Medical College of Wisconsin
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Xiao Chen PhD, MD

Xiao Chen PhD, MD profile photo picture

Associate Professor

Institution: Medical College of Wisconsin
Department: Medicine
Division: Medicine Hematology Oncology

Member of the Cancer Center
Member of the Center for Immunology
Member of the Center for Microbiome Research

View Curriculum Vitae

Publications (32)

  • From support to therapy: rethinking the role of nutrition in acute graft-versus-host disease. (Limpert R, Pan P, Wang LS, Chen X) Front Immunol 2023;14:1192084 PMID: 37359550 PMCID: PMC10285162 SCOPUS ID: 2-s2.0-85162622656 06/26/2023       9 Citations
  • S1P/S1PR1 signaling differentially regulates the allogeneic response of CD4 and CD8 T cells by modulating mitochondrial fission. (Tian L, Wu Y, Choi HJ, Sui X, Li X, Sofi MH, Kassir MF, Chen X, Mehrotra S, Ogretmen B, Yu XZ) Cell Mol Immunol 2022 Nov;19(11):1235-1250 PMID: 36071219 PMCID: PMC9622814 SCOPUS ID: 2-s2.0-85137418710 09/08/2022       31 Citations
  • A Pilot Clinical Study to Investigate the Hypomethylating Properties of Freeze-dried Black Raspberries in Patients with Myelodysplastic Syndrome or Myeloproliferative Neoplasm. (Dong A, Pan X, Lin CW, Huang YW, Krause H, Pan P, Baim A, Thomas MJ, Chen X, Yu J, Michaelis L, Liu P, Wang LS, Atallah E) J Cancer Prev 2022 Jun 30;27(2):129-138 PMID: 35864858 PMCID: PMC9271408 07/23/2022    
  • Protocatechuic Acid, a Gut Bacterial Metabolite of Black Raspberries, Inhibits Adenoma Development and Alters Gut Microbiome Profiles in Apc Min/+ Mice. (Dong A, Lin CW, Echeveste CE, Huang YW, Oshima K, Yearsley M, Chen X, Yu J, Wang LS) J Cancer Prev 2022 Mar 30;27(1):50-57 PMID: 35419306 PMCID: PMC8984655 04/15/2022    
  • Dietary supplementation with black raspberries prolongs survival in ApcMin/+ mice. (Dong A, Huang YW, Yearsley M, Oshima K, Chen X, Yu J, Wang LS) Food Front 2021 Sep;2(3):324-328 PMID: 35360278 PMCID: PMC8963127 SCOPUS ID: 2-s2.0-85128927136 04/02/2022       7 Citations
  • Retinoic Acid Signaling Modulates Recipient Gut Barrier Integrity and Microbiota After Allogeneic Hematopoietic Stem Cell Transplantation in Mice. (Pan P, Atkinson SN, Taylor B, Zhu H, Zhou D, Flejsierowicz P, Wang LS, Morse M, Liu C, Gunsolus IL, Chen X) Front Immunol 2021;12:749002 PMID: 34759928 PMCID: PMC8573259 SCOPUS ID: 2-s2.0-85118722452 11/12/2021       11 Citations
  • Kras-Deficient T Cells Attenuate Graft-versus-Host Disease but Retain Graft-versus-Leukemia Activity. (Luo L, Chen Y, Chen X, Zheng Y, Zhou V, Yu M, Burns R, Zhu W, Fu G, Felix JC, Hartley C, Damnernsawad A, Zhang J, Wen R, Drobyski WR, Gao C, Wang D) J Immunol 2020 Dec 15;205(12):3480-3490 PMID: 33158956 PMCID: PMC7955895 SCOPUS ID: 2-s2.0-85097490484 11/08/2020       6 Citations
  • Nuclear Receptors as Potential Therapeutic Targets for Myeloid Leukemia. (Pan P, Chen X) Cells 2020 Aug 19;9(9) PMID: 32824945 PMCID: PMC7563802 SCOPUS ID: 2-s2.0-85089806628 08/23/2020       16 Citations
  • All trans-retinoic acid protects against acute ischemic stroke by modulating neutrophil functions through STAT1 signaling. (Cai W, Wang J, Hu M, Chen X, Lu Z, Bellanti JA, Zheng SG) J Neuroinflammation 2019 Aug 31;16(1):175 PMID: 31472680 PMCID: PMC6717357 SCOPUS ID: 2-s2.0-85071686674 09/02/2019       83 Citations
  • Radiation and host retinoic acid signaling promote the induction of gut-homing donor T cells after allogeneic hematopoietic stem cell transplantation. (Zheng J, Taylor B, Dodge J, Stephans A, Zheng SG, Chen Q, Chen X) Am J Transplant 2020 Jan;20(1):64-74 PMID: 31207088 PMCID: PMC6918002 SCOPUS ID: 2-s2.0-85069712148 06/18/2019       3 Citations
  • The Role of Micronutrients in Graft-VS.-Host Disease: Immunomodulatory Effects of Vitamins A and D. (Chen X, Mayne CG) Front Immunol 2018;9:2853 PMID: 30574143 PMCID: PMC6291446 SCOPUS ID: 2-s2.0-85058870758 12/24/2018       11 Citations
  • Role of Vitamin A in Modulating Graft-versus-Host Disease. (Zheng J, Taylor B, Chen X) J Immunol Res Ther 2018;3(1):124-128 PMID: 30101210 PMCID: PMC6086377 08/14/2018    
  • Loss of FFAR2 promotes colon cancer by epigenetic dysregulation of inflammation suppressors. (Pan P, Oshima K, Huang YW, Agle KA, Drobyski WR, Chen X, Zhang J, Yearsley MM, Yu J, Wang LS) Int J Cancer 2018 Aug 15;143(4):886-896 PMID: 29524208 PMCID: PMC6041131 SCOPUS ID: 2-s2.0-85044521158 03/11/2018       78 Citations
  • Loss of free fatty acid receptor 2 enhances colonic adenoma development and reduces the chemopreventive effects of black raspberries in ApcMin/+ mice. (Pan P, W Skaer C, Wang HT, Oshima K, Huang YW, Yu J, Zhang J, M Yearsley M, A Agle K, R Drobyski W, Chen X, Wang LS) Carcinogenesis 2017 Jan;38(1):86-93 PMID: 27866157 PMCID: PMC5219051 SCOPUS ID: 2-s2.0-85027864388 11/21/2016       42 Citations
  • Effects of Donor Vitamin A Deficiency and Pharmacologic Modulation of Donor T Cell Retinoic Acid Pathway on the Severity of Experimental Graft-versus-Host Disease. (Dodge J, Stephans A, Lai J, Drobyski WR, Chen X) Biol Blood Marrow Transplant 2016 Dec;22(12):2141-2148 PMID: 27596131 SCOPUS ID: 2-s2.0-85003032776 09/07/2016       8 Citations
  • A colitogenic memory CD4+ T cell population mediates gastrointestinal graft-versus-host disease. (Zhou V, Agle K, Chen X, Beres A, Komorowski R, Belle L, Taylor C, Zhu F, Haribhai D, Williams CB, Verbsky J, Blumenschein W, Sadekova S, Bowman E, Ballantyne C, Weaver C, Serody DA, Vincent B, Serody J, Cua DJ, Drobyski WR) J Clin Invest 2016 Sep 01;126(9):3541-55 PMID: 27500496 PMCID: PMC5004941 SCOPUS ID: 2-s2.0-84987784902 08/09/2016       27 Citations
  • Role of Th17 Cells and Interleukin 17 in Graft-versus-host Disease and Graft-versus-leukemia Reactivity (Chen X, Drobyski WR) Immune Biology of Allogeneic Hematopoietic Stem Cell Transplantation 2013:271-297 SCOPUS ID: 2-s2.0-84882596384 08/27/2013    
  • A critical role for the retinoic acid signaling pathway in the pathophysiology of gastrointestinal graft-versus-host disease. (Chen X, Dodge J, Komorowski R, Drobyski WR) Blood 2013 May 09;121(19):3970-80 PMID: 23529927 PMCID: PMC3650708 SCOPUS ID: 2-s2.0-84880458648 03/27/2013       27 Citations
  • Role of Th17 cells and interleukin 17 in graft-versus-host disease and graft-versus-leukemia reactivity (Chen X, Drobyski WR) Immune Biology of Allogeneic Hematopoietic Stem Cell Transplantation Models in Discovery and Translation 6 December 2012:271-297 SCOPUS ID: 2-s2.0-85135549834 12/06/2012    
  • Phosphatidylserine inhibits NFκB and p38 MAPK activation in human monocyte derived dendritic cells. (Doffek K, Chen X, Sugg SL, Shilyansky J) Mol Immunol 2011 Sep;48(15-16):1771-7 PMID: 21628073 SCOPUS ID: 2-s2.0-80051920498 06/02/2011       21 Citations
  • Interleukin 17 is not required for autoimmune-mediated pathologic damage during chronic graft-versus-host disease. (Chen X, Das R, Komorowski R, van Snick J, Uyttenhove C, Drobyski WR) Biol Blood Marrow Transplant 2010 Jan;16(1):123-8 PMID: 19772944 PMCID: PMC2804961 SCOPUS ID: 2-s2.0-72649088089 09/24/2009       15 Citations
  • Blockade of interleukin-6 signaling augments regulatory T-cell reconstitution and attenuates the severity of graft-versus-host disease. (Chen X, Das R, Komorowski R, Beres A, Hessner MJ, Mihara M, Drobyski WR) Blood 2009 Jul 23;114(4):891-900 PMID: 19491393 PMCID: PMC2716024 SCOPUS ID: 2-s2.0-68249160054 06/06/2009       264 Citations
  • Interleukin-23 secretion by donor antigen-presenting cells is critical for organ-specific pathology in graft-versus-host disease. (Das R, Chen X, Komorowski R, Hessner MJ, Drobyski WR) Blood 2009 Mar 05;113(10):2352-62 PMID: 19059877 PMCID: PMC2652376 SCOPUS ID: 2-s2.0-63849105635 12/09/2008       71 Citations
  • Absence of regulatory T-cell control of TH1 and TH17 cells is responsible for the autoimmune-mediated pathology in chronic graft-versus-host disease. (Chen X, Vodanovic-Jankovic S, Johnson B, Keller M, Komorowski R, Drobyski WR) Blood 2007 Nov 15;110(10):3804-13 PMID: 17693581 PMCID: PMC2077325 SCOPUS ID: 2-s2.0-36348980530 08/19/2007       214 Citations
  • Homeostatic expansion and repertoire regeneration of donor T cells during graft versus host disease is constrained by the host environment. (Gorski J, Chen X, Gendelman M, Yassai M, Krueger A, Tivol E, Logan B, Komorowski R, Vodanovic-Jankovic S, Drobyski WR) Blood 2007 Jun 15;109(12):5502-10 PMID: 17347406 PMCID: PMC1890817 SCOPUS ID: 2-s2.0-34249979259 03/10/2007       16 Citations
  • In-vivo generation of leukaemia-derived dendritic cells. (Kolb HJ, Rank A, Chen X, Woiciechowsky A, Roskrow M, Schmid C, Tischer J, Ledderose G) Best Pract Res Clin Haematol 2004 Sep;17(3):439-51 PMID: 15498715 SCOPUS ID: 2-s2.0-7744226324 10/23/2004       18 Citations
  • Phosphatidylserine regulates the maturation of human dendritic cells. (Chen X, Doffek K, Sugg SL, Shilyansky J) J Immunol 2004 Sep 01;173(5):2985-94 PMID: 15322157 SCOPUS ID: 2-s2.0-4344597636 08/24/2004       97 Citations
  • Adoptive immunotherapy in chimeras with donor lymphocytes. (Kolb HJ, Schmid C, Chen X, Woiciechowski A, Roskrow M, Weber M, Guenther W, Ledderose G, Schleuning M) Acta Haematol 2003;110(2-3):110-20 PMID: 14583671 SCOPUS ID: 2-s2.0-0242268023 10/30/2003       18 Citations
  • Neuroblastoma cells inhibit the immunostimulatory function of dendritic cells. (Chen X, Doffek K, Sugg SL, Shilyansky J) J Pediatr Surg 2003 Jun;38(6):901-5 PMID: 12778389 SCOPUS ID: 2-s2.0-0038657982 06/05/2003       10 Citations
  • Ex vivo generation of cytotoxic T lymphocytes specific for one or two distinct viruses for the prophylaxis of patients receiving an allogeneic bone marrow transplant. (Regn S, Raffegerst S, Chen X, Schendel D, Kolb HJ, Roskrow M) Bone Marrow Transplant 2001 Jan;27(1):53-64 PMID: 11244438 SCOPUS ID: 2-s2.0-0035141371 03/13/2001       47 Citations
  • Interferon alpha in combination with GM-CSF induces the differentiation of leukaemic antigen-presenting cells that have the capacity to stimulate a specific anti-leukaemic cytotoxic T-cell response from patients with chronic myeloid leukaemia. (Chen X, Regn S, Raffegerst S, Kolb HJ, Roskrow M) Br J Haematol 2000 Nov;111(2):596-607 PMID: 11122108 SCOPUS ID: 2-s2.0-0034533383 12/21/2000       59 Citations
  • Impaired expression of the CD3-zeta chain in peripheral blood T cells of patients with chronic myeloid leukaemia results in an increased susceptibility to apoptosis. (Chen X, Woiciechowsky A, Raffegerst S, Schendel D, Kolb HJ, Roskrow M) Br J Haematol 2000 Dec;111(3):817-25 PMID: 11122143 SCOPUS ID: 2-s2.0-0034494607 12/21/2000       55 Citations
    • Last update: 02/24/2025