Medical College of Wisconsin
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Yang Xiao

Assistant Professor

Institution: Medical College of Wisconsin
Department: Physiology

Member of the Cardiovascular Research Center

View Curriculum Vitae

Publications (22)

  • Integrative analyses elucidate transcriptional regulatory functions of risk alleles for metabolic liver disease. (Zhu B, He N, Xiao Y, Chen B, Li C, Mandla R, Liu Y, Zhang J, Chang X, Yu F, Vujkovic M, Lynch JA, Chang KM, VA Million Veteran Program, Pasaniuc B, Rader DJ, Lazar MA, Hu W) Nat Genet 2026 Jun;58(6):1280-1294 PMID: 42230773 SCOPUS ID: 2-s2.0-105041076315 06/03/2026    
  • Reduction in Hepatic Phosphatidylcholine Biosynthesis Promotes MASH Through Copper Deficiency. (Welles JE, Garifallou JP, Gonzalez MV, Santoleri D, Choudhury FK, DeNicola GM, Martin RW, Jiang C, Kim J, Li G, Aki Y, Chang CJ, Li D, Wells RG, Xiao Y, Zhang J, Lazar MA, Brady DC, Titchenell PM) bioRxiv 2026 May 14 PMID: 42182421 PMCID: PMC13192769 05/25/2026    
  • A non-apoptotic caspase-8-meteorin pathway in hepatocytes promotes MASH fibrosis. (Wang X, Moore MP, Shi H, Xiao Y, Zhang J, Faccioli LAP, Hu Z, Khalid S, Saleheen D, Stupack DG, Kisseleva T, Soto Gutierrez A, Lazar MA, Tabas I) Nat Metab 2025 Oct;7(10):2067-2082 PMID: 41006904 PMCID: PMC12552128 SCOPUS ID: 2-s2.0-105017400114 09/27/2025       8 Citations
  • An intrinsically disordered region controlling condensation of a circadian clock component and rhythmic transcription in the liver. (Zhu K, Celwyn IJ, Guan D, Xiao Y, Wang X, Hu W, Jiang C, Cheng L, Casellas R, Lazar MA) Mol Cell 2023 Oct 05;83(19):3457-3469.e7 PMID: 37802023 PMCID: PMC10575687 SCOPUS ID: 2-s2.0-85172194127 10/07/2023       29 Citations
  • Hepatocyte SREBP signaling mediates clock communication within the liver. (Guan D, Bae H, Zhou D, Chen Y, Jiang C, La CM, Xiao Y, Zhu K, Hu W, Trinh TM, Liu P, Xiong Y, Cai B, Jang C, Lazar MA) J Clin Invest 2023 Apr 17;133(8) PMID: 37066875 PMCID: PMC10104893 SCOPUS ID: 2-s2.0-85152629595 04/18/2023       29 Citations
  • RIP140 deficiency enhances cardiac fuel metabolism and protects mice from heart failure. (Yamamoto T, Maurya SK, Pruzinsky E, Batmanov K, Xiao Y, Sulon SM, Sakamoto T, Wang Y, Lai L, McDaid KS, Shewale SV, Leone TC, Koves TR, Muoio DM, Dierickx P, Lazar MA, Lewandowski ED, Kelly DP) J Clin Invest 2023 May 01;133(9) PMID: 36927960 PMCID: PMC10145947 SCOPUS ID: 2-s2.0-85159242651 03/18/2023       20 Citations
  • Hepatocytes demarcated by EphB2 contribute to the progression of nonalcoholic steatohepatitis. (Xiao Y, Batmanov K, Hu W, Zhu K, Tom AY, Guan D, Jiang C, Cheng L, McCright SJ, Yang EC, Lanza MR, Liu Y, Hill DA, Lazar MA) Sci Transl Med 2023 Feb 08;15(682):eadc9653 PMID: 36753562 PMCID: PMC10234568 SCOPUS ID: 2-s2.0-85147723227 02/09/2023       55 Citations
  • Isoform-specific functions of PPARγ in gene regulation and metabolism. (Hu W, Jiang C, Kim M, Xiao Y, Richter HJ, Guan D, Zhu K, Krusen BM, Roberts AN, Miller J, Steger DJ, Lazar MA) Genes Dev 2022 Mar 01;36(5-6):300-312 PMID: 35273075 PMCID: PMC8973844 SCOPUS ID: 2-s2.0-85127852299 03/12/2022       49 Citations
  • Circadian REV-ERBs repress E4bp4 to activate NAMPT-dependent NAD+ biosynthesis and sustain cardiac function. (Dierickx P, Zhu K, Carpenter BJ, Jiang C, Vermunt MW, Xiao Y, Luongo TS, Yamamoto T, Martí-Pàmies Í, Mia S, Latimer M, Diwan A, Zhao J, Hauck AK, Krusen B, Nguyen HCB, Blobel GA, Kelly DP, Pei L, Baur JA, Young ME, Lazar MA) Nat Cardiovasc Res 2022 Jan;1(1):45-58 PMID: 35036997 PMCID: PMC8754391 SCOPUS ID: 2-s2.0-85135126993 01/18/2022       64 Citations
  • Individual-specific functional epigenomics reveals genetic determinants of adverse metabolic effects of glucocorticoids. (Hu W, Jiang C, Kim M, Yang W, Zhu K, Guan D, Lv W, Xiao Y, Wilson JR, Rader DJ, Pui CH, Relling MV, Lazar MA) Cell Metab 2021 Aug 03;33(8):1592-1609.e7 PMID: 34233159 PMCID: PMC8340270 SCOPUS ID: 2-s2.0-85111276882 07/08/2021       30 Citations
  • Nuclear receptors and transcriptional regulation in non-alcoholic fatty liver disease. (Xiao Y, Kim M, Lazar MA) Mol Metab 2021 Aug;50:101119 PMID: 33220489 PMCID: PMC8324695 SCOPUS ID: 2-s2.0-85097478750 11/22/2020       38 Citations
  • The hepatocyte clock and feeding control chronophysiology of multiple liver cell types. (Guan D, Xiong Y, Trinh TM, Xiao Y, Hu W, Jiang C, Dierickx P, Jang C, Rabinowitz JD, Lazar MA) Science 2020 Sep 11;369(6509):1388-1394 PMID: 32732282 PMCID: PMC7849028 SCOPUS ID: 2-s2.0-85090870608 08/01/2020       149 Citations
  • Dysregulated lncRNA-miRNA-mRNA Network Reveals Patient Survival-Associated Modules and RNA Binding Proteins in Invasive Breast Carcinoma. (Dong Y, Xiao Y, Shi Q, Jiang C) Front Genet 2019;10:1284 PMID: 32010179 PMCID: PMC6975227 SCOPUS ID: 2-s2.0-85078791789 02/06/2020       20 Citations
  • Hippo pathway deletion in adult resting cardiac fibroblasts initiates a cell state transition with spontaneous and self-sustaining fibrosis. (Xiao Y, Hill MC, Li L, Deshmukh V, Martin TJ, Wang J, Martin JF) Genes Dev 2019 Nov 01;33(21-22):1491-1505 PMID: 31558567 PMCID: PMC6824468 SCOPUS ID: 2-s2.0-85074446303 09/29/2019       125 Citations
  • Tet inactivation disrupts YY1 binding and long-range chromatin interactions during embryonic heart development. (Fang S, Li J, Xiao Y, Lee M, Guo L, Han W, Li T, Hill MC, Hong T, Mo W, Xu R, Zhang P, Wang F, Chang J, Zhou Y, Sun D, Martin JF, Huang Y) Nat Commun 2019 Sep 20;10(1):4297 PMID: 31541101 PMCID: PMC6754421 SCOPUS ID: 2-s2.0-85072523190 09/22/2019       74 Citations
  • Hippo Signaling Plays an Essential Role in Cell State Transitions during Cardiac Fibroblast Development. (Xiao Y, Hill MC, Zhang M, Martin TJ, Morikawa Y, Wang S, Moise AR, Wythe JD, Martin JF) Dev Cell 2018 Apr 23;45(2):153-169.e6 PMID: 29689192 PMCID: PMC5947860 SCOPUS ID: 2-s2.0-85045577248 04/25/2018       160 Citations
  • Dystrophin-glycoprotein complex sequesters Yap to inhibit cardiomyocyte proliferation. (Morikawa Y, Heallen T, Leach J, Xiao Y, Martin JF) Nature 2017 Jul 13;547(7662):227-231 PMID: 28581498 PMCID: PMC5528853 SCOPUS ID: 2-s2.0-85024396048 06/06/2017       250 Citations
  • Hippo/Yap Signaling in Cardiac Development and Regeneration. (Xiao Y, Leach J, Wang J, Martin JF) Curr Treat Options Cardiovasc Med 2016 Jun;18(6):38 PMID: 27040401 SCOPUS ID: 2-s2.0-84962662548 04/05/2016       51 Citations
  • Yap and Taz play a crucial role in neural crest-derived craniofacial development. (Wang J, Xiao Y, Hsu CW, Martinez-Traverso IM, Zhang M, Bai Y, Ishii M, Maxson RE, Olson EN, Dickinson ME, Wythe JD, Martin JF) Development 2016 Feb 01;143(3):504-15 PMID: 26718006 PMCID: PMC4760309 SCOPUS ID: 2-s2.0-84956605784 01/01/2016       77 Citations
  • Actin cytoskeletal remodeling with protrusion formation is essential for heart regeneration in Hippo-deficient mice. (Morikawa Y, Zhang M, Heallen T, Leach J, Tao G, Xiao Y, Bai Y, Li W, Willerson JT, Martin JF) Sci Signal 2015 May 05;8(375):ra41 PMID: 25943351 PMCID: PMC4442128 SCOPUS ID: 2-s2.0-84929089950 05/07/2015       192 Citations
  • Combined developmental toxicity of bisphenol A and genistein in micromass cultures of rat embryonic limb bud and midbrain cells. (Xiao Y, Liu R, Xing L, Xu Y, Shang L, Hao W) Toxicol In Vitro 2011 Feb;25(1):153-9 PMID: 21034807 SCOPUS ID: 2-s2.0-78650520794 11/03/2010       11 Citations
  • Embryotoxic and teratogenic effects of the combination of bisphenol A and genistein on in vitro cultured postimplantation rat embryos. (Xing L, Xu Y, Xiao Y, Shang L, Liu R, Wei X, Jiang J, Hao W) Toxicol Sci 2010 Jun;115(2):577-88 PMID: 20299547 SCOPUS ID: 2-s2.0-77954080840 03/20/2010       45 Citations
    • Last update: 09/07/2026