Medical College of Wisconsin
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Vanessa Leone PhD

Vanessa Leone PhD profile photo picture

Assistant Professor

Institution: Medical College of Wisconsin
Department: Biophysics

image of /images/ORCIDiD_icon16x16.png   https://orcid.org/0000-0001-7017-4020

Member of the Cancer Center
Member of the Data Science Institute


I am willing to collaborate on research projects.

View Curriculum Vitae

Publications (21)

  • Structural transport and inhibition mechanism of the mitochondrial pyruvate carrier. (Lacabanne D, Ruprecht JJ, Sichrovsky M, Forrest LR, Leone V, Tavoulari S, Kunji ERS) Trends Biochem Sci 2026 Feb;51(2):142-157 PMID: 41353022 SCOPUS ID: 2-s2.0-105024324581 12/07/2025       1 Citation
  • From snapshots to ensembles: Integrating experimental data and dynamics (Leone V, Marinelli F) Current Opinion in Structural Biology December 2025;95 SCOPUS ID: 2-s2.0-105015421270 12/01/2025       4 Citations
  • A new class of binding-protein dependent solute transporter exemplified by the TAXI-GltS system from Bordetella pertussis. (Jaques LM, Davies JFS, Sheldon-Towler JJ, Kelly DJ, Leone V, Mulligan C) Commun Biol 2025 Aug 12;8(1):1201 PMID: 40797014 PMCID: PMC12344293 SCOPUS ID: 2-s2.0-105013272218 08/13/2025       1 Citation
  • Molecular basis of pyruvate transport and inhibition of the human mitochondrial pyruvate carrier. (Sichrovsky M, Lacabanne D, Ruprecht JJ, Rana JJ, Stanik K, Dionysopoulou M, Sowton AP, King MS, Jones SA, Cooper L, Hardwick SW, Paris G, Chirgadze DY, Ding S, Fearnley IM, Palmer SM, Pardon E, Steyaert J, Leone V, Forrest LR, Tavoulari S, Kunji ERS) Sci Adv 2025 Apr 18;11(16):eadw1489 PMID: 40249800 PMCID: PMC12007569 SCOPUS ID: 2-s2.0-105003302158 04/18/2025       8 Citations
  • PLUMED Tutorials: A collaborative, community-driven learning ecosystem. (Tribello GA, Bonomi M, Bussi G, Camilloni C, Armstrong BI, Arsiccio A, Aureli S, Ballabio F, Bernetti M, Bonati L, Brookes SGH, Brotzakis ZF, Capelli R, Ceriotti M, Chan KT, Cossio P, Dasetty S, Donadio D, Ensing B, Ferguson AL, Fraux G, Gale JD, Gervasio FL, Giorgino T, Herringer NSM, Hocky GM, Hoff SE, Invernizzi M, Languin-Cattoën O, Leone V, Limongelli V, Lopez-Acevedo O, Marinelli F, Febrer Martinez P, Masetti M, Mehdi S, Michaelides A, Murtada MH, Parrinello M, Piaggi PM, Pietropaolo A, Pietrucci F, Pipolo S, Pritchard C, Raiteri P, Raniolo S, Rapetti D, Rizzi V, Rydzewski J, Salvalaglio M, Schran C, Seal A, Shayesteh Zadeh A, Silva TFD, Spiwok V, Stirnemann G, Sucerquia D, Tiwary P, Valsson O, Vendruscolo M, Voth GA, White AD, Wu J) J Chem Phys 2025 Mar 07;162(9) PMID: 40035582 PMCID: PMC12317779 SCOPUS ID: 2-s2.0-86000483661 03/04/2025       19 Citations
  • Insights into autoregulation of a membrane protein complex by its cytoplasmic domains. (Leone V, Bradshaw RT, Koshy C, Lee PS, Fenollar-Ferrer C, Heinz V, Ziegler C, Forrest LR) Biophys J 2023 Feb 07;122(3):577-594 PMID: 36528790 PMCID: PMC9941749 SCOPUS ID: 2-s2.0-85145984239 12/19/2022       1 Citation
  • Chloride-dependent conformational changes in the GlyT1 glycine transporter. (Zhang YW, Uchendu S, Leone V, Bradshaw RT, Sangwa N, Forrest LR, Rudnick G) Proc Natl Acad Sci U S A 2021 Mar 09;118(10) PMID: 33658361 PMCID: PMC7958241 SCOPUS ID: 2-s2.0-85102461090 03/05/2021       24 Citations
  • Interpretation of spectroscopic data using molecular simulations for the secondary active transporter BetP. (Leone V, Waclawska I, Kossmann K, Koshy C, Sharma M, Prisner TF, Ziegler C, Endeward B, Forrest LR) J Gen Physiol 2019 Mar 04;151(3):381-394 PMID: 30728216 PMCID: PMC6400524 SCOPUS ID: 2-s2.0-85062413313 02/08/2019       9 Citations
  • Structure and mechanism of the ATP synthase membrane motor inferred from quantitative integrative modeling. (Leone V, Faraldo-Gómez JD) J Gen Physiol 2016 Dec;148(6):441-457 PMID: 27821609 PMCID: PMC5129741 SCOPUS ID: 2-s2.0-85008474337 11/09/2016       20 Citations
  • Predicted Structures of the Proton-Bound Membrane-Embedded Rotor Rings of the Saccharomyces cerevisiae and Escherichia coli ATP Synthases. (Zhou W, Leone V, Krah A, Faraldo-Gómez JD) J Phys Chem B 2017 Apr 20;121(15):3297-3307 PMID: 27715045 PMCID: PMC5593136 SCOPUS ID: 2-s2.0-85020184139 11/04/2016       7 Citations
  • On the principle of ion selectivity in Na+/H+-coupled membrane proteins: experimental and theoretical studies of an ATP synthase rotor. (Leone V, Pogoryelov D, Meier T, Faraldo-Gómez JD) Proc Natl Acad Sci U S A 2015 Mar 10;112(10):E1057-66 PMID: 25713346 PMCID: PMC4364180 SCOPUS ID: 2-s2.0-84924401794 02/26/2015       34 Citations
  • HIV-1 integrase binding to its cellular partners: a perspective from computational biology. (Quy VC, Carnevale V, Manganaro L, Lusic M, Rossetti G, Leone V, Fenollar-Ferrer C, Raugei S, Del Sal G, Giacca M, Carloni P) Curr Pharm Des 2014;20(21):3412-21 PMID: 24001231 SCOPUS ID: 2-s2.0-84903727821 09/05/2013       2 Citations
  • A new type of Na(+)-driven ATP synthase membrane rotor with a two-carboxylate ion-coupling motif. (Schulz S, Iglesias-Cans M, Krah A, Yildiz O, Leone V, Matthies D, Cook GM, Faraldo-Gómez JD, Meier T) PLoS Biol 2013;11(6):e1001596 PMID: 23824040 PMCID: PMC3692424 SCOPUS ID: 2-s2.0-84879380817 07/05/2013       49 Citations
  • Molecular description of the propagation of chirality from molecules to complex systems: different mechanisms controlled by hydrophobic interactions. (Marinelli F, Sorrenti A, Corvaglia V, Leone V, Mancini G) Chemistry 2012 Nov 12;18(46):14680-8 PMID: 23019089 SCOPUS ID: 2-s2.0-84868688876 09/29/2012       21 Citations
  • A c subunit with four transmembrane helices and one ion (Na+)-binding site in an archaeal ATP synthase: implications for c ring function and structure. (Mayer F, Leone V, Langer JD, Faraldo-Gómez JD, Müller V) J Biol Chem 2012 Nov 16;287(47):39327-37 PMID: 23007388 PMCID: PMC3501044 SCOPUS ID: 2-s2.0-84869234427 09/26/2012       22 Citations
  • Engineering rotor ring stoichiometries in the ATP synthase. (Pogoryelov D, Klyszejko AL, Krasnoselska GO, Heller EM, Leone V, Langer JD, Vonck J, Müller DJ, Faraldo-Gómez JD, Meier T) Proc Natl Acad Sci U S A 2012 Jun 19;109(25):E1599-608 PMID: 22628564 PMCID: PMC3382517 SCOPUS ID: 2-s2.0-84862583909 05/26/2012       85 Citations
  • Promiscuous archaeal ATP synthase concurrently coupled to Na+ and H+ translocation. (Schlegel K, Leone V, Faraldo-Gómez JD, Müller V) Proc Natl Acad Sci U S A 2012 Jan 17;109(3):947-52 PMID: 22219361 PMCID: PMC3271924 SCOPUS ID: 2-s2.0-84856402809 01/06/2012       108 Citations
  • On the question of hydronium binding to ATP-synthase membrane rotors. (Leone V, Krah A, Faraldo-Gómez JD) Biophys J 2010 Oct 06;99(7):L53-5 PMID: 20923632 PMCID: PMC3042559 SCOPUS ID: 2-s2.0-77958507494 10/07/2010       20 Citations
  • Targeting biomolecular flexibility with metadynamics. (Leone V, Marinelli F, Carloni P, Parrinello M) Curr Opin Struct Biol 2010 Apr;20(2):148-54 PMID: 20171876 SCOPUS ID: 2-s2.0-77951294588 02/23/2010       137 Citations
  • The C-terminal Src inhibitory kinase (Csk)-mediated tyrosine phosphorylation is a novel molecular mechanism to limit P2X3 receptor function in mouse sensory neurons. (D'Arco M, Giniatullin R, Leone V, Carloni P, Birsa N, Nair A, Nistri A, Fabbretti E) J Biol Chem 2009 Aug 07;284(32):21393-401 PMID: 19509283 PMCID: PMC2755864 SCOPUS ID: 2-s2.0-69249129036 06/11/2009       42 Citations
  • Mechanism of action of cyclophilin a explored by metadynamics simulations. (Leone V, Lattanzi G, Molteni C, Carloni P) PLoS Comput Biol 2009 Mar;5(3):e1000309 PMID: 19282959 PMCID: PMC2643488 SCOPUS ID: 2-s2.0-63549093762 03/14/2009       41 Citations
    • Last update: 03/24/2026