Medical College of Wisconsin
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Shuang Jia

Biostatistician III

Institution: Medical College of Wisconsin
Department: Pediatrics
Division: Pediatrics Endocrinology

Publications (42)

  • Monocytes in type 1 diabetes families exhibit high cytolytic activity and subset abundances that correlate with clinical progression. (Pant T, Lin CW, Bedrat A, Jia S, Roethle MF, Truchan NA, Ciecko AE, Chen YG, Hessner MJ) Sci Adv 2024 May 17;10(20):eadn2136 PMID: 38758799 PMCID: PMC11100571 SCOPUS ID: 2-s2.0-85193631768 05/17/2024       18 Citations
  • Dual-Stream Subspace Clustering Network for revealing gene targets in Alzheimer's disease. (Chen M, Jia S, Xue M, Huang H, Xu Z, Yang D, Zhu W, Song Q) Comput Biol Med 2022 Dec;151(Pt A):106305 PMID: 36401971 SCOPUS ID: 2-s2.0-85141918370 11/20/2022       12 Citations
  • Which Predictor, SctO2 or SstO2, Is more Sensitive for Postoperative Cognitive Dysfunction in Spine Surgery: A Prospective Observational Study? (Guo F, Jia S, Wang Q, Liu Q, Hu M, Wang W, Liu S, Li Q, Lu B, Zheng Y) Orthop Surg 2023 Jan;15(1):276-285 PMID: 36394155 PMCID: PMC9837245 SCOPUS ID: 2-s2.0-85142239332 11/18/2022       2 Citations
  • Scaffold-based three-dimensional cell model of pancreatic cancer is more suitable than scaffold-free three-dimensional cell model of pancreatic cancer for drug discovery. (Xie D, Jia S, Ping D, Wang D, Cao L) Cytotechnology 2022 Dec;74(6):657-667 PMID: 36389286 PMCID: PMC9652184 SCOPUS ID: 2-s2.0-85140239617 11/18/2022       5 Citations
  • Role of endoplasmic reticulum stress in impaired neonatal lung growth and bronchopulmonary dysplasia. (Pritchard KA Jr, Jing X, Teng M, Wells C, Jia S, Afolayan AJ, Jarzembowski J, Day BW, Naylor S, Hessner MJ, Konduri GG, Teng RJ) PLoS One 2022;17(8):e0269564 PMID: 36018859 PMCID: PMC9417039 SCOPUS ID: 2-s2.0-85137126858 08/27/2022       21 Citations
  • Probiotic normalization of systemic inflammation in siblings of type 1 diabetes patients: an open-label pilot study. (Cabrera SM, Coren AT, Pant T, Ciecko AE, Jia S, Roethle MF, Simpson PM, Atkinson SN, Salzman NH, Chen YG, Hessner MJ) Sci Rep 2022 Feb 28;12(1):3306 PMID: 35228584 PMCID: PMC8885673 SCOPUS ID: 2-s2.0-85125563972 03/02/2022       27 Citations
  • Lactobacillus plantarum 299v probiotic supplementation in men with stable coronary artery disease suppresses systemic inflammation. (Hofeld BC, Puppala VK, Tyagi S, Ahn KW, Anger A, Jia S, Salzman NH, Hessner MJ, Widlansky ME) Sci Rep 2021 Feb 17;11(1):3972 PMID: 33597583 PMCID: PMC7889883 SCOPUS ID: 2-s2.0-85101105180 02/19/2021       32 Citations
  • Cystic Fibrosis Plasma Blunts the Immune Response to Bacterial Infection. (Zhang X, Pan A, Jia S, Ideozu JE, Woods K, Murkowski K, Hessner MJ, Simpson PM, Levy H) Am J Respir Cell Mol Biol 2019 Sep;61(3):301-311 PMID: 30848661 PMCID: PMC6839930 SCOPUS ID: 2-s2.0-85071755620 03/09/2019       21 Citations
  • Identification of molecular signatures of cystic fibrosis disease status with plasma-based functional genomics. (Levy H, Jia S, Pan A, Zhang X, Kaldunski M, Nugent ML, Reske M, Feliciano RA, Quintero D, Renda MM, Woods KJ, Murkowski K, Johnson K, Verbsky J, Dasu T, Ideozu JE, McColley S, Quasney MW, Dahmer MK, Avner E, Farrell PM, Cannon CL, Jacob H, Simpson PM, Hessner MJ) Physiol Genomics 2019 Jan 01;51(1):27-41 PMID: 30540547 PMCID: PMC6383551 SCOPUS ID: 2-s2.0-85060056850 12/13/2018       16 Citations
  • A Serum-Induced Transcriptome and Serum Cytokine Signature Obtained at Diagnosis Correlates with the Development of Early Pancreatic Ductal Adenocarcinoma Metastasis. (Tsai S, McOlash L, Jia S, Zhang J, Simpson P, Kaldunski ML, Aldakkak M, Grewal J, Palen K, Dwinell MB, Johnson BD, Mackinnon A, Hessner MJ, Gershan JA) Cancer Epidemiol Biomarkers Prev 2019 Apr;28(4):680-689 PMID: 30530849 PMCID: PMC6545232 SCOPUS ID: 2-s2.0-85063867816 12/12/2018       2 Citations
  • Innate immune activity as a predictor of persistent insulin secretion and association with responsiveness to CTLA4-Ig treatment in recent-onset type 1 diabetes. (Cabrera SM, Engle S, Kaldunski M, Jia S, Geoffrey R, Simpson P, Szabo A, Speake C, Greenbaum CJ, Type 1 Diabetes TrialNet CTLA4-Ig (Abatacept) Study Group, Chen YG, Hessner MJ) Diabetologia 2018 Nov;61(11):2356-2370 PMID: 30167736 PMCID: PMC6182660 SCOPUS ID: 2-s2.0-85052798832 09/01/2018       32 Citations
  • Modulation of the diet and gastrointestinal microbiota normalizes systemic inflammation and β-cell chemokine expression associated with autoimmune diabetes susceptibility. (Henschel AM, Cabrera SM, Kaldunski ML, Jia S, Geoffrey R, Roethle MF, Lam V, Chen YG, Wang X, Salzman NH, Hessner MJ) PLoS One 2018;13(1):e0190351 PMID: 29293587 PMCID: PMC5749787 SCOPUS ID: 2-s2.0-85039965631 01/03/2018       25 Citations
  • Longitudinal analysis of hepatic transcriptome and serum metabolome demonstrates altered lipid metabolism following the onset of hyperglycemia in spontaneously diabetic biobreeding rats. (Regnell SE, Hessner MJ, Jia S, Åkesson L, Stenlund H, Moritz T, La Torre D, Lernmark Å) PLoS One 2017;12(2):e0171372 PMID: 28192442 PMCID: PMC5305198 SCOPUS ID: 2-s2.0-85012165803 02/14/2017       5 Citations
  • Investigation of coordination and order in transcription regulation of innate and adaptive immunity genes in type 1 diabetes. (Gao S, Wolanyk N, Chen Y, Jia S, Hessner MJ, Wang X) BMC Med Genomics 2017 Jan 31;10(1):7 PMID: 28143555 PMCID: PMC5282641 SCOPUS ID: 2-s2.0-85010777943 02/02/2017       8 Citations
  • The cohesin-associated protein Wapal is required for proper Polycomb-mediated gene silencing. (Stelloh C, Reimer MH, Pulakanti K, Blinka S, Peterson J, Pinello L, Jia S, Roumiantsev S, Hessner MJ, Milanovich S, Yuan GC, Rao S) Epigenetics Chromatin 2016;9:14 PMID: 27087855 PMCID: PMC4832553 SCOPUS ID: 2-s2.0-84963864324 04/19/2016       12 Citations
  • Alternatively Activated Macrophages Boost Induced Regulatory T and Th17 Cell Responses during Immunotherapy for Colitis. (Haribhai D, Ziegelbauer J, Jia S, Upchurch K, Yan K, Schmitt EG, Salzman NH, Simpson P, Hessner MJ, Chatila TA, Williams CB) J Immunol 2016 Apr 15;196(8):3305-17 PMID: 26927797 PMCID: PMC4851766 SCOPUS ID: 2-s2.0-84974839190 03/02/2016       43 Citations
  • Interleukin-1 antagonism moderates the inflammatory state associated with Type 1 diabetes during clinical trials conducted at disease onset. (Cabrera SM, Wang X, Chen YG, Jia S, Kaldunski ML, Greenbaum CJ, Type 1 Diabetes TrialNet Canakinumab Study Group, Mandrup-Poulsen T, AIDA Study Group, Hessner MJ) Eur J Immunol 2016 Apr;46(4):1030-46 PMID: 26692253 PMCID: PMC4828314 SCOPUS ID: 2-s2.0-84955291992 12/23/2015       52 Citations
  • Intermittent neonatal hypoxia elicits the upregulation of inflammatory-related genes in adult male rats through long-lasting programming effects. (Gehrand AL, Kaldunski ML, Bruder ED, Jia S, Hessner MJ, Raff H) Physiol Rep 2015 Dec;3(12) PMID: 26660555 PMCID: PMC4760434 SCOPUS ID: 2-s2.0-85006070875 12/15/2015       4 Citations
  • Plasma-induced signatures reveal an extracellular milieu possessing an immunoregulatory bias in treatment-naive paediatric inflammatory bowel disease. (Gurram B, Salzman NH, Kaldunski ML, Jia S, Li BU, Stephens M, Sood MR, Hessner MJ) Clin Exp Immunol 2016 Apr;184(1):36-49 PMID: 26660358 PMCID: PMC4778097 SCOPUS ID: 2-s2.0-84960311190 12/15/2015       17 Citations
  • Coagulation factor V mediates inhibition of tissue factor signaling by activated protein C in mice. (Liang HP, Kerschen EJ, Basu S, Hernandez I, Zogg M, Jia S, Hessner MJ, Toso R, Rezaie AR, Fernández JA, Camire RM, Ruf W, Griffin JH, Weiler H) Blood 2015 Nov 19;126(21):2415-23 PMID: 26341257 PMCID: PMC4653768 SCOPUS ID: 2-s2.0-84948989408 09/06/2015       36 Citations
  • EPCR-dependent PAR2 activation by the blood coagulation initiation complex regulates LPS-triggered interferon responses in mice. (Liang HP, Kerschen EJ, Hernandez I, Basu S, Zogg M, Botros F, Jia S, Hessner MJ, Griffin JH, Ruf W, Weiler H) Blood 2015 Apr 30;125(18):2845-54 PMID: 25733582 PMCID: PMC4424632 SCOPUS ID: 2-s2.0-84946801346 03/04/2015       75 Citations
  • Identification of a novel gene for diabetic traits in rats, mice, and humans. (Tsaih SW, Holl K, Jia S, Kaldunski M, Tschannen M, He H, Andrae JW, Li SH, Stoddard A, Wiederhold A, Parrington J, Ruas da Silva M, Galione A, Meigs J, Meta-Analyses of Glucose and Insulin-Related Traits Consortium (MAGIC) Investigators, Hoffmann RG, Simpson P, Jacob H, Hessner M, Solberg Woods LC) Genetics 2014 Sep;198(1):17-29 PMID: 25236446 PMCID: PMC4174929 SCOPUS ID: 2-s2.0-84907982004 09/23/2014       41 Citations
  • Molecular signatures differentiate immune states in type 1 diabetic families. (Chen YG, Cabrera SM, Jia S, Kaldunski ML, Kramer J, Cheong S, Geoffrey R, Roethle MF, Woodliff JE, Greenbaum CJ, Wang X, Hessner MJ) Diabetes 2014 Nov;63(11):3960-73 PMID: 24760139 PMCID: PMC4207392 SCOPUS ID: 2-s2.0-84906086651 04/25/2014       64 Citations
  • Temporal induction of immunoregulatory processes coincides with age-dependent resistance to viral-induced type 1 diabetes. (Chen YG, Mordes JP, Blankenhorn EP, Kashmiri H, Kaldunski ML, Jia S, Geoffrey R, Wang X, Hessner MJ) Genes Immun 2013 Sep;14(6):387-400 PMID: 23739610 PMCID: PMC4027975 SCOPUS ID: 2-s2.0-84883880468 06/07/2013       12 Citations
  • IL-10 produced by induced regulatory T cells (iTregs) controls colitis and pathogenic ex-iTregs during immunotherapy. (Schmitt EG, Haribhai D, Williams JB, Aggarwal P, Jia S, Charbonnier LM, Yan K, Lorier R, Turner A, Ziegelbauer J, Georgiev P, Simpson P, Salzman NH, Hessner MJ, Broeckel U, Chatila TA, Williams CB) J Immunol 2012 Dec 15;189(12):5638-48 PMID: 23125413 PMCID: PMC3537488 SCOPUS ID: 2-s2.0-84871173673 11/06/2012       78 Citations
  • Biobreeding rat islets exhibit reduced antioxidative defense and N-acetyl cysteine treatment delays type 1 diabetes. (Bogdani M, Henschel AM, Kansra S, Fuller JM, Geoffrey R, Jia S, Kaldunski ML, Pavletich S, Prosser S, Chen YG, Lernmark A, Hessner MJ) J Endocrinol 2013 Feb;216(2):111-23 PMID: 23111281 PMCID: PMC4077722 SCOPUS ID: 2-s2.0-84874778734 11/01/2012       26 Citations
  • Transcriptional signatures as a disease-specific and predictive inflammatory biomarker for type 1 diabetes. (Levy H, Wang X, Kaldunski M, Jia S, Kramer J, Pavletich SJ, Reske M, Gessel T, Yassai M, Quasney MW, Dahmer MK, Gorski J, Hessner MJ) Genes Immun 2012 Dec;13(8):593-604 PMID: 22972474 PMCID: PMC4265236 SCOPUS ID: 2-s2.0-84870911405 09/14/2012       62 Citations
  • Predicting disease-related subnetworks for type 1 diabetes using a new network activity score. (Gao S, Jia S, Hessner MJ, Wang X) OMICS 2012 Oct;16(10):566-78 PMID: 22917479 PMCID: PMC3459426 SCOPUS ID: 2-s2.0-84867092043 08/25/2012       10 Citations
  • Requirements for growth and IL-10 expression of highly purified human T regulatory cells. (Bonacci B, Edwards B, Jia S, Williams CB, Hessner MJ, Gauld SB, Verbsky JW) J Clin Immunol 2012 Oct;32(5):1118-28 PMID: 22562448 PMCID: PMC4271826 SCOPUS ID: 2-s2.0-84866736118 05/09/2012       12 Citations
  • A requisite role for induced regulatory T cells in tolerance based on expanding antigen receptor diversity. (Haribhai D, Williams JB, Jia S, Nickerson D, Schmitt EG, Edwards B, Ziegelbauer J, Yassai M, Li SH, Relland LM, Wise PM, Chen A, Zheng YQ, Simpson PM, Gorski J, Salzman NH, Hessner MJ, Chatila TA, Williams CB) Immunity 2011 Jul 22;35(1):109-22 PMID: 21723159 PMCID: PMC3295638 SCOPUS ID: 2-s2.0-79960453738 07/05/2011       377 Citations
  • Use of transcriptional signatures induced in lymphoid and myeloid cell lines as an inflammatory biomarker in Type 1 diabetes. (Jia S, Kaldunski M, Jailwala P, Geoffrey R, Kramer J, Wang X, Hessner MJ) Physiol Genomics 2011 Jun 15;43(11):697-709 PMID: 21406607 PMCID: PMC3121160 SCOPUS ID: 2-s2.0-79959300845 03/17/2011       13 Citations
  • Activated protein C targets CD8+ dendritic cells to reduce the mortality of endotoxemia in mice. (Kerschen E, Hernandez I, Zogg M, Jia S, Hessner MJ, Fernandez JA, Griffin JH, Huettner CS, Castellino FJ, Weiler H) J Clin Invest 2010 Sep;120(9):3167-78 PMID: 20714108 PMCID: PMC2929901 SCOPUS ID: 2-s2.0-77956372381 08/18/2010       86 Citations
  • Identification of a serum-induced transcriptional signature associated with type 1 diabetes in the BioBreeding rat. (Kaldunski M, Jia S, Geoffrey R, Basken J, Prosser S, Kansra S, Mordes JP, Lernmark A, Wang X, Hessner MJ) Diabetes 2010 Oct;59(10):2375-85 PMID: 20682698 PMCID: PMC3279523 SCOPUS ID: 2-s2.0-77957549892 08/05/2010       27 Citations
  • An autoinflammatory disease due to homozygous deletion of the IL1RN locus. (Reddy S, Jia S, Geoffrey R, Lorier R, Suchi M, Broeckel U, Hessner MJ, Verbsky J) N Engl J Med 2009 Jun 04;360(23):2438-44 PMID: 19494219 PMCID: PMC2803085 SCOPUS ID: 2-s2.0-66649113371 06/06/2009       378 Citations
  • Identification of a molecular signature in human type 1 diabetes mellitus using serum and functional genomics. (Wang X, Jia S, Geoffrey R, Alemzadeh R, Ghosh S, Hessner MJ) J Immunol 2008 Feb 01;180(3):1929-37 PMID: 18209091 SCOPUS ID: 2-s2.0-40749100302 01/23/2008       100 Citations
  • Quantitative measurement of pathogen-specific human memory T cell repertoire diversity using a CDR3 beta-specific microarray. (Wang X, Jia S, Meyer L, Yassai MB, Naumov YN, Gorski J, Hessner MJ) BMC Genomics 2007 Sep 19;8:329 PMID: 17880719 PMCID: PMC2039751 SCOPUS ID: 2-s2.0-35448956566 09/21/2007       5 Citations
  • Acquisition of accurate gene expression information from microarray measurements (Jia S, Gao S, Hessner MJ, Wang X) Current Topics in Human Genetics Studies in Complex Diseases 1 January 2007:351-364 SCOPUS ID: 2-s2.0-84967662813 01/01/2007    
  • Evidence of a functional role for mast cells in the development of type 1 diabetes mellitus in the BioBreeding rat. (Geoffrey R, Jia S, Kwitek AE, Woodliff J, Ghosh S, Lernmark A, Wang X, Hessner MJ) J Immunol 2006 Nov 15;177(10):7275-86 PMID: 17082646 SCOPUS ID: 2-s2.0-33750840512 11/04/2006       66 Citations
  • Comprehensive quality control utilizing the prehybridization third-dye image leads to accurate gene expression measurements by cDNA microarrays. (Wang X, Jia S, Meyer L, Xiang B, Chen LY, Jiang N, Moreno C, Jacob HJ, Ghosh S, Hessner MJ) BMC Bioinformatics 2006 Aug 14;7:378 PMID: 16907976 PMCID: PMC1563483 SCOPUS ID: 2-s2.0-33748657365 08/16/2006       9 Citations
  • Three-color cDNA microarrays with prehybridization quality control yield gene expression data comparable to that of commercial platforms. (Hessner MJ, Xiang B, Jia S, Geoffrey R, Holmes S, Meyer L, Muheisen S, Wang X) Physiol Genomics 2006 Mar 13;25(1):166-78 PMID: 16403843 SCOPUS ID: 2-s2.0-33645766760 01/13/2006       6 Citations
  • Parallel algorithm in microarray data processing (Wang X, Jia S, Zhou G, Hessner MJ) Proceedings of the International Conference on Parallel and Distributed Processing Techniques and Applications PDPTA 04 2004;1:43-48 SCOPUS ID: 2-s2.0-12344288686 12/01/2004    
  • Involvement of eotaxin, eosinophils, and pancreatic predisposition in development of type 1 diabetes mellitus in the BioBreeding rat. (Hessner MJ, Wang X, Meyer L, Geoffrey R, Jia S, Fuller J, Lernmark A, Ghosh S) J Immunol 2004 Dec 01;173(11):6993-7002 PMID: 15557196 SCOPUS ID: 2-s2.0-9144238154 11/24/2004       53 Citations
    • Last update: 03/10/2025