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CURRICULUM VITAE

Calvin B. Williams MD, PhD
Chief, Professor
Department of Pediatrics
Division of Rheumatology

OFFICE ADDRESS:
Children's Corporate Center
999 N 92 St
Milwaukee, WI 53226

EDUCATION:
1978 - 1983 BA, California State University, Fullerton, CA
1983 - 1991 MD, University of California, Irvine, CA
1983 - 1991 PhD, University of California, Irvine, CA

POSTGRADUATE TRAINING AND FELLOWSHIP APPOINTMENTS:
1991 - 1992 Intern in Pediatrics, St. Louis Children’s Hospital, St. Louis, MO
1992 - 1993 Junior Pediatric Resident, St. Louis Children’s Hospital, St. Louis, MO
1993 - 1994 Clinical Fellow in Pediatric Immunology and Rheumatology, Dept. of Pediatrics, Washington University School of Medicine, St. Louis, MO
1994 - 1996 Research Fellow in Pediatric Immunology and Rheumatology, Center for Immunology, Washington University School of Medicine, St. Louis, MO
1996 - 1999 Postdoctoral fellow, Washington University School of Medicine, St. Louis, MO

FACULTY APPOINTMENTS:
1996 Instructor in Pediatrics, Washington University School of Medicine, St. Louis, MO
1998 Assistant Professor of Pediatrics, Washington University School of Medicine, St. Louis, MO
2002 Associate Professor of Pediatrics, Medical College of Wisconsin, Milwaukee, WI
2003 - Present Associate Professor of Microbiology and Molecular Genetics, Medical College of Wisconsin, Milwaukee, WI
2011 - Present Professor of Pediatrics, Microbiology and Molecular Genetics, Microbiology and Molecular Genetics, Milwaukee, WI

ADMINISTRATIVE APPOINTMENTS:
2002 - Present Chair, Rheumatology, D.B and Marjorie Reinhart Family Foundation
2002 - Present Section Chief, Pediatric Rheumatology, Medical College of Wisconsin, Milwaukee, WI

EDUCATIONAL ADMINISTRATIVE APPOINTMENTS:
2003 - 2013 Director, Pediatric Rheumatology Fellowship Training Program, Medical College of Wisconsin, Milwaukee, WI
2011 - Present Associate Director Medical Scientist Training Program, Medical College of Wisconsin, WI 53226

HOSPITAL AND CLINICAL ADMINISTRATIVE APPOINTMENTS:
1997 - 2000 1997-2000 Director, Rheumatology Service, Shriner’s Hospital for Children, St. Louis, MO

RESEARCH ADMINISTRATIVE APPOINTMENTS:
1996 - Present NIH-funded Principle Investigator
2008 - Present Associate Director, Children’s Research Institute, Children’s Hospital of Wisconsin, Milwaukee, WI
2012 - 2013 Interim Chief Scientific Officer, Children's Hospital of Wisconsin Research Institute, WI 53226
2012 - Present Associate Dean of Research, Medical College of Wisconsin, Milwaukee, WI 53226
2013 - Present Vice Chair for Research, Department of Pediatrics, Medical College of Wisconsin, WI 53226
2013 - Present Chief Scientific Officer, Children's Hospital of Wisconsin Research Institute, WI 53226

HOSPITAL STAFF PRIVILEGES:
1996 - 2002 St. Louis Children’s Hospital, St. Louis, MO
1997 - 2002 Shriner’s Hospital for Children, St. Louis, MO
2002 - Present Children’s Hospital of Wisconsin, Milwaukee, WI

SPECIALTY BOARDS AND CERTIFICATION:
Board Certified
Issue DateExpiration
American Board of Pediatrics
10/1998
10/2005
American Board of Pediatrics – Sub-board in Pediatric Rheumatology
11/2000
11/2007
American Board of Pediatrics – Sub-board in Pediatric Rheumatology Recertified
11/2008
11/2014
 
Licensure
Number Issue DateExpiration
Missouri License
108030
01/1995
01/2004
Wisconsin License
44530-020
05/2002
10/2011
Illinois License
026-107992
07/2002
07/2008
 

AWARDS AND HONORS:
1982 - Present Summer Fellowship, California Foundation for Biochemical Research
1989 - Present Earl C. Anthony Dissertation Fellowship
1990 - Present 1990 MRES Medical Scientist Student Scholarship
1992 - Present Vincent P. Carroll Jr., Memorial Research Award for Outstanding Research
1997 - Present Scholar of the Center for Child Health Research at Washington University
1999 - Present Basil O’Connor Research Award, March of Dimes
2002 - Present D.B. and Marjorie Reinhart Family Foundation Chair in Pediatric Rheumatology
2004 - Present Outstanding Health Professional Award , Wisconsin Chapter of the Arthritis Foundation
2010 - Present Best Doctors in America, Woodward/Wite Inc., Aiken, SC

MEMBERSHIPS IN HONORARY AND PROFESSIONAL SOCIETIES:
2001 - Present American Association of Immunologists (Member)
2001 - Present American College of Rheumatology (Member)
2002 - Present Childhood Arthritis & Rheumatology Research Alliance (Member)
2003 - Present Society for Pediatric Research (Member)

EDITORSHIPS/EDITORIAL BOARDS/JOURNAL REVIEWS:
Journal Review
2005 - Present Blood
2006 - Present Journal of Immunology
2008 - Present Pediatric Research

LOCAL/REGIONAL APPOINTED LEADERSHIP AND COMMITTEE POSITIONS:
2003 - Present founding member, Committee on Immunology, Medical College of Wisconsin, Milwaukee, WI
2004 - 2007 Member, Board of Directors, Arthritis Foundation, Wisconsin Chapter
2004 - Present Member, Board of Directors, Lupus Foundation of America, Wisconsin Chapter
2008 - Present Chair, Committee on Immunology, Medical College of Wisconsin, Milwaukee, WI
2008 - Present Ad Hoc Reviewer, Advancing a Healthier Wisconsin, Medical College of Wisconsin

NATIONAL ELECTED/APPOINTED LEADERSHIP AND COMMITTEE POSITIONS:
2008 - Present Abstract Reviewer, Annual Scientific Meeting, American College of Rheumatology
2009 - Present Ad Hoc Grant Reviewer, Netherlands Organization for Scientific Research
2009 - Present Ad Hoc Grant Reviewer, Health Research Board of Ireland

RESEARCH GRANTS/AWARDS/CONTRACTS/PROJECTS:
Active
Peer Review
Title:
Mechanisms of disease pathogenesis in regulatory T cell deficiency
Source:
NIH NIAID R01 AI085090-01
Role:
Principal Investigator
PI:
Multiple PI with Talal A Chatila
Dates:
12/10/2009 - 05/31/2015
Direct Funds:
$1,250,000 (CBW $625,000)
 
Title:
Regulatory T cell populations in graft versus host disease
Source:
NIH NHLBI HL064603
Role:
Co-investigator
PI:
William Drobyski
Dates:
05/27/2013 - 07/31/2017
Direct Funds:
$1,190,000 (CBW $100,000)
 
Title:
In vivo control of induced regulatory T cell differentiation and function
Source:
Crohn's and Colitis Foundation
Role:
Principal Investigator
Dates:
01/01/2014 - 12/31/2016
Direct Funds:
$315,900
 
Title:
Platelet-derived FVIII gene therapy of Hemophilia A
Source:
NIH NHLBI 2R01 HL102045-06
Role:
Co-investigator
PI:
Qizhen Shi
Dates:
05/01/2015 - 04/30/2019
Direct Funds:
$1,250,000 (CBW $100,000)
 
Non-Peer Review
Title:
Regulatory T cell development and function
Source:
Children’s Hospital of Wisconsin endowed chair
Role:
Principal Investigator
PI:
Self
Dates:
01/01/2004 - Present
Direct Funds:
$504,649 ((total for all years to date))
 
Prior
Peer Review
Title:
Mechanism of T Cell Tolerance
Source:
NIH NIAMS K08 AR01998
Role:
Principal Investigator
PI:
Self
Dates:
08/01/1996 - 07/31/2000
Direct Funds:
$325,852
 
Title:
Lymphocyte Selection in the Developing Immune System
Source:
March of Dimes Basil O’Connor Research Award
Role:
Principal Investigator
PI:
Self
Dates:
02/01/1999 - 01/31/2001
Direct Funds:
$90,908
 
Title:
Selection and Survival of T Lymphocytes
Source:
NIH NIAID RO1 AI47154
Role:
Principal Investigator
PI:
Self
Dates:
08/01/2000 - 05/31/2005
Direct Funds:
$1,000,000
 
Title:
Gene Expression in Pediatric Arthritis
Source:
NIH, Subcontract
Role:
Co-Investigator
PI:
Colbert, Cincinnati
Dates:
07/01/2003 - 06/30/2009
Direct Funds:
$189,650
 
Title:
Meaningful Outcome Measures for Pediatric Lupus Trials
Source:
NIH-RO1 AR051868-01 Subcontract
Role:
Co-Investigator
PI:
Brunner, Cincinnati
Dates:
04/01/2005 - 06/30/2008
Direct Funds:
$46,911
 
Title:
Triptorelin for Ovary Protection in childhood onset lupus
Source:
FDA, Subcontract (PI – Brunner, Cincinnati)
Role:
Site Principal Investigator
PI:
Self
Dates:
09/30/2005 - 09/29/2007
Direct Funds:
$17,124
 
Title:
Generation and decay of memory T cells in children with juvenile rheumatoid arthritis
Source:
NIH NIAID NO1-A1-50032 (PD-Gorski, Blood Research Institute)
Role:
Project Principal Investigator (objectives 1 - 4)
PI:
Self
Dates:
09/30/2005 - Present
Direct Funds:
$1,243,604 (total for all years - objectives 1 - 4)
 
Title:
Towards Biomarkers for Lupus Renal Disease
Source:
Alliance for Lupus Research Subcontract
Role:
Co-Investigator
PI:
Dr. Brunner, Cincinnati
Dates:
03/2006 - 05/2009
Direct Funds:
$23,236
 
Title:
Lymphocyte Selection in the Developing Immune System
Source:
March of Dimes
Role:
Principal Investigator
PI:
Self
Dates:
06/01/2007 - 05/31/2004
Direct Funds:
$229,847
 
Title:
The role of induced regulatory T cells in dominant immunologic tolerance
Source:
Advancing a Healthier Wisconsin Initiative
Role:
Principal Investigator
PI:
Self
Dates:
07/01/2008 - 06/30/2011
Direct Funds:
$130,000
 
Title:
Macrophage Activation Syndrome Biomarkers in Systemic Juvenile Idiopathic Arthritis
Source:
Subcontract on NIH-NIAMS-2P60AR047784-06A2 (Grom PI)
Role:
Co-Investigator
Dates:
08/18/2008 - 07/31/2013
 
Title:
Multidisciplinary clinical research centers: Improved understanding of the biology and use of the TNF inhibition in JRA
Source:
Subcontract on NIH-NIAMS-2P60AAR047784-06A2 (PI-Lovell, Cincinnati)
Role:
Co-Investigator
Dates:
08/18/2008 - 07/31/2013
 
Title:
Regulatory T cell selection and specificity
Source:
NIH NIAID R01 AI073731-01A2
Role:
Principal Investigator (dual PI award with Talal A. Chatila)
PI:
Self
Dates:
08/11/2009 - 07/31/2011
Direct Funds:
$500,000 ((total for all years, CBW $250,000, TAC $250,000))
 
Title:
Induced and natural regulatory T cells in the treatment of colitis
Source:
Crohn’s and Colitis Foundation of America
Role:
Principal Investigator
PI:
Self
Dates:
07/01/2010 - 06/30/2013
Direct Funds:
$243,000
 
Non-Peer Review
Title:
Open-label extension treatment with TNFR:Fc for participating patients in TNFR:Fc clinical trials
Source:
Immunex Corporation
Role:
Co-Investigator
Dates:
1998 - 2007
Direct Funds:
$36,108
 
Title:
Registry of etanercept (Enbrel) in children with juvenile rheumatoid arthritis
Source:
Immunex Corporation
Role:
Co-Investigator
Dates:
06/01/2001 - 05/2009
Direct Funds:
$45,000
 
Title:
A Phase III, Multi-Center, Multi-National, Randomized, Withdrawal Study to Evaluate the Safety and Efficacy of BMS-188667 in Children and Adolescents with Active Polyarticular JRA
Source:
Bristol-Myers Squibb
Role:
Co-Investigator
Dates:
05/12/2004 - 08/01/2007
Direct Funds:
$13,328
 
Title:
Mechanisms of disease pathogenesis in regulatory T cell deficiency
Source:
NIH NIAID R01 AI085090-01S1
Role:
Principal Investigator
PI:
Self
Dates:
07/01/2010 - 06/30/2011
Direct Funds:
$100,000 ((CBW $50,000, TAC $50,000))
 
Title:
Regulatory T cell selection and specificity
Source:
NIH NIAID R01 AI073731-01A2S1
Role:
Principal Investigator
PI:
Self
Dates:
07/11/2010 - 06/30/2011
Direct Funds:
$135,898 ((CBW $67,949, TAC $67,949))
 

INVITED LECTURES/WORKSHOPS/PRESENTATIONS:
Local
Selection and Maintenance of the T Cell Repertoire, Blood Center of SE Wisconsin, Blood Research Institute, Milwaukee, WI, 12/2002 - Present
Selection and Maintenance of the T Cell Repertoire, Department of Microbiology and Molecular Genetics, Medical College of Wisconsin, Milwaukee, WI, 01/28/2003 - Present
Juvenile Arthritis, Family Day Winter Fun Day – Sponsored by the Wisconsin Chapter of the Arthritis Foundation, Wisconsin Dells, WI, 01/2003 - Present
T Cell Receptor Antagonism: A Potential Therapy for Autoimmune Disease?, Department of Pediatrics Research Conference, Medical College of Wisconsin, Milwaukee, WI, 02/21/2003 - Present
Pediatric Lupus, Lupus Education Day – Sponsored by the Lupus Foundation, Children’s Hospital of Wisconsin, Milwaukee, WI, 05/10/2003 - Present
Childhood Arthritis, 2003, More Life Less Limits - Wisconsin Chapter Annual Meeting– Sponsored by the Wisconsin Chapter of the Arthritis Foundation. Wisconsin Athletic Club, Milwaukee, WI, 05/2003 - Present
Research in Pediatric Rheumatology, CHW Foundation All Staff Meeting, Oakwood Bldg. – Research Park, 06/18/2003 - Present
Lupus in Children, Lupus Foundation of America, Wisconsin Chapter, Inc. Medical Symposium, Froedtert Memorial Lutheran Hospital, Milwaukee, WI, 10/18/2003 - Present
Selection and Maintenance of the T Cell Repertoire, Biomedical Resource Center, Medical College of Wisconsin, Milwaukee, WI, 12/2004 - Present
Regulatory T Cell Control of Immune Responses, Department of Pediatrics Research Conference, Medical College of Wisconsin, Milwaukee, WI, 07/2006 - Present
The Role of Foxp3 in Regulatory T Cell Development, Children’s Research Institute Annual Symposium, Children’s Hospital of Wisconsin, Milwaukee, WI, 04/2008 - Present
Training Grant in Immunology, Department of Pediatrics, Section Chief Retreat, Medical College of Wisconsin, Milwaukee, WI, 08/2008 - Present
The Requisite Role of Induced Regulatory T Cells in Immunologic Tolerance, Children’s Research Institute Research Conference, Children’s Hospital of Wisconsin, Milwaukee, WI, 11/2009 - Present
The Requisite Role of Induced Regulatory T Cells in Immunologic Tolerance, Allergy and Immunology Grand Rounds, Medical College of Wisconsin, Milwaukee, WI, 04/2010 - Present
 
Regional
Systemic Lupus Erythematosus, Clinical Case Conference, Department of Pediatrics, Washington University School of Medicine, St. Louis, MO, 10/21/1997 - Present
The role of Self Peptides in T Cell Development and Tolerance, Research Retreat, Department of Pediatrics, Washington University School of Medicine, St. Louis, MO, 03/14/1998 - Present
Horror Autotoxicus, Grand Rounds, Department of Pediatrics, Washington University School of Medicine, St. Louis, MO, 06/19/1998 - Present
Pediatric Rheumatology: Juvenile Rheumatoid Arthritis, Early Bird Rounds, Department of Pediatrics, Washington University School of Medicine, St. Louis, MO, 12/11/1998 - Present
Thymocyte Selection in the Developing Immune System, Work-in-progress, Department of Pediatrics, Washington University School of Medicine, St. Louis, MO, 11/08/2000 - Present
X-linked Severe Combined Immunodeficiency, Clinical Case Conference, Department of Pediatrics, Washington University School of Medicine, St. Louis, MO, 11/28/2000 - Present
The Selection and Survival of T Lymphocytes, Work-in-progress, Department of Pediatrics, Washington University School of Medicine, St. Louis, MO, 04/24/2002 - Present
Pediatric Autoimmune Disease: Mechanisms and Therapy, Grand Rounds, Department of Pediatrics, Washington University School of Medicine, St. Louis, MO, 05/24/2002 - Present
Chronic Arthritis in Children, Pediatric Grand Rounds – St. Therese Medical Center, Waukegan, IL, 10/2004 - Present
Juvenile Idiopathic Arthritis, Pediatric Grand Rounds, Condell Medical Center, Libertyville, IL, 05/2008 - Present
 
International
Systemic Lupus Erythematosus in Children, Polish-American Pediatric Conference, Rzeszow, Poland, 05/2010 - Present
Juvenile Ideopathic Arthritis, Polish-American Pediatric Conference, Rzeszow, Poland, 05/2010 - Present
 

PEER REVIEWED WORKSHOPS/PRESENTATIONS:
Local
Altered Peptide Ligands Affect T Cell Development and Tolerance, Annual Retreat, Washington University Immunology Program, Washington University School of Medicine, St. Louis, MO, 02/20/1998 - Present
An Essential Role for Induced Regulatory T Cells in Dominant Tolerance, Immunology Research Symposium, University of Wisconsin-Madison, 05/2000 - Present
 
National
An endogenously expressed T cell receptor antagonist inhibits T cell proliferation and the formation of T cell memory, Podium Presentation, Pediatric Rheumatology 2003: Park City and Beyond, Snowmass, CO, 03/2003 - Present
Central Tolerance Fails in Dual Receptor T cells Resulting in an Autoimmune-Prone Phenotype in Mice, American College of Rheumatology Annual Scientific Meeting, San Antonio, TX, 11/2004 - Present
 
International
Altered Peptide Ligands Limit T Cell Selection and Repertoire Diversity, Mini-symposium. 12th International Congress of Immunology, Montreal, Canada, 07/2004 - Present
 

COMMITTEE SERVICE:
Medical College
2003 - Present Chair, Committee on Immunology, Medical College of Wisconsin
2004 - Present co-chair, Innovations Task Force, Pediatric Research, Medical College of Wisconsin
2006 - 2007 BRC Director, Search Committee, Medical College of Wisconsin
2006 - Present Member, Search Committee, BRI Immunology Faculty, Medical College of Wisconsin
 

MEDICAL COLLEGE TEACHING ACTIVITIES:
Resident and Fellow Education
1996 - Present Attending physician at WUSTL and MCW, responsible for teaching pediatric residents and pediatric rheumatology fellows 8-10 weeks per year.
 

EXTRAMURAL TEACHING:
Medical Student Education
1996 - 2002 St. Louis Children’s Hospital, St. Louis, MO, Attending Physician, General Pediatrics, General Pediatrics ward attending 4-6 weeks per year.
1996 - 2002 St. Louis Children’s Hospital, St. Louis, MO, Attending Physician, Pediatric Immunology/Rheumatology
1998 - 2002 Washington University School of Medicine, St. Louis, MO, Lecturer, Clinical Correlates in Immunology
2002 - Present Attending Physician, pediatric rheumatology service, responsible for teaching medical students on the general outpatient pediatrics rotation and on rheumatology elective 8-10 weeks per year.
2004 - Present Medical College of Wisconsin, Milwaukee, WI, Lecturer, Clinical Correlates in Immunologic Tolerance, Medical Microbiology
 
Resident and Fellow Education
2003 - Present Medical College of Wisconsin and the Children’s Hospital of Wisconsin, Milwaukee, WI, Director, Pediatric Rheumatology Fellowship Program. Responsibilities include recruitment, curriculum content, program development, scheduling, fellow evaluation, and mentorship/advice.
 
Continuing Medical Education
2009 - Present Organize and schedule the Children’s Research Institute weekly research seminar series. Duties include maintaining CME compliance and CME annual accreditation reports
 
Graduate Student Education
2004 - Present Medical College of Wisconsin, Milwaukee, WI, Lecturer, Cellular and Molecular Immunology (M&MG 05-234)
2010 - Present Medical College of Wisconsin, Milwaukee, WI, Course Director and lecturer, Immunological Tolerance (M&MG 05-265)
2010 - Present Course Director and lecturer, Developmental Immunology (M&MG 05-264), Medical College of Wisconsin, Milwaukee, WI
 
Postdoctoral Fellow Education
2004 - Present four MCW departments and the Blood Research Institute, Organize, schedule and run the weekly Immunology Work-in-progress meeting for the campus.
 

MCW STUDENTS, FACULTY, RESIDENTS AND CLINICAL/RESEARCH FELLOWS MENTORED:
Medical Students
Derrick Siebert, Medical College of Wisconsin, 2005 - Present Summer research student mentor
Drew Hietpas, Medical College of Wisconsin, 2006 - Present Summer research student mentor
Lance Relland, Medical College of Wisconsin, 2009 - 2011 Physician Scientist Pathway mentor
Elisabeth Sederberg, Medical College of Wisconsin, 2009 - Present Summer research student mentor
Elica Inagaki, Medical College of Wisconsin, 2010 - 2011 Physician Scientist Pathway mentor
 
Graduate Students
MS Students Advised
Louise Markey Pathway, Medical College of Wisconsin, 1998 - 2002
Robert Latek, Medical College of Wisconsin, 1998 - 2002
Holly L. Hanson, Medical College of Wisconsin, 1998 - 2002
Tom Rummel, Medical College of Wisconsin, 2003 - Present
Rebecca Moyer, Medical College of Wisconsin, 2004 - Present
Lance Relland, Medical College of Wisconsin, 2004 - Present
Suzan Salti, Medical College of Wisconsin, 2005 - Present
Sreemanti Basu, Medical College of Wisconsin, 2007 - Present
Erica Treslley-Schmitt, Medical College of Wisconsin, 2007 - Present
Daniel Sanfelippo, Medical College of Wisconsin, 2009 - Present
 
Clinical/Research Fellows
Andrew J. White MD, Medical College of Wisconsin, 1996 - 1999 Advisor (WUSTL)
Vidya Raman MD, Medical College of Wisconsin, 1999 Advisor (WUSTL)
Anthony R. French MD, Medical College of Wisconsin, 2000 - 2003 Advisor (WUSTL)
Fei F. Shih MD, Medical College of Wisconsin, 2000 - 2003 Advisor (WUSTL)
Diane Brown MD, Medical College of Wisconsin, 2001 - 2004 Advisor (WUSTL)
Sheetal Vora MD, Medical College of Wisconsin, 2005 - 2008 Advisor (MCW)
Eli Eisenstein MD, Medical College of Wisconsin, 2006 - 2008 Advisor (MCW)
Grant Syverson MD, Medical College of Wisconsin, 2008 - Present Advisor (MCW)
Dominic Co MD PhD, Medical College of Wisconsin, 2009 - Present Advisor (MCW)
Elizabeth Kessler MD, Medical College of Wisconsin, 2010 - Present Advisor (MCW)
 

EXTRAMURAL STUDENTS, FACULTY, RESIDENTS, AND CLINICAL/RESEARCH FELLOWS MENTORED:
Graduate Students
PhD Students Advised
Lance Relland, 07/2004 - 06/2009 “The role of Ligand Affinity in Regulatory T Cell Selection and Function”
Erica Treslley-Schmitt, 07/2008 - Present student
PhD Committees
Leah Shriver, 2004 - 2009
Amy Beres, 2009 - Present
Jamie Wieting, 2010 - Present
 
Postdoctoral Students
Dipica Haribhai DVM, 2001 - 2006 Research mentor
Merav Lidar MD, 2002 - 2004 Research mentor
Manoj K. Mishra PhD, 2002 - 2006 Research mentor
Eli M. Eisenstein MD, 2007 - 2008 Research mentor
Christopher G. Mayne PhD, 2009 - Present Research mentor
Dominic Co MD PhD, 2010 - Present Research mentor
 
Faculty
James Verbsky MD PhD, 2005 - Present Research mentor
Sheetal Vora MD, 2008 - Present Clinical mentor
Nita Salzman MD PhD, 2008 - Present Collaborator/mentor
Veronica Flood MD, 2008 - Present Mentor committee
 

PROGRAMMATIC DEVELOPMENTS:
Educational Programs
Fellow
2003 - Present Pediatric Rheumatology Fellowship Program
 
Research Programs
2003 - Present Committee on Immunology
Regulatory T Cell Biology
CRI Flow Cytometry Facility
 
Clinical Programs
2002 - Present Dr. Williams is the Section Chief of Pediatric Rheumatology
 
Community Programs
Dr. Williams and his nursing staff support the local chapter of the Arthritis foundation by attending the week-long Camp MASH every summer
 

COMMUNITY SERVICE ACTIVITIES:
2004 - 2007 Board of Directors, Arthritis Foundation, Wisconsin Chapter, Milwaukee, WI
2004 - Present Board of Directors, Lupus Foundation of America, Wisconsin Chapter, Milwaukee, WI
 


BIBLIOGRAPHY
Refereed Journal Publications/Original Papers
1. Williams, C.B. and Gutman, G.A. T cell receptor beta chain genes in the rat: Availability and pattern of utilization of variable gene segments differs from that in the mouse. J. Immunol. 142:1027-1035, 1989.
2. Chandy, K.G., Williams, C.B., Spencer, R.H., Aguilar, B., Ghanshani, S., Tempel, B.L. and Gutman, G.A. A family of three mouse potassium channel genes with intronless coding regions. Science 247:973-975, 1990.
3. Williams, C.B., Khurana, S. and Gutman, G.A. Duplication of T cell receptor alpha-chain variable gene segments in the rat. Immunogenetics 32:134-137, 1990.
4. Williams, C.B., Blankenhorn, E.P., Byrd, K.E., Levinson, G. and Gutman, G.A. Organization and nucleotide sequence of the rat T cell receptor beta-chain complex. J. Immunol. 146:4406-4413, 1991.
5. Blankenhorn, E.P., Smith, P.D., Williams, C.B., Gutman, G.A. Alleles of the rat T-cell receptor beta chain gene complex. Immunogenetics 35:324-331, 1992.
6. Vidal, K., Hsu, B., Williams, C.B., and Allen, P. Endogenous altered peptide ligands can affect peripheral T cell responses. J. Exp. Med. 183:1311-1321, 1996.
7. Williams, C.B., and Allen, P.M. The study of self-tolerance using murine hemoglobin as a model self antigen. CIBA Foundation Symposium N. 215 Immunological Tolerance. 1997, Pg. 41-46.
8. Williams, C.B., Vidal, K., Donermeyer, D., Peterson, D.A., White, J.M., Allen, P.M. In Vivo expression of a TCR antagonist: T cells escape central tolerance but are antagonized in the periphery. J. Immunol. 161:128-137, 1998.
9. Basu, D., Williams, C.B., and Allen, P.M. In vivo antagonism of a T cell response by an endogenously expressed ligand. Proc. Natl. Acad. Sci. USA 95:14332-14336, 1998.
10. Williams, C.B., Engle, D.L., Kersh, G.J., White, J.M., and Allen, P.M. A kinetic threshold between negative and positive selection based on the longevity of the TCR-ligand complex. J. Exp. Med. 189:1531-1544, 1999.
11. Plas, D.R., Williams, C.B., Kersh, G.J., White, L.S., White, J.M., Paust, S., Ulyanova, T., Allen, P.M. and Thomas, M.L. Cutting Edge: The tyrosine phosphatase SHP-1 regulates thymocyte positive selection. J. Immunol. 162:5680-5684, 1999.
12. Marcelino, J., Carpten, J.D., Suwairi, W.M., Gutierrez, O.M., Schwartz, S., Robbins, C., Sood, R., Makalowska, I., Baxevaris, A., Johnstone, B., Laxer, R.M., Zemel, L., Kim, C.A., Herd, J.K., Ihle, J., Williams, C.B., Johnson, M., Ramen, V., Alonso, L.G., Brunoni, D., Gerstein, A., Papadopoulos, N., Bahabri, S.A., Trent, J.M. and Warman, M.L. CACP, encoding a secreted proteoglycan, is mutated in camtodactyly-arthropathy-coxa vara-pericarditis syndrome. Nature Genetics 23:319-322, 1999.
13. Kersh, G.J., Engle, D.L., Williams, C.B. and Allen, P.M. Ligand-specific selection of MHC class II-restricted thymocytes in fetal thymic organ culture. J. Immunol. 164:5675-5682, 2000.
14. Raman, V., Blaeser. F., Ho, N., Engle, D.L., Williams, C.B., and Chatila, T.A. Requirement for CaMKIV/Gr in setting the thymocyte selection threshold. J. Immunol. 167:6270-6278, 2001.
15. Haribhai, D.H., Meyer, M., Engle, D., White, M. and Williams, C.B. A threshold for central T cell tolerance to an inducible serum protein J. Immunol. 170:3007-14, 2003.
16. Singh, J., Williams, C.B. and McAlister, W.H. Talo-patello-scaphoid osteolysis, synovitis and short fourth metacarpals in sisters: a new syndrome? Am. J. Med. Gen., 121A:118-125, 2003.
17. Haribhai, D., Edwards, B., Williams, M.L., Williams, C.B.: "Functional reprogramming of the primary immune response by T cell receptor antagonism". J. Exp. Med., 200(11):1371-1382, 2004.
18. Lin, W., Truong, N., Grossman, W.J., Haribhai, D., Williams, C.B., Wang, J., Martin, M.G., and Chatila, T.A. Allergic dysregulation and hyperimmunoglobulinemia E in Foxp3 mutant mice. J. Allergy Clin. Immunol. 116:1106-15, 2005.
19. Haribhai, D., Lin, W., Relland, L.M., Truong, N., *Chatila, T.A., and *Williams, C.B., Regulatory T cells dynamically control the primary immune response to foreign antigen. J. Immunol. 178:2961-2972, 2007. * corresponding authors
20. Lin, W. Haribhai, D., Relland, L.M., Truong, N., Carlson, M.R., *Williams, C.B., and *Chatila, T.A., Regulatory T cell development in the absence of a functional Foxp3 protein. Nature Immunol. 8:359-368, 2007. *corresponding authors
21. Schulteis, R.D., Chu, H., Dai, X. Chen, Y., Edwards, B., Haribhai, D., Williams, C.B., Malarkannan, S., Hessner, M.J., Glisic-Milosavljevic, S., Jana, S. Kerschen, E.J., Ghosh, S., Wang, D., 2, Kwitek, A.E., Lernmark, A., Gorski, J., and Weiler, H. Impaired survival of peripheral T cells, disrupted NK/NKT cell development, and liver failure in mice lacking gimap5. Blood 112:4905-4914, 2008.
22. Relland, L.M., Mishra, M.K., Haribhai, D., Edwards, B., Ziegelbauer, J., and Williams, C.B. Affinity-based selection of regulatory T cells occurs independent of agonist-mediated induction of Foxp3 expression. J. Immunol. 182:1341-1350, 2009. (Featured article: "In this Issue" section)
23. Haribhai, D., Lin, W., Edwards, B., Ziegelbauer, J., Salzman, N.H., Carlson, M.R., *Chatila, T.A., and *Williams, C.B. A central role for induced regulatory T cells in tolerance induction in experimental colitis. J. Immunol. 182:3461-3468, 2009. *corresponding authors
24. Eisenstein, E.M., and Williams, C.B. The Treg/Th17 cell balance: A new paradigm for autoimmunity. Pediatr. Res. 65:26R-31R, 2009.
25. Jana, S., Jailwala, P., Ehlenbach, S., Haribhai, D., Waukau, J., Glisic-Milosavljevic, S., Grossman, W.J., Verbsky, J. W., Wen, R., Wang, D., Williams, C.B., and Ghosh, S. The role of Smad3 and NFkB in the regulation of Foxp3 expression in effector cells. Eur. J. Immunol. 39:1-13, 2009. (Featured article: "In This Issue").
26. Salzman, N.H., Hung, K., Haribhai, D. Chu, H., Karlsson-Sjoberg, Amir, E, Teggatz, P., Barman, M., Hayward, M., Stoel, M., Sodergren, E., Bevins, C.L., Weinstock, G.M., Williams, C.B., and Bos, N.A. Enteric defensins are essential regulators of intestinal microbial ecology. Nature Immunol. 11: 76-82, 2010. (Featured article: "New and Views").
27. Fu, G., Chen, Y, Yu, M., Podd, A., Schuman, J., He, Y., Di, L., Y, Yassai, M., Haribhai, D., North, P.E., Gorski, J, Williams, C.B., Wang, D., Wen, R. Phospholipase C1 is essential for T-cell development, activation and tolerance. J. Exp. Med. 207:309-318, 2010.
28. Mayne, C.G., Spanier, J.A., Relland, L.M., Williams, C.B., and Hayes, C.E., 1,25-Dihydroxyvitamine D3 acts directly on the T lymphocyte vitamin D receptor to inhibit experimental autoimmune encephalomyelitis. Eur. J. Immunol. 41:822-832, 2011.
29. Eisenstein, E. M., Syverson, G.D., Vora, S.S., and Williams, C.B. Combination therapy with methotrexate and etanercept for refractory chronic recurrent multifocal osteomyelitis. J. Rheum. 38:782-783, 2011.
30. Haribhai, D., Williams J.B., Jia, S., Nickerson, D., Schmitt, E.G., Edwards, B., Ziegelbauer, J., Yassai, M. , Li, S., Relland, L.R., Wise, P.M., Chen, A., Zheng, Y., Simpson, P.M., Gorski, J., Salzman, N.H., Hessner, M.J., *Chatila, T.A., and *Williams, C.B. A requisite role for induced regulatory T cells in tolerance based on expanding antigen receptor diversity. Immunity (2011), DOI:10.1016/j.immuni.2011.03.029.
31. Ray A, Basu S, Williams CB, Salzman NH, Dittel BN. A novel IL-10-independent regulatory role for B cells in suppressing autoimmunity by maintenance of regulatory T cells via GITR ligand. J Immunol. 2012 Apr 01;188(7):3188-98. PMCID: PMC3311743
32. Bonacci B, Edwards B, Jia S, Williams CB, Hessner MJ, Gauld SB, Verbsky JW. Requirements for growth and IL-10 expression of highly purified human T regulatory cells. J Clin Immunol. 2012 Oct;32(5):1118-28. PMCID: PMC4271826
33. Chatila TA, Williams CB. Foxp3: shades of tolerance. Immunity. 2012 May 25;36(5):693-4. PMCID: PMC3868336
34. Jeschke JC, Williams CB. Editorial: Crossing the divide: a novel Cd8 enhancer with activity in CTLs and CD8αα+ dendritic cells. J Leukoc Biol. 2015 Apr;97(4):623-5.
35. Brunner HI, Silva CA, Reiff A, Higgins GC, Imundo L, Williams CB, Wallace CA, Aikawa NE, Nelson S, Klein-Gitelman MS, Rose SR. Randomized, double-blind, dose-escalation trial of triptorelin for ovary protection in childhood-onset systemic lupus erythematosus. Arthritis Rheumatol. 2015 May;67(5):1377-85. PMCID: PMC4414812
36. Chatila TA, Williams CB. Regulatory T cells: exosomes deliver tolerance. Immunity. 2014 Jul 17;41(1):3-5. PMCID: PMC4130330
37. Sreedharan R, Chen S, Miller M, Haribhai D, Williams CB, Van Why SK. Mice with an absent stress response are protected against ischemic renal injury. Kidney Int. 2014 Sep;86(3):515-24. PMCID: PMC4149847
38. Wu X, Schulte BC, Zhou Y, Haribhai D, Mackinnon AC, Plaza JA, Williams CB, Hwang ST. Depletion of M2-like tumor-associated macrophages delays cutaneous T-cell lymphoma development in vivo. J Invest Dermatol. 2014 Nov;134(11):2814-2822.
39. Williams CB, Chatila TA. Editorial: Optimizing iTreg differentiation: STATs in the balance. J Leukoc Biol. 2014 Feb;95(2):197-8.
40. Schmitt EG, Haribhai D, Jeschke JC, Co DO, Ziegelbauer J, Yan K, Iwakura Y, Mishra MK, Simpson P, Salzman NH, Williams CB. Chronic follicular bronchiolitis requires antigen-specific regulatory T cell control to prevent fatal disease progression. J Immunol. 2013 Dec 01;191(11):5460-76. PMCID: PMC3893829
41. Schmitt EG, Williams CB. Generation and function of induced regulatory T cells. Front Immunol. 2013;4:152. PMCID: PMC3685796
42. Mayne CG, Williams CB. Induced and natural regulatory T cells in the development of inflammatory bowel disease. Inflamm Bowel Dis. 2013 Jul;19(8):1772-88. PMCID: PMC3690174
43. Williams CB, Chatila TA. Fox family ties. Cell Res. 2013 Apr;23(4):452-4. PMCID: PMC3616439
44. Schmitt EG, Haribhai D, Williams JB, Aggarwal P, Jia S, Charbonnier LM, Yan K, Lorier R, Turner A, Ziegelbauer J, Georgiev P, Simpson P, Salzman NH, Hessner MJ, Broeckel U, Chatila TA, Williams CB. IL-10 produced by induced regulatory T cells (iTregs) controls colitis and pathogenic ex-iTregs during immunotherapy. J Immunol. 2012 Dec 15;189(12):5638-48. PMCID: PMC3537488
45. Relland LM, Williams JB, Relland GN, Haribhai D, Ziegelbauer J, Yassai M, Gorski J, Williams CB. The TCR repertoires of regulatory and conventional T cells specific for the same foreign antigen are distinct. J Immunol. 2012 Oct 01;189(7):3566-74. PMCID: PMC3538134
46. Beres AJ, Haribhai D, Chadwick AC, Gonyo PJ, Williams CB, Drobyski WR. CD8+ Foxp3+ regulatory T cells are induced during graft-versus-host disease and mitigate disease severity. J Immunol. 2012 Jul 01;189(1):464-74. PMCID: PMC3381996
 
Books, Chapters, and Reviews
1. Williams, C.B., The development of the immune system. Rudolph's Pediatrics, 21st edition, Rudolph, C.D., Rudolph A.M., Hostetter, M.K., Lister, G.E., and Siegel, N.J. editors, McGraw Hill Medical, New York, NY, 2003.
2. Williams, C.B. and Cole, F.S. Immunology of the Fetus and Newborn. Avery's Diseases of the Newborn, 8th edition, Taeusch, H.W., Ballard, R.A., Gleason, C.A., and Avery, M.E. editors, Elsevier Health Sciences, Philadelphia, PA, 2005.
3. Eisenstein, E.M. and Williams, C.B. The development of the immune system. Rudolph's Pediatrics, 22nd edition, Rudolph, C. D., Rudolph, A.M., Lister, G.E, First, L., and Gershon, A.A. editors, McGraw Hill Professional, New York, NY, 2011.
4. Williams, C.B. Eisenstein, E.M. and Cole, F.S. Immunology of the Fetus and Newborn. Avery's Diseases of the Newborn, 9th edition, Taeusch, H.W., Ballard, R.A., and Gleason, C.A., editors, Elsevier Health Sciences, Philadelphia PA (in press).
 
Abstracts
1. Haribhai, D., Meyer, M.M., and Williams, C.B., An endogenously expressed TCR antagonist inhibits T cell proliferation, B cell Help and the formation of T cell memory. 31st Annual Autumn Immunology Conference, Chicago, IL 2002.
2. Haribhai, D., Williams, M.L., Edwards, B. and Williams, C.B., T cell receptor antagonists induce tolerance by reprogramming the primary immune response. 32nd Annual Autumn Immunology Conference, Chicago, IL 2003.
3. Haribhai, D., Meyer, M.M., and Williams, C.B., Endogenous expression of a TCR antagonist inhibits antigen-specific T cell proliferation, secondary B cell follicle formation and T cell memory, Keystone Symposia: Mechanisms of Immunologic Tolerance and Its Breakdown (A2), Snowbird, UT 2003.
4. Haribhai, D., Meyers, M.M., and Williams, C.B., An endogenously expressed T cell receptor antagonist inhibits T cell proliferation and the formation of T cell memory. Pediatric Rheumatology 2003: Park City and Beyond, Snowmass, CO, 2003.
5. Lidar. M., Haribhai, D.H., and Williams, C.B., Central tolerance fails in dual receptor T cells resulting in an autoimmune-prone phenotype in mice. American College of Rheumatology 68th Annual Meeting, San Antonio TX 2004.
6. Haribhai, D., Williams, M.L., Edwards, B. and Williams, C.B., T cell receptor antagonists modulate homeostatic proliferation in lymphopenic hosts. 12th International Congress of Immunology, Montreal, Canada 2004.
7. Mishra, M.K. and Williams, C.B., Altered peptide ligands limit T cell selection and repertoire diversity. 12th International Congress of Immunology, Montreal, Canada 2004.
8. Haribhai, D., Williams, M.L., Edwards, B. and Williams, C.B., T cell receptor antagonists induce tolerance by reprogramming the primary immune response. Keystone Symposia: Lymphocyte Activation and Signaling (A3), Steamboat Springs, CO 2004.
9. Haribhai, D., Williams, M.L., Edwards, B., and Williams, C.B., T cell receptor antagonists induce tolerance by reprogramming the primary immune response. Pediatric Academic Societies' Annual Meeting, San Francisco, CA 2004.
10. Mishra, M.K. Haribhai, D., Relland, L.R., and Williams, C.B., Peripheral tolerance in a transgenic mouse model of pulmonary disease. 34th Annual Autumn Immunology Conference, Chicago IL 2005.
11. Haribhai, D., Ziegelbauer, J. Edwards, B., Williams, M.L., and Williams, C.B., Defining the relationship between TCR/ligand affinity and homeostatic expansion in lymphopenic hosts. Experimental Biology and the American Association of Immunologists Annual Meeting, San Diego CA 2005.
12. Haribhai, D., Ziegelbauer, J. Edwards, B., Williams, M.L., and Williams, C.B., Conversion of conventional T cells into Foxp3+ regulatory T cells requires agonist ligands and occurs in vivo. American Association of Immunologists Annual Meeting, Boston MA 2006.
13. Mishra, M.K. Haribhai, D., Relland, L.R., and Williams, C.B., Peripheral tolerance in a transgenic mouse model of pulmonary disease. American Association of Immunologists Annual Meeting, Boston MA 2006.
14. Relland, L.M., W. Lin, D. Haribhai, N. Truong, Chatila, T.A., and Williams, C.B. Visualizing regulatory T cell responses in vivo using a bicistronic Foxp3EGFP reporter allele. American Association of Immunologists Annual Meeting, Boston MA 2006.
15. Haribhai, D., Lin, W., Relland, L.M., Truong, N., Chatila, T.A., and Williams, C.B., Regulatory T cells dynamically control the immune response to foreign antigen. Keystone Symposia on Regulatory T Cells (B3), Vancouver, Canada 2007.
16. Relland, L.M., Haribhai, D., Mishra, M.K., and Williams, C.B., Agonists and Altered Peptide Ligands Fail to Promote Positive Selection of N3.L2 Natural Regulatory T Cells. Keystone Symposium on Regulatory T Cells (B3), Vancouver, Canada 2007.
17. Relland, L.M., Mishra, M.K., Haribhai, D., Edwards, B., Ziegelbauer, J., and Williams, C.B., Affinity-Based Selection of Regulatory T Cells Occurs Independent of Agonist-Mediated Induction of Foxp3 Expression. Keystone Symposium on Regulatory T Cells (C5), Keystone, CO 2009.
18. Haribhai, D., Lin, W., Edwards, B., Ziegelbauer, J., Salzman, N.H., Carlson, M.R., Chatila, T.A., and Williams, C.B., A central role for induced regulatory T cells in tolerance induction in experimental colitis. Keystone Symposium on Regulatory T cells (C5), Keystone CO 2009.
19. Treslley-Schmitt, E., Haribhai, D., Relland, L.R., and Williams, C.B., Characterization of a transgenic mouse model of lymphocytic interstitial pneumonitis. 38th Annual Autumn Immunology Conference, Chicago, IL 2009.
20. Relland, L.R., Williams, J.B., Haribhai, D., Yassai, M., Gorski, J., and Williams C.B. Antigen-specific regulatory and conventional T cells express distinct T cell receptor repertoires. 38th Annual Autumn Immunology Conference, Chicago, IL 2009.
21. Haribhai, D., Edwards, B., Ziegelbauer, J., Hessner, M., Chatila, T.A., and Williams, C.B., Induced regulatory T cells contribute to tolerance. 38th Annual Autumn Immunology Conference, Chicago, IL 2009.
 

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