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CURRICULUM VITAE

Andrey Sorokin PhD
Professor
Department of Medicine
Division of Nephrology

OFFICE ADDRESS:
Cardiovascular Research Center
8701 Watertown Plank Rd
Milwaukee, WI 53226

CITIZENSHIP:  USA

EDUCATION:
9/1972 - 8/1977 MS, St. Petersburg State University, St. Petersburg, Russia
9/1977 - 9/1980 PhD, Institute of Cytology of the Russian Academy of Sciences, St. Petersburg, Russia

POSTGRADUATE TRAINING AND FELLOWSHIP APPOINTMENTS:
10/1980 - 9/1985 Postdoctoral Fellow, Institute of Cytology of the Russian Academy of Sciences, St. Petersburg, Russia,
10/1985 - 3/1989 Scientist, Institute of Cytology of the Russian Academy of Sciences, St. Petersburg, Russia,

FACULTY APPOINTMENTS:
4/1989 - 10/1989 Visiting Scientist, Ludwig Institute for Cancer Research, Uppsala, Sweden,
11/1989 - 10/1990 Senior Scientist (Assistant Professor), Physiology of Cell Cycle Division, Institute of Cytology of the Russian Academy of Sciences, St. Petersburg, Russia,
11/1990 - 11/1994 Instructor, Department of Pharmacology, New York University Medical Center, New York, NY
12/1994 - 6/1995 Assistant Professor, Department of Medicine, Department of Physiology (secondary), Case Western Reserve University, Cleveland, OH
7/1995 - 6/2001 Assistant Professor, Department of Medicine/Nephrology, Department of Physiology (secondary), Medical College of Wisconsin, Milwaukee, WI
7/2001 - 7/2006 Associate Professor, Department of Medicine/NephrologyDepartment of Physiology (secondary), Medical College of Wisconsin, Milwaukee, WI
7/2004 - 7/2006 Associate Professor, Department of Microbiology and, Molecular Genetics (secondary), Medical College of Wisconsin, Milwaukee, WI
7/2006 - Present Professor , Department of Medicine/Nephrology, Department of Physiology (secondary), Department of Microbiology and Molecular Genetics (secondary), Medical College of Wisconsin, Milwaukee, WI

RESEARCH ADMINISTRATIVE APPOINTMENTS:
7/1995 - Present Director, Signal Transduction Research Laboratory, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226

AWARDS AND HONORS:
12/2005 - Present Certificate of Recognition as an Outstanding Researcher in the Division of Nephrology, Medical College of Wisconsin Division of Nephrology

MEMBERSHIPS IN HONORARY AND PROFESSIONAL SOCIETIES:
1/2001 - Present American Society of Nephrology (Member)
1/2002 - Present American Society for Biochemistry and Molecular Biology (Member)
8/2004 - Present Cell Death Society (Member)
1/2006 - Present International Society of Nephrology (Member)
1/2010 - Present American Society of Hypertension (Member)

EDITORSHIPS/EDITORIAL BOARDS/JOURNAL REVIEWS:
Editorial Board
9/2007 - 9/2008 Canadian Journal of Physiology and Pharmacology
4/2008 - Present Cell Health and Cytoskeleton
Journal Review
6/1996 - Present Hypertension
6/1996 - Present American Journal of Physiology
6/1996 - Present Journal of Virology
6/1996 - Present European Journal of Physiology
6/1996 - Present Journal of Pharmacology and Experimental Therapeutics
6/1996 - Present Fundamental & Clinical Pharmacology
6/1996 - Present Cellular Reprogramming
6/1996 - Present Comprehensive Physiology
6/1996 - Present Expert Opinion On Therapeutic Targets
6/1996 - Present Journal of Diabetes and Its Complications
6/1996 - Present Free Radical Biology & Medicine
6/1996 - Present Breast Cancer Research
6/1996 - Present European Journal of Neuroscience
6/1996 - Present Canadian Journal of Physiology and Pharmacology
6/1996 - Present Kidney International
6/1996 - Present Gastroenterology
6/1996 - Present International Journal of Cancer
6/1996 - Present Physiological Genomics
6/1996 - Present Brazilian Journal of Medical and Biological Research
6/1996 - Present The Journal of Clinical Investigation
6/1996 - Present Journal American Society of Nephrology
6/1996 - Present Protein Expression and Purification
6/1996 - Present Oncogene, Circulation Research
6/1996 - Present Biochemical Journal
6/1996 - Present European Journal of Pharmacology
6/1996 - Present Cellular Physiology and Biochemistry
2002 - Present Cancer Research Campaign, United Kingdom
2003 - Present R&D Office for the Health and Personal Social Services in Northern Ireland
2003 - Present The Royal Hospital Trust, United Kingdom
2003 - Present Health Research Board in Ireland (the main Ireland government agency for the support of health research)
2004 - Present Research Grants Council of Hong Kong
2006 - Present Research and Development Office, Recognized Research Group Call 2005, Northern Ireland, Belfast
2010 - Present MCW Cancer Center
2010 - Present Medical College of Wisconsin Clinical and Translational Science Institute
2010 - Present Medical Research Council, United Kingdom

NATIONAL ELECTED/APPOINTED LEADERSHIP AND COMMITTEE POSITIONS:
7/2000 - 6/2003 Member, National Cardiorenal Peer Review Committee, American Heart Study Section
1/2001 - 12/2001 Ad Hoc Reviewer, Department of Veteran Affairs, Nephrology Review Board
12/2003 - Present Reviewer of Intramural Grant Proposals, Kansas University Medicine & Health Sciences
1/2004 - 12/2005 Member, Organizing committee for International Conference “Endothelin-9”, ET-9 Advisory Board
1/2004 - 7/2010 Abstract Grader, Growth Factors, Cytokines, Signal Transduction category , American Heart Association’s 2004-2011 Scientific Sessions
1/2005 - 10/2005 Abstract Reviewer, Ninth International Conference on Endothelin
1/2005 - 12/2005 Member, Local Organizing Committee, Ninth International Conference on Endothelin
3/2005 - 8/2005 Abstract Reviewer, Society for Free Radical Biology and Medicine
1/2007 - 8/2007 Member, National Cardiorenal Peer Review Committee, American Heart Study Section
1/2007 - Present Faculty Member, Pathophysiology of Chronic Kidney Disease section , Nephrology specialty at Faculty of 1000 Medicine
3/2008 - 9/2010 Abstract Reviewer, Annual Meeting of the Society for Free Radical Biology and Medicine (SFRBM)

RESEARCH GRANTS/AWARDS/CONTRACTS/PROJECTS:
Active
Peer Review
Title:
Cellular Regulation of Prostaglandin Synthesis
Source:
NIH RO1DK41684
Role:
Principal Investigator
PI:
Self
Dates:
2/15/2005 - 11/30/2011
Direct Funds:
$1,250,000
 
Title:
BK virus entry pathways and prevention of polyomavirus nephropathy after renal transplantation
Source:
Roche Organ Transplantation Research Foundation
Role:
Principal Investigator
PI:
Self
Dates:
9/1/2008 - 2/1/2013
Direct Funds:
$200,000
 
Title:
Pix and Sodium Readsorption
Source:
Midwest Affiliate American Heart Association Postdoctoral Fellowship (Pavlov)
Role:
Co-Sponsor
Dates:
7/1/2010 - 6/30/2012
Direct Funds:
$100,000
 
Title:
Adaptor protein p66 Shc and hypertension-induced nephropathy
Source:
Midwest Affiliate American Heart Association Predoctoral Fellowship (Alexanian)
Role:
Sponsor
Dates:
7/1/2010 - 6/30/2012
Direct Funds:
$52,000
 
Title:
Eicosanoids and resistance of prostate cancer cells to chemotherapeutic agents
Source:
Fraternal Order of Eagles
Role:
Principal Investigator
PI:
Self
Dates:
7/1/2010 - 6/30/2015
Direct Funds:
$10,000
 
Title:
Mitochondria-targeted Agents in Breast Cancer
Source:
NIH RO1CA152810-01 (Kalyanaraman)
Role:
Co-Investigator
Dates:
7/14/2010 - 4/30/2015
Direct Funds:
$1,250,000
 
Title:
Mitochondria-targeted Agents in Breast Cancer
Source:
NIH R01DK052448 (Raymond)
Role:
Co-Investigator
Dates:
10/1/2010 - 8/13/2013
Direct Funds:
$875,000
 
Title:
BK Virus Receptor and Polyomavirus Nephropathy
Source:
NIH R21DK088018-01
Role:
Principal Investigator
PI:
Self
Dates:
4/1/2011 - 3/31/2013
Direct Funds:
$275,000
 
Pending
Peer Review
Title:
Protein-protein interactions controlling Cox-2 function
Source:
Faculty Research Inducement Grant of the Biotechnology and Bioengineering Center
Role:
Principal Investigator
PI:
Self
Dates:
7/1/2005 - 6/30/2006
Direct Funds:
$13,000
 
Title:
New Paradigms for Breast Cancer Therapy Optimized with Advanced Imaging
Source:
National Cancer Institute (NCI)/NIH
Role:
Co-investigator, Projects 3 and 4
Dates:
7/1/2011 - 6/30/2016
Direct Funds:
$10,162,860 (Pending IRG review)
 
Title:
Role of p66 Shc in Hypertension Induced Renal Vascular Dysfunction
Source:
NIH RO1DK091279
Role:
Principal Investigator
PI:
Self
Dates:
4/1/2012 - 3/31/2017
Direct Funds:
$1,250,000 (Pending IRG review)
 
Title:
Cellular Regulation of Prostaglandin Synthesis
Source:
NIH RO1DK41684
Role:
Principal Investigator
PI:
Self
Dates:
7/1/2012 - 6/30/2017
Direct Funds:
$1,250,000 (in preparation for resubmission for November 5, 2011 deadline)
 
Prior
Peer Review
Title:
Eicosanoids & Platelet Activating Factor in Renal Injury
Source:
NIH (Dunn)
Role:
Co-Principal Investigator
Dates:
1994 - 1999
Direct Funds:
$675,145
 
Title:
Prostaglandins, The Kidney and Hypertension
Source:
NIH (Dunn)
Role:
Co-Principal Investigator
Dates:
1994 - 1999
Direct Funds:
$1,280,645
 
Title:
Molecular scanning of adaptor protein Crk gene in tumors
Source:
Milheim Foundation for Cancer Research Grant
Role:
Principal Investigator
PI:
Self
Dates:
7/1/1995 - 6/30/1996
Direct Funds:
$13,000
 
Title:
Non-isotopic single-strand conformation polymorphism (SSCP) analysis of adaptor protein Crk gene in cancer
Source:
New Investigator Award/American Cancer Society grant
Role:
Principal Investigator
PI:
Self
Dates:
7/1/1995 - 6/30/1996
Direct Funds:
$10,000
 
Title:
Molecular scanning of PGHS-2 promoter in colon tumors
Source:
New Interdisciplinary Research Project Grant Cancer Center, Medical College of Wisconsin
Role:
Principal Investigator
PI:
Self
Dates:
7/1/1998 - 6/30/1999
Direct Funds:
$25,000
 
Title:
Vascular Signaling by Free Radicals
Source:
NIH 1P01 HL 68769 (Harder)
Role:
Co-Investigator
Dates:
4/1/2002 - 3/31/2007
Direct Funds:
$1,023,495
 
Title:
Endothelin Signaling and Regulation of Protein Kinases
Source:
NIH 5R01HL022563
Role:
Principal Investigator
PI:
Self
Dates:
9/1/2003 - 8/30/2009
Direct Funds:
$1,747,250
 
Title:
Cellular and Molecular Mechanisms Regulating Nutritive Cerebral Blood Flow
Source:
NIH 1P01HL 59996 (Harder)
Role:
Co-Investigator
Dates:
12/1/2004 - 11/30/2009
Direct Funds:
$1,603,050
 
Title:
Role of Cdc42/Rac guanine nucleotide exchange factor in endothelin signaling in glomerular mesangial cells
Source:
American Heart, Greater Midwest Affiliate, 0520114Z, Postdoctoral Fellowship (applicant A. Chahdi)
Role:
Sponsor
Dates:
1/1/2005 - 12/31/2007
Direct Funds:
$110,000
 
Title:
Regulating Cerebrial Microcirculation by astrocytes
Source:
NIH R01 HL33833 (Harder)
Role:
Co-Investigator
Dates:
4/1/2005 - 3/31/2009
Direct Funds:
$1,400,000
 
Title:
Pyk2/Rap1 pathway in endothelin-1 signaling in renal mesangium
Source:
American Heart, Greater Midwest Affiliate, 0525801Z, Postdoctoral Fellowship (applicant V. Petrukhina)
Role:
Sponsor
Dates:
7/1/2005 - 6/30/2007
Direct Funds:
$104,000
 
Title:
Eicosanoids and resistance of prostate cancer cells to chemotherapeutic agents
Source:
Wisconsin Breast Cancer Showhouse
Role:
Principal Investigator
PI:
Self
Dates:
3/1/2009 - 2/27/2011
Direct Funds:
$132,000
 
Non-Peer Review
Title:
Cyclooxygenase-2 and apoptosis in prostate cancer
Source:
MCW Prostate Cancer Research Program
Role:
Principal Investigator
PI:
Self
Dates:
9/1/2001 - 8/30/2003
Direct Funds:
$100,000
 
Title:
Cardiovascular Research Center Fellowship In Hypertension
Source:
Department of Physiology, Medical College of Wisconsin
Role:
Sponsor (applicant Patel)
Dates:
12/1/2001 - 11/30/2002
Direct Funds:
$80,000
 
Title:
Caveolae-associated BK virus infection of kidney cells
Source:
Program Development Grant, Division Nephrology, Department of Medicine
Role:
Principal Investigator
PI:
Self
Dates:
7/1/2005 - 6/30/2007
Direct Funds:
$100,000
 
INVITED LECTURES/WORKSHOPS/PRESENTATIONS:
Local
1. Oligomerization and signaling by EGF and FGF receptor, Medical College of Wisconsin, Department of Physiology, Milwaukee, WI, 1995 - Present
2. Department of Physiology, Medical College of Wisconsin, Milwaukee, WI, 1997 - Present
3. Cardiovascular Center Research Seminar, Medical College of Wisconsin, Cardiovascular Research Center, Milwaukee, WI, 1998 - Present
4. Endothelin signaling via adaptor protein p66 Shc, MCW Cancer Center Signaling and Gene Expression Group, Milwaukee, WI, 2001 - Present
5. Protein tyrosine kinase Pyk2 mediates endothelin-induced p38 MAP kinase activation, MCW Cancer Center Signaling and Gene Expression Group, Milwaukee, WI, 2001 - Present
6. Cyclooxygenase 2, Nitric Oxide Synthase and Apoptosis, Medical College of Wisconsin, Department of Physiology, Milwaukee, WI, 2001 - Present
7. Endothelin signaling in glomerular mesangial cells, Department Physiology, Medical College of Wisconsin, Milwaukee, WI, 2002 - Present
8. Cyclooxygenase 2 and apoptosis in prostate cancer, MCW Cancer Center Prostate Cancer Research Group, Milwaukee, WI, 2002 - Present
9. The contributions of cyclooxygenase 2 to protection from cell death, Cardiovascular Research Center, Medical College of Wisconsin, Milwaukee, WI, 2002 - Present
10. Regulation of apoptosis by Cyclooxygenase-2, Nephrology Research Conference, Department , Medical College of Wisconsin , 2002 - Present
11. Pix, Pyk, Shc, Crk: Abracadabra of Endothelin signaling, Cardiovascular Research , Medical College of Wisconsin, Milwaukee, WI, 2003 - Present
12. Cyclooxygenase-2: potential role in regulation of drug efflux and multidrug resistance phenotype, Lecture at SAGE meeting, Medical College of Wisconsin, Milwaukee, WI, 2003 - Present
13. Endothelin signaling and regulation of apoptosis, Department of Microbiology and Molecular Genetics, Medical College of Wisconsin, Milwaukee, WI, 2004 - Present
14. Role of adaptor protein p66 Shc in endothelin signaling in renal mesangium, Research Conference, Division of Nephrology, Medical College of Wisconsin, 2004 - Present
15. Signaling pathways regulating endothelin-mediated activation of the Ras- and Rho-families of small G proteins, CVC - Herma Heart Center Research Day, Milwaukee, WI, 3/2/2005 - Present
16. Mechanisms controlling activation of Ras, Cdc42 and Rap1 small G-proteins by Endothelin-1. Invited presentation, Cell Signaling Research Club, Milwaukee, WI, 4/21/2005 - Present
17. Eicosanoids and resistance of cancer cells to apoptosis, Nephrology Research Conference, Milwaukee, WI, 7/2006 - Present
18. Endothelin signaling and Cox-2-mediated resistance cells to apoptosis, Human and Molecular Genetics Center, Milwaukee, WI, 8/2006 - Present
19. BK virus entry pathways and prevention of polyomavirus nephropathy after renal transplantation, Nephrology Research Conference, Milwaukee, WI, 12/2007 - Present
20. Endothelin-1signaling via GEFs C3G and BCAR3 in kidney glomerular cells, Cell Signaling Research Club, Milwaukee, WI, 2/2008 - Present
21. BK virus-induced signalling and entry pathways in renal tubular epithelial cells, Cell Signaling Research Club, Milwaukee, WI, 11/2008 - Present
22. Pix signaling: new pathways with new promise, Cardiovascular Research Center, Milwaukee, WI, 12/2008 - Present
23. BK virus entry pathways, Dept. of Microbiology and Molecular Genetics, Milwaukee, WI, 11/2009 - Present
24. Eicosanoids and growth of cancer cells, Inflammation and Cancer Cell Biology Research Group, Milwaukee, WI, 12/2009 - Present
25. Endothelin signaling and hypertension induced nephropathy, Hypertension Affinity Group. Cardiovascular Center, Milwaukee, WI, 3/2010 - Present
26. Cellular regulation of prostaglandin synthesis, Nephrology Research Conference, Milwaukee, WI, 3/2010 - Present
27. Eicosanoids and resistance of prostate cancer cells to chemotherapeutic agents, Fraternal Order of Eagles Wisconsin Chapter Annual Meeting, Wisconsin, 6/2010 - Present
28. p66 Shc and Cox-2 – relevant targets for Zinc Finger Nucleases-mediated genome editing to study renal pathologies, Stem Cells Affinity Group, Cardiovascular Center, Milwaukee, WI, 6/2010 - Present
29. BK virus entry pathways in proximal tubular epithelial cells, Milwaukee, WI, 7/2010 - Present
30. Cellular Regulation of Prostaglandin Synthesis, Inflammation and Cancer Cell Biology Research Group, Milwaukee, WI, 10/2010 - Present
31. Endothelin signaling and actions in renal mesangium, Nephrology Research Conference, Milwaukee, WI, 3/2011 - Present
32. Role of p66 Shc in hypertension induced renal vascular dysfunction, Hypertension Affinity Group, Milwaukee, WI, 6/2011 - Present
33. p66 Shc signaling in kidney cells, Cell Signaling Research Club
 
Regional
1. Stabilization of an active dimeric form of EGF receptor, Western Reserve University, Cleveland, OH, 7/1994 - Present
2. Invited Speaker Series, Northern Illinois University , DeKalb, IL, 1996 - Present
3. Mechanisms controlling activation of small G proteins by Endothelin-1, University of Michigan, Ann Arbor, MI, 4/27/2005 - Present
4. Endothelin signaling and hypertension-induced nephropathy, University of Toledo, Toledo, OH, 11/2009 - Present
5. Endothelin signaling and hypertension-induced nephropathy, Michigan State University, Lansing, MI, 4/2010 - Present
 
National
1. EGF receptor signaling, Memorial Sloan Kettering Cancer Center, New York, NY , 5/1994 - Present
2. Activation of the EGF and FGF receptor, Medical College of Georgia, Augusta, GA, 6/1994 - Present
3. Stabilization of an active dimeric form of the EGF receptor by introduction of an inter-receptor disulfide bond, Yale University, New Haven, CT, 6/1994 - Present
4. Stabilization of an active dimeric form of EGF receptor, Georgetown University, Washington, DC , 6/1994 - Present
5. Eicosanoid & Atherogenesis Symposium, 4th Winter Eicosanoid Conference 2002, Baltimore, MD, 3/2002 - Present
6. Regulation of Endothelin signaling by protein-protein interactions, University of North Carolina, Chapel Hill, NC, 2002 - Present
7. Eicosanoid & Atherogenesis Symposium, 5th Winter Eicosanoid Conference 2002, Baltimore, MD, 3/2003 - Present
8. Invited Talk, 7th Winter Eicosanoid Conference 2002, Baltimore, MD, 3/2005 - Present
9. Endothelin-9, International Conference , Salt Lake City, UT, 9/2005 - Present
10. Endothelin signaling and hypertension-induced nephropathy, North Dakota State University, Fargo, ND, 2/2010 - Present
11. Hypertension Induced Nephropathy, Texas Tech University Health Science Center, Amarillo, TX, 3/2010 - Present
12. Endothelin signaling and hypertension-induced nephropathy, University of Alaska, Faribanks, AK, 4/2010 - Present
13. Endothelin signaling and hypertension-induced nephropathy, University of Alaska , Anchorage, AK, 4/2010 - Present
14. Endothelin signaling and hypertension-induced nephropathy, University of Oklahoma, Oklahoma City, Oklahoma, 5/2010 - Present
15. Endothelin signaling and Mechanisms of Renal Injury, City College of New York, The Sophie Davis School of Biomedical Education, New York, 7/2010 - Present
 
International
1. Oligomerization and signaling by EGF and FGF receptor, Leopold Franzens University of Innsbruck, Insbruck, Austria , 1996 - Present
2. Cyclooxygenase 2, regulation of NO production and apoptosis in cancer, University of Florence, Florence, Italy , 2001 - Present
3. Endothelin signaling and regulation of protein kinases, University of Florence, Florence, Italy , 2001 - Present
4. Regulation of endothelin signaling by adaptor proteins, of Cytology of the Russian Academy of Sciences, St. Petersburg, Russia , 2002 - Present
5. Overexpression of Cox-2 Inhibits apoptosis In PC12 cells and glomerular mesangial cells, Leopold Franzens University of Innsbruck, Innsbruck, Austria , 2003 - Present
6. Apoptosis/Molecular Oncology , 11th World Congress on Advances in Oncology and 9th International Symposium on Molecular Medicine , Crete, Greece, 10/12/2006 - 10/14/2006
7. Mechanisms of endothelin receptor function and signaling, Tenth International Conference on Endothelin , Bergamo, Italy, 9/16/2007 - 9/19/2007
8. Pix: multi-purpose guanine nucleotide exchange factor, Second Meeting of the Russian Society for Cell Biology, St Petersburg, Russia, 10/16/2007 - 10/19/2007
9. Cellular regulation of the endothelin pathway, Eleventh APS International Conference on Endothelin , Montreal, Canada, 9/9/2009 - 9/12/2009
10. Endothelin signaling and new approaches to genome editing, Institute of Cytology of the Russian Academy of Sciences, St Petersburg, Russia, 3/2010 - Present
 
PEER REVIEWED WORKSHOPS/PRESENTATIONS:
Regional
1. Topic: C3G, ASN Annual Meeting , St. Louis, MO, 10/2004 - Present
 
National
1. Molecular mechanisms controlling activation of Rap1 by Endothelin-1 in human mesangial cells, Ninth International Conference on Endothelin. Endothelin-9, Park City, UT, 9/11/2005 - 9/14/2005
2. Endothelin-1 induces 1Pix translocation and Cdc42 activation via protein kinase A pathway, Ninth International Conference on Endothelin. Endothelin-9, Park City, UT, 9/11/2005 - 9/14/2005
3. Topic: BK virus, ASN National Meeting 2007, San Francisco, CA, 10/2007 - Present
4. Topic: Pix and ENaC, ASN Annual Meeting 2009, San Diego, CA, 10/27/2009 - 11/1/2009
 
International
1. Oral Presentation, Seventh International Conference on Endothelin, Edinburgh, Scotland , 10/2001 - Present
2. Eicosanoids and resistance of cancer cells to apoptosis, 11th World Congress on Advances in Oncology and the Internal Symposium on Molecular Medicine, Crete, Greece, 10/12/2006 - 10/14/2006
3. Topic – C3G. Tenth International Conference on Endothelin, Endothelin-10, Bergamo, Italy, 2007
4. Topic: BK virus, American Transplantation Congress, Toronto, Canada , 6/2008 - Present
5. Topic – BK virus, Eleventh International Congress on Endothelin, Endothelin-11, Montreal, Canada , 9/9/2009 - 9/12/2009
6. Topic: ENaC, Eleventh International Congress on Endothelin, Endothelin-11, Montreal, Canada , 9/9/2009 - 9/12/2009
 
COMMITTEE SERVICE:
Medical College
1/1999 - 12/2001 Member, ARC Faculty Advisory Committee, Medical College of Wisconsin
7/2001 - 7/2008 Co-Director, Weekly Nephrology Research Conference, Medical College of Wisconsin
1/2002 - 12/2006 Director, CVC Seminar Series Cardiovascular Research Center, Medical College of Wisconsin
7/2002 - Present Member, Research Honors Committee, Medical College of Wisconsin
2002 Reviewer, Annual Research Day Poster Session, Medical College of Wisconsin
7/2005 - 7/2006 Member, Interdepartmental Search Committee , Recruitment in Cancer Research, Medical College of Wisconsin
2005 - 2007 Member, Committee for Reviewing Graduate Student Poster Day, Medical College of Wisconsin
2005 - 2007 Interviewer, Admission Interviews for Graduate School of Biomedical Sciences, Medical College of Wisconsin
2007 - 2009 Member, Mentoring Committee , Junior Faculty Dr. Niloofa Tabatabai, Medical College of Wisconsin
2008 - Present Member, Awards Committee , Graduate Studies Council, Medical College of Wisconsin
2009 Member, Cancer Center’s Research Grants Committee for the fall 2009 cycle, Medical College of Wisconsin
2009 - 2010 Member, MCW Clinical and Translational Science Institute Grant Review Committee, Medical College of Wisconsin
2009 - 2010 Scientific Reviewer , medical student “summer research” poster presentation, Medical College of Wisconsin
2009 Member, Local Review Committee , American Cancer Society Institutional Research Grant (ACS-IRG), Medical College of Wisconsin
2009 - 2010 Member, Committee for Reviewing Graduate Student Poster Day, Medical College of Wisconsin
11/2010 - Present Co-Director, KDC Seminar Series, Medical College of Wisconsin
2010 - Present Member, CTSI Clinical Scientist Mentoring Team, Medical College of Wisconsin
2011 Member, Cancer Center Research Grants Committee, Medical College of Wisconsin
 
MEDICAL COLLEGE TEACHING ACTIVITIES:
Medical Student Education
1997 - Present Advanced Molecular Genetics Course, Dept. Biochemistry; 3 hours teaching and exam questions
1999 - Present Membrane Biochemistry and Signal Transduction, Dept. Biochemistry; 3 hours teaching and exam questions
1999 - Present Principles of Drug Action II: Intracellular Signaling, 1999 Dept. Pharmacology; 3 hours teaching and exam questions
2001 - Present Principles of Drug Action: Cellular Signal Transduction, Dept. Pharmacology; 3 hours teaching and exam questions
2001 - 2003 Basic Science Curriculum, Dept. Medicine, (one lecture/year)
2002 - Present Principles of Drug Action: Cellular Signal Transduction, Dept. Pharmacology; 3 hours teaching and exam questions
2004 - Present Principles of Drug Action: Cellular Signal Transduction, Dept. Pharmacology, 3 hours teaching and exam questions
2005 - Present Biochemistry of the Cell (Course # 16201), Interdisciplinary Graduate Program in Biomedical Science; 4 hours teaching and exam questions
2006 - Present Cell Signaling Course, Dept. Pharmacology, 4 hours teaching and exam questions
2008 - Present Cellular Signal Transduction course, Dept. Pharmacology; 4 hours teaching and exam questions.
2008 - Present Mechanisms of Cellular Signaling, Dept. Pharmacology, 4 hours teaching and exam questions.
2009 - Present Molecular Biology for Physiologists, Dept. Physiology; 4 hours teaching and exam questions
2010 - Present Cellular Signal Transduction course, Dept. Pharmacology; 3 hours teaching and exam questions.
2010 - Present Molecular Biology for Physiologists, Dept. Physiology; 4 hours teaching and exam questions.
 
EXTRAMURAL TEACHING (e.g. at Marquette, UWM, etc.):
Medical Student Education
2010 - Present University of Alaska, WWAMI Microbiology course (invited lecture), Anchorage; 2 hours teaching
 
MCW STUDENTS, FACULTY, RESIDENTS AND CLINICAL/RESEARCH FELLOWS MENTORED:
Graduate Students
MS
Olivera Grubisha, Medical College of Wisconsin, 1998 - Present
Committees
Christina Spofford, MD/PhD , Medical College of Wisconsin, 1999 - 2001
Jeremy Nichols, PhD, Medical College of Wisconsin, 2005 - 2006
Nikole Pohl, PhD , Medical College of Wisconsin, 2006 - 2008
Julie K. Antczak , Medical College of Wisconsin, 2006 - 2007
Gaik Wei Tew, Medical College of Wisconsin, 2006 - Present
MS Committees
Vik Kumar, Medical College of Wisconsin, 2000 - Present
Eric Gross, Medical College of Wisconsin, 2002 - Present
Adam Harder, Medical College of Wisconsin, 2003 - Present
James Henkel, Medical College of Wisconsin, 2004 - Present
Thomas L. Rummel, Medical College of Wisconsin, 2004 - Present
James Wahlberg, Medical College of Wisconsin, 2005 - Present
Tania Bakshi, Medical College of Wisconsin, 2005 - Present
Dharini van der Hoeven, Medical College of Wisconsin, 2005 - Present
Chen Chen, Medical College of Wisconsin, 2005 - Present
Malathi Narayan, Medical College of Wisconsin, 2005 - Present
Hong Guan, Medical College of Wisconsin, 2006 - Present
Andrew Podd, Medical College of Wisconsin, 2006 - Present
Soonyean Hwang, Medical College of Wisconsin, 2007 - Present
Fengjie Liu, Medical College of Wisconsin, 2007 - Present
Adam Gastonguay, Medical College of Wisconsin, 2007 - Present
Anna Alexanian, Medical College of Wisconsin, 2009 - Present
PhD Students Advised
Thomas L. Rummel , Medical College of Wisconsin, 6/2004 - 3/2005
Anna Alexanian, Medical College of Wisconsin, 6/2009 - Present
Chen Chen, Medical College of Wisconsin, 2005 - Present
Malathi Narayan, Medical College of Wisconsin, 2005 - Present
Adam Gastonguay, Medical College of Wisconsin, 2007 - Present
Anna Alexanian, Medical College of Wisconsin, 2009 - Present
 
Clinical/Research Fellows
Nickolai Dulin, Ph.D., Medical College of Wisconsin, 1996 - 1999
Marco Foschi, M.D., Medical College of Wisconsin, 1996 - 1998
Ann McGinty, Ph.D., Medical College of Wisconsin, 1996 - 1998
Edith Chang, Ph.D., Medical College of Wisconsin, 1998 - 2000
Simon Prosser, Ph.D., Medical College of Wisconsin, 1998 - 2003
Vimal Patel, Ph.D,, Medical College of Wisconsin, 2000 - 2003
Adiba Ishaque, Ph.D., Medical College of Wisconsin, 2000 - 2003
(3 students), Medical College of Wisconsin, 2001 - 2004 Preceptor of Minority Summer Research Training Program
Ludmila C. Aslanukov, Medical College of Wisconsin, 2001 - Present
Ahmed Chahdi, Ph.D., Medical College of Wisconsin, 2001 - 2009
Andries Liepins, Ph.D., Medical College of Wisconsin, 2001 - 2002
Alexey Parfenyev, Ph.D., Medical College of Wisconsin, 2003 - 2006
Victoriya Petrukhina, Ph.D., Medical College of Wisconsin, 2003 - 2008
Chunzhi Xia, M.D., Ph.D. , Medical College of Wisconsin, 2005 - 2007
Takahito Moriyama, M.D., Ph.D. , Medical College of Wisconsin, 2006 - 2007
Chen Yang, Ph,D., M.D., Medical College of Wisconsin, 2006 - 2010
 
EXTRAMURAL STUDENTS, FACULTY, RESIDENTS, AND CLINICAL/RESEARCH FELLOWS MENTORED:
Graduate Students
Committees
Rajendra K. Kothinti, PhD , UW Milwaukee, 2008 - Present
 
Clinical/Research Fellows
Dirk Bokemeyer, M.D., Medical College of Wisconsin, 1995 - 1997
Phillip Pratt, Ph.D., Medical College of Wisconsin, 1999 - 2001
 

BIBLIOGRAPHY
Refereed Journal Publications/Original Papers
1. SOROKIN, A.B. Proliferation and DNA synthesis in a CHO-K1 cell culture with a varying serum concentration in the medium. Tsitologiya 23:468-472, 1981.
2. Vinogradova N., SOROKIN, A.B, Nikolsky N.N. Transport of D-xylose in cultured animal cells. Studia Biophysica, 85:23-24, 1981.
3. SOROKIN, A.B., Sorkin A.D., Nikol'skii N.N. Uridine transport and phosphorylation in 3T3 and CHO cells with induced cell proliferation. Tsitologiya, 23:523-530, 1981.
4. SOROKIN, A.B., Sorkin A.D., Nikol'skii N.N. Uridine transport and phosphorylation in 3T3 and CHO cells depending on the culture growth conditions. Tsitologiya, 23: 419-426, 1981.
5. Zenin V.V., Nikol'skii N.N., Scopicheva V.I., SOROKIN, A.B. Dependence of 3T6 cell proliferation on the serum concentration in the medium. Tsitologiya, 24: 947-953, 1982.
6. Sorkin A.D., SOROKIN, A.B. Mathematical analysis and experimental study of uridine transport and phosphorylation in 3T6 cells. Tsitologiya, 25: 784-792, 1983.
7. Barkan R.S., Zenin V.V., Scopicheva V.I., SOROKIN, A.B. Effect of cultivation conditions on the growth properties of Swiss 3T3 cells. Tsitologiya, 26:1161-1167, 1984.
8. Nikol'skii N.N., Barkan R.S., Bogdanova N.P., Vinogradova N.A., SOROKIN, A.B. Amine inhibition of serum-induced DNA synthesis in 3T3 and 3T6 cell cultures. Tsitologiya, 27: 451-457, 1985.
9. Sorkin A.D., Bogdanova N.P., Nikol'skii N.N., SOROKIN, A.B. Effect of amines on the pH in the lysosomes of 3T3 cells. Tsitologiya, 27: 203-208, 1985.
10. Scopicheva V.I., Scopichev V.G., SOROKIN, A.B., Nikol'skii N.N. Changes in the surface topography of 3T3 cells as affected by epidermal growth factor and insulin. Tsitologiya, 28:1316-1321, 1986.
11. Scopicheva V.I., Scopichev V.G., SOROKIN, A.B Characteristics of the surface topography of Swiss 3T3 cells with altered proliferative activity. Tsitologiya, 28: 687-692, 1986.
12. Gudkova D.A., SOROKIN, A.B. Dependence of the proliferation of cell line 3T6 on a totally serum-free medium on epidermal growth factor. Tsitologiya, 29: 1309-1313, 1987.
13. Nesterov A.M., Vinogradova N.A., Kudriavtseva N.V., Sorkin A.D., SOROKIN, A.B. Effect of dansylcadaverine on the epidermal growth factor-stimulated phosphorylation of uridine. Tsitologiya, 29: 1020-1026, 1987.
14. Nesterov A.M., SOROKIN, A.B., Okulova A.N., Nikol'skii N.N. Comparison of the effect of the epidermal growth factor (EGF) and its cyanogen bromide derivative on EGF receptor phosphorylation and uridine uptake in a cell culture. Tsitologiya, 29: 911-916, 1987.
15. Gracheva N.I., Pereverzev A.E., SOROKIN, A.B. Effect of the epidermal growth factor on the repopulation of bone marrow CFU-Cs following radiation thermal injury. Meditsinskaia Radiologiia, 32: 76-77, 1987.
16. SOROKIN, A.B., Romanov V.I., Komissarchik I.Y., Nikol'skii N.N. Immunocytochemical localization of epidermal growth factor receptors on plasma membrane of A-431 cells. Doklady Akademii Nauk Sssr, 300: 974-976, 1988.
17. Romanov V.I., SOROKIN, A.B., Nesterov A.M., Komissarchik I.Y. Ultrastructural changes in the plasma membrane of A-431 cells exposed to epidermal growth factor. Tsitologiya, 30: 34-38, 1988.
18. Kornilova E.S., Bobrova I.F., Nesterov A.M., Nikol'skii N.N., SOROKIN, A.B. Demonstration of an intact complex of epidermal growth factor and its receptor in the endosomes of A-431 cells. Tsitologiya, 30:291-298, 1988.
19. Gracheva N.I., Zhestianikov V.D., Bil'din V.N., Pereverzev A.E., SOROKIN, A.B. Epidermal growth factor with insulin used for stimulation of exogenous colony formation in the spleen of mice irradiation with lethal doses of x-rays. Tsitologiya, 30: 58-61, 1988.
20. Sorkin A., Kornilova E., Teslenko L., SOROKIN, A., Nikolsky N. Recycling of epidermal growth factor-receptor complexes in A431 cells. Biochemica et Biophysica Acta, 1011: 88-96, 1989.
21. Khrebtukova I.A., Nikol'skaia A.N., Sorkin A.D., SOROKIN, A.B Pinaev G.P. The capping of receptors for the epidermal growth factor and the participation of the cytoskeleton in this process in A-431 cells. Tsitologiya, 31: 1211-1220, 1989.
22. Gudkova D.A., SOROKIN, A.B. Cell strains of A431 epidermoid carcinoma with altered epidermal growth factor reception. Tsitologiia, 31: 319-323, 1989.
23. Sorkin A.D., Bogdanova N.P., SOROKIN, A.B., Teslenko L.V., Nikol'skii N.N. The recycling of EGF-receptor complexes in A431 cells. Tsitologiya, 31: 300-311, 1989.
24. SOROKIN, A.B., Nesterov A.M., Sorkin A.D., Ignatova T.N., Galactionov K.I. Isolation and characterization of monoclonal antibodies to the external domain of the EGF receptor in human A431 epidermoid carcinoma. Tsitologiya, 31: 549-555, 1989.
25. SOROKIN, A.B., Romanov V., Reshetnikova, G.F., Nesterov A.M., and Nikolsky N.N. Immunocytochemical location of EGF receptors in A 431 cells. Cell Differentiation and Development 27: Suppl.34: 3-8.
26. Ronnstrand L., SOROKIN, A.B., Engstrom U., Heldin C.H. Characterization of the platelet-derived growth factor beta-receptor kinase activity by use of synthetic peptides. Biochemical Biophysical Research Communications, 167: 1333-1340, 1990.
27. SOROKIN, A.B., Reshetnikova G.F., Kudryavtseva N.V., Nikolsky N.N. Epidermal growth factor induces tyrosine phosphorylation of epidermal growth factor receptors not occupied with ligand in intact A431 cells. Febs Letters, 268: 121-124, 1990.
28. SOROKIN, A.B., Gudkova D.A., Kudriavtseva N.V., Nikol'skii N.N. The ligand-dependent phosphorylation of epidermal growth factor receptors and the production of a secreted form of the receptor by cell strains of A-431 epidermoid carcinoma. Tsitologiya, 32: 1026-1030, 1990.
29. Khrebtukova I.A., Kwiatkowska K., Gudkova D.A., SOROKIN, A.B., Pinaev G.P. The role of microfilaments in the capping of epidermal growth factor receptor in A431 cells. Experimental Cell Research, 194: 48-55, 1991.
30. SOROKIN, A.B., Alexandrov K.E., Vinogradova N.A., A.M. Nesterov, N.N.Nikolsky. The obtaining and characteristics of polyclonal antibodies to a treonine-containing site of the EGF receptor cytoplasmic domain. Tsitologiya, 35: 68-72, 1993.
31. Mohammadi M., Honegger, A., SOROKIN, A., Ullrich, A., Shlessinger J., Hurwitz D.R. Aggregation-induced activation of the Epidermal Growth Factor receptor protein tyrosine kinase. Biochemistry, 1993, 32, 8742-8748.
32. SOROKIN, A., Lemmon, M.A., Ullrich, A., and Schlessinger J. Stabilization of an active dimeric form of the EGF receptor by introduction of an inter-receptor disulfide bond. J.Biol.Chem. 1994, 269, 9752-9759.
33. SOROKIN, A., Mohammadi, M., Huang, J., and Schlessinger, J. Internalization of Fibroblast Growth Factor Receptor is inhibited by a point mutation at tyrosine 766. J.Biol.Chem. 1994, 269, 17056-17061.
34. Schramek, H., SOROKIN, A., Watson, R.D., and Dunn, M.J. ET-1 and PDGF BB induce MEK mRNA and protein expression in mesangial cells. J. Cardiovasc. Pharmacol. 1995, 26(Suppl.3):S95-S99.
35. SOROKIN, A. Activation of EGF receptor by insertional mutations in juxtamembrane regions. Oncogene 1995, 11:1531-1540.
36. Bokemeyer D., SOROKIN, A., Yan M., Ahn, N.G., Templeton, D., and Dunn M.J. Induction of the Dual Specificity Phosphatase MKP-1 by SAPK Signaling pathway but not by ERK. J.Biol.Chem. 1996, 271:639-642.
37. Schramek H., SOROKIN, A., Watson R.D., and Dunn, M. Differential Long-term regulation of mitogen-activated protein kinase kinase (MAPKK or MEK) and of p42 MAPK in rat glomerular mesangial cells. American J. Physiol., 1996, 270:C40-C48.
38. Mohammadi M., Dikic, I., SOROKIN, A., Burgess, W.H., Jaye, M., and Schlessinger, J. Identification of six novel autophosphorylation sites on Fibroblast Growth Factor Receptor-1 and elucidation of their importance in receptor activation and signal transduction. Mol.Cell.Biol. 1996, 16: 977-989.
39. Bokemeyer D., SOROKIN, A., and Dunn, M.J. The dual specificity protein-tyrosine phosphatases CL100, B23 and PAC1: Differential regulation and expression. J.Amer. Soc. Nephrol. 1997, 8: 40-50.
40. Bokemeyer, D., Guglielmi, K.E., McGinty, A., SOROKIN, A., Lianos, E.A., and Dunn, M.J. Activation of extracellular signal-regulated kinase in proliferative glomerulonephritis in rats. Journal. Clinical. Investigat. 100: 582-588. 1997
41. Foschi M., Chari, S., Dunn, M.J., and SOROKIN, A., Biphasic activation of p21ras by endothelin-1 sequentially activates the ERK cascade and phosphatidylinositol 3-kinase. EMBO J. 16:6439-6451, 1997.
42. SOROKIN, A., Reed, E., Nkemere N., Dulin N.O., and Schlessinger J., Crk Protein Binds to PDGF Receptor and Insulin Receptor Substrate-1 with Different Modulating Effects on PDGF- and Insulin-dependent Signaling Pathways. Oncogene, 16:2425-2434, 1998.
43. SOROKIN, A., and Reed A. Insulin stimulates the tyrosine dephosphorylation of docking protein p130cas (Crk-associated substrate), promoting the switch of the adaptor protein Crk from p130cas to newly phosphorylated insulin receptor substrate-1. Biochemical J. 334:595-600, 1998.
44. Bokemeyer, D. Guglielmi, K.E., McGinty, A., SOROKIN, A., Lianos E.A., and Dunn M.J. Different activation of mitogen-activated protein kinases in experimental proliferative glomerulonephritis. Kidney International, 54: S-189-S-191, 1998
45. Bokemeyer, D., SOROKIN, A., Dunn, M.J., Meyer-Lehnert H., and Kramer, H.J. Intrazellulare Signaltransduktion durch mitogen-aktivierte Proteinkinasen. Nieren- und Hochdruckkrankheiten, 27:67-74, 1998
46. Dulin, N.O., SOROKIN, A., Douglas, J.C. Arachidonate-induced tyrosine phosphorylation of epidermal growth factor receptor and Shc-Grb2-Sos association. Hypertension, 32:1089-1093, 1998.
47. Dulin, N.O., SOROKIN, A., Reed, E., Elliott, S., Kehrl, J.H., and Dunn, M.J. RGS3 inhibits G protein - mediated signaling via translocation to the membrane and binding to G11. Mol. Cell. Biol. 19:714-723, 1999.
48. McGinty A., Chang Y.-W. SOROKIN, A., Bokemeyer D., and Dunn M.J. Cyclooxygenase II expression inhibits trophic withdrawal apoptosis in nerve growth factor differentiated PC12 cells. J. Biol. Chem. 275:12095-12101, 2000
49. Chang, Y.W., Jakobi, R. McGinty, A., Foschi, M., Dunn, M.J. and SOROKIN, A. Cycooxygenase-2 promotes cell survival by stimulation of Dynein Light Chain Expression and inhibition of neuronal nitric oxide synthase activity. Molec. Cell. Biol. 20:8571-8579, 2000
50. McGinty, A., Foschi, M., Chang, Y.W., Han, J., Dunn, M.J. and SOROKIN, A. Induction of Prostaglandin Synthase-2 by Mitogen-Activated Protein Kinase Cascades. Biochem. J., 352:419-424, 2000
51. SOROKIN, A., Kozlowski, P., Graves, L., and Philip, A. Protein tyrosine kinase Pyk2 mediates endothelin-induced p38 MAP kinase activation in glomerular mesangial cells. J. Biol. Chem. 276:21521-21528, 2001
52. Foschi, M., Franchi, F., Han, J., La Villa, G., and SOROKIN, A. Endothelin-1 Induces Serine Phosphorylation of the adaptor protein p66Shc and its Association with 14-3-3 Protein in Glomerular Mesangial Cells. J. Biol. Chem. 276:26640-26647, 2001
53. Foschi, M., SOROKIN, A., Pratt, P. McGinty, A., La Villa, G., Franchi, F., and Dunn M.D. PreproEndothelin-1 expression in human mesangial cells: evidence for a p38 mitogen activated protein kinase/Protein kinases-C dependent mechanism. J. Amer. Soc. Nephrol., 12:1151-1163, 2001
54. Patel, V., M. Dunn and SOROKIN, A. Regulation of MDR-1 (P-glycoprotein) by cyclooxygenase-2. J. Biol. Chem., 277:38915-38920, 2002
55. SOROKIN, A., Foschi, M. and Dunn, M.J. Endothelin signalling and regulation of protein kinases in glomerular mesangial cells. Clinical Science 103 (Suppl. 48), 132S-136S, 2002
56. Miller, B., Chang Y.-W.E. and SOROKIN, A. Cyclooxygenase 2 Inhibits SAPK activation in neuronal apoptosis. Biochem. Biophys. Res. Comm. 300:884-888, 2003
57. Ishaque, A., Dunn M.J. and SOROKIN, A. Cyclooxygenase-2 inhibits TNF-mediated apoptosis in renal glomerular mesangial cells. J. Biol. Chem., 278: 10629-10640, 2003.
58. Prosser, S., Sorokina, E., Pratt, P., H. and SOROKIN, A. CrkIII: A novel and biologically distinct member of the Crk family of adaptor proteins. Oncogene, 22:4799-4806, 2003.
59. Pratt, P.P., Bokemeyer, D., Foschi, M., SOROKIN, A., and Dunn, M.J. Alterations In subcellular localization of p38 MAPK potentiate endothelin-stimulated COX-2 expression in glomerular mesangial cells. J. Biol. Chem., 278: 51928-51936, 2003.
60. Chahdi, A., SOROKIN, A., Dunn, M.J. and Landry Y. The Rac/Cdc42 guanine nucleotide exchange factor b1Pix enhances mastoparan-activated Gi-dependent pathway in mast cells. Biochem Biophys Res Commun. 317:384-389. 2004
61. Jiang, J., Borisenko, G.G., Osipov, A., Martin, I., Chen, R., Shvedova, A.A., SOROKIN, A., Tyurina, Y.Y., Potapovich, A., Tyurin, V.A., Graham, S.H., and Kagan, V.E. Arachidonic Acid-Induced Carbon-centered Radicals and Phospholipid Peroxidation in Cyclooxygenase-2 transfected PC12 cells. J Neurochem. 90:1036-1049; 2004.
62. Chahdi, A., Miller, B. and SOROKIN, A. Endothelin 1 induces 1Pix translocation and Cdc42 activation via protein kinase A-dependent pathway. J Biol Chem. 280: 578-584; 2005
63. Zhao, Q., Shepherd, E., Manson, M., Nelin, L., SOROKIN, A., and Liu Y. The role of mitogen-activated protein kinase phosphatase-1 in the response of alveolar macrophages to lipopolysaccharide: Attenuation of proinflammatory cytokine biosynthesis via feedback control of p38. J Biol Chem. 280:8101-8108, 2005
64. Chahdi, A., and SOROKIN, A. Endothelin-1 stimulates 1Pix-dependent activation of Cdc42 through Gs-pathway. Exp. Biol. Med. 231:761-765, 2006
65. Rufanova V. and SOROKIN, A. CrkII Associates with BCAR3 in Response to Endothelin-1 in Human Glomerular Mesangial Cells. Exp. Biol. Med. 231:752-761, 2006
66. Miller, B., Patel, V. and SOROKIN, A. COX-2 rescues rat mesangial cells from apoptosis induced by adriamycin via upregulation of MDR1 (P-glycoprotein). J Am Soc Nephrol. 17:977-985, 2006
67. Huh, J., Liepins, A., Zielonka J., Andrekopoulos, C., Kalyanaraman, B., and SOROKIN, A. Cyclooxygenase 2 rescues LNCaP prostate cancer cells from sanguinarine induced apoptosis by mechanism involving inhibition of nitric oxide synthase activity. Cancer Research, 66:3726-3736, 2006
68. Sarközi, R., Miller, B., Pollack, V., Feifel, F., Mayer, G., SOROKIN, A. and Schramek, H. ERK1/2-driven and MKP-mediated inhibition of EGF-induced ERK5 signaling in human proximal tubular cells. J. Cellul. Physiol. 211: 88-100, 2007
69. Yang, C., Patel, K., Harding, P., SOROKIN, A., Glass WF 2nd. Regulation of TGF-beta1/MAPK-mediated PAI-1 gene expression by the actin cytoskeleton in human mesangial cells. Exp.Cell Res. 313:1240-1250, 2007
70. Moriyama, T., Marquez, J.P., Wakatsuki, T and SOROKIN, A. Caveolar endocytosis is critical for BK virus infection of human renal proximal tubular epithelial cells. J.Virol. 81:8552-8562, 2007
71. Moriyama, T. and SOROKIN, A. Intracellular trafficking pathway of BK virus in human renal proximal tubular epithelial cells. Virology, 371:336-349, 2008
72. Chahdi, A., and SOROKIN, A. PKA-dependent phosphorylation modulates β1Pix-GEF activity through 14-3-3β binding. Molec. Cell. Biol.28:1697-1687, 2008
73. Moriyama, T. and SOROKIN, A. Repression of BK virus infection of human renal proximal tubular epithelial cells by pravastatin. Transplantation. 85:1311-1317, 2008
74. Chahdi, A. and SOROKIN, A. Endothelin-1 couples Pix to p66Shc: Role of Pix in Cell Proliferation through FOXO3a phosphorylation and p27kip1 Down-regulation Independently of Akt. Molec. Biol. Cell 19:2609-2619, 2008.
75. Rufanova V.A., Lianos, E, Alexanian, A., Sorokina, E., Sharma, M., McGinty, A and SOROKIN, A. C3G overexpression in glomerular epithelial cells in anti-GBM glomerulonephritis. Kidney International, 75:31-40, 2009.
76. Rufanova V.A., Alexanian, A., Wakatsuki, T., Lerner A., and SOROKIN, A. Pyk2 mediates Endothelin-1 signaling via p130Cas/BCAR3 Cascade and regulates human glomerular mesangial cell adhesion and spreading. J. Cell Physiol., 219:45-56 2009.
77. Rufanova V.A., Alexanian, A., Wakatsuki, T. and SOROKIN, A. Pyk2 controls filamentous actin formation in human glomerular mesangial cells via modulation of profilin expression. Cell Health and Cytoskeleton, Open Access Free Article, 2009. http://www.dovepress.com/3254.t241782
78. Alexanian A., Rufanova V.A., Miller, B., Flasch, A., Roman, R., and SOROKIN,A . Down-regulation of 20-HETE Synthesis and Signaling Inhibits Renal Adenocarcinoma Cell Proliferation and Tumor Growth. Anticancer Research 29:3819-3824, 2009.
79. Chahdi, A. and SOROKIN, A. Endothelin-1 induces p66 Shc activation through EGF receptor transactivation: Role of 1Pix/Gi3 interaction. Cellular Signal. 22:325-329, 2010 http://dx.doi.org/10.1016/j.cellsig.2009.09.039
80. Chahdi, A. and SOROKIN, A. The role of 1Pix/caveolin-1 interaction in endothelin signaling through G subunits. Biochem. Biophys. Res. Commun., doi:10.1016/j.bbrc.2009.12.041, 391:1330-1335, 2010.
81. Pavlov T.S., Chahdi A., Vachugova D.V., Levchenko V., Vandewalle A., Pochynyuk O., SOROKIN, A. * and Staruschenko A*. Endothelin-1 regulates the epithelial Na+ channel via βPix/14-3-3/Nedd4-2 complex. * co-corresponding author. JASN, 21:833-843, 2010.
82. Rufanova V. A., Alexanian A., Ostendorf T., Bokemeyer D., Prosser S., Miller B. and SOROKIN, A. Endothelin signaling via guanine exchange factor C3G in renal glomerular mesangial cells. Can. J. Physiol. Pharmacol., 88:808-816, 2010
83. Yang, C., and SOROKIN, A. Upregulation of fibronectin expression by COX-2 is mediated by interaction with ELMO1. Cellular Signal. 23: 99-104, 2011 http://www.ncbi.nlm.nih.gov/pubmed/20732417
84. SOROKIN, A. Complexity of IFN signaling gets another twist. Cell Cycle, 2011. In press.
 
Books, Chapters, and Reviews
1. SOROKIN, A.B., Nikol'skii N.N. Epidermal growth factor: membrane reactions and intracellular processing. In Biological membranes and membrane active agents FAN, Tashkent, 1985, (in Russian).
2. Nikolskii N.N., Sorkin A.D. SOROKIN, A.B. Epidermal Growth Factor. Nauka, 1987, 200 pages.
3. Bokemeyer D., SOROKIN, A., and Dunn, M.J. Multiple intracellular MAP kinase signaling cascades. Kidney International, 1996, 49:1187-1198.
4. SOROKIN, A. and Kohan, D. Physiology and pathology of endothelin-1 in the renal mesangium. AJP: Renal Physiology, Am. J. Physiol. Renal Physiol. 285: F579-F589, 2003.
5. SOROKIN, A. Cyclooxygenase-2: potential role in regulation of drug efflux and multiudrug
6. resistance phenotype. Curr. Pharm. Des. 10: 647-657, 2004.
7. Moriyama, T. and SOROKIN, A. BK Virus (BKV): Infection, Propagation, Quantitation, Labeling, and Analysis of Cell Entry in Current protocols in Cell Biology, 26.2.1-26.2.13, 2009
8. SOROKIN, A. Endothelin Signaling and Actions in the Renal Mesangium in Contributions to Nephrology, Barton M, Kohan DE (eds): Endothelin in Renal Physiology and Disease, Contrib. Nephrol. Basel, Karger, 173:50-62, 2011
9. SOROKIN, A. Glomerulonephritis and cellular regulation of prostaglandin synthesis in
10. Glomerulonephritis, Book 1 ISBN, 2011, In press.