Medical College of Wisconsin
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Weiguo Cui PhD

Weiguo Cui PhD profile photo picture

Associate Professor

Institution: Medical College of Wisconsin
Department: Microbiology and Immunology

Member of the Cancer Center
Member of the Center for Disease Prevention Research (CDPR)


Publications (46)

  • Anti-platelet properties of Pim kinase inhibition is mediated through disruption of thromboxane A2 receptor signalling. (Unsworth AJ, Bye AP, Sage T, Gaspar RS, Eaton N, Drew C, Stainer A, Kriek N, Volberding PJ, Hutchinson JL, Riley R, Jones S, Mundell SJ, Cui W, Falet H, Gibbins JM) Haematologica 2020 May 28 PMID: 32467143 05/30/2020    
  • CD4+ T Cell Help Is Required for the Formation of a Cytolytic CD8+ T Cell Subset that Protects against Chronic Infection and Cancer. (Zander R, Schauder D, Xin G, Nguyen C, Wu X, Zajac A, Cui W) Immunity 2019 12 17;51(6):1028-1042.e4 PMID: 31810883 PMCID: PMC6929322 SCOPUS ID: 2-s2.0-85076189014 12/08/2019       22 Citations
  • Pathogen-Boosted Adoptive Cell Transfer Therapy Induces Endogenous Antitumor Immunity through Antigen Spreading. (Xin G, Khatun A, Topchyan P, Zander R, Volberding PJ, Chen Y, Shen J, Fu C, Jiang A, See WA, Cui W) Cancer Immunol Res 2020 01;8(1):7-18 PMID: 31719059 PMCID: PMC6946848 SCOPUS ID: 2-s2.0-85077667188 11/14/2019       1 Citation
  • Induction of activated T follicular helper cells is critical for anti-FVIII inhibitor development in hemophilia A mice. (Jing W, Chen J, Cai Y, Chen Y, Schroeder JA, Johnson BD, Cui W, Shi Q) Blood Adv 2019 10 22;3(20):3099-3110 PMID: 31648333 PMCID: PMC6849959 SCOPUS ID: 2-s2.0-85074935557 10/28/2019       7 Citations
  • Mitochondrial Metabolic Reprogramming by CD36 Signaling Drives Macrophage Inflammatory Responses. (Chen Y, Yang M, Huang W, Chen W, Zhao Y, Schulte ML, Volberding P, Gerbec Z, Zimmermann MT, Zeighami A, Demos W, Zhang J, Knaack DA, Smith BC, Cui W, Malarkannan S, Sodhi K, Shapiro JI, Xie Z, Sahoo D, Silverstein RL) Circ Res 2019 12 06;125(12):1087-1102 PMID: 31625810 PMCID: PMC6921463 SCOPUS ID: 2-s2.0-85076330129 10/19/2019       8 Citations
  • B Cell-Intrinsic SHP1 Expression Promotes the Gammaherpesvirus-Driven Germinal Center Response and the Establishment of Chronic Infection. (Johnson KE, Lange PT, Jondle CN, Volberding PJ, Lorenz UM, Cui W, Dittel BN, Tarakanova VL) J Virol 2019 12 12;94(1) PMID: 31597758 PMCID: PMC6912115 SCOPUS ID: 2-s2.0-85076447506 10/11/2019       3 Citations
  • CXCR5+PD-1+ follicular helper CD8 T cells control B cell tolerance. (Chen Y, Yu M, Zheng Y, Fu G, Xin G, Zhu W, Luo L, Burns R, Li QZ, Dent AL, Zhu N, Cui W, Malherbe L, Wen R, Wang D) Nat Commun 2019 09 27;10(1):4415 PMID: 31562329 PMCID: PMC6765049 SCOPUS ID: 2-s2.0-85072692451 09/29/2019       6 Citations
  • Conserved Gammaherpesvirus Protein Kinase Selectively Promotes Irrelevant B Cell Responses. (Darrah EJ, Jondle CN, Johnson KE, Xin G, Lange PT, Cui W, Olteanu H, Tarakanova VL) J Virol 2019 04 15;93(8) PMID: 30728267 PMCID: PMC6450124 SCOPUS ID: 2-s2.0-85064240079 02/08/2019       5 Citations
  • Transcriptional and Epigenetic Regulation of Effector and Memory CD8 T Cell Differentiation. (Chen Y, Zander R, Khatun A, Schauder DM, Cui W) Front Immunol 2018;9:2826 PMID: 30581433 PMCID: PMC6292868 SCOPUS ID: 2-s2.0-85058916852 12/26/2018       10 Citations
  • Single-cell RNA sequencing unveils an IL-10-producing helper subset that sustains humoral immunity during persistent infection. (Xin G, Zander R, Schauder DM, Chen Y, Weinstein JS, Drobyski WR, Tarakanova V, Craft J, Cui W) Nat Commun 2018 11 28;9(1):5037 PMID: 30487586 PMCID: PMC6261948 SCOPUS ID: 2-s2.0-85057571059 11/30/2018       24 Citations
  • Frontline Science: PECAM-1 (CD31) expression in naïve and memory, but not acutely activated, CD8+ T cells. (Newman DK, Fu G, McOlash L, Schauder D, Newman PJ, Cui W, Rao S, Johnson BD, Gershan JA, Riese MJ) J Leukoc Biol 2018 11;104(5):883-893 PMID: 30063264 PMCID: PMC6195461 SCOPUS ID: 2-s2.0-85053248137 08/01/2018       5 Citations
  • Diacylglycerol kinase ζ (DGKζ) and Casitas b-lineage proto-oncogene b-deficient mice have similar functional outcomes in T cells but DGKζ-deficient mice have increased T cell activation and tumor clearance. (Wesley EM, Xin G, McAllister D, Malarkannan S, Newman DK, Dwinell MB, Cui W, Johnson BD, Riese MJ) Immunohorizons 2018 Apr 01;2(4):107-118 PMID: 30027154 PMCID: PMC6048965 07/22/2018    
  • Two is better than one: advances in pathogen-boosted immunotherapy and adoptive T-cell therapy. (Xin G, Schauder DM, Zander R, Cui W) Immunotherapy 2017 09;9(10):837-849 PMID: 28877635 PMCID: PMC5941714 SCOPUS ID: 2-s2.0-85028966153 09/08/2017       1 Citation
  • The power of combining adoptive cell therapy (ACT) and pathogen-boosted vaccination to treat solid tumors. (Zander R, Cui W) Hum Vaccin Immunother 2017 10 03;13(10):2269-2271 PMID: 28708956 PMCID: PMC5647994 SCOPUS ID: 2-s2.0-85031923440 07/15/2017    
  • B Cell-Specific Expression of Ataxia-Telangiectasia Mutated Protein Kinase Promotes Chronic Gammaherpesvirus Infection. (Darrah EJ, Kulinski JM, Mboko WP, Xin G, Malherbe LP, Gauld SB, Cui W, Tarakanova VL) J Virol 2017 10 01;91(19) PMID: 28701397 PMCID: PMC5599758 SCOPUS ID: 2-s2.0-85029228446 07/14/2017       2 Citations
  • Cardiotonic Steroids Stimulate Macrophage Inflammatory Responses Through a Pathway Involving CD36, TLR4, and Na/K-ATPase. (Chen Y, Huang W, Yang M, Xin G, Cui W, Xie Z, Silverstein RL) Arterioscler Thromb Vasc Biol 2017 08;37(8):1462-1469 PMID: 28619997 PMCID: PMC5532064 SCOPUS ID: 2-s2.0-85020518621 06/18/2017       10 Citations
  • Pathogen boosted adoptive cell transfer immunotherapy to treat solid tumors. (Xin G, Schauder DM, Jing W, Jiang A, Joshi NS, Johnson B, Cui W) Proc Natl Acad Sci U S A 2017 01 24;114(4):740-745 PMID: 28069963 PMCID: PMC5278465 SCOPUS ID: 2-s2.0-85010648441 01/11/2017       11 Citations
  • Dual Specificity Phosphatase 5 Is Essential for T Cell Survival. (Kutty RG, Xin G, Schauder DM, Cossette SM, Bordas M, Cui W, Ramchandran R) PLoS One 2016;11(12):e0167246 PMID: 27936095 PMCID: PMC5147890 SCOPUS ID: 2-s2.0-85006064690 12/10/2016       11 Citations
  • Transition of T Cells from Effector to Memory Phase (Schauder DM, Cui W) Encyclopedia of Immunobiology 27 April 2016;3:353-362 SCOPUS ID: 2-s2.0-85043292916 04/27/2016    
  • The adhesion molecule PECAM-1 enhances the TGF-β-mediated inhibition of T cell function. (Newman DK, Fu G, Adams T, Cui W, Arumugam V, Bluemn T, Riese MJ) Sci Signal 2016 Mar 08;9(418):ra27 PMID: 26956486 PMCID: PMC5087802 SCOPUS ID: 2-s2.0-84960380725 03/10/2016       8 Citations
  • Tumor Suppressor Interferon-Regulatory Factor 1 Counteracts the Germinal Center Reaction Driven by a Cancer-Associated Gammaherpesvirus. (Mboko WP, Olteanu H, Ray A, Xin G, Darrah EJ, Kumar SN, Kulinski JM, Cui W, Dittel BN, Gauld SB, Tarakanova VL) J Virol 2015 Dec 30;90(6):2818-29 PMID: 26719266 PMCID: PMC4810652 SCOPUS ID: 2-s2.0-84961115924 01/01/2016       9 Citations
  • A Critical Role of IL-21-Induced BATF in Sustaining CD8-T-Cell-Mediated Chronic Viral Control. (Xin G, Schauder DM, Lainez B, Weinstein JS, Dai Z, Chen Y, Esplugues E, Wen R, Wang D, Parish IA, Zajac AJ, Craft J, Cui W) Cell Rep 2015 Nov 10;13(6):1118-1124 PMID: 26527008 PMCID: PMC4859432 SCOPUS ID: 2-s2.0-84946826734 11/04/2015       39 Citations
  • Production of IL-10 by CD4(+) regulatory T cells during the resolution of infection promotes the maturation of memory CD8(+) T cells. (Laidlaw BJ, Cui W, Amezquita RA, Gray SM, Guan T, Lu Y, Kobayashi Y, Flavell RA, Kleinstein SH, Craft J, Kaech SM) Nat Immunol 2015 Aug;16(8):871-9 PMID: 26147684 PMCID: PMC4713030 SCOPUS ID: 2-s2.0-84937816637 07/07/2015       95 Citations
  • β-Catenin in dendritic cells exerts opposite functions in cross-priming and maintenance of CD8+ T cells through regulation of IL-10. (Fu C, Liang X, Cui W, Ober-Blöbaum JL, Vazzana J, Shrikant PA, Lee KP, Clausen BE, Mellman I, Jiang A) Proc Natl Acad Sci U S A 2015 Mar 03;112(9):2823-8 PMID: 25730849 PMCID: PMC4352820 SCOPUS ID: 2-s2.0-84924180359 03/03/2015       48 Citations
  • Kcnn4 is a regulator of macrophage multinucleation in bone homeostasis and inflammatory disease. (Kang H, Kerloc'h A, Rotival M, Xu X, Zhang Q, D'Souza Z, Kim M, Scholz JC, Ko JH, Srivastava PK, Genzen JR, Cui W, Aitman TJ, Game L, Melvin JE, Hanidu A, Dimock J, Zheng J, Souza D, Behera AK, Nabozny G, Cook HT, Bassett JH, Williams GR, Li J, Vignery A, Petretto E, Behmoaras J) Cell Rep 2014 Aug 21;8(4):1210-24 PMID: 25131209 PMCID: PMC4471813 SCOPUS ID: 2-s2.0-84908355965 08/19/2014       29 Citations
  • Chronic viral infection promotes sustained Th1-derived immunoregulatory IL-10 via BLIMP-1. (Parish IA, Marshall HD, Staron MM, Lang PA, Brüstle A, Chen JH, Cui W, Tsui YC, Perry C, Laidlaw BJ, Ohashi PS, Weaver CT, Kaech SM) J Clin Invest 2014 Aug;124(8):3455-68 PMID: 25003188 PMCID: PMC4109559 SCOPUS ID: 2-s2.0-84905482250 07/09/2014       51 Citations
  • TLR4 ligands lipopolysaccharide and monophosphoryl lipid a differentially regulate effector and memory CD8+ T Cell differentiation. (Cui W, Joshi NS, Liu Y, Meng H, Kleinstein SH, Kaech SM) J Immunol 2014 May 01;192(9):4221-32 PMID: 24659688 PMCID: PMC4071140 SCOPUS ID: 2-s2.0-84899499929 03/25/2014       38 Citations
  • β-catenin mediates tumor-induced immunosuppression by inhibiting cross-priming of CD8⁺ T cells. (Liang X, Fu C, Cui W, Ober-Blöbaum JL, Zahner SP, Shrikant PA, Clausen BE, Flavell RA, Mellman I, Jiang A) J Leukoc Biol 2014 Jan;95(1):179-90 PMID: 24023259 SCOPUS ID: 2-s2.0-84897019410 09/12/2013       35 Citations
  • Transcriptional control of effector and memory CD8+ T cell differentiation. (Kaech SM, Cui W) Nat Rev Immunol 2012 Nov;12(11):749-61 PMID: 23080391 PMCID: PMC4137483 SCOPUS ID: 2-s2.0-84867896903 10/20/2012       644 Citations
  • Role of sustained antigen release from nanoparticle vaccines in shaping the T cell memory phenotype. (Demento SL, Cui W, Criscione JM, Stern E, Tulipan J, Kaech SM, Fahmy TM) Biomaterials 2012 Jun;33(19):4957-64 PMID: 22484047 PMCID: PMC5724530 SCOPUS ID: 2-s2.0-84859838781 04/10/2012       155 Citations
  • An interleukin-21-interleukin-10-STAT3 pathway is critical for functional maturation of memory CD8+ T cells. (Cui W, Liu Y, Weinstein JS, Craft J, Kaech SM) Immunity 2011 Nov 23;35(5):792-805 PMID: 22118527 PMCID: PMC3431922 SCOPUS ID: 2-s2.0-82055208627 11/29/2011       217 Citations
  • Differential expression of Ly6C and T-bet distinguish effector and memory Th1 CD4(+) cell properties during viral infection. (Marshall HD, Chandele A, Jung YW, Meng H, Poholek AC, Parish IA, Rutishauser R, Cui W, Kleinstein SH, Craft J, Kaech SM) Immunity 2011 Oct 28;35(4):633-46 PMID: 22018471 PMCID: PMC3444169 SCOPUS ID: 2-s2.0-80755163540 10/25/2011       161 Citations
  • Mechanisms of antigen presentation to T cells in murine graft-versus-host disease: cross-presentation and the appearance of cross-presentation. (Wang X, Li H, Matte-Martone C, Cui W, Li N, Tan HS, Roopenian D, Shlomchik WD) Blood 2011 Dec 08;118(24):6426-37 PMID: 21963602 PMCID: PMC3236124 SCOPUS ID: 2-s2.0-83455219332 10/04/2011       38 Citations
  • Increased numbers of preexisting memory CD8 T cells and decreased T-bet expression can restrain terminal differentiation of secondary effector and memory CD8 T cells. (Joshi NS, Cui W, Dominguez CX, Chen JH, Hand TW, Kaech SM) J Immunol 2011 Oct 15;187(8):4068-76 PMID: 21930973 PMCID: PMC3991478 SCOPUS ID: 2-s2.0-80054722812 09/21/2011       58 Citations
  • Memory T cells from minor histocompatibility antigen-vaccinated and virus-immune donors improve GVL and immune reconstitution. (Li N, Matte-Martone C, Zheng H, Cui W, Venkatesan S, Tan HS, McNiff J, Demetris AJ, Roopenian D, Kaech S, Shlomchik WD) Blood 2011 Nov 24;118(22):5965-76 PMID: 21917752 PMCID: PMC3228506 SCOPUS ID: 2-s2.0-82155178605 09/16/2011       34 Citations
  • Differential effects of STAT5 and PI3K/AKT signaling on effector and memory CD8 T-cell survival. (Hand TW, Cui W, Jung YW, Sefik E, Joshi NS, Chandele A, Liu Y, Kaech SM) Proc Natl Acad Sci U S A 2010 Sep 21;107(38):16601-6 PMID: 20823247 PMCID: PMC2944719 SCOPUS ID: 2-s2.0-78049268109 09/09/2010       125 Citations
  • TLR9-targeted biodegradable nanoparticles as immunization vectors protect against West Nile encephalitis. (Demento SL, Bonafé N, Cui W, Kaech SM, Caplan MJ, Fikrig E, Ledizet M, Fahmy TM) J Immunol 2010 Sep 01;185(5):2989-97 PMID: 20660705 PMCID: PMC3753007 SCOPUS ID: 2-s2.0-78049361384 07/28/2010       86 Citations
  • Generation of effector CD8+ T cells and their conversion to memory T cells. (Cui W, Kaech SM) Immunol Rev 2010 Jul;236:151-66 PMID: 20636815 PMCID: PMC4380273 SCOPUS ID: 2-s2.0-77953749960 07/20/2010       138 Citations
  • Role of MKP-1 in osteoclasts and bone homeostasis. (Carlson J, Cui W, Zhang Q, Xu X, Mercan F, Bennett AM, Vignery A) Am J Pathol 2009 Oct;175(4):1564-73 PMID: 19762714 PMCID: PMC2751553 SCOPUS ID: 2-s2.0-73549120650 09/19/2009       27 Citations
  • Effects of Signal 3 during CD8 T cell priming: Bystander production of IL-12 enhances effector T cell expansion but promotes terminal differentiation. (Cui W, Joshi NS, Jiang A, Kaech SM) Vaccine 2009 Mar 26;27(15):2177-87 PMID: 19201385 PMCID: PMC2803112 SCOPUS ID: 2-s2.0-61549120751 02/10/2009       82 Citations
  • MyD88 plays a critical T cell-intrinsic role in supporting CD8 T cell expansion during acute lymphocytic choriomeningitis virus infection. (Rahman AH, Cui W, Larosa DF, Taylor DK, Zhang J, Goldstein DR, Wherry EJ, Kaech SM, Turka LA) J Immunol 2008 Sep 15;181(6):3804-10 PMID: 18768833 PMCID: PMC2835404 SCOPUS ID: 2-s2.0-56149110848 09/05/2008       56 Citations
  • Disruption of E-cadherin-mediated adhesion induces a functionally distinct pathway of dendritic cell maturation. (Jiang A, Bloom O, Ono S, Cui W, Unternaehrer J, Jiang S, Whitney JA, Connolly J, Banchereau J, Mellman I) Immunity 2007 Oct;27(4):610-24 PMID: 17936032 PMCID: PMC2151979 SCOPUS ID: 2-s2.0-35348968837 10/16/2007       246 Citations
  • CD200 and its receptor, CD200R, modulate bone mass via the differentiation of osteoclasts. (Cui W, Cuartas E, Ke J, Zhang Q, Einarsson HB, Sedgwick JD, Li J, Vignery A) Proc Natl Acad Sci U S A 2007 Sep 04;104(36):14436-41 PMID: 17726108 PMCID: PMC1955461 SCOPUS ID: 2-s2.0-35448947277 08/30/2007       59 Citations
  • Inflammation directs memory precursor and short-lived effector CD8(+) T cell fates via the graded expression of T-bet transcription factor. (Joshi NS, Cui W, Chandele A, Lee HK, Urso DR, Hagman J, Gapin L, Kaech SM) Immunity 2007 Aug;27(2):281-95 PMID: 17723218 PMCID: PMC2034442 SCOPUS ID: 2-s2.0-34548027000 08/29/2007       1011 Citations
  • The intracellular domain of CD44 promotes the fusion of macrophages. (Cui W, Ke JZ, Zhang Q, Ke HZ, Chalouni C, Vignery A) Blood 2006 Jan 15;107(2):796-805 PMID: 16195325 PMCID: PMC1473173 SCOPUS ID: 2-s2.0-30444441681 10/01/2005       82 Citations
  • IL-1 receptor-associated kinase M is a central regulator of osteoclast differentiation and activation. (Li H, Cuartas E, Cui W, Choi Y, Crawford TD, Ke HZ, Kobayashi KS, Flavell RA, Vignery A) J Exp Med 2005 Apr 04;201(7):1169-77 PMID: 15809356 PMCID: PMC2213136 SCOPUS ID: 2-s2.0-17144367325 04/06/2005       52 Citations
  • Last update: 05/30/2020
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