Medical College of Wisconsin
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Yi-Guang Chen PhD

Yi-Guang Chen PhD profile photo picture

Associate Professor

Institution: Medical College of Wisconsin
Department: Pediatrics
Division: Endocrinology


Publications (55)

  • UBASH3A deficiency accelerates type 1 diabetes development and enhances salivary gland inflammation in NOD mice. (Chen YG, Ciecko AE, Khaja S, Grzybowski M, Geurts AM, Lieberman SM) Sci Rep 2020 Jul 21;10(1):12019 PMID: 32694640 PMCID: PMC7374577 SCOPUS ID: 2-s2.0-85088288172 07/23/2020    
  • The CD137 Ligand Is Important for Type 1 Diabetes Development but Dispensable for the Homeostasis of Disease-Suppressive CD137+ FOXP3+ Regulatory CD4 T Cells. (Foda BM, Ciecko AE, Serreze DV, Ridgway WM, Geurts AM, Chen YG) J Immunol 2020 Jun 01;204(11):2887-2899 PMID: 32295876 PMCID: PMC7296588 SCOPUS ID: 2-s2.0-85084888777 04/17/2020    
  • Beta Cell Dedifferentiation Induced by IRE1α Deletion Prevents Type 1 Diabetes. (Lee H, Lee YS, Harenda Q, Pietrzak S, Oktay HZ, Schreiber S, Liao Y, Sonthalia S, Ciecko AE, Chen YG, Keles S, Sridharan R, Engin F) Cell Metab 2020 Apr 07;31(4):822-836.e5 PMID: 32220307 PMCID: PMC7346095 SCOPUS ID: 2-s2.0-85082797476 03/30/2020       1 Citation
  • Interleukin-27 Is Essential for Type 1 Diabetes Development and Sjögren Syndrome-like Inflammation. (Ciecko AE, Foda B, Barr JY, Ramanathan S, Atkinson MA, Serreze DV, Geurts AM, Lieberman SM, Chen YG) Cell Rep 2019 12 03;29(10):3073-3086.e5 PMID: 31801074 PMCID: PMC6914223 SCOPUS ID: 2-s2.0-85075892781 12/05/2019       4 Citations
  • Soluble CD137 Ameliorates Acute Type 1 Diabetes by Inducing T Cell Anergy. (Itoh A, Ortiz L, Kachapati K, Wu Y, Adams D, Bednar K, Mukherjee S, Chougnet C, Mittler RS, Chen YG, Dolan L, Ridgway WM) Front Immunol 2019;10:2566 PMID: 31787971 PMCID: PMC6853870 SCOPUS ID: 2-s2.0-85075568372 12/04/2019       2 Citations
  • Position β57 of I-Ag7 controls early anti-insulin responses in NOD mice, linking an MHC susceptibility allele to type 1 diabetes onset. (Gioia L, Holt M, Costanzo A, Sharma S, Abe B, Kain L, Nakayama M, Wan X, Su A, Mathews C, Chen YG, Unanue E, Teyton L) Sci Immunol 2019 08 30;4(38) PMID: 31471352 PMCID: PMC6816460 SCOPUS ID: 2-s2.0-85071762036 09/01/2019       7 Citations
  • Combined congenic mapping and nuclease-based gene targeting for studying allele-specific effects of Tnfrsf9 within the Idd9.3 autoimmune diabetes locus. (Forsberg MH, Foda B, Serreze DV, Chen YG) Sci Rep 2019 03 13;9(1):4316 PMID: 30867509 PMCID: PMC6416332 SCOPUS ID: 2-s2.0-85062884116 03/15/2019       3 Citations
  • CD11c+ Cells Are Gatekeepers for Lymphocyte Trafficking to Infiltrated Islets During Type 1 Diabetes. (Sandor AM, Lindsay RS, Dyjack N, Whitesell JC, Rios C, Bradley BJ, Haskins K, Serreze DV, Geurts AM, Chen YG, Seibold MA, Jacobelli J, Friedman RS) Front Immunol 2019;10:99 PMID: 30766536 PMCID: PMC6365440 SCOPUS ID: 2-s2.0-85061573541 02/16/2019       3 Citations
  • Innate immune activity as a predictor of persistent insulin secretion and association with responsiveness to CTLA4-Ig treatment in recent-onset type 1 diabetes. (Cabrera SM, Engle S, Kaldunski M, Jia S, Geoffrey R, Simpson P, Szabo A, Speake C, Greenbaum CJ, Type 1 Diabetes TrialNet CTLA4-Ig (Abatacept) Study Group, Chen YG, Hessner MJ) Diabetologia 2018 11;61(11):2356-2370 PMID: 30167736 PMCID: PMC6182660 SCOPUS ID: 2-s2.0-85052798832 09/01/2018       6 Citations
  • A Hypermorphic Nfkbid Allele Contributes to Impaired Thymic Deletion of Autoreactive Diabetogenic CD8+ T Cells in NOD Mice. (Presa M, Racine JJ, Dwyer JR, Lamont DJ, Ratiu JJ, Sarsani VK, Chen YG, Geurts A, Schmitz I, Stearns T, Allocco J, Chapman HD, Serreze DV) J Immunol 2018 10 01;201(7):1907-1917 PMID: 30127089 PMCID: PMC6143397 SCOPUS ID: 2-s2.0-85053474331 08/22/2018       7 Citations
  • The Role of NOD Mice in Type 1 Diabetes Research: Lessons from the Past and Recommendations for the Future. (Chen YG, Mathews CE, Driver JP) Front Endocrinol (Lausanne) 2018;9:51 PMID: 29527189 PMCID: PMC5829040 03/13/2018    
  • Improved Murine MHC-Deficient HLA Transgenic NOD Mouse Models for Type 1 Diabetes Therapy Development. (Racine JJ, Stewart I, Ratiu J, Christianson G, Lowell E, Helm K, Allocco J, Maser RS, Chen YG, Lutz CM, Roopenian D, Schloss J, DiLorenzo TP, Serreze DV) Diabetes 2018 05;67(5):923-935 PMID: 29472249 PMCID: PMC5909999 SCOPUS ID: 2-s2.0-85046031203 02/24/2018       5 Citations
  • Modulation of the diet and gastrointestinal microbiota normalizes systemic inflammation and β-cell chemokine expression associated with autoimmune diabetes susceptibility. (Henschel AM, Cabrera SM, Kaldunski ML, Jia S, Geoffrey R, Roethle MF, Lam V, Chen YG, Wang X, Salzman NH, Hessner MJ) PLoS One 2018;13(1):e0190351 PMID: 29293587 PMCID: PMC5749787 SCOPUS ID: 2-s2.0-85039965631 01/03/2018       5 Citations
  • CD137 Plays Both Pathogenic and Protective Roles in Type 1 Diabetes Development in NOD Mice. (Forsberg MH, Ciecko AE, Bednar KJ, Itoh A, Kachapati K, Ridgway WM, Chen YG) J Immunol 2017 05 15;198(10):3857-3868 PMID: 28363905 PMCID: PMC5426805 SCOPUS ID: 2-s2.0-85019711824 04/02/2017       9 Citations
  • Interferon-γ Limits Diabetogenic CD8+ T-Cell Effector Responses in Type 1 Diabetes. (Driver JP, Racine JJ, Ye C, Lamont DJ, Newby BN, Leeth CM, Chapman HD, Brusko TM, Chen YG, Mathews CE, Serreze DV) Diabetes 2017 03;66(3):710-721 PMID: 27920091 PMCID: PMC5319715 SCOPUS ID: 2-s2.0-85019616155 12/07/2016       8 Citations
  • Congenic mapping identifies a novel Idd9 subregion regulating type 1 diabetes in NOD mice. (Lin B, Ciecko AE, MacKinney E, Serreze DV, Chen YG) Immunogenetics 2017 03;69(3):193-198 PMID: 27796442 PMCID: PMC5335865 SCOPUS ID: 2-s2.0-84992740822 11/01/2016       2 Citations
  • Interleukin-15-mediated inflammation promotes non-alcoholic fatty liver disease. (Cepero-Donates Y, Lacraz G, Ghobadi F, Rakotoarivelo V, Orkhis S, Mayhue M, Chen YG, Rola-Pleszczynski M, Menendez A, Ilangumaran S, Ramanathan S) Cytokine 2016 06;82:102-11 PMID: 26868085 SCOPUS ID: 2-s2.0-84956921610 02/13/2016       20 Citations
  • Repeated Activation of Lung Invariant NKT Cells Results in Chronic Obstructive Pulmonary Disease-Like Symptoms. (Tsao CC, Tsao PN, Chen YG, Chuang YH) PLoS One 2016;11(1):e0147710 PMID: 26811900 PMCID: PMC4727802 SCOPUS ID: 2-s2.0-84958567904 01/27/2016       9 Citations
  • Homeostasis of IL-15 dependent lymphocyte subsets in the liver. (Cepero-Donates Y, Rakotoarivelo V, Mayhue M, Ma A, Chen YG, Ramanathan S) Cytokine 2016 06;82:95-101 PMID: 26778709 PMCID: PMC5293139 SCOPUS ID: 2-s2.0-84952911477 01/19/2016       4 Citations
  • Blood-based signatures in type 1 diabetes. (Cabrera SM, Chen YG, Hagopian WA, Hessner MJ) Diabetologia 2016 Mar;59(3):414-25 PMID: 26699650 PMCID: PMC4744128 SCOPUS ID: 2-s2.0-84957427317 12/25/2015       22 Citations
  • Interleukin-1 antagonism moderates the inflammatory state associated with Type 1 diabetes during clinical trials conducted at disease onset. (Cabrera SM, Wang X, Chen YG, Jia S, Kaldunski ML, Greenbaum CJ, Type 1 Diabetes TrialNet Canakinumab Study Group, Mandrup-Poulsen T, AIDA Study Group, Hessner MJ) Eur J Immunol 2016 Apr;46(4):1030-46 PMID: 26692253 PMCID: PMC4828314 SCOPUS ID: 2-s2.0-84955291992 12/23/2015       30 Citations
  • The Presence and Preferential Activation of Regulatory T Cells Diminish Adoptive Transfer of Autoimmune Diabetes by Polyclonal Nonobese Diabetic (NOD) T Cell Effectors into NSG versus NOD-scid Mice. (Presa M, Chen YG, Grier AE, Leiter EH, Brehm MA, Greiner DL, Shultz LD, Serreze DV) J Immunol 2015 Oct 01;195(7):3011-9 PMID: 26283479 PMCID: PMC4575869 SCOPUS ID: 2-s2.0-84942436455 08/19/2015       5 Citations
  • Efficient CRISPR/Cas9-Mediated Genome Editing in Mice by Zygote Electroporation of Nuclease. (Qin W, Dion SL, Kutny PM, Zhang Y, Cheng AW, Jillette NL, Malhotra A, Geurts AM, Chen YG, Wang H) Genetics 2015 Jun;200(2):423-30 PMID: 25819794 PMCID: PMC4492369 SCOPUS ID: 2-s2.0-84931385060 03/31/2015       112 Citations
  • A locus on mouse chromosome 13 inversely regulates CD1d expression and the development of invariant natural killer T-cells. (Tsaih SW, Presa M, Khaja S, Ciecko AE, Serreze DV, Chen YG) Genes Immun 2015 Apr-May;16(3):221-30 PMID: 25654212 PMCID: PMC4409484 SCOPUS ID: 2-s2.0-84928582595 02/06/2015       2 Citations
  • Molecular signatures differentiate immune states in type 1 diabetic families. (Chen YG, Cabrera SM, Jia S, Kaldunski ML, Kramer J, Cheong S, Geoffrey R, Roethle MF, Woodliff JE, Greenbaum CJ, Wang X, Hessner MJ) Diabetes 2014 Nov;63(11):3960-73 PMID: 24760139 PMCID: PMC4207392 SCOPUS ID: 2-s2.0-84906086651 04/25/2014       38 Citations
  • Gene targeting in NOD mouse embryos using zinc-finger nucleases. (Chen YG, Forsberg MH, Khaja S, Ciecko AE, Hessner MJ, Geurts AM) Diabetes 2014 Jan;63(1):68-74 PMID: 23974926 PMCID: PMC3868049 08/27/2013    
  • Temporal induction of immunoregulatory processes coincides with age-dependent resistance to viral-induced type 1 diabetes. (Chen YG, Mordes JP, Blankenhorn EP, Kashmiri H, Kaldunski ML, Jia S, Geoffrey R, Wang X, Hessner MJ) Genes Immun 2013 Sep;14(6):387-400 PMID: 23739610 PMCID: PMC4027975 SCOPUS ID: 2-s2.0-84883880468 06/07/2013       9 Citations
  • Genetic control of murine invariant natural killer T cells maps to multiple type 1 diabetes regions. (Tsaih SW, Khaja S, Ciecko AE, MacKinney E, Chen YG) Genes Immun 2013 Sep;14(6):380-6 PMID: 23719031 PMCID: PMC3766462 SCOPUS ID: 2-s2.0-84883850847 05/31/2013       2 Citations
  • Induction of autoimmune diabetes in non-obese diabetic mice requires interleukin-21-dependent activation of autoreactive CD8⁺ T cells. (Chen XL, Bobbala D, Rodriguez GM, Mayhue M, Chen YG, Ilangumaran S, Ramanathan S) Clin Exp Immunol 2013 Aug;173(2):184-94 PMID: 23607664 PMCID: PMC3722919 SCOPUS ID: 2-s2.0-84880021592 04/24/2013       10 Citations
  • Biobreeding rat islets exhibit reduced antioxidative defense and N-acetyl cysteine treatment delays type 1 diabetes. (Bogdani M, Henschel AM, Kansra S, Fuller JM, Geoffrey R, Jia S, Kaldunski ML, Pavletich S, Prosser S, Chen YG, Lernmark A, Hessner MJ) J Endocrinol 2013 Feb;216(2):111-23 PMID: 23111281 PMCID: PMC4077722 SCOPUS ID: 2-s2.0-84874778734 11/01/2012       14 Citations
  • Interleukin-15 plays an essential role in the pathogenesis of autoimmune diabetes in the NOD mouse. (Bobbala D, Chen XL, Leblanc C, Mayhue M, Stankova J, Tanaka T, Chen YG, Ilangumaran S, Ramanathan S) Diabetologia 2012 Nov;55(11):3010-20 PMID: 22890824 SCOPUS ID: 2-s2.0-84867571600 08/15/2012       22 Citations
  • Subcongenic analyses reveal complex interactions between distal chromosome 4 genes controlling diabetogenic B cells and CD4 T cells in nonobese diabetic mice. (Stolp J, Chen YG, Cox SL, Henck V, Zhang W, Tsaih SW, Chapman H, Stearns T, Serreze DV, Silveira PA) J Immunol 2012 Aug 01;189(3):1406-17 PMID: 22732593 PMCID: PMC3401322 SCOPUS ID: 2-s2.0-84864150616 06/27/2012       11 Citations
  • Comparative genetics: synergizing human and NOD mouse studies for identifying genetic causation of type 1 diabetes. (Driver JP, Chen YG, Mathews CE) Rev Diabet Stud 2012;9(4):169-87 PMID: 23804259 PMCID: PMC3740689 SCOPUS ID: 2-s2.0-84879532718 01/01/2012       15 Citations
  • Erratum: Interleukin-15 plays an essential role in the pathogenesis of autoimmune diabetes in the NOD mouse (Diabetologia DOI: 10.1007/s00125-012-2675- 1) (Bobbala D, Chen XL, Leblanc C, Mayhue M, Stankova J, Tanaka T, Chen YG, Ilangumaran S, Ramanathan S) Diabetologia December 2012;55(12):3401 SCOPUS ID: 2-s2.0-85028093629 01/01/2012    
  • Genetic control of murine invariant natural killer T-cell development dynamically differs dependent on the examined tissue type. (Chen YG, Tsaih SW, Serreze DV) Genes Immun 2012 Feb;13(2):164-74 PMID: 21938016 PMCID: PMC3291802 SCOPUS ID: 2-s2.0-84857786403 09/23/2011       12 Citations
  • Testing the role of P2X7 receptors in the development of type 1 diabetes in nonobese diabetic mice. (Chen YG, Scheuplein F, Driver JP, Hewes AA, Reifsnyder PC, Leiter EH, Serreze DV) J Immunol 2011 Apr 01;186(7):4278-84 PMID: 21357538 PMCID: PMC3094905 SCOPUS ID: 2-s2.0-79955013490 03/02/2011       25 Citations
  • Unmasking genes in a type 1 diabetes-resistant mouse strain that enhances pathogenic CD8 T-cell responses. (Driver JP, Chen YG, Zhang W, Asrat S, Serreze DV) Diabetes 2011 Apr;60(4):1354-9 PMID: 21307079 PMCID: PMC3064110 SCOPUS ID: 2-s2.0-79953226996 02/11/2011       1 Citation
  • Mouse models for the study of autoimmune type 1 diabetes: a NOD to similarities and differences to human disease. (Driver JP, Serreze DV, Chen YG) Semin Immunopathol 2011 Jan;33(1):67-87 PMID: 20424843 SCOPUS ID: 2-s2.0-79251621206 04/29/2010       127 Citations
  • Invariant natural killer T-cell control of type 1 diabetes: a dendritic cell genetic decision of a silver bullet or Russian roulette. (Driver JP, Scheuplein F, Chen YG, Grier AE, Wilson SB, Serreze DV) Diabetes 2010 Feb;59(2):423-32 PMID: 19903740 PMCID: PMC2809954 SCOPUS ID: 2-s2.0-77449115674 11/12/2009       20 Citations
  • A recombinant heavy chain antibody approach blocks ART2 mediated deletion of an iNKT cell population that upon activation inhibits autoimmune diabetes. (Scheuplein F, Rissiek B, Driver JP, Chen YG, Koch-Nolte F, Serreze DV) J Autoimmun 2010 Mar;34(2):145-54 PMID: 19796917 PMCID: PMC2822066 SCOPUS ID: 2-s2.0-75349113325 10/03/2009       23 Citations
  • Idd9/11 genetic locus regulates diabetogenic activity of CD4 T-cells in nonobese diabetic (NOD) mice. (Chen YG, Scheuplein F, Osborne MA, Tsaih SW, Chapman HD, Serreze DV) Diabetes 2008 Dec;57(12):3273-80 PMID: 18776136 PMCID: PMC2584133 SCOPUS ID: 2-s2.0-58149358856 09/09/2008       17 Citations
  • Selective delivery of beta cell antigen to dendritic cells in vivo leads to deletion and tolerance of autoreactive CD8+ T cells in NOD mice. (Mukhopadhaya A, Hanafusa T, Jarchum I, Chen YG, Iwai Y, Serreze DV, Steinman RM, Tarbell KV, DiLorenzo TP) Proc Natl Acad Sci U S A 2008 Apr 29;105(17):6374-9 PMID: 18430797 PMCID: PMC2359791 SCOPUS ID: 2-s2.0-44049086242 04/24/2008       103 Citations
  • Subcongenic analysis of genetic basis for impaired development of invariant NKT cells in NOD mice. (Chen YG, Driver JP, Silveira PA, Serreze DV) Immunogenetics 2007 Sep;59(9):705-12 PMID: 17619875 SCOPUS ID: 2-s2.0-34548661992 07/11/2007       22 Citations
  • Cellular expression requirements for inhibition of type 1 diabetes by a dominantly protective major histocompatibility complex haplotype. (Chen YG, Silveira PA, Osborne MA, Chapman HD, Serreze DV) Diabetes 2007 Feb;56(2):424-30 PMID: 17259387 SCOPUS ID: 2-s2.0-33847028326 01/30/2007       11 Citations
  • Partial versus full allogeneic hemopoietic chimerization is a preferential means to inhibit type 1 diabetes as the latter induces generalized immunosuppression. (Serreze DV, Osborne MA, Chen YG, Chapman HD, Pearson T, Brehm MA, Greiner DL) J Immunol 2006 Nov 15;177(10):6675-84 PMID: 17082580 SCOPUS ID: 2-s2.0-33750818891 11/04/2006       22 Citations
  • CD38 is required for the peripheral survival of immunotolerogenic CD4+ invariant NK T cells in nonobese diabetic mice. (Chen YG, Chen J, Osborne MA, Chapman HD, Besra GS, Porcelli SA, Leiter EH, Wilson SB, Serreze DV) J Immunol 2006 Sep 01;177(5):2939-47 PMID: 16920929 SCOPUS ID: 2-s2.0-33747775837 08/22/2006       24 Citations
  • Targeted disruption of CD38 accelerates autoimmune diabetes in NOD/Lt mice by enhancing autoimmunity in an ADP-ribosyltransferase 2-dependent fashion. (Chen J, Chen YG, Reifsnyder PC, Schott WH, Lee CH, Osborne M, Scheuplein F, Haag F, Koch-Nolte F, Serreze DV, Leiter EH) J Immunol 2006 Apr 15;176(8):4590-9 PMID: 16585549 SCOPUS ID: 2-s2.0-33645796667 04/06/2006       39 Citations
  • Novel leptin receptor mutation in NOD/LtJ mice suppresses type 1 diabetes progression: II. Immunologic analysis. (Lee CH, Chen YG, Chen J, Reifsnyder PC, Serreze DV, Clare-Salzler M, Rodriguez M, Wasserfall C, Atkinson MA, Leiter EH) Diabetes 2006 Jan;55(1):171-8 PMID: 16380490 SCOPUS ID: 2-s2.0-33644781754 12/29/2005       27 Citations
  • Of mice and men: use of animal models to identify possible interventions for the prevention of autoimmune type 1 diabetes in humans. (Serreze DV, Chen YG) Trends Immunol 2005 Nov;26(11):603-7 PMID: 16140038 SCOPUS ID: 2-s2.0-28444484693 09/06/2005       20 Citations
  • Activated NKT cells inhibit autoimmune diabetes through tolerogenic recruitment of dendritic cells to pancreatic lymph nodes. (Chen YG, Choisy-Rossi CM, Holl TM, Chapman HD, Besra GS, Porcelli SA, Shaffer DJ, Roopenian D, Wilson SB, Serreze DV) J Immunol 2005 Feb 01;174(3):1196-204 PMID: 15661873 SCOPUS ID: 2-s2.0-19944431804 01/22/2005       116 Citations
  • Molecular cloning and sequencing of the human heme-regulated eukaryotic initiation factor 2 alpha (eIF-2 alpha) kinase from bone marrow culture. (Omasa T, Chen YG, Mantalaris A, Tsai YC, Wu JH) DNA Seq 2002 Jun;13(3):133-7 PMID: 12391722 SCOPUS ID: 2-s2.0-0036320052 10/24/2002       4 Citations
  • A cDNA from human bone marrow encoding a protein exhibiting homology to the ATP1gamma1/PLM/MAT8 family of transmembrane proteins. (Omasa T, Chen YG, Mantalaris A, Wu JH) Biochim Biophys Acta 2001 Jan 26;1517(2):307-10 PMID: 11342114 SCOPUS ID: 2-s2.0-0035951666 05/09/2001       2 Citations
  • Expression of mPer1 and mPer2, two mammalian clock genes, in murine bone marrow. (Chen YG, Mantalaris A, Bourne P, Keng P, Wu JH) Biochem Biophys Res Commun 2000 Sep 24;276(2):724-8 PMID: 11027538 SCOPUS ID: 2-s2.0-0034710791 10/12/2000       40 Citations
  • Preparation of Der p 1 specific monoclonal antibodies and use in a two-site-ELISA to detect Der p 1 allergen. (Chien TI, Chen YG, Chiang BL) J Microbiol Immunol Infect 2000 Jun;33(2):87-92 PMID: 10917877 SCOPUS ID: 2-s2.0-0033942242 08/05/2000       3 Citations
  • Characterization of monoclonal antibodies against hepatitis C virus nonstructural protein 3: different antigenic determinants from human B cells. (Ou-Yang P, Chiang BL, Hwang LH, Chen YG, Yang PM, Chi WK, Chen PJ, Chen DS) J Med Virol 1999 Apr;57(4):345-50 PMID: 10089044 SCOPUS ID: 2-s2.0-84984567059 03/24/1999       7 Citations
  • Last update: 07/30/2020
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