CURRICULUM VITAE
Jyoti N. Sengupta PhD
Jyoti N. Sengupta PhD
Professor
Department of Medicine
Division of Gastroenterology
Department of Medicine
Division of Gastroenterology
OFFICE ADDRESS: |
MACC Fund Research Center |
8701 Watertown Plank Rd |
Milwaukee, WI 53226 |
EDUCATION: |
1973 - 1975 Bachelor of Science (BSc), Physiology, University of Calcutta, India |
1976 - 1977 Master of Science (MSc), Physiology, University of Calcutta, India |
1983 - 1985 Ph.D in Physiology, University of Calcutta, India |
POSTGRADUATE TRAINING AND FELLOWSHIP APPOINTMENTS: |
1985 - 1986 Postdoctoral Fellow, College of Pharmacy, Ohio State University, Columbus, OH |
1986 - 1990 Research Associate, Gastroenterology, Harvard Medical School/Beth Israel Hospital, MA |
1991 - 1997 Assistant Research Scientist, Pharmacology, University of Iowa, IA |
FACULTY APPOINTMENTS: |
1990 - 1991 Instructor, Medicine, Harvard Medical School/Beth Israel Hospital, MA |
1998 - 2000 Associate Director, Gastroenterology, AstraZeneca, Molndal, Sweden |
2000 - 2005 Assistant Professor, Medicine, Gastroenterology & Hepatology, Medical College of Wisconsin, Milwaukee, WI |
2004 - 2014 Associate Professor (Secondary appointment), Pediatric Gastroenterology, Medical College of Wisconsin, Milwaukee, WI |
2006 - 2014 Associate Professor, Medicine, Gastroenterology & Hepatology, Medical College of Wisconsin, Milwaukee, WI |
2013 - Present Faculty, F1000, UK |
2015 - Present Professor, Medicine, Gastroenterology & Hepatology, Medical College of Wisconsin, Milwaukee, WI |
2015 - Present Professor, Pediatric Gastroenterology, Medical College of Wisconsin, Milwaukee, WI |
ADMINISTRATIVE APPOINTMENTS: |
2014 - 2019 Committee member of Institutional Animal Care & Use Committee, Medical College of Wisconsin, Milwaukee, WI |
EDUCATIONAL ADMINISTRATIVE APPOINTMENTS: |
2009 - Present Faculty Member of Neuroscience PhD Committee, Medical College of Wisconsin, Milwaukee, WI |
AWARDS AND HONORS: |
1977 - 1979 Junior Research Fellow, University Grants Commission of India |
1980 - 1983 Senior Research Fellow, University Grants Commission of India |
1985 Research Associate , University Grants Commission of India |
2003 Recipient of Senior Basic Science Research Scientist Award, International Foundation of Functional Gastrointestinal Disorders (IFFGD) |
2009 Recipient of 2009 Best Basic Science Research Scientist of Fucntional Brain-Gut Society |
MEMBERSHIPS IN HONORARY AND PROFESSIONAL SOCIETIES: |
1991 - Present International Association for Study of Pain (IASP) |
1991 - Present Society for Neuroscience (SFN) |
1998 - Present American Physiological Society (APS) |
2001 - Present American Motility Society (AMS) |
2017 - Present American Urology Association (AUA) |
EDITORSHIPS/EDITORIAL BOARDS/JOURNAL REVIEWS: |
Editorial Board |
Editor, Special Topic Chapters: Visceral Pain: Recent Knowledge and Advancement, Frontiers Neuroscience |
Associate Editor, Frontiers of Neuroscience |
Journal Review |
Journal of Neuroscience |
Journal of Neurogastroenterology and Motility |
Journal of Gastroenterology & Hepatology |
Autonomic Neuroscience |
Journal of Pain |
American Journal of Physiology |
Neuroscience Letter |
Gut |
Pain |
Neuroscience |
Gastroenterology |
Journal of Neurophysiology |
Journal of Neuropharmacology |
Journal of Physiology |
NATIONAL ELECTED/APPOINTED LEADERSHIP AND COMMITTEE POSITIONS: |
05/2006 Chairperson of the session entitled-"Sensory and Motility Disorders of the Esophagus", Digestive Disease Week, Washington, DC |
2009 - 2012 Member, Review committee, American Gastroenterology Association |
2009 - 2010 Member, Review Committee, National Science Foundation |
2010 Member, NIH Review Committee of ZRG1 CFS (01), (Chronic Fatigue, Fibromyalgia and Temporomandibular Dysfunction Syndromes), NIH Special Emphasis Group |
2013 - 2014 Member, NIH Review Committee of ZRG1 HDM-Q (02), NIH Health Delivery Methodologies Special Emphasis Group |
2013 - 2014 Member, NIH Review Committee of ZRG1 DKUS-N (05), NIH Kidney & Urological Science Special Emphasis Group |
2014 - Present Member, NIH Study Section of Urogenital Physiology and Pathophysiology (UGPP) |
05/2017 Member, Member of NIH Study Section of NIDDK Review of P20 Developmental Centers for Interdisciplinary Research in Benign Urology (P20) |
06/2017 Review Meeting: NIGMS SCORE Neuroscience Review (ZGM1 RCB-5 (SC) |
04/2018 Review Meeting: ZRG1 IFCN-N (80): Somatosensory and Pain Systems [SPS], NINDS Somatosensory & Chemosensory Study Section |
07/2019 Review meeting: 201908 ZRG1 IFCN-N (55) S |
07/2019 Review meeting: 201908 ZRG1 ETTN-B (70) R_ SPARC/HEAL U01 FOA |
2019 - 2022 Review meeting: NIH UGPPP study section, ZRG1 DKUS-B (90) S |
03/2022 Review meeting: 202201 ZRG1 DKUS-W (05) M |
06/2022 Review meeting: 202201 ZDK1 GRB-M (03) P |
06/2023 Review meeting: P20 DK22-027 |
07/2023 Review meeting: ZDK1 GRB-Q (O1) R |
INTERNATIONAL ELECTED/APPOINTED LEADERSHIP AND COMMITTEE POSITIONS: |
09/05/2006 Avignon, France, 2nd plenary session entitled – “Recent advances in understanding the sensory function and dysfunction of the foregut”, World Organization of Special Studies on Disease for the Esophagus |
2011 Member, Ph.D. Committee, Department of Physiology, University of Melbourne, Australia |
2012 - 2013 Member, Review Committee, Wellcome Trust Research Foundation, UK |
RESEARCH GRANTS/AWARDS/CONTRACTS/PROJECTS: | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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INVITED LECTURES/WORKSHOPS/PRESENTATIONS: |
National |
Sengupta JN, An Overview of Esophageal Sensory Receptors, Second Multi-Disciplinary International Symposium of Supra-Esophageal Complications, Seattle, Washington DC, 07/1998 |
Sengupta JN, Electrophysiological Recording from the Neurons Controlling Sensory and Motor Functions of the Esophagus, Third Multi-Disciplinary International Symposium of Supra-Esophageal Complications, Boston, MA, 07/2000 |
Sengupta JN, Peripheral Mechanism of Visceral Pain: physiology and pharmacology, International Motility Meeting, Madison, WI, 10/2001 |
Sengupta JN, Effect of Intraesophageal Acid on Responses of Laryngeal Muscles and Motoneurons of the Cat, American Gastroenterology Association, New Orleans, LO, 05/2004 |
Sengupta JN, Esophageal Sensory Receptors: Vagal and Spinal Afferents, Multidisciplinary International Symposium on Supraesophageal Complication of Reflux Disease, Miami, FL, 02/2005 |
Sengupta JN, Role of Central Serotonergic System in Visceral Pain, Neurogastroenterology and Motility Meeting, St.Louis, MO, 09/2011 |
Sengupta JN, : Effect of the gastrointestinal environment on development and function of the central nervous system, Mead Johnson Nutrition, Inc., San Francisco, CA, 10/2012 |
Sengupta JN, Most Important Advances in Visceral Pain in the last Year, Digestive Disease Week, 2014/American Gastroenterology Association, USA, Chicago, IL, 05/2014 |
International |
Sengupta JN, Xin S and Gebhart GF, Polymodal Mechanosensitive Pelvic nerve afferent fibers innervating the colon of the rat, International Union of Physiological Society (IUPS), St. Petersburg, Russia, 08/1997 |
Sengupta JN and Gebhart GF, Role of Pelvic nerve afferent fibers in Visceral Pain, Little Brain Big Brain, Melbourne, Australia, 08/1998 |
Sengupta JN, Role of Pelvic nerve afferent fibers in Visceral Pain, Enteric Nervous System Symposium, Göteborg, Sweden, 09/1998 |
Sengupta JN, Neural Mechanism of Visceral Pain, Karolinska Institute, Stockholm, Sweden, 11/1998 |
Sengupta JN, Altered Visceral Sensation in Response to Somatic Pain in the Rat, Little Brain Big Brain, Barcelona, Spain, 09/2003 |
Sengupta JN, Early-life Events Leading to Visceral Hypersensitivity, Gastrointestinal Research Unit, Queen’s University, Queens, Canada, 09/2007 |
MEDICAL COLLEGE TEACHING ACTIVITIES: |
Medical Student Education |
2009 - 2013 Interdisciplinary Life Science Program |
2009 - Present Neuroanatomy Lab Teaching |
Graduate Student Education |
2010 - 2022 Neuroscience Doctoral Program |
BIBLIOGRAPHY |
Refereed Journal Publications/Original Papers |
1. Banerjee B, Medda BK, Zhang J, Tuchscherer V, Babygirija R, Kannampalli P, Sengupta JN, Shaker R. Prolonged esophageal acid exposures induce synaptic downscaling of cortical membrane AMPA receptor subunits in rats. Neurogastroenterol Motil. 2016 Sep;28(9):1356-69. PMCID: PMC5063079 |
2. Kannampalli P, Babygirija R, Zhang J, Poe MM, Li G, Cook JM, Shaker R, Banerjee B, Sengupta JN. Neonatal bladder inflammation induces long-term visceral pain and altered responses of spinal neurons in adult rats. Neuroscience. 2017 Mar 27;346:349-364. PMCID: PMC5337157 |
3. Babygirija R, Sood M, Kannampalli P, Sengupta JN, Miranda A. Percutaneous electrical nerve field stimulation modulates central pain pathways and attenuates post-inflammatory visceral and somatic hyperalgesia in rats. Neuroscience. 2017 Jul 25;356:11-21. |
4. Zhang J, Yu J, Kannampalli P, Nie L, Meng H, Medda BK, Shaker R, Sengupta JN, Banerjee B. MicroRNA-mediated downregulation of potassium-chloride-cotransporter and vesicular γ-aminobutyric acid transporter expression in spinal cord contributes to neonatal cystitis-induced visceral pain in rats. Pain. 2017 Dec;158(12):2461-2474. PMCID: PMC5680103 |
5. Kannampalli P, Poli SM, Boléa C, Sengupta JN. Analgesic effect of ADX71441, a positive allosteric modulator (PAM) of GABA<sub>B</sub> receptor in a rat model of bladder pain. Neuropharmacology. 2017 Nov;126:1-11. |
6. Sengupta JN, Pochiraju S, Kannampalli P, Bruckert M, Addya S, Yadav P, Miranda A, Shaker R, Banerjee B. Erratum: MicroRNA-mediated GABA <inf>Aα-1</inf> receptor subunit down-regulation in adult spinal cord following neonatal cystitis-induced chronic visceral pain in rats (Pain (2012) 154:1 (59-70)) Pain. March 2013;154(3):493. |
7. Sengupta JN, Shaker R. Vagal afferent nerve stimulated reflexes in the GI tract Advances in Vagal Afferent Neurobiology. 1 January 2005:379-401. |
8. Sengupta JN, Gebhart GF. The sensory innervation of the colon and its modulation Current Opinion in Gastroenterology. 1998;14(1):15-20. |
9. Goyal RK, Sengupta JN. Neurophysiology of chest pain European Journal of Gastroenterology and Hepatology. 1990;2(1):4-7. |
10. Terashvili M, Talluri B, Palangmonthip W, Iczkowski KA, Sanvanson P, Medda BK, Banerjee B, Cunningham CW, Sengupta JN. Peripheral antinociceptive effects of a bifunctional μ and δ opioid receptor ligand in rat model of inflammatory bladder pain. Neuropharmacology. 2021 Sep 15;196:108701. PMCID: PMC8435000 |
11. Talluri B, Hoelzel F, Medda BK, Terashvili M, Sanvanson P, Shaker R, Banerjee A, Sengupta JN, Banerjee B. Identification and characterization of rostral ventromedial medulla neurons synaptically connected to the urinary bladder afferents in female rats with or without neonatal cystitis. J Comp Neurol. 2022 Jun;530(8):1129-1147. PMCID: PMC8967775 |