Medical College of Wisconsin
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Xiao-Mei Qi MD

Xiao-Mei Qi MD profile photo picture

Associate Professor

Institution: Medical College of Wisconsin
Department: Pharmacology and Toxicology
Program: Pharmacology

Member of the Cancer Center


Research Experience

  • Signal transduction in cancer
  • Educational Expertise

  • Supervise new postdoc and graduate students for their daily experiments
  • Publications (20)

  • p38γ MAPK Is Essential for Aerobic Glycolysis and Pancreatic Tumorigenesis. (Wang F, Qi XM, Wertz R, Mortensen M, Hagen C, Evans J, Sheinin Y, James M, Liu P, Tsai S, Thomas J, Mackinnon A, Dwinell M, Myers CR, Bartrons Bach R, Fu L, Chen G) Cancer Res 2020 Aug 15;80(16):3251-3264 PMID: 32580961 SCOPUS ID: 2-s2.0-85089787021 06/26/2020    
  • Targeting an oncogenic kinase/phosphatase signaling network for cancer therapy. (Qi XM, Wang F, Mortensen M, Wertz R, Chen G) Acta Pharm Sin B 2018 Jul;8(4):511-517 PMID: 30109176 PMCID: PMC6089844 SCOPUS ID: 2-s2.0-85048878016 08/16/2018    
  • Nogo-B receptor promotes epithelial-mesenchymal transition in non-small cell lung cancer cells through the Ras/ERK/Snail1 pathway. (Wu D, Zhao B, Qi X, Peng F, Fu H, Chi X, Miao QR, Shao S) Cancer Lett 2018 04 01;418:135-146 PMID: 29331415 PMCID: PMC7385903 01/15/2018       15 Citations
  • Tyrosine dephosphorylation enhances the therapeutic target activity of epidermal growth factor receptor (EGFR) by disrupting its interaction with estrogen receptor (ER). (Ma S, Yin N, Qi X, Pfister SL, Zhang MJ, Ma R, Chen G) Oncotarget 2015 May 30;6(15):13320-33 PMID: 26079946 PMCID: PMC4537017 SCOPUS ID: 2-s2.0-84931073824 06/17/2015       10 Citations
  • p38γ MAPK Is a Therapeutic Target for Triple-Negative Breast Cancer by Stimulation of Cancer Stem-Like Cell Expansion. (Qi X, Yin N, Ma S, Lepp A, Tang J, Jing W, Johnson B, Dwinell MB, Chitambar CR, Chen G) Stem Cells 2015 Sep;33(9):2738-47 PMID: 26077647 PMCID: PMC4792188 SCOPUS ID: 2-s2.0-84940467357 06/17/2015       18 Citations
  • p38γ MAPK is required for inflammation-associated colon tumorigenesis. (Yin N, Qi X, Tsai S, Lu Y, Basir Z, Oshima K, Thomas JP, Myers CR, Stoner G, Chen G) Oncogene 2016 Feb 25;35(8):1039-48 PMID: 25961922 SCOPUS ID: 2-s2.0-84959509513 05/12/2015       16 Citations
  • Identification of a ternary protein-complex as a therapeutic target for K-Ras-dependent colon cancer. (Qi X, Xie C, Hou S, Li G, Yin N, Dong L, Lepp A, Chesnik MA, Mirza SP, Szabo A, Tsai S, Basir Z, Wu S, Chen G) Oncotarget 2014 Jun 30;5(12):4269-82 PMID: 24962213 PMCID: PMC4147322 SCOPUS ID: 2-s2.0-84905098265 06/26/2014       11 Citations
  • MK2 Regulates Ras Oncogenesis through Stimulating ROS Production. (Kobayashi Y, Qi X, Chen G) Genes Cancer 2012 Jul;3(7-8):521-30 PMID: 23264852 PMCID: PMC3527985 12/25/2012    
  • p38γ Mitogen-activated protein kinase signals through phosphorylating its phosphatase PTPH1 in regulating ras protein oncogenesis and stress response. (Hou S, Suresh PS, Qi X, Lepp A, Mirza SP, Chen G) J Biol Chem 2012 Aug 10;287(33):27895-905 PMID: 22730326 PMCID: PMC3431700 SCOPUS ID: 2-s2.0-84865009345 06/26/2012       15 Citations
  • p38γ mitogen-activated protein kinase (MAPK) confers breast cancer hormone sensitivity by switching estrogen receptor (ER) signaling from classical to nonclassical pathway via stimulating ER phosphorylation and c-Jun transcription. (Qi X, Zhi H, Lepp A, Wang P, Huang J, Basir Z, Chitambar CR, Myers CR, Chen G) J Biol Chem 2012 Apr 27;287(18):14681-91 PMID: 22399296 PMCID: PMC3340246 SCOPUS ID: 2-s2.0-84860370781 03/09/2012       20 Citations
  • PTPH1 dephosphorylates and cooperates with p38gamma MAPK to increase ras oncogenesis through PDZ-mediated interaction. (Hou SW, Zhi HY, Pohl N, Loesch M, Qi XM, Li RS, Basir Z, Chen G) Cancer Res 2010 Apr 01;70(7):2901-10 PMID: 20332238 PMCID: PMC2848905 SCOPUS ID: 2-s2.0-77950794747 03/25/2010       52 Citations
  • p38gamma MAPK cooperates with c-Jun in trans-activating matrix metalloproteinase 9. (Loesch M, Zhi HY, Hou SW, Qi XM, Li RS, Basir Z, Iftner T, Cuenda A, Chen G) J Biol Chem 2010 May 14;285(20):15149-58 PMID: 20231272 PMCID: PMC2865276 SCOPUS ID: 2-s2.0-77952058710 03/17/2010       64 Citations
  • p38alpha antagonizes p38gamma activity through c-Jun-dependent ubiquitin-proteasome pathways in regulating Ras transformation and stress response. (Qi X, Pohl NM, Loesch M, Hou S, Li R, Qin JZ, Cuenda A, Chen G) J Biol Chem 2007 Oct 26;282(43):31398-408 PMID: 17724032 SCOPUS ID: 2-s2.0-35748932065 08/29/2007       42 Citations
  • Stress-induced c-Jun-dependent Vitamin D receptor (VDR) activation dissects the non-classical VDR pathway from the classical VDR activity. (Li QP, Qi X, Pramanik R, Pohl NM, Loesch M, Chen G) J Biol Chem 2007 Jan 19;282(3):1544-51 PMID: 17121851 SCOPUS ID: 2-s2.0-33847265408 11/24/2006       22 Citations
  • p38gamma mitogen-activated protein kinase integrates signaling crosstalk between Ras and estrogen receptor to increase breast cancer invasion. (Qi X, Tang J, Loesch M, Pohl N, Alkan S, Chen G) Cancer Res 2006 Aug 01;66(15):7540-7 PMID: 16885352 PMCID: PMC2174269 SCOPUS ID: 2-s2.0-33747872178 08/04/2006       32 Citations
  • Essential role of p38gamma in K-Ras transformation independent of phosphorylation. (Tang J, Qi X, Mercola D, Han J, Chen G) J Biol Chem 2005 Jun 24;280(25):23910-7 PMID: 15851477 PMCID: PMC1224721 SCOPUS ID: 2-s2.0-21244490119 04/27/2005       47 Citations
  • p38 MAPK activation selectively induces cell death in K-ras-mutated human colon cancer cells through regulation of vitamin D receptor. (Qi X, Tang J, Pramanik R, Schultz RM, Shirasawa S, Sasazuki T, Han J, Chen G) J Biol Chem 2004 May 21;279(21):22138-44 PMID: 15037631 SCOPUS ID: 2-s2.0-2542458262 03/24/2004       52 Citations
  • Estrogen receptor inhibits c-Jun-dependent stress-induced cell death by binding and modifying c-Jun activity in human breast cancer cells. (Qi X, Borowicz S, Pramanik R, Schultz RM, Han J, Chen G) J Biol Chem 2004 Feb 20;279(8):6769-77 PMID: 14638681 SCOPUS ID: 2-s2.0-1342325421 11/26/2003       26 Citations
  • p38 isoforms have opposite effects on AP-1-dependent transcription through regulation of c-Jun. The determinant roles of the isoforms in the p38 MAPK signal specificity. (Pramanik R, Qi X, Borowicz S, Choubey D, Schultz RM, Han J, Chen G) J Biol Chem 2003 Feb 14;278(7):4831-9 PMID: 12475989 SCOPUS ID: 2-s2.0-0038363324 12/12/2002       122 Citations
  • The p38 and JNK pathways cooperate to trans-activate vitamin D receptor via c-Jun/AP-1 and sensitize human breast cancer cells to vitamin D(3)-induced growth inhibition. (Qi X, Pramanik R, Wang J, Schultz RM, Maitra RK, Han J, DeLuca HF, Chen G) J Biol Chem 2002 Jul 19;277(29):25884-92 PMID: 11983707 SCOPUS ID: 2-s2.0-0037135524 05/02/2002       87 Citations
  • Last update: 07/31/2020
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