William E. Hughes PhD

Research Areas of Interest
Adrenergic alpha-1 Receptor AgonistsAgingArterial PressureArteriolesAutophagyAutophagy-Related ProteinsBlood Flow VelocityBlood PressureCardiorespiratory FitnessCerebrovascular CirculationCoronary Artery DiseaseDiabetes Mellitus, Type 2Endothelial CellsExerciseHemodynamicsHumansHydrogen PeroxideHypertensionHypoxiaLower Body Negative PressureLysosomesMiddle Cerebral ArteryMuscle ContractionNitric OxideOxygen ConsumptionPeripheral Arterial DiseasePulsatile FlowPulse Wave AnalysisReflexRegional Blood FlowSympathetic Nervous SystemUltrasonography, DopplerVascular StiffnessVasoconstrictionVasodilationResearch Experience
Adrenergic alpha-1 Receptor AgonistsAgedAgingArterial PressureArteriolesAutophagyAutophagy-Related ProteinsBlood Flow VelocityBlood PressureCardiorespiratory FitnessCase-Control StudiesCerebrovascular CirculationCoronary Artery DiseaseCoronary VesselsDiabetes Mellitus, Type 2Dietary SupplementsEndothelial CellsExerciseFemoral ArteryHealthy VolunteersHemodynamicsHumansHydrogen PeroxideHypertensionHypoxiaLower Body Negative PressureLysosomesMiddle Cerebral ArteryMuscle ContractionMuscle, SkeletalNitratesNitric OxideNitritesOxygen ConsumptionPeripheral Arterial DiseasePulsatile FlowPulse Wave AnalysisReflexRegional Blood FlowSympathetic Nervous SystemUltrasonography, DopplerVascular StiffnessVasoconstrictionVasodilationVasodilator AgentsMethodologies and Techniques
Blood Flow VelocityBrachial ArteryCardiorespiratory FitnessCase-Control StudiesCross-Over StudiesDietary SupplementsFemoral ArteryHealthy VolunteersHypoxiaMuscle ContractionPulse Wave AnalysisReflexRegional Blood FlowUltrasonography, DopplerVascular StiffnessVasodilator AgentsPublications (41)
Lipid phosphate phosphatase 3 maintains NO-mediated flow-mediated dilatation in human adipose resistance arterioles. (Chabowski DS, Hughes WE, Hockenberry JC, LoGiudice J, Beyer AM, Gutterman DD) J Physiol 2023 Feb;601(3):469-481 PMID: 36575638 PMCID: PMC10979460 SCOPUS ID: 2-s2.0-85145823691 12/29/2022 5 CitationsEffects of Combined Inorganic Nitrate and Nitrite Supplementation on Cardiorespiratory Fitness and Skeletal Muscle Oxidative Capacity in Type 2 Diabetes: A Pilot Randomized Controlled Trial. (Turner KD, Kronemberger A, Bae D, Bock JM, Hughes WE, Ueda K, Feider AJ, Hanada S, de Sousa LGO, Harris MP, Anderson EJ, Bodine SC, Zimmerman MB, Casey DP, Lira VA) Nutrients 2022 Oct 25;14(21) PMID: 36364742 PMCID: PMC9654804 SCOPUS ID: 2-s2.0-85141586381 11/12/2022 11 CitationsNoncanonical Role of Telomerase in Regulation of Microvascular Redox Environment With Implications for Coronary Artery Disease. (Ait-Aissa K, Norwood-Toro LE, Terwoord J, Young M, Paniagua LA, Hader SN, Hughes WE, Hockenberry JC, Beare JE, Linn J, Kohmoto T, Kim J, Betts DH, LeBlanc AJ, Gutterman DD, Beyer AM) Function (Oxf) 2022;3(5):zqac043 PMID: 36168588 PMCID: PMC9508843 SCOPUS ID: 2-s2.0-85140334290 09/29/2022 14 CitationsDietary Inorganic Nitrate/Nitrite Supplementation Reduces Central and Peripheral Blood Pressure in Patients With Type 2 Diabetes Mellitus. (Bock JM, Hughes WE, Ueda K, Feider AJ, Hanada S, Casey DP) Am J Hypertens 2022 Sep 01;35(9):803-809 PMID: 35639721 PMCID: PMC9434218 SCOPUS ID: 2-s2.0-85137138698 06/01/2022 10 CitationsSodium nitrate supplementation improves blood pressure reactivity in patients with peripheral artery disease. (Hughes WE, Treichler DP, Ueda K, Bock JM, Casey DP) Nutr Metab Cardiovasc Dis 2022 Mar;32(3):710-714 PMID: 35090799 PMCID: PMC8857030 SCOPUS ID: 2-s2.0-85123693710 01/30/2022 4 CitationsModulation of p66Shc impairs cerebrovascular myogenic tone in low renin but not low nitric oxide models of systemic hypertension. (Hughes WE, Hockenberry J, Miller B, Sorokin A, Beyer AM) Am J Physiol Heart Circ Physiol 2021 Dec 01;321(6):H1096-H1102 PMID: 34714691 PMCID: PMC8834231 SCOPUS ID: 2-s2.0-85120604529 10/30/2021 6 CitationsAutophagy, TERT, and mitochondrial dysfunction in hyperoxia. (Beyer AM, Norwood Toro LE, Hughes WE, Young M, Clough AV, Gao F, Medhora M, Audi SH, Jacobs ER) Am J Physiol Heart Circ Physiol 2021 Nov 01;321(5):H985-H1003 PMID: 34559580 PMCID: PMC8616608 SCOPUS ID: 2-s2.0-85120657950 09/25/2021 28 CitationsGlycemic management is inversely related to skeletal muscle microvascular endothelial function in patients with type 2 diabetes. (Bock JM, Hughes WE, Ueda K, Feider AJ, Hanada S, Casey DP) Physiol Rep 2021 Mar;9(5):e14764 PMID: 33660935 PMCID: PMC7931618 SCOPUS ID: 2-s2.0-85102482529 03/05/2021 5 CitationsGuidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1. (Klionsky DJ, Abdel-Aziz AK, Abdelfatah S, Abdellatif M, Abdoli A, Abel S, Abeliovich H, Abildgaard MH, Abudu YP, Acevedo-Arozena A, Adamopoulos IE, Adeli K, Adolph TE, Adornetto A, Aflaki E, Agam G, Agarwal A, Aggarwal BB, Agnello M, Agostinis P, Agrewala JN, Agrotis A, Aguilar PV, Ahmad ST, Ahmed ZM, Ahumada-Castro U, Aits S, Aizawa S, Akkoc Y, Akoumianaki T, Akpinar HA, Al-Abd AM, Al-Akra L, Al-Gharaibeh A, Alaoui-Jamali MA, Alberti S, Alcocer-Gómez E, Alessandri C, Ali M, Alim Al-Bari MA, Aliwaini S, Alizadeh J, Almacellas E, Almasan A, Alonso A, Alonso GD, Altan-Bonnet N, Altieri DC, Álvarez ÉMC, Alves S, Alves da Costa C, Alzaharna MM, Amadio M, Amantini C, Amaral C, Ambrosio S, Amer AO, Ammanathan V, An Z, Andersen SU, Andrabi SA, Andrade-Silva M, Andres AM, Angelini S, Ann D, Anozie UC, Ansari MY, Antas P, Antebi A, Antón Z, Anwar T, Apetoh L, Apostolova N, Araki T, Araki Y, Arasaki K, Araújo WL, Araya J, Arden C, Arévalo MA, Arguelles S, Arias E, Arikkath J, Arimoto H, Ariosa AR, Armstrong-James D, Arnauné-Pelloquin L, Aroca A, Arroyo DS, Arsov I, Artero R, Asaro DML, Aschner M, Ashrafizadeh M, Ashur-Fabian O, Atanasov AG, Au AK, Auberger P, Auner HW, Aurelian L, Autelli R, Avagliano L, Ávalos Y, Aveic S, Aveleira CA, Avin-Wittenberg T, Aydin Y, Ayton S, Ayyadevara S, Azzopardi M, Baba M, Backer JM, Backues SK, Bae DH, Bae ON, Bae SH, Baehrecke EH, Baek A, Baek SH, Baek SH, Bagetta G, Bagniewska-Zadworna A, Bai H, Bai J, Bai X, Bai Y, Bairagi N, Baksi S, Balbi T, Baldari CT, Balduini W, Ballabio A, Ballester M, Balazadeh S, Balzan R, Bandopadhyay R, Banerjee S, Banerjee S, Bánréti Á, Bao Y, Baptista MS, Baracca A, Barbati C, Bargiela A, Barilà D, Barlow PG, Barmada SJ, Barreiro E, Barreto GE, Bartek J, Bartel B, Bartolome A, Barve GR, Basagoudanavar SH, Bassham DC, Bast RC Jr, Basu A, Batoko H, Batten I, Baulieu EE, Baumgarner BL, Bayry J, Beale R, Beau I, Beaumatin F, Bechara LRG, Beck GR Jr, Beers MF, Begun J, Behrends C, Behrens GMN, Bei R, Bejarano E, Bel S, Behl C, Belaid A, Belgareh-Touzé N, Bellarosa C, Belleudi F, Belló Pérez M, Bello-Morales R, Beltran JSO, Beltran S, Benbrook DM, Bendorius M, Benitez BA, Benito-Cuesta I, Bensalem J, Berchtold MW, Berezowska S, Bergamaschi D, Bergami M, Bergmann A, Berliocchi L, Berlioz-Torrent C, Bernard A, Berthoux L, Besirli CG, Besteiro S, Betin VM, Beyaert R, Bezbradica JS, Bhaskar K, Bhatia-Kissova I, Bhattacharya R, Bhattacharya S, Bhattacharyya S, Bhuiyan MS, Bhutia SK, Bi L, Bi X, Biden TJ, Bijian K, Billes VA, Binart N, Bincoletto C, Birgisdottir AB, Bjorkoy G, Blanco G, Blas-Garcia A, Blasiak J, Blomgran R, Blomgren K, Blum JS, Boada-Romero E, Boban M, Boesze-Battaglia K, Boeuf P, Boland B, Bomont P, Bonaldo P, Bonam SR, Bonfili L, Bonifacino JS, Boone BA, Bootman MD, Bordi M, Borner C, Bornhauser BC, Borthakur G, Bosch J, Bose S, Botana LM, Botas J, Boulanger CM, Boulton ME, Bourdenx M, Bourgeois B, Bourke NM, Bousquet G, Boya P, Bozhkov PV, Bozi LHM, Bozkurt TO, Brackney DE, Brandts CH, Braun RJ, Braus GH, Bravo-Sagua R, Bravo-San Pedro JM, Brest P, Bringer MA, Briones-Herrera A, Broaddus VC, Brodersen P, Brodsky JL, Brody SL, Bronson PG, Bronstein JM, Brown CN, Brown RE, Brum PC, Brumell JH, Brunetti-Pierri N, Bruno D, Bryson-Richardson RJ, Bucci C, Buchrieser C, Bueno M, Buitrago-Molina LE, Buraschi S, Buch S, Buchan JR, Buckingham EM, Budak H, Budini M, Bultynck G, Burada F, Burgoyne JR, Burón MI, Bustos V, Büttner S, Butturini E, Byrd A, Cabas I, Cabrera-Benitez S, Cadwell K, Cai J, Cai L, Cai Q, Cairó M, Calbet JA, Caldwell GA, Caldwell KA, Call JA, Calvani R, Calvo AC, Calvo-Rubio Barrera M, Camara NO, Camonis JH, Camougrand N, Campanella M, Campbell EM, Campbell-Valois FX, Campello S, Campesi I, Campos JC, Camuzard O, Cancino J, Candido de Almeida D, Canesi L, Caniggia I, Canonico B, Cantí C, Cao B, Caraglia M, Caramés B, Carchman EH, Cardenal-Muñoz E, Cardenas C, Cardenas L, Cardoso SM, Carew JS, Carle GF, Carleton G, Carloni S, Carmo) Autophagy 2021 Jan;17(1):1-382 PMID: 33634751 PMCID: PMC7996087 SCOPUS ID: 2-s2.0-85102619204 02/27/2021 2044 CitationsHypertension preserves the magnitude of microvascular flow-mediated dilation following transient elevation in intraluminal pressure. (Hughes WE, Zinkevich N, Gutterman DD, Beyer AM) Physiol Rep 2021 Feb;9(3):e14507 PMID: 33587335 PMCID: PMC7883808 SCOPUS ID: 2-s2.0-85100849665 02/16/2021 4 CitationsCritical Interaction Between Telomerase and Autophagy in Mediating Flow-Induced Human Arteriolar Vasodilation. (Hughes WE, Chabowski DS, Ait-Aissa K, Fetterman JL, Hockenberry J, Beyer AM, Gutterman DD) Arterioscler Thromb Vasc Biol 2021 Jan;41(1):446-457 PMID: 33232201 PMCID: PMC7770118 SCOPUS ID: 2-s2.0-85098224505 11/25/2020 20 CitationsGreater α1-adrenergic-mediated vasoconstriction in contracting skeletal muscle of patients with type 2 diabetes. (Bock JM, Hughes WE, Ueda K, Feider AJ, Hanada S, Kruse NT, Iwamoto E, Casey DP) Am J Physiol Heart Circ Physiol 2020 Oct 01;319(4):H797-H807 PMID: 32822215 SCOPUS ID: 2-s2.0-85091470238 08/22/2020 15 CitationsVascular autophagy in health and disease. (Hughes WE, Beyer AM, Gutterman DD) Basic Res Cardiol 2020 Jun 06;115(4):41 PMID: 32506214 PMCID: PMC12306491 SCOPUS ID: 2-s2.0-85086002230 06/09/2020 67 CitationsDietary nitrate does not acutely enhance skeletal muscle blood flow and vasodilation in the lower limbs of older adults during single-limb exercise. (Hughes WE, Kruse NT, Ueda K, Feider AJ, Hanada S, Bock JM, Casey DP) Eur J Appl Physiol 2020 Jun;120(6):1357-1369 PMID: 32303829 SCOPUS ID: 2-s2.0-85083592813 04/19/2020 9 CitationsEffects of Whey Protein Supplementation on Aortic Stiffness, Cerebral Blood Flow, and Cognitive Function in Community-Dwelling Older Adults: Findings from the ANCHORS A-WHEY Clinical Trial. (Lefferts WK, Augustine JA, Spartano NL, Hughes WE, Babcock MC, Heenan BK, Heffernan KS) Nutrients 2020 Apr 10;12(4) PMID: 32290271 PMCID: PMC7230701 SCOPUS ID: 2-s2.0-85083407169 04/16/2020 13 CitationsAge-Associated Differences in Central Artery Responsiveness to Sympathoexcitatory Stimuli. (Bock JM, Hughes WE, Casey DP) Am J Hypertens 2019 May 09;32(6):564-569 PMID: 30854541 SCOPUS ID: 2-s2.0-85065879427 03/12/2019 8 CitationsVascular autophagy in physiology and pathology. (Hughes WE, Beyer AM) Am J Physiol Heart Circ Physiol 2019 Jan 01;316(1):H183-H185 PMID: 30412440 PMCID: PMC6383357 SCOPUS ID: 2-s2.0-85059796597 11/10/2018 6 CitationsInorganic nitrate supplementation enhances functional capacity and lower-limb microvascular reactivity in patients with peripheral artery disease. (Bock JM, Treichler DP, Norton SL, Ueda K, Hughes WE, Casey DP) Nitric Oxide 2018 Nov 01;80:45-51 PMID: 30118808 PMCID: PMC6239203 SCOPUS ID: 2-s2.0-85051631115 08/18/2018 28 CitationsReduced blood pressure responsiveness to skeletal muscle metaboreflex activation in older adults following inorganic nitrate supplementation. (Schneider AC, Hughes WE, Ueda K, Bock JM, Casey DP) Nitric Oxide 2018 Aug 01;78:81-88 PMID: 29864505 SCOPUS ID: 2-s2.0-85048138882 06/05/2018 25 CitationsHabitual exercise training in older adults offsets the age-related prolongation in leg vasodilator kinetics during single-limb lower body exercise. (Hughes WE, Kruse NT, Ueda K, Casey DP) J Appl Physiol (1985) 2018 Sep 01;125(3):746-754 PMID: 29856264 PMCID: PMC6842877 SCOPUS ID: 2-s2.0-85053844349 06/02/2018 3 CitationsMechanistic insights into the modulatory role of the mechanoreflex on central hemodynamics using passive leg movement in humans. (Kruse NT, Hughes WE, Casey DP) J Appl Physiol (1985) 2018 Aug 01;125(2):545-552 PMID: 29771607 PMCID: PMC6139517 SCOPUS ID: 2-s2.0-85056641320 05/18/2018 12 CitationsImpaired modulation of postjunctional α1 - but not α2 -adrenergic vasoconstriction in contracting forearm muscle of postmenopausal women. (Kruse NT, Hughes WE, Ueda K, Hanada S, Feider AJ, Iwamoto E, Bock JM, Casey DP) J Physiol 2018 Jul;596(13):2507-2519 PMID: 29708589 PMCID: PMC6023827 SCOPUS ID: 2-s2.0-85047805028 05/01/2018 6 CitationsAcute Effects of Interrupting Sitting on Discomfort and Alertness of Office Workers. (Benzo RM, Kruse NT, Hughes WE, Casey DP, Carr LJ) J Occup Environ Med 2018 Sep;60(9):804-809 PMID: 29608539 SCOPUS ID: 2-s2.0-85056551724 04/03/2018 12 CitationsAge-associated impairments in contraction-induced rapid-onset vasodilatation within the forearm are independent of mechanical factors. (Hughes WE, Kruse NT, Casey DP) Exp Physiol 2018 May 01;103(5):728-737 PMID: 29528524 PMCID: PMC5927837 SCOPUS ID: 2-s2.0-85045260442 03/13/2018 3 CitationsEight weeks of nitrate supplementation improves blood flow and reduces the exaggerated pressor response during forearm exercise in peripheral artery disease. (Kruse NT, Ueda K, Hughes WE, Casey DP) Am J Physiol Heart Circ Physiol 2018 Jul 01;315(1):H101-H108 PMID: 29522355 PMCID: PMC6087779 SCOPUS ID: 2-s2.0-85051235677 03/10/2018 20 CitationsSignalling of vasodilatation across an exercise transient. (Hughes WE) J Physiol 2018 Feb 15;596(4):559-560 PMID: 29282738 PMCID: PMC5813600 SCOPUS ID: 2-s2.0-85041002840 12/29/2017 2 CitationsArterial stiffness and cerebral hemodynamic pulsatility during cognitive engagement in younger and older adults. (Heffernan KS, Augustine JA, Lefferts WK, Spartano NL, Hughes WE, Jorgensen RS, Gump BB) Exp Gerontol 2018 Jan;101:54-62 PMID: 29129735 SCOPUS ID: 2-s2.0-85036531071 11/14/2017 21 CitationsWorkplace Strategies to Prevent Sitting-induced Endothelial Dysfunction. (Kruse NT, Hughes WE, Benzo RM, Carr LJ, Casey DP) Med Sci Sports Exerc 2018 Apr;50(4):801-808 PMID: 29117072 SCOPUS ID: 2-s2.0-85044022590 11/09/2017 42 CitationsInorganic nitrate supplementation attenuates peripheral chemoreflex sensitivity but does not improve cardiovagal baroreflex sensitivity in older adults. (Bock JM, Ueda K, Schneider AC, Hughes WE, Limberg JK, Bryan NS, Casey DP) Am J Physiol Heart Circ Physiol 2018 Jan 01;314(1):H45-H51 PMID: 28971842 PMCID: PMC6048463 SCOPUS ID: 2-s2.0-85043465428 10/04/2017 24 CitationsEvidence of a greater functional sympatholysis in habitually aerobic trained postmenopausal women. (Kruse NT, Hughes WE, Hanada S, Ueda K, Bock JM, Iwamoto E, Casey DP) J Appl Physiol (1985) 2018 Mar 01;124(3):583-591 PMID: 28970201 PMCID: PMC5899268 SCOPUS ID: 2-s2.0-85043603765 10/04/2017 15 CitationsVasoconstrictor responsiveness in contracting human muscle: influence of contraction frequency, contractile work, and metabolic rate. (Kruse NT, Hughes WE, Ueda K, Casey DP) Eur J Appl Physiol 2017 Aug;117(8):1697-1706 PMID: 28624852 SCOPUS ID: 2-s2.0-85020536710 06/19/2017 5 CitationsSympathetic nervous system activation reduces contraction-induced rapid vasodilation in the leg of humans independent of age. (Hughes WE, Kruse NT, Casey DP) J Appl Physiol (1985) 2017 Jul 01;123(1):106-115 PMID: 28385914 PMCID: PMC6157482 SCOPUS ID: 2-s2.0-85021939278 04/08/2017 7 CitationsAortic Wave Reflection During Orthostatic Challenges: Influence of Body Position and Venous Pooling. (Hughes WE, Casey DP) Am J Hypertens 2017 Feb;30(2):166-172 PMID: 28077421 SCOPUS ID: 2-s2.0-85016029331 01/13/2017 6 CitationsEffects of acute dietary nitrate supplementation on aortic blood pressure and aortic augmentation index in young and older adults. (Hughes WE, Ueda K, Treichler DP, Casey DP) Nitric Oxide 2016 Sep 30;59:21-7 PMID: 27373229 SCOPUS ID: 2-s2.0-84978414661 07/05/2016 37 CitationsChronic endurance exercise training offsets the age-related attenuation in contraction-induced rapid vasodilation. (Hughes WE, Ueda K, Casey DP) J Appl Physiol (1985) 2016 Jun 01;120(11):1335-42 PMID: 27032899 PMCID: PMC4891932 SCOPUS ID: 2-s2.0-84983627595 04/02/2016 13 CitationsA 'passive' movement into the future of assessing endothelial dysfunction? (Hughes WE, Kruse NT) J Physiol 2016 Mar 15;594(6):1525-6 PMID: 26995261 PMCID: PMC4799980 SCOPUS ID: 2-s2.0-84962600161 03/21/2016 2 CitationsEffect of acute nitrate supplementation on neurovascular coupling and cognitive performance in hypoxia. (Lefferts WK, Hughes WE, White CN, Brutsaert TD, Heffernan KS) Appl Physiol Nutr Metab 2016 Feb;41(2):133-41 PMID: 26751937 SCOPUS ID: 2-s2.0-84951846665 01/12/2016 33 CitationsEffect of acute nitrate ingestion on central hemodynamic load in hypoxia. (Lefferts WK, Hughes WE, Heffernan KS) Nitric Oxide 2016 Jan 30;52:49-55 PMID: 26679695 SCOPUS ID: 2-s2.0-84951853987 12/19/2015 7 CitationsRapid onset vasodilation with single muscle contractions in the leg: influence of age. (Hughes WE, Ueda K, Treichler DP, Casey DP) Physiol Rep 2015 Aug;3(8) PMID: 26320213 PMCID: PMC4562596 SCOPUS ID: 2-s2.0-84962589221 09/01/2015 17 CitationsEffect of acute high-intensity resistance exercise on optic nerve sheath diameter and ophthalmic artery blood flow pulsatility. (Lefferts WK, Hughes WE, Heffernan KS) J Hum Hypertens 2015 Dec;29(12):744-8 PMID: 25739332 SCOPUS ID: 2-s2.0-84947048338 03/06/2015 15 CitationsAcute effect of high-intensity cycling exercise on carotid artery hemodynamic pulsatility. (Babcock MC, Lefferts WK, Hughes WE, Fitzgerald KL, Leyer BK, Redmond JG, Heffernan KS) Eur J Appl Physiol 2015 May;115(5):1037-45 PMID: 25543325 SCOPUS ID: 2-s2.0-84928329196 12/30/2014 26 Citations Last update: 09/27/2024