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CURRICULUM VITAE

Jyoti N. Sengupta PhD
Professor
Department of Medicine
Division of Gastroenterology

OFFICE ADDRESS:
MACC Fund Research Center
8701 Watertown Plank Rd
Milwaukee, WI 53226

EDUCATION:
1973 - 1975 Bachelor of Science (BSc), Physiology, University of Calcutta, India
1976 - 1977 Master of Science (MSc), Physiology, University of Calcutta, India
1983 - 1985 Ph.D in Physiology, University of Calcutta, India

POSTGRADUATE TRAINING AND FELLOWSHIP APPOINTMENTS:
1985 - 1986 Postdoctoral Fellow, College of Pharmacy, Ohio State University, Columbus, OH
1986 - 1990 Research Associate, Gastroenterology, Harvard Medical School/Beth Israel Hospital, MA
1991 - 1997 Assistant Research Scientist, Pharmacology, University of Iowa, IA

FACULTY APPOINTMENTS:
1990 - 1991 Instructor, Medicine, Harvard Medical School/Beth Israel Hospital, MA
1998 - 2000 Associate Director, Gastroenterology, AstraZeneca, Molndal, Sweden
2000 - 2005 Assistant Professor, Medicine, Gastroenterology & Hepatology, Medical College of Wisconsin, Milwaukee, WI
2004 - 2014 Associate Professor (Secondary appointment), Pediatric Gastroenterology, Medical College of Wisconsin, Milwaukee, WI
2006 - 2014 Associate Professor, Medicine, Gastroenterology & Hepatology, Medical College of Wisconsin, Milwaukee, WI
2013 - Present Faculty, F1000, UK
2015 - Present Professor, Medicine, Gastroenterology & Hepatology, Medical College of Wisconsin, Milwaukee, WI
2015 - Present Professor, Pediatric Gastroenterology, Medical College of Wisconsin, Milwaukee, WI

ADMINISTRATIVE APPOINTMENTS:
2014 - 2019 Committee member of Institutional Animal Care & Use Committee, Medical College of Wisconsin, Milwaukee, WI

EDUCATIONAL ADMINISTRATIVE APPOINTMENTS:
2009 - Present Faculty Member of Neuroscience PhD Committee, Medical College of Wisconsin, Milwaukee, WI

AWARDS AND HONORS:
1977 - 1979 Junior Research Fellow, University Grants Commission of India
1980 - 1983 Senior Research Fellow, University Grants Commission of India
1985 Research Associate , University Grants Commission of India
2003 Recipient of Senior Basic Science Research Scientist Award, International Foundation of Functional Gastrointestinal Disorders (IFFGD)
2009 Recipient of 2009 Best Basic Science Research Scientist of Fucntional Brain-Gut Society

MEMBERSHIPS IN HONORARY AND PROFESSIONAL SOCIETIES:
1991 - Present International Association for Study of Pain (IASP)
1991 - Present Society for Neuroscience (SFN)
1998 - Present American Physiological Society (APS)
2001 - Present American Motility Society (AMS)
2017 - Present American Urology Association (AUA)

EDITORSHIPS/EDITORIAL BOARDS/JOURNAL REVIEWS:
Editorial Board
Editor, Special Topic Chapters: Visceral Pain: Recent Knowledge and Advancement, Frontiers Neuroscience
Associate Editor, Frontiers of Neuroscience
Journal Review
Journal of Neuroscience
Journal of Neurogastroenterology and Motility
Journal of Gastroenterology & Hepatology
Autonomic Neuroscience
Journal of Pain
American Journal of Physiology
Neuroscience Letter
Gut
Pain
Neuroscience
Gastroenterology
Journal of Neurophysiology
Journal of Neuropharmacology
Journal of Physiology

NATIONAL ELECTED/APPOINTED LEADERSHIP AND COMMITTEE POSITIONS:
05/2006 Chairperson of the session entitled-"Sensory and Motility Disorders of the Esophagus", Digestive Disease Week, Washington, DC
2009 - 2012 Member, Review committee, American Gastroenterology Association
2009 - 2010 Member, Review Committee, National Science Foundation
2010 Member, NIH Review Committee of ZRG1 CFS (01), (Chronic Fatigue, Fibromyalgia and Temporomandibular Dysfunction Syndromes), NIH Special Emphasis Group
2013 - 2014 Member, NIH Review Committee of ZRG1 HDM-Q (02), NIH Health Delivery Methodologies Special Emphasis Group
2013 - 2014 Member, NIH Review Committee of ZRG1 DKUS-N (05), NIH Kidney & Urological Science Special Emphasis Group
2014 - Present Member, NIH Study Section of Urogenital Physiology and Pathophysiology (UGPP)
05/2017 Member, Member of NIH Study Section of NIDDK Review of P20 Developmental Centers for Interdisciplinary Research in Benign Urology (P20)
06/2017 Review Meeting: NIGMS SCORE Neuroscience Review (ZGM1 RCB-5 (SC)
04/2018 Review Meeting: ZRG1 IFCN-N (80): Somatosensory and Pain Systems [SPS], NINDS Somatosensory & Chemosensory Study Section
07/2019 Review meeting: 201908 ZRG1 IFCN-N (55) S
07/2019 Review meeting: 201908 ZRG1 ETTN-B (70) R_ SPARC/HEAL U01 FOA
2019 - 2022 Review meeting: NIH UGPPP study section, ZRG1 DKUS-B (90) S
03/2022 Review meeting: 202201 ZRG1 DKUS-W (05) M
06/2022 Review meeting: 202201 ZDK1 GRB-M (03) P
06/2023 Review meeting: P20 DK22-027
07/2023 Review meeting: ZDK1 GRB-Q (O1) R

INTERNATIONAL ELECTED/APPOINTED LEADERSHIP AND COMMITTEE POSITIONS:
09/05/2006 Avignon, France, 2nd plenary session entitled – “Recent advances in understanding the sensory function and dysfunction of the foregut”, World Organization of Special Studies on Disease for the Esophagus
2011 Member, Ph.D. Committee, Department of Physiology, University of Melbourne, Australia
2012 - 2013 Member, Review Committee, Wellcome Trust Research Foundation, UK

RESEARCH GRANTS/AWARDS/CONTRACTS/PROJECTS:
Prior
Peer Review
Title:
Primary Visceral Afferents in Pain
Source:
NIH, 1 RO1 NS35790-01A1
Role:
Principal Investigator
Dates:
06/01/1997 - 03/31/2001
Direct Funds:
$450,000 (Per year)
  
Title:
Neurophysiological Basis of Visceral Hypersensitivity
Source:
MCW New Faculty Grant
Role:
Principal Investigator
Dates:
05/01/2001 - 04/01/2002
Direct Funds:
$12,500 (Per year)
  
Title:
Peripheral Mechanism of Esophageal Pain
Source:
MCW Digestive Disease Center
Role:
Principal Investigator
Dates:
08/01/2002 - 07/01/2003
Direct Funds:
$25,000 (Per year)
  
Title:
Mechanism of Esophageal Pain
Source:
NIH, 1 RO1 DK062312-01A2
Role:
Principal Investigator
Dates:
07/01/2004 - 06/30/2009
Direct Funds:
$150,000 (Per year)
  
Title:
Role of Viscero-visceral Convergence and Chronic Pelvic Pain
Source:
MCW Digestive Disease Center
Role:
Principal Investigator
Dates:
08/01/2005 - 06/30/2022
Direct Funds:
$20,000 (Per year)
  
Title:
Mechanism of Esophageal Pain, Supplemental of Minority Training Program
Source:
NIH, 1 RO1 DK062312-01A2
Role:
Principal Investigator and Mentor
Dates:
07/01/2006 - 06/30/2009
Direct Funds:
$90,000 (Per year)
  
Title:
Neural Plasticity and the Development of Overlapping Pelvic Pain
Source:
NIH, 1R56DK089493-01
Role:
Principal Investigator
Dates:
08/10/2010 - 06/30/2011
Direct Funds:
$373,927 (Per year)
  
Title:
Chronic Abdominal Pain and Central Modulation.
Source:
MCW Digestive Disease Center
Role:
Principal Investigator
Dates:
04/01/2012 - 03/30/2013
Direct Funds:
$20,000 (Per year)
  
Title:
Microglia-a New Target for Inflammation Induced Visceral Hyperalgesia
Source:
MCW Digestive Disease Center
Role:
Principal Investigator
Dates:
04/01/2012 - 03/30/2013
Direct Funds:
$25,000 (Per year)
  
Title:
Neurophysiological Basis of Neonatally-Induced Chronic Pelvic Pain
Source:
NIH, 1R01HD074604-01
Role:
Principal Investigator
Dates:
09/01/2012 - 08/31/2017
Direct Funds:
$350,000 (Per year)
  
Title:
Neuoromolecular Mechanisms of Chronic Pelvic Pain in Neonatally-Induced Cystitis
Source:
NIH, 1R01DK099201-01A1
Role:
Principal Investigator
Dates:
06/01/2014 - 05/31/2023
Direct Funds:
$279,032 (Per year)
  
Title:
Visceral Analgesic Effect of Probiotics
Source:
MCW Digestive Disease Center
Role:
Principal Investigator
Dates:
11/01/2014 - 10/31/2015
Direct Funds:
$20,000 (Per year)
  
Title:
Visceral Analgesic Effect of Positive Allosteric Modulators of GABAB Receptors in Inflammation-Induced Visceral Hyperalgesia in Rats
Source:
MCW Digestive Disease Center
Dates:
11/01/2016 - 10/03/2017
  
Title:
Effects of Mu/Delta Opioid Receptor Agonists for the Treatment of Pelvic Pain.
Source:
MCW Digestive Disease Center
Role:
Principal Investigator
Dates:
06/01/2018 - 05/30/2019
Direct Funds:
$20,000 (Per year)
  
Title:
Neuoromolecular Mechanisms of Chronic Pelvic Pain in Neonatally-Induced Cystitis
Source:
NIH, GRANT12515183
Role:
Principal Investigator
Dates:
07/01/2018 - 06/30/2023
Direct Funds:
$350,000 (Per year)
  
Title:
Effect of Angiotensin-(1-7)/Mas 1R Receptor for the Treatment of Pelvic Pain
Source:
MCW Digestive Disease Center
Role:
Principal Investigator
Dates:
11/01/2019 - 10/31/2020
Direct Funds:
$20,000 (Per year)
  
Non-Peer Review
Title:
Activation of Gastric Vagal Afferents
Source:
Impulse Dynamics, Haifa, Israel
Role:
Co-Investigator
Dates:
06/01/2001 - 05/31/2002
Direct Funds:
$100,000 (Per year)
  
Title:
Role of VR1/TRPV in Acid-Induced Sensitization of Vagal Afferent Fibers
Source:
AstraZeneca, Mölndal, Sweden
Role:
Principal Investigator
Dates:
06/01/2003 - 12/31/2004
Direct Funds:
$10,000
  
Title:
Mechanism of Action of 5HT4 Agonists in Visceral Pain and GI Motility
Source:
Procter & Gamble, Inc.
Role:
Principal Investigator
Dates:
08/01/2007 - 12/30/2009
Direct Funds:
$206,000 (Per year)
  
Title:
The Role of Microbiome in Chronic Visceral Hypersensitivity
Source:
Mead Johnson Nutrition, Inc.
Role:
Principal Investigator
Dates:
04/01/2012 - 03/30/2014
Direct Funds:
$20,000 (4 months)
  
Title:
Neural Mechanism of Cardiac Contractility Modulation of Left Ventricular Function
Source:
Impulse Dynamics, Inc.
Role:
Principal Investigator
Dates:
05/01/2014 - 01/31/2015
  
Title:
The Effect of GABAB Positive Allosteric Modulator ADX71441 in Visceral Pain
Source:
ADDEX Pharmaceutical Inc.
Role:
Principal Investigator
Dates:
04/01/2015 - 03/30/2016
Direct Funds:
$8,000 (Per year)
  

INVITED LECTURES/WORKSHOPS/PRESENTATIONS:
National
Sengupta JN, An Overview of Esophageal Sensory Receptors, Second Multi-Disciplinary International Symposium of Supra-Esophageal Complications, Seattle, Washington DC, 07/1998
Sengupta JN, Electrophysiological Recording from the Neurons Controlling Sensory and Motor Functions of the Esophagus, Third Multi-Disciplinary International Symposium of Supra-Esophageal Complications, Boston, MA, 07/2000
Sengupta JN, Peripheral Mechanism of Visceral Pain: physiology and pharmacology, International Motility Meeting, Madison, WI, 10/2001
Sengupta JN, Effect of Intraesophageal Acid on Responses of Laryngeal Muscles and Motoneurons of the Cat, American Gastroenterology Association, New Orleans, LO, 05/2004
Sengupta JN, Esophageal Sensory Receptors: Vagal and Spinal Afferents, Multidisciplinary International Symposium on Supraesophageal Complication of Reflux Disease, Miami, FL, 02/2005
Sengupta JN, Role of Central Serotonergic System in Visceral Pain, Neurogastroenterology and Motility Meeting, St.Louis, MO, 09/2011
Sengupta JN, : Effect of the gastrointestinal environment on development and function of the central nervous system, Mead Johnson Nutrition, Inc., San Francisco, CA, 10/2012
Sengupta JN, Most Important Advances in Visceral Pain in the last Year, Digestive Disease Week, 2014/American Gastroenterology Association, USA, Chicago, IL, 05/2014
 
International
Sengupta JN, Xin S and Gebhart GF, Polymodal Mechanosensitive Pelvic nerve afferent fibers innervating the colon of the rat, International Union of Physiological Society (IUPS), St. Petersburg, Russia, 08/1997
Sengupta JN and Gebhart GF, Role of Pelvic nerve afferent fibers in Visceral Pain, Little Brain Big Brain, Melbourne, Australia, 08/1998
Sengupta JN, Role of Pelvic nerve afferent fibers in Visceral Pain, Enteric Nervous System Symposium, Göteborg, Sweden, 09/1998
Sengupta JN, Neural Mechanism of Visceral Pain, Karolinska Institute, Stockholm, Sweden, 11/1998
Sengupta JN, Altered Visceral Sensation in Response to Somatic Pain in the Rat, Little Brain Big Brain, Barcelona, Spain, 09/2003
Sengupta JN, Early-life Events Leading to Visceral Hypersensitivity, Gastrointestinal Research Unit, Queen’s University, Queens, Canada, 09/2007
 

MEDICAL COLLEGE TEACHING ACTIVITIES:
Medical Student Education
2009 - 2013 Interdisciplinary Life Science Program
2009 - Present Neuroanatomy Lab Teaching
 
Graduate Student Education
2010 - 2022 Neuroscience Doctoral Program
 


BIBLIOGRAPHY
Refereed Journal Publications/Original Papers
1. Banerjee B, Medda BK, Zhang J, Tuchscherer V, Babygirija R, Kannampalli P, Sengupta JN, Shaker R. Prolonged esophageal acid exposures induce synaptic downscaling of cortical membrane AMPA receptor subunits in rats. Neurogastroenterol Motil. 2016 Sep;28(9):1356-69. PMCID: PMC5063079
2. Kannampalli P, Babygirija R, Zhang J, Poe MM, Li G, Cook JM, Shaker R, Banerjee B, Sengupta JN. Neonatal bladder inflammation induces long-term visceral pain and altered responses of spinal neurons in adult rats. Neuroscience. 2017 Mar 27;346:349-364. PMCID: PMC5337157
3. Babygirija R, Sood M, Kannampalli P, Sengupta JN, Miranda A. Percutaneous electrical nerve field stimulation modulates central pain pathways and attenuates post-inflammatory visceral and somatic hyperalgesia in rats. Neuroscience. 2017 Jul 25;356:11-21.
4. Zhang J, Yu J, Kannampalli P, Nie L, Meng H, Medda BK, Shaker R, Sengupta JN, Banerjee B. MicroRNA-mediated downregulation of potassium-chloride-cotransporter and vesicular γ-aminobutyric acid transporter expression in spinal cord contributes to neonatal cystitis-induced visceral pain in rats. Pain. 2017 Dec;158(12):2461-2474. PMCID: PMC5680103
5. Kannampalli P, Poli SM, Boléa C, Sengupta JN. Analgesic effect of ADX71441, a positive allosteric modulator (PAM) of GABA<sub>B</sub> receptor in a rat model of bladder pain. Neuropharmacology. 2017 Nov;126:1-11.
6. Sengupta JN, Pochiraju S, Kannampalli P, Bruckert M, Addya S, Yadav P, Miranda A, Shaker R, Banerjee B. Erratum: MicroRNA-mediated GABA <inf>Aα-1</inf> receptor subunit down-regulation in adult spinal cord following neonatal cystitis-induced chronic visceral pain in rats (Pain (2012) 154:1 (59-70)) Pain. March 2013;154(3):493.
7. Sengupta JN, Shaker R. Vagal afferent nerve stimulated reflexes in the GI tract Advances in Vagal Afferent Neurobiology. 1 January 2005:379-401.
8. Sengupta JN, Gebhart GF. The sensory innervation of the colon and its modulation Current Opinion in Gastroenterology. 1998;14(1):15-20.
9. Goyal RK, Sengupta JN. Neurophysiology of chest pain European Journal of Gastroenterology and Hepatology. 1990;2(1):4-7.
10. Terashvili M, Talluri B, Palangmonthip W, Iczkowski KA, Sanvanson P, Medda BK, Banerjee B, Cunningham CW, Sengupta JN. Peripheral antinociceptive effects of a bifunctional μ and δ opioid receptor ligand in rat model of inflammatory bladder pain. Neuropharmacology. 2021 Sep 15;196:108701. PMCID: PMC8435000
11. Talluri B, Hoelzel F, Medda BK, Terashvili M, Sanvanson P, Shaker R, Banerjee A, Sengupta JN, Banerjee B. Identification and characterization of rostral ventromedial medulla neurons synaptically connected to the urinary bladder afferents in female rats with or without neonatal cystitis. J Comp Neurol. 2022 Jun;530(8):1129-1147. PMCID: PMC8967775