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CURRICULUM VITAE

Kevin R. Regner MD
Interim Chief, Associate Professor
Department of Medicine
Division of Nephrology

OFFICE ADDRESS:
Health Research Center
8701 Watertown Plank Rd
Milwaukee, WI 53226

CITIZENSHIP:  USA

EDUCATION:
1993 - 1997 B.A. , Purdue University, West Lafayette, IN
1997 - 2001 M.D., Medical College of Wisconsin, Milwaukee, WI
2008 - 2011 M.S., Medical College of Wisconsin, Milwaukee, WI

POSTGRADUATE TRAINING AND FELLOWSHIP APPOINTMENTS:
2001 - 2004 Internal Medicine Residency, Mayo Clinic College of Medicine, Mayo Clinic, Rochester, MN
2004 - 2007 Nephrology Fellowship, Mayo Clinic College of Medicine, Mayo Clinic, Rochester, MN
2009 - 2011 Clinical Research Scholars Program (NIH funded K30), Medical College of Wisconsin, Milwaukee, WI

FACULTY APPOINTMENTS:
2006 - 2007 Instructor of Medicine, Mayo Clinic College of Medicine, Division of Nephrology, Mayo Clinic, Rochester, MN
2007 - Present Assistant Professor of Medicine , Department of Medicine, Division of Nephrology, Medical College of Wisconsin, Milwaukee, WI
2007 - Present Faculty member, Department of Medicine, Kidney Disease Center , Medical College of Wisconsin, Milwaukee, WI

HOSPITAL AND CLINICAL ADMINISTRATIVE APPOINTMENTS:
2007 - Present Froedtert Memorial Lutheran Hospital , Milwaukee, WI 53226

SPECIALTY BOARDS AND CERTIFICATION:
Board Certified
Issue DateExpiration
American Board ofInternal Medicine (ABIM)
2004
12/31/2014
ABIM – Nephrology
2007
12/31/2017
 
Licensure
Number Issue DateExpiration
State of Wisconsin
50061-020
1/24/2007
10/31/2009
 
AWARDS AND HONORS:
1997 - Present Phi Beta Kappa, Purdue University, West Lafayette, IN
2000 - Present Alpha Omega Alpha Medical Honor Society, Medical College of Wisconsin, Milwaukee, WI
2001 - Present William W. Engstrom Award in Internal Medicine, Medical College of Wisconsin, 2001.
2002 - Present Attitude, Commitment, and Excellence Award, Department of Medicine, Mayo Clinic Internal Medicine Residency
2004 - Present Attitude, Commitment, and Excellence Award, Department of Medicine, Mayo Clinic Internal Medicine Residency.
2004 - Present Outstanding Achievement Award, Department of Medicine, Mayo Clinic College of Medicine.
2007 - Present Outstanding Achievement Award, Division of Nephrology, Mayo Clinic College of Medicine.
2009 - Present Outstanding Medical Student Teacher Award Second year medical student Pathology course (renal section) Medical College of Wisconsin
2010 - Present Central Society for Clinical Research - 'K Award Grant' Central Society for Clinical Research & Midwestern Section of the American Federation for Medical Research Combined Annual Meeting, April 2010
2011 - Present Nominee, T. Michael Bolger Standing Ovation Award

MEMBERSHIPS IN HONORARY AND PROFESSIONAL SOCIETIES:
2008 - Present Central Society for Clinical Research (Member)
2009 - Present American Society of Nephrology (Fellow)
Member (Renal Physicians Association)
Member (National Kidney Foundation)
Member (American College of Physicians)
Member (International Society of Nephrology)

EDITORSHIPS/EDITORIAL BOARDS/JOURNAL REVIEWS:
Journal Review
2010 Clinical and Translational Science Institute of Southeast Wisconsin Grant Committee
International Journal of Urology
Mayo Clinic Proceedings
Journal of Hypertension
Annals of Transplantation
Journal of Urology
Hypertension
Nephron - Experimental Nephrology

LOCAL/REGIONAL APPOINTED LEADERSHIP AND COMMITTEE POSITIONS:
2008 - 2010 Central Line Committee Froedtert Memorial Lutheran Hospital
2008 - 2009 Advance Care Initiative Standard and Quality Improvement Workgroup Froedtert Memorial Lutheran Hospital
2008 - Present Specialty consultant for adult nephrology/dialysis Wisconsin Poison Center Milwaukee, WI
2008 - 2010 Intern Selection Committee Department of Internal Medicine Medical College of Wisconsin
2009 - 2010 National Kidney Foundation of Wisconsin Member, Wisconsin Chronic Kidney Disease Task Force
2009 - Present Nephrology Fellow Selection Committee Division of Nephrology Medical College of Wisconsin

RESEARCH GRANTS/AWARDS/CONTRACTS/PROJECTS:
Active
Peer Review
Title:
20-HETE mediated protection from ischemic renal injury
Source:
MCW-CTSI & Advancing a Healthier Wisconsin
Role:
PI
Dates:
7/1/2008 - 6/30/2011
 
Title:
Activator of G Protein Signaling 3 in Renal Ischemia-Reperfusion Injury
Source:
Medical College of Wisconsin Research Affairs Committee New Faculty Grant
Role:
PI
Dates:
7/1/2010 - 6/30/2011
 
Title:
Characterizing a Novel Model of Proteinuria Using Nr4al Nuclear Receptor Knockout Rats
Source:
NIH/NIDDK Integrative Biology of Childhood Kidney Disease
Role:
PI
 
Pending
Peer Review
Title:
Activator of G Protein Signaling 3 in Ischemic Renal Injury
Source:
NIH/NIDDK
Role:
PI
 
INVITED LECTURES/WORKSHOPS/PRESENTATIONS:
Local
1. "Role of 20-HETE in renal ischemia-reperfusion injury" Department of Physiology, Medical College of Wisconsin Milwaukee, WI , 7/14/2010 - Present
 
International
1. "Role of 20-HETE in renal ischemia-reperfusion injury" The 12th International Winter Eicosanoid Conference Baltimore, 3/10/2010 - Present
 
COMMITTEE SERVICE:
Medical College
2010 - Present Clinical and Translational Science Master’s Program Advisory Committee
2011 - Present Research Affairs Committee (Elected 2011)
 
MEDICAL COLLEGE TEACHING ACTIVITIES:
Medical Student Education
2007 - Present Attending Physician, Nephrology Inpatient or Consult Service (Third and fourth year medical students)
2008 - 2009 Preceptor, Clinical Examination & Reasoning (CER) Course (Second year medical students)
2009 - Present “Inherited and Cystic Diseases of the Kidney” Pathology Course - second year medical students
2009 - Present “Chronic Kidney Disease and Vascular Diseases of the Kidney” Pathology Course - second year medical students
2009 - Present “Tubulointerstitial Diseases of the Kidney” Pathology Course - second year medical students
2009 - Present “Review of Renal Pathology” Pathology Course - second year medical students
2009 - Present “Nephrolithiasis and Obstructive Diseases of the Kidney” Pathology Course - second year medical students
2010 - Present Mentor, Cultural Sensitivity Skills Program (Second year medical students)
2010 - Present “Nephrology” MKSAP 4 – third year medical students Internal medicine clerkship board review session
2011 - Present Small group facilitator, Physician Scientist Pathway (Second year medical students)
 
Resident and Fellow Education
2007 - 2009 “Basics of Kidney Disease: Glomerular, Interstitial, and Cystic Diseases of the Kidney” Nephrology lecture series for trainees on Nephrology rotation
2007 - Present Attending Physician, Inpatient Nephrology or Consult Service
2007 - Present Nephrology case conference facilitator Nephrology residents and fellows
2008 “Renal Replacement Therapy for Acute Kidney Injury” Pulmonary Critical Care Fellows Seminar
2009 - Present Continuity clinic preceptor Nephrology fellows’ outpatient clinic
2009 “Renal Amyloidosis” Clinical-Pathologic Conference Department of Medicine
2009 - Present “Continuous Renal Replacement Therapy for Acute Kidney Injury and Electrolyte Disorder” Critical Care Residents Seminar
2009 “Evaluation and management of electrolyte abnormalities in the acute care setting” Academic Half Day - Internal Medicine Residents
2/2/2010 “Urinary Exosomes in Polycystic Kidney Disease” Nephrology Research Conference
7/27/2010 “Role of Mitochondrial Autophagy in Aging Kidneys” Nephrology Journal Club
8/25/2010 “AKI and Renal Replacement Therapies in the ICU”Summer core curriculum for Intensive Care fellows again
11/30/2010 “Role of Klotho in Acute Kidney Injury” Nephrology Journal Club
2010 “Glomerular Diseases” Academic Half Day - Internal Medicine Residents
2010 “Continuous Renal Replacement Therapy” Nephrology Fellows’ Core Curriculum
 
Continuing Medical Education
9/4/2007 “Continuous Renal Replacement Therapy: Targeting Optimal Dose” Division of Nephrology Research Conference
11/9/2007 “Continuous Renal Replacement Therapy for Critical Care RNs” Critical Care Nurse Education
12/14/2007 “Diagnosis and management of dysnatremias in the acute care setting” Pulmonary & Critical Care division weekly conference
2/1/2008 “Renal replacement therapy for acute kidney injury: current controversies and future directions” Department of Medicine Grand Rounds
10/21/2008 “Protective effect of 20-HETE analogues in renal ischemia-reperfusion injury” Nephrology Research Conference
2008 “Acute Kidney Injury for Nephrology Nurses” Lecture series for Nephrology Nursing Staff
1/27/2009 “Endothelial to mesenchymal transition in renal fibrosis” Nephrology Research Conference
1/20/2010 “Acute kidney injury and cardiovascular disease” Cardiology Grand Rounds
2/16/2010 “Role of 20-HETE in renal ischemia-reperfusion injury” Nephrology Research Conference
2/18/2010 “Urinary exosomes: a source of biomarkers in polycystic kidney disease” Population Health Research Seminar
4/19/2010 “Experimental treatments for acute kidney injury” Cardiovascular Center Advisory Board Meeting
4/21/2010 “Role of 20-HETE in renal ischemia-reperfusion injury” Clinical Translational Science Institute
 
EXTRAMURAL TEACHING (e.g. at Marquette, UWM, etc.):
Medical Student Education
2009 - Present “Glomerular Diseases of the Kidney” Pathology Course - second year medical students
2011 “Acute Kidney Injury” Team based learning small group session First year medical students
 
MCW STUDENTS, FACULTY, RESIDENTS AND CLINICAL/RESEARCH FELLOWS MENTORED:
Medical Students
Brodie Marthaler, MCW, 1/2010 - Present Research mentor (T35 Training Grant from NHLBI)
 
Clinical/Research Fellows
Aaron Dall, MD, MCW, 10/2007 - 6/2008 Research advisor
Lakshmi Raman, MD, MCW, 4/2009 - 11/2009 Research advisor
Kumar Shrishramal, MD, MCW, 4/2011 - Present Research advisor
 
Residents
Ammar Haque, MD, MCW, 10/2007 - 6/2009 Research advisor
 
Faculty
Afzal Usman, MD, MCW, 8/2010 - Present Research mentor
 
PROGRAMMATIC DEVELOPMENTS:
Educational Programs
Student
2011 Developed critical care nephrology e-curriculum for nephrology fellowship program
Fellow
2007 Developed critical care nephrology e-curriculum for nephrology fellowship program
 
 
Clinical Programs
2007 - Present Developed multidisciplinary continuous renal replacement therapy working group
 
 
COMMUNITY SERVICE ACTIVITIES:
2009 Coordinated a National Kidney Foundation "Kidney Early Evaluation Program" in collaboration with the Wisconsin chapter of the NKF.
2010 Coordinated a National Kidney Foundation "Kidney Early Evaluation Program" in collaboration with the Wisconsin chapter of the NKF.


BIBLIOGRAPHY
Refereed Journal Publications/Original Papers
1. Cohen EP, Regner K, Fish BL, Moulder JE. Stenotic glomerulotubular necks in radiation nephropathy. J Pathol 2000;190:484-488.
2. Moulder JE, Fish BL, Regner KR, Cohen EP, Raife TJ. Retinoic acid exacerbates experimental radiation nephropathy. Radiat Res 2002;57:199-203.
3. Moulder JE, Fish BL, Regner KR, Cohen EP. Angiotensin II blockade reduces radiation-induced proliferation in experimental radiation nephropathy. Radiat Res 2002;157:393-401.
4. Ensminger SA, Regner KR, Froehling DA. 35-Year-Old Woman with fever, cough, and anorexia. Mayo Clin Proc 2003;78:753-756.
5. Regner, KR, Connolly, HM, Schaff, HV, Albright, RC. Acute renal failure after cardiac surgery for carcinoid heart disease: Incidence, risk factors, and prognosis. Am J Kid Dis 2005; 45:826-823.
6. Regner KR, Zuk A, Shames BD, Van Why SK, Ryan RP, Falck JR, Manthati VL, Roman RJ. Protective effect of 20-HETE analogues in experimental renal ischemia-reperfusion injury. Kidney Int. 2009 Mar;75(5):511-517.
7. Liang H, Hilton G, Regner KR, Johnson CP, Nilakantan V. MnTmPyP, a cell permeable SOD mimetic, reduces oxidative stress and apoptosis induced by renal ischemia-reperfusion injury in vivo. Am J Physiol Renal Physiol. 2009:296:F266-276.
8. Akbulut T, Regner KR, Roman RJ, Avner ED, Falck JR, Park F. 20-HETE activates the Raf/MEK/ERK pathway in the renal epithelial cells through EGFR- and c-Src-dependent mechanism. Am J Physiol Renal Physiol 2009; 297:F662-F670. PMID: 19570883
9. Solberg-Woods L, Stelloh C, Regner KR, Schwabe T, Eisenhauer J, Garrett MR. Heterogenous stock rats - a new animal model to study the genetics of renal injury. Am J Physiol Renal Physiol 2010; 298:F1484-91. PMID: 20219828
10. Ionova IA, Vasquez-Vivar J, Cooley BC, Khanna AK, Whitsett J, Herrnreiter A, Migrino RQ, Ge Z, Regner KR, Channon KM, Alp NJ, Pieper GM. Cardiac Myocyte-Specific Over-expression of Human GTP Cyclohydrolase I Protects Against Acute Cardiac Allograft Rejection. Am J Physiol Heart Circ Physiol. 2010; 299:H88-96. PMID: 20418482
11. Regner KR, Nilakantan V, Mortenson J, White SM, Ryan RP, Roman RJ. Protective Effect of Lifor Solution in Experimental Renal Ischemia-Reperfusion Injury. J Surg Research 2010;164:e291-297. PMID: 20888590.
12. Regner KR, Nozu K, Lanier SM, Blumer JB, Avner ED, Sweeney, Jr WE, Park F. Loss of Activator of G Protein Signaling 3 Impairs Renal Tubular Regeneration Following Acute Kidney Injury in Rodents. FASEB Journal 2011; PMID: 21343176
13. Regner KR, Williams J, Stelloh C, Lerch-Gaggl A, White S, Garrett M. A Model of Accelerated Chronic Kidney Disease by Genetic Modification of the Dahl Salt-Sensitive Rat. Submitted to Am J Physiol - Renal Physiol.
14. Regner KR, Marthaler B, Van Why SK, Ryan RP, Falck JR, Garrett MR, Roman RJ. Increased Renal CYP4A Expression and 20-HETE Production Promotes Resistance to Renal Ischemia-Reperfusion Injury in Rats. Manuscript in preparation.
15. Regner KR, Williams JM, Eisenhauer J, Stelloh C, Mattson DL, Garrett MR. Knockout of Nuclear Receptor 4a1 on a Hypertensive Genetic Background Results in Severe Renal Injury. Manuscript in preparation.
16. Akbulut T, Nilakantan V, Falck JR, Roman RJ, Park F, Regner KR. 20-HETE analogues increase renal proximal tubular cell survival and decrease apoptosis following experimental ischemia-reperfusion injury. Manuscript in preparation.
17. Herrmann D, Saleh M, Regner KR. Phenytoin monitoring and dose adjustment during continuous veno-venous hemofiltration. Manuscript in preparation.
 
Books, Chapters, and Reviews
1. Regner KR. Epidemiology of acute kidney injury after cardiac surgery: an update. Journal of Organ Dysfunction 2007;3(4):232-239. *Invited review.
2. Ratkalkar V and Regner KR. Approach to the Patient with Hematuria, In: Clinical Decision Making in Nephrology, Hypertension, and Renal Transplantation: A Problem-Solving Approach. E Lerma and M Rosner Eds. Springer. Submitted.
3. Regner KR and Roman RJ. Role of renal medullary hemodynamic in ischemia-reperfusion injury. Curr Opin Nephrol Hypertens. In prepration. *Invited review.
 
Editorials, Letters to Editor, Other
1. Regner KR, Riegert-Johnson DL, Volcheck GW. Serial Measurement of Serum Tryptase Levels in Angiotensin Converting Enzyme Inhibitor Associated Angioedema. Mayo Clin Proc 2003; 78:655-656. PMID: 12744557.
2. El-Zoghby ZM, Regner KR, Regner DM, Haugen EN. Obstructive Renal Failure from Malpositioned Urinary Catheter. Kidney Int 2008; 73:1330. PMID: 18480860.
3. Roman RJ, Akbulut T, Park F, Regner KR. 20-HETE in Acute Kidney Injury. Kidney Int. 2011;79:10-13. PMID: 21157458.
 
Abstracts
1. Moulder JE, Fish BL, Regner KR, Cohen EP, Raife TJ. The growth promoter All-trans retinoic acid (ATRA) exacerbates experimental radiation nephropathy. Presented at the Forty-seventh Annual Meeting of the Radiation Research Society, April 29-May 3, 2000; Albuquerque, New Mexico, USA.
2. Regner, KR, Connolly, HM, Schaff, HV, Albright, RC. Acute renal failure after cardiac surgery for carcinoid heart disease: Incidence, risk factors, and prognosis. Presented at the 36th Annual Meeting & Scientific Exposition of the American Society of Nephrology, November 14-17, 2003; San Diego, California, USA.
3. Regner, KR, McGoon, MD, Frantz, RP, Haugen, EN. Chronic kidney disease is associated with pulmonary hypertension and right heart dysfunction. Presented at the National Kidney Foundation Clinical Meeting, April 19-23, 2006; Chicago, IL, USA.
4. Regner, KR, Grande, JP, Roberts, L, Platt, JL, Haugen, EN. Digestion of heparan sulfate from renal tubular epithelium in human acute tubular necrosis. Presented at the American Society of Nephrology annual meeting, November 15-19, 2006; San Diego, CA, USA.
5. Dall A, Regner KR, Hussain S. Outcome of severe acute renal failure - a Veterans Affairs Study. Presented at the 13th International Conference on Continuous Renal Replacement Therapies. February 27- March 1, 2008; San Diego, CA, USA
6. El-Zoghby, Z, Regner KR, Keegan, M, Casey, E. Factitious hyperphosphatemia due to sample contamination with heparin in an arterial line. Presented at the National Kidney Foundation Clinical Meeting, April 2-6, 2008; Dallas, TX, USA.
7. Haque A, Dall A, Hussain S, Regner, KR. Survival of elderly patients with acute kidney injury requiring continuous renal replacement therapy. Presented at the National Kidney Foundation 2008 Spring Clinical Meeting, April 2-6, 2008, Dallas, Texas, USA.
8. Regner KR, Zuk A, Shames BD, Van Why SK, Falck JR, Roman RJ. The 20-HETE analogue, N-[20-hydroxyeicosa-5(Z),14(Z)-dienoyl]glycine, mitigates experimental renal ischemia-reperfusion injury and prevents the post-ischemic fall in medullary blood flow. J Am Soc Nephrol 2008; 19:400A.
9. Haque A, Dall A, Marwaha A, Hussain S, Regner KR. Patient survival and renal outcomes in elderly patients with acute kidney injury requiring continuous renal replacement therapy. J Am Soc Nephrol 2008; 19:797A.
10. Deshmukh A, Kleinman J, Blumenthal S, Regner KR, Hussain S. Treatment of Membranous Nephropathy with Rituximab. J Am Soc Nephrol 2008; 19:970A.
11. Marwaha A, Regner KR, Dall A, Haque A, Piering W, Hussain S. Epidemiology and Demographics of Biopsy-Proven Acute Interstitial Nephritis. J Am Soc Nephrol 2008; 19:988A.
12. Akbulut T, Regner KR, Roman RJ, Park F. Effects of 20-HETE analogues on intracellular signaling cascades in renal proximal tubular cells. FASEB J. 2009 23:816.5.
13. Akbulut T, Roman RJ, Park F, Regner KR. Effect of 20-HETE analogues on renal proximal tubular cell survival following experimental ischemia-reperfusion injury. J Am Soc Nephrol 2009; 20:323A.
14. Regner KR, Nilakantan V, Mortenson J, White SM, Roman RJ. Lifor preservation solution mitigates experimental renal-ischemia reperfusion injury. J Am Soc Nephrol 2009; 20:337A.
15. Regner KR, Stelloh C, Eisenhauer J, Lenz MA, Garrett MR. An accelerated model of chronic kidney disease by genetic modification of the Dahl salt-sensitive rat. J Am Soc Nephrol 2009; 20:68A.
16. Raman L, Regner KR, Blumenthal S. Long Term Follow Up of Loss of Renal Function after an Episode of Acute Kidney Injury. J Am Soc Nephrol 2009; 20:114A.
17. Solberg-Woods L, Stelloh C, Regner KR, Schwabe T, Eisenhauer J, Garrett MR. Heterogenous stock rats - a new animal model to study the genetics of renal injury. Presented at the 7th Annual Meeting on Rat Genomics & Models. Cold Spring Harbor, New York, 2009.
18. Saleh M, Herrmann D, Regner KR. Importance of phenytoin monitoring and dose adjustment while on Continuous Veno-Venous Hemofiltration. Continuous Renal Replacement Therapy 2010 meeting, San Diego, CA, USA, Feb 2010.
19. Regner KR, Akbulut T, Park F, Roman RJ. 20-HETE mitigates experimental ischemia-reperfusion injury. J Invest Med 2010;58:670.
20. Marthaler B, White SM, Van Why SK, Garrett MR, Roman RJ, Regner KR. Increased Renal CYP4A Expression and 20-HETE Production Promotes Resistance to Renal Ischemia-reperfusion Injury in Rats. Presented at the American Society of Nephrology Meeting 2010.
21. Kampa N, Solberg-Woods L, Regner KR, Stelloh C, Garrett MR. A Novel Rat Model with >75% of Offspring Exhibiting Spontaneous Unilateral Renal Agenesis. Presented at the American Society of Nephrology Meeting 2010.
22. Regner KR, Kwon M, White S, Jia G, Nilakantan V, Park F. Activator of G protein signaling 3 promotes renal epithelial cell proliferation following ischemia-reperfusion injury. Presented at the American Society of Nephrology Meeting 2010.
23. Regner KR, Eisenhauer J, Stelloh C, Mattson DL, Cowley Jr AW, Garrett MR. Knockout of Nuclear Receptor 4a1 on a Hypertensive Genetic Background Results in Severe Renal Injury. Presented at the American Society of Nephrology Meeting 2010.
24. Williams JM, Stelloh C, Regner KR, Roman RJ, Garrett MR. Genetic Variants in Arhgef11 linked to Proteinuria, Renal Hemodynamic Parameters and GFR in the Dahl Salt-Sensitive Rat. Presented at the American Society of Nephrology Meeting 2010.