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CURRICULUM VITAE

Brandon J. Tefft PhD
Assistant Professor
Department of Biomedical Engineering

OFFICE ADDRESS:
Translational and Biomedical Research Center
8701 Watertown Plank Rd
Milwaukee, WI 53226

EDUCATION:
08/2001 - 05/2005 BS, University of Illinois at Urbana-Champaign, Urbana, IL
09/2005 - 12/2008 MS, Northwestern University, Evanston, IL
09/2005 - 08/2011 PhD, Northwestern University, Evanston, IL

POSTGRADUATE TRAINING AND FELLOWSHIP APPOINTMENTS:
11/2011 - 03/2018 Postdoctoral Research Fellow, Cardiovascular Medicine, Mayo Clinic, 200 First St SW, Rochester, MN 55905

FACULTY APPOINTMENTS:
04/2018 - Present Assistant Professor, Biomedical Engineering, Medical College of Wisconsin & Marquette University, 8701 W. Watertown Plank Rd., Milwaukee, WI 53226

AWARDS AND HONORS:
05/2005 University Honors, University of Illinois at Urbana-Champaign
09/2005 - 05/2006 Royal E. Cabell Fellowship, Northwestern University
06/2006 - 05/2009 Graduate Research Fellowship Program Award, National Science Foundation
03/2014 - 03/2016 T32 Award, NIH/NHLBI

MEMBERSHIPS IN HONORARY AND PROFESSIONAL SOCIETIES:
05/2008 - 05/2009 American Association for the Advancement of Science (Member)
05/2010 - Present Tissue Engineering and Regenerative Medicine International Society (Member)
08/2010 - Present Biomedical Engineering Society (Member)
05/2015 - Present American Heart Association (Member)

EDITORSHIPS/EDITORIAL BOARDS/JOURNAL REVIEWS:
Journal Review
Cellular and Molecular Bioengineering
Materials and Design
Recent Patents on Cardiovascular Drug Development
Recent Patents on Regenerative Medicine
Tissue Engineering
Acta Biomaterialia
Nanomedicine: Nanotechnology, Biology, and Medicine
Ad-Hoc Reviewer
07/2017 Abstract reviewer, Biomedical Engineering Society annual meeting

RESEARCH GRANTS/AWARDS/CONTRACTS/PROJECTS:
Active
Peer Review
Title:
Nanotechnology for magnetic endothelialization of implantable cardiovascular devices
Source:
NIH/NHLBI
Role:
Principal Investigator
Dates:
08/01/2018 - 07/31/2021
Direct Funds:
$487,870 (total for all years)
 
Pending
Peer Review
Title:
Development of cardiovascular regenerative engineering strategies using nanotechnology platforms
Source:
MCW Advancing a Healthier Wisconsin endowment
Role:
Co-Investigator
PI:
Andrew S. Greene
Dates:
07/01/2018 - 06/30/2021
Direct Funds:
$519,098 (total for all years)
 
Title:
Novel stent-graft platform to treat vascular malformations using innovative magnetic nanotechnology and vascular occluders
Source:
Department of Defense CDMRP/PRMRP
Role:
Co-Investigator
PI:
Dan Dragomir-Daescu
Dates:
06/01/2019 - 05/31/2022
Direct Funds:
$1,508,871 (total for all years)
 
Prior
Peer Review
Title:
Nanotechnology for magnetic endothelialization of implantable cardiovascular devices
Source:
NIH/NHLBI
Role:
Principal Investigator
Dates:
04/18/2016 - 03/31/2018
Direct Funds:
$247,100 (total for all years)
 
Title:
Nanotechnology for magnetic endothelialization of implantable cardiovascular devices
Source:
Mayo Clinic CCaTS
Role:
Principal Investigator
Dates:
05/01/2016 - 07/31/2018
Direct Funds:
$158,461 (total for all years)
 

INVITED LECTURES/WORKSHOPS/PRESENTATIONS:
Local
Tefft BJ, Next-generation implantable cardiovascular devices developed with a regenerative medicine approach, Center for Clinical and Translational Science Grand Rounds, Mayo Clinic, Rochester, MN, 02/2016
Tefft BJ, Implantable cardiovascular devices developed with a tissue engineering approach, Physiology & Biomedical Engineering Seminar, Mayo Clinic, Rochester, MN, 09/2016
 
National
Tefft BJ, Design of a tissue engineered heart valve capable of remodeling, growth, and repair, Design of Medical Devices 2014, Minneapolis, MN, 04/2014
Tefft BJ, Rapid endothelialization of coronary stents by magnetic cell targeting, Design of Medical Devices 2015, Minneapolis, MN, 04/2015
 

PEER REVIEWED WORKSHOPS/PRESENTATIONS:
National
Tefft BJ, Kopacz AM, Liu WK, Liu SQ, Knockdown of SHP-1 enhances endothelial cell retention for vascular regeneration, ASME2010 First Global Congress on NanoEngineering for Medicine and Biology, Houston, TX, 02/2010
Tefft BJ, Uthamaraj S, Harburn JJ, Klabusay M, Hlinomaz O, Holmes DJ, Simari RD, Dragomir-Daescu D, Sandhu GS, Magnetic capture of endothelial cells to vascular stents, Biomedical Engineering Society 2013, Seattle, WA, 09/2013
Tefft BJ, Uthamaraj S, Harburn JJ, Klabusay M, Hlinomaz O, Holmes DJ, Simari RD, Dragomir-Daescu D, Sandhu GS, Novel duplex steel stent enables nanoparticle mediated cell capture and demonstrates endothelialization at three days, American Heart Association 2013, Dallas, TX, 11/2013
Tefft BJ, Uthamaraj S, Hlinomaz O, Kalra M, Lerman A, Dragomir-Daescu D, Sandhu GS, Rapidly endothelializing vascular stent-grafts and grafts for soldiers unable to take anti-platelet agents due to bleeding risk, Military Health Systems Research Symposium 2016, Kissimmee, FL, 08/2016
Tefft BJ, Spoon DB, Hennessy RS, Stoyles NJ, Young MD, Jana S, Dragomir-Daescu D, Simari RD, Lerman A, Cardiac valve bioreactor capable of physiological conditioning, Biomedical Engineering Society 2016, Minneapolis, MM, 10/2016
 
International
Tefft BJ, Gooden JY, Uthamaraj S, Harburn JJ, Holmes DJ, Simari RD, Dragomir-Daescu D, Sandhu GS, Magnetizable duplex steel stents enable endothelial cell capture, Scientific and Clinical Applications of Magnetic Carriers 2012, Minneapolis, MN, 05/2012
Uthamaraj S, Tefft BJ, Sandhu GS, Dragomir-Daescu D, Ferromagnetic stent-graft for rapid endothelial cell capture, International Academy of Cardiology 2015, Vancouver, BC, Canada, 06/2015
Tefft BJ, Uthamaraj S, Harburn JJ, Hlinomaz O, Lerman A, Dragomir-Daescu D, Sandhu GS, Magnetizable stent-grafts enable endothelial cell capture, Scientific and Clinical Applications of Magnetic Carriers 2016, Vancouver, BC, Canada, 05/2016
 

COMMITTEE SERVICE:
Medical College
05/2018 - Present Member, Undergraduate Committee, Biomedical Engineering, Medical College of Wisconsin & Marquette University
06/2018 - Present Department Representative Alternate, Faculty Council, Medical College of Wisconsin
 

EXTRAMURAL TEACHING:
Community/Lay Public
10/2017 Mayo Clinic, Lecture on Exploring the Body’s Building Blocks for Regenerative Medicine Minnesota course
 
Medical Student Education
04/2015 Mayo Clinic, Lecture on 3D-Bioprinting for Regenerative Medicine and Surgery selective course
04/2016 Mayo Clinic, Lecture on 3D-Bioprinting for Regenerative Medicine and Surgery selective course
04/2017 Mayo Clinic, Lecture on 3D-Bioprinting for Regenerative Medicine and Surgery selective course
 
Continuing Medical Education
02/2015 Mayo Clinic, Faculty for Collaborative 3D-Printing in Medical Practice course
 
Graduate Student Education
04/2008 - 06/2008 Northwestern University, Teaching Assistant for Tissue Engineering course
06/2015 Mayo Clinic, Lecture for Regenerative Medicine course
 

MCW STUDENTS, FACULTY, RESIDENTS AND CLINICAL/RESEARCH FELLOWS MENTORED:
Undergraduate Students
Harsimran Kalsi, Medical College of Wisconsin, 06/2018 - 08/2018 summer research mentor (CTSI 500 Stars program)
Pedro Lopez, Medical College of Wisconsin, 07/2018 - Present research mentor
Matthew Kunze, Medical College of Wisconsin, 07/2018 - Present research mentor
 
Graduate Students
PhD Students Advised
Shayan Shafiee, Medical College of Wisconsin, 08/2018 - Present
 


BIBLIOGRAPHY
Refereed Journal Publications/Original Papers
1. Liu SQ, Alkema PK, Tieché C, Tefft BJ, Liu DZ, Li YC, Sumpio BE, Caprini JA, Paniagua M. Negative regulation of monocyte adhesion to arterial elastic laminae by signal regulatory protein alpha and Src homology 2 domain-containing protein-tyrosine phosphatase-1. J Biol Chem. 2005 Nov 25;280(47):39294-301.
2. Tefft BJ, Tefft JA. Galilean relativity and the work-kinetic energy principle The Physics Teacher. 45(4):218-220.
3. Liu SQ, Tefft BJ, Zhang A, Zhang LQ, Wu YH. Formation of smooth muscle alpha actin filaments in CD34+ bone marrow cells on arterial elastic laminae: potential role of SH2 domain-containing protein tyrosine phosphatase-1. Matrix Biol. 2008 May;27(4):282-94.
4. Liu SQ, Teft BJ, Zhang LQ, Li YC, Wu YH. Elastic laminae in vascular development and disease. Mol Cell Biomech. 2010 Jun;7(2):59-76.
5. Tefft BJ, Kopacz AM, Liu WK, Liu SQ. Enhancing endothelial cell retention on ePTFE constructs by siRNA-mediated SHP-1 gene silencing Journal of Nanotechnology in Engineering and Medicine. 2(1):0110071-0110076.
6. Liu SQ, Tefft BJ, Zhang L, Liu C, Wu YH. Regulation of hepatic cell mobilization in experimental myocardial ischemia Cellular and Molecular Bioengineering. 4(4):693-707.
7. Liu SQ, Tefft BJ, Dong B. Liver-mediated myocardial protection in experimental myocardial infarction Journal of Clinical & Experimental Cardiology. S7:002.
8. Liu SQ, Tefft BJ, Zhang D, Roberts D, Schuster DJ, Wu A. Cardioprotective mechanisms activated in response to myocardial ischemia. Mol Cell Biomech. 2011 Dec;8(4):319-38.
9. Liu SQ, Tefft BJ, Roberts DT, Zhang LQ, Ren Y, Li YC, Huang Y, Zhang D, Phillips HR, Wu YH. Cardioprotective proteins upregulated in the liver in response to experimental myocardial ischemia. Am J Physiol Heart Circ Physiol. 2012 Dec 15;303(12):H1446-58.
10. Tefft BJ, Gooden JY, Uthamaraj S, Harburn JJ, Klabusay M, Holmes DR, Simari RD, Dragomir-Daescu D, Sandhu GS. Magnetizable duplex steel stents enable endothelial cell capture IEEE Transactions on Magnetics. 49(1):463-466.
11. Spoon DB, Tefft BJ, Lerman A, Simari RD. Challenges of biological valve development Interventional Cardiology. 5(3):319-334.
12. Tefft BJ, Kopacz AM, Liu WK, Liu SQ. Experimental and computational validation of Hele-Shaw stagnation flow with varying shear stress Computational Mechanics. 52(6):1463-1473.
13. Jana S, Tefft BJ, Spoon DB, Simari RD. Scaffolds for tissue engineering of cardiac valves. Acta Biomater. 2014 Jul;10(7):2877-93.
14. Uthamaraj S, Tefft BJ, Klabusay M, Hlinomaz O, Sandhu GS, Dragomir-Daescu D. Design and validation of a novel ferromagnetic bare metal stent capable of capturing and retaining endothelial cells. Ann Biomed Eng. 2014 Dec;42(12):2416-24.
15. Tefft BJ, Kopacz AM, Liu WK, Liu SQ. Enhancement of endothelial cell retention on vascular constructs by siRNA-mediated SHP-1 or SHP-2 gene silencing Cellular and Molecular Bioengineering. 8(3):507-516.
16. Uthamaraj S, Tefft BJ, Hlinomaz O, Sandhu GS, Dragomir-Daescu D. Ferromagnetic Bare Metal Stent for Endothelial Cell Capture and Retention. J Vis Exp. 2015 Sep 18(103). PMCID: PMC4692619
17. Helder MR, Hennessy RS, Spoon DB, Tefft BJ, Witt TA, Marler RJ, Pislaru SV, Simari RD, Stulak JM, Lerman A. Low-Dose Gamma Irradiation of Decellularized Heart Valves Results in Tissue Injury In Vitro and In Vivo. Ann Thorac Surg. 2016 Feb;101(2):667-74. PMCID: PMC5341747
18. Tefft BJ, Uthamaraj S, Harburn JJ, Klabusay M, Dragomir-Daescu D, Sandhu GS. Cell Labeling and Targeting with Superparamagnetic Iron Oxide Nanoparticles. J Vis Exp. 2015 Oct 19(105):e53099. PMCID: PMC4692653
19. Uthamaraj S, Tefft BJ, Jana S, Hlinomaz O, Kalra M, Lerman A, Dragomir-Daescu D, Sandhu GS. Fabrication of Small Caliber Stent-grafts Using Electrospinning and Balloon Expandable Bare Metal Stents. J Vis Exp. 2016 10 26(116). PMCID: PMC5092244
20. Tefft BJ, Uthamaraj S, Harburn JJ, Hlinomaz O, Lerman A, Dragomir-Daescu D, Sandhu GS. Magnetizable stent-grafts enable endothelial cell capture. J Magn Magn Mater. 2017 Apr 01;427:100-104. PMCID: PMC5341609
21. Hennessy RS, Jana S, Tefft BJ, Helder MR, Young MD, Hennessy RR, Stoyles NJ, Lerman A. Supercritical carbon dioxide-based sterilization of decellularized heart valves. JACC Basic Transl Sci. 2017 Feb;2(1):71-84. PMCID: PMC5358672
22. Helder MRK, Stoyles NJ, Tefft BJ, Hennessy RS, Hennessy RRC, Dyer R, Witt T, Simari RD, Lerman A. Xenoantigenicity of porcine decellularized valves. J Cardiothorac Surg. 2017 Jul 17;12(1):56. PMCID: PMC5514525
23. Hennessy RS, Go JL, Hennessy RR, Tefft BJ, Jana S, Stoyles NJ, Al-Hijji MA, Thaden JJ, Pislaru SV, Simari RD, Stulak JM, Young MD, Lerman A. Recellularization of a novel off-the-shelf valve following xenogenic implantation into the right ventricular outflow tract. PLoS One. 2017;12(8):e0181614. PMCID: PMC5538661
24. Tefft BJ, Uthamaraj S, Harbuzariu A, Harburn JJ, Witt TA, Newman B, Psaltis PJ, Hlinomaz O, Holmes DR Jr, Gulati R, Simari RD, Dragomir-Daescu D, Sandhu GS. Nanoparticle-Mediated Cell Capture Enables Rapid Endothelialization of a Novel Bare Metal Stent. Tissue Eng Part A. 2018 07;24(13-14):1157-1166. PMCID: PMC6033300
25. Choe JA, Jana S, Tefft BJ, Hennessy RS, Go J, Morse D, Lerman A, Young MD. Biomaterial characterization of off-the-shelf decellularized porcine pericardial tissue for use in prosthetic valvular applications. J Tissue Eng Regen Med. 2018 Jul;12(7):1608-1620. PMCID: PMC6055610
26. Tefft BJ, Choe JA, Young MD, Hennessy RS, Morse DW, Bouchard JA, Hedberg HJ, Consiglio JF, Dragomir-Daescu D, Simari RD, Lerman A. Cardiac Valve Bioreactor for Physiological Conditioning and Hydrodynamic Performance Assessment. Cardiovasc Eng Technol. 2018 Oct 11.
 
Abstracts
1. Tefft BJ, Jana S, Young MD, Hennessy RS, Stoyles NJ, Lerman A (2016). Novel techniques for electrospinning transcatheter and surgical cardiac valve prostheses with potential for endothelialization and durability. Tissue Engineering Part A. 22(1 suppl):S52-S52. Abstract no. 194.
2. Tefft BJ, Uthamaraj S, Harburn JJ, Dragomir-Daescu D, Sandhu GS (2015). Nanotechnology enabled endothelialization of stent-grafts. European Heart Journal. 36(1 suppl):384-384. Abstract no. P2375.
3. Uthamaraj S, Tefft BJ, Sandhu GS, Dragomir-Daescu D (2015). Ferromagnetic stent-graft for rapid endothelial cell capture. Cardiology. 131(2 suppl):38-38. Abstract no. 026.
4. Tefft BJ, Uthamaraj S, Harburn JJ, Klabusay M, Hlinomaz O, Holmes DJ, Simari RD, Dragomir-Daescu D, Sandhu GS (2013). Novel duplex steel stent enables nanoparticle mediated cell capture and demonstrates endothelialization at three days. Circulation. 128(22 suppl). Abstract no. 17962.
5. Kopacz AM, Tefft BJ, Liu SQ, Liu WK (2010). Modeling of cell adhesion dynamics modulated by molecular engineering. Proceedings of ASME2010 First Global Congress on NanoEngineering for Medicine and Biology. 313-314.
6. Tefft BJ, Kopacz AM, Liu WK, Liu SQ (2010). Knockdown of SHP-1 enhances endothelial cell retention for vascular regeneration. Proceedings of ASME2010 First Global Congress on NanoEngineering for Medicine and Biology. 351-352.
7. Liu SQ, Tefft BJ, Tieche C, Alkema PK, Wu YH (2006). Formation of smooth muscle alpha actin filaments in CD34+ bone marrow cells. Circulation 114(18 suppl): 216-216. Abstract no. 1158.
8. Liu SQ, Tefft BJ, Tieche C, Alkema PK, Hoshi R, Wu YH (2006). Molecular basis for the anti-inflammatory effect of arterial elastic laminae. Experimental Biology 2006 Meeting. FASEB Journal. 20(4):A413-A413.
9. Liu SQ, Tefft BJ, Tieche C, Alkema PK, Hoshi R, Zhang LQ, Wu YH (2006). Formation of smooth muscle alpha actin filaments in CD34+ bone marrow cells in elastic lamina-containing matrix. Experimental Biology 2006 Meeting. FASEB Journal 20(4): A405-A405.
 
Patents
1. Tefft BJ, Spoon DB, Sandhu GS (2013). Devices and methods for self-centering a guide catheter. USA #9,889,006 B2.
2. Tefft BJ, Dragomir-Daescu D, Sandhu GS, Uthamaraj S (2014). Devices and methods for endothelialization of magnetic vascular grafts. USA #PCT/US2015/029695. Application filed.
3. Tefft BJ, Dragomir-Daescu D, Sandhu GS, Uthamaraj S (2014). Devices and methods for forming stents in vivo. USA #PCT/US2015/029713. Application filed.
4. Tefft BJ, Spoon DB, Sandhu GS, McGowan RW, Haverkost PA, Groff JN, Radman L, Ross D (2016). Self-centering guide catheter. USA #PCT/US2017/020462. Application filed.
5. Tefft BJ, Spoon DB, Sandhu GS, McGowan RW, Haverkost PA, Groff JN, Radman L, Ross D (2017). Emboli-capturing centering device. USA #PCT/US2018/026004. Application filed.
 

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