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CURRICULUM VITAE

David D. Gutterman MD
Sr Associate Director, Professor
Department of Medicine
Division of Cardiology

OFFICE ADDRESS:
Medical Education Building
8701 Watertown Plank Rd
Milwaukee, WI 53226
Phone: 414-955-8595
Email: dgutt@mcw.edu

EDUCATION:
1972 - 1976 B.A., Mathematics and Chemistry, University of North Carolina, Chapel Hill
1976 - 1980 M.D., University of North Carolina, Chapel Hill

POSTGRADUATE TRAINING AND FELLOWSHIP APPOINTMENTS:
1980 - 1982 Resident, Internal Medicine, University of Iowa Hospitals and Clinics, Iowa City
1982 - 1983 Fellow, Cardiovascular Diseases, Department of Internal Medicine, University of Iowa Hospitals and Clinics, Iowa City
1983 - 1984 Chief Resident, Internal Medicine, University of Iowa Hospitals and Clinics, Iowa City
1984 - 1986 Fellow-Associate, Cardiovascular Diseases, Department of Internal Medicine, University of Iowa Hospitals and Clinics, Iowa City

FACULTY APPOINTMENTS:
1986 - 1987 Associate, Department of Internal Medicine, University of Iowa College of Medicine, Iowa City, Iowa
1987 - 1992 Assistant Professor, Department of Internal Medicine, University of Iowa College of Medicine, Iowa City, Iowa
1992 - 1998 Associate Professor, Department of Internal Medicine, University of Iowa College of Medicine, Iowa City, Iowa
1998 - Present Professor, Departments of Medicine and Physiology, Medical College of Wisconsin, Milwaukee, WI
1998 Professor, Department of Internal Medicine, University of Iowa College of Medicine, Iowa City
01/01/2000 - Present Northwestern Mutual Professor of Medicine, Departments of Internal Medicine and Physiology, Medical College of Wisconsin, Milwaukee, WI
07/01/2003 - Present Professor, Department of Pharmacology

ADMINISTRATIVE APPOINTMENTS:
07/01/2014 - Present Senior Associate Director, Cardiovascular Center

HOSPITAL STAFF PRIVILEGES:
1988 - 1998 Staff Physician, VA Medical Center, Iowa City, Iowa
1997 - 1998 Chief of Cardiology, VAMC, VA Medical Center, Iowa City, Iowa
1998 - Present Staff Cardiologist, VAMC, Milwaukee, WI
1998 - 2005 Associate Director, Cardiovascular Research Center, Medical College of Wisconsin, Milwaukee, WI
1998 - Present Physician, Froedtert Memorial Lutheran Hospital, Milwaukee, WI
1999 - 2005 Vice-Chair of Medicine for Research, Medical College of Wisconsin, Milwaukee, WI
2005 - 2014 Senior Associate Dean for Research, Medical College of Wisconsin, Milwaukee, WI
2014 - Present Senior Associate Director, Medicine, Cardiovascular Center, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226

SPECIALTY BOARDS AND CERTIFICATION:
Board Certified
Issue DateExpiration
American Board of Internal Medicine
06/1985
None
ABIM, Subspecialty Boards of Cardiovascular Diseases
11/1987
None
 
Licensure
Number Issue DateExpiration
North Carolina State
10261
05/1980
09/2015
Iowa State
22880
04/1982
09/2002
Wisconsin State
40328
09/1998
10/2015
 

AWARDS AND HONORS:
1973 - Present Gamma Alpha Lambda Sorority for Academic Honors, University of North Carolina
1974 - Present Phi Beta Kappa
1982 - Present Individual Research Fellowship
1984 - 1986 National Research Service Award
1986 - Present NHLBI Clinical Investigator Award
1992 - Present American Board of Internal Medicine, Invited Preparer of Questions for Recertification in Cardiovascular Diseases
2003 - Present Boron Lectureship, UCLA School of Medicine, Cardiology Division
2008 - Present Award for Most Significant Original Paper for 2008 in the category of Clinical Science published in Hypertension [ref: Phillips SA et al 2008]
2008 - Present George E. Brown Memorial Lectureship - American Heart Association Basic Cardiovascular Sciences Council
2010 - Present Award for Superior Editorial Consultant for Circulation Research
2012 - Present Named Top 5% of Reviewers for Chest for 2012, Chest
2013 - Present Carl J. Wiggers Lectureship , Cardiovascular Section of APS
2014 - Present Distinguished Service Award , Medical College of Wisconsin
2015 - Present Fellow, American Physiological Society
2015 - Present College Medalist Award , American College of Chest Physicians
2016 - Present Robert F. Furchgott Lecture , 2016 Mechanisms of Vasodilation Meeting
2017 - Present Michael Dunn Research Award, Department of Medicine, Medical College of Wisconsin
2018 - Present Gerristen Award , Microcirculatory Society / Microcirculation Journal
2018 - Present Distinguished Service Award , American College of Chest Physicians
2018 - Present Landis Award , Microcirculatory Society

MEMBERSHIPS IN HONORARY AND PROFESSIONAL SOCIETIES:
1983 - Present American Heart Association (Member)
1986 - Present American Federation for Clinical Research (Member)
1986 - Present American Physiological Society (Member)
1987 - 2002 Council on Basic Sciences (AHA) (Member)
1988 - Present American College of Cardiology (Fellow (FACC))
1988 - 2002 Council on Circulation (AHA) (Fellow)
1989 - Present Laennec Society (AHA) (Member)
1990 - Present Council on Clinical Cardiology (AHA) (Fellow)
1991 - Present Central Society for Clinical Research (Member)
1992 - Present American College of Chest Physicians (Fellow (FCCP))
1994 - Present American Heart Association, Council on High Blood Pressure (Fellow)
1994 - Present American Physiological Society (Fellow)
1996 - Present Microcirculatory Society (Member)
2001 - Present Fellow, American Heart Association (Council on Basic Cardiovascular Sciences)
2004 - Present Association of University Cardiologists (Elected Member)
2015 - Present American Physiological Society (Fellow)
2016 - Present North American Artery (Member)
2016 - Present North American Vascular Biology Organization (Member)

EDITORSHIPS/EDITORIAL BOARDS/JOURNAL REVIEWS:
Editorship
1999 - 2011 Associate Editor, American Journal of Physiology – Heart and Circulatory Physiology
2011 Associate Editor, CHEST
2011 - Present Consulting Editor, American Journal of Physiology – Heart and Circulatory Physiology
2016 - Present Board of Consulting Editors, Circulation Research
2018 - Present Associate Editor, American Journal of Physiology – Heart and Circulatory Physiology
Editorial Board
1993 - 1998 American Journal of Physiology - Heart and Circulatory Physiology
1995 - 1997 Circulation Research
2002 - Present Clinical Medicine & Research
2002 - Present Basic Research in Cardiology
2002 - Present Circulation Research
2003 - 2012 Atherosclerosis, Thrombosis, and Vascular Biology
2005 - 2010 Journal of the Cardio Metabolic Syndrome
2008 - Present International Advisory Board: Circulation Journal
2018 - Present FASEB BioAdvances
Journal Review
Nitric Oxide
Circulation
Molecular and Cellular Biochemistry
American Heart Journal
Developmental Neuroscience
Clinical and Experimental Pharmacology and Physiology
Chest
American Journal of Physiology
Journal of Applied Physiology
Hypertension
Clinical and Experimental Pharmacology and Physiology
Current Medicinal Chemistry
FASEB Journal
Free Radical Biology & Medicine
Journal of Molecular and Cellular Cardiology
Journal of Pharmacology and Experimental Therapeutics
New England Journal of Medicine
Journal of Neurochemistry
American Journal of Cardiology
Journal of Neurochemistry
Proceedings of the Society for Experimental Biology and Medicine
Nature Medicine
American Journal of Clinical Nutrition
Atherosclerosis, Thrombosis and Vascular Biology
Journal of Vascular Research
Journal of the American College of Cardiology

LOCAL/REGIONAL APPOINTED LEADERSHIP AND COMMITTEE POSITIONS:
1991 - 1998 Advisory Committee Member, Appropriations Committee, Senator Tom Harkin's Health and Human Services

NATIONAL ELECTED/APPOINTED LEADERSHIP AND COMMITTEE POSITIONS:
1988 - 1998 Member, (Iowa) Board of Directors, American Heart Association
1988 - 1991 Abstract Reviewer, AHA National Scientific Meeting, American Heart Association
1989 - 1990 Vice Chairman, AHA-I Research Committee, American Heart Association
1989 Co-Chair, Abstract Session, AHA National Scientific Sessions, American Heart Association
1990 - Present Chair, Abstract Session, American Physiological Society
1990 - 1992 Chairman, AHA-I Research Committee, American Heart Association
1990 Principal Organizer, Postgraduate Seminar "Advances in the Understanding of Neural Control of the Coronary Circulation,", American Heart Association
1991 - 1998 Member, AHA I Executive Committee, American Heart Association
1991 - 1994 Member, Western Consortium Peer Review Committee, American Heart Association
1991 - 1998 Advisory Committee Member, Senator Tom Harkin's Health and Human Services Appropriations Committee
1991 Member, American College of Cardiology Key Contact Program - Government Relations Committee
1991 - 1998 Member, Nominating Committee (AHA-I), American Heart Association
1992 Invited Preparer of Questions for Recertification in Cardiovascular Diseases, American Board of Internal Medicine
1992 Member, Melvin L. Marcus Young Investigator Award Selection Committee, American Heart Association
1992 - 1994 President Elect, AHA-Iowa Affiliate, American Heart Association
1992 - 1994 Chairman, Program Committee, American Heart Association - Iowa Affiliate
1993 - 1996 Member, Government Liaison Committee, American College of Chest Physicians
1993 Moderator, Cardiovascular Conference "Diabetes and Heart Disease", AHA National Scientific Sessions, November 7, 1993
1993 External Reviewer, SUNY-Buffalo Internal Medicine Promotions Committee
1994 Abstract Reviewer, AHA National Scientific Meeting, American Heart Association
1994 - 1996 President, AHA - Iowa Affiliate, American Heart Association
1994 External Reviewer, Lady Davis Fellowship Award, Ministry of Health, Israel
1995 - 1998 State Health Care Liaison for Iowa, American College of Chest Physicians
1995 - 1998 Treasurer, Iowa Physiological Society
1995 DelegatE, National Delegate Assembly, American Heart Association
1996 Member, Study Section: Biomedical & Behavioral Research Facilities, National Institutes of Health
1996 - 1998 Member, Public Affairs Committee, American Physiological Society
1996 Organizer, AHA Scientific Sessions Cardiovascular Seminars, “New Advances in Coronary Microvascular Control - Focus on the Human Coronary Circulation”, American Heart Association
1996 - 1999 Member, Midwest AHA Affiliate Grant Study Section, American Heart Association
1996 - 1999 Member, National AHA Clinical and CV Physiology Section, American Heart Association
1996 - 2000 Delegate, National Delegate Assembly for Council on Circulation, American Heart Association
1997 Team Leader, Intercouncil Categories for AHA 70th Scientific Session Abstract Grading and Assignments, American Heart Association
1997 - 1998 Chair, Iowa Physiological Society Networking Committee
1997 - 2000 Member, Continuing Education Committee, American College of Chest Physicians
1997 - 1999 Chair, American Heart Association Midwest Peer Review Consortium (study section on Integrative Pathophysiology, Anesthesia, Radiology, Clinical Cardiology and Development), American Heart Association
1997 Member, ACCP Task Force for Defining Guidelines for Treatment of Hypertension in the Pulmonary Patient, American College of Chest Physicians
1997 American Heart Association, AHA Scientific Sessions: Program Committee member for Circulation and ATVB Councils
1997 Member, Mentored Clinical Scientist Development Award Session Review Panel, National Institutes of Health
1997 - 1998 Chair, Government Relations Committee, American College of Cardiology, Iowa Chapter
1998 - 1999 Special Member, Cardiovascular and Renal Study Section, National Institutes of Health
1998 - 2001 Member, National American Heart Association Peer-Review Group, Cell Physiology section, American Heart Association
1998 - 2000 Member, Council on Circulation – Program Committee, American Heart Association
1998 APS representative to FASEB consensus conference on NIH funding, American Physiological Society
1999 - 2007 Chair, Industry Liaison Committee, American Physiological Society - Cardiovascular Section
1999 - Present Member, Executive Committee, American Physiological Society - Cardiovascular Section
2000 - 2009 Member, American College of Chest Physicians Evidence Based Writing Group: Pulmonary Hypertension, American College of Chest Physicians
2000 - 2009 Member, Health Science Policy Committee, American College of Chest Physicians
2000 Member, NHLBI Program Project Grant in Sickle Cell Disease Review Panel, National Institutes of Health
2000 - 2003 Member, NHLBI Cardiovascular and Renal Study Section, National Institutes of Health
2000 Abstract Reviewer, International Society of Hypertension 18th Scientific Sessions
2000 Special Member, NHLBI Cardiovascular and Renal Study Section, National Institutes of Health
2001 - 2004 Co-Chair, Programming Committee for Scientific Sessions, Council on Basic Cardiovascular Sciences, American Heart Association
2001 Symposium on “Potassium Channels that Regulate Vascular Tone: Which are the Major Players?”, FASEB,, American Physiological Society
2001 - 2004 Invited Chair, Oral abstract presentation session, Annual Scientific Sessions, American Heart Association
2002 Invited Member, NIH Workshop on Particulate Matter and Cardiovascular Disease, National Institutes of Health
2002 Member, NIH NHLBI Special Emphasis Panel for review of RFA on “Role of Infectious Agents in Vascular Disease”, National Institutes of Health
2002 Organizing Member, American College of Chest Physicians Evidence Based Writing Group: Pulmonary Hypertension, American College of Chest Physicians
2002 - Present Abstract Reviewer, American Heart Association
04/2003 Member, NHLBI Special Emphasis Panel, National Institutes of Health
06/2003 Member, NHLBI Special Emphasis Panel, National Institutes of Health
2003 - 2005 Vice-Chair, Health & Sciences Policy Committee, American College of Chest Physicians
2003 Chair, Symposium at CHEST meeting “Toys and the Heart”, American College of Chest Physicians
2003 Member, ACCP Antithrombotic Evidence Based Guideline Committee, American College of Chest Physicians
2003 ACCP Liaison, National Heart Attack Alert Program (NHAAP), American College of Chest Physicians
2003 Member, Donald W. Reynolds Foundation Cardiovascular Clinical Research Center Peer Review Committee, American Heart Association
2003 Presenter, Annual CHEST conference: “Atrial Fibrillation Evidence Based Guidelines: Pharmacological Therapy”, American College of Chest Physicians
2003 Abstract Reviewer, American College of Chest Physicians Annual Scientific Meeting (CHEST), American College of Chest Physicians
2004 - 2006 Member, Public Affairs Committee, American Physiological Society
2004 - 2011 HSP Liaison, Member of the Executive Committee, Antithrombotics Guideline Panel, American College of Chest Physicians
2004 - Present Abstract Reviewer, American College of Cardiology
2004 - 2007 Chairman, Cardiovascular Section, American Physiological Society
2004 - 2006 Chairman, Cardiovascular Disease and Hypertension Network Steering Committee, American College of Chest Physicians
2004 - 2005 Chairman, NHLBI CICS Study Section, National Institutes of Health
2005 - 2007 Chairman, Health & Science Policy Committee, American College of Chest Physicians
2005 - 2008 Member, Scientific Programming Committee, American College of Chest Physicians
2005 - 2007 Ad hoc Member, Board of Regents, American College of Chest Physicians
2006 - 2009 Member, Scientific Publishing Committee, American Heart Association
2006 Chairman, NHLBI Special Emphasis Panel, National Institutes of Health
2006 - 2007 Vice-Chair, Basic and Cardiovascular Science Council, American Heart Association
2007 - 2009 Chair, Scientific Publications Committee, American Heart Association
2007 Member, NHLBI Conference Grant Review Panel, National Institutes of Health
2007 NHLBI SEP (Hypertension and Microcirculation), National Institutes of Health
2007 Career Development Program Reviewer, Milwaukee VA Medical Center
2007 - 2008 ad hoc Member, NHLBI MIM Study Section, National Institutes of Health
2008 - 2011 Member, Board of Regents, American College of Chest Physicians
2008 - 2010 Member, Publications Committee, American Physiological Society
2009 - 2012 Member, Scientific Sessions Program Committee, American Heart Association
2009 - 2016 APS Representative, ASEB Publications and Communications Committee, American Physiological Society
2009 - 2011 Vice Chair, Ad Hoc International Education Committee, American College of Chest Physicians
2010 - 2011 President, American College of Chest Physicians
2011 - 2012 Chair, Global Education and Development Committee, American College of Chest Physicians
2012 - 2016 Member, NHLBI MIM Study Section, National Institutes of Health
2012 - 2013 Vice-Chair, Nominating Committee, American College of Chest Physicians
2013 Chairman, NHLBI Special Emphasis Panel, National Institutes of Health
2013 - 2014 Chair, Nominating Committee, American College of Chest Physicians
2013 - Present Member, AAHC’s Benchmarks & Metrics Initiative Steering Committee
04/01/2014 - Present Member, Selection Committee for Editor-In-Chief of FASEB Journal, FASEB
07/2014 Member, NHLBI Special Emphasis Panel, National Institutes of Health
08/01/2014 - 02/10/2015 Member, Selection Committee for Editor-in-Chief, Circulation, American Heart Association
11/01/2014 - 01/18/2015 Member, Strategically Focused Research Center of Excellence in Prevention, Peer Review Committee, American Heart Association
2014 Panelist, NIH Workshop on “Small Blood Vessels: Big Health Problems?”
03/2015 - 11/2016 Committee Member, Scientific Committee, 12th MOVD Symposium
04/01/2015 - 03/31/2018 Councilor, APS Council, American Physiological Society
2015 Member, Search Committee for Editor in Chief of Circulation: Cardiovascular Quality and Outcomes, American Heart Association
2015 - Present Member, Search Committee for Editor in Chief of Circulation: Cardiovascular Genetics, American Heart Association
2015 - Present Member, Professional Standards Committee, American College of Chest Physicians
01/2016 Member, NHLBI Special Emphasis Pane, National Institutes of Health
2016 - Present Member, Diversity and Inclusion Task Force, American College of Chest Physicians
2016 Member, Search Committee for Editor in Chief of Circulation: Heart Failure, American Heart Association
2016 Member, Search Committee for Editor in Chief of Circulation: Arrhythmia and Electrophysiology, American Heart Association
07/2017 Member, NHLBI Special Emphasis Panel, National Institutes of Health
2017 Chair, Search Committee for Editor-in-Chief of CHEST, American College of Chest Physicians
2017 Chair, Search Committee for Editor in Chief of Circulation- Cardiovascular Interventions, American Heart Association
2017 Chair, Search Committee for Editor in Chief of Circulation-Cardiovascular Imaging, American Heart Association
2017 - Present Chair, Strategic Planning Task Force on Education, American Physiological Society
2017 - 2018 Vice-Chair, Professional Standards Committee, American College of Chest Physicians
2017 Member, Nominating Committee, American College of Chest Physicians
2018 Member, Oversight Advisory Committee (OAC) call for the Strategically Focused Research Awards (SFRA), American Heart Association
Member, Compensation Committee, American College of Chest Physicians
Member, Research Committee (Iowa Affiliate), American Heart Association

INTERNATIONAL ELECTED/APPOINTED LEADERSHIP AND COMMITTEE POSITIONS:
1998 Grant Reviewer, National Heart Foundation of New Zealand
2017 Member, Scientific Advisory Board, Rappaport Institute, Haifa Israel

RESEARCH GRANTS/AWARDS/CONTRACTS/PROJECTS:
Active
Peer Review
Title:
TRP channels in regulation of vascular tone
Source:
NIH/NHLBI (R01 HL096647-02)
Role:
Zhang)
Dates:
02/04/11 - 01/31/16
Direct Funds:
$383,075
 
Title:
PON1 regulation of blood pressure via EDHF
Source:
Binational Science Foundation (US/Israel)
Role:
Foreign Principal Investigator (local PI: Szuchman-Sapir)
Dates:
09/01/2006 - 08/31/2018
 
Title:
Mechanisms of exertional hypertension and vascular dysfunction
Source:
NIH/NHLBI (1K23 HL085614-06)
Role:
Phillips)
Dates:
07/01/2007 - 06/30/2012
Direct Funds:
$134,720
 
Title:
PKG1-alpha activation in H202-induced flow mediated dilation of human coronary arterioles
Source:
AHA Post-Doctoral Fellowship Award - Midwest Affiliate
Role:
Supervisor of Reina Watanabe
Dates:
01/01/2011 - 12/31/2012
Direct Funds:
$90,772
 
Title:
Clinical and Translational Science Award (CTSA)
Source:
NCATS (UL1TR000055)
Role:
Program Faculty for Clinical Scholars Program (PI: Shaker)
Dates:
07/01/2015 - 06/30/2020
 
Title:
Effect of PGC-1alpha on dilation in the human microcirculation
Source:
AHA Pre-Doctoral Fellowship Award – Midwest Affiliate
Role:
Supervisor of Andrew Kadlec, MSTP student
Dates:
07/01/2016 - 06/30/2018
 
Title:
Novel Regulatory Mechanisms in the Human Microcirculation
Source:
NIH/NHLBI (R01 HL135901-01)
Role:
Principal Investigator
Dates:
12/11/2016 - 12/10/2020
 
Title:
The effects of lysophosphatidic acid on the mechanism of flow-induced dilation in human microcirculation
Source:
AHA Pre-Doctoral Fellowship Award – Midwest Affiliate
Role:
Supervisor of Dawid Chabowski, graduate student
Dates:
01/01/2017 - 12/31/2018
 
Title:
TRP channels in regulation of vascular tone
Source:
NIH/NHLBI (R01 HL096647-06)
Role:
Co-Investigator (PI: Zhang)
Dates:
02/04/2017 - 01/31/2021
 
Title:
Pivotal Role of Mitochondrial Telomerase in Regulation of Vascular Tone and Redox Homeostasis
Source:
NIH/NHLBI (RO1 HL133029-01A1)
Role:
Co-Investigator (PI: Beyer)
Dates:
03/01/2017 - 02/28/2022
 
Title:
Training in Signature Transdisciplinary Cardiovascular Sciences
Source:
NIH/1T32HL134643-01
Role:
Principal Investigator (Multiple PI with Ivor Benjamin)
Dates:
05/01/2017 - 04/30/2022
 
Prior
Peer Review
Source:
American Heart Association Grant-in-Aid
Role:
Associate Investigator (Iowa Heart)
Dates:
07/1982 - 07/1983
 
Source:
IRF - Fellowship (University of Iowa)
Dates:
1983 - Present
Direct Funds:
$15,000
 
Source:
NRSA
Dates:
1984 - 1985
Direct Funds:
$35,000
 
Source:
Clinical Investigator Award
Dates:
1986 - 1991
Direct Funds:
$320,000
 
Title:
AHA Iowa Affiliate Grant-in-Aid
Dates:
1987 - 1989
Direct Funds:
$30,000
 
Source:
Small Instruments Grant
Dates:
1987 - Present
Direct Funds:
$8,120
 
Title:
Neural Control of the Coronary Circulation in Diabetes
Source:
VA Merit Review
Role:
Principal Investigator
Dates:
1988 - 1991
Direct Funds:
$160,000
 
Source:
AHA Iowa Affiliate Grant-in-Aid
Dates:
1989 - 1990
Direct Funds:
$16,500
 
Source:
NIH SCOR
Role:
Co-Investigator; assumed PI role 12/90 upon death of former PI, M.J. Brody
Dates:
1990 - 1994
Direct Funds:
$600,000
 
Title:
Mechanisms of Cardiac Pain
Source:
NIH SCOR
Role:
Gebhart)
Dates:
1990 - 1994
Direct Funds:
$500,000
 
Source:
AHA Grant-in-Aid
Role:
Principal Investigator
Dates:
1990 - 1993
Direct Funds:
$105,000
 
Title:
Educational Grants: Cardiology Grand Rounds
Dates:
1990 - 2002
Direct Funds:
$260,000
 
Title:
Grants for Fellowship Training
Dates:
1991 - 2001
Direct Funds:
$41,300
 
Source:
AHA Iowa Affiliate Fellowship Grant (A. Goodson)
Dates:
1991 - 1992
Direct Funds:
$13,200
 
Title:
Mechanisms of Coronary Vasoregulation in Diabetes Mellitus
Source:
VA Merit Review
Role:
Principal Investigator
Dates:
1992 - 1997
Direct Funds:
$600,000
 
Source:
AHA Iowa Affiliate Fellowship (T. Abe)
Role:
Principal Investigator
Dates:
1993 - 1995
Direct Funds:
$40,000
 
Source:
AHA Established Investigator Award
Dates:
1994 - 1999
Direct Funds:
$265,000
 
Title:
Mechanisms of Coronary Blood Flow Regulation in Diabetes
Source:
R01 HL51308-01A1
Role:
Kevin Dellsperger)
Dates:
1994 - 1998
Direct Funds:
$731,120
 
Title:
AHA Iowa Affiliate Fellowship (H. Mirua)
Dates:
1995 - 1997
Direct Funds:
$40,000
 
Title:
Myogenic Control of the Human Coronary Microcirculation
Source:
NIH R01
Role:
Principal Investigator
Dates:
1996 - 1999
Direct Funds:
$475,000
 
Source:
Astra-Merck Unrestricted Educational Grant For Development of ECG Computerized Education
Role:
Co-Investigator
Dates:
1996 - 1997
Direct Funds:
$23,000
 
Source:
AHA National Grant-in-Aid
Role:
Principal Investigator
Dates:
01/01/1997 - 12/31/1999
Direct Funds:
$150,000
 
Title:
Mechanism of Altered Coronary Microvascular Reactivity in Humans with Diabetes
Source:
VA-JDF Diabetes Research Center
Role:
Principal Investigator (Project 2)
Dates:
01/01/1997 - 12/31/2001
Direct Funds:
$260,000
 
Source:
AHA-W Affiliate Fellowship
Role:
Supervisor for Ken Terata
Dates:
07/01/1998 - 06/30/2000
Direct Funds:
$40,000
 
Title:
Reduced NO-mediated Vasodilation in Human Coronary Arterioles
Source:
NIH R01
Role:
Principal Investigator
Dates:
1998 - 2002
Direct Funds:
$923,000
 
Title:
Mechanism of Flow-Mediated Vasodilation in the Human Coronary Circulation
Source:
VA Merit Review
Role:
Principal Investigator
Dates:
1998 - 2003
Direct Funds:
$300,000
 
Source:
AHA-National Scientist Development Grant
Role:
Supervisor of Yanping Liu, MD PhD
Dates:
01/01/2000 - 12/31/2004
Direct Funds:
$240,000
 
Source:
AHA-W Affiliate Fellowship
Role:
Supervisor for Atsushi Sato
Dates:
07/01/2000 - 06/30/2003
Direct Funds:
$50,000
 
Title:
Ischemic Heart Disease in African Americans
Source:
NIH SCOR
Role:
Principal Investigator; Project Leader Project #2
Dates:
2000 - 2005
Direct Funds:
$6,000,000 ($1,200,000 - project 2)
 
Title:
Oxidant Stress and Human Coronary Microvascular Function
Source:
NIH R01 (relinquished for SCOR grant described below)
Dates:
2000 - 2004
Direct Funds:
$1,120,000
 
Title:
Vascular Signaling by Free Radicals PI
Source:
NIH PPG
Role:
Harder)
Dates:
04/01/2002 - 03/31/2007
 
Source:
AHA-W Affiliate Fellowship
Role:
Supervisor for Hong-Wei Li
Dates:
07/01/2002 - 06/30/2003
Direct Funds:
$50,000
 
Source:
AHA Affiliate Grant-in-Aid
Role:
Supervisor of Hiroto Miura, MD, PhD, PI
Dates:
01/01/2003 - 12/31/2005
Direct Funds:
$150,000
 
Title:
Effect of Hyperglycemia on Potassium Channel function
Source:
NIH R01
Role:
Principal Investigator
Dates:
04/01/2003 - 03/31/2007
Direct Funds:
$1,000,000
 
Title:
Redox Mechanisms in the Vascular Dysfunction of Inflammatory Bowel Disease
Source:
AHA Fellowship Award - Wisconsin Affiliate
Role:
PI
Dates:
07/01/2003 - 06/30/2005
Direct Funds:
$60,000
 
Title:
Role of Epoxyeicosotrienoic Acid as EDHF in Human Coronary Arterioles
Source:
VA Merit Review
Role:
Principal Investigator
Dates:
01/01/2004 - 01/15/2009
Direct Funds:
$650,000
 
Source:
AHA Fellowship Award - Wisconsin Affiliate
Role:
Supervisor of Brandon Larsen, MSTP student
Dates:
07/01/2005 - 06/30/2007
Direct Funds:
$65,000
 
Title:
Clinical Research Curriculum Award
Source:
NIH K30 (HL04112-01)
Role:
Dunn)
Dates:
01/01/2006 - 12/31/2011
Direct Funds:
$1,750,000
 
Title:
Flow-Mediated Dilation of Human Coronary Arterioles
Source:
NIH/NHLBI (R01 HL080704)
Role:
Principal Investigator
Dates:
01/01/2006 - 12/31/2011
Direct Funds:
$1,250,000
 
Source:
Soy Health Research Program for the United Soybean Board "Seed grant"
Role:
Phillips)
Dates:
12/01/2006 - 11/30/2007
Direct Funds:
$10,000
 
Title:
Role of IKCa Channels in Vascular Remodeling
Source:
NIH/NHLBI (R01 HL080173-01)
Role:
Miura)
Dates:
07/01/2007 - 06/30/2012
Direct Funds:
$1,125,000
 
Title:
Role of Hydrogen Peroxide in the Mechanism of Flow-Induced Dilation of the Human Coronary Microcirculation
Source:
NIH/NHLBI (R01 HL094971-01)
Role:
Principal Investigator
PI:
Self
Dates:
01/01/2009 - 12/31/2012
Direct Funds:
$376,200
 
Source:
NIH/NHLIB (R21 HL092344-02)
Role:
Migrino)
Dates:
07/01/2009 - 03/31/2011
Direct Funds:
$143,000
 
Title:
Effects of low carbohydrate and low fat diets on endothelium function in human OB
Source:
NIH/NHLBI (R01 HL095701-02)
Role:
Phillips)
Dates:
08/01/2010 - 07/31/2015
Direct Funds:
$907,398
 
Title:
Mechanism of Flow-Induced Dilation in the Human Microcirculation
Source:
NIH/NHLBI (R01 HL3612-01A1)
Role:
Principal Investigator
Dates:
02/15/2013 - 01/31/2017
Direct Funds:
$298,258
 

INVITED LECTURES/WORKSHOPS/PRESENTATIONS:
Local
Visiting Professor and Physiology Seminar Speaker, Department of Physiology, Medical College of Wisconsin, 01/1998
Dudley Johnson Symposium, Medical College of Wisconsin, 11/2000
Novel mechanism of flow-induced vasodilation in the human coronary microcirculation, University of Wisconsin Cardiovascular Center, Madison, WI, 03/2006
 
Regional
Cardiology Division, Henry Ford Hospital, Detroit, MI, 11/1986
Michael J. Brody Symposium, Iowa City, IA, 12/1991
Medical Research and the AHA, Iowa City Optimist Club, Iowa City, IA, 12/1992
Silent Myocardial Ischemia, 1993 Family Practice Refresher Course, Iowa City, IA, 03/1993
Central Control of the Coronary Circulation, Melvin C. Marcus Symposium, Iowa City, IA, 10/1993
Neural Cardiac Stunning – Basic Science and Clinical Implications, Anesthesiology Grand Rounds, University of Chicago, Chicago, IL, 08/2000
University of Iowa Cardiovascular Distinguished Alumni Award Lecture, Iowa City, IA, 06/2003
Flow-Induced Vasodilation : A Window Into Vascular Health and Disease, Cardiology Grand Rounds, Northwestern University, 03/03/2014
Human Coronary Microcirculation: Small Vessels - Big Impact, Dedication of University of Iowa Francois M Abboud Cardiovascular Center, Iowa City, IA, 10/2014
Cardiac Contractility Modulation for Heart Failure: Mechanism of Action, Ohio State University Electrophysiology Seminar, Columbus, Ohio, 01/29/2015
 
National
Cardiology Division, SUNY, New York, NY, 02/1987
Central Neural Control of Coronary Circulation, Symposium on Neural Control of the Circulation, American College of Cardiology, 03/1990
AHA Winter Conference, Snow Bird, Utah, 01/1991
Department of Physiology, Texas A&M University, 10/1991
Wyeth-Ayerst Research Awards Symposium, Princeton, NJ, 02/1992
National AHA Symposium Public Affairs Issues and the AHA, 08/1992
Visiting Scientist: SUNY Buffalo Cardiology Division, Center for Cardiopulmonary Biology Seminar Mechanisms of Neural Cardiac Stunning, Buffalo, New York, 02/1996
Physiological Control of Human Coronary Arterioles, AHA Scientific Sessions, 11/1996
University of Alabama at Birmingham's 11th Annual Vascular Biology and Hypertension Symposium, 10/2000
Physiology Department Seminar, New York Medical College, Valhalla, NY, 12/2000
Microvascular Function: EDHF vs. NO which is in Control?, Symposium Chair and Presenter: AHA Scientific Sessions, 2000
• Medical College of Georgia, Department of Physiology, 01/2001 - 01/2004
Cardiology Grand Rounds, University of Louisville, Louisville, KY, 02/2001
Duke University Cardiology Grand Rounds, 02/2003
University of North Carolina Cardiology Grand Rounds, 03/2003
UAB Vascular Biology and Hypertension Seminar, 03/2003
25th Annual Meeting of the International Society for Heart Research (ISHR), Mystic, CT, 06/2003
Boron Lecturer, UCLA Cardiology Division, 10/2003
Louisiana State University, Department of Physiology, Shreveport, LA, 02/2004
Cardio-Kidney Investigators’ Meeting, Amelia Island, FL, 05/2004
Cardio-Kidney Investigators Meeting, Amelia Island, FL, 05/2005
EDHF and Nitric Oxide interactions in the circulation, Cardiovascular Seminar: AHA Scientific Meeting, Dallas TX, 2005
Novel mechanisms regulating the Coronary Circulation, Cardiovascular Seminar: AHA Scientific Meeting, Dallas TX, 2005
Mechanisms of flow-induced dilation in the human coronary vasculature, AHA BCVS Summer Conference, Keystone, CO, 07/2006
Redox Signaling: From Physiology to Pathology, AHA Scientific Sessions: Redox Signaling in Cardiovascular DIsease, Chicago, IL, 11/17/2014
Endothelium-Dependent Dilation in the Human Microcirculation: Blurring the Lines Between Health and Disease, Seminar, Department of Pharmacology, Tulane University, New Orleans, LA, 04/23/2015
• Flow-Mediated Vasodilation: a Window into Vascular Health and Disease, Internal Medicine Grand Rounds, State University of New York, Buffalo, NY, 05/21/2015
Human Vascular Function in Health and Disease, Invited lecture, Department of Physiology, University of Louisville, KY, 02/23/2016
Endothelium-Dependent Dilation in the Human Microcirculation in health and disease, Invited speaker, Department of Integrative Medical Sciences, NEOMED, Rootstown, OH, 03/01/2016
Flow-Induced Dilation in the Human Microcirculation, Invited speaker, LSU Health Sciences Center, Shreveport, LA, 06/06/2016
Human Microvascular Function: Mechanisms in health and disease, 19th International Vascular Biology Meeting, Boston, MA, 10/31/2016
Endothelial Function in the Human Microcirculation: a Unique Window into Cardiovascular Health and Disease, Mechanisms of Vasodilation 12th International Symposium, Boston, MA, 11/08/2016
Differentiating Cardiovascular from Pulmonary causes of Dyspnea, Lennox Hill Hospital Grand Rounds (Pulmonary division), New York City, NY, 04/2017
Obstructive Sleep Apnea and Cardiovascular Diseases, Lennox Hill Hospital Pulmonary Division, New York City, NY, 04/2017
Determinants of Vasomotor Control in Humans Change During Aging and Disease, Microcirculatory Society President’s Symposium, 04/2017
Human Microvascular Function and Health, Dept. Kinesiology, Penn State University, State College Pennsylvania, 03/2018
 
International
Central Regulation and Integration of Coronary Vasomotion, Henry Goldberg Symposium (IV), Haifa, Israel, 05/1987
Use of Echocardiography in Evaluating Patients for Cardiac Source of Embolus, International Conference on Cardiac Instrumentation, Nice, France, 02/1992
Effect of Brief Ischemia on Neural Coronary Control, Bioengineering Seminar, Technion Institute of Technology, Haifa, Israel, 09/1993
Diagnosis and Treatment of Silent Myocardial Ischemia, Akita University Lecture Series, Akita, Japan, 02/1994
Central Neural Control of the Coronary Circulation, 1st Department of Physiology, Kurume Medical Center, Kurume, Japan, 02/1994
Central Neural Control of the Coronary Circulation, University of Occupational & Environmental Health, Kitakyushu, Japan, 03/1994
Neural Control of Coronary Blood Flow, Tel Hashomer Department of Cardiovascular Diseases, Sheba Medical Center, Israel, 08/1994
Control of Tone in Human Microvessels, Coronary Physiology and Cardiac Metabolism Workshop, International Union of Physiological Sciences (IUPS) XXXIII Congress, St. Petersburg, Russia, 06/1997
Keynote Speaker, 3rd Tohoku Cardiac and Renal Conference, Sendai, Japan, 06/1998
Ion Channels and Cardiovascular Regulation, Sapporo International Symposium, Hokkaido University Faculty House, Sapporo, Japan, 06/1998
Integrated Control of Pressure and Blood Flow in Coronary Microcirculation, International Workshop Co-Chair, Pisa, Italy, 06/2000
5th Scientific Meeting for Pharmacotherapy of Cardiovascular Diseases, Tokyo, Japan, 06/2001
Symposium on Cardiovascular Function, Akita, Japan, 10/2001
Symposium on Cardiovascular Function, Beijing Friendship Hospital, Beijing, China, 05/2002
Keynote Speaker, 2nd International Symposium on EDHF, Tokyo, Japan, 01/2003
11th William Ganz Symposium Program – Vascular Biology Update, Akita, Japan, 04/2003
British Pharmacology Society Annual Meeting, Bath, England, 07/2004
Understanding Blood Vessels, Symposium Chair: XVIII World Congress, International Society for Heart Research, Brisbane, Australia, 08/2004
How are Evidence-Based Guidelines Developed? The ACCP Health and Science Policy Committee Step-by-Step Process, Plenary Session, CHEST, Montreal, Quebec, Canada, 2005
EDHF in the coronary circulation, Medical Physics Meeting, Amsterdam, 02/2007
Endothelium-Dependent Dilation in the Human Microcirculation: A Window Into Vascular Health and Disease, Kiryat Shmona, Israel, 06/11/2014
CCM mechanism of Action – from Cellular to Autonomic Nervous Response, DGK Conference, Mannheim, Germany, 04/09/2015
• Cardiac Contractility Modulation – Mechanism of Action and Clinical Experience, Clinical Advisory Committee Presentation, Wisla, Poland, 10/2017
 

COMMITTEE SERVICE:
Medical College
1980 - 1984 Member, Resident Selection Committee
1988 - 1998 Member, Fellowship Selection Committee, Cardiology Division
1989 - 1998 Chairman, Cardiology Subcommittee on Fellowship Training Assessment and Continuing Education
1992 - 1997 Member, Clinical Research Center Protocol Review Committee
1992 - 1993 Member, Promotions Committee, Medicine, Internal Medicine
1992 - 1997 Director of Educational Programming, Medicine, Cardiology
1995 - 1998 Associate Director, Cardiology Fellowship Program
1995 - 1998 Member, Resource Facilities and Space Committee of Internal Medicine
1995 - 1998 Chair, Cardiology Fellowship Research Training Committee
1995 - 1998 Member, Faculty Advisory Committee
1995 - 1998 Organizer, Cardiology Division Retreat
1995 - 1998 Chairman, Cardiology Fellowship Research Training Committee
1996 - 2000 Investigator, DERC
1997 - 1998 Member, Cardiology Clinical Operations Group
1998 - Present Associate Director, Cardiovascular Center, Medical College of Wisconsin
1998 - Present Cardiovascular Center Executive Committee
2000 - Present Member, Strategic Planning Committee, Medical College of Wisconsin
2001 - Present Chair, Nephrology Chief Search Committee, Medicine, Medical College of Wisconsin
2003 - Present Chair, Endocrinology Chief Search Committee, Medicine, Medical College of Wisconsin
2003 - 2005 Co-director, Translational Research Initiative, Medical College of Wisconsin
2012 - 2013 Chair, Chief of Cardiology/Director of CV Center Search Committee
2013 - 2015 Member, Center for Cardiovascular and Respiratory Sciences, External Advisory Committee, West Virginia University
2016 - 2018 Member, Diversity and Inclusion Advisory Committee, Medical College of Wisconsin
2018 - Present Member, Chair of Physiology Search Committee, Medical College of Wisconsin
 
Hospital
1983 - 1984 Member, Hospital Information System Committee
1988 - 1992 Member, VA Animal Care Committee
1989 - 1992 Chairman, VA Animal Care Committee
1993 - 1996 Member, VA Research and Development Committee
1997 - 1998 Chief of Cardiology, VA Medical Center
 

MEDICAL COLLEGE TEACHING ACTIVITIES:
Medical Student Education
1986 - 1998 Cardiovascular Seminar, Co-director, Weeks per Year:50; Hours per Week:2
1999 MCW Internal Medicine Grand Rounds
 
Resident and Fellow Education
1986 Coronary Physiology Journal Club, Weeks per Year:50; Hours per Week:1.5
1988 Director, Cardiology Grand Rounds Weeks per Year:15; Hours per Week:2
1998 MCW Cardiology Grand Rounds
1999 - Present MCW Cardiology Fellow Lecture on Coronary Circulation
1999 - Present MCW Cardiology Fellow Lecture on Endothelial Pathobiology
 

MCW STUDENTS, FACULTY, RESIDENTS AND CLINICAL/RESEARCH FELLOWS MENTORED:
Graduate Students
Geetanjali Dang, Medical College of Wisconsin, 06/2015 - Present
 
Postdoctoral Students
Peter Pardubsky, Medical College of Wisconsin, 1986 - 1990 Predoctoral Fellow
Brandon Larsen, Medical College of Wisconsin, 2004 - 2010 MSTP (MD/PhD) Program
Andrew Kadlec, Medical College of Wisconsin, 2015 - 2018 MSTP (MD/PhD) Program Thesis Supervisor
 

EXTRAMURAL STUDENTS, FACULTY, RESIDENTS, AND CLINICAL/RESEARCH FELLOWS MENTORED:
Undergraduate Students
Peter Pardubsky, 1987 - 1990 Undergraduate Scholarship Assistance Program
Michael Pettersen, 1989 - 1990 Undergraduate Scholarship Assistance Program
Melanie Danehy, 1989 - 1991 Undergraduate Scholarship Assistance Program
Michael Breu, 1994 - 1996 Undergraduate Scholarship Assistance Program
Rohit Sahai, 1995 - 1997 Undergraduate Scholarship Assistance Program
 
Medical Students
Francis Miller, 1988 - 1989 AHA Medical Student Fellowship
Tim LaMaster, 1989 Medical Student Research Summer Program
Ian Law, 1990 Medical Student Research Summer Program
Dan McDermott, 1990 - 1991 AHA Medical Student Fellowship
Yasemin Murad, 1990 Medical Student Research Summer Program
Rafael Lupercio, 1990 Medical Student Research Summer Program
Peter Pardubsky, 1990 Medical Student Research Summer Program
Angie Cave, 1991 - 1992 AHA Medical Student Fellowship
Jennifer Bocker, 1992 - 1995 University of Iowa Honors Program
Angie Goodson, 1992 Medical Student Research Summer Program
Corey Ingram, 1993 University of Iowa Honors Program
Eduardo Rodriguez, 1994 - 1995 AHA Medical Student Fellowship
Neelay Kothari, 1995 - 1996 University of Iowa Honors Program
Jennifer Bocker, 1995 - 1996 AHA Medical Student Fellowship
Sheree Murphy, 1996 - 1997 AHA Medical Student Fellowship
Joseph Williams, 1996 Summer Research Experience Program
Amy Sung, 1996 Summer Research Experience Program
Stacey George, 1997 Medical Student Research Summer Program
Brian Rupert, 1997 AHA Medical Student Fellowship
Eric Scott, 1997 Medical Student Research Summer Program
Sarvenaz Jabbari, 1997 Summer Research Experience Program
Megan Staten, 1999 Medical Student Research Summer Program
Susan Pitt, 2001 - 2002 Medical Student Research Summer Program
Jackie Kulinski, 2005 - 2008 Medical College of Wisconsin Honors Program
Pui Lai, 2008 Medical Student Research Summer Program
Hans Huang, 2010 - 2012 Medical College of Wisconsin Honors Program
Hans Huang, 2010 Medical Student Research Summer Program, Winner of Summer Research Poster Presentation Award
Cullen Buchanan, 2015 - 2018 Medical College of Wisconsin Honors Program
 
Graduate Students
Peter Pardubsky, 1986 - 1990
Angie Goodson, 1987 - 1991
Nauman Siddiqi, MD, 2002 - 2003
Francisco Soto, MD, 2003
Tyriina O’Neil, 2009
Jason Maas, 2009
Michael Richman, 2013 - 2016, Graduated with Honors in research.
Dawid Chabowski, 2014 - Present
Cullen Buchanan, 2015 - 2018, Graduated with Honors in research.
MS
Jason Clyne, MS, Marquette University, 2001 - 2003
Committees
Paul Rogers, 2005 - 2007
Yuttana Chawengsub, 2006 - 2008
Lauren Olson, 2007 - 2010
Matthew Durand, 2007 - 2010
Jason E. Maas, 2009 - 2011
 
Postdoctoral Students
Robert Paul, MD, 1988 - 1990 Postdoctoral
Francis Miller, MD, 1988 - 1989 Postdoctoral
Stephan DeBoel, MD, 1988 - 1991 Postdoctoral
James Quillen, MD, 1990 - 1991 Postdoctoral
Francis Miller, MD, 1992 - 1996 Postdoctoral
Robyn Foy, PhD, 1993 - 1994 Postdoctoral
Toyohiko Abe, MD, PhD, 1993 - 1995 Postdoctoral
Kalyana Sundarum, MD, 1993 - 1997 Postdoctoral
Hiroto Miura, MD, PhD, 1995 - 1998 Postdoctoral
Ken Terata, MD, PhD, 1997 - 2000 Postdoctoral
Atsushi Sato, MD, PhD, 2000 - 2003 Postdoctoral
Ossama Abu-Hatoum, MD, 2001 - 2004 Postdoctoral
Cevher Ozcan, MD, 2003 - 2004 Postdoctoral Medicine Resident
Shane Phillips, PhD, 2004 - 2005 Postdoctoral
Anna Knight, MD, 2004 - 2006 Postdoctoral
Natalya Zinkevich, 2008 - 2013 Postdoctoral
Reina Watanabe, PhD, 2009 - 2012 Postdoctoral
Matt Durand, PhD, 2010 - 2015 Postdoctoral
Julie Freed MD, PhD, 2011 - 2016 Postdoctoral
Chuan Wen, PhD, 2013 - 2014 Postdoctoral
Ji Li, PhD, 2014 - 2015 Postdoctoral
Geetanjali Dang, MD, 2015 - 2016 Postdoctoral
 
Clinical/Research Fellows
Shane Phillips, PhD, 2004 - 2006 Clinical Research Scholars Program, Mentor
Michael Widlansky MD, 2006 - 2008 Clinical Research Scholars Program, Mentor
Matt Durand, PhD, 2012 - 2014 Clinical Research Scholars Program, Mentor
Jackie Kulinski MD, 2015 - Present Clinical Research Scholars Program, Mentor
 

CLINICAL TEACHING (IN WARD, CLINIC, OR OPERATING ROOM):
1985 - 1996 Introduction to Clinical Medicine (M2 Physical Exam Teaching) Year: 1985, 1987, 1990, 1991, 1993, 1996 Weeks per Year: 6; Hours per Week: 8
1986 - Present Where Occurred: VA Cardiology Clinic Weeks per Year: 48; Hours per Week: 5
1986 - 2010 Where Occurred: General Medicine Ward Weeks per Year: 4; Hours per Week: 30

CLINICAL ACTIVITIES:
Cardiology Outpatient Clinics – Froedtert Memorial Lutheran Hospital
Consultant Service – FMLH
Coronary Care Unit – VA Medical Center, Milwaukee
Cardiology Inpatient Wards – VA Medical Center, Milwaukee
Cardiology Outpatient Clinics – VA Medical Center, Milwaukee
Cardiology Consult Service – VA Medical Center, Milwaukee
Electrocardiography Station – FMLH

EXTRAMURAL TEACHING:
1989 - 1991 Course Title: Introduction to Clinical Medicine (Lecture on Heart Sounds and Cardiac Auscultation to M2s) (4 Hour Lecture)
1993 - 1999 Course Title: Introduction to Clinical Medicine (Lecture on Heart Sounds and Cardiac Auscultation to M2s) (4 Hour Lecture)

OTHER POSITIONS:
2017 - Present Academic Consultant, EPD Medical

OTHER POSITIONS :
2014 - Present Academic Medical Advisor, Impulse Dynamics

OTHER STUDENTS SUPERVISED :
1988 - 2018 Angie Cave (1988 – 90) Corrine Barber (1988 – 90) Michelle Weinrieich (1991) Mark Richardson (1991 – 92) Jim Cook (1992 – 93) Eric Scott (1993 – 97) Kristen Beasley (1996 – 97) Sean Johnson (1996 – 98) Lisa Evoy (1996 – 98) Jill Prader (1996 – 98) Sam Kang (1997 – 98) Luann Eberhart (1999 – 2000) John Bosnjak (2000 – 04) Elana Rudman (2003) Tamara McArthur (Undergraduate Minority Research Program 2003) Peter Shumann (Undergraduate trainee 2014) Jakayla Dills (Undergraduate Minority Research Program, 2015) Nabeel Quryshi (undergraduate trainee, 2014-2018)(Siemens Westinghouse National Science Competition finalist ; 1st place in Medicine/Behavioral Sciences Competitiion Badger State Science and Engineering Fair ; Yale Science and Engineering Award ; International science and Engineering Fair finalist ; First place 2017 Intel International Science and Engineering fair in biomedical health sciences, Best in category : 2018 Intel International Science and Engineering Fair in biomedical health sciences; Dudley R. Hershbach SIYSS award; 2018 US Presidential scholar – 160 of 3.6 million high school students receive this award each year)


BIBLIOGRAPHY
Refereed Journal Publications/Original Papers
1. Gutterman DD, Rusch NJ, Hermsmeyer K, Dole WP: Differential Reactivity to 5-Hydroxytryptamine in Canine Coronary Arteries. Blood Vessels. 23:165-172, 1986.
2. Gutterman DD, Chilian WM, Eastham CL, Inou T, White CW, Marcus ML: Failure of Pyruvate to Salvage Myocardium after Prolonged Ischemia. Am J Physiol. (Heart Circ. Physiol.) 19(1):H114-H120, 1986.
3. Bonham AC, Gutterman DD, Arthur JA, Marcus ML, Gebhart GF, Brody MJ. Electrical Stimulation in Pericortical Lateral Hypothalamus Decreases Coronary Blood Flow in Cat. Am J Physiol. 252:H474-H484, 1987.
4. Bonham AC, Gutterman DD, Arthur JM, Marcus ML, Gebhart GF, Brody MJ. Neurogenic Regulation of Coronary Blood Flow: Evidence for a Central Nervous System Pathway. Circ Res. 61(Suppl. II):II-42-II-46, 1987.
5. Gutterman DD, Bonham AC, Arthur JM, Gebhart GF, Marcus ML, Brody MJ. Characterization of a coro¬nary vasoconstrictor site in medullary reticular formation. Am J Physiol 1989 Apr;256(4 Pt 2):H1218-27.
6. Gutterman DD, Bonham AC, Gebhart GF, Marcus ML, Brody MJ. Connections between Hypothalamus and Medullary Reticular Formation Mediate Coronary Vasoconstriction. Am J Physiol. 259:H917-H924, 1990.
7. Arthur JM, Bonham AC, Gutterman DD, Gebhart GF, Marcus ML, Brody MJ. Coronary Vasoconstriction During Stimulation in the Hypothalamic Defense Region. Am J Physiol. 260:R335-R345, 1991.
8. Gutterman DD, Pardubsky PD, Clothier JL, Marcus ML, Brody MJ. Coronary Vasoconstriction in Response to Epicardial Hypothermia. Coronary Artery Disease. 2:75-86, 1991.
9. Gutterman DD, Gebhart GF, Pardubsky PD, Clothier J, Arthur SA, Marcus ML, Brody MJ. Role of Medullary Lateral Reticular Formation in Baroreflex Coronary Vasoconstriction. Brain Res. 557:202-209, 1991.
10. Miller FM, Brody MJ, Marcus ML, Gutterman DD. Activation in the region of Parabrachial Nucleus Elicits Neurogeni¬cally Mediated Coronary Vasoconstriction. Am J Physiol. 261:H1585-1596, 1991.
11. Jones LF, Gutterman DD, Brody MD. Patterns of Hemodynamic Responses Associated with Central Activation of Coronary Vasoconstriction. Am J Physiol. 262:R276-R283, 1992.
12. Gutterman DD, Morgan DA, Miller FM. Effect of Brief Myocardial Ischemia on Sympathetic Coronary Vasocon¬striction. Circ Res 71:960-969, 1992.
13. Ben-Haim SA, Becker B, Gutterman DD, Kaplinsky E, Palti Y. Prediction of Immediate Ventricular Arrhyth¬mias Following Coronary Artery Ligation. J Am Coll Cardiol. 20(5):1270-1276, 1992.
14. DeBoel SL, Gutterman DD. Coronary Vascular Response to Cerebral Ischemia Reflex. Hypertension. 21:216-221, 1993.
15. Goodson AR, LaMaster TS, Gutterman DD. Coronary Vasoconstrictor Pathway from Anterior Hypothalamus Includes Neurons in Rostroventrolateral Medulla. Am J Physiol. 265:R1311-R1317, 1993.
16. Goodson AR, Leibold JM, Gutterman DD. Inhibition of Nitric Oxide Synthesis Augments Centrally-Induced Sympathetic Coronary Vasoconstriction in Cats. Am. J. Physiol. 267:H1272-1278, 1994.
17. Pettersen MD, Abe T, Morgan DA, Gutterman DD. Role of Adenosine in Postischemic Dysfunction of Coronary Innervation. Circ Res. 76:95-101, 1995.
18. Scott I, Gutterman DD. Pheochromocytoma with Reversible Focal Cardiac Dysfunction. Am Heart J. 130(4):909-911, 1995.
19. Gutterman DD, Morgan DA. Transmural Regulation of Myocardial Perfusion by Neuropeptide Y. Basic Res. Cardiol. 90:348-355, 1995.
20. McDermott DA, Meller ST, Gebhart GF, Gutterman DD. Use of an Indwelling Catheter for Examining Cardiovascular Reponses to Pericardial Administration of Bradykinin in Rat. Cardiovascular Research. 30(1):39-46, July, 1995.
21. Gutterman DD, Goodson AR. The Role of Parabrachial Nucleus in Baroreflex Mediated Coronary Vasoconstriction. Am J Physiol. 271:H1079-H1086, 1996.
22. Abe T, Morgan DA, Gutterman DD. Role of Adenosine Receptor Subtypes in Neural Stunning of the Sympathetic Coronary Innervation. Am J Physiol. 272:H25-H34, 1997.
23. Abe T, Morgan DA, Gutterman DD. Protective Role of Nerve Growth Factor Against Postischemic Dysfunction of Sympathetic Coronary Innervation. Circulation. 95:213-220, 1997.
24. Miller FJ, Dellsperger KC, Embrey RP, Gutterman DD. Myogenic Constriction of Human Coronary Arterioles. Am J Physiol. 273: H257-H264, 1997.
25. Miura H, Morgan DA, Gutterman DD. Oxygen-Derived Free Radicals Contribute to Neural Stunning in the Canine Heart. Am J Physiol. 273:H1569-H1575, 1997.
26. Oltman C, Gutterman DD, Scott EC, Bocker JM, Dellsperger KC. Effects of glycosylated hemoglobin on vascular responses in vitro. Cardiovasc Res 1997 Apr;34(1): 179-84.
27. Gutterman DD, Pardubsky PD, Pettersen M, Marcus ML, Gebhart GF. Thoracic spinal neuron response to repeated myocardial ischemia and epicardial bradykinin. Brain Res 1998 Apr 20;790(1-2):293-303.
28. Miller FJ Jr, Dellsperger KC, Gutterman DD. Pharmacologic activation of the human coronary microcirculation in vitro: endothelium-dependent dilation and differential responses to acetylcholine. Cardiovascular Res 1998 Jun;38(3):744-50.
29. Miller FJ Jr, Gutterman DD, Rios CD, Heistad DD, Davidson BL. Superoxide production in vascular smooth muscle contributes to oxidative stress and impaired relaxation in atherosclerosis. Circ Res. 1998 Jun 29;82(12):1298-305.
30. Abe T, Morgan D, Sengupta JN, Gebhart GF, Gutterman DD. Attenuation of ischemia-induced activation of cardiac sympathetic afferents following brief myocardial ischemia in cats. J Auton Nerv Syst. 1998 Jun 30;71(1):28-36.
31. Miura H, Gutterman DD. Human coronary arteriolar dilation to arachidonic acid depends on cytochrome P-450 monooxygenase and Ca2+-activated K+ channels. Circ Res 1998 Sep 7;83(5):501-7.
32. Miura H, Liu Y, Gutterman DD. Human coronary arteriolar dilation to bradykinin depends on membrane hyperpolarization: contribution of nitric oxide and Ca2+-activated K+ channels. Circulation 1999 June 22;99(24):3132-8.
33. Terata K, Coppey LJ, Davidson EP, Dunlap JA, Gutterman DD, Yorek MA. Acetylcholine-induced arteriolar dilation is reduced in streptozotocin-induced diabetic rats with motor nerve dysfunction. Br J Pharmacol 1999 Oct;128(3):837-43. PMCID: PMC1571695
34. Oltman CL, Kane NL, Gutterman DD, Bar RS, Dellsperger KC. Mechanism of coronary vasodilation to insulin and insulin-like growth factor I is dependent on vessel size. Am J Physiol Endocrinol Metab 2000 Jul; 279(1):E176-81.
35. Ammar RF Jr, Gutterman DD, Brooks LA, Dellsperger KC. Free radicals mediate endothelial dysfunction of coronary arterioles in diabetes. Cardiovasc Res 2000 Aug 18;47(3):595-601.
36. Ammar RF Jr, Gutterman DD, Brooks LA, Dellsperger KC. Impaired dilation of coronary arterioles during increases in myocardial O2 consumption with hyperglycemia. Am J Physiol Endocrinol Metab 2000 Oct;279(4):E868-74.
37. Terata K, Miura H, Liu Y, Loberiza F, Gutterman DD. Human coronary arteriolar dilation to adrenomedullin: role of nitric oxide and K(+) channels. Am J Physiol Heart Circ Physiol 2000 Dec;279(6):H2620-6.
38. Miura H, Wachtel RE, Liu Y, Loberiza FR Jr, Saito T, Miura M, Gutterman DD. Flow-induced dilation of human coronary arterioles: important role of Ca(2+)-activated K(+)-channels. Circulation 2001 Apr 17;103(15):1992-8.
39. Nair BA, Murad YZ, Brody MJ, Gutterman DD. Ouabain-induced coronary vasoconstriction in cats is not neurally mediated. Clin Exp Pharmacol Physiol 2001 Jul;28(7):510-7.
40. Bocker JM, Miller FJ, Oltman CL, Chappell DA, Gutterman DD. Calcium-activated potassium channels mask vascular dysfunction associated with oxidized LDL exposure in rabbit aorta. Japanese Heart J 2001 May;42(3):317-26.
41. Liu YP, Terata K, Rusch NJ, Gutterman DD. High glucose impairs voltage-gated K(+) channel current in rat small coronary arteries. Circ Res 2001 Jul 20;89(2):146-52.
42. Sato A, Miura H, Liu Y, Somberg LB, Otterson MF, Demeure MJ, Schulte WJ, Eberhardt LM, Loberiza FR, Sakuma I, Gutterman DD. Effect of gender on endothelium-dependent dilation to bradykinin in human adipose microvessels. Am J Physiol Heart Circ Physiol 2002 Sep;283(3):H845-52.
43. Liu Y, Terata K, Chai Q, Li H, Kleinman LH, Gutterman DD. Peroxynitrite inhibits Ca2+-activated K+ channel activity in smooth muscle of human coronary arterioles. Circ Res 2002 Nov 29;91(11):1070-6.
44. Dart RA, Gregoire JR, Gutterman DD, Woolf SH. The association of hypertension and secondary cardiovascular disease with sleep-disordered breathing. Chest 2003 Jan;123(1):244-60.
45. Miura H, Wachtel RE, Loberiza, FR Jr, Saito T, Miura M, Nicolosi AC, Gutterman DD. Diabetes mellitus impairs vasodilation to hypoxia in human coronary arterioles: reduced activity of ATP-sensitive potassium channels. Circ Res 2003 Feb 7;92(2):151-8.
46. Miura H, Bosnjak JJ, Ning G, Saito T, Miura M, Gutterman DD. Role for hydrogen peroxide in flow-induced dilation of human coronary arterioles. Circ Res 2003 Feb 7;92(2):e31-40.
47. Hoch AZ, Dempsey RL, Carrera GF, Wilson CR, Chen EH, Barnabei VM, Sandford PR, Ryan TA, Gutterman DD. Is there an association between athletic amenorrhea and endothelial cell dysfunction? Med Sci Sports Exerc, 2003 Mar;35(3):377-83.
48. Bosnjak JJ, Terata K, Miura H, Sato A, Nicolosi AC, McDonald M, Manthei SA, Saito T, Hatoum OA, Gutterman DD. Mechanism of thrombin-induced vasodilation in human coronary arterioles. Am J Physiol Heart Circ Physiol 2003 Apr;284(4): H1080-6.
49. Ou J, Ou Z, Jones DW, Holtzhauer S, Hatoum OA, Ackerman AW, Weihrauch DW, Gutterman DD, Guice K, Oldham KT, Hillery CA, Pritchard KA Jr. L-4F, an apolipoprotein A-1 mimetic, dramatically improves vasodilation in hypercholesterolemia and sickle cell disease. Circulation 2003 May;107(18):2337-41.
50. Hatoum OA, Binion DG, Otterson MF, Gutterman DD. Acquired microvascular dysfunction in inflammatory bowel disease: loss of nitric oxide-mediated vasodilation. Gastroenterology 2003 Jul;125(1):58-69.
51. Peles S, Petersen J, Aviv R, Policker S, Abu-Hatoum O, Ben-Haim SA, Gutterman DD, Sengupta JN. Enhancement of antral contractions and vagal afferent signaling with synchronized electrical stimulation. Am J Physiol Gastrointest Liver Physiol 2003 Sep;285(3):G577-85.
52. Li H, Chai Q, Gutterman DD, Liu Y. Elevated glucose impairs cAMP-mediated dilation by reducing Kv channel activity in rat small coronary smooth muscle cells. Am J Physiol Heart Circ Physiol 2003 Sep;258(3):H1213-9.
53. Liu Y, Zhao H, Li H, Kalyanaraman B, Nicolosi AC, Gutterman DD. Mitochondrial sources of H2O2 generation play a key role in flow-mediated dilation in human coronary resistance arteries. Circ Res 2003 Sep 19;93(6):573-80.
54. Oltman CL, Clark CB, Kane NL, ZhangY, Gutterman DD, Dellsperger KC, Kerber RE. Coronary vascular dysfunction associated with direct current shock injury. Basic Res Cardiol 2003 Nov;98(6):406-15.
55. Sato A, Sakuma I, Gutterman DD. Mechanism of dilation to reactive oxygen species in human coronary arterioles. Am J Physiol Heart Circ Physiol. 2003 Dec;285(6):H2345-54.
56. McGoon M, Gutterman DD, Steen V, Barst RJ, McCrory DC, Fortin TA, Loyd JE. Screening, early detection, and diagnosis of pulmonary arterial hypertension: ACCP evidence-based clinical practice guidelines. Chest 2004 Jul;126(1 Suppl):14S-34S.
57. Stein PD, Schünemann HJ, Dalen JE, Gutterman DD. Antithrombotic therapy in patients with saphenous vein and internal mammary artery bypass grafts: the Seventh ACCP Conference on Antithrombotic and Thrombolytic Therapy. Chest 2004 Sep;126(3 Suppl):600S-608S.
58. Li H, Gutterman DD, Rusch NJ, Bubolz A, Liu Y. Nitration and functional loss of voltage-gated K+ channels in rat coronary microvessels exposed to high glucose. Diabetes 2004 Sep;53(9):2436-42.
59. Hatoum OA, Binion DG, Miura H, Telford G, Otterson MF, Gutterman DD. Role of hydrogen peroxide in ACh-induced dilation of human submucosal intestinal microvessels. Am J Physiol Heart Circ Physiol 2005 Jan; 288(1): H48-54.
60. Slyper A, Jurva J, Pleuss J, Hoffmann R, Gutterman DD. Influence of glycemic load on HDL cholesterol in youth. Am J Clin Nutr 2005 Feb;81(2):376-9.
61. Sato A, Terata K, Miura H, Toyama K, Loberiza FR Jr, Hatoum OA, SaitoT, Sakuma I, Gutterman DD. Mechanism of vasodilation to adenosine in coronary arterioles from patients with heart disease. Am J Physiol Heart Circ Physiol 2005 Apr;288(4):H1633-40.
62. Slyper A, Le A, Jurva J, Gutterman DD. The influence of lipoproteins on whole-blood viscosity at multiple shear rates. Metabolism 2005 Jun;54(6):764-8.
63. Hogue CW Jr, Creswell LL, Gutterman DD, Fleisher LA. Epidemiology, mechanisms, and risks: ACCP guidelines for the prevention and management of post-operative atrial fibrillation after cardiac surgery. Chest. 2005 Aug;128(2 Suppl):9S-16S.
64. Epstein AE, Alexander JC, Gutterman DD, Maisel W, Wharton JM. Anticoagulation: ACCP guidelines for the prevention and management of postoperative atrial fibrillation after cardiac surgery. Chest 2005 Aug;128(2 Suppl):24S-27S.
65. Hatoum OA, Gauthier KM, Binion DG, Miura H, Telford G, Otterson MF, Campbell WB, Gutterman DD. Novel mechanism of vasodilation in inflammatory bowel disease. ATVB 2005 Nov;25(11):2355-61.
66. Hatoum OA, Binion DG, Phillips SA, O'Loughlin C, Komorowski RA, Gutterman DD, Otterson MF. Radiation induced small bowel "web" formation is associated with acquired microvascular dysfunction. Gut 2005 Dec;54(12):1797-800. PMCID: PMC1774807
67. Liu Y, Bubolz AH, Shi Y, Newman PJ, Newman DK, Gutterman DD. Peroxynitrite reduces the endothelium-derived hyperpolarizing factor component of coronary flow-mediated dilation in PECAM-1-knockout mice. Am J Physiol Regul Integr Comp Physiol 2006 Jan;290(1):R57-65.
68. Guyatt G, Gutterman DD, Baumann MH, Addrizzo-Harris D, Hylek EM, Phillips B, Raskob G, Lewis SZ, Schünemann H. Grading strength of recommendations and quality of evidence in clinical guidelines: report from an American College of Chest Physicians task force. Chest. 2006 Jan;129(1): 174-81.
69. Guyatt G, Baumann M, Pauker S, Halperin J, Maurer J, Owens DK, Tosteson AN, Carlin B, Gutterman DD, Prins M, Lewis SZ, Schünemann H. Addressing resource allocation issues in recommendations from clinical practice guideline panels: suggestions from an American College of Chest Physicians task force. Chest. 2006 Jan;129(1):182-7.
70. Larsen BT, Miura H, Hatoum OA, Campbell WB, Hammock BD, Zeldin DC, Falck JR, Gutterman DD. Epoxyeicosatrienoic and dihydroxyeicosatrienoic acids dilate human coronary arterioles via BKCa channels: implications for soluble epoxide hydrolase inhibition. Am J Physiol Heart Circ Physiol 2006 Feb;290(2): H491-9. PMCID: PMC1456013
71. Hatoum OA, Otterson MF, Kopelman D, Miura H, Sukhotnik I, Larsen BT, Selle RM, Moulder JE, Gutterman DD. Radiation induces endothelial dysfunction in murine intestinal arterioles via enhanced production of reactive oxygen species. ATVB 2006 Feb;26(2):287-94.
72. Dedkov EI, Perloff JK, Tomanek RJ, Fishbein MC, Gutterman DD. The coronary microcirculation in cyanotic congenital heart disease. Circulation 2006 Jul 18;114(3):196-200.
73. Jurva JW, Phillips SA, Syed AQ, Syed AY, Pitt S, Weaver A, Gutterman DD. The effect of exertional hypertension evoked by weight lifting on vascular endothelial function. JACC 2006 Aug 1;48(3):588-9.
74. Dhanasekaran A, Al-Saghir R, Lopez B, Zhu D, Gutterman DD, Jacobs ER, Medhora M. Protective effects of epoxyeicosatrienoic acids on human endothelial cells from the pulmonary and coronary vasculature. Am J Physiol Heart Circ Physiol 2006 Aug;291(2):H517-31.
75. Phillips SA, Hatoum OA, Gutterman DD. The mechanism of flow-induced dilation in human adipose arterioles involves hydrogen peroxide during CAD. Am J Physiol Heart Circ Physiol 2007 Jan;292(1):H93-100.
76. Baumann MH, Lewis SZ, Gutterman DD. ACCP evidence-based guideline development: a successful and transparent approach to addressing conflict of interest, funding, and patient-centered recommendations. Chest 2007 Sep;132(3): 1015-24.
77. Bubolz AH, Wu Q, Larsen BT, Gutterman DD, Liu Y. Ebselen reduces nitration and restores voltage-gated potassium channel function in small coronary arteries of diabetic rats. Am J Physiol Heart Circ Physiol 2007 Oct;293(4): H2231-7.
78. Hoch AZ, Jurva JW, Staton MA, Thielke R, Hoffmann RG, Pajewski N, Gutterman DD. Athletic amenorrhea and endothelial dysfunction. WMJ 2007 Sep;106(6):301-6.
79. Larsen BT, Gutterman DD, Sato A, Toyama K, Campbell WB, Zeldin DC, Manthati VL, Falck JR, Miura H. Hydrogen peroxide inhibits cytochrome P450 epoxygenases: interaction between two endothelium-derived hyperpolarizing factors. Circ Res 2008 Jan 4;102(1): 59-67. PMCID: PMC2364729
80. Phillips SA, Jurva JW, Syed AQ, Syed AQ, Kulinski JP, Pleuss J, Hoffmann RG, Gutterman DD. Benefit of low-fat over low-carbohydrate diet on endothelial health in obesity. Hypertension 2008 Feb;51(2):376-82. PMCID: PMC2702133. Winner of the Award for Most Significant Original Paper for 2008 in the category of Clinical Science.
81. Mio Y, Bienengraeber MW, Marinovic J, Gutterman DD, Rakic M, Bosnjak ZJ, Stadnicka A. Age-related attenuation of isoflurane preconditioning in human atrial cardiomyocytes: roles for mitochondrial respiration and sarcolemmal adenosine triphosphate-sensitive potassium channel activity. Anesthesiology 2008 Apr;108(4):612-20. PMCID: PMC2697447
82. Liu Y, Li H, Bubolz AH, Zhang DX, Gutterman DD. Endothelial cytoskeletal elements are critical for flow-mediated dilation in human coronary arterioles. Med Biol Eng Comput 2008 May;46(5):469-78. PMCID: PMC2702135
83. Harrington, RA, Becker RC, Cannon CP, Gutterman DD, Lincoff AM, Popma JJ, Steg G, Guyatt GH, Goodman SG, American College of Chest Physicians. Antithrombotic therapy for non-ST-segment elevation acute coronary syndromes: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines (8th Edition). Chest. 2008 Jun;133(6 Suppl):670S-707S.
84. Toyama K, Wulff H, Chandy KG, Azam P, Raman G, Saito T, Fujiwara Y, Mattson DL, Das S, Melvin JE, Pratt PF, Hatoum OA, Gutterman DD, Harder DR, Miura H. The intermediate-conductance calcium-activated potassium channel KCa3.1 contributes to atherogenesis in mice and humans. J Clin Invest 2008 Sep;118(9):3025-37. PMCID: PMC2496961
85. Farrell RM, Syed A, Syed A, Gutterman DD. Effects of limb electrode placement on the 12- and 16-lead electrocardiogram. J Electrocardiol 2008 Nov-Dec;41(6):536-45.
86. Zhang DX, Mendoza SA, Bubolz AH, Mizuno A, Ge ZD, Li R, Warltier DC, Suzuki M, Gutterman DD. Transient receptor potential vanilloid type 4-deficient mice exhibit impaired endothelium-dependent relaxation induced by acetylcholine in vitro and in vivo. Hypertension 2009 Mar;53(3):532-8. PMCID: PMC2694062
87. Hoch AZ, Pajewski NM, Hoffman RG, Schimke JE, Gutterman DD. Possible relationship of folic acid supplementation and improved flow-mediated dilation in premenopausal, eumenorrhiec athletic women. J Sports Science & Medicine 2009 Mar;8(1):123-9.
88. Larsen BT, Bubolz AH, Mendoza SA, Pritchard KA Jr, Gutterman DD. Bradykinin-induced dilation of human coronary arterioles requires NADPH oxidase-derived reactive oxygen species. ATVB 2009 May;29(5):739-45. PMCID: PMC2727937
89. Migrino RQ, Hari P, Gutterman DD, Bright M, Truran S, Schlundt B, Phillips SA. Systemic and microvascular oxidative stress induced by light chain amyloidosis. Int J Cardiol 2010 Nov 5;145(1):67-8. PMCID: PMC2974792
90. Bodiga S, Zhang R, Jacobs DE, Larsen BT, Tampo A, Manthati VL, Kwok WM, Zeldin DC, Falck JR, Gutterman DD, Jacobs ER, Medhora MM. Protective actions of epoxyeicosatrienoic acid: Dual targeting of cardiovascular PI3K and KATP channels. J Mol Cell Cardiol. 2009 Jun;46(6):978-88. PMCID: PMC2796716
91. Hoch AZ, Pajewski NM, Moraski L, Carrera GF, Wilson CR, Hoffmann RG, Schimke JE, Gutterman DD. Prevalence of the female athlete triad in high school athletes and sedentary students. Clin J Sport Med. 2009 Sep;19(5):421-8. PMCID: PMC2848387
92. Mendoza SA, Fang J, Gutterman DD, Wilcox DA, Bubolz AH, Li R, Suzuki M, Zhang DX. TRPV4-mediated endothelial Ca2+ influx and vasodilation in response to shear stress. Am J Physiol Heart Circ Physiol. 2010 Feb;298(2):H466-76. PMCID: PMC2822567
93. Hoch AZ, Lynch SL, Jurva JW, Schimke JE, Gutterman DD. Folic acid supplementation improves vascular function in amenorrheic runners. Clin J Sport Med. 2010 May;20(3):205-10.
94. Widlansky ME, Wang J, Shenouda SM, Hagen TM, Smith AR, Kizhakekuttu TJ, Kluge MA, Weihrauch D, Gutterman DD, Vita JA. Altered mitochondrial membrane potential, mass, and morphology in the mononuclear cells of humans with type 2 diabetes. Transl Res. 2010 Jul;156(1):15-25. PMCID: PMC2904361
95. Kizhakekuttu TJ, Gutterman DD, Phillips SA, Jurva JW, Arthur EIL, Das E, Widlansky ME. Measuring FMD in the Brachial Artery: How important is QRS-gating? J Appl Physiol. 2010 Oct;109(4):959-65. PMCID: PMC2963331
96. Miura H, Toyama K, Pratt PF Jr, Gutterman DD. Cigarette smoking impairs sodium-potassium ATPase activity in the human coronary microcirculation. Am J Physiol Heart Circ Physiol. 2011 Jan;300(1):H109-17. PMCID: PMC3023254
97. Liu Y, Bubolz AH, Mendoza S, Zhang DX, Gutterman DD. H2O2 Is the Transferrable Factor Mediating Flow-Induced Dilation in Human Coronary Arterioles. Circ Res. 2011;108:566-573. PMCID: PMC3108183
98. Phillips SA, Das E, Wang J, Pritchard KA, Gutterman DD. Resistance and aerobic exercise protects against acute endothelial impairment induced by a single exposure to hypertension during exertion. J Appl Physiol. 2011 Apr;110(4):1013-20. PMCID: PMC3075126
99. Hoch AZ, Papanek P, Szabo A, Widlansky ME, Schimke JE, Gutterman DD. Association between the female athlete triad and endothelial dysfunction in dancers. Clin J Sport Med. 2011 Mar;21(2):119-25.
100. Migrino RQ, Truran S, Gutterman DD, Franco DA, Bright M, Schlundt B, Timmons M, Motta A, Phillips SA, Hari P. Human microvascular dysfunction and apoptotic injury induced by AL amyloidosis light chain proteins. Am J Physiol Heart Circ Physiol. 2011 Sep 30. PMCID: PMC3233808
101. Gauthier KM, Olson L, Harder A, Isbell M, Imig JD, Gutterman DD, Campbell WB. Soluble epoxide hydrolase contamination of specific catalase preparations inhibits epoxyeicosatrienoic acid vasodilation of rat renal arterioles. Am J Physiol Renal Physiol. 2011 Oct;301(4):F765-72. PMCID: PMC3191800
102. Hoch AZ, Papanek P, Szabo A, Widlansky ME, Gutterman DD. Folic Acid Supplementation Improves Vascular Function in Professional Dancers With Endothelial Dysfunction. PM R. 2011 Nov;3(11):1005-12. PMCID: PMC3328806
103. Zhang DX, Borbouse L, Gebremedhin D, Mendoza SA, Zinkevich NS, Li R, Gutterman DD. H2O2-Induced Dilation in Human Coronary Arterioles: Role of Protein Kinase G Dimerization and Large-Conductance Ca2+-Activated K+ Channel Activation. Circ Res. 2012, 110(3):471-480. PMCID: PMC3272100
104. Dharmashankar K, Welsh A, Wang J, Kizhakekuttu TJ, Ying R, Gutterman DD, Widlansky ME. Nitric Oxide Synthase-Dependent Vasodilation of Human Subcutaneous Arterioles Correlates With Noninvasive Measurements of Endothelial Function. Am J Hypertens. 2012 May;25(5):528-34. PMCID: PMC3328603
105. Vandvik PO, Lincoff AM, Gore JM, Gutterman DD, Sonnenberg FA, Alonso-Coello P, Akl EA, Lansberg MG, Guyatt GH, Spencer FA Primary and Secondary Prevention of Cardiovascular Disease: Antithrombotic Therapy and Prevention of Thrombosis, 9th ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines. Chest. 2012 Feb;141(2 Suppl):e637S-68S.
106. Guyatt GH, Norris SL, Schulman S, Hirsh J, Eckman MH, Akl EA, Crowther M, Vandvik PO, Eikelboom JW, McDonagh MS, Lewis SZ, Gutterman DD, Cook DJ, Schünemann HJ. Methodology for the Development of Antithrombotic Therapy and Prevention of Thrombosis Guidelines: Antithrombotic Therapy and Prevention of Thrombosis, 9th ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines. Chest. 2012 Feb;141(2 Suppl):53S-70S.
107. Bubolz AH, Mendoza SA, Zheng X, Zinkevich NS, Li R, Gutterman DD, Zhang DX. Activation of endothelial TRPV4 channels mediates flow-induced dilation in human coronary arterioles: role of Ca2+ entry and mitochondrial ROS signaling. Am J Physiol Heart Circ Physiol. 2012 Feb;302(3):H634-42.
108. Wang J, Alexanian A, Ying R, Kizhakekuttu TJ, Dharmashankar K, Vasquez-Vivar J, Gutterman DD, Widlansky ME. Acute Exposure to Low Glucose Rapidly Induces Endothelial Dysfunction and Mitochondrial Oxidative Stress: Role for AMP Kinase. Arterioscler Thromb Vasc Biol. 2012 Mar;32(3):712-20. PMCID: PMC3319449
109. Tonelli MR, Curtis JR, Guntupalli KK, Rubenfeld GD, Arroliga AC, Brochard L, Douglas IS, Gutterman DD, Hall JR, Kavanagh BP, Mancebo J, Misak CJ, Simpson SQ, Slutsky AS, Suffredini AF, Thompson BT, Ware LB, Wheeler AP, Levy MM, on behalf of the ACCP/ATS/SCCM Working Group. An Official Multi-Society Statement: The Role of Clinical Research Results in the Practice of Critical Care Medicine. Am. J. Respir. Crit. Care Med. 2012; 185:1117-1124.
110. Freed JK, Gutterman DD. Mitochondrial reactive oxygen species and vascular function: less is more. Arterioscler Thromb Vasc Biol. 2013 Apr;33(4):673-5.
111. Patel VK, Naik SK, Naidich DP, Travis WD, Weingarten JA, Lazzaro R, Gutterman DD, Wentowski C, Grosu HB, Raoof S. A practical algorithmic approach to the diagnosis and management of solitary pulmonary nodules: part 2: pretest probability and algorithm. Chest. 2013 Mar;143(3):840-846.
112. Patel VK, Naik SK, Naidich DP, Travis WD, Weingarten JA, Lazzaro R, Gutterman DD, Wentowski C, Grosu HB, Raoof S. A practical algorithmic approach to the diagnosis and management of solitary pulmonary nodules: part 1: radiologic characteristics and imaging modalities. Chest. 2013 Mar;143(3):825-839.
113. Durand MJ, Gutterman DD. Diversity in mechanisms of endothelium-dependent vasodilation in health and disease. Microcirculation. 2013 Apr;20(3):239-47. PMCID: PMC3625248
114. Ohta M, Toyama K, Gutterman DD, Campbell WB, Lemaître V, Teraoka R, Miura H. Ecto-5'-nucleotidase, CD73, is an endothelium-derived hyperpolarizing factor synthase. Arterioscler Thromb Vasc Biol. 2013 Mar;33(3):629-36. PMCID: PMC3587694
115. Franco DA, Truran S, Burciu C, Gutterman DD, Maltagliati A, Weissig V, Hari P, Migrino RQ. Protective role of clusterin in preserving endothelial function in AL amyloidosis. Atherosclerosis. 2012 Nov;225(1):220-3. PMCID: PMC3478430
116. Kizhakekuttu TJ, Wang J, Dharmashankar K, Ying R, Gutterman DD, Vita JA, Widlansky ME. Adverse alterations in mitochondrial function contribute to type 2 diabetes mellitus-related endothelial dysfunction in humans. Arterioscler Thromb Vasc Biol. 2012 Oct;32(10):2531-9. PMCID: PMC3570053
117. Bi D, Toyama K, Lemaître V, Takai J, Fan F, Jenkins DP, Wulff H, Gutterman DD, Park F, Miura H. The intermediate conductance calcium-activated potassium channel KCa3.1 regulates vascular smooth muscle cell proliferation via controlling calcium-dependent signaling. J Biol Chem. 2013 May 31;288(22):15843-53. PMCID: PMC3668741
118. Peng Y, Yu D, Gregorich Z, Chen X, Beyer AM, Gutterman DD, Ge Y. In-depth proteomic analysis of human tropomyosin by top-down mass spectrometry. J Muscle Res Cell Motil. 2013 Aug;34(3-4):199-210. PMCID: PMC3849107
119. Rubenstein JC, Gutterman DD. A new application for CPAP in preventing atrial fibrillation. Chest. 2013 May;143(5):1198-1199.
120. Zheng X, Zinkevich NS, Gebremedhin D, Gauthier KM, Nishijima Y, Fang J, Wilcox DA, Campbell WB, Gutterman DD, Zhang DX. Arachidonic acid-induced dilation in human coronary arterioles: convergence of signaling mechanisms on endothelial TRPV4-mediated Ca2+ entry. J Am Heart Assoc. 2013 Apr 25;2(3):e000080. PMCID: PMC3698766
121. Hoch AZ, Pajewski NM, Hoffmann RG, Schimke JE, Gutterman DD. Possible relationship of folic Acid supplementation and improved flow-mediated dilation in premenopausal, eumenorrheic athletic women. J Sports Sci Med. 2009;8(1):123-9. PMCID: PMC3737801
122. Gutterman DD, Durand MJ. Vascular dysfunction in diabetes mellitus: large conductance calcium-activated potassium channels as part of a subsarcolemmal signaling soiree. Circ Res. 2014 Feb 14;114(4):588-90.
123. Carbone RG, Algahim MF, Rizzo S, Monselise A, Dart RA, Almassi GH, Gutterman DD. Cardiovascular risk in patients without known cardiovascular disease. Eur Rev Med Pharmacol Sci. 2014;18(3):365-73.
124. Freed JK, Beyer AM, LoGiudice JA, Hockenberry JC, Gutterman DD. Ceramide changes the mediator of flow-induced vasodilation from nitric oxide to hydrogen peroxide in the human microcirculation. Circ Res. 2014 Aug 15;115(5):525-32. PMCID: PMC4640193
125. Durand MJ, Gutterman DD. Exercise and vascular function: how much is too much? Can J Physiol Pharmacol. 2014 Jul;92(7):551-7. PMCID: PMC4398063
126. Durand MJ, Phillips SA, Widlansky ME, Otterson MF, Gutterman DD. The vascular renin-angiotensin system contributes to blunted vasodilation induced by transient high pressure in human adipose microvessels. Am J Physiol Heart Circ Physiol. 2014 Jul 01;307(1):H25-32. PMCID: PMC4080172
127. Beyer AM, Durand MJ, Hockenberry J, Gamblin TC, Phillips SA, Gutterman DD. An acute rise in intraluminal pressure shifts the mediator of flow-mediated dilation from nitric oxide to hydrogen peroxide in human arterioles. Am J Physiol Heart Circ Physiol. 2014 Dec 01;307(11):H1587-93. PMCID: PMC4255007
128. Durand MJ, Dharmashankar K, Bian JT, Das E, Vidovich M, Gutterman DD, Phillips SA. Acute exertion elicits a H2O2-dependent vasodilator mechanism in the microvasculature of exercise-trained but not sedentary adults. Hypertension. 2015 Jan;65(1):140-5. PMCID: PMC4268168
129. Lebovitz HE, Ludvik B, Yaniv I, Schwartz T, Zelewski M, Gutterman DD, Metacure Investigators. Treatment of Patients with Obese Type 2 Diabetes with Tantalus-DIAMOND® Gastric Electrical Stimulation: Normal Triglycerides Predict Durable Effects for at Least 3 Years. Horm Metab Res. 2015 Jun;47(6):456-62.
130. Beyer AM, Freed JK, Durand MJ, Riedel M, Ait-Aissa K, Green P, Hockenberry JC, Morgan RG, Donato AJ, Peleg R, Gasparri M, Rokkas CK, Santos JH, Priel E, Gutterman DD. Critical Role for Telomerase in the Mechanism of Flow-Mediated Dilation in the Human Microcirculation. Circ Res. 2016 Mar 04;118(5):856-66. PMCID: PMC4772813
131. Durand MJ, Murphy SA, Schaefer KK, Hunter SK, Schmit BD, Gutterman DD, Hyngstrom AS. Impaired Hyperemic Response to Exercise Post Stroke. PLoS One. 2015;10(12):e0144023. PMCID: PMC4667998
132. Ellinsworth DC, Sandow SL, Shukla N, Liu Y, Jeremy JY, Gutterman DD. Endothelium-Derived Hyperpolarization and Coronary Vasodilation: Diverse and Integrated Roles of Epoxyeicosatrienoic Acids, Hydrogen Peroxide, and Gap Junctions. Microcirculation. 2016 Jan;23(1):15-32. PMCID: PMC4707990
133. Gutterman DD, Chabowski DS, Kadlec AO, Durand MJ, Freed JK, Ait-Aissa K, Beyer AM. The Human Microcirculation: Regulation of Flow and Beyond. Circ Res. 2016 Jan 08;118(1):157-72. PMCID: PMC4742348
134. Kadlec AO, Beyer AM, Ait-Aissa K, Gutterman DD. Mitochondrial signaling in the vascular endothelium: beyond reactive oxygen species. Basic Res Cardiol. 2016 May;111(3):26. PMCID: PMC6749826
135. Durand MJ, Zinkevich NS, Riedel M, Gutterman DD, Nasci VL, Salato VK, Hijjawi JB, Reuben CF, North PE, Beyer AM. Vascular Actions of Angiotensin 1-7 in the Human Microcirculation: Novel Role for Telomerase. Arterioscler Thromb Vasc Biol. 2016 06;36(6):1254-62. PMCID: PMC4882242
136. Kadlec AO, Chabowski DS, Ait-Aissa K, Gutterman DD. Role of PGC-1α in Vascular Regulation: Implications for Atherosclerosis. Arterioscler Thromb Vasc Biol. 2016 08;36(8):1467-74. PMCID: PMC4965312
137. Durand MJ, Buchanan CE, Hoch AZ, Gutterman DD. Does Barostress On The Endothelium During Maximal Exertion Cause Endothelial Dysfunction In Healthy, Sedentary Subjects?: 707 Board #23 June 1, 3: 30 PM - 5: 00 PM. Med Sci Sports Exerc. 2016 May;48(5 Suppl 1):189-90.
138. Levi-Rosenzvig R, Beyer AM, Hockenberry J, Ben-Shushan RS, Chuyun D, Atiya S, Tamir S, Gutterman DD, Szuchman-Sapir A. 5,6-δ-DHTL, a stable metabolite of arachidonic acid, is a potential EDHF that mediates microvascular dilation. Free Radic Biol Med. 2017 02;103:87-94.
139. Beyer AM, Zinkevich N, Miller B, Liu Y, Wittenburg AL, Mitchell M, Galdieri R, Sorokin A, Gutterman DD. Transition in the mechanism of flow-mediated dilation with aging and development of coronary artery disease. Basic Res Cardiol. 2017 01;112(1):5. PMCID: PMC6758541
140. Yang L, Cheriyan J, Gutterman DD, Mayer RJ, Ament Z, Griffin JL, Lazaar AL, Newby DE, Tal-Singer R, Wilkinson IB. Mechanisms of Vascular Dysfunction in COPD and Effects of a Novel Soluble Epoxide Hydrolase Inhibitor in Smokers. Chest. 2017 Mar;151(3):555-563. PMCID: PMC5332206
141. Nishijima Y, Cao S, Chabowski DS, Korishettar A, Ge A, Zheng X, Sparapani R, Gutterman DD, Zhang DX. Contribution of K1.5 Channel to Hydrogen Peroxide-Induced Human Arteriolar Dilation and Its Modulation by Coronary Artery Disease. Circ Res. 2017 Feb 17;120(4):658-669. PMCID: PMC5315616
142. Buchanan CE, Kadlec AO, Hoch AZ, Gutterman DD, Durand MJ. Hypertension during Weight Lifting Reduces Flow-Mediated Dilation in Nonathletes. Med Sci Sports Exerc. 2017 04;49(4):669-675. PMCID: PMC5357152
143. Somberg LB, Gutterman DD, Miura H, Nirula R, Hatoum OA. Shock associated with endothelial dysfunction in omental microvessels. Eur J Clin Invest. 2017 Jan;47(1):30-37.
144. Kadlec AO, Chabowski DS, Ait-Aissa K, Hockenberry JC, Otterson MF, Durand MJ, Freed JK, Beyer AM, Gutterman DD. PGC-1α (Peroxisome Proliferator-Activated Receptor γ Coactivator 1-α) Overexpression in Coronary Artery Disease Recruits NO and Hydrogen Peroxide During Flow-Mediated Dilation and Protects Against Increased Intraluminal Pressure. Hypertension. 2017 07;70(1):166-173. PMCID: PMC5485836
145. Freed JK, Gutterman DD. Communication Is Key: Mechanisms of Intercellular Signaling in Vasodilation. J Cardiovasc Pharmacol. 2017 May;69(5):264-272. PMCID: PMC5424612
146. Zinkevich NS, Fancher IS, Gutterman DD, Phillips SA. Roles of NADPH oxidase and mitochondria in flow-induced vasodilation of human adipose arterioles: ROS-induced ROS release in coronary artery disease. Microcirculation. 2017 08;24(6). PMCID: PMC5546408
147. Durand MJ, Ait-Aissa K, Gutterman DD. Regenerative Angiogenesis: Quality Over Quantity. Circ Res. 2017 04 28;120(9):1379-1380.
148. Freed JK, Durand MJ, Hoffmann BR, Densmore JC, Greene AS, Gutterman DD. Mitochondria-regulated formation of endothelium-derived extracellular vesicles shifts the mediator of flow-induced vasodilation. Am J Physiol Heart Circ Physiol. 2017 May 01;312(5):H1096-H1104. PMCID: PMC5451582
149. Durand MJ, Ait-Aissa K, Levchenko V, Staruschenko A, Gutterman DD, Beyer AM. Visualization and quantification of mitochondrial structure in the endothelium of intact arteries. Cardiovasc Res. 2019 Aug 01;115(10):1546-1556. PMCID: PMC6648341
150. Allaqaband H, Gutterman DD, Kadlec AO. Physiological Consequences of Coronary Arteriolar Dysfunction and Its Influence on Cardiovascular Disease. Physiology (Bethesda). 2018 09 01;33(5):338-347. PMCID: PMC6230549
151. Das EK, Lai PY, Robinson AT, Pleuss J, Ali MM, Haus JM, Gutterman DD, Phillips SA. Regular Aerobic, Resistance, and Cross-Training Exercise Prevents Reduced Vascular Function Following a High Sugar or High Fat Mixed Meal in Young Healthy Adults. Front Physiol. 2018;9:183. PMCID: PMC5853082
152. Ait-Aissa K, Kadlec AO, Hockenberry J, Gutterman DD, Beyer AM. Telomerase reverse transcriptase protects against angiotensin II-induced microvascular endothelial dysfunction. Am J Physiol Heart Circ Physiol. 2018 05 01;314(5):H1053-H1060. PMCID: PMC6008150
153. Chabowski DS, Kadlec AO, Ait-Aissa K, Hockenberry JC, Pearson PJ, Beyer AM, Gutterman DD. Lysophosphatidic acid acts on LPA receptor to increase H O during flow-induced dilation in human adipose arterioles. Br J Pharmacol. 2018 11;175(22):4266-4280. PMCID: PMC6193883
154. Abraham WT, Kuck KH, Goldsmith RL, Lindenfeld J, Reddy VY, Carson PE, Mann DL, Saville B, Parise H, Chan R, Wiegn P, Hastings JL, Kaplan AJ, Edelmann F, Luthje L, Kahwash R, Tomassoni GF, Gutterman DD, Stagg A, Burkhoff D, Hasenfuß G. A Randomized Controlled Trial to Evaluate the Safety and Efficacy of Cardiac Contractility Modulation. JACC Heart Fail. 2018 10;6(10):874-883.
155. Hyngstrom AS, Murphy SA, Nguyen J, Schmit BD, Negro F, Gutterman DD, Durand MJ. Ischemic conditioning increases strength and volitional activation of paretic muscle in chronic stroke: a pilot study. J Appl Physiol (1985). 2018 05 01;124(5):1140-1147. PMCID: PMC6050199
156. Kadlec AO, Gutterman DD. The Yin and Yang of endothelium-derived vasodilator factors. Am J Physiol Heart Circ Physiol. 2018 05 01;314(5):H892-H894. PMCID: PMC6008146
157. Nishijima Y, Korishettar A, Chabowski DS, Cao S, Zheng X, Gutterman DD, Zhang DX. Shaker-related voltage-gated K channel expression and vasomotor function in human coronary resistance arteries. Microcirculation. 2018 01;25(1). PMCID: PMC5760438
158. Kadlec AO, Barnes C, Durand MJ, Gutterman DD. Microvascular Adaptations to Exercise: Protective Effect of PGC-1 Alpha. Am J Hypertens. 2018 01 12;31(2):240-246. PMCID: PMC5861535
159. Grosman-Rimon L, Wright E, Freedman D, Kachel E, Hui S, Epstein I, Gutterman D, Eilat-Adar S. Can improvement in hormonal and energy balance reverse cardiovascular risk factors in athletes with amenorrhea? Am J Physiol Heart Circ Physiol. 2019 09 01;317(3):H487-H495.
160. Ait-Aissa K, Blaszak SC, Beutner G, Tsaih SW, Morgan G, Santos JH, Flister MJ, Joyce DL, Camara AKS, Gutterman DD, Donato AJ, Porter GA Jr, Beyer AM. Mitochondrial Oxidative Phosphorylation defect in the Heart of Subjects with Coronary Artery Disease. Sci Rep. 2019 May 20;9(1):7623. PMCID: PMC6527853
161. Mahmoud AM, Hwang CL, Szczurek MR, Bian JT, Ranieri C, Gutterman DD, Phillips SA. Low-Fat Diet Designed for Weight Loss But Not Weight Maintenance Improves Nitric Oxide-Dependent Arteriolar Vasodilation in Obese Adults. Nutrients. 2019 Jun 14;11(6). PMCID: PMC6627594
162. Anker SD, Borggrefe M, Neuser H, Ohlow MA, Röger S, Goette A, Remppis BA, Kuck KH, Najarian KB, Gutterman DD, Rousso B, Burkhoff D, Hasenfuss G. Cardiac contractility modulation improves long-term survival and hospitalizations in heart failure with reduced ejection fraction. Eur J Heart Fail. 2019 Sep;21(9):1103-1113.
163. Durand MJ, Boerger TF, Nguyen JN, Alqahtani SZ, Wright MT, Schmit BD, Gutterman DD, Hyngstrom AS. Two weeks of ischemic conditioning improves walking speed and reduces neuromuscular fatigability in chronic stroke survivors. J Appl Physiol (1985). 2019 Mar 01;126(3):755-763. PMCID: PMC6459385
 
Books, Chapters, and Reviews
1. Gutterman DD, Bonham AC, Arthur JA, Gebhart GF, Marcus ML, Brody MJ: Central Neural Regulation of Coronary Blood Flow. In: Brain Peptides and Catecholamines in Cardiovascular Regulation in Normal and Disease States, J.P. Buckley and C.M. Ferrario (Eds.), Raven Press, New York, 1987.
2. Gutterman DD, Marcus ML: Advances in Understanding the Function of the Coronary Circulation in Physiological and Pathological States. In: Advances In Cardiovascular Surgery, Wechsler, A.S. (ed).
3. Gutterman DD, Bonham AC, Stuhlmuller JE, Arthur JM, Gebhart GF, Marcus ML, Brody MJ: Central Neural Aspects of Coronary Flow Regulation. In: Analysis and Simulation of the Cardiac System - Ischemia, Chapter 19, S. Sideman and R. Beyar (eds), CRC Press, Boca Raton, FL, pp. 249-264, 1989.
4. Gutterman DD, Brody MJ, Marcus ML: Neural Reg¬ulation of Coronary Blood Flow. In: Reflex Control of the Circulation, I.H. Zucker and J. Gilmore (eds), Chapter 19, CRC Press, Boca Raton, FL, pp. 695-736, 1991.
5. Gutterman DD: Central Integration of Autonomic Control of the Heart Including the Coronary Circulation. In: Volume IX: The Nervous Control of the Heart. J.T. Shepherd and S.F. Vatner (eds.), Geoffrey Burnstock (Series Ed.), Harwood Acad. Publishers, Amsterdam, pp. 253-294, 1996.
6. Gutterman DD, Schnoll D: Neural Control of the Coronary Circulation. In: Volume VIII: Nervous Control of Blood Vessels. T. Bennett and S. M. Gardiner (eds), Geoffrey Burnstock (Series Ed.), Harwood Acad. Publishers, Amsterdam, pp. 265-304, 1996.
7. Gutterman DD, Liu Y, Frisbee JC: Reactive Oxygen Species and K+ Channel Function in Diabetes and Insulin Resistance. In: Trends in Diabetes Research, Ford, A.(ed), Chapter 4, Nova Science Publishers, Inc., New York, pp. 71-106, 2006.
 
Editorials, Letters to Editor, Other
1. Gutterman DD. Characterization of the acute left ven¬tricular thrombus: hermit or nomad? J Am Coll Cardiol 1989 Mar 1;13(3):565-6.
2. Gutterman DD, Ayres RW. Use of echocardiography in detecting cardiac sources of embolus. Echocardiography 1993 Mar;10(3):311-20.
3. Lindower PD, Gutterman DD. Detection of cardioembolic sources with echocardiography. Compr Ther 1994;20(3):174-80.
4. Gutterman DD. Adventitia-dependent influences on vascular function. Am J Physiol 1999 Oct;277(4 Pt 2):H1265-72.
5. Chilian WM, Gutterman DD. Prologue: new insights into the regulation of the coronary microcirculation. Am J Physiol Heart Circ Physiol 2000 Dec;279(6):H2585-6.
6. Gutterman DD, Hume J. Potassium channels that regulate vascular tone: Which are the important players? Clin Exp Pharm Phys 2002; 29:304.
7. Liu Y, Gutterman DD. Oxidative stress and potassium channel function. Clin Exp Pharmacol Physiol 2002 Apr;29(4):305-11.
8. Gutterman DD. Vascular dysfunction in hyperglycemia: is protein kinase C the culprit? Circ Res 2002 Jan 11;90(1):5-7.
9. Liu Y, Gutterman DD. The coronary circulation in diabetes: influence of reactive oxygen species on K+ channel-mediated vasodilation. Vascul Pharmacol 2002 Jan;38(1): 43-9.
10. Konidala S, Gutterman DD. Coronary vasospasm and the regulation of coronary blood flow. Prog Cardiovasc Dis 2004 Jan-Feb;46(4):349-73.
11. Wilcox CS, Gutterman DD. Focus on oxidative stress in the cardiovascular and renal systems. Am J Physiol Heart Circ Physiol 2005 Jan;288(1):H3-6.
12. Gutterman DD, Miura H, Liu Y. Redox modulation of vascular tone: focus of potassium channel mechanisms of dilation." Arterioscler Thromb Vasc Biol 2005 Apr;25(4):671-8.
13. Gutterman DD. Mitochondria and reactive oxygen species: an evolution in function. Circ Res 2005 Aug 19;97(4):302-4.
14. Hatoum OA, Binion DG, Gutterman DD. Paradox of simultaneous intestinal ischaemia and hyperaemia in inflammatory bowel disease. Eur J Clin Invest 2005 Oct;35(10):599-609.
15. Baumann MH, Gutterman DD. American College of Chest Physicians evidence based guidelines--the next generation: considering resource use and evolution to a single grading system. Chest 2006 Jan;129(1):10-2.
16. Irwin RS, Gutterman DD. American College of Chest Physicians cough guidelines. Lancet 2006 Mar 25;367(9515):981.
17. Larsen BT, Gutterman DD, Hatoum OA. Emerging role of epoxyeicosatrienoic acids in coronary vascular function. Eur J Clin Invest. 2006 May;36(5): 293-300.
18. Larsen BT, Gutterman DD. Hypoxia, coronary dilation, and the pentose phosphate pathway. Am J Physiol Heart Circ Physiol 2006 Jun;290(6): H2169-71.
19. Mayr M, Zhang J, Greene AS, Gutterman DD, Perloff J, Ping P. Proteomics-based development of biomarkers in cardiovascular disease: mechanistic, clinical, and therapeutic insights. Mol Cell Proteomics 2006 Oct;5(10):1853-64.
20. Gutterman DD, Cowley AW Jr. Relating cardiac performance with oxygen consumption: historical observations continue to spawn scientific discovery. Am J Physiol Heart Circ Physiol 2006 Dec;291(6):H2555-6.
21. Larsen BT, Campbell WB, Gutterman DD. Beyond vasodilatation: non-vasomotor roles of epoxyeicosatrienoic acids in the cardiovascular system. Trends Pharmacol Sci 2007 Jan;28(1):32-8.
22. Zhang DX, Gutterman DD. Mitochondrial reactive oxygen species-mediated signaling in endothelial cells. Am J Physiol Heart Circ Physiol 2007 May;292(5): H2023-31.
23. Hoch AZ, Lal S, Jurva JW, Gutterman DD. The female athlete triad and cardiovascular dysfunction. Phys Med Rehabil Clin N Am 2007 Aug;18(3):385-400, vii-viii.
24. Gutterman DD. Combating nitrate tolerance - A novel endogenous mechanism. Arterioscler Thromb Vasc Biol. 2007 Aug; 27(8):1673-6.
25. Pagano PJ, Gutterman DD. The adventitia: the outs and ins of vascular disease. Cardiovasc Res 2007 Sep 1;75(4):636-9.
26. Larsen BT, Zhang DX, Gutterman DD. Epoxyeicosatrienoic acids, TRP channels, and intracellular Ca2+ in the vasculature: an endothelium-derived endothelium hyperpolarizing factor? Arterioscler Thromb Vasc Biol 2007 Dec;27(12):2496-8.
27. Liu Y, Gutterman DD. Vascular control in humans: focus on the coronary microcirculation. Basic Res Cardiol 2009 Feb 3;104:211-27. PMCID: PMC3045058
28. Gutterman DD. Silent Myocardial Ischemia. Circ J 2009 Apr 24;73(5):785-97.
29. Larsen BT, Gutterman DD. C-reactive protein: A multipronged assailant on endothelium-dependent vasodilation. J Mol Cell Cardiol 2009 Aug;47(2):177-9.
30. Guyatt G, Akl EA, Hirsh J, Kearon C, Crowther M, Gutterman DD, Zelman Lewis S, Nathanson I, Jaeschke R, Schunemann H. The Vexing Problem of Guidelines and Conflict of Interest: A Potential Solution. Ann Intern Med. 2010 Jun 1;152:738-41.
31. O'Connor PM, Gutterman DD. Resurrecting hope for antioxidant treatment of cardiovascular disease: focus on mitochondria. Circ Res. 2010 Jul 9;107(1):9-11. PMCID: PMC2929761
32. Guntupalli KK, Gutterman DD, Raoof S, Markowski PA. 2010: The Year of the Lung. Chest December 2010 138:1287-1288.
33. Zhang DX, Gutterman DD. TRP channel activation and endothelium-dependent dilation in the systemic circulation. J Cardiovasc Pharmacol. 2011 Feb;57(2):133-9. PMCID: PMC3047599
34. Widlansky ME, Gutterman DD. Regulation of endothelial function by mitochondrial reactive oxygen species. Antioxid Redox Signal. 2011 Sep 15;15(6):1517-30. PMCID: PMC3151425.
35. Zinkevich NS, Gutterman DD. ROS induced ROS release in vascular biology: redox-redox signaling. Am J Physiol Heart Circ Physiol. 2011 Sep;301(3):H647-53. PMCID: PMC3191081
36. Beyer A, Gutterman DD. Regulation of the Human Coronary Microcirculation. J Mol Cell Cardiol. 2011 Oct 12. 52:814-821. PMCID: PMC3306504
37. Guyatt GH, Akl EA, Crowther M, Schünemann HJ, Gutterman DD, Zelman Lewis S. Introduction to the Ninth Edition: Antithrombotic Therapy and Prevention of Thrombosis, 9th ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines. 2012 Feb;14 (2 Suppl):48S-52S. PMC Journal: In Process.
 
Abstracts
1. Gutterman DD, Chilian WM, Eastham CL, Inou T, Bohling BA, Marcus ML, White CW: Failure of Intracoronary Pyruvate to Salvage Myocardium after Three Hours of Myocardial Ischemia. Fed Proc, 42:1093, 1983.
2. Gutterman DD, Rusch NJ, Hermsmeyer RK, Dole WP: Differential Reactivity of Large and Small Coronary Arteries to 5 Hydroxytryptamine. Fed Proc, 43:3597, 1984.
3. Gutterman DD, Bonham AC, Arthur JM, Gebhart GF, Marcus ML, Brody MJ: Coronary Vasoconstriction to Stimulation in Brainstem Regions Receiving Nociceptive Afferent Input Fed Proc, 44(3):622, 1985.
4. Bonham AC, Arthur GF, Marcus JM, Gebhart ML, Brody MJ. Lateral hypothalamus (LH)-A central site for neurally mediated coronary vasoconstriction.
5. Arthur JM, Bonham AC, Gebhart GF, Marcus ML, Brody MJ. Stimulation in the anteromedial hypothalamus in the area of the paraventricular nucleus produces coronary vasoconstriction.
6. Bonham AC, Wilkin LD, Arthur JM, Gutterman DD, Gebhart GF, Marcus ML, Brody MJ: Brainstem Efferents from a Lateral Hypothalamic Site Which Produces a Decrease in Coronary Blood Flow. The Physiologist, 28(4):275, 1985.
7. Gutterman DD, Gebhart GF, Arthur JM, Bonham AC, Marcus ML, Brody MJ: Frequency-Dependent Selective Activation of Coronary Vasoconstriction by Electrical Stimulation in Brainstem. Clin Res, 33(4):806A, 1985.
8. Gutterman DD, Bonham AC, Gebhart GF, Marcus ML, Brody MJ: Coronary Constrictor Pathway from Lateral Hypothalamus (LH) Projects Through Ventrolateral Medulla (VLM). Fed Proc, 45(3):397, 1986.
9. Gutterman DD, Clothier J, Brody MJ: Coronary Vasoconstriction Produced by Epicardial Hypothermic Solutions. Circulation, 74(4):II-243, 1986.
10. Gutterman DD, Clothier J, Marcus ML, Brody MJ: Coronary Vascular Response to Epicardial Hypothermic Solutions. Clin Res, 34(4):894A, 1986.
11. Gutterman DD, Marcus ML, Brody MJ, Miller FJ: Parabrachial Nuclear Region: An Important Neuronal Site Mediating Coronary Vasoconstriction. Circulation, 79:II-316, 1988.
12. Gutterman DD, Miller FJ, Morgan DA: Does Myocardial Stunning Alter Neurally-Mediated Coronary Vasoconstriction? Circulation, 78:II-555, 1988.
13. Stuhlmuller JE, Gutterman DD, Marcus ML, Gebhart GF, Brody MJ: Electrical Stimulation in Rostral Ventrolateral Medulla of the Cat Produces Coronary Vasoconstrictor and Vasodilator Responses. FASEB J, 2:A495, 1988.
14. Paul RK, Gutterman DD, Marcus ML, Brody MJ: Medullary Sites Projecting to Spinal Preganglionic Neurons Mediate Coronary Constriction in Cat. Circulation, 80:II-311, 1989.
15. Gutterman DD, Pardubsky PD, Gebhart GF: Attenuation of Afferent Spinal Neuronal Responses to Successive Coronary Occlusions May Contribute to Silent Ischemia. Circulation, 80:II-553, 1989.
16. Gutterman DD, Marcus ML, Brody MJ: Participation of Parabrachial Nuclear Region in Baroreflex Coronary Vasoconstriction. FASEB J., 3:A975, 1989.
17. De Boel SL, Gutterman DD: Is Coronary Vasocon¬striction a Component of the Cerebral Ischemic Response? Circulation, 80:II-552, 1989.
18. LaMaster TS, Paul RK, Gutterman DD: Coronary Constrictor Pathway From Anterior Hypothalamus Projects Through Rostroventrolateral Medulla. Clin Res, 37:882A, 1989.
19. Gutterman DD, Ben-Haim S, Morgan DA: Brief Myocardial Ischemia Alters the Coronary Vascular Response to Vagal Stimulation. FASEB J, 4:A402, 1990.
20. Paul RK, Gutterman DD, Brody MJ. Induction of Neurogenic coronary vasoconstriction from spinal cord is asymmetrical. Circ 82: III-636, 1990.
21. Gutterman DD, Barber CE, Morgan DA. Effect of Neuropeptide Y on transmural distribution of myocardial blood flow. Circ 82 (Suppl. III): III-336, 1990.
22. Law HI, Jones LF, Brody MJ, Gutterman DD. Differential regional vascular responses to electrical and chemical activation in rostral ventrolateral medulla.
23. Cave A, Gutterman DD: Role of Cell Bodies in the Region of Parabrachial Nucleus in Baroreflex Coronary Vasoconstriction. FASEB, 1991.
24. Nair BA, Paul RK, Murad Y, Gutterman DD, Brody MJ: Does the Area Postrema Mediate Ouabain-Induced Coronary Vasoconstriction? FASEB J, 5:A1113, 1991.
25. McDermott DA, Mellen ST, Gebhart GF, Gutterman DD: Pericardial Administration of Bradykinin (BK) to Rats Produces a Receptor-Mediated Reflex Change in Mean Arterial Pressure. FASEB, 1991.
26. Cave AR, LaMaster TS, Gutterman DD: Coronary Constrictor Pathway from Anterior Hypothalamus Includes Neurons in Rostroventrolateral Medulla. American Heart Association, 64th Scientific Sessions, 1991.
27. Gutterman DD, Morgan DA, Dellsperger KC: Differential Coronary Response to Norepinephrine and Sympa¬thetic Stimulation in Diabetic Dogs. American Heart Associ¬ation, 64th Scientific Sessions. Circulation, 84:II-558, 1991.
28. Goodson AR, Liebold JM, Gutterman DD. Sustained coronary vasoconstriction during electrical activation in anterior hypothalamus in rats.
29. Dellsperger KC, Brooks LA, Eastham CL, Gutterman DD: Coronary Microvascular Vasodilator Responses in Diabetic Dogs. American Heart Association, 64th Scientific Sessions, Circulation, 84:II-557, 1991.
30. McDermott DA, Meller ST, Gebhart GF, Gutterman DD: Characterization of the Reflex Hemodynamic Response to Intrapericardial Bradykinin. FASEB J., 6:A1293, 1992.
31. Ben-Haim S, Kienzle M, Gutterman DD. Beat by beat ECG variability for detection of patients with positive electrophysiologic study.
32. Ben-Haim SA, Becker B, Kaplinsky E, Gutterman DD, Palti Y. Prediction of immediate ventricular fibrillation following by QRS variability coronary artery ligation in dogs. J Am Coll Cardiol 20: 1270-1276, 1992.
33. Goodson AR, Leibold JM, Gutterman DD: Gliben¬clamide Produces Coronary Constriction in Cat. FASEB J, 6:A1753, 1992.
34. Dellsperger KC, Brooks LA, Gutterman DD: Hyperglycemia Attenuates Coronary Microvascular Dilation to Acetylcholine. FASEB J, 6(4):A1580, 1992.
35. Goodson AR, Leibold JM, Gutterman DD: Inhibition of Nitric Oxide Synthesis Augments Centrally-Induced Sympathetic Coronary Vasoconstriction in Cats. Circulation 86(4):I-509, 1992.
36. Dellsperger KD, Brooks LA, Gutterman DD: Enhanced Coronary Microvascular Vasodilation to an ATP-Sensitive Potassium Channel Opener in Diabetes. Circulation, 86(4):I-486, 1992.
37. Gutterman DD, Leibold JM, Morgan DA: Do Oxygen-Derived Free Radicals Contribute to Neural Stunning in the Heart? Circulation, 86(4):I-689, 1992.
38. Dellsperger KC, Brooks LA, Gutterman DD. Enhanced coronary microvascular vasodilation to an ATP-sensitive potassium channel opener in diabetes.
39. Dellsperger KC, Brooks LA, Morgan DA, Gutterman DD. Adenosine responses are not impaired in the coronary circulation of diabetic dogs.
40. Pettersen MD, Morgan DA, Leibold JM, Ben-Haim S, Gutterman DD: Sustained Reduction in Coronary Constriction to Sympathetic Stimulation Following Intracoronary Adenosine. FASEB J., 7:A212, 1993.
41. Miller FJ, Dellsperger KC, Gutterman DD: Hyperglycemia Alters Endothelium Dependent Relaxation of Coronary Microvessels but not Conduit Vessels In Vitro. FASEB J., 7:A423, 1993.
42. Dellsperger KC, Brooks LA, Gutterman DD: Hyperglycemia Results in Enhanced Coronary Microvascular Responses to RP 52891. FASEB J., 7:A423, 1993.
43. Miller FJ, Dellsperger KC, Embrey RP, Gutterman DD. Acetylcholine constricts isolated human coronary resistance vessels.
44. Miller FJ, Dellsperger KC, Embrey RP, Gutterman DD. Isolated human coronary arterioles exhibit myogenic tone.
45. Miller FJ, Dellsperger KC, Embrey RP, Gutterman DD: Differential Effect of Acetylcholine on Atrial and Ventricular Resistance Vessels Isolated from Human Hearts. JACC, 2/94:427A.
46. Oltman CL, Gutterman DD, Dellsperger KC. Glycoslated hemoglobin impairs coronary microvascular responses to acetylcholine in vitro.
47. Ammar Jr RF, Gutterman DD, Dellsperger KC. Coronary microvascular responses to metabolic stimulation in diabetes.
48. Miller FJ, Dellsperger KC, Oltman CL, Gutterman DD.: Alloxan-Induced Diabetes Mellitus Impairs Endothelium Dependent Vasodilation of Canine Coronary Arterioles. Circulation, 90:I-430, 1994.
49. Abe T, Morgan DA, Gutterman DD: Specific Role of Adenosine Receptors in Mediating Post-Ischemic Dysfunction of Coronary Sympathetic Innervation. Circulation 90:I-269, 1994.
50. Ammar Jr RF, Gutterman DD, Dellsperger KC: Topically Applied Superoxide Dismutase and Catalase Normalize Coronary Arteriolar Responses to Acetylcholine in Diabetes Mellitus In Vivo. Circulation, 90:I-574, 1994.
51. Ammar RF, Gutterman DD, Dellsperger KC: Effect of Superoxide Dismutase (SOD) on Microvascular Acetylcholine (ACh) Responses in Diabetes. FASEB J., 8:A292, 1994.
52. Sundaram K, Liebold JM, Gutterman DD: Inhibition of NO Synthase Augments Sympathetic Coronary Vasoconstriction to Stellate Stimulation in Cats. FASEB J., 8:A847, 1994.
53. Abe T, Morgan DA, Gutterman DD: Post-Ischemic Dysfunction of Sympathetic Coronary Innervation Involves Adenosine Receptor Activation. FASEB J., 8:A848, 1994.
54. Rodriguez-Iglesias E, Miller FJ, Dellsperger KC, Gutterman DD: Role of Prostaglandins and Nitric Oxide in the Human Atrial Coronary Arteriolar Response to Acetylcholine. FASEB J., 10(4):A912, 1995.
55. Abe T, Morgan DA, Gutterman DD: Effects of Activating Selective Adenosine Receptors on Sympathetic Coronary Innervation. FASEB J., 9(4):A840, 1995.
56. Paul RK, Breu M, Gutterman DD. Laterality of neurogenic coronary vasoconstriction in male and female cats.
57. Abe T, Sengupta JN, Gebhart GF, Gutterman DD: Reduced Cardiac Sympathetic Afferent Activity Following Brief Ischemia. Circ, 92:I-60, 1995.
58. Abe T, Morgan DA, Gutterman DD: Protection by Nerve Growth Factor Against Postischemic Dysfunction of Sympathetic Coronary Innervation. Circ., 92:I-60, 1995.
59. Miller FJ, Dellsperger KC, Gutterman DD: Mechanism of Human Coronary Arteriolar Relaxation to Adenosine Diphosphate. Circ., 92:I-131, 1995.
60. Miller FJ, Dellsperger KC, Gutterman DD: Basal Tone of Isolated Human Coronary Arterioles Depends on Protein Kinase C Activation. Circ., 92:I-430, 1995.
61. Ammar Jr RF, Gutterman DD, Dellsperger KC. Mechanisms of impaired dilation of coronary arterioles during increases in myocardial oxygen consumption in diabetes mellitus.
62. Miura H, Chappell DA, Gutterman DD: Preserved Dilation in Carotid Arteries of Apolipoprotein (APO)E and APOE + LOL Receptor Deficient Mice. FASEB J., 10:A604, 1996
63. Scott E, Breu M, Gutterman DD: Coronary Arteriolar Response to Norepinephrine in Humans. FASEB J, 10:A47, 1996.
64. Bocker J, Chappell DC, Gutterman DD: Selective Impairment of Endothelium Dependent Vasodilation Following Responses to Oxidized Low Density Lipoprotein. FASEB J, 10:A604, 1996.
65. Oltman CL, Gutterman DD, Dellsperger KC. Role of superoxide in impaired endothelium-dependent vasodilation of coronary arterioles from diabetic dogs.
66. Miura H, McCoy DM, Gutterman DD: Human Coronary Arteriolar Relaxation to Arachidonic Acid Depends upon Cytochrome P450 Monooxygenase. Circ., 94:I-63, 1996.
67. Miura H, Miller FJ, McCoy DM, Gutterman DD: Mechanism of Human Coronary Arteriolar Relaxation to Bradykinin. Circ., 94:I-241, 1996.
68. Miller FJ, Gutterman DD, Davidson BL: Adenovirus Mediated Gene Transfer to Isolated Canine and Human Coronary Conduit and Resistance Vessels. Circ., 94:I-243, 1996.
69. Miura H, Chappell DA, Gutterman DD: Mechanisms of Impaired Endothelium-Dependent Vasodilation in Carotid Arteries of Apolipoprotein E and LDL Receptor-Deficient Mice. Circ., 94:I-425, 1996.
70. Miller FJ, Dellsperger KC, Gutterman DD: Protein Kinase C Dependent Myogenic Constriction of Isolated Human Coronary Arterioles. Circ., 94:I-489, 1996.
71. Oltman CL, Gutterman DD, Quinn KA, Bar RS, Dellsperger KC. Insulin and IGF-1 induced vasodilation in canine coronary microvessels.
72. Miura H, Gutterman DD: Role of Ca2+-Activated Potassium Channels in Human Coronary Arteriolar Relaxation to Bradykinin. FASEB J, 11:A44, 1997.
73. Murphy SL, Beasley K, Gutterman DD: Circulating Factor in Diabetic Serum Contributes to Impaired Endothelial Dependent Dilation. FASEB J, 11:A157, 1997.
74. Miller Jr FJ, Gutterman DD, Heistad DD, Davidson BL. Gene transfer of superoxide dismutase reduces superoxide anion but does not improve endothelial dependent relaxation in atherosclerosis.
75. Miller Jr FJ, Mozena JD, Gutterman DD, Davidson BL. In Situ visualization of reactive oxygen species in atherosclerosis.
76. Miura H, Breu M, Gutterman DD. Hypoxia induces human coronary arteriolar dilation via ATP-sensitive potassium channel activation. Circ 96:I-74, 1997.
77. Miura H, Gutterman DD. Human coronary arteriolar dilation to bradykinin depends upon hyperpolarization via Ca2+-activated potassium channel activation. Circ 96:I-16, 1997.
78. Miura H, Breu M, Gutterman DD. Diabetes mellitus impairs ATP-sensitive potassium channel function of human coronary arterioles. Circ 96:I-17, 1997.
79. Gutterman DD, Breu M. Flow-mediated vasodilation of human coronary arterioles does not require nitric oxide synthase. Circ 96: I-310, 1997.
80. Manthei SA, Rupert BE, Gutterman DD. Thrombin induced vasodilation does not require activation of pertussis toxin-sensitive g-proteins. FASEB J. 12:A670, 1998.
81. Miura H, Gutterman DD. Membrane hyperpolization and vasodilation of human coronary arterioles to arachidonic acid (AA) via cytochrome P450 monooxygenase (P450). FASEB J.
82. Terata K, Miura H, Gutterman DD. Potent Vasodilation to Adrenomedullin in Isolated Human Coronary Arterioles. FASEB J. 12: A405, 1998.
83. Miura H, Manthei SA, Gutterman DD. Flow-induced dilation depends upon membrane hyperpolarization via Ca2+-activated K+ (KCa) channels in human coronary arterioles. Circ 98:I-138, 1998.
84. Miller FJ, Mozena JE, Foresman EL, Davidson BL, Gutterman DD. Smooth muscle cell production of superoxide is increased in atherosclerosis. Circ 98:I-311, 1998.
85. Terata K, Yorek MA, Gutterman DD. Acetylcholine-induced arteriolar dilation mediated by K-channel is reduced in STZ-induced diabetic rats with motor nerve dysfunction. Circ 98:I-400, 1998.
86. Miller FJ, Mozena J, Foresman EL, Gutterman DD, Davidson BL. Superoxide production is increased throughout the vascular wall of atherosclerotic mice aorta and mediated by a membrane bound NADPH oxidase. Circ 98:I-733, 1998.
87. Terata K, Miller FJ, Gutterman DD. Effect of superoxide on K-channel mediated responses in human coronary arterioles. Circ 98:I-825, 1998.
88. Oltman CL, Kern TS, Brooks LA, Kane NL, Gutterman DD, Dellsperger KC. Vascular reactivity of coronary arterioles from 5 year diabetic dogs. FASEB J 13:A88, 1999.
89. Terata K, Liu Y, Gutterman DD. Minimal contribution of superoxide to myogenic constriction of rat small coronary arteries. Circulation 100:I417-I418, 1999.
90. Liu Y, Terata K, Gutterman DD. Elevated glucose generates superoxide and reduces voltage-dependent K=channel current in rat coronary artery vascular smooth muscle cells. FASEB J 14:A163, 2000.
91. Liu Y, Terata K, Nicolosi A, Gutterman DD. Peroxynitrite inhibits human coronary arteriolar dilation to activation of Ca2+-activated K+ channels. Circulation 102:II-113, 2000.
92. Liu Y, Terata K, Gutterman DD. High glucose reduces voltage-dependent K+ current by NADPH oxidase-generated superoxide. Circulation 102:II-255, 2000.
93. Terata K, Mirua H, Sato A, Liu Y, Gutterman DD. Minimal contribution of nitric oxide (NO) and Katp channels to adenosine-induced dilation of coronary arterioles in patients with coronary artery disease. Circulation 102:II-255, 2000.
94. Chai Q, Gutterman DD, Liu Y. Elevated Glucose Impairs cAMP Mediated Dilation by Reducing Voltage-dependent K+ (Kv) Channel Activity in Coronary Vascular Smooth Muscle Cells (VSMCs). FASEB Journal, V15, No. 5: A764, 2001.
95. Miura H, Sato A, Gutterman DD. K+-Induced Dilation Involves Both Na+/K+ ATPase and Inwardly Rectifying K+ Channels (KIR) in Human Coronary Arterioles. FASEB Journal, V15, No. 5: A765, 2001.
96. Sato A, Miura H, LiuY, Chai Q, Somberg LB, Eberhardt LM, Gutterman DD. Gender based differences in endothelium dependent vasodilation of human arterioles. FASEB Journal, V15, No. 5: A1122, 2001.
97. Liu Y, Chai Q, Gutterman DD. Peroxynitrite Inhibits Ca2+-Activated K+ Channel Activity in Smooth Muscle of Human Coronary Arterioles. Circulation, V104, No. 17: II-31, 2001.
98. Miura H, Sato A, Saito T, Miura M, Gutterman DD. Evidence for Multiple Endothelium-Derived Hyperpolarizing Factors in Human Coronary Arterioles. Circulation, V104, No. 17: II-39, 2001.
99. Miura H, Saito T, Miura M, Gutterman DD. Diazoxide Protects against Hypoxia/Ischemia-Induced Injury in Human Coronary Arterioles in Vitro. Circulation, V104, No. 17: II-114, 2001.
100. Miura H, Qiang C, Liu Y, Saito T, Miura M, Gutterman DD. Flow-Mediated Dilation of Human Coronary Arterioles Involves Production of Hydrogen Peroxide. Circulation, V104, No. 17: II-285-6, 2001.
101. Sato A, Miura H, Liu Y, Gutterman DD. Differential Regulation of the Human Coronary Arterioles by Adenosine Receptor Subtypes. Circulation, V104, No. 17: II-287, 2001.
102. Sato A, Miura H, Liu Y, Nicolosi AC, Sakuma I, Gutterman DD. Involvement of Intermediate Conductance Ca2+-Activated K+ Channels in Adenosine-Induced Human Coronary Arteriolar Dilation. FASEB Journal, V16, No. 5: A860, 2002.
103. Li H, Gutterman DD, Liu Y. Elevated Glucose Impairs cAMP-mediated Voltage-dependent K+ (Kv) Channel Activity in Coronary Vascular Smooth Muscle Cells (VSMCs). FASEB Journal, V16, No. 5: A860, 2002.
104. Miura H, Sato A, Saito T, Miura M, Gutterman DD. Oxidative Stress Impairs ATP-Sensitive Potassium Channel (KATP)-Mediated Dilation of Human Coronary Arterioles (HCA) in Diabetes Mellitus (DM). FASEB J, V16, No. 5: A860, 2002.
105. Liu YP, Li H, Stadnicka A, Suzuki A, Kwok W, Bosnjak Z, Gutterman DD. Differential Response of KATP Channels to Superoxide in Coronary and Cardiac Myocytes. Circulation, V106, No. 19: II-35, 2002.
106. Sato A, Miura H, Liu Y, Nicolosi A, Gutterman DD. Reactive Oxygen Species Mediate Vasodilation of Human Coronary Arterioles. Circulation, V106, No. 19: II-111, 2002.
107. Liu Y, Zhao H, Kalyanaraman B, Johnson D, Gutterman DD. Mitochondria, a Source for Generating H2O2 Plays a Key Role in Flow-Mediated Dilation in Human Coronary Arterioles. Circulation, V106, No. 19: II-171, 2002.
108. Sato A, Miura H, Liu Y, Downey FX, Gutterman DD. Oxidative Stress Enhances Human Coronary Arteriolar Dilation to Adenosine. Circulation, V106, No. 19: II-277, 2002.
109. Liu Y, Li H, Stadnicka A, Suzuki A, Kwok W, Bosnjak Z, Gutterman DD. Differential Response of KATP Channels to Superoxide in Coronary and Cardiac Myocytes. Circulation, V106, No. 19: II-35, 2002.
110. Sato A, Miura H, Liu Y, Nicolosi A, Gutterman DD. Reactive Oxygen Species Mediate Vasodilation of Human Coronary Arterioles. Circulation, V106, No. 19: II-111, 2002.
111. Liu Y, Zhao H, Li H, Kalyanaraman B, Johnson D, Gutterman DD. Mitochondria, a Source for Generating H2O2, Plays a Key Role in Flow-Mediated Dilation in Human Coronary Arterioles. Circulation, V106, No. 19: II-171, 2002.
112. Sato A, Miura H, Liu Y, Downey FX, Gutterman DD. Oxidative Stress Enhances Human Coronary Arteriolar Dilation to Adenosine. Circulation, V106, No. 19: II-277, 2002.
113. Hatoum OA, Binion DG, Otterson MF, Gutterman DD. Microvascular dysfunction in inflammatory bowel disease- IBD. FASEB Journal, V17, No. 4: A69, 2003.
114. Ou H, Ou Z, Jones DW, Ackerman AW, Hillery CA, Gutterman DD, Guice KS, Oldham KT, Pritchard KA. 4F, An Apo A-I mimetic preserves acetylcholine-induced vasodilation of carotid arterioles in sickle cell disease mice. FASEB J, V17, No. 4: A371, 2003.
115. Li H, Liu Y, Gutterman DD. High glucose causes tyrosine nitration of Kv1.2 and Kv1.5 in rat coronary arterial vascular smooth muscles cells (VSMCs). FASEB J, V17, No. 4: A505, 2003.
116. Liu Y, Li H, Gutterman DD. Complex I and III of electron transport chains play a key role in flow-mediated dilation in human coronary arterioles. FASEB J, V17, No. 4: A506, 2003.
117. Sato A, Miura H, Liu Y, Reuben C, Gutterman DD. Adenosine-induced vasodilation in coronary arterioles from subjects with diabetes: Effect of reactive oxygen species. FASEB J, V17, No. 4: A508, 2003.
118. Miura H, Saito T, Gutterman DD. Shear stress induces endothelial generation and release of hydrogen peroxide (H2O2) in human coronary arterioles (HCA). FASEB J, V17, No. 4: A509, 2003.
119. Ou J, Ou Z, Jones DW, Weihrauch D, Ackerman AW, Gutterman DD, Guice AS, Oldham KT, Pritchard KA. An Apo A-I mimetic peptide preserves vasodilation in hypercholesterolemic mice. FASEB J, V17, No. 4: A513, 2003.
120. Miura H, Sato A, Saito T, Abu-Hatoum O, Gutterman DD. Adenosine Acts as an Endothelium-Derived Hyperpolarizing Factor in Human Coronary Arteriolar Dilation to Adenosine 5'-Diphosphate. Circulation, V108, No. 17: IV-99, 2003.
121. Miura H, Saito T, Fujiwara Y, Sato A, Abu-Hatoum O, Gutterman DD. Upregulation of Intermediate Conductance Calcium-Activated Potassium Channels is Associated with Altered Human Coronary Arteriolar Reactivity. Circulation, V108, No. 17: IV-102, 2003.
122. Sato A, Miura H, Abu-Hatoum O, Bosnjac JJ, Gutterman DD. Different Mechanisms of Dilation to Extracellularly and Intracellularly Produced Hydrogen Peroxide in Human Coronary Arterioles. Circulation, V108, No. 17: IV-102, 2003.
123. Liu Y, Li H, Gutterman DD. Cytoskeletal Elements are Critical in Flow-Mediated Dilation in Human Coronary Arterioles. Circulation, V108, No. 17: IV-227, 2003.
124. Chen Y, Gao Y, Cook C, Raza A, Biller J, Gutterman DD, Medhora M, Jacobs ER. Activation of eNOS in bovine pulmonary artery endothelial cells by VEGF and 20-HETE. FASEB J, V18, No. 5: A1238, 2004.
125. Miura H, Gutterman DD. Interaction of Two Distinct Endothelium-Derived Hyperpolarizing Factors in the Human Coronary Microcirculation. Circulation, V110, No. 17: III-181, 2004.
126. Hatoum OA, Binion DG, Miura H, Bosnjak JJ, Otterson MF, Telford G, Gutterman DD. Role for hydrogen peroxide in Ach-induced dilation of human intestinal microvessels. FASEB J, Vol. 18, No. 4: A624, 2004.
127. Liu Y, Mass M, Newman DK, Newman PK, Gutterman DD. Nitric oxide plays a more predominant role in flow-mediated dilation in coronary arteries of PECAM-1-knockout mice. FASEB J, Vol. 18, No. 4: A269-270, 2004.
128. Liu Y, Gutterman DD. Cellular Origin of EDHF (H2O2) Released from Human Coronary Arterioles in Response to Shear Stress. Circ, V110, No. 17: III-76, 2004.
129. Miura H, Toyama K, Hatoum OA, Gutterman DD. Adenosine Mediates Human Coronary Arteriolar Dilation to Adenosine 5'-triphosphate (ATP). FASEB J, Vol. 19, No. 4: A688, 2005.
130. Larsen BT, Miura HM, Campbell WB, Falck JR, Gutterman DD. Epoxyeicosatrienoic acids induce vasodilation of human coronary arterioles via an iberiotoxin-sensitive mechanism. FASEB J, Vol. 19, No. 4: A727, 2005.
131. Liu Y, Bubolz AB, Newman PJ, Newman DK, Gutterman DD. Ebselen restores the endothelium derived hyperpolarizing factor (EDHF) component of coronary flow-mediated dilation in PECAM-1-knockout mice. FASEB J, Vol. 19, No. 5: A1259, 2005.
132. Hatoum OA, Binion DG, Miura H, Phillips S, Gutterman DD. Nitric oxide (NO) assessment in control and chronically inflamed inflammatory bowel disease (IBD) submucosal intestinal microvessels. FASEB J, Vol. 19, No. 5: A1265, 2005.
133. Phillips SA, Somberg LB, Otterson MF, Telford GL, Nicolosi AC, Gutterman DD. Effect of Coronary Artery Disease (CAD) on Flow Induced Dilation in Human Visceral Adipose Resistance Vessels. FASEB J, Vol. 19, No. 5: A1265, 2005.
134. Liu Y, Gutterman DD. Evidence for H2O2 as the EDHF Mediating Flow-Induced Dilation in Human Coronary Arterioles. Circulation, Vol. 112, No. 17: II-216, 2005.
135. Liu Y, Bienengraeber M, Bubolz A, Gutterman DD. High Glucose Reduces Kv1.5 Channel Activity by Disrupting Protein Translocation in Coronary Smooth Muscle Cells. Circulation, Vol. 112, No. 17: II-216, 2005.
136. Larsen BT, Otterson MF, Miura H, Phillips SA, Selle RM, Gutterman DD, Hatoum OA. Radiation impairs endothelium-dependent dilation of murine intestinal arterioles via reduction of nitric oxide by reactive oxygen species. FASEB J, V20, No. 5: A1162, 2006.
137. Bubolz AH, Wu Q, Gutterman DD, Liu Y. Ebselen Reduces Kv1 Channel Nitration and Restores Kv1 Channel Function in Diabetic Rat Coronary Arteries. FASEB J, V20, No. 4: A284, 2006.
138. Hatoum OA, Binion DG, Miura H, Larsen BT, Selle RM, Kopelman D, Gutterman DD. The complex role of hydrogen peroxide (H202) in acetylcholine-induced dilation of human mucosal intestinal microvessels. FASEB J, V20, No. 4: A282-283, 2006.
139. Miura H, Toyama K, Hatoum OA, Saito T, Gutterman DD. Down-regulation of Intermediate Conductance Calcium-activated Potassium Channel (IKCa) Inhibits Human Coronary Smooth Muscle Cell (HSMC) Proliferation. FASEB J, V20, No. 5: A1176, 2006.
140. Phillips SA, Jacquelyn KP, Syed AQ, Syed AA, Pleuss JP, Jurva JW, Gutterman DD. Do low fat and low carbohydrate diets show similar improvement in endothelial function? FASEB J, V20, No. 5: A1392, 2006.
141. Larsen BT, Miura H, Campbell WB, Gutterman DD. NADPH Oxidase-Derived Reactive Oxygen Species Reduce Cytochrome P450 Mediated Dilation of Human Coronary Arterioles. Circulation, Vol. 114, No. 18: II-246, 2006.
142. Zhang DX, Bubolz AH, Gutterman DD. Activation of TRPV4 Channels Dilates Human Coronary Arterioles: Role of Ca2+ Influx and Mitochondrial Redox Signaling. Circulation, Vol. 114, No. 18: II-247, 2006.
143. Bubolz AH, Zhang X, Liu Y, Gutterman DD. Nitric Oxide Inhibits Flow-mediated Dilation in Human Coronary Arterioles by Regulating Mitochondrial Production of Reactive Oxygen Species. Circulation, Vol. 114, No. 18: II-20, 2006.
144. Toyama K, Hatoum OA, Gutterman DD, Miura H. Role of CD73, Ecto-5' Nucleotidases, in Human Coronary Arteriolar Dilation to Adenine Nucleotides. Circulation, Vol. 114, No. 18: II-20, 2006.
145. Phillips SA, Somberg LB, Hatoum OA, Gutterman DD. Mechanisms of hydrogen peroxide induced vasoconstriction in human adipose resistance arteries. FASEB J, V21, No. 5: A491, 2007.
146. Toyama K, Saito T, Fujiwara Y, Hatoum OA, Gutterman DD, Miura H. Intermediate Conductance Calcium-activated Potassium Channel, KCa3.1, Plays an Important Role in Macrophage (MO) Migration in Atherosclerosis. FASEB J, V21, No. 6: A854, 2007.
147. Zhang DX, Bubolz AH, Gauthier KM, Campbell WB, Gutterman DD. TRPV4 channel-mediated Ca2+ entry and vasodilatation in small bovine coronary arteries. FASEB J, V21, No. 6: A859, 2007.
148. Bubolz AH, Zhang DX, Larsen BT, Gutterman DD. TRPV4 mediates flow-induced dilation in human coronary arterioles. FASEB J, V21, No. 6: A1234, 2007.
149. Phillips SA, Syed AQ, Syed AY, Das EK, Jurva JW, Gutterman DD. Resistance and aerobic exercise protects against endothelial dysfunction induced by acute exertion. FASEB J, V21, No. 6: A935, 2007.
150. Larsen BT, Phillips SA, Bubolz AH, Zielonka J, Kalyanaraman B, Gutterman DD. HPLC separation of hydroethidine products: a specific and sensitive method for quantifying microvascular superoxide. FASEB J, 2007 21:5;577.2.
151. Wittenburg AL, Phillips SA, Gutterman DD. The role of catalase and endothelium in hydrogen peroxide induced vasodilatation of human adipose arterioles. FASEB J, Late-Breaking, LB99: 2007.
152. Miura H, Toyama K, Fujiwara Y, Saito T, Hatoum OA, Gutterman DD. Intermediate-conductance Calcium-activated Potassium Channel, KCa3.1, Plays an Important role in Macrophage Migration in Atherosclerosis. Arteriosclerosis, Thrombosis, and Vascular Biology Annual Conference, Chicago, IL, 2007.
153. Larsen BT, Bubolz AH, Pritchard Jr KA, Gutterman DD. Endothelial NADPH oxidase mediates bradykinin-induced dilation of human coronary arterioles. 8th World Conference for Microcirculation, Milwaukee, WI, 2007.
154. Zhang DX, Bubolz A, Mendoza S, Gutterman DD. TRPV4 channel mediates flow-induced dilation in mouse small mesenteric arteries. FASEB J 2008 22:964.9.
155. Wittenburg AL, Phillips S, Gutterman DD. Catalase inhibition effect on exogenous hydrogen peroxide induced vasoconstriction in diseased human arterioles. FASEB J 2008 22:1148.15.
156. Mendoza SA, Gutterman DD, Bubolz A, Suzuki M, Zhang DX. Role of TRPV4 channels in agonist-induced endothelial Ca2+ entry and vasodilation: Evidence from TRPV4-deficient mice. FASEB J. 2008 22:1181.4.
157. Larsen BT, Campbell WB, Gutterman DD. 12- and 15-hydroxyeicosatetraenoic acids may function as endothelium-derived hyperpolarizing factors in the human coronary microcirculation. FASEB J. 2008 22:914.8.
158. Das EK, Gutterman DD, Phillips SA. Exercise Protects Against Endothelial Dysfunction During Oral Glucose and High Fat Load. FASEB J. 2008 22:1235.14.
159. Migrino RQ, Bright M, Pajewski N, Truran S, Gutterman DD, Hari P. Abstract 2400: Late Gadolinium Enhancement on MRI is a Prognostic Marker of Poor Survival in Light Chain Amyloidosis: Results from Long-Term Follow Up. Circulation, Oct 2008; 118: S_718.
160. Migrino RQ, Hari P, Bright M, Phillips S, Truran S, Wittenburg A, Wang J, Gutterman DD. Abstract 2401: Endothelial Dysfunction and Oxidative Stress in Human Coronary Microvasculature Following Acute Exposure to AL Amyloid Light Chains: New Mechanism of Amyloid Injury. Circulation, Oct 2008; 118: S_718 - S_719.
161. Wang J, Gutterman DD, Widlansky ME. Abstract 410: Mitochondrial Uncoupling with CCCP Reverses Acute Hyperglycemia Induced Endothelial Dysfunction in Human Arterioles Circulation, Oct 2008; 118: S_299.
162. Gutterman DD. 2008 George E. Brown Memorial Lecture--Flow-Induced Vasodilation in the Human Heart: Unique Endothelial Mechanisms and Clinical Insights Circulation, Oct 2008; 118: A_11.
163. Wittenburg AL, Mendoza SA, Zhang DX, Gutterman DD. Unmasking a role for nitric oxide in acetylcholine-induced vasodilation in diseased human coronary arterioles. FASEB J. Apr 2009 23:LB73.
164. Zinkevich NS, Wittenburg AL, Gutterman DD. Role of mitochondria in flow-induced dilation of human adipose arterioles from subjects with and without coronary artery disease. FASEB J. Apr 2009 23:1006.3.
165. Larsen BT, Miura H, Campbell WB, Gutterman DD. 12- and 15-Hydroxyeicosatetraenoic Acids (HETEs) Function as Endothelium-Derived Hyperpolarizing Factors (EDHFs) in Human Coronary Arterioles. FASEB J. Apr 2009 23:952.17.
166. Gutterman DD. Endothelial function and cardiovascular risk. Clinical Cardiology. Oct 2009 32:15.
167. Zinkevich NS, Gutterman DD. Effect of Nitric Oxide Synthase and growth conditions on hydrogen peroxide production in cultured endothelial cells during shear stress. FASEB J. April 6, 2010 24:602.6.
168. Larsen BT, Mendoza SA, Campbell WB, Gutterman DD. Lipoxygenases mediate endothelium-dependent vasodilation in the human coronary microcirculation. FASEB J. April 6, 2010 24:1028.
169. Truran S, Gutterman DD, Schlundt B, Hari P, Migrino RQ. Oxidative Stress and Apoptotic Injury Induced by Amyloidogenic Light Chain Proteins in Human Coronary Artery Endothelial Cells. AHA Scientific Sessions, Session on Microcirculation and Cerebral/Coronary/Peripheral Circulation. November 15, 2010.
170. Zinkevich NS, Wittenburg AL, Gutterman DD. Role of Cyclooxygenase in flow-induced dilation of human coronary arterioles depends upon age. Circulation. November 2010 122: A15764.
171. Larsen B, Mendoza SA, Campbell WB, Gutterman DD. Vasomotor regulation of the human coronary circulation by hydroxyepoxyeicosatrienoic and trihydroxyeicosatrienoic acids. FASEB J March 17, 2011 25:lb467.
172. Zhang DX, Mendoza SA, Gebremedhin D, Gutterman DD. H2O2 dilates human coronary arterioles by stimulating the large-conductance Ca2+-activated K+ channel activity FASEB J March 17, 2011 25:1093.5.
173. Zinkevich NS, Gutterman DD. Role of mitochondrial reactive oxygen species on flow-induced dilation in human arterioles with coronary artery disease. FASEB J March 17, 2011 25:832.8.
174. Mendoza SA, Borbouse R, Gauthier KM, Campbell WB, Gutterman DD, Zhang DX. 5,6-Epoxyeicosatrienoic acid-induced endothelium-dependent dilation of mouse mesenteric arteries: dependence on TRPV4 channel activity FASEB J March 17, 2011 25:820.7.
175. Franco D, Truran S, Gutterman DD, Georges J, Hari P, Migrino RQ. Novel mechanism of endothelial cell injury by light chain amyloidosis proteins through nuclear translocation of apoptosis inducing factor. ATVB. Chicago, IL. April 28-30, 2011.
176. Borbouse R, Gutterman DD. Influence of obesity on insulin-mediated dilation in the human microcirculation. FASEB J March 29, 2012 26:866.2.
177. Durand M, Phillips S, Gutterman DD. The Vascular Renin Angiotensin System Contributes to Endothelial Dysfunction Induced by Acute High Pressure in Human Adipose Microvessels FASEB J March 29, 2012 26:676.8.
178. Beyer A, Gutterman DD. Decreased Telomerase Activity Converts the Mechanism of FMD from NO to H2O2 in Human and Mouse Arterioles FASEB J March 29, 2012 26:676.1.
179. Zinkevich N, Zhang D, Gutterman DD. NADPH oxidase-dependent reactive oxygen species are involved in flow-induced dilation of human adipose arterioles FASEB J March 29, 2012 26:863.3.
180. Zheng X, Yoshinori N, Gutterman DD, Zhang D. Arachidonic acid-induced dilation in human coronary arterioles: role of endothelial TRPV4-mediated and membrane potential-sensitive Ca2+ entry FASEB J March 29, 2012 26:1056.3.
181. Zinkevich N, Gutterman DD, Zhang D. Role of hydrogen peroxide and epoxyeicosatrienoic acids in arachidonic acid-induced dilation of human coronary arterioles. FASEB J. April 9, 2013 27:687.12.
182. Freed J, Beyer A, and Gutterman DD. Inhibition of Neutral Sphingomyelinase Prevents High Pressure-Induced Shift in the Mediator of Endothelium-Dependent Dilation from NO to H2O2. FASEB J. April 9, 2013 27:901.1.
183. Durand M, Beyer A, Hockenberry J, Gutterman DD. Inhibition of the vascular renin-angiotensin system preserves nitric oxide-mediated vasodilation in human adipose arterioles after transient high pressure stress (676.9). FASEB J. April 2014 28:676.9.
184. Santos J, Gutterman DD, Beyer A. Mitochondrial telomerase regulates flow mediated dilation by suppressing mitochondrial derived free radical production (664.1). FASEB J. April 2014 28:664.1.
185. Freed JK, Hockenberry JC, & Gutterman DD. Manipulation of the Sphingolipid Rheostat Alters the Mediator of Flow-Induced Dilation in the Human Microcirculation. Circulation. 2014;130:A16304
186. Gupta N, Elixhauser A, Bangalore S, & Gutterman DD. Incidence and Outcomes of Hospitalizations Associated With Adverse Effects of Anticoagulation in Therapeutic Use. Circulation. 2014;130:A15647
187. Durand MJ & Gutterman DD. Mechanical Shear Stress Restores Mitochondrial Cytoarchitecture in Human Endothelial Cells Exposed to Angiotensin II by Modulating Activity of the Fission-Inducing Protein Dynamin Related Protein 1. Circulation. 2014;130:A12625
188. Sengupta J, Kannampalli P, Belligoli A, Rousso B, Ben-Haim S, Gutterman DD. Cardiac Vagal Afferent Response in Rats during Cardiac Contractility Modulation (CCM. FASEB J. April 2015 29:651.6.
189. Durand M, Gutterman DD, Beyer A. Vasodilator and Vasoprotective Actions of Angiotensin 1-7 in the Human Microcirculation – Role of Telomerase. FASEB J. April 2015 29:789.3.
190. Hockenberry J, Zinkevich N, Beyer A, Gutterman DD. Acute and Chronic Inhibition of NOS Causes a Switch in Vasodilator Mechanism from Nitric Oxide to Hydrogen Peroxide in the Human Microcirculation. FASEB J. April 2015 29:794.2.
 

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