) Am J Physiol Heart Circ Physiol 2019 Jun 01;316(6):H1267-H1280 PMID: 30848680 PMCID: PMC6620678 SCOPUS ID: 2-s2.0-85066837925 03/09/2019 29 CitationsGenetic variations in human papillomavirus and cervical cancer outcomes. (Rader JS, Tsaih SW, Fullin D, Murray MW, Iden M, Zimmermann MT, Flister MJ) Int J Cancer 2019 May 01;144(9):2206-2214 PMID: 30515767 PMCID: PMC6450540 SCOPUS ID: 2-s2.0-85059541854 12/06/2018 20 CitationsMitochondria-Targeted Honokiol Confers a Striking Inhibitory Effect on Lung Cancer via Inhibiting Complex I Activity. (Pan J, Lee Y, Cheng G, Zielonka J, Zhang Q, Bajzikova M, Xiong D, Tsaih SW, Hardy M, Flister M, Olsen CM, Wang Y, Vang O, Neuzil J, Myers CR, Kalyanaraman B, You M) iScience 2018 May 25;3:192-207 PMID: 30428319 PMCID: PMC6137433 SCOPUS ID: 2-s2.0-85063413951 11/15/2018 41 CitationsIL-13 promotes in vivo neonatal cardiomyocyte cell cycle activity and heart regeneration. (Wodsedalek DJ, Paddock SJ, Wan TC, Auchampach JA, Kenarsary A, Tsaih SW, Flister MJ, O'Meara CC) Am J Physiol Heart Circ Physiol 2019 Jan 01;316(1):H24-H34 PMID: 30339498 SCOPUS ID: 2-s2.0-85060194313 10/20/2018 32 CitationsmTORC1 and mTORC2 differentially promote natural killer cell development. (Yang C, Tsaih SW, Lemke A, Flister MJ, Thakar MS, Malarkannan S) Elife 2018 May 29;7 PMID: 29809146 PMCID: PMC5976438 SCOPUS ID: 2-s2.0-85051988950 05/29/2018 48 CitationsA High-Resolution Genetic Map for the Laboratory Rat. (Littrell J, Tsaih SW, Baud A, Rastas P, Solberg-Woods L, Flister MJ) G3 (Bethesda) 2018 Jul 02;8(7):2241-2248 PMID: 29760201 PMCID: PMC6027877 SCOPUS ID: 2-s2.0-85049401734 05/16/2018 13 CitationsGenetic Fine-Mapping and Identification of Candidate Genes and Variants for Adiposity Traits in Outbred Rats. (Keele GR, Prokop JW, He H, Holl K, Littrell J, Deal A, Francic S, Cui L, Gatti DM, Broman KW, Tschannen M, Tsaih SW, Zagloul M, Kim Y, Baur B, Fox J, Robinson M, Levy S, Flister MJ, Mott R, Valdar W, Solberg Woods LC) Obesity (Silver Spring) 2018 Jan;26(1):213-222 PMID: 29193816 PMCID: PMC5740008 SCOPUS ID: 2-s2.0-85036513924 12/02/2017 46 CitationsSmgGDS is a transient nucleolar protein that protects cells from nucleolar stress and promotes the cell cycle by regulating DREAM complex gene expression. (Gonyo P, Bergom C, Brandt AC, Tsaih SW, Sun Y, Bigley TM, Lorimer EL, Terhune SS, Rui H, Flister MJ, Long RM, Williams CL) Oncogene 2017 Dec 14;36(50):6873-6883 PMID: 28806394 PMCID: PMC5730474 SCOPUS ID: 2-s2.0-85038242723 08/15/2017 12 CitationsHost genetic modifiers of nonproductive angiogenesis inhibit breast cancer. (Flister MJ, Tsaih SW, Stoddard A, Plasterer C, Jagtap J, Parchur AK, Sharma G, Prisco AR, Lemke A, Murphy D, Al-Gizawiy M, Straza M, Ran S, Geurts AM, Dwinell MR, Greene AS, Bergom C, LaViolette PS, Joshi A) Breast Cancer Res Treat 2017 Aug;165(1):53-64 PMID: 28567545 PMCID: PMC6404538 SCOPUS ID: 2-s2.0-85020059895 06/02/2017 15 CitationsThe phenotypic impact of the male-specific region of chromosome-Y in inbred mating: the role of genetic variants and gene duplications in multiple inbred rat strains. (Prokop JW, Tsaih SW, Faber AB, Boehme S, Underwood AC, Troyer S, Playl L, Milsted A, Turner ME, Ely D, Martins AS, Tutaj M, Lazar J, Dwinell MR, Jacob HJ) Biol Sex Differ 2016;7:10 PMID: 26848384 PMCID: PMC4740989 SCOPUS ID: 2-s2.0-84957567774 02/06/2016 13 CitationsA locus on mouse chromosome 13 inversely regulates CD1d expression and the development of invariant natural killer T-cells. (Tsaih SW, Presa M, Khaja S, Ciecko AE, Serreze DV, Chen YG) Genes Immun 2015;16(3):221-30 PMID: 25654212 PMCID: PMC4409484 SCOPUS ID: 2-s2.0-84928582595 02/06/2015 7 CitationsSH2B3 Is a Genetic Determinant of Cardiac Inflammation and Fibrosis. (Flister MJ, Hoffman MJ, Lemke A, Prisco SZ, Rudemiller N, O'Meara CC, Tsaih SW, Moreno C, Geurts AM, Lazar J, Adhikari N, Hall JL, Jacob HJ) Circ Cardiovasc Genet 2015 Apr;8(2):294-304 PMID: 25628389 SCOPUS ID: 2-s2.0-84942919523 01/30/2015 21 CitationsIdentification of a novel gene for diabetic traits in rats, mice, and humans. (Tsaih SW, Holl K, Jia S, Kaldunski M, Tschannen M, He H, Andrae JW, Li SH, Stoddard A, Wiederhold A, Parrington J, Ruas da Silva M, Galione A, Meigs J, Meta-Analyses of Glucose and Insulin-Related Traits Consortium (MAGIC) Investigators, Hoffmann RG, Simpson P, Jacob H, Hessner M, Solberg Woods LC) Genetics 2014 Sep;198(1):17-29 PMID: 25236446 PMCID: PMC4174929 SCOPUS ID: 2-s2.0-84907982004 09/23/2014 36 CitationsCXM: a new tool for mapping breast cancer risk in the tumor microenvironment. (Flister MJ, Endres BT, Rudemiller N, Sarkis AB, Santarriaga S, Roy I, Lemke A, Geurts AM, Moreno C, Ran S, Tsaih SW, De Pons J, Carlson DF, Tan W, Fahrenkrug SC, Lazarova Z, Lazar J, North PE, LaViolette PS, Dwinell MB, Shull JD, Jacob HJ) Cancer Res 2014 Nov 15;74(22):6419-29 PMID: 25172839 PMCID: PMC4247541 SCOPUS ID: 2-s2.0-84918497707 08/31/2014 25 CitationsIdentifying multiple causative genes at a single GWAS locus. (Flister MJ, Tsaih SW, O'Meara CC, Endres B, Hoffman MJ, Geurts AM, Dwinell MR, Lazar J, Jacob HJ, Moreno C) Genome Res 2013 Dec;23(12):1996-2002 PMID: 24006081 PMCID: PMC3847770 SCOPUS ID: 2-s2.0-84888132259 09/06/2013 86 CitationsGenomics in clinical practice: lessons from the front lines. (Jacob HJ, Abrams K, Bick DP, Brodie K, Dimmock DP, Farrell M, Geurts J, Harris J, Helbling D, Joers BJ, Kliegman R, Kowalski G, Lazar J, Margolis DA, North P, Northup J, Roquemore-Goins A, Scharer G, Shimoyama M, Strong K, Taylor B, Tsaih SW, Tschannen MR, Veith RL, Wendt-Andrae J, Wilk B, Worthey EA) Sci Transl Med 2013 Jul 17;5(194):194cm5 PMID: 23863829 SCOPUS ID: 2-s2.0-84880547053 07/19/2013 80 CitationsGenetic control of murine invariant natural killer T cells maps to multiple type 1 diabetes regions. (Tsaih SW, Khaja S, Ciecko AE, MacKinney E, Chen YG) Genes Immun 2013 Sep;14(6):380-6 PMID: 23719031 PMCID: PMC3766462 SCOPUS ID: 2-s2.0-84883850847 05/31/2013 4 CitationsIncreased proliferative cells in the medullary thick ascending limb of the loop of Henle in the Dahl salt-sensitive rat. (Yang C, Stingo FC, Ahn KW, Liu P, Vannucci M, Laud PW, Skelton M, O'Connor P, Kurth T, Ryan RP, Moreno C, Tsaih SW, Patone G, Hummel O, Jacob HJ, Liang M, Cowley AW Jr) Hypertension 2013 Jan;61(1):208-15 PMID: 23184381 PMCID: PMC3760736 SCOPUS ID: 2-s2.0-84871619201 11/28/2012 18 CitationsFine-mapping diabetes-related traits, including insulin resistance, in heterogeneous stock rats. (Solberg Woods LC, Holl KL, Oreper D, Xie Y, Tsaih SW, Valdar W) Physiol Genomics 2012 Nov 01;44(21):1013-26 PMID: 22947656 PMCID: PMC3524769 SCOPUS ID: 2-s2.0-84868566945 09/06/2012 35 CitationsGenetic analysis of albuminuria in collaborative cross and multiple mouse intercross populations. (Thaisz J, Tsaih SW, Feng M, Philip VM, Zhang Y, Yanas L, Sheehan S, Xu L, Miller DR, Paigen B, Chesler EJ, Churchill GA, Dipetrillo K) Am J Physiol Renal Physiol 2012 Oct;303(7):F972-81 PMID: 22859403 PMCID: PMC3469684 SCOPUS ID: 2-s2.0-84867136843 08/04/2012 18 CitationsSubcongenic analyses reveal complex interactions between distal chromosome 4 genes controlling diabetogenic B cells and CD4 T cells in nonobese diabetic mice. (Stolp J, Chen YG, Cox SL, Henck V, Zhang W, Tsaih SW, Chapman H, Stearns T, Serreze DV, Silveira PA) J Immunol 2012 Aug 01;189(3):1406-17 PMID: 22732593 PMCID: PMC3401322 SCOPUS ID: 2-s2.0-84864150616 06/27/2012 11 CitationsRole of genetic modifiers in an orthologous rat model of ARPKD. (O'Meara CC, Hoffman M, Sweeney WE Jr, Tsaih SW, Xiao B, Jacob HJ, Avner ED, Moreno C) Physiol Genomics 2012 Aug 01;44(15):741-53 PMID: 22669842 PMCID: PMC3774585 SCOPUS ID: 2-s2.0-84865616207 06/07/2012 22 CitationsGenetic coregulation of age of female sexual maturation and lifespan through circulating IGF1 among inbred mouse strains. (Yuan R, Meng Q, Nautiyal J, Flurkey K, Tsaih SW, Krier R, Parker MG, Harrison DE, Paigen B) Proc Natl Acad Sci U S A 2012 May 22;109(21):8224-9 PMID: 22566614 PMCID: PMC3361401 SCOPUS ID: 2-s2.0-84861448087 05/09/2012 86 CitationsUsing bioinformatics and systems genetics to dissect HDL-cholesterol genetics in an MRL/MpJ x SM/J intercross. (Leduc MS, Blair RH, Verdugo RA, Tsaih SW, Walsh K, Churchill GA, Paigen B) J Lipid Res 2012 Jun;53(6):1163-75 PMID: 22498810 PMCID: PMC3351823 SCOPUS ID: 2-s2.0-84861437612 04/14/2012 11 CitationsGenetic variation in TRPS1 may regulate hip geometry as well as bone mineral density. (Ackert-Bicknell CL, Demissie S, Tsaih SW, Beamer WG, Cupples LA, Paigen BJ, Hsu YH, Kiel DP, Karasik D) Bone 2012 May;50(5):1188-95 PMID: 22306695 PMCID: PMC3322322 SCOPUS ID: 2-s2.0-84859426283 02/07/2012 10 CitationsGenetic control of murine invariant natural killer T-cell development dynamically differs dependent on the examined tissue type. (Chen YG, Tsaih SW, Serreze DV) Genes Immun 2012 Feb;13(2):164-74 PMID: 21938016 PMCID: PMC3291802 SCOPUS ID: 2-s2.0-84857786403 09/23/2011 15 CitationsIntegration of QTL and bioinformatic tools to identify candidate genes for triglycerides in mice. (Leduc MS, Hageman RS, Verdugo RA, Tsaih SW, Walsh K, Churchill GA, Paigen B) J Lipid Res 2011 Sep;52(9):1672-82 PMID: 21622629 PMCID: PMC3151687 SCOPUS ID: 2-s2.0-80051824901 05/31/2011 21 CitationsGenetic analysis of mouse strains with variable serum sodium concentrations identifies the Nalcn sodium channel as a novel player in osmoregulation. (Sinke AP, Caputo C, Tsaih SW, Yuan R, Ren D, Deen PM, Korstanje R) Physiol Genomics 2011 Mar 16;43(5):265-70 PMID: 21177381 PMCID: PMC3068516 SCOPUS ID: 2-s2.0-79955745745 12/24/2010 28 CitationsUncovering genes and regulatory pathways related to urinary albumin excretion. (Hageman RS, Leduc MS, Caputo CR, Tsaih SW, Churchill GA, Korstanje R) J Am Soc Nephrol 2011 Jan;22(1):73-81 PMID: 21030601 PMCID: PMC3014036 SCOPUS ID: 2-s2.0-78651381769 10/30/2010 11 CitationsSequence variation at multiple loci influences red cell hemoglobin concentration. (Peters LL, Shavit JA, Lambert AJ, Tsaih SW, Li Q, Su Z, Leduc MS, Paigen B, Churchill GA, Ginsburg D, Brugnara C) Blood 2010 Dec 16;116(25):e139-49 PMID: 20833975 PMCID: PMC3031420 SCOPUS ID: 2-s2.0-78650486903 09/14/2010 10 CitationsComparison of unrestrained plethysmography and forced oscillation for identifying genetic variability of airway responsiveness in inbred mice. (Berndt A, Leme AS, Williams LK, Von Smith R, Savage HS, Stearns TM, Tsaih SW, Shapiro SD, Peters LL, Paigen B, Svenson KL) Physiol Genomics 2011 Jan 07;43(1):1-11 PMID: 20823217 PMCID: PMC3026348 SCOPUS ID: 2-s2.0-78651372560 09/09/2010 29 CitationsIdentification of genetic determinants of IGF-1 levels and longevity among mouse inbred strains. (Leduc MS, Hageman RS, Meng Q, Verdugo RA, Tsaih SW, Churchill GA, Paigen B, Yuan R) Aging Cell 2010 Oct;9(5):823-36 PMID: 20735370 PMCID: PMC3025299 SCOPUS ID: 2-s2.0-78349250620 08/26/2010 31 CitationsMouse BMD quantitative trait loci show improved concordance with human genome-wide association loci when recalculated on a new, common mouse genetic map. (Ackert-Bicknell CL, Karasik D, Li Q, Smith RV, Hsu YH, Churchill GA, Paigen BJ, Tsaih SW) J Bone Miner Res 2010 Aug;25(8):1808-20 PMID: 20200990 PMCID: PMC3153351 SCOPUS ID: 2-s2.0-77955720309 03/05/2010 42 CitationsA survey of airway responsiveness in 36 inbred mouse strains facilitates gene mapping studies and identification of quantitative trait loci. (Leme AS, Berndt A, Williams LK, Tsaih SW, Szatkiewicz JP, Verdugo R, Paigen B, Shapiro SD) Mol Genet Genomics 2010 Apr;283(4):317-26 PMID: 20143096 PMCID: PMC2885868 SCOPUS ID: 2-s2.0-77949909124 02/10/2010 30 CitationsAn experimental assessment of in silico haplotype association mapping in laboratory mice. (Burgess-Herbert SL, Tsaih SW, Stylianou IM, Walsh K, Cox AJ, Paigen B) BMC Genet 2009 Dec 09;10:81 PMID: 20003225 PMCID: PMC2797012 SCOPUS ID: 2-s2.0-73249149539 12/17/2009 20 CitationsGenetic analysis of albuminuria in aging mice and concordance with loci for human diabetic nephropathy found in a genome-wide association scan. (Tsaih SW, Pezzolesi MG, Yuan R, Warram JH, Krolewski AS, Korstanje R) Kidney Int 2010 Feb;77(3):201-10 PMID: 19924099 PMCID: PMC2807478 SCOPUS ID: 2-s2.0-74449084536 11/20/2009 37 CitationsHaplotype association mapping in mice. (Tsaih SW, Korstanje R) Methods Mol Biol 2009;573:213-22 PMID: 19763930 SCOPUS ID: 2-s2.0-73949149602 09/19/2009 17 CitationsGenetic analysis of blood pressure in 8 mouse intercross populations. (Feng M, Deerhake ME, Keating R, Thaisz J, Xu L, Tsaih SW, Smith R, Ishige T, Sugiyama F, Churchill GA, DiPetrillo K) Hypertension 2009 Oct;54(4):802-9 PMID: 19652078 PMCID: PMC2854560 SCOPUS ID: 2-s2.0-70349656061 08/05/2009 29 CitationsAging in inbred strains of mice: study design and interim report on median lifespans and circulating IGF1 levels. (Yuan R, Tsaih SW, Petkova SB, Marin de Evsikova C, Xing S, Marion MA, Bogue MA, Mills KD, Peters LL, Bult CJ, Rosen CJ, Sundberg JP, Harrison DE, Churchill GA, Paigen B) Aging Cell 2009 Jun;8(3):277-87 PMID: 19627267 PMCID: PMC2768517 SCOPUS ID: 2-s2.0-66149160389 07/25/2009 323 CitationsA new standard genetic map for the laboratory mouse. (Cox A, Ackert-Bicknell CL, Dumont BL, Ding Y, Bell JT, Brockmann GA, Wergedal JE, Bult C, Paigen B, Flint J, Tsaih SW, Churchill GA, Broman KW) Genetics 2009 Aug;182(4):1335-44 PMID: 19535546 PMCID: PMC2728870 SCOPUS ID: 2-s2.0-67349172256 06/19/2009 178 CitationsGenetic influence on electrocardiogram time intervals and heart rate in aging mice. (Xing S, Tsaih SW, Yuan R, Svenson KL, Jorgenson LM, So M, Paigen BJ, Korstanje R) Am J Physiol Heart Circ Physiol 2009 Jun;296(6):H1907-13 PMID: 19395551 PMCID: PMC2716104 SCOPUS ID: 2-s2.0-66949128310 04/28/2009 45 CitationsGenetic factors contributing to obesity and body weight can act through mechanisms affecting muscle weight, fat weight, or both. (Brockmann GA, Tsaih SW, Neuschl C, Churchill GA, Li R) Physiol Genomics 2009 Jan 08;36(2):114-26 PMID: 18984673 PMCID: PMC2636925 SCOPUS ID: 2-s2.0-58649110845 11/06/2008 19 CitationsPractical applications of the bioinformatics toolbox for narrowing quantitative trait loci. (Burgess-Herbert SL, Cox A, Tsaih SW, Paigen B) Genetics 2008 Dec;180(4):2227-35 PMID: 18845850 PMCID: PMC2600954 SCOPUS ID: 2-s2.0-61849106435 10/11/2008 50 CitationsIdd9/11 genetic locus regulates diabetogenic activity of CD4 T-cells in nonobese diabetic (NOD) mice. (Chen YG, Scheuplein F, Osborne MA, Tsaih SW, Chapman HD, Serreze DV) Diabetes 2008 Dec;57(12):3273-80 PMID: 18776136 PMCID: PMC2584133 SCOPUS ID: 2-s2.0-58149358856 09/09/2008 18 CitationsGenetic basis of HDL variation in 129/SvImJ and C57BL/6J mice: importance of testing candidate genes in targeted mutant mice. (Su Z, Wang X, Tsaih SW, Zhang A, Cox A, Sheehan S, Paigen B) J Lipid Res 2009 Jan;50(1):116-25 PMID: 18772481 PMCID: PMC2602865 SCOPUS ID: 2-s2.0-63449123597 09/06/2008 20 CitationsGenetic influence on immune phenotype revealed strain-specific variations in peripheral blood lineages. (Petkova SB, Yuan R, Tsaih SW, Schott W, Roopenian DC, Paigen B) Physiol Genomics 2008 Aug 15;34(3):304-14 PMID: 18544662 PMCID: PMC2519960 SCOPUS ID: 2-s2.0-50549096379 06/12/2008 55 CitationsQuantitative trait loci for urinary albumin in crosses between C57BL/6J and A/J inbred mice in the presence and absence of Apoe. (Doorenbos C, Tsaih SW, Sheehan S, Ishimori N, Navis G, Churchill G, Dipetrillo K, Korstanje R) Genetics 2008 May;179(1):693-9 PMID: 18493081 PMCID: PMC2390645 SCOPUS ID: 2-s2.0-52049121317 05/22/2008 15 CitationsCandidate genes for obesity revealed from a C57BL/6J x 129S1/SvImJ intercross. (Su Z, Korstanje R, Tsaih SW, Paigen B) Int J Obes (Lond) 2008 Jul;32(7):1180-9 PMID: 18414419 PMCID: PMC2782629 SCOPUS ID: 2-s2.0-47249116535 04/17/2008 27 CitationsCandidate genes for plasma triglyceride, FFA, and glucose revealed from an intercross between inbred mouse strains NZB/B1NJ and NZW/LacJ. (Su Z, Tsaih SW, Szatkiewicz J, Shen Y, Paigen B) J Lipid Res 2008 Jul;49(7):1500-10 PMID: 18362393 PMCID: PMC2431102 SCOPUS ID: 2-s2.0-50949088445 03/26/2008 18 CitationsGenetic analysis of albuminuria in a cross between C57BL/6J and DBA/2J mice. (Sheehan S, Tsaih SW, King BL, Stanton C, Churchill GA, Paigen B, DiPetrillo K) Am J Physiol Renal Physiol 2007 Nov;293(5):F1649-56 PMID: 17804484 SCOPUS ID: 2-s2.0-36049051389 09/07/2007 36 CitationsQuantitative trait loci associated with blood pressure of metabolic syndrome in the progeny of NZO/HILtJxC3H/HeJ intercrosses. (Nishihara E, Tsaih SW, Tsukahara C, Langley S, Sheehan S, DiPetrillo K, Kunita S, Yagami K, Churchill GA, Paigen B, Sugiyama F) Mamm Genome 2007 Aug;18(8):573-83 PMID: 17641813 SCOPUS ID: 2-s2.0-34848921734 07/21/2007 10 CitationsComplex genetic architecture revealed by analysis of high-density lipoprotein cholesterol in chromosome substitution strains and F2 crosses. (Stylianou IM, Tsaih SW, DiPetrillo K, Ishimori N, Li R, Paigen B, Churchill G) Genetics 2006 Oct;174(2):999-1007 PMID: 16951076 PMCID: PMC1602087 SCOPUS ID: 2-s2.0-33750478317 09/05/2006 28 CitationsFemur mechanical properties in the F2 progeny of an NZB/B1NJ x RF/J cross are regulated predominantly by genetic loci that regulate bone geometry. (Wergedal JE, Ackert-Bicknell CL, Tsaih SW, Sheng MH, Li R, Mohan S, Beamer WG, Churchill GA, Baylink DJ) J Bone Miner Res 2006 Aug;21(8):1256-66 PMID: 16869724 SCOPUS ID: 2-s2.0-33746401934 07/28/2006 30 CitationsStructural model analysis of multiple quantitative traits. (Li R, Tsaih SW, Shockley K, Stylianou IM, Wergedal J, Paigen B, Churchill GA) PLoS Genet 2006 Jul;2(7):e114 PMID: 16848643 PMCID: PMC1513264 SCOPUS ID: 2-s2.0-33746623411 07/20/2006 150 CitationsQuantitative trait mapping in a diallel cross of recombinant inbred lines. (Tsaih SW, Lu L, Airey DC, Williams RW, Churchill GA) Mamm Genome 2005 May;16(5):344-55 PMID: 16104382 SCOPUS ID: 2-s2.0-23844467156 08/18/2005 19 CitationsLead, diabetes, hypertension, and renal function: the normative aging study. (Tsaih SW, Korrick S, Schwartz J, Amarasiriwardena C, Aro A, Sparrow D, Hu H) Environ Health Perspect 2004 Aug;112(11):1178-82 PMID: 15289163 PMCID: PMC1247478 SCOPUS ID: 2-s2.0-4344686011 08/04/2004 138 CitationsDeterminants of bone and blood lead levels among minorities living in the Boston area. (Lin C, Kim R, Tsaih SW, Sparrow D, Hu H) Environ Health Perspect 2004 Aug;112(11):1147-51 PMID: 15289158 PMCID: PMC1247473 SCOPUS ID: 2-s2.0-4344571661 08/04/2004 33 CitationsAssociation between hemochromatosis genotype and lead exposure among elderly men: the normative aging study. (Wright RO, Silverman EK, Schwartz J, Tsaih SW, Senter J, Sparrow D, Weiss ST, Aro A, Hu H) Environ Health Perspect 2004 May;112(6):746-50 PMID: 15121519 PMCID: PMC1241970 SCOPUS ID: 2-s2.0-2442421209 05/04/2004 49 CitationsGenetic analysis of blood pressure in C3H/HeJ and SWR/J mice. (DiPetrillo K, Tsaih SW, Sheehan S, Johns C, Kelmenson P, Gavras H, Churchill GA, Paigen B) Physiol Genomics 2004 Apr 13;17(2):215-20 PMID: 14996992 SCOPUS ID: 2-s2.0-3843146548 03/05/2004 47 CitationsLead exposure biomarkers and mini-mental status exam scores in older men. (Wright RO, Tsaih SW, Schwartz J, Spiro A 3rd, McDonald K, Weiss ST, Hu H) Epidemiology 2003 Nov;14(6):713-8 PMID: 14569188 SCOPUS ID: 2-s2.0-1542787622 10/22/2003 90 CitationsApolipoprotein E genotype predicts 24-month bayley scales infant development score. (Wright RO, Hu H, Silverman EK, Tsaih SW, Schwartz J, Bellinger D, Palazuelos E, Weiss ST, Hernandez-Avila M) Pediatr Res 2003 Dec;54(6):819-25 PMID: 12930912 SCOPUS ID: 2-s2.0-0345276807 08/22/2003 127 CitationsAssociation between iron deficiency and blood lead level in a longitudinal analysis of children followed in an urban primary care clinic. (Wright RO, Tsaih SW, Schwartz J, Wright RJ, Hu H) J Pediatr 2003 Jan;142(1):9-14 PMID: 12520247 SCOPUS ID: 2-s2.0-0037238236 01/10/2003 156 CitationsCorrelates of bone and blood lead levels among middle-aged and elderly women. (Korrick SA, Schwartz J, Tsaih SW, Hunter DJ, Aro A, Rosner B, Speizer FE, Hu H) Am J Epidemiol 2002 Aug 15;156(4):335-43 PMID: 12181103 SCOPUS ID: 2-s2.0-0037103173 08/16/2002 64 CitationsOccupational determinants of bone and blood lead levels in middle aged and elderly men from the general community: the Normative Aging Study. (Elmarsafawy SF, Tsaih SW, Korrick S, Dickey JH, Sparrow D, Aro A, Hu H) Am J Ind Med 2002 Jul;42(1):38-49 PMID: 12111689 SCOPUS ID: 2-s2.0-0036306531 07/12/2002 15 CitationsMaternal bone lead as an independent risk factor for fetal neurotoxicity: a prospective study. (Gomaa A, Hu H, Bellinger D, Schwartz J, Tsaih SW, Gonzalez-Cossio T, Schnaas L, Peterson K, Aro A, Hernandez-Avila M) Pediatrics 2002 Jul;110(1 Pt 1):110-8 PMID: 12093955 SCOPUS ID: 2-s2.0-18444372934 07/03/2002 129 CitationsInfluence of bone resorption on the mobilization of lead from bone among middle-aged and elderly men: the Normative Aging Study. (Tsaih SW, Korrick S, Schwartz J, Lee ML, Amarasiriwardena C, Aro A, Sparrow D, Hu H) Environ Health Perspect 2001 Oct;109(10):995-9 PMID: 11675263 PMCID: PMC1242074 SCOPUS ID: 2-s2.0-0035197249 10/25/2001 56 CitationsThe independent contribution of bone and erythrocyte lead to urinary lead among middle-aged and elderly men: the normative aging study. (Tsaih SW, Schwartz J, Lee ML, Amarasiriwardena C, Aro A, Sparrow D, Hu H) Environ Health Perspect 1999 May;107(5):391-6 PMID: 10210695 PMCID: PMC1566410 SCOPUS ID: 2-s2.0-0032864185 04/22/1999 51 CitationsChildbearing and the risk of Hodgkin's disease. (Lambe M, Hsieh CC, Tsaih SW, Adami J, Glimelius B, Adami HO) Cancer Epidemiol Biomarkers Prev 1998 Sep;7(9):831-4 PMID: 9752994 SCOPUS ID: 2-s2.0-0031692411 09/30/1998 21 CitationsParity, age at first birth and the risk of carcinoma in situ of the breast. (Lambe M, Hsieh CC, Tsaih SW, Ekbom A, Trichopoulos D, Adami HO) Int J Cancer 1998 Jul 29;77(3):330-2 PMID: 9663590 SCOPUS ID: 2-s2.0-0031837420 07/15/1998 38 CitationsPregnancy and risk of non-Hodgkin's lymphoma: a prospective study. (Adami HO, Tsaih S, Lambe M, Hsieh C, Adami J, Trichopoulos D, Melbye M, Glimelius B) Int J Cancer 1997 Jan 17;70(2):155-8 PMID: 9009153 SCOPUS ID: 2-s2.0-0031018194 01/17/1997 45 CitationsMaternal risk of breast cancer following multiple births: a nationwide study in Sweden. (Lambe M, Hsieh C, Tsaih S, Ekbom A, Adami HO, Trichopoulos D) Cancer Causes Control 1996 Sep;7(5):533-8 PMID: 8877051 SCOPUS ID: 2-s2.0-0029817278 09/01/1996 44 Citations Last update: 10/11/2023