CURRICULUM VITAE
Joseph T. Barbieri PhD
Joseph T. Barbieri PhD
Professor
Department of Microbiology and Immunology
Department of Microbiology and Immunology
OFFICE ADDRESS: |
Medical Education Building |
8701 Watertown Plank Rd |
Milwaukee, WI 53226 |
EDUCATION: |
1971 - 1975 B.S., State University of New York at Cortland, Cortland, NY |
1975 - 1980 Ph.D., University of Massachusetts at Amherst, Amherst, MA |
POSTGRADUATE TRAINING AND FELLOWSHIP APPOINTMENTS: |
1980 - 1984 Postdoctoral Fellow, Department of Microbiology, University of California at Los Angeles, Los Angeles, CA |
FACULTY APPOINTMENTS: |
1984 - 1986 Research Associate, Department of Microbiology, Harvard Medical School, Boston, MA |
1986 - Present Assistant Professor - Professor (Tenured), Department of Microbiology, Medical College of Wisconsin, 8701 Watertown Plank Rd., Milwaukee, WI 53226 |
ADMINISTRATIVE APPOINTMENTS: |
1990 - 1997 Director, Molecular and Cell Biology Graduate Program, Medical College of Wisconsin, 8701 Watertown Plank Rd., Milwaukee, WI 53226 |
2005 - Present Director, Medical Scientist Training Program, Medical College of Wisconsin, 8701 Watertown Plank Rd., Milwaukee, WI 53226 |
AWARDS AND HONORS: |
1983 - 1984 National Institutes of Health Individual Postdoctoral Fellowship |
1992 - 1997 National Institutes of Health, Research Career Development Award |
10/1996 Visiting Professor, Department of Pharmacology, University of Freiburg, Germany |
07/1998 Session leader, Gordon Conference on Microbial Pathogenesis |
09/1999 Co-organizer, 6th Midwest Microbial Pathogenesis Meeting, Milwaukee, WI |
2000 Division Lecturer, Division D, American Society for Microbiology |
05/2001 Michael Gill Lecture, Tufts Medical Center, Boston MA. |
08/2001 Lecturer, International Forum on Infection and Immunity, Osaka, Japan |
08/2001 Lecturer, ASM, Careers in Biomedical Research, Madison, WI |
2001 Division chairman, Division B, American Society for Microbiology |
06/2003 Teacher of the Year, Graduate School at the Medical College of Wisconsin |
2005 - Present Director of the Medical Scientist Training Program at MCW |
2005 - Present NCA, Accreditation Coordinator for MCW |
2006 Session leader GRC on Microbial toxins and pathogenesis |
2007 Lecturer, Closing Address at Etox13, Viterbo, Italy |
2008 Lecturer, Toxins2008, Baveno, Italy |
2008 Lecturer, NAD2008, Hamburg, Germany |
2009 Lecturer, Etox14, Strasbourg, France |
08/2010 Chair, Gordon Research Conference on Microbial toxins and pathogenesis |
2011 Chair-elect, MD-PhD Steering committee |
MEMBERSHIPS IN HONORARY AND PROFESSIONAL SOCIETIES: |
1980 - Present American Society for Microbiology |
1996 - Present Federation of the American Society of Experimental Biologists |
EDITORSHIPS/EDITORIAL BOARDS/JOURNAL REVIEWS: |
Editorship |
1997 - 2006 Infection and Immunity |
Editorial Board |
1990 - 1995 Infection and Immunity |
1997 - 2007 Molecular Microbiology |
2007 - Present Journal of Biological Chemistry |
2007 - Present Infection and Immunity |
2008 - Present Molecular Microbiology |
Journal Review |
Journal of Clinical Investigation, Biochemistry |
Journal of Bacteriology |
NATIONAL ELECTED/APPOINTED LEADERSHIP AND COMMITTEE POSITIONS: |
10/1994 - 02/2011 NIH ad-hoc reviewer |
1994 - 1997 Consultant, Upstate Biotechnology Inc. |
1995 - 1997 Consultant, Pharmacia Inc. |
10/1996 - 06/2000 member- NIH-Bacteriology and Mycology-1 Study Section |
1997 - 1999 Consultant, Promega, Inc. |
10/1998 - 06/2000 chair- NIH-Bacteriology and Mycology-1 Study Section |
05/2002 - 05/2006 ad-hoc member- NIH-NRSA study section |
03/2003 - Present ad-hoc reviewer- Oklahoma City National Memorial Institute for the Prevention of Terrorism (MIPT), Oklahoma City, OK |
07/2003 - Present ad-hoc reviewer- NIH-NCI site visit, Laboratory of Molecular Biology |
12/2003 - Present ad-hoc reviewer- Cystic Fibrosis Foundation (National) review panel |
10/2011 - 07/2015 member- NIH-HIBP (Host Interactions with Bacterial Pathogens) |
RESEARCH GRANTS/AWARDS/CONTRACTS/PROJECTS: | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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INVITED LECTURES/WORKSHOPS/PRESENTATIONS: |
Local |
J.T. Barbieri, University of Wisconsin-Madison, Sch. of Medicine, Dept. of Medical Microbiology, Madison, WI, 1989 |
J.T. Barbieri, University of Wisconsin-Stevens Point, Department of the Life Sciences, Stevens Point, WI, 1989 |
J.T. Barbieri, North-Central Branch of the ASM, Oshkosh, WI, 10/26/1992 |
J.T. Barbieri, Loyola University of Chicago, Biology Department Chicago, IL, 12/08/1993 |
J.T. Barbieri, Department of Biochemistry, University of Wisconsin, Madison, WI, 11/09/1998 |
J.T. Barbieri, Department of Biol. Sci. IL. State University, Normal, IL, 03/23/2000 |
J.T. Barbieri, North Central ASM, La Crosse, WI, 10/13/2001 |
J.T. Barbieri, University of Chicago, Committee on Microbiology, 03/17/2003 - 03/27/2003 |
J.T. Barbieri, Argonne National Laboratories, Chicago, IL, 01/17/2008 |
J.T. Barbieri, University of Illinois-Chicago, Dept of Microbiology and Immunology, Chicago, IL, 04/14/2008 |
J.T. Barbieri, Immunology and Microbiology, Rush Medical University, Chicago, IL, 05/01/2009 |
Regional |
J.T. Barbieri, United States Department of Agriculture, NADR, Ames, Iowa, 05/25/1990 |
J.T. Barbieri, University of Iowa, College of Medicine, Department of Microbiology, 03/28/1991 |
J.T. Barbieri, Symposia on the Mechanisms of Microbial Pathogenesis, Ames, IA, 06/05/1994 |
J.T. Barbieri, Wright State School of Medicine, Dept. of Biochemistry & Mol. Biology, Dayton, OH, 10/14/1994 |
J.T. Barbieri, The Ohio State University, Department of Microbiology, Columbus, OH, 01/21/1995 |
J.T. Barbieri, Midwest Conference on Bacterial Pathogenesis, Chicago, IL, 09/17/1995 |
J.T. Barbieri, University of Texas Medical School-Houston, Dept. of Microbiology, Houston, TX, 01/25/1996 |
J.T. Barbieri, Texas Southwestern Medical Center-Dallas, Dept. of Molecular Microbiology, Dallas, TX, 08/07/1996 |
J.T. Barbieri, Univ. of Oklahoma Health Science Center, Dept. of Microbiol. and Immunol., 12/02/1996 |
J.T. Barbieri, Uniform Services-Univ. of the Health Sciences, Dept of Microbiology, Bethesda, MD, 04/21/1997 |
J.T. Barbieri, National Institutes of Health, Division of Medicine, 10/22/1997 |
J.T. Barbieri, University of Kentucky, Department of Microbiology and Immunology, 01/13/1998 |
J.T. Barbieri, Washington University School of Medicine, Department of Microbiology, 04/13/1998 |
J.T. Barbieri, American Chemical Society (Wisconsin Branch), Milwaukee, WI, 04/17/1998 |
J.T. Barbieri, Dept. of Microbiology and Immunology, University of South Alabama, Mobile, AL, 01/06/1999 |
J.T. Barbieri, Dept. of Microbiol., Univ. of Texas Medical Branch at Galveston, TX, 03/30/1999 |
J.T. Barbieri, Dept. of Microbiol., Univ. of Cincinnati, Cincinnati, OH, 04/06/1999 |
J.T. Barbieri, Department of Microbiology, USUHS. Bethesda, MD, 04/12/1999 |
J.T. Barbieri, Dept. of Microbiology, Univ. of Maryland, Baltimore, MD, 04/29/1999 |
J.T. Barbieri, Virulence Mechanisms of Bacterial Pathogenesis. Ames, IA, 09/12/1999 |
J.T. Barbieri, Department of Biochemistry, University of Houston, TX, 09/29/1999 |
J.T. Barbieri, Dept. of Biol. Sciences, LSU, Baton Rouge, LA, 09/12/2000 |
J.T. Barbieri, Microbiology, University of Virginia Charlottesville, VA, 10/27/2000 |
J.T. Barbieri, Biological Sciences, University of Kansas, KS, 11/03/2000 |
J.T. Barbieri, NIH symposium to honor Dr. Martha Vaughan, Bethesda, MD, 03/09/2001 |
J.T. Barbieri, Microbiology, University of Michigan, Ann Arbor, MI, 03/29/2001 |
J.T. Barbieri, Microbiology, Uniform Services-University of Health Sciences, Bethesda, MD, 04/09/2001 |
J.T. Barbieri, Division of Infectious Disease, Fort Detrick, Fredrick, MD, 07/19/2001 |
Cold spring Harbor Symposium on Microbial Pathogenesis, NY, 10/12/2001 |
J.T. Barbieri, Microbiology, University of Minnesota, Twin Cities, MN, 02/04/2002 |
J.T. Barbieri, Microbiology, Northwestern University Medical School, Evanston, IL, 03/19/2002 |
J.T. Barbieri, Gordon Conference, Toxins and Bacterial Pathogenesis, Proctor, NH, 07/17/2002 |
J.T. Barbieri, Uniform Services -University of Health Sciences, Dept. of Microbiology, Bethesda, MD, 03/10/2003 |
J.T. Barbieri, University of Texas Southwestern Medical Center, Dept. of Microbiology, Dallas, TX, 04/15/2003 |
J.T. Barbieri, University of Washington, Seattle, Dept. of Microbiology, 05/06/2003 |
J.T. Barbieri, North American Cystic Fibrosis General Meeting, Anaheim, CA, 10/18/2003 |
J.T. Barbieri, University of North Carolina Chapel Hill, Dept. of Microbiology, Chapel Hill, NC, 11/06/2003 |
J.T. Barbieri, University of Nebraska, Lincoln, Dept of Biotechnology, Lincoln, NE, 01/28/2004 |
J.T. Barbieri, University of Texas at San Antonio, Department of Microbiology, San Antonio, TX, 03/11/2004 |
J.T. Barbieri, Central Missouri State University, Department of Biology, Warrensburg, MO, 03/26/2004 |
J.T. Barbieri, University of Colorado Health Science Center, Microbiology, Denver, CO, 04/29/2004 |
J.T. Barbieri, Harvard Medical School, Microbiology, Boston, MA, 10/12/2004 |
J.T. Barbieri, Yale Medical School, Department of Microbiology, New Haven, CT, 12/16/2004 |
University of Louisville, Department of Microbiology, Louisville, KY, 03/03/2005 |
J.T. Barbieri, Dept. of Microbiology, Univ. of West Virginia School of Medicine, Morgantown, WV, 11/30/2005 |
J.T. Barbieri, Tuft School of Veterinary Medicine, North Grafton, MA, 03/15/2006 |
J.T. Barbieri, American Thoracic Society, San Diego, CA, 05/23/2006 |
J.T. Barbieri, University of Massachusetts, Department of Biochemistry, Amherst, MA, 09/26/2006 |
J.T. Barbieri, University of Massachusetts, Department of Microbiology, Amherst, MA, 02/03/2007 |
J.T. Barbieri, The Scripps Research Institute, La Jolla, CA, 04/19/2007 |
J.T. Barbieri, Tuft School of Veterinary Medicine, North Grafton, MA, 05/07/2007 |
J.T. Barbieri, University of Colorado Health Science Center, Microbiology, Denver, CO, 07/30/2007 |
J.T. Barbieri, Cystic Fibrosis Foundation, Bethesda, MD, 01/30/2008 |
J.T. Barbieri, Food and Drug Administration, Bethesda, MD, 05/06/2008 |
J.T. Barbieri, University of Texas-El Paso, El Paso, TX, 10/23/2009 |
J.T. Barbieri, Indiana University, Bloomington, IN, 11/10/2009 |
J.T. Barbieri, SUNY Stonybrook, Stony Brook, NY, 11/23/2009 |
J.T. Barbieri, University of Oklahoma Health Science Center, Oklahoma City, OK, 12/07/2009 |
J.T. Barbieri, SACNAS (Soc. for Advancement of Chicanos & Native Americans in Science), Anaheim, CA, 09/30/2010 |
J.T. Barbieri, ABRCMS (Annual Biomedical Research Conference for Minority Students), Charlotte, NC, 10/11/2010 |
J.T. Barbieri, Uniform Services University, Bethesda, MD, 03/28/2011 |
National |
J.T. Barbieri, General Meetings of the American Society for Microbiology, Atlanta, GA, 05/17/1993 |
J.T. Barbieri, Symposia on Bacterial ADP-ribosylating Exotoxins. ASM, Washington, DC, 05/22/1995 |
J.T. Barbieri, North-Central Branch of the ASM, Milwaukee, WI, 10/11/1996 |
J.T. Barbieri, American Society for Microbiology, Seminar speaker, Atlanta, GA, 05/19/1998 |
J.T. Barbieri, American Thoracic Society, General Meetings, San Diego, CA, 04/24/1999 |
J.T. Barbieri, American Society for Microbiology, Los Angeles, CA, 05/22/2000 |
J.T. Barbieri, ASM General Meetings, Salt Lake City, UT, 05/20/2002 |
J.T. Barbieri, National Meeting of the RCE (Regional Centers for Excellence), Washington, DC, 04/19/2004 |
J.T. Barbieri, NIAID, Boutlinum Toxin Investigators Meeting. Bethesda, MD, 10/26/2004 |
J.T. Barbieri, NIAID, Product Development Seminar. Chicago, IL, 08/15/2006 |
J.T. Barbieri, ASM, Philadelphia, PA, 05/18/2009 |
J.T. Barbieri, NRCE Meeting Las Vegas NV, 04/12/2010 |
J.T. Barbieri, NRCE Meeting on Bacterial Toxins, Bethesda MD, 09/24/2010 |
J.T. Barbieri, NRCE Meeting Denver, CO, 04/04/2011 |
International |
J.T. Barbieri, Fifth International Symposium on Bacterial Toxins, The Netherlands, 07/03/1991 |
J.T. Barbieri, Pasteur Institute, Department of Microbiology, Paris, France, 07/05/1991 |
J.T. Barbieri, Department of Pharmacology, University of Freiburg, Germany, 11/16/1996 |
J.T. Barbieri, ETOX-9, Nice, France, 07/06/1999 |
J.T. Barbieri, Dept. of Pharmacol. Freiburg University, Freiburg, Germany, 04/11/2000 |
J.T. Barbieri, Dept. of Microbiology. Freiburg University, Freiburg, Germany, 05/08/2001 |
J.T. Barbieri, Symposium on Infection and Immunity, Osaka, JAPAN, 08/20/2001 |
J.T. Barbieri, International Pseudomonas Meeting (2003) Quebec City, Quebec, CANADA, 09/07/2003 |
J.T. Barbieri, German Research Foundation, Department of Cell Biology, Brauschweig, Germany, 03/04/2004 |
J.T. Barbieri, Department of Pharmacology, University of Freiburg, Germany, 04/05/2005 |
J.T. Barbieri, Department of Microbiology, University of Munich, Germany, 04/06/2005 |
J.T. Barbieri, ETOX-12, Canterbury, UK, 06/27/2005 |
J.T. Barbieri, Japanese Society for Microbiology, Japan, 03/28/2006 |
J.T. Barbieri, Second Annual Priority Meeting on the Actin Cytoskeleton, Germany, 06/09/2006 |
J.T. Barbieri, Hanover Medical School, Department of Toxicology, Hanover, Germany, 11/20/2007 |
J.T. Barbieri, Toxins-2008, Lake Baveno, Italy, 06/14/2008 |
J.T. Barbieri, University of London Cancer Research, London, England, 09/09/2010 |
J.T. Barbieri, Royal Society of England, London, England, 09/10/2010 |
J.T. Barbieri, University of Umea, Umea, Sweden, 12/13/2010 |
J.T. Barbieri, ETOX-15, Oslo, Norway, 06/21/2011 |
COMMITTEE SERVICE: |
Medical College of Wisconsin |
1989 - 1992 Member, Research Affairs Committee, Medical College of Wisconsin |
1990 - 1994 Member, Strategic Planning Committee, Medical College of Wisconsin |
1990 - 1997 Director, Molecular and Cell Biology Graduate Program, Medical College of Wisconsin |
1995 - 2010 Member, Steering Committee for Core Facilities, Medical College of Wisconsin |
1995 Member, Steering Committee for North Central Accreditation of the Graduate School, Medical College of Wisconsin |
1995 Member, Strategic Planning Committee for Education, Medical College of Wisconsin |
1996 - 1997 Member, Steering Committee for Health Research Center, Medical College of Wisconsin |
1997 Member, Committee for Implementation of Communications at MCW (Strategic Plan), Medical College of Wisconsin |
1999 - 2003 Member, Rank and Tenure, Medical College of Wisconsin |
1999 - 2000 Internal Reviewer, the Medical Scientist Training Program, Medical College of Wisconsin |
2000 Strategic Planning Committee for MCW. |
2000 - 2003 Member, Faculty Affairs and Benefits, Medical College of Wisconsin |
2000 - 2005 Associate Director, the Medical Scientist Training Program, Medical College of Wisconsin |
2002 - 2003 Chair, Rank and Tenure, Medical College of Wisconsin |
2002 - 2004 Member, Department of Biochemistry Chairperson Search, Medical College of Wisconsin |
2004 - 2006 Member, the GCRC Review Committee, Medical College of Wisconsin |
2005 - Present Member, Institutional Biosafety Committee (IBC), Medical College of Wisconsin |
2005 - Present Director, Medical Scientist Training Program, Medical College of Wisconsin |
2006 - 2010 Member, Institutional Animal Care and Use Committees (IACUC) |
2006 - Present ASM Graduate Microbiology Teaching Award Nominating Committee |
2007 - Present GREAT MD/PhD Communications Committee of the AAMC (Chair) |
2009 - Present Member, Steering Committee Physician Scientist Pathway, Medical College of Wisconsin |
2011 - Present Member, Rank and Tenure Evaluation Committee, Medical College of Wisconsin |
MEDICAL COLLEGE TEACHING ACTIVITIES: |
Medical Student Education |
1987 - Present Yearly 6-8 lectures Bacteriology in Medical Microbiology 201 |
Graduate Student Education |
Yearly- 4 lecture in: Core IDP Introductory Course, Protein evolution and Ras GTPases. |
Every other year-2 lectures in: Cellular Microbiology, Bacterial and Toxins |
Every other year-12 lectures in: Toxin and Mucosal Cell Interactions: Toxin Action |
Yearly- lecture in: Techniques in Mol. and Cell Biology, Protein: Protein interactions. |
Yearly, 4 lectures in: Protein Chemistry, Protein Analysis |
MCW STUDENTS, FACULTY, RESIDENTS AND CLINICAL/RESEARCH FELLOWS MENTORED: |
Medical Students |
Brian Moloney, MCW, 06/1989 - Present |
Lacey Wilmot, MCW, 2001 ROADS |
Andrew Chin, MCW, 2002 ROADS |
Victor Wang, MCW, 06/2004 - Present |
Courtney Nelson, MCW, 2005 ROADS |
Neil Anderson, MCW, 06/2006 - Present |
Neha Hasan, MCW, 2007 ROADS |
Joseph Toolin, MCW, 2009 - 2010 ROADS |
Ebony Carson, MCW, 2011 ROADS |
Graduate Students |
PhD Students Advised |
Galen Cortina, MCW, 1988 - 1991 Mapping Functional Regions of the S1 Subunit of Pertussis Toxin. |
Kathleen M. Krueger, MCW, 1989 - 1994 MCW, Multiple Roles of the Carboxyl-terminus of the S1 subunit of Pertussis Toxin. |
Yiru Xu, MCW, 1990 - 1995 Analyses of Structure-Function Properties & Entry Mechanisms of Pertussis Toxin. |
Scott M. Kulich, MCW, 1991 - 1995 Characterization of Exoenzyme S from Pseudomonas aeruginosa. |
David A. Knight, MCW, 1993 - 1998 Characterization of P.aeruginosa Exoenzyme S Functional Domains, Extracellular Targets, Activation by FAS. |
Jay Radke, MCW, 1995 - 1998 The Molecular Characterization of Active Site Amino Acids of Exoenzyme S of Pseudomonas. |
Anand Ganesan, MCW, 1996 - 1999 Pseudomonas aeruginosa exoenzyme S, a bacterial ADP-ribosyltransferase that inhibits Ras signal transduction. |
Rebecca Krall Thill, MCW, 1998 - 2003 Modulation of Rho signal transduction by bacterial Rho GAPS. |
Matthew Riese, MCW, 1999 - 2002 Auto-ADP-ribosylation and host protein targeting by Pseudomonas aeruginosa ExoS. |
Jianjun Sun, MCW, 1999 - 2004 Host protein targeting by Pseudomonas aeruginosa ExoS and ExoT ADP-ribosyltransferases. |
Anthony Maresso, MCW, 2000 - 2005 Pseudomonas aeruginosa ExoS: Characterization of In Vivo Targets of ADP-ribosylation. |
Yue (Ray) Zhang, MCW, 2001 - 2006 Intracellular trafficking of Pseudomonas aeruginosa ExoS within mammalian cells. |
Qing (Daisy) Deng, MCW, 2003 - 2008 Molecular and Cellular Pathogenesis of Pseudomonas type III cytotoxins, ExoS/ExoT. |
James Henkel, MCW, 2003 - 2009 Biochemical Characterization of Botulinum Neurotoxin A subtypes A3 and A4. |
Chen Chen, MCW, 2004 - 2010 Tetanus Toxin Binding and Entry into Neurons. |
Abby Kroken, MCW, 2008 - Present |
Andrew Karalewitz, MCW, 2008 - Present |
Faith Blum, MCW, 2009 - Present |
Nathan Simon, MCW, 2010 - Present |
PhD Committees |
Katherine Schmalzer, MCW, 2007 - Present |
Soonyean Hwang, MCW, 2007 - Present |
Tyce Kearl, MCW, 2008 - Present |
Steven Leonardo, MCW, 2008 - Present |
Daniel Bretl, MCW, 2009 - Present |
Alexsia Richards, MCW, 2009 - Present |
Laura Ristow, MCW, 2009 - Present |
Stephanie Rolsma, MCW, 2009 - Present |
Karen V. Evangelista, MCW, 2009 - Present |
Kristin Aicher Barr, MCW, 2009 - Present |
Angela M. Henschel, MCW, 2010 - Present |
Residents |
Brucew Banwart, MD, MCW, 2000 - 2002 |
Aparna Rao, MD, MCW, 2004 - 2010 |
Shimoni Dehari, MD, MCW, 2010 - Present |
Faculty |
Viviane Finck-Barbancon, MD, MCW, 1994 - 1996 |
Suyan Liu, PhD, MCW, 1995 - 1996 |
Kristin J. Pederson, PhD, MCW, 1996 - 2001 |
Reinhold Mueller, PhD, MCW, 1997 - 1998 |
Sangita Pal, PhD, MCW, 1999 - 2000 |
Michael Baldwin, PhD, MCW, 2003 - 2009 |
Sheng Chen, PhD, DVM, MCW, 2004 - 2009 |
Srividya Suryanarayana, PhD, MCW, 2009 - 2010 |
BIBLIOGRAPHY |
Refereed Journal Publications/Original Papers |
1. Barbieri, J.T., Cox, C.D.: Glucose incorporation by Treponema pallidum. Infect. Immun. 25:291 293. 1979. |
2. Barbieri, J.T., Cox, C.D.: Pyruvate oxidation by Treponema pallidum. Infect. Immun. 25:157 163, 1979. |
3. Barbieri, J.T., Austin, F., Cox, C.D.: Distribution of glucose incorporated into macromolecular material by Treponema pallidum. Infect. Immun. 31:1171 1177, 1981. |
4. Barbieri, J.T., Cox, C.D.: Influence of oxygen on respiration and glucose catabolism by Treponema pallidum. Infect. Immun. 31:992 997, 1981. |
5. Austin, F.E., Barbieri, J.T., Corin, R.E., Grigas, K.E., Cox, C.D.: Distribution of superoxide dismutase, catalase and peroxidase activities among Treponema pallidum. Infect. Immun. 33:372 379, 1981. |
6. Barbieri, J.T, Carroll, S.F., McCloskey, J.A.: An endogenous dinucleotide bound to diphtheria toxin: adenylyl (3',5') uridine 3' monophosphate. J. Biol. Chem. 256:12247 12251, 1981. |
7. Collins, C.M., Barbieri, J.T., Collier, R.J.: Interactions of diphtheria toxin and adenylyl (3',5') uridine 3' monophosphate. J. Biol. Chem. 259:15154 15155, 1984. |
8. Tweten, R., Barbieri, J.T., Collier, R.J.: Diphtheria toxin: effect of substituting aspartic acid for glutamic acid 148 on ADP ribosyltransferase activity. J. Biol. Chem. 260:10392 10394,1985. |
9. Carroll, S.F., Barbieri, J.T., Collier, R.J.: Dimeric form of diphtheria toxin: Purification and Characterization. Biochemistry. 25:2425 2430, 1986. |
10. Barbieri, J.T., Collins, C.M., Collier, R.J.: Diphtheria Toxin can simultaneously bind to its receptor and Adenylyl (3',5') uridine 3' Monophosphate. Biochemistry 25:6608 6611, 1986. |
11. Barbieri, J.T., Rappuoli, R., Collier, R.J.: Expression of the S 1 catalytic subunit of pertussis toxin in Escherichia coli. Infect. Immun. 55:1323 1325, 1987. |
12. Barbieri, J.T., Collier, R.J.: Expression of a full length mutant form of diphtheria toxin in Escherichia coli. Infect. Immun. 55:1647 1651, 1987. |
13. Barbieri, J.T., Cortina, G.: ADP ribosyltransferase mutations in the catalytic S 1 subunit of Pertussis toxin. Infect. Immun. 56:1934 1941, 1988. |
14. Barbieri, J.T., Moloney, B., Mende Mueller, L.: Expression and secretion of the S 1 subunit of pertussis toxin in Escherichia coli. J. Bacteriol. 171:4362 4369, 1989. |
15. Cortina, G., Barbieri, J.T.: Role of Trp 26 in the ADP ribosyltransferase reaction of Pertussis toxin. J. Biol. Chem. 264:17322 28, 1989. |
16. Barbieri, J.T., Mende Mueller, L., Rappuoli, R., Collier, R.J.: Photolabelling Glu 129 of the S 1 subunit of Pertussis toxin. Infect. Immun. 57:3549 3554, 1989. |
17. Pizza, M., Covacci, A., Bartoloni, A., Perugini, M., Nencioni, M., De Magistris, M., Villa, L., Nucci, D., Manetti, R., Bugnoli, M., Giovannoni, F., Oliveri, R., Barbieri, J.T., Sato, H., Rappuoli, R.: Characterization of a recombinant toxoid of pertussis toxin. Mutants of Pertussis toxin suitable for vaccine development. Science. 247:477 500, 1989. |
18. Barbieri, J.T., Pizza, M., Cortina, G., Rappuoli, R.: Biochemical and biological properties of recombinant S 1 subunit of pertussis toxin. Infect. Immun. 58:999-1003, 1990. |
19. Cortina, G., Barbieri, J.T.: Localization of a region of the S1 subunit of pertussis toxin required for efficient ADP-ribosyltransferase activity. J. Biol. Chem. 266:3022-3030, 1991. |
20. Krueger, K., Mende-Mueller, L., Barbieri, J.T.: Protease treatment of pertussis toxin identifies a protease sensitive region of the S1 subunit. J. Biol. Chem. 266: 8122-8128, 1991. |
21. Cortina, G., Krueger, K.M., Barbieri, J.T.: The carboxyl terminus of the S1 subunit of pertussis toxin confers high affinity binding to transducin. J. Biol. Chem. 266: 23810-23814, 1991. |
22. Sandaken, M.G., Runquist J.A., Barbieri, J. T., Miziorko, H.M.: Identification of the phosphoribulokinase sugar phosphate-binding domain. Biochemistry, 31: l3715-13719, 1992. |
23. Barbieri, J.T., Armellini, D., Molkentin, J., Rappuoli, R.: Construction of a DTA-C180 peptide fusion-protein which elicits a neutralizing antibody response against diphtheria toxin and pertussis toxin. Infect. Immun. 60:5071-5077, 1992. |
24. Kulich, S.M., Frank, D.W., Barbieri, J.T.: Purification and characterization of exoenzyme S from Pseudomonas aeruginosa 388. Infect. Immun. 61:307-313, 1993. |
25. Krueger, K.M., Barbieri, J.T.: Molecular mechanism for the in vitro activation of pertussis toxin by ATP. J. Biol. Chem 268:12570-12578, 1993. |
26. Xu, Y., Barbieri, J.T.: Biochemical analysis of mutations at Tyrosine 98 of the S1 Subunit of Pertussis Toxin. Biochemistry. 33: 573-1579, 1994. |
27. Xu, Y., Barbançon-Finck, V., Barbieri, J.T.: Role of histidine 35 of the S1 subunit of pertussis toxin in the ADP-ribosylation of transducin. J. Biol. Chem. 269: 9993-9999. 28.Krueger, K.M. and Barbieri, J.T. 1994. Functional mapping of the carboxyl-terminus of the S1 subunit of pertussis toxin. Infect. and Immun. 62:2071-2078, 1994. |
28. Kulich, S.M., Yahr, T., Mende-Mueller, L., Barbieri, J.T., Frank, D.W.: Cloning the structural gene encoding exoenzyme S of Pseudomonas aeruginosa. J. Biol. Chem. 269:10431-10437, 1994. |
29. Kulich, S.M., Frank, D.W., Barbieri, J.T.: Expression of recombinant exoenzyme S of Pseudomonas aeruginosa. Infect. Immun. 63:1-8, 1995. |
30. Barbançon-Finck, V. Barbieri, J.T.: ADP-ribosylation of the αi3C20 peptide by deletion peptides of the S1 subunit of pertussis toxin. Biochemistry. 34:1050-1055, 1995. |
31. Xu, Y., Barbieri, J.T.: Pertussis toxin-mediated ADP-ribosylation of target proteins in Chinese Hamster Ovary cells involves a vesicle trafficking mechanism. Infect Immun. 63:825-832, 1995. |
32. Knight, D.A., Finck-Barbançon,V., Kulich, S.M., Barbieri, J.T.: Functional domains of Pseudomonas aeruginosa exoenzyme S. Infect Immun. 63:3182-3186, 1995. |
33. Xu, Y., Barbieri, J.T.: Pertussis toxin-catalyzed ADP-ribosylation of Gi-2 and Gi-3 in CHO cells is modulated by inhibitors of intracellular trafficking. Infect. Immun. 64:593-599, 1996. |
34. Yahr, T., Barbieri, J.T., Frank, D.W.: Genetic relationship between the 53-kDa and 49-kDa forms of exoenzyme S from Pseudomonas aeruginosa. J. Bacteriol. 178:1414-1419, 1996. |
35. Finck-Barbançon, V., Barbieri, J.T.: Preferential processing of the S1 subunit of CHO cell-associated pertussis toxin. Mol. Microbiol. 22. 87-95, 1996. |
36. Liu. S., Yahr, T., Frank, D.W., Barbieri, J.T.: Biochemical relationships between the 53 kilodalton (Exo53) and 49 kilodalton (ExoS) forms of Exoenzyme. J. Bacteriol. 179. 1609 1613, 1997. |
37. Masuda, I., Halligan, B.D., Barbieri, J.T., Haas, A.L., Ryan, L.M., McCarty, D.J.: Molecular cloning and expression of a porcine chondrocyte nucleotide pyrophosphohydrolase. Gene, 197(1-2):277-287, 1997. |
38. Knight, D.A., Barbieri, J.T.: Ecto-ADP-ribosyltransferase activity of Pseudomonas aeruginosa exoenzyme S. Infect Immun. 65:3304 3309, 1997. |
39. Truitt, R., Mueller, R., Hanke, C., Radke, J., Barbieri, J.T.: Glycosphingolipids as novel targets for T cell suppression by the B subunit of recombinant heat labile enterotoxin. Infect Immun. 66:1299 1308, 1998. |
40. Ganesan, A.K., Frank, D.W., Misra, R.P., Schmidt, G., Barbieri, J.T.: Pseudomonas aeruginosa Exoenzyme S ADP-ribosylates Ras at multiple sites. J Biol. Chem. 273:7332 7337, 1998. |
41. Schultz, J.J., Hsu, A.K., Barbieri, J.T., Li, P-L, Gross, G.J.: Pertussis toxin abolishes the cardioprotective effect of ischemic preconditioning in the intact rat heart. Am. J. Physiol. 275:495-500, 1998. |
42. Pederson, K., Barbieri, J.T.: Intracellular expression of the ADP-ribosyltransferase domain of Pseudomonas Exoenzyme S is cytotoxic to eukaryotic cells. Mol. Microbiol. 30:751-760, 1998. |
43. Yahr, T.L., Vallis, A.J., Hancock, M.K., Barbieri, J.T., Frank, D.W.: ExoY, a novel adenylate cyclase secreted by Pseudomonas aeruginosa type III system. Proc. Natl. Acad. Sci., U.S.A. 95: 13899-13904, 1998. |
44. Radke, J., Pederson K.J., Barbieri, J.T.: Pseudomonas aeruginosa exoenzyme S is a biglutamic acid ADP-ribosyltransferase. Infect. Immun. 67: 1508-1510, 1999. |
45. Ganesan, A.K., Mende-Mueller, L., Sultzer, J., Barbieri, J.T. Pseudomonas aeruginosa Exoenzyme S, a double ADP-ribosyltransferase, resembles vertebrate mono-ADP-ribosyltransferases. J. Biol. Chem, 274: 9503-9508, 1999. |
46. Vallis, A. J., Yahr, T.L., Barbieri, J.T., Frank, D.W.: Regulation of ExoS production by Pseudomonas aeruginosa in response to tissue culture conditions. Infect. Immun. 67:914-920, 1999. |
47. Knight, D.A., Barbieri, J.T.: Allosteric activation of Pseudomonas aeruginosa Exoenzyme S by FAS. Biochemistry, 38:5858-5863, 1999. |
48. Pederson, K.J., Vallis, A.J., Aktories, K., Frank, D.W., Barbieri, J.T.: The amino-terminal domain of ExoS, a bifunctional toxin, disrupts actin filaments via a mechanism which involves small-molecular-weight-GTP binding proteins. Molec Microbiol. 32(2):393-402, 1999. |
49. Masters, S.C., Pederson, K.J., Zhang, L., Barbieri, J.T., Fu., H.: Interaction of 14-3-3 with a nonphosphorylated protein ligand, exoenzyme S of Pseudomonas aeruginosa. Biochemistry, 38:(16): 5216-5221, 1999. |
50. Ganesan, A.G., Olson, J, Vincent, T., Barbieri, J.T.: Pseudomonas aeruginosa exoenzyme S inhibits guanine nucleotide exchange factor-stimulated nucleotide exchange of Ras. J. Biol. Chem. 274:21323-21829, 1999. |
51. Zhang L., Wang H., Masters S.C., Wang B., Barbieri J.T., Fu H.: Residues of 14-3-3 zeta required for activation of exoenzyme S of Pseudomonas aeruginosa. Biochemistry. 38(37):12159-12164, 1999. |
52. Goehring, U.-M., Schmidt, G., Pederson, K.J., Aktories, K., Barbieri, J.T.: The N-terminal domain of Pseudomonas aeruginosa Exoenzyme S is a GTPase-activating Protein for Rho GTPases. J. Biol. Chem., 274: 36369-36372, 1999. |
53. Pederson, K.J., Pal, S., Vallis, A.J., Frank, D.W., Barbieri, J.T.: Intracellular Localization and Processing of Pseudomonas aeruginosa ExoS in Eukaryotic Cells. Molec Microbiol, 37:287-299, 2000. |
54. Blocker, D., Barth, H., Maier, E., Benz, R., Barbieri, J.T., Aktories, K.: The C terminus of component C2II of Clostridium botulinum C2 toxin is essential for receptor binding. Infect. Immun. 68(8):4566-4573, 2000. |
55. Krall, R., Schmidt, G., Aktories, K., Barbieri, J.T.: Pseudomonas aeruginosa ExoT is a GTPase activating protein for Rho GTPases. Infect. Immun. 68(10): 6066-6068, 2000. |
56. Masuda I., Iyama K-I., Halligan, B.D., Barbieri J.T., Haas, A.L., McCarty, D.J., Ryan, L.M.: Variations in site and levels of expression of chondrocyte nucleotidepyrophosphohydrolase with aging. J Bone Mineral Res. 16(5):868-875, 2001. |
57. Würtele, M., Wolf, E., Pederson, K.J., Buchwald, B., Ahmadian, R.M., Barbieri, J.T., Wittinghofer, A.: How the Pseudomonas aeruginosa ExoS toxin down regulates Rac. Nature Structural Biology, 8(1):23-6, 2001. |
58. Riese, M.J., Wittinghofer A., Barbieri, J.T.: ADP-ribosylation of Arg41 of Rap by ExoS inhibits the ability of Rap to interact with its guanine nucleotide exchange factor, C3G. Biochemistry, 42(11):3289-94, 2001. |
59. Wurtele, M., Renault, L., Barbieri, J.T., Wittinghofer, A., Wolf, E.: Structure of the ExoS GTPase activating domain. FEBS Letters. 491(1-2): 26-29, 2001. |
60. Moss, J., Ehrmantraut, M.E., Banwart, B.D., Frank, D.W., Barbieri, J.T.: Sera from adult patients with cystic fibrosis contain antibodies to Pseudomonas aeruginosa type III apparatus. Infect. Immun. 69:1185-8, 2001. |
61. Banwart, B., Splaingard, M., Farrell, P., Moss, J., Ehrmantraut, M.E., Frank, D.W., Barbieri, J.T.: Acute infections of infants with Cystic Fibrosis by Pseudomonas aeruginosa expressing the Type III cytotoxin ExoS. J.I.D. 185:269-70, 2002. |
62. Krall, R., Sun, J.J., Pederson, K.J., Barbieri, J.T.: In vivo modulation of Rho GTPases by Pseudomonas aeruginosa ExoS. Infect. Immun. 70:360-367, 2002. |
63. Riese, M.J., Barbieri, J.T.: Membrane localization contributes to the in vivo ADP-ribosylation of Ras by Pseudomonas aeruginosa ExoS. Infect. Immun. 70: 2230-2, 2002. |
64. Riese, M.J., Goehring, M., Ehrmantraut, M., Moss, J., Aktories, K., Barbieri, J.T., Schmidt, G.: Auto-ADP-ribosylation of Pseudomonas aeruginosa ExoS. J. Biol. Chem. 277: 12082-8, 2002. |
65. Pederson, K.J., Krall, R., Riese, M.J., Ning, G., Barbieri, J.T.: Intracellular localization modulates targeting of ExoS, a type-III cytotoxins, to eukaryotic signaling proteins. Mol. Microbio. 46(5):1381-1390, 2002. |
66. Maresso, A.M., Barbieri, J.T.: Purification and characterization of two recombinant forms of the type-III cytotoxin, ExoS. Protein Purification Expression. 26:432-437, 2002. |
67. Fraylick J.E., Riese M.J., Vincent T.S., Barbieri J.T., Olson J.C.: ADP-ribosylation and functional effects of Pseudomonas exoenzyme S on cellular RalA. Biochemistry. 41(30):9680-7, 2002. |
68. Sun, J-J., Barbieri, J.T.: Pseudomonas aeruginosa ExoT ADP-ribosylates CT10-regulator of kinase (Crk) proteins. J of Biol Chem. 278(35):32794-800, 2003. |
69. Maresso A.W., Riese M.J., Barbieri J.T.: Molecular heterogeneity of a type III cytotoxin, Pseudomonas aeruginosa exoenzyme S. Biochemistry. 42(48):14249-57, 2003. |
70. Krall R., Zhang Y., Barbieri J.T.: Intracellular Membrane Localization of Pseudomonas ExoS and Yersinia YopE in Mammalian Cells. J Biological Chem. 279(4):2747-53, 2004. |
71. Sun, J-J., Maresso, A.W., Kim, J., Barbieri, J.T.: How bacterial ADP-ribosylating toxins recognize substrates. Nature: Struct Molec Biology, 11(9):868-76, 2004. |
72. Baldwin, M.R., Bradshaw, M., Johnson, E.A., Barbieri, J.T.: The C terminus of Botulinum Neurotoxin Type A Light Chain Contributes to Solubility, Catalysis, and Stability. Protein Expr Purif. 37(1):187-95, 2004. |
73. Maresso, A.W., Baldwin, M.R., Barbieri, J.T.: ERM proteins are high affinity targets for ADP-ribosylation by P. aeruginosa ExoS. J Biol Chem. 279(37):38402-8, 2004. |
74. Sun, J-J., Barbieri, J.T.: ExoS Rho GTPase-activating protein activity stimulates reorganization of the actin cytoskeleton through Rho GTPase guanine nucleotide disassociation inhibitor. J Biol Chem. 279(41):42936-44, 2004. |
75. Rao, A.R., Splaingard, M.S., Gershan, W.M., Havens, P.L., Thill, A., Barbieri, J.T.: Detection of Pseudomonas aeruginosa type III antibodies in children with tracheostomies. Ped. Pul. 39(5):402-7, 2005. |
76. Baldwin, M.R., Tepp, W.H., Pier, C.L., Bradshaw, M., Ho, M., Wilson, B.A., Fritz, R.B., Johnson, E.A., Barbieri, J.T.: Characterization of the Antibody Response to the Receptor Binding Domain of Botulinum Neurotoxin Serotypes A and E. Infect. Immun. 73(10):6998-7005, 2005. |
77. Zhang, Y, Barbieri, J.T.: A Leucine rich motif targets the Pseudomonas type-III cytotoxin ExoS for intracellular transport to Golgi-ER. Infect. Immun.73(12):7938-45, 2005. |
78. Corech, R., Rao, A., Laxova, A., Moss, J., Rock, M.J., Li, Z., Kosorok, M.R., Splaingard, M.L., Farrell, P.M., Barbieri, J.T.: Early Immune Response to the Type-III System of Pseudomonas aeruginosa in Children with Cystic Fibrosis. J Clin Microbiol. 43(8):3956-62, 2005. |
79. Deng, Q., Sun, J-J., Barbieri, J.T.: Uncoupling Crk-signal transduction by Pseudomonas ExoT. J. Biol Chem. 280(43):35953-60, 2005. |
80. Chen S., Barbieri J.T.: Unique substrate recognition by botulinum neurotoxins serotypes A and E. J. Biol Chem. 281(16):10906-11, 2006. |
81. Boldt, G.E., Kennedy, J.P, Hixon, M.S, McAllister, L.A, Barbieri, J.T, Tzipori S., Janda, K.D.: Synthesis, characterization and development of a high-throughput methodology for the discovery of botulinum neurotoxin a inhibitors. J Comb Chem. 8(4):513-21, 2006. |
82. Fu, Z., Chen, S., Baldwin, M.R., Boldt, G.E., Crawford, A., Janda, K.D., Barbieri, J.T, Kim, JJ.: Structures of the Light Chain of Botulinum Neurotoxin Serotype A Bound to Small Molecule Inhibitors. Biochemistry 45(29):8903-11, 2006. |
83. Fang, H., Luo, W., Henkel, J., Barbieri, J.T., Green, N.: A Novel Yeast Assay Probes the Interaction between Botulinum Neurotoxin, Serotype B, and Its SNARE Substrate Proc Natl Acad Sci USA. 103(18):6958-63, 2006. |
84. Maresso, A.W., Deng, Q., Pereckas, P.S., Wakim, B.T., Barbieri, J.T.: Pseudomonas aeruginosa ExoS ADP-ribosyltransferase inhibits ERM phosphorylation. Cell Microbiol. 9(1):97-105, 2007. |
85. Eubanks, L.M., Hixon, M.S., Jin, J., Hong, S., Clancy, C.M., Tepp, W.P., Malizio, C.J., Goodnough, M.C., Baldwin, M.R., Barbieri, J.T., Johnson, E.A., Boger, D.L., Dickerson, T.J., Janda, K.D.: High Throughput Identification of Botulinum Neurotoxin A Antagonists: An In Vitro and In Vivo Disconnect. Proc Natl Acad Sci USA. 104(8):2602-7, 2007. |
86. Baldwin M.R., Barbieri, J.T.: Association of Botulinum neurotoxin serotypes A and B with synaptic vesicle protein complexes, Biochemistry. 46(11):3200-3210, 2007. |
87. Sheng C., Kim, J.P., Barbieri, J.T.: Mechanism of Substrate Recognition by Botulinum Neurotoxin Serotype A. J Biol Chemistry. 282(13):9621-9627, 2007. |
88. Zhang, Y., Deng, Q., Barbieri, J.T.: Localization of type III delivered Pseudomonas ExoS to late endosome vesicles. J. Biol Chem; 282(17):13022-32, 2006. |
89. Zhang, Y., Deng, Q., Porath, J.A., Williams, C.L., Pederson, K.J., Barbieri, JT.: Plasma membrane localization affects the specificity of type-III delivered Pseudomonas ExoS RhoGAP. Cell Microbiol. 9(9):2192-201, 2007. |
90. Chen, S., Barbieri, J.T.: Multi-pocket recognition of SNAP25 by botulinum neurotoxin serotype E. J. Biol Chem. 282(35):25540-7, 2007. |
91. Deng, Q., Zhang, Y., Barbieri, J.T.: Intracellular trafficking of Pseudomonas ExoS, a type III cytoxin. Traffic. 8(10):1331-45, 2007. |
92. Pier, C.L, Tepp, W.H, Bradshaw, M., Johnson, E.A, Barbieri, JT, Baldwin MR.: A recombinant Holo-toxoid Vaccine against Botulism. Infect Immun. 76(1):437-42, 2008. |
93. Baldwin, M.R., Hill, A., Tepp, W.H., Pier, C., Bradshaw, M., Johnson, E.A., Barbieri J.T.: A subunit vaccine that protects against the seven serotypes of botulism. Infect. Immun. 76(3):1314-8, 2008. |
94. Deng, Q., Barbieri, J.T.: Modulation of host cell endocytosis by the type III cytotoxin, Pseudomonas ExoS. Traffic. 9(11):1948-57, 2008. |
95. Chen, S., Hall, C., Barbieri, J.T.: Substrate recognition of VAMP-2 by botulinum neurotoxin B and tetanus neurotoxin. J Biol Chem. 283(30):21153-9, 2008. |
96. Chen, C., Baldwin, M.R., Barbieri, J.T.: The molecular basis for the binding of tetanus toxin to co-receptors. Biochemistry. 47(27):7179-86, 2008. |
97. Henkel, J.S, Jacobson, M., Tepp, W., Pier, C., Johnson, E.A, Barbieri J.T.: Catalytic Properties of Botulinum Neurotoxin Subtypes A3 and A4. Biochemistry. 24;48(11):2522-8, 2009. |
98. Fu, Z., Chen, C., Barbieri, J.T, Kim, J.J, Baldwin, M.R.: Glycosylated SV2 and gangliosides as dual receptors for botulinum neurotoxin serotype F. Biochemistry. 2009 Jun 23;48(24):5631-41, 2009. PMID: 19476346. |
99. Chen, S., Barbieri, J.T.: Engineering botulinum neurotoxin to extend therapeutic intervention. Proc Natl Acad Sci USA, Jun 9;106(23):9180-4, 2009. PMID: 19487672. |
100. Rao, A.R, Laxova, A., Farrell, P.M, Barbieri, J.T.: Proteomic identification of OprL as a seromarker for initial diagnosis of Pseudomonas aeruginosa infection of patients with cystic fibrosis. J Clin Microbiol. Aug;47(8):2483-8, 2009. PMID: 19553571. |
101. Chen, C., Fu, Z., Kim, J.J, Barbieri, J.T, Baldwin, M.R.: Gangliosides as high affinity receptors for tetanus neurotoxin. J Biol Chem. 284(39):26569-77, 2009. PMID: 19602728. |
102. Salzameda, N.T, Barbieri, J.T, Janda, K.D.: Synthetic substrate for application in both high and low throughput assays for botulinum neurotoxin B protease inhibitors. Bioorg Med Chem Lett. 19(20):5848-50, 2009. PMID: 19747823. |
103. Capková, K., Hixon, M.S, Pellett, S., Barbieri, J.T, Johnson, E.A, Janda, K.D.: Benzylidene cyclopentenediones: First irreversible inhibitors against botulinum neurotoxin A's zinc endopeptidase. Bioorg Med Chem Lett. 20(1):206-8, 2010. PMID: 19914829. |
104. Stowe, G.N, Silhár. P., Hixon, M.S, Silvaggi, N.R, Allen, K.N, Moe, S.T, Jacobson, A.R, Barbieri, J.T, Janda, K.D.: Chirality holds the key for potent inhibition of the botulinum neurotoxin serotype a protease. Org Lett. 12(4):756-9, 2010. PMID: 20092262. |
105. Silhár, P., Capková, K., Salzameda, N.T, Barbieri, J.T, Hixon, M.S, Janda, K.D.: Botulinum neurotoxin A protease: discovery of natural product exosite inhibitors. J Am Chem Soc. 10; 132(9) 2868-9, 2010. PMID: 20158239. |
106. Henkel, J.S, Baldwin, M.R, Barbieri, J.T.: Toxins from bacteria. EXS. 100:1-29, 2010. PMID: 20358680. |
107. Schmitt, J., Karalewitz, A., Benefield, D.A, Mushrush, D.J, Pruitt, R.N, Spiller, B.W, Barbieri, J.T, Lacy, D.B.: Structural analysis of botulinum neurotoxin type G receptor binding. Biochemistry. 49 (25):5200-5, 2010. PubMed PMID: 20507178 |
108. Karalewitz, A.P, Kroken, A.R, Fu, Z, Baldwin, M.R., Kim, J.J, Barbieri, J.T.: Identification of a unique ganglioside binding loop within botulinum neurotoxins C and D-SA. Biochemistry. 49 (37): 8117-26, 2010. PMID: 20731382 |
109. Angus, A.A, Evans, D.J, Barbieri, J.T, Fleiszig, S.M.: The ADP-ribosylation domain of Pseudomonas aeruginosa ExoS is required for membrane bleb niche formation and bacterial survival within epithelial cells. Infect Immun. 78(11):4500-10, 2010. PubMed PMID: 20732998. |
110. Eubanks, L.M, Silhár. P., Salzameda. N.T, Zakhari, J.S., Xiaochuan, F., Barbieri. J.T., Shoemaker, C.B., Hixon, M.S., Janda, K.D: Identification of a Natural Product Antagonist against the Botulinum Neurotoxin Light Chain Protease. ACS Med Chem Lett. 1(6):268-272, 2010. PMID: 20959871. |
111. Pier, C.L., Chen, C., Tepp, W.H., Lin, G., Janda, K.D, Barbieri. J.T, Pellett, S., Johnson, E.A. Botulinum neurotoxin subtype A2 enters neuronal cells faster than subtype A1. FEBS Lett. 585(1):199-206, 2011. PubMed PMID: 21126520. |
112. Chen, S., Barbieri, J.T.: Association of Botulinum Neurotoxin Serotype A Light Chain with Plasma Membrane-bound SNAP-25. J Biol Chem. 286(17):15067-72, 2011. PubMed PMID: 21378164. |
113. Kroken, A.R, Karalewitz, A.P, Fu. Z., Baldwin, M.R., Kim, J-J., Barbieri, J.T.: Unique Ganglioside Binding by Botulinum Neurotoxins C and D-SA. FEBS J. 10.1111/j.1742-4658, 2011. PubMed PMID: 21554541. |
114. Kroken AR, Karalewitz AP, Fu Z, Kim JJ, Barbieri JT. Novel Ganglioside-mediated Entry of Botulinum Neurotoxin Serotype D into Neurons.J Biol Chem. 2011 Jul 29;286(30):26828-37. Epub 2011. PMID: 21632541. |
115. Henkel JS, Tepp WH, Przedpelski A, Fritz RB, Johnson EA, Barbieri JT. Subunit vaccine efficacy against Botulinum neurotoxin subtypes. Vaccine. 2011 Aug 10 [Epub ahead of print] PMID: 21839134. |
116. Hritonenko V, Mun JJ, Tam C, Simon NC, Barbieri JT, Evans DJ, Fleiszig SM. Adenylate cyclase activity of Pseudomonas aeruginosa ExoY can mediate bleb-niche formation in epithelial cells and contributes to virulence. Microb Pathog. 2011. [Epub ahead of print] PMID: 21843628. |
117. Blum FC, Barbieri JT. Exotoxins Encyclopedia of Microbiology. 1 January 2019:197-205. |
118. Chen S, Barbieri JT. Protease activity of the botulinum neurotoxins Molecular Aspects of Botulinum Neurotoxin. 1 January 2014:171-189. |
119. Rolsma S, Frank DW, Barbieri JT. Pseudomonas aeruginosa toxins The Comprehensive Sourcebook of Bacterial Protein Toxins. 5 June 2015:133-160. |
120. Barbieri JT. Damage by microbial toxins Schaechter's Mechanisms of Microbial Disease: Fifth Edition. 8 July 2013:127-140. |
121. Barbieri JT. Damage by microbial toxins Schaechter's Mechanisms of Microbial Disease: Fifth Edition. 15 May 2012:127-139. |
122. Chen S, Karalewitz AP, Barbieri JT. Insights into the different catalytic activities of Clostridium neurotoxins. Biochemistry. 2012 May 08;51(18):3941-7. PMCID: PMC3542401 |
123. Barbieri JT. Exotoxins Encyclopedia of Microbiology. 1 January 2009:355-364. |
124. Eubanks LM, Hixon MS, Jin W, Hong S, Clancy CM, Tepp WH, Baldwin MR, Malizio CJ, Goodnough MC, Barbieri JT, Johnson EA, Boger DL, Dickerson TJ, Janda KD. Erratum: An in vitro and in vivo disconnect uncovered through high-throughput identification of botulinum neurotoxin A antagonists (Proceedings of the National Academy of Sciences of the United States of America (2007) 104, 8, (2602-2607) DOI: 10.1073/pnas.0611213104) Proceedings of the National Academy of Sciences of the United States of America. 10 April 2007;104(15):6490. |
125. Maresso AW, Frank DW, Barbieri JT. Pseudomonas aeruginosa toxins The Comprehensive Sourcebook of Bacterial Protein Toxins. 2006:257-269. |
126. Fang H, Luo W, Henkel J, Barbieri J, Green N. A yeast assay probes the interaction between botulinum neurotoxin serotype B and its SNARE substrate. Proc Natl Acad Sci U S A. 2006 May 02;103(18):6958-63. PMCID: PMC1447522 |
127. Barbieri JT, Frank DW, Kulich SM. Pseudomonas aeruginosa nucleic acids encoding exoenzymes activity and use thereof in detecting pseudomonas aeruginosa infection Biotechnology Advances. 1997;15(3-4):723. |
128. Pizza M, Covacci A, Bartoloni A, Perugini M, Nencioni L, De Magistris MT, Villa L, Nucci D, Manetti R, Bugnoli M. Mutants of pertussis toxin suitable for vaccine development. Science. 1989 Oct 27;246(4929):497-500. |
129. Fedde K, Barbieri J, Collier RJ, Sly WS. Intracellular transport and processing of diptheria toxin (DT) in BSC-1 cells Federation Proceedings. 1985;44(5):6123. |
130. Przedpelski A, Tepp WH, Pellett S, Johnson EA, Barbieri JT. A Novel High-Potency Tetanus Vaccine. mBio. 2020 Aug 11;11(4). PMCID: PMC7439469 |
131. Zuverink M, Barbieri JT. Resolving the Molecular Steps in Clostridial Neurotoxin Light Chain Translocation. J Exp Neurol. 2020;1(4):123-134. PMCID: PMC7894615 |
132. Gardner A, Tepp WH, Bradshaw M, Barbieri JT, Pellett S. Resolution of Two Steps in Botulinum Neurotoxin Serotype A1 Light Chain Localization to the Intracellular Plasma Membrane. Int J Mol Sci. 2021 Oct 15;22(20). PMCID: PMC8539409 |
133. Yang C, Barbieri JT, Dahms NM, Chen C. Multiple Domains of Staphylococcal Superantigen-like Protein 11 (SSL11) Contribute to Neutrophil Inhibition. Biochemistry. 2022 Apr 05;61(7):616-624. PMCID: PMC9817067 |
134. Chang MJ, Ollivault-Shiflett M, Schuman R, Ngoc Nguyen S, Kaltashov IA, Bobst C, Rajagopal SP, Przedpelski A, Barbieri JT, Lees A. Genetically detoxified tetanus toxin as a vaccine and conjugate carrier protein. Vaccine. 2022 Aug 19;40(35):5103-5113. PMCID: PMC10336728 |
135. Gardner AP, Barbieri JT, Pellett S. How Botulinum Neurotoxin Light Chain A1 Maintains Stable Association with the Intracellular Neuronal Plasma Membrane. Toxins (Basel). 2022 Nov 22;14(12). PMCID: PMC9783275 |
136. Tepp WH, Bradshaw M, Gardner AP, Kaufman RL, Barbieri JT, Pellett S. Botulinum Neurotoxin A4 Has a 1000-Fold Reduced Potency Due to Three Single Amino Acid Alterations in the Protein Receptor Binding Domain. Int J Mol Sci. 2023 Mar 16;24(6). PMCID: PMC10055998 |
137. Gardner A, Barbieri JT. Light Chain Role in Action of Botulinum Toxins/Clostridial Neurotoxins Handbook of Neurotoxicity, Second Edition. 1 January 2023;2:1145-1154. |
138. Barbieri JT, Pederson KJ. Bacterial toxins in disease production Virulence Mechanisms of Bacterial Pathogens. 1 June 2022:163-174. |
Books, Chapters, and Reviews |
1. Krueger, K.M., Barbieri, J.T.: The family of bacterial ADP-ribosylating exotoxins. Clinical Microbiology Reviews, 8:34-47, 1995. |
2. Krueger, K.M., Barbieri, J.T.: Bacterial ADP-ribosylating exotoxins. In: Virulence mechanisms of bacterial pathogens, Ed, J.A. Roth et al., ASM Press. Washington, D.C. pp. 321-342, 1995. |
3. Barbieri, J.T., Frank, D.W.: Exoenzyme S, a bifunctional cytotoxin. In: Handbook of Experimental Pharmacology, Ed, K.Aktories and I. Just, Springer-Verlag, Berlin, Germany, 1998. |
4. Barbieri, J.T.: Exotoxins. In: Encyclopedia of Microbiology, Ed. J. Lederberg, Academic Press, San Diego, CA, 1998. |
5. Barbieri, J.T., Pederson, K.J.: Bacterial toxins in disease production. In: Virulence Mechanisms of Bacterial Pathogenesis. ASM, Washington, DC, 1999. |
6. Barbieri, J.T. Pseudomonas aeruginosa exoenzyme S, a bifunctional type-III secreted cytotoxin. In: Int. J. Med. Microbiology. 290:69-80, 2000. |
7. Barbieri, J.T., Riese, M.J., Aktories, K.: Bacterial toxins that modify the actin cytoskeleton. Annu. Rev. Cell. Dev. Biol. 18: 315-344, 2002. |
8. Barbieri, J.T.: Exotoxins. In: Encyclopedia of Microbiology, Ed. J. Lederberg, Academic Press, San Diego, CA, 2003. |
9. Barbieri, J.T., Burns, D.: 2003. Bacterial ADP-ribosylating Exotoxin. In: Bacterial Protein Toxins. Ed. Burns, D., Barbieri, J.T., Iglewski, B., and Rappuoli, R. ASM Press, Washington, DC, 2003. |
10. Burns, D., Barbieri, J.T.: Dangerous uses of bacterial toxins. In: Bacterial Protein Toxins. Ed. Burns, D., Barbieri, J.T., Iglewski, B., and Rappuoli, R. ASM Press, Washington, DC, 2003. |
11. Barbieri, J.T. Sun, JJ, Aktories, K.: Bacterial toxins that modulate the actin cytoskeleton. In: Microbial toxin-A critical Review, Ed. Thomas Profit. Horizon Scientific Press, 2004. |
12. Barbieri, J.T.: Damage by Microbial Toxins. In: Schaecter's Mechanisms of Microbial Disease. Ed. Carrie Engleberg and Victor DiRita. Lippincott Williams and Wilkins, 2004. |
13. Barbieri, J.T., Sun, J-J.: Pseudomonas ExoS and ExoT. Rev Physiol Biochem Pharmacol 152:79-92, 2004. |
14. Baldwin, M.J., Barbieri, J.T.: The type-III cytotoxins of Yersinia and Pseudomonas aeruginosa that modulate the actin cytoskeleton. In: Current Topics in Microbiology and Immunology, Edited by P. Boquet and E. Lemichezl, 2005. |
15. Maresso, AM, Frank, DW, Barbieri, JT.: Pseudomonas aeruginosa toxins. In: The Comprehensive Sourcebook of Bacterial Protein Toxins, Third Edition Edited by Joseph E. Alouf and Michel R. Popoff. Academic Press (London), 2005. |
16. Aktories, K., Barbieri, J.T.: Bacterial cytotoxins: targeting eukaryotic switches. Nat Rev Microbiol, 2005. |
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