Medical College of Wisconsin
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Tina C. Wan PhD

Research Scientist II

Institution: Medical College of Wisconsin
Department: Pediatrics
Division: Cardiology

Publications (35)

  • Extrahelical Binding Site for a 1H-Imidazo[4,5-c]quinolin-4-amine A3 Adenosine Receptor Positive Allosteric Modulator on Helix 8 and Distal Portions of Transmembrane Domains 1 and 7. (Fisher CL, Pavan M, Salmaso V, Keyes RF, Wan TC, Pradhan B, Gao ZG, Smith BC, Jacobson KA, Auchampach JA) Mol Pharmacol 2024 Feb 15;105(3):213-223 PMID: 38182432 PMCID: PMC10877738 SCOPUS ID: 2-s2.0-85185222449 01/06/2024       1 Citation
  • First Potent Macrocyclic A3 Adenosine Receptor Agonists Reveal G-Protein and β-Arrestin2 Signaling Preferences. (Tosh DK, Fisher CL, Salmaso V, Wan TC, Campbell RG, Chen E, Gao ZG, Auchampach JA, Jacobson KA) ACS Pharmacol Transl Sci 2023 Sep 08;6(9):1288-1305 PMID: 37705595 PMCID: PMC10496144 SCOPUS ID: 2-s2.0-85168520378 09/14/2023    
  • Pharmacological inhibition of the acetyltransferase Tip60 mitigates myocardial infarction injury. (Wang X, Wan TC, Kulik KR, Lauth A, Smith BC, Lough JW, Auchampach JA) Dis Model Mech 2023 May 01;16(5) PMID: 36341679 PMCID: PMC9672930 SCOPUS ID: 2-s2.0-85141362492 11/08/2022       4 Citations
  • Characterization of Dual-Acting A3 Adenosine Receptor Positive Allosteric Modulators That Preferentially Enhance Adenosine-Induced Gαi3 and GαoA Isoprotein Activation. (Fisher CL, Fallot LB, Wan TC, Keyes RF, Suresh RR, Rothwell AC, Gao ZG, McCorvy JD, Smith BC, Jacobson KA, Auchampach JA) ACS Pharmacol Transl Sci 2022 Aug 12;5(8):625-641 PMID: 35983277 PMCID: PMC9380209 SCOPUS ID: 2-s2.0-85135593508 08/20/2022       7 Citations
  • Conditional depletion of the acetyltransferase Tip60 protects against the damaging effects of myocardial infarction. (Wang X, Wan TC, Lauth A, Purdy AL, Kulik KR, Patterson M, Lough JW, Auchampach JA) J Mol Cell Cardiol 2022 Feb;163:9-19 PMID: 34610340 PMCID: PMC8816866 SCOPUS ID: 2-s2.0-85116932867 10/06/2021       6 Citations
  • Evidence that the acetyltransferase Tip60 induces the DNA damage response and cell-cycle arrest in neonatal cardiomyocytes. (Wang X, Lupton C, Lauth A, Wan TC, Foster P, Patterson M, Auchampach JA, Lough JW) J Mol Cell Cardiol 2021 Jun;155:88-98 PMID: 33609538 PMCID: PMC8154663 SCOPUS ID: 2-s2.0-85102458794 02/21/2021       7 Citations
  • Myh6-driven Cre recombinase activates the DNA damage response and the cell cycle in the myocardium in the absence of loxP sites. (Wang X, Lauth A, Wan TC, Lough JW, Auchampach JA) Dis Model Mech 2020 Dec 18;13(12) PMID: 33106234 PMCID: PMC7758623 SCOPUS ID: 2-s2.0-85098138727 10/28/2020       13 Citations
  • Llgl1 regulates zebrafish cardiac development by mediating Yap stability in cardiomyocytes. (Flinn MA, Otten C, Brandt ZJ, Bostrom JR, Kenarsary A, Wan TC, Auchampach JA, Abdelilah-Seyfried S, O'Meara CC, Link BA) Development 2020 Aug 25;147(16) PMID: 32843528 PMCID: PMC7473637 SCOPUS ID: 2-s2.0-85089923843 08/28/2020       7 Citations
  • Ability of CP-532,903 to protect mouse hearts from ischemia/reperfusion injury is dependent on expression of A3 adenosine receptors in cardiomyoyctes. (Wan TC, Tampo A, Kwok WM, Auchampach JA) Biochem Pharmacol 2019 May;163:21-31 PMID: 30710517 PMCID: PMC6470012 SCOPUS ID: 2-s2.0-85061006338 02/03/2019       9 Citations
  • IL-13 promotes in vivo neonatal cardiomyocyte cell cycle activity and heart regeneration. (Wodsedalek DJ, Paddock SJ, Wan TC, Auchampach JA, Kenarsary A, Tsaih SW, Flister MJ, O'Meara CC) Am J Physiol Heart Circ Physiol 2019 Jan 01;316(1):H24-H34 PMID: 30339498 SCOPUS ID: 2-s2.0-85060194313 10/20/2018       32 Citations
  • Species differences and mechanism of action of A3 adenosine receptor allosteric modulators. (Du L, Gao ZG, Paoletta S, Wan TC, Gizewski ET, Barbour S, van Veldhoven JPD, IJzerman AP, Jacobson KA, Auchampach JA) Purinergic Signal 2018 Mar;14(1):59-71 PMID: 29170977 PMCID: PMC5842153 SCOPUS ID: 2-s2.0-85034734757 11/25/2017       16 Citations
  • Hypothermia in mouse is caused by adenosine A1 and A3 receptor agonists and AMP via three distinct mechanisms. (Carlin JL, Jain S, Gizewski E, Wan TC, Tosh DK, Xiao C, Auchampach JA, Jacobson KA, Gavrilova O, Reitman ML) Neuropharmacology 2017 Mar 01;114:101-113 PMID: 27914963 PMCID: PMC5183552 SCOPUS ID: 2-s2.0-85002410442 12/05/2016       53 Citations
  • Characterization of Dahl salt-sensitive rats with genetic disruption of the A2B adenosine receptor gene: implications for A2B adenosine receptor signaling during hypertension. (Nayak S, Khan MA, Wan TC, Pei H, Linden J, Dwinell MR, Geurts AM, Imig JD, Auchampach JA) Purinergic Signal 2015 Dec;11(4):519-31 PMID: 26385692 PMCID: PMC4648794 SCOPUS ID: 2-s2.0-84947616348 09/20/2015       9 Citations
  • Effect of human 15-lipoxygenase-1 metabolites on vascular function in mouse mesenteric arteries and hearts. (Kriska T, Cepura C, Siangjong L, Wan TC, Auchampach JA, Shaish A, Haratz D, Kumar G, Falck JR, Gauthier KM, Campbell WB) Prostaglandins Other Lipid Mediat 2013 Oct;106:8-15 PMID: 23872364 PMCID: PMC3844054 SCOPUS ID: 2-s2.0-84883361018 07/23/2013       7 Citations
  • Adenosine A1 receptors heterodimerize with β1- and β2-adrenergic receptors creating novel receptor complexes with altered G protein coupling and signaling. (Chandrasekera PC, Wan TC, Gizewski ET, Auchampach JA, Lasley RD) Cell Signal 2013 Apr;25(4):736-42 PMID: 23291003 PMCID: PMC3896953 SCOPUS ID: 2-s2.0-84873252073 01/08/2013       34 Citations
  • Structure-guided design of A(3) adenosine receptor-selective nucleosides: combination of 2-arylethynyl and bicyclo[3.1.0]hexane substitutions. (Tosh DK, Deflorian F, Phan K, Gao ZG, Wan TC, Gizewski E, Auchampach JA, Jacobson KA) J Med Chem 2012 May 24;55(10):4847-60 PMID: 22559880 PMCID: PMC3371665 SCOPUS ID: 2-s2.0-84861499550 05/09/2012       75 Citations
  • Polyamidoamine (PAMAM) dendrimer conjugate specifically activates the A3 adenosine receptor to improve post-ischemic/reperfusion function in isolated mouse hearts. (Wan TC, Tosh DK, Du L, Gizewski ET, Jacobson KA, Auchampach JA) BMC Pharmacol 2011 Oct 31;11:11 PMID: 22039965 PMCID: PMC3247180 SCOPUS ID: 2-s2.0-80055018439 11/02/2011       25 Citations
  • A role for the low-affinity A2B adenosine receptor in regulating superoxide generation by murine neutrophils. (van der Hoeven D, Wan TC, Gizewski ET, Kreckler LM, Maas JE, Van Orman J, Ravid K, Auchampach JA) J Pharmacol Exp Ther 2011 Sep;338(3):1004-12 PMID: 21693629 PMCID: PMC3164346 SCOPUS ID: 2-s2.0-80052168465 06/23/2011       45 Citations
  • Are we putting too much stock in mice? (Auchampach JA, Maas JE, Wan TC, Figler RA, Gross GJ) J Mol Cell Cardiol 2011 Mar;50(3):584-5 PMID: 21129379 SCOPUS ID: 2-s2.0-79551593927 12/07/2010    
  • Evidence that the acute phase of ischemic preconditioning does not require signaling by the A 2B adenosine receptor. (Maas JE, Wan TC, Figler RA, Gross GJ, Auchampach JA) J Mol Cell Cardiol 2010 Nov;49(5):886-93 PMID: 20797398 PMCID: PMC2958103 SCOPUS ID: 2-s2.0-77957236611 08/28/2010       31 Citations
  • A(3) adenosine receptor activation during reperfusion reduces infarct size through actions on bone marrow-derived cells. (Ge ZD, van der Hoeven D, Maas JE, Wan TC, Auchampach JA) J Mol Cell Cardiol 2010 Aug;49(2):280-6 PMID: 20132822 PMCID: PMC2885516 SCOPUS ID: 2-s2.0-77953713842 02/06/2010       42 Citations
  • Synthesis and pharmacological characterization of [(125)I]MRS5127, a high affinity, selective agonist radioligand for the A3 adenosine receptor. (Auchampach JA, Gizewski ET, Wan TC, de Castro S, Brown GG Jr, Jacobson KA) Biochem Pharmacol 2010 Apr 01;79(7):967-73 PMID: 19917269 PMCID: PMC2815200 SCOPUS ID: 2-s2.0-77449155693 11/18/2009       21 Citations
  • Adenosine suppresses lipopolysaccharide-induced tumor necrosis factor-alpha production by murine macrophages through a protein kinase A- and exchange protein activated by cAMP-independent signaling pathway. (Kreckler LM, Gizewski E, Wan TC, Auchampach JA) J Pharmacol Exp Ther 2009 Dec;331(3):1051-61 PMID: 19749080 PMCID: PMC2784717 SCOPUS ID: 2-s2.0-73349106518 09/15/2009       37 Citations
  • Characterization of the A2B adenosine receptor from mouse, rabbit, and dog. (Auchampach JA, Kreckler LM, Wan TC, Maas JE, van der Hoeven D, Gizewski E, Narayanan J, Maas GE) J Pharmacol Exp Ther 2009 Apr;329(1):2-13 PMID: 19141710 PMCID: PMC2670590 SCOPUS ID: 2-s2.0-63849116251 01/15/2009       35 Citations
  • Activation of the A(3) adenosine receptor suppresses superoxide production and chemotaxis of mouse bone marrow neutrophils. (van der Hoeven D, Wan TC, Auchampach JA) Mol Pharmacol 2008 Sep;74(3):685-96 PMID: 18583455 PMCID: PMC2574951 SCOPUS ID: 2-s2.0-50449094182 06/28/2008       71 Citations
  • Design of (N)-methanocarba adenosine 5'-uronamides as species-independent A3 receptor-selective agonists. (Melman A, Gao ZG, Kumar D, Wan TC, Gizewski E, Auchampach JA, Jacobson KA) Bioorg Med Chem Lett 2008 May 01;18(9):2813-9 PMID: 18424135 PMCID: PMC2430186 SCOPUS ID: 2-s2.0-42949156868 04/22/2008       43 Citations
  • The A3 adenosine receptor agonist CP-532,903 [N6-(2,5-dichlorobenzyl)-3'-aminoadenosine-5'-N-methylcarboxamide] protects against myocardial ischemia/reperfusion injury via the sarcolemmal ATP-sensitive potassium channel. (Wan TC, Ge ZD, Tampo A, Mio Y, Bienengraeber MW, Tracey WR, Gross GJ, Kwok WM, Auchampach JA) J Pharmacol Exp Ther 2008 Jan;324(1):234-43 PMID: 17906066 PMCID: PMC2435594 SCOPUS ID: 2-s2.0-37349025060 10/02/2007       69 Citations
  • Cl-IB-MECA [2-chloro-N6-(3-iodobenzyl)adenosine-5'-N-methylcarboxamide] reduces ischemia/reperfusion injury in mice by activating the A3 adenosine receptor. (Ge ZD, Peart JN, Kreckler LM, Wan TC, Jacobson MA, Gross GJ, Auchampach JA) J Pharmacol Exp Ther 2006 Dec;319(3):1200-10 PMID: 16985166 SCOPUS ID: 2-s2.0-33751189857 09/21/2006       86 Citations
  • Adenosine inhibits tumor necrosis factor-alpha release from mouse peritoneal macrophages via A2A and A2B but not the A3 adenosine receptor. (Kreckler LM, Wan TC, Ge ZD, Auchampach JA) J Pharmacol Exp Ther 2006 Apr;317(1):172-80 PMID: 16339914 SCOPUS ID: 2-s2.0-33645115158 12/13/2005       168 Citations
  • Comparison of three different A1 adenosine receptor antagonists on infarct size and multiple cycle ischemic preconditioning in anesthetized dogs. (Auchampach JA, Jin X, Moore J, Wan TC, Kreckler LM, Ge ZD, Narayanan J, Whalley E, Kiesman W, Ticho B, Smits G, Gross GJ) J Pharmacol Exp Ther 2004 Mar;308(3):846-56 PMID: 14634049 SCOPUS ID: 2-s2.0-10744233575 11/25/2003       43 Citations
  • Decreased PMCA4b expression has no effect on calcium homeostasis in Meg-01 cells. (Wan TC, Dean WL) Platelets 2003 Aug;14(5):295-303 PMID: 12944246 SCOPUS ID: 2-s2.0-0141678865 08/29/2003       3 Citations
  • A3 adenosine receptor agonist IB-MECA reduces myocardial ischemia-reperfusion injury in dogs. (Auchampach JA, Ge ZD, Wan TC, Moore J, Gross GJ) Am J Physiol Heart Circ Physiol 2003 Aug;285(2):H607-13 PMID: 12689858 PMCID: PMC3860822 SCOPUS ID: 2-s2.0-0037962234 04/12/2003       68 Citations
  • Plasma membrane Ca2+-ATPase isoform 4b is phosphorylated on tyrosine 1176 in activated human platelets. (Wan TC, Zabe M, Dean WL) Thromb Haemost 2003 Jan;89(1):122-31 PMID: 12540962 SCOPUS ID: 2-s2.0-0037251697 01/24/2003       30 Citations
  • Induction of immune responses to ovarian tumor antigens by multiparity. (Shields LB, Gerçel-Taylor C, Yashar CM, Wan TC, Katsanis WA, Spinnato JA, Taylor DD) J Soc Gynecol Investig 1997;4(6):298-304 PMID: 9408885 SCOPUS ID: 2-s2.0-0342437099 12/31/1997       66 Citations
  • Canine mast cell adenosine receptors: cloning and expression of the A3 receptor and evidence that degranulation is mediated by the A2B receptor. (Auchampach JA, Jin X, Wan TC, Caughey GH, Linden J) Mol Pharmacol 1997 Nov;52(5):846-60 PMID: 9351976 SCOPUS ID: 2-s2.0-0030817408 11/14/1997       174 Citations
    • Last update: 01/10/2024