Medical College of Wisconsin
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Amy W. Hudson PhD

Amy W. Hudson PhD profile photo picture

Professor

Institution: Medical College of Wisconsin
Department: Microbiology and Immunology

Member of the Center for Immunology

Research Experience

  • Antigen Presentation
  • Exanthema Subitum
  • Genes, MHC Class I
  • Herpesvirus 6, Human
  • Herpesvirus 7, Human
  • insulin-responsive glucose transport
  • synaptic vesicle recycling
  • viral immune evasion
  • HHV-6
  • HHV-7
  • human CD45
  • membrane trafficking

    • Publications (26)

  • Inflammatory CD4/CD8 double-positive human T cells arise from reactive CD8 T cells and are sufficient to mediate GVHD pathology. (Hess NJ, Turicek DP, Riendeau J, McIlwain SJ, Contreras Guzman E, Nadiminti K, Hudson A, Callander NS, Skala MC, Gumperz JE, Hematti P, Capitini CM) Sci Adv 2023 Mar 24;9(12):eadf0567 PMID: 36961891 PMCID: PMC10038349 SCOPUS ID: 2-s2.0-85151044773 03/25/2023       6 Citations
  • Characterization of the HHV-6B U20 Immunoevasin. (Schneider CL, Whyte ML, Konrad SL, Hudson AW) J Virol 2023 Feb 28;97(2):e0189022 PMID: 36688652 PMCID: PMC9973003 SCOPUS ID: 2-s2.0-85149154460 01/24/2023    
  • Corrigendum: Structural Models for Roseolovirus U20 And U21: Non-Classical MHC-I Like Proteins From HHV-6A, HHV-6B, and HHV-7. (Weaver GC, Arya R, Schneider CL, Hudson AW, Stern LJ) Front Immunol 2022;13:936968 PMID: 35677042 PMCID: PMC9169504 SCOPUS ID: 2-s2.0-85131659986 06/10/2022    
  • Structural Models for Roseolovirus U20 And U21: Non-Classical MHC-I Like Proteins From HHV-6A, HHV-6B, and HHV-7. (Weaver GC, Arya R, Schneider CL, Hudson AW, Stern LJ) Front Immunol 2022;13:864898 PMID: 35444636 PMCID: PMC9013968 SCOPUS ID: 2-s2.0-85128490952 04/22/2022       4 Citations
  • iNKT cells coordinate immune pathways to enable engraftment in nonconditioned hosts. (Hess NJ, S Bharadwaj N, Bobeck EA, McDougal CE, Ma S, Sauer JD, Hudson AW, Gumperz JE) Life Sci Alliance 2021 Jul;4(7) PMID: 34112724 PMCID: PMC8200291 SCOPUS ID: 2-s2.0-85108045175 06/12/2021       3 Citations
  • The Roseoloviruses Downregulate the Protein Tyrosine Phosphatase PTPRC (CD45). (Whyte ML, Smith KA, Buchberger A, Berg Luecke L, Tjan LH, Mori Y, Gundry RL, Hudson AW) J Virol 2021 Jun 24;95(14):e0162820 PMID: 33952641 PMCID: PMC8223955 SCOPUS ID: 2-s2.0-85108871238 05/07/2021       6 Citations
  • Different Human Immune Lineage Compositions Are Generated in Non-Conditioned NBSGW Mice Depending on HSPC Source. (Hess NJ, Lindner PN, Vazquez J, Grindel S, Hudson AW, Stanic AK, Ikeda A, Hematti P, Gumperz JE) Front Immunol 2020;11:573406 PMID: 33193358 PMCID: PMC7604455 SCOPUS ID: 2-s2.0-85094894828 11/17/2020       18 Citations
  • Early T Cell Activation Metrics Predict Graft-versus-Host Disease in a Humanized Mouse Model of Hematopoietic Stem Cell Transplantation. (Hess NJ, Hudson AW, Hematti P, Gumperz JE) J Immunol 2020 Jul 01;205(1):272-281 PMID: 32444392 PMCID: PMC7329317 SCOPUS ID: 2-s2.0-85088373153 05/24/2020       11 Citations
  • HHV-7 U21 exploits Golgi quality control carriers to reroute class I MHC molecules to lysosomes. (Dirck AT, Whyte ML, Hudson AW) Mol Biol Cell 2020 Feb 01;31(3):196-208 PMID: 31851583 PMCID: PMC7001482 SCOPUS ID: 2-s2.0-85081146090 12/19/2019       5 Citations
  • Adoptively transferred Vγ9Vδ2 T cells show potent antitumor effects in a preclinical B cell lymphomagenesis model. (Zumwalde NA, Sharma A, Xu X, Ma S, Schneider CL, Romero-Masters JC, Hudson AW, Gendron-Fitzpatrick A, Kenney SC, Gumperz JE) JCI Insight 2017 Jul 06;2(13) PMID: 28679955 PMCID: PMC5499361 SCOPUS ID: 2-s2.0-85045321193 07/07/2017       51 Citations
  • Natural Killer Cell Evasion Is Essential for Infection by Rhesus Cytomegalovirus. (Sturgill ER, Malouli D, Hansen SG, Burwitz BJ, Seo S, Schneider CL, Womack JL, Verweij MC, Ventura AB, Bhusari A, Jeffries KM, Legasse AW, Axthelm MK, Hudson AW, Sacha JB, Picker LJ, Früh K) PLoS Pathog 2016 Aug;12(8):e1005868 PMID: 27580123 PMCID: PMC5006984 SCOPUS ID: 2-s2.0-84984830187 09/01/2016       29 Citations
  • Roseoloviruses and their modulation of host defenses. (Hudson AW) Curr Opin Virol 2014 Dec;9:178-87 PMID: 25462451 SCOPUS ID: 2-s2.0-84915759618 12/03/2014       12 Citations
  • Adaptor protein complexes AP-1 and AP-3 are required by the HHV-7 Immunoevasin U21 for rerouting of class I MHC molecules to the lysosomal compartment. (Kimpler LA, Glosson NL, Downs D, Gonyo P, May NA, Hudson AW) PLoS One 2014;9(6):e99139 PMID: 24901711 PMCID: PMC4047081 SCOPUS ID: 2-s2.0-84902477273 06/06/2014       4 Citations
  • Human herpesvirus 7 U21 tetramerizes to associate with class I major histocompatibility complex molecules. (May NA, Wang Q, Balbo A, Konrad SL, Buchli R, Hildebrand WH, Schuck P, Hudson AW) J Virol 2014 Mar;88(6):3298-308 PMID: 24390327 PMCID: PMC3957921 SCOPUS ID: 2-s2.0-84894543495 01/07/2014       14 Citations
  • Expression of CD1c enhances human invariant NKT cell activation by α-GalCer. (Fox LM, Miksanek J, May NA, Scharf L, Lockridge JL, Veerapen N, Besra GS, Adams EJ, Hudson AW, Gumperz JE) Cancer Immun 2013;13:9 PMID: 23885215 PMCID: PMC3721260 SCOPUS ID: 2-s2.0-84879033899 07/26/2013       11 Citations
  • The human herpesvirus-7 (HHV-7) U21 immunoevasin subverts NK-mediated cytoxicity through modulation of MICA and MICB. (Schneider CL, Hudson AW) PLoS Pathog 2011 Nov;7(11):e1002362 PMID: 22102813 PMCID: PMC3213103 SCOPUS ID: 2-s2.0-81755166703 11/22/2011       41 Citations
  • Insight into the mechanism of human herpesvirus 7 U21-mediated diversion of class I MHC molecules to lysosomes. (Glosson NL, Gonyo P, May NA, Schneider CL, Ristow LC, Wang Q, Hudson AW) J Biol Chem 2010 Nov 19;285(47):37016-29 PMID: 20833720 PMCID: PMC2978630 SCOPUS ID: 2-s2.0-78449233108 09/14/2010       12 Citations
  • Human herpesvirus 7 u21 downregulates classical and nonclassical class I major histocompatibility complex molecules from the cell surface. (May NA, Glosson NL, Hudson AW) J Virol 2010 Apr;84(8):3738-51 PMID: 20106916 PMCID: PMC2849505 SCOPUS ID: 2-s2.0-77950482035 01/29/2010       21 Citations
  • Human herpesvirus-6A and -6B encode viral immunoevasins that downregulate class I MHC molecules. (Glosson NL, Hudson AW) Virology 2007 Aug 15;365(1):125-35 PMID: 17467766 SCOPUS ID: 2-s2.0-34250165758 05/01/2007       52 Citations
  • Biochemical analysis of Angelman syndrome-associated mutations in the E3 ubiquitin ligase E6-associated protein. (Cooper EM, Hudson AW, Amos J, Wagstaff J, Howley PM) J Biol Chem 2004 Sep 24;279(39):41208-17 PMID: 15263005 SCOPUS ID: 2-s2.0-4644295494 07/21/2004       83 Citations
  • The ER-lumenal domain of the HHV-7 immunoevasin U21 directs class I MHC molecules to lysosomes. (Hudson AW, Blom D, Howley PM, Ploegh HL) Traffic 2003 Dec;4(12):824-37 PMID: 14617346 SCOPUS ID: 2-s2.0-0348013275 11/18/2003       29 Citations
  • The cell biology of antigen presentation. (Hudson AW, Ploegh HL) Exp Cell Res 2002 Jan 01;272(1):1-7 PMID: 11740859 SCOPUS ID: 2-s2.0-0036059818 12/13/2001       31 Citations
  • A human herpesvirus 7 glycoprotein, U21, diverts major histocompatibility complex class I molecules to lysosomes. (Hudson AW, Howley PM, Ploegh HL) J Virol 2001 Dec;75(24):12347-58 PMID: 11711625 PMCID: PMC116131 SCOPUS ID: 2-s2.0-0035201673 11/17/2001       52 Citations
  • Identification of a nonneuronal isoform of synaptotagmin. (Hudson AW, Birnbaum MJ) Proc Natl Acad Sci U S A 1995 Jun 20;92(13):5895-9 PMID: 7597049 PMCID: PMC41608 SCOPUS ID: 2-s2.0-0029036903 06/20/1995       77 Citations
  • Targeting of the "insulin-responsive" glucose transporter (GLUT4) to the regulated secretory pathway in PC12 cells. (Hudson AW, Fingar DC, Seidner GA, Griffiths G, Burke B, Birnbaum MJ) J Cell Biol 1993 Aug;122(3):579-88 PMID: 8335686 PMCID: PMC2119662 SCOPUS ID: 2-s2.0-0027184471 08/01/1993       60 Citations
  • Isoform-specific subcellular targeting of glucose transporters in mouse fibroblasts. (Hudson AW, Ruiz M, Birnbaum MJ) J Cell Biol 1992 Feb;116(3):785-97 PMID: 1309819 PMCID: PMC2289322 SCOPUS ID: 2-s2.0-0026596043 02/01/1992       92 Citations
    • Last update: 03/20/2024