Medical College of Wisconsin
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Vera Tarakanova PhD

Vera Tarakanova PhD profile photo picture

Associate Professor

Institution: Medical College of Wisconsin
Department: Microbiology and Immunology

Member of the Cancer Center
Member of the Center for Immunology

Research Experience

  • Ataxia Telangiectasia
  • B-Lymphocytes
  • Cholesterol
  • Gammaherpesvirinae
  • Germinal Center
  • Host-Pathogen Interactions
  • Interferon Regulatory Factor-1
  • Interferon Regulatory Factor-3
  • Interferons
  • Liver X Receptors
  • Macrophages
  • Protein Kinases
  • Virus Latency
  • Publications (56)

  • T Cell-Intrinsic Interleukin 17 Receptor A Signaling Supports the Establishment of Chronic Murine Gammaherpesvirus 68 Infection. (Jondle CN, Tarakanova VL) J Virol 2022 Jun 27:e0063922 PMID: 35758659 06/28/2022    
  • Mouse Homologue of Human HLA-DO Does Not Preempt Autoimmunity but Controls Murine Gammaherpesvirus MHV68. (Lee J, Cullum E, Stoltz K, Bachmann N, Strong Z, Millick DD, Denzin LK, Chang A, Tarakanova V, Chervonsky AV, Golovkina T) J Immunol 2021 Nov 22 PMID: 34810225 PMCID: PMC9124240 11/24/2021    
  • T Cell-Intrinsic Interferon Regulatory Factor 1 Expression Suppresses Differentiation of CD4+ T Cell Populations That Support Chronic Gammaherpesvirus Infection. (Jondle CN, Johnson KE, Mboko WP, Tarakanova VL) J Virol 2021 09 27;95(20):e0072621 PMID: 34346769 PMCID: PMC8475519 SCOPUS ID: 2-s2.0-85116357074 08/05/2021    
  • MyD88 is an essential regulator of NK cell-mediated clearance of MCMV infection. (Dixon KJ, Siebert JR, Wang D, Abel AM, Johnson KE, Riese MJ, Terhune SS, Tarakanova VL, Thakar MS, Malarkannan S) Mol Immunol 2021 09;137:94-104 PMID: 34242922 SCOPUS ID: 2-s2.0-85109126048 07/10/2021    
  • MHC Class II Presentation Is Affected by Polymorphism in the H2-Ob Gene and Additional Loci. (Cullum E, Graves AM, Tarakanova VL, Denzin LK, Golovkina T) J Immunol 2021 07 01;207(1):5-14 PMID: 34135064 PMCID: PMC8674376 SCOPUS ID: 2-s2.0-85109029270 06/18/2021    
  • Conserved Gammaherpesvirus Protein Kinase Counters the Antiviral Effects of Myeloid Cell-Specific STAT1 Expression To Promote the Establishment of Splenic B Cell Latency. (Sylvester PA, Jondle CN, Stoltz KP, Lanham J, Dittel BN, Tarakanova VL) J Virol 2021 08 10;95(17):e0085921 PMID: 34132573 PMCID: PMC8354328 SCOPUS ID: 2-s2.0-85112297903 06/17/2021    
  • Low-Density Lipoprotein Receptor Suppresses the Endogenous Cholesterol Synthesis Pathway To Oppose Gammaherpesvirus Replication in Primary Macrophages. (Aurubin CA, Knaack DA, Sahoo D, Tarakanova VL) J Virol 2021 08 10;95(17):e0064921 PMID: 34105999 PMCID: PMC8354329 SCOPUS ID: 2-s2.0-85112335753 06/10/2021       1 Citation
  • Gammaherpesvirus Usurps Host IL-17 Signaling To Support the Establishment of Chronic Infection. (Jondle CN, Johnson KE, Aurubin C, Sylvester P, Xin G, Cui W, Huppler AR, Tarakanova VL) mBio 2021 04 06;12(2) PMID: 33824206 PMCID: PMC8092251 SCOPUS ID: 2-s2.0-85103513895 04/08/2021       2 Citations
  • Interferon Regulatory Factor 3 Supports the Establishment of Chronic Gammaherpesvirus Infection in a Route- and Dose-Dependent Manner. (Johnson KE, Sylvester PA, Jondle CN, Aurubin CA, Tarakanova VL) J Virol 2021 04 12;95(9) PMID: 33597211 PMCID: PMC8104109 SCOPUS ID: 2-s2.0-85104276444 02/19/2021       1 Citation
  • STING Activated Tumor-Intrinsic Type I Interferon Signaling Promotes CXCR3 Dependent Antitumor Immunity in Pancreatic Cancer. (Vonderhaar EP, Barnekow NS, McAllister D, McOlash L, Eid MA, Riese MJ, Tarakanova VL, Johnson BD, Dwinell MB) Cell Mol Gastroenterol Hepatol 2021;12(1):41-58 PMID: 33548597 PMCID: PMC8081932 SCOPUS ID: 2-s2.0-85104314508 02/07/2021       6 Citations
  • Interferon Regulatory Factor 7 Attenuates Chronic Gammaherpesvirus Infection. (Johnson KE, Aurubin CA, Jondle CN, Lange PT, Tarakanova VL) J Virol 2020 11 23;94(24) PMID: 32967960 PMCID: PMC7925175 SCOPUS ID: 2-s2.0-85096815723 09/25/2020       3 Citations
  • Innate immunity and alpha/gammaherpesviruses: first impressions last a lifetime. (Jondle CN, Tarakanova VL) Curr Opin Virol 2020 10;44:81-89 PMID: 32777757 PMCID: PMC7755754 SCOPUS ID: 2-s2.0-85089150436 08/11/2020       1 Citation
  • B Cell-Intrinsic Expression of Interferon Regulatory Factor 1 Supports Chronic Murine Gammaherpesvirus 68 Infection. (Jondle CN, Johnson KE, Uitenbroek AA, Sylvester PA, Nguyen C, Cui W, Tarakanova VL) J Virol 2020 06 16;94(13) PMID: 32321819 PMCID: PMC7307145 SCOPUS ID: 2-s2.0-85086682413 04/24/2020       5 Citations
  • Gammaherpesviruses and B Cells: A Relationship That Lasts a Lifetime. (Johnson KE, Tarakanova VL) Viral Immunol 2020 05;33(4):316-326 PMID: 31913773 PMCID: PMC7247026 SCOPUS ID: 2-s2.0-85084694556 01/09/2020       7 Citations
  • Antiviral activity of a purine synthesis enzyme reveals a key role of deamidation in regulating protein nuclear import. (Li J, Zhao J, Xu S, Zhang S, Zhang J, Xiao J, Gao R, Tian M, Zeng Y, Lee K, Tarakanova V, Lan K, Feng H, Feng P) Sci Adv 2019 10;5(10):eaaw7373 PMID: 31633017 PMCID: PMC6785261 SCOPUS ID: 2-s2.0-85073598592 10/22/2019       4 Citations
  • B Cell-Intrinsic SHP1 Expression Promotes the Gammaherpesvirus-Driven Germinal Center Response and the Establishment of Chronic Infection. (Johnson KE, Lange PT, Jondle CN, Volberding PJ, Lorenz UM, Cui W, Dittel BN, Tarakanova VL) J Virol 2019 12 12;94(1) PMID: 31597758 PMCID: PMC6912115 SCOPUS ID: 2-s2.0-85076447506 10/11/2019       6 Citations
  • The Role of Metabolic Flexibility in the Regulation of the DNA Damage Response by Nitric Oxide. (Oleson BJ, Broniowska KA, Yeo CT, Flancher M, Naatz A, Hogg N, Tarakanova VL, Corbett JA) Mol Cell Biol 2019 09 15;39(18) PMID: 31235477 PMCID: PMC6712938 SCOPUS ID: 2-s2.0-85071713105 06/27/2019       8 Citations
  • γ-herpesvirus latency attenuates Mycobacterium tuberculosis infection in mice. (Miller HE, Johnson KE, Tarakanova VL, Robinson RT) Tuberculosis (Edinb) 2019 05;116:56-60 PMID: 31153519 PMCID: PMC6876742 SCOPUS ID: 2-s2.0-85065133940 06/04/2019       4 Citations
  • Conserved Gammaherpesvirus Protein Kinase Selectively Promotes Irrelevant B Cell Responses. (Darrah EJ, Jondle CN, Johnson KE, Xin G, Lange PT, Cui W, Olteanu H, Tarakanova VL) J Virol 2019 04 15;93(8) PMID: 30728267 PMCID: PMC6450124 SCOPUS ID: 2-s2.0-85064240079 02/08/2019       10 Citations
  • Chewing the Fat: The Conserved Ability of DNA Viruses to Hijack Cellular Lipid Metabolism. (Lange PT, Lagunoff M, Tarakanova VL) Viruses 2019 01 29;11(2) PMID: 30699959 PMCID: PMC6409581 SCOPUS ID: 2-s2.0-85060921396 02/01/2019       19 Citations
  • LXR Alpha Restricts Gammaherpesvirus Reactivation from Latently Infected Peritoneal Cells. (Lange PT, Jondle CN, Darrah EJ, Johnson KE, Tarakanova VL) J Virol 2019 03 15;93(6) PMID: 30602604 PMCID: PMC6401431 SCOPUS ID: 2-s2.0-85061738072 01/04/2019       12 Citations
  • Single-cell RNA sequencing unveils an IL-10-producing helper subset that sustains humoral immunity during persistent infection. (Xin G, Zander R, Schauder DM, Chen Y, Weinstein JS, Drobyski WR, Tarakanova V, Craft J, Cui W) Nat Commun 2018 11 28;9(1):5037 PMID: 30487586 PMCID: PMC6261948 SCOPUS ID: 2-s2.0-85057571059 11/30/2018       47 Citations
  • Tumor suppressor Interferon Regulatory Factor 1 selectively blocks expression of endogenous retrovirus. (Stoltz KP, Jondle CN, Pulakanti K, Sylvester PA, Urrutia R, Rao S, Tarakanova VL) Virology 2019 01 02;526:52-60 PMID: 30342302 PMCID: PMC6875439 SCOPUS ID: 2-s2.0-85054799725 10/21/2018       4 Citations
  • Liver X Receptors Suppress Activity of Cholesterol and Fatty Acid Synthesis Pathways To Oppose Gammaherpesvirus Replication. (Lange PT, Schorl C, Sahoo D, Tarakanova VL) mBio 2018 07 17;9(4) PMID: 30018108 PMCID: PMC6050960 SCOPUS ID: 2-s2.0-85055540133 07/19/2018       14 Citations
  • Correction for Mounce et al., "A Conserved Gammaherpesvirus Protein Kinase Targets Histone Deacetylases 1 and 2 To Facilitate Viral Replication in Primary Macrophages". (Mounce BC, Mboko WP, Bigley TM, Terhune SS, Tarakanova VL) J Virol 2018 01 01;92(1) PMID: 29242252 PMCID: PMC5730793 SCOPUS ID: 2-s2.0-85037989790 12/16/2017    
  • ATM supports gammaherpesvirus replication by attenuating type I interferon pathway. (Darrah EJ, Stoltz KP, Ledwith M, Tarakanova VL) Virology 2017 10;510:137-146 PMID: 28732227 PMCID: PMC5570481 SCOPUS ID: 2-s2.0-85024386889 07/22/2017       4 Citations
  • B Cell-Specific Expression of Ataxia-Telangiectasia Mutated Protein Kinase Promotes Chronic Gammaherpesvirus Infection. (Darrah EJ, Kulinski JM, Mboko WP, Xin G, Malherbe LP, Gauld SB, Cui W, Tarakanova VL) J Virol 2017 10 01;91(19) PMID: 28701397 PMCID: PMC5599758 SCOPUS ID: 2-s2.0-85029228446 07/14/2017       6 Citations
  • Interferon Regulatory Factor 1 and Type I Interferon Cooperate To Control Acute Gammaherpesvirus Infection. (Mboko WP, Rekow MM, Ledwith MP, Lange PT, Schmitz KE, Anderson S, Tarakanova VL) J Virol 2017 Jan 01;91(1) PMID: 27795415 PMCID: PMC5165188 SCOPUS ID: 2-s2.0-85008186468 11/01/2016       11 Citations
  • Nitric Oxide Suppresses β-Cell Apoptosis by Inhibiting the DNA Damage Response. (Oleson BJ, Broniowska KA, Naatz A, Hogg N, Tarakanova VL, Corbett JA) Mol Cell Biol 2016 08 01;36(15):2067-77 PMID: 27185882 PMCID: PMC4946431 SCOPUS ID: 2-s2.0-85000890117 05/18/2016       24 Citations
  • Gammaherpesvirus targets peritoneal B-1 B cells for long-term latency. (Rekow MM, Darrah EJ, Mboko WP, Lange PT, Tarakanova VL) Virology 2016 May;492:140-4 PMID: 26945150 PMCID: PMC4826794 SCOPUS ID: 2-s2.0-84959386532 03/06/2016       21 Citations
  • Type I Interferon Counteracts Antiviral Effects of Statins in the Context of Gammaherpesvirus Infection. (Lange PT, Darrah EJ, Vonderhaar EP, Mboko WP, Rekow MM, Patel SB, Sidjanin DJ, Tarakanova VL) J Virol 2016 Jan 06;90(7):3342-54 PMID: 26739055 PMCID: PMC4794672 SCOPUS ID: 2-s2.0-84960977475 01/08/2016       8 Citations
  • Tumor Suppressor Interferon-Regulatory Factor 1 Counteracts the Germinal Center Reaction Driven by a Cancer-Associated Gammaherpesvirus. (Mboko WP, Olteanu H, Ray A, Xin G, Darrah EJ, Kumar SN, Kulinski JM, Cui W, Dittel BN, Gauld SB, Tarakanova VL) J Virol 2015 Dec 30;90(6):2818-29 PMID: 26719266 PMCID: PMC4810652 SCOPUS ID: 2-s2.0-84961115924 01/01/2016       13 Citations
  • ATM facilitates mouse gammaherpesvirus reactivation from myeloid cells during chronic infection. (Kulinski JM, Darrah EJ, Broniowska KA, Mboko WP, Mounce BC, Malherbe LP, Corbett JA, Gauld SB, Tarakanova VL) Virology 2015 Sep;483:264-74 PMID: 26001649 PMCID: PMC4516584 SCOPUS ID: 2-s2.0-84929458199 05/24/2015       9 Citations
  • Murine Gammaherpesvirus 68 Pathogenesis Is Independent of Caspase-1 and Caspase-11 in Mice and Impairs Interleukin-1β Production upon Extrinsic Stimulation in Culture. (Cieniewicz B, Dong Q, Li G, Forrest JC, Mounce BC, Tarakanova VL, van der Velden A, Krug LT) J Virol 2015 Jul;89(13):6562-74 PMID: 25855746 PMCID: PMC4468508 SCOPUS ID: 2-s2.0-84930892258 04/10/2015       16 Citations
  • Interferon regulatory factor 1 restricts gammaherpesvirus replication in primary immune cells. (Mboko WP, Mounce BC, Emmer J, Darrah E, Patel SB, Tarakanova VL) J Virol 2014 Jun;88(12):6993-7004 PMID: 24719409 PMCID: PMC4054362 SCOPUS ID: 2-s2.0-84901325260 04/11/2014       38 Citations
  • Nitric oxide induces ataxia telangiectasia mutated (ATM) protein-dependent γH2AX protein formation in pancreatic β cells. (Oleson BJ, Broniowska KA, Schreiber KH, Tarakanova VL, Corbett JA) J Biol Chem 2014 Apr 18;289(16):11454-11464 PMID: 24610783 PMCID: PMC4036281 SCOPUS ID: 2-s2.0-84898944668 03/13/2014       24 Citations
  • Primary macrophages rely on histone deacetylase 1 and 2 expression to induce type I interferon in response to gammaherpesvirus infection. (Mounce BC, Mboko WP, Kanack AJ, Tarakanova VL) J Virol 2014 Feb;88(4):2268-78 PMID: 24335310 PMCID: PMC3911555 SCOPUS ID: 2-s2.0-84893504479 12/18/2013       14 Citations
  • Regulation of antiviral CD8 T-cell responses. (Kulinski JM, Tarakanova VL, Verbsky J) Crit Rev Immunol 2013;33(6):477-88 PMID: 24266346 PMCID: PMC4729194 SCOPUS ID: 2-s2.0-84885207420 11/26/2013       15 Citations
  • Hsp90 inhibitor 17-DMAG decreases expression of conserved herpesvirus protein kinases and reduces virus production in Epstein-Barr virus-infected cells. (Sun X, Bristol JA, Iwahori S, Hagemeier SR, Meng Q, Barlow EA, Fingeroth JD, Tarakanova VL, Kalejta RF, Kenney SC) J Virol 2013 Sep;87(18):10126-38 PMID: 23843639 PMCID: PMC3754017 SCOPUS ID: 2-s2.0-84883294655 07/12/2013       36 Citations
  • Mouse gammaherpesvirus-68 infection acts as a rheostat to set the level of type I interferon signaling in primary macrophages. (Wood BM, Mboko WP, Mounce BC, Tarakanova VL) Virology 2013 Aug 15;443(1):123-33 PMID: 23706314 PMCID: PMC3703304 SCOPUS ID: 2-s2.0-84879783929 05/28/2013       14 Citations
  • A conserved gammaherpesvirus protein kinase targets histone deacetylases 1 and 2 to facilitate viral replication in primary macrophages. (Mounce BC, Mboko WP, Bigley TM, Terhune SS, Tarakanova VL) J Virol 2013 Jul;87(13):7314-25 PMID: 23616648 PMCID: PMC3700300 SCOPUS ID: 2-s2.0-84880360676 04/26/2013       11 Citations
  • Reply to "testing for herpesvirus infection is essential in children with chromosomal-instability syndromes". (Kulinski JM, Tarakanova VL) J Virol 2013 Mar;87(6):3618 PMID: 23436902 PMCID: PMC3592165 SCOPUS ID: 2-s2.0-84874698238 02/26/2013       2 Citations
  • Modulation of B-cell tolerance by murine gammaherpesvirus 68 infection: requirement for Orf73 viral gene expression and follicular helper T cells. (Gauld SB, De Santis JL, Kulinski JM, McGraw JA, Leonardo SM, Ruder EA, Maier W, Tarakanova VL) Immunology 2013 Jun;139(2):197-204 PMID: 23311955 PMCID: PMC3647186 SCOPUS ID: 2-s2.0-84876816256 01/15/2013       10 Citations
  • Ataxia telangiectasia mutated kinase controls chronic gammaherpesvirus infection. (Kulinski JM, Leonardo SM, Mounce BC, Malherbe L, Gauld SB, Tarakanova VL) J Virol 2012 Dec;86(23):12826-37 PMID: 22993144 PMCID: PMC3497635 SCOPUS ID: 2-s2.0-84869205619 09/21/2012       28 Citations
  • Coordinate regulation of DNA damage and type I interferon responses imposes an antiviral state that attenuates mouse gammaherpesvirus type 68 replication in primary macrophages. (Mboko WP, Mounce BC, Wood BM, Kulinski JM, Corbett JA, Tarakanova VL) J Virol 2012 Jun;86(12):6899-912 PMID: 22496235 PMCID: PMC3393547 SCOPUS ID: 2-s2.0-84863993915 04/13/2012       21 Citations
  • Dynamic association of gammaherpesvirus DNA with core histone during de novo lytic infection of primary cells. (Mounce BC, Tsan FC, Kohler S, Cirillo LA, Tarakanova VL) Virology 2011 Dec 20;421(2):167-72 PMID: 22018782 PMCID: PMC3210866 SCOPUS ID: 2-s2.0-80355146848 10/25/2011       14 Citations
  • Gammaherpesvirus gene expression and DNA synthesis are facilitated by viral protein kinase and histone variant H2AX. (Mounce BC, Tsan FC, Droit L, Kohler S, Reitsma JM, Cirillo LA, Tarakanova VL) Virology 2011 Nov 25;420(2):73-81 PMID: 21943826 PMCID: PMC3204369 SCOPUS ID: 2-s2.0-80054053305 09/29/2011       16 Citations
  • Conserved gammaherpesvirus kinase and histone variant H2AX facilitate gammaherpesvirus latency in vivo. (Tarakanova VL, Stanitsa E, Leonardo SM, Bigley TM, Gauld SB) Virology 2010 Sep 15;405(1):50-61 PMID: 20557919 SCOPUS ID: 2-s2.0-77955515217 06/19/2010       33 Citations
  • MHV68 complement regulatory protein facilitates MHV68 replication in primary macrophages in a complement independent manner. (Tarakanova VL, Molleston JM, Goodwin M, Virgin HW 4th) Virology 2010 Jan 20;396(2):323-8 PMID: 19910013 PMCID: PMC2805278 SCOPUS ID: 2-s2.0-70749112365 11/17/2009       10 Citations
  • Adenovirus E1A and E1B-19K proteins protect human hepatoma cells from transforming growth factor beta1-induced apoptosis. (Tarakanova VL, Wold WS) Virus Res 2010 Jan;147(1):67-76 PMID: 19854227 PMCID: PMC2794482 SCOPUS ID: 2-s2.0-71149104683 10/27/2009       3 Citations
  • Gamma-herpesvirus kinase actively initiates a DNA damage response by inducing phosphorylation of H2AX to foster viral replication. (Tarakanova VL, Leung-Pineda V, Hwang S, Yang CW, Matatall K, Basson M, Sun R, Piwnica-Worms H, Sleckman BP, Virgin HW 4th) Cell Host Microbe 2007 Jun 14;1(4):275-86 PMID: 18005708 PMCID: PMC2034359 SCOPUS ID: 2-s2.0-34249910944 11/17/2007       118 Citations
  • Murine gammaherpesvirus 68 genes both induce and suppress lymphoproliferative disease. (Tarakanova VL, Kreisel F, White DW, Virgin HW 4th) J Virol 2008 Jan;82(2):1034-9 PMID: 17977975 PMCID: PMC2224605 SCOPUS ID: 2-s2.0-37849044580 11/06/2007       29 Citations
  • Murine gammaherpesvirus 68 infection is associated with lymphoproliferative disease and lymphoma in BALB beta2 microglobulin-deficient mice. (Tarakanova VL, Suarez F, Tibbetts SA, Jacoby MA, Weck KE, Hess JL, Speck SH, Virgin HW 4th) J Virol 2005 Dec;79(23):14668-79 PMID: 16282467 PMCID: PMC1287585 SCOPUS ID: 2-s2.0-27744535391 11/12/2005       89 Citations
  • Adenovirus DNA binding protein inhibits SrCap-activated CBP and CREB-mediated transcription. (Xu X, Tarakanova V, Chrivia J, Yaciuk P) Virology 2003 Sep 01;313(2):615-21 PMID: 12954226 SCOPUS ID: 2-s2.0-0041885345 09/05/2003       2 Citations
  • Transforming growth factor beta1 receptor II is downregulated by E1A in adenovirus-infected cells. (Tarakanova VL, Wold WS) J Virol 2003 Sep;77(17):9324-36 PMID: 12915548 PMCID: PMC187388 SCOPUS ID: 2-s2.0-0042389592 08/14/2003       9 Citations
  • Radiation increases the activity of oncolytic adenovirus cancer gene therapy vectors that overexpress the ADP (E3-11.6K) protein. (Toth K, Tarakanova V, Doronin K, Ward P, Kuppuswamy M, Locke JE, Dawson JE, Kim HJ, Wold WS) Cancer Gene Ther 2003 Mar;10(3):193-200 PMID: 12637940 SCOPUS ID: 2-s2.0-0037345702 03/15/2003       39 Citations
  • Last update: 06/28/2022