Medical College of Wisconsin
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Yaqiang Wang PhD, MS

Yaqiang Wang PhD, MS profile photo picture

Assistant Professor

Institution: Medical College of Wisconsin
Department: Biophysics

image of /images/ORCIDiD_icon16x16.png   https://orcid.org/0000-0002-6822-4778

Member of the Cancer Center
Member of the Cardiovascular Research Center


I am willing to collaborate on research projects.

View Curriculum Vitae

Research Areas of Interest

  • Drug Discovery
  • G-Quadruplexes
  • RNA
  • RNA Folding
  • RNA Recognition Motif
  • Ribonucleoproteins

    • Methodologies and Techniques

  • Cryoelectron Microscopy
  • Crystallography, X-Ray
  • Nuclear Magnetic Resonance, Biomolecular

    • MCW Program / Core Facilities

  • Interdisciplinary Program in the Biomedical Sciences

    • Publications (24)

  • NMR-Based Fragment Screening for RNA-Targeted Drug Discovery. (Petersen RJ, Wang Y) Molecules 2026 Mar 10;31(6) PMID: 41900017 PMCID: PMC13029659 SCOPUS ID: 2-s2.0-105034195786 03/28/2026    
  • HEXIM1 inter-monomer autoinhibition governs 7SK RNA binding specificity and P-TEFb inactivation. (Yang Y, Murrali MG, Galvan S, Wang Y, Stephen C, Ajjampore N, Wang X, Feigon J) Nat Commun 2026 Jan 15;17(1):1570 PMID: 41540012 PMCID: PMC12901311 SCOPUS ID: 2-s2.0-105029838243 01/16/2026       1 Citation
  • Structure of LARP7 Protein p65-telomerase RNA Complex in Telomerase Revealed by Cryo-EM and NMR. (Wang Y, He Y, Wang Y, Yang Y, Singh M, Eichhorn CD, Cheng X, Jiang YX, Zhou ZH, Feigon J) J Mol Biol 2023 Jun 01;435(11):168044 PMID: 37330293 PMCID: PMC10988774 SCOPUS ID: 2-s2.0-85164295756 06/18/2023       9 Citations
  • Structure of Tetrahymena telomerase-bound CST with polymerase α-primase. (He Y, Song H, Chan H, Liu B, Wang Y, Sušac L, Zhou ZH, Feigon J) Nature 2022 Aug;608(7924):813-818 PMID: 35831498 PMCID: PMC9728385 SCOPUS ID: 2-s2.0-85134297080 07/14/2022       33 Citations
  • Structure of active human telomerase with telomere shelterin protein TPP1. (Liu B, He Y, Wang Y, Song H, Zhou ZH, Feigon J) Nature 2022 Apr;604(7906):578-583 PMID: 35418675 PMCID: PMC9912816 SCOPUS ID: 2-s2.0-85128051944 04/15/2022       83 Citations
  • Mechanistic Investigation of Drug Supersaturation in the Presence of Polysorbates as Solubilizing Additives by Solution Nuclear Magnetic Resonance Spectroscopy. (Lu X, Li M, Arce FA, Ling J, Setiawan N, Wang Y, Shi X, Campbell HR, Nethercott MJ, Xu W, Munson EJ, Marsac PJ, Su Y) Mol Pharm 2021 Dec 06;18(12):4310-4321 PMID: 34761934 SCOPUS ID: 2-s2.0-85119479582 11/12/2021       7 Citations
  • Structures of telomerase at several steps of telomere repeat synthesis. (He Y, Wang Y, Liu B, Helmling C, Sušac L, Cheng R, Zhou ZH, Feigon J) Nature 2021 May;593(7859):454-459 PMID: 33981033 PMCID: PMC8857963 SCOPUS ID: 2-s2.0-85105801957 05/14/2021       58 Citations
  • A structurally conserved human and Tetrahymena telomerase catalytic core. (Wang Y, Gallagher-Jones M, Sušac L, Song H, Feigon J) Proc Natl Acad Sci U S A 2020 Dec 08;117(49):31078-31087 PMID: 33229538 PMCID: PMC7733840 SCOPUS ID: 2-s2.0-85097572983 11/25/2020       23 Citations
  • Structural Biology of Telomerase. (Wang Y, Sušac L, Feigon J) Cold Spring Harb Perspect Biol 2019 Dec 02;11(12) PMID: 31451513 PMCID: PMC6886448 SCOPUS ID: 2-s2.0-85075963456 08/28/2019       76 Citations
  • Structural basis of 7SK RNA 5'-γ-phosphate methylation and retention by MePCE. (Yang Y, Eichhorn CD, Wang Y, Cascio D, Feigon J) Nat Chem Biol 2019 Feb;15(2):132-140 PMID: 30559425 PMCID: PMC6339579 SCOPUS ID: 2-s2.0-85058844730 12/19/2018       34 Citations
  • Structure of Telomerase with Telomeric DNA. (Jiang J, Wang Y, Sušac L, Chan H, Basu R, Zhou ZH, Feigon J) Cell 2018 May 17;173(5):1179-1190.e13 PMID: 29775593 PMCID: PMC5995583 SCOPUS ID: 2-s2.0-85046691882 05/19/2018       127 Citations
  • Structural biology of telomerase and its interaction at telomeres. (Wang Y, Feigon J) Curr Opin Struct Biol 2017 Dec;47:77-87 PMID: 28732250 PMCID: PMC5564310 SCOPUS ID: 2-s2.0-85024400278 07/22/2017       26 Citations
  • Progress in Human and Tetrahymena Telomerase Structure Determination. (Chan H, Wang Y, Feigon J) Annu Rev Biophys 2017 May 22;46:199-225 PMID: 28301767 PMCID: PMC5508521 SCOPUS ID: 2-s2.0-85019686968 03/17/2017       40 Citations
  • Structural conservation in the template/pseudoknot domain of vertebrate telomerase RNA from teleost fish to human. (Wang Y, Yesselman JD, Zhang Q, Kang M, Feigon J) Proc Natl Acad Sci U S A 2016 Aug 30;113(35):E5125-34 PMID: 27531956 PMCID: PMC5024593 SCOPUS ID: 2-s2.0-84984710859 08/18/2016       26 Citations
  • Molecular mechanism of GTPase activation at the signal recognition particle (SRP) RNA distal end. (Shen K, Wang Y, Hwang Fu YH, Zhang Q, Feigon J, Shan SO) J Biol Chem 2013 Dec 20;288(51):36385-97 PMID: 24151069 PMCID: PMC3868752 SCOPUS ID: 2-s2.0-84890891983 10/24/2013       23 Citations
  • Disordered Protein Diffusion under Crowded Conditions. (Wang Y, Benton LA, Singh V, Pielak GJ) J Phys Chem Lett 2012 Sep 20;3(18):2703-2706 PMID: 23185649 PMCID: PMC3505085 SCOPUS ID: 2-s2.0-84866618652 11/28/2012       61 Citations
  • Macromolecular crowding and protein stability. (Wang Y, Sarkar M, Smith AE, Krois AS, Pielak GJ) J Am Chem Soc 2012 Oct 10;134(40):16614-8 PMID: 22954326 SCOPUS ID: 2-s2.0-84867377395 09/08/2012       313 Citations
  • Macromolecular crowding fails to fold a globular protein in cells. (Schlesinger AP, Wang Y, Tadeo X, Millet O, Pielak GJ) J Am Chem Soc 2011 Jun 01;133(21):8082-5 PMID: 21534566 PMCID: PMC3102155 SCOPUS ID: 2-s2.0-79957787217 05/04/2011       137 Citations
  • Protein crowding tunes protein stability. (Miklos AC, Sarkar M, Wang Y, Pielak GJ) J Am Chem Soc 2011 May 11;133(18):7116-20 PMID: 21506571 SCOPUS ID: 2-s2.0-79955698252 04/22/2011       268 Citations
  • Effects of proteins on protein diffusion. (Wang Y, Li C, Pielak GJ) J Am Chem Soc 2010 Jul 14;132(27):9392-7 PMID: 20560582 PMCID: PMC2898919 SCOPUS ID: 2-s2.0-77955686807 06/22/2010       249 Citations
  • Protein (19)F NMR in Escherichia coli. (Li C, Wang GF, Wang Y, Creager-Allen R, Lutz EA, Scronce H, Slade KM, Ruf RA, Mehl RA, Pielak GJ) J Am Chem Soc 2010 Jan 13;132(1):321-7 PMID: 20050707 PMCID: PMC2815348 SCOPUS ID: 2-s2.0-74849140345 01/07/2010       210 Citations
  • Translational and rotational diffusion of a small globular protein under crowded conditions. (Li C, Wang Y, Pielak GJ) J Phys Chem B 2009 Oct 08;113(40):13390-2 PMID: 19791823 PMCID: PMC2774775 SCOPUS ID: 2-s2.0-70349653922 10/02/2009       86 Citations
  • Cerebral metabolic changes in a depression-like rat model of chronic forced swimming studied by ex vivo high resolution 1H magnetic resonance spectroscopy. (Li CX, Wang Y, Gao H, Pan WJ, Xiang Y, Huang M, Lei H) Neurochem Res 2008 Nov;33(11):2342-9 PMID: 18473166 SCOPUS ID: 2-s2.0-52549113219 05/14/2008       47 Citations
  • Metabolic changes in rat prefrontal cortex and hippocampus induced by chronic morphine treatment studied ex vivo by high resolution 1H NMR spectroscopy. (Gao H, Xiang Y, Sun N, Zhu H, Wang Y, Liu M, Ma Y, Lei H) Neurochem Int 2007 Jan;50(2):386-94 PMID: 17074420 SCOPUS ID: 2-s2.0-33846215592 11/01/2006       69 Citations
    • Last update: 04/21/2026