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CURRICULUM VITAE

Marcelo Bonini PhD
Professor
Department of Medicine
Division of Endocrinology

HOME ADDRESS:
1509 North Jackson St
Unit P1
Milwaukee, WI 53202
Phone: 312-919-3872
 
OFFICE ADDRESS:
Health Research Center
8701 Watertown Plank Rd
Milwaukee, WI 53226

EDUCATION:
02/1995 - 12/1998 B.Sc., University of Sao Paulo, Sao Paulo, Brazil
02/1999 - 02/2004 Ph.D., University of Sao Paulo, Sao Paulo, Brazil

POSTGRADUATE TRAINING AND FELLOWSHIP APPOINTMENTS:
02/28/1999 - 02/28/2004 Ph.D., Biochemistry, University of Sao Paulo, Av. Prof Lineu Prestes 748, Cidade Universitaria, Sao Paulo
06/1999 - 12/2001 Teaching Assistant, Department of Biochemistry, Institute of Chemistry, University of Sao Paulo, Av. Prof Linea Prestes 748, Cidade Universitaria, Sao Paulo
05/11/2004 - 09/15/2009 Postdoctoral Fellow, National Institute of Environmental Health Sciences, NIEHS, NIH, 111 T.W. Alexander Road, Research Triangle Park, 27709

FACULTY APPOINTMENTS:
09/2009 - 02/2018 Assistant Professor, Departments of Medicine, Pathology and Pharmacology, College of Medicine, University of Illinois at Chicago, 840 S. Wood St 920S, Chicago, IL 60612
07/2015 - 02/2018 Associate Professor (tenured), Department of Medicine, University of Illinois at Chicago, 840 S. Wood St 920S, Chicago, IL 60612
02/2018 - Present Associate Professor, Department of Medicne, Division of Endocrinology, The Medical College of Wisconsin, 8701 Watertown Plank Rd, Milwaukee, WI 53226

ADMINISTRATIVE APPOINTMENTS:
09/2009 - 02/2018 Director Oxidative Stress Core Facility, Department of Medicine, University of Illinois at Chicago, 840 S. Wood St. 920S, Chicago, IL 60612
10/2015 - 10/2016 Associate Vice Chair for Research, Department of Medicine, University of Illinois at Chicago, 840 S. Wood St., 10th floor, Chicago, IL 60612.
01/2017 - 02/2018 Director (Redox Biology Program), Department of Medicine, University of Illinois at Chicago, 840 S. Wood St 920S, Chicago, IL 60612
02/2018 - Present Founding Director, Innate Immunity Program, Department of Medicine, The Medical College of Wisconsin,, 8701 Watertown Plank Rd, Milwaukee, WI 53226

EDUCATIONAL ADMINISTRATIVE APPOINTMENTS:
09/2015 - 02/2018 Director, Redox Biology Program, College of Medicine, University of Illinois at Chicago, 840 S. Wood, St., Chicago, IL 60612
02/2018 - Present Founding Director, Innate Immunity Program, Department of Medicine, The Medical College of Wisconsin,, 8701 Watertown Plank Rd, Milwaukee, WI 53226

HOSPITAL AND CLINICAL ADMINISTRATIVE APPOINTMENTS:
N/A

HOSPITAL STAFF PRIVILEGES:
N/A

AWARDS AND HONORS:
1999 - 2004 FAPESP Postgraduate Scholar, Sao Paulo, SP, Brazil.
2001 - Present Society for Free Radical Biology and Medicine "Young Investigator Award" recipient.
2002 - Present 7th International Symposium on Spin Trapping Travel Award recipient.
2003 - Present Chemistry Institute/University of Sao Paulo "Young Investigator Award" recipient.
2003 - Present Society for Free Radical Biology and Medicine "Young Investigator Award" recipient.
2003 - Present Young Talent in Life Sciences Award recipient (Amersham-Pharmacia).
2005 - Present Society for Free Radical Biology and Medicine "Young Investigator Award" recipient.
2007 - Present Fellowship Award for Research Excellence (FARE) - National Institutes of Health (NIH).
2007 - Present International Union of Biochemistry and Molecular Biology Young Scientist Award recipient.
2007 - Present Society for Free Radical Biology and Medicine "Young Investigator Award" recipient.
2009 - Present Author, NIEHS Intramural Paper of the Year, 2008
2012 - Present SFRBM - travel award/YIA to Kristine Ansenberger-Fricano.
2012 - Present Constance Campbell memorial award from the Illinois symposium on reproductive sciences
2013 - Present Young Investigator Award/Travel Award to Peter Hart, Society for Free Radical Biology and Medicine.
2014 - Present Faculty of the Year (Rising Star) College of Medicine, University of Illinois at Chicago. Office of the Dean for Faculty Affairs/COM.
03/11/2015 - Present Faculty of the Year, College of Medicine - UIC
06/2016 - Present Standing Member, SIEE - NIH/CSR
02/16/2017 - Present Scholar/Researcher of the Year, University of Illinois at Chicago
2017 - Present Faculty of the Year (Rising Star/Life Sciences) University of Illinois at Chicago. Office of the Vice Chancellor for Research.

MEMBERSHIPS IN HONORARY AND PROFESSIONAL SOCIETIES:
11/1998 - Present Society for Redox Biology (Member / Council Member)
11/1999 - Present Society for Redox Biology (USA)
01/2010 - Present American Heart Association (AHA)
09/2014 - Present American Society of Biochemistry and Molecular Biology (ASBMB)
04/2016 - Present ASBMB (Member)

EDITORSHIPS/EDITORIAL BOARDS/JOURNAL REVIEWS:
Editorial Board
2009 - Present Academic Editor PLoS One
2011 - Present Academic Editor, Frontiers Oxidant Physiology
2011 - Present Member, Free Radical Biology and Medicine
2012 - Present Member, Genes and Diseases

NATIONAL ELECTED/APPOINTED LEADERSHIP AND COMMITTEE POSITIONS:
2010 - Present Reviewer, University of Nebraska-Lincoln, Institute of Agriculture and Natural Resources (IANR) Strategic Investments Competitive Grants Program, Lincoln, NE
2011 - Present Ad. Hoc Reviewer, Department of Defense Army Research Office (DOD/ARO), Res. Tri. Pk, NC.
2012 - 2015 Member, Molecular Signaling 1 & 2, American Heart Association, Dallas, TX
2012 - Present Reviewer, North Carolina Biotechnology Center - Biotechnology Research Grant Program, Durham, NC
2012 - Present Member, Special Emphasis Panel (Super Fund), National Institute of Environmental Health Sciences, NIH, Res. Tri. Pk., NC (ZES1 LWJ-D (SF)).
10/2013 - 02/2016 Ad Hoc Reviewer, NIH Study Section, Systemic Injury by Environmental Exposures
2013 - Present Member, Program Committee, SRBM Annual Meeting, Society for Redox Biology and Medicine
2013 - 2015 Reviewer, Louisiana Board of Regents, Competitive Seed Grants, Baton Rouge, LA
2013 - 2016 Council Member, Society for Redox Biology and Medicine (SFRBM), Indianapolis, IN
2013 - Present Chair, SFRBM 20th Annual Meeting Plenary Session. "Mitochondria driven mechanisms of redox signaling in disease", Society for Redox Biology and Medicine
12/2014 - Present Ad Hoc Reviewer, NIH, "Innovative Approaches for the Identification of Mitochondria-Cell Signaling networks in response to environmental stress" RFA, Special Emphasis Panel.
2014 - Present Member, Program Committee, SFRBM Annual Meeting, Society for Redox Biology and Medicine
2015 - Present Reviewer, P30 Harvard University, Environmental Health Center Grant, Cambridge, MA
06/2016 - Present Member, NIH Study Section, Systemic Injury by Environmental Exposures
2016 - Present Chair, Organizing Committee, Inaugural Summer Symposium of the SFRBM, Society for Redox Biology and Medicine
02/2017 - Present Ad hoc Reviewer, NIH, "Pre-conception exposure windows and the health of the offspring" RFA, Special Emphasis Panel.
10/2017 - Present Ad hoc Reviewer, NIH/NSF, "Centers for Oceans and Human Health 3: Impacts of Climate Change on Oceans and the Great Lakes (COHH3): PO1". Special Emphasis Panel
02/2018 - Present Ad Hoc Reviewer, American Heart Association, Fellowships, Molecular and Cellular Signaling-1 Committee.

INTERNATIONAL ELECTED/APPOINTED LEADERSHIP AND COMMITTEE POSITIONS:
2013 - Present Member, College of Scientific Reviewers, Fundacao Araucaria Grant Proposal Reviewer, Curitiba, PR, Brazil
2014 - Present Member, College of Scientific Reviewers, Agencia Nacional de Investigacion y Innovacion, ANII, Montevideo, Uruguay
2016 - Present Ad Hoc Reviewer, National Research, Development and Innovation Office (NKFIH), Budapest, Hungary

RESEARCH GRANTS/AWARDS/CONTRACTS/PROJECTS:
Active
Peer Review
Title:
Signal transduction via the PI3k/Akt/PTEN pathways underlies the development of nitroglycerin tolerance.
Source:
American Heart Association
Role:
Principal-Investigator
PI:
Dr. Marcelo G. Bonini
Dates:
01/01/10 - 12/31/13
Direct Funds:
$308,000 (total amount)
 
Title:
Transcellular Mechanisms of Endothelial Permeability and Pulmonary Edema
Source:
NHLBI/NIH
Role:
Co-Investigator
PI:
Dr. Asrar B. Malik
Dates:
03/01/11 - 02/28/15
Direct Funds:
$236,620 (per annum)
 
Title:
Src Regulation of Endothelial Function
Source:
NHLBI/NIH
Role:
Co-Investigator
PI:
Dr. Richard D. Minshall
Dates:
03/01/11 - 02/28/15
Direct Funds:
$334,734 (per annum)
 
Title:
Electron Paramagnetic Resonance Spectrometer Shared Instrumentation Grant.
Source:
NCRR/NIH
Role:
Program Director
PI:
Dr. Marcelo G. Bonini
Dates:
04/02/11 - 03/31/12
Direct Funds:
$251,030 (total amount)
 
Title:
Defining mechanisms underlying listeria monocytogenes cardiac infections.
Source:
NIAID/NIH
Role:
Co-Investigator
PI:
Dr. Nancy Freitag
Dates:
01/01/12 - 12/31/13
Direct Funds:
$434,875 (total amount)
 
Title:
Role of Manganese Superoxide Dismutase (MnSOD) Peroxidase Activity in Cellular Resistance Against Apoptosis.
Source:
U.S. Department of Defense
Role:
Principal-Investigator
PI:
Dr. Marcelo G. Bonini
Dates:
07/01/12 - 02/28/16
Direct Funds:
$622,050 (total amount)
 
Title:
Listeria Virulence Gene Expressions Within Host Cells
Source:
NIAID/NIH
Role:
Co-Investigator
PI:
Dr. Nancy Freitag
Dates:
08/16/12 - 07/31/13
Direct Funds:
$63,800 (total/Bonini)
 
Title:
Mechanisms Of Nitroglycerin Induced Vascular Toxicity and Tolerance .
Source:
American Heart Association
Role:
Principal-Investigator
PI:
Dr. Marcelo G. Bonini
Dates:
07/01/13 - 06/30/15
Direct Funds:
$132,000 (total amount)
 
Title:
Modulation Of Vascular Extracellular Superoxide Dismutase
Source:
NHLBI/NIH
Role:
Co-Investigator
PI:
Dr. Tohru Fukai
Dates:
09/01/13 - 08/31/18
Direct Funds:
$1,897,004 (total amount)
 
Title:
New strategies for treating septic vasculopathy, inflammation and thrombosis
Source:
NHLBI/NIH
Role:
Co-Principal-Investigator
PI:
Dr. Xiaoping Du
Dates:
09/01/14 - 08/31/19
Direct Funds:
$3,979,525 (total amount)
 
Title:
Antioxidant enzymes and prostate cancer
Source:
NCI/NIH
Role:
Co-Investigator
PI:
Dr. Alan Diamond
Dates:
01/01/15 - 12/31/16
Direct Funds:
$548,277 (total amount)
 
Title:
The role of MnSOD allelic variations in prostate etiology and outcome
Source:
NCI/NIH
Role:
Co-Investigator
PI:
Dr. Alan Diamond
Dates:
03/01/15 - 02/28/19
Direct Funds:
$2,047,291 (total amount)
 
Title:
Novel Pharmacologic approaches to treat pulmonary arterial hypertension
Source:
U.S. Department Defense
Role:
Principal Investigator
PI:
Dr. Marcelo G. Bonini (Co-PI, Dr. Richard D. Minshall)
Dates:
03/01/15 - 02/28/19
Direct Funds:
$597,315 (total amount)
 
Title:
EGN-M01, a novel mitochondrial-targeting compound for the treatment of chemoresistant tumors
Source:
ILVentures
Role:
Principal Investigator
PI:
Dr. Marcelo G. Bonini
Dates:
03/15/17 - 10/14/17
Direct Funds:
$35,000 (total amount)
 
Title:
Macrophage redox state in sterilizing and injurious inflammation
Source:
NIAID/NIH
Role:
Principal Investigator
PI:
Dr. Marcelo G. Bonini
Dates:
04/01/17 - 03/31/22
Direct Funds:
$2,346,139 (total amount)
 
Title:
Environmental Arsenic Exposure and Breast Cancer Subtype Specification.
Source:
NIEHS/NIH
Role:
Principal Investigator
PI:
Dr. Marcelo G. Bonini
Dates:
09/07/17 - 08/31/18
Direct Funds:
$115,000 (total amount)
 
Title:
Vascular inflammation and loss of endothelial cell Cav-1 expression in insulin resistance
Source:
Dept. of Medicine Competitive Awards Program
Role:
Principal Investigator
PI:
Marcelo G. Bonini, PhD
Dates:
01/01/2015 - 12/31/2016
Direct Funds:
$50,000 (Total Funds)
 
Title:
Antioxidant enzyme polymorphisms and breast cancer risk.
Source:
University Illinois at Chicago Cancer Center
Role:
Co-Investigator
PI:
Marcelo G. Bonini, PhD, Dr. Alan Diamond
Dates:
09/16/2015 - 10/15/2016
Direct Funds:
$50,000 (Total Funds)
 
Non-Peer Review
Title:
Start up funds
Source:
University of Illinois College of Medicine
Role:
Principal Investigator
Dates:
09/15/2009 - 08/31/2016
Direct Funds:
$750,000 (total funds)
 
Title:
Start up funds
Source:
Advance Health Wisconsin/MCW Cancer Center
Role:
Principal Investigator
Dates:
02/01/2018 - 01/31/23
Direct Funds:
$2,400,000 (total funds)
 
Pending
Peer Review
Title:
MnSOD Acetylation Promotes Cancer Stem Cell Phenotypes in Breast Cancer
Source:
NIH/NCI
Role:
Principle Investigator
PI:
Marcelo G. Bonini, PhD
Dates:
04/01/2017 - 03/31/2022
Direct Funds:
$267,388 (Total Funds)
 
Title:
Targeting the Oncometabolism with Mitochondria-directed Chemicals
Source:
U.S. Department of Defense
Role:
Principal-Investigator
PI:
Dr. Marcelo G. Bonini
Dates:
10/01/2017 - 09/30/2020
Direct Funds:
$140,000 (total amount)
 
Source:
NCI/NIH
Role:
Principal Investigator
Dates:
04/01/2018 - 03/31/2023
Direct Funds:
$2,364,555 (total funds)
 
Title:
Environmental Arsenic Exposure and breast cancer subtype specification
Source:
NIEHS/NIH
Role:
Principal Investigator
PI:
Marcelo G. Bonini
Dates:
04/01/2018 - 03/31/2023
Direct Funds:
$2,562,978 (total funds)
 

INVITED LECTURES/WORKSHOPS/PRESENTATIONS:
Local
Bonini, M.G., Seeing is believing: Immunospin-trapping based imaging of protein free radical production in sub-cellular structures, Department of Biophysics, Medical College of Wisconsin, Milwaukee, WI, 2006
Bonini, M.G., Nitroglycerin-dependent vasodilation is mediated through signal transduction pathways, Department of Biophysics, Medical College of Wisconsin, Milwaukee, WI, 2009
Bonini, M.G., Inflammation by Design: Can nuclear transcriptional switches be regulated?, Department of Medicine, Medical College of Wisconsin, Milwaukee, WI, 01/30/2017
Bonini, M.G., Mitochondrial ROS and Cancer: Shedding Light onto the missing links, Department of Biophysics, Medical College of Wisconsin, Milwaukee, WI, 01/31/2017
 
Regional
Bonini, M.G., Constitutive nitric oxide synthase activation as an important route for nitroglycerin-induced vasorelaxation, Section of Cardiology, Cardiology Grand Rounds, University of Illinois at Chicago, Chicago, IL, 2008
Bonini, M.G., Constitutive nitric oxide synthase activation as an important route for nitroglycerin-induced vasorelaxation, Department of Pharmacology, University of Illinois at Chicago, Chicago, IL, 2008
Bonini, M.G., Endothelial nitric oxide (dys)function at the crossroads of nitroglycerin biologic activities, Department of Medicinal Chemistry and Pharmacognosy, University of Illinois at Chicago, Chicago, IL, 04/22/2011
Bonini, M.G., Manganese superoxide dismutase peroxidase activity sustains tumor resistance against apoptosis, Department of Biomedical Engineering, College of Medicine at Rockford, University of Illinois, Rockford, IL, 04/25/2011
Bonini, M.G., Nitroglycerin-induced loss of caveolin-1 results in endothelial nitric oxide dysfunction and vascular irresponsiveness to vasodilators, Department of Medicine, University of Illinois at Chicago, Chicago, IL, 12/03/2011
Bonini, M.G., Mitochondrial mechanisms of AMP-activated kinase (AMPK) activation in cancer, Department of Physiology and Biophysics, MSTP program invited speaker, University of Illinois at Chicago, Chicago, IL, 03/27/2012
Bonini, M.G., Mitochondrial ROS and Cancer: Shedding Light onto the missing links, , Inaugural Symposium of Redox Biology, Society for Redox Biology, University of Illinois at Chicago, IL, 06/10/2016
Bonini, M.G., Inflammation by design: Can nuclear transcriptional switches be redox regulated?, Department of Medicine, Division of Cardiovascular Sciences, Pritzker School of Medicine, University of Chicago, Chicago, IL, 09/15/2017
Bonini, M.G., SOD2 acetylation: a novel mitochondrial pathway for stemness reprogramming in cancer, Department of Biomedical Sciences, University of Illinois College of Medicine at Rockford, Rockford, IL, 03/14/2018
 
National
Bonini, M.G., The mechanism by which 2,2,6,6-tetramethyl-1-piperinyloxyl radical (tempol) diverts peroxynitrite reactivity from nitration to nitrosation reactions, 7th International Symposium on spin trapping, Research Triangle Park, NC, 2002
Bonini, M.G., Catalase inactivation by HOCl - immunospin trapping reveals protein radical formation in test tubes and cells, 8th International Symposium on Spin Trapping, Columbus, OH, 2005
Bonini, M.G., Nitric oxide synthase activation as new pathway for nitroglycerin-induced vasorelaxation, National Institute of Environmental Health Sciences, Science Awards Day 2007, Research Triangle Park, NC, 2007
Bonini, M.G., Constitutive nitric oxide synthase activation as an important route for nitroglycerin-induced vasorelaxation, Department of Pharmacology and Physiology, University of Medicine and Dentistry of New Jersey, Newark, NJ, 2008
Bonini, M.G., "The radical nature of detecting free radicals and biological oxidants", Invited Lecturer, Nicholas School of the Environment and Earth Sciences, Duke University, Durham, NC, 2008
Bonini, M.G., Linking oxidative chemistry to pathophysiology through the identification cellular redox switches, Department of Biochemistry and Biophysics, University of North Carolina, at Chapel Hill, Chapel Hill, NC, 2008
Bonini, M.G., MnSOD peroxidase activity as a novel mitochondrial redox regulator, EPR 2010, (14 th in vivo ESR/EPR spectroscopy & imaging and 11th international symposium on spin trapping/spin labeling), San Juan, Puerto Rico, 05/02/2010 - 05/06/2010
Bonini, M.G., Careers in Science Panel - Invited Speaker, Laboratory of Toxicology and Pharmacology Retreat, National Institute of Environmental Health Sciences (NIEHS/NIH), Research Triangle Park, NC, 02/14/2011
Bonini, M.G., Enzymatic functions defined by tracking redox reactions: the example of MnSOD, Society of Toxicology 51st annual meeting, San Francisco, CA, 03/14/2012
Bonini, M.G., Mitochondrial mechanisms of AMPK activation, American Society of Biochemistry and Molecular Biology (ASMBM) – Mitochondria energy signals and homeostasis symposium, East Lansing, MI, 06/27/2012
Bonini, M.G., Mitochondrial mechanisms of tumor cell metabolic regulation, Department of Veterinary and Biomedical Sciences, University of Nebraska-Lincoln, Lincoln, NE, 08/27/2012
Bonini, M.G., Ablation of nNOS/NOS1 Leads to the Suppression of the Systemic Inflammatory Response Via Suppressor of Cytokine Signaling (SOCS-1) Upregulation, Society for Free Radical Biology and Medicine, 19th annual meeting, San Diego, CA, 11/14/2012 - 11/19/2012
Bonini, M.G., Mechanisms of mitochondria-driven cancer cell reprogramming, National Institute of Environmental Health Sciences (NIEHS/NIH), Research Triangle Park, NC, 01/09/2013
Bonini, M.G., Mechanisms of mitochondria-driven cancer cell reprogramming, National Institute of Health (NIH), Bethesda, MD, 01/16/2013
Bonini, M.G., Mechanisms of oxidative stress-induced endothelial cell reprogramming in pulmonary arterial hypertension, Experimental Biology 2013 (FASEB), Boston, MA, 2013
Bonini, M.G., ) Identification and targeting of the MnSOD/AMPK pathway for the selective killing of cancer cell, National Institutes of Health (NIH), Bethesda, MD, 01/09/2014
Bonini, M.G., The MnSOD/AMPK axis in breast tumorigenesis, Gordon Research Conferences – Oxygen Radicals and Disease, Ventura Beach, CA, 02/09/2014 - 02/14/2014
Bonini, M.G., MnSOD and ROS as drivers of metabolic reprogramming in cancer, National Institutes of Health,, Bethesda, MD, 01/07/2015
Bonini, M.G., MnSOD as a switch mechanism driving differentiation, State University of New York at Albany, Albany, NY, 02/19/2015
Bonini, M.G., Mitochondrial Redox Signaling Regulates Cellular Metabolism and Drives Cancer Progression, 55th Annual Conference, New Orleans, LA, 03/13/2016 - 03/17/2016
Bonini, M.G., Environmental arsenic exposure in the subtype specification of breast cancer, 9th Conference on Metal Carcinogenesis, Lexington, KY, 10/17/2016 - 10/19/2016
Bonini, M.G., Inflammation by Design: Can nuclear transcriptional switches be regulated?, Department of Cell Biology, University of Miami, Miller School of Medicine, Miami, FL, 01/17/2017
Bonini, M.G., SOD2 and ROS: Reprogramming breast cancer for killing, Department of Pharmaceutical Sciences, Eugene Applebaum School of Pharmacy, Wayne State University, Detroit, MI, 02/08/2017
Bonini, M.G., Inflammation by design: Can nuclear transcriptional switches be redox regulated?, Department of Pharmacology, School of Medicine, Vanderbilt University, Nashville, TN, 03/15/2017
Bonini, M.G., Inflammation by design: Can nuclear transcriptional switches be redox regulated?, Department of Pharmacology, Vanderbilt University, Nashville, TN, 03/15/2017
Bonini, M.G., Inflammation by design: Can nuclear transcriptional switches be redox regulated?, IBio Program, Wayne State University, Detroit, MI, 03/29/2017
Bonini, M.G., Environmental Arsenic and breast cancer subtype specification, Department of Environmental Medicine, Langone School of Medicine, Sterling Forest, NY, 04/14/2017
Bonini, M.G., Inflammation by design: Can nuclear transcriptional switches be redox regulated?, Department of Pharmacology and Toxicology, Ernest Mario School of Pharmacy, Rutgers University, Piscataway Township, NJ, 04/27/2017
Bonini, M.G., Inflammation by design: Can nuclear transcriptional switches be redox regulated?, Department of Pharmacology and Toxicology, College of Pharmacy, University of Arizona, Tucson, AZ, 10/04/2017
Bonini, M.G., Inflammation by design: Can nuclear transcriptional switches be redox regulated?, Department of Genetics, College of Medicine, University of Alabama, Birmingham, AL, 10/20/2017
Bonini, M.G., SOD2 acetylation as a novel mitochondrial pathway to stemness reprogramming in cancer, Environmental Health Program, Nicholas School of the Environment, Duke University, Durham, NC, 04/26/2018
 
International
Bonini, M.G., Direct EPR detection of the carbonate radical anion produced in the reaction of peroxynitrite with carbon dioxide, First International Meeting of the South American Group for Free Radical Research, Florianópolis, SC, Brazil, 1999
Bonini, M.G., Nitrogen dioxide and carbonate radical anion: Two emerging radicals in biology, Brazilian Society of Biochemistry and Molecular Biology / Latin American Young Talents in Life Sciences Symposium, Caxambu, MG, Brazil, 2003
Bonini, M.G., Protein-bound free radical imaging in sub-cellular structures, International Union of Biochemistry and Molecular Biology (IUBMB) 10th conference, Salvador, Brazil, 2007
Bonini, M.G., Reactive species, latest and best in detection and definition of their sources and targets; 1998-2012 From the basics of peroxynitrite biochemistry to the mitochondrial mechanisms of AMPK activation in cancer, Invited Guest Professor, State University of Parana, Maringa, PR, Brazil, 09/10/2012 - 09/11/2012
Bonini, M.G., "From peroxynitrite biochemistry to the role of mitochondrial ROS regulation of cancer cell metabolism, 15 years in free radical research", Guest Professor, State University of Parana, Morumbi, Paranavai-PR, Brazil, 2012
Bonini, M.G., Oxidative stress induced dedifferentiation, a generalized mechanism underlying pathologies affected by cellular hyperproliferation?, State University of Maringa, II PBF Symposium, Maringa, PR, Brazil, 09/17/2013 - 09/19/2013
Bonini, M.G., SOCS-1 nitrosation in the mechanism of TLR4 initiated inflammatory response, Butantan Institute, Sao Paulo, SP, Brazil, 09/24/2013
 

MEDICAL COLLEGE TEACHING ACTIVITIES:
Medical Student Education
09/2009 - 12/2012 Taught Medical Pharmacology (University of Illinois)
 
Graduate Student Education
09/2011 - 12/2017 Taught Receptor Pharmacology & Cell Signaling (University of Illinois)
09/2013 - 12/2015 Taught Pharmacology and Biology of the Vessel Wall (University of Illinois)
09/2015 - 12/2017 Taught Cancer Pathobiology (University of Illinois)
09/2015 - 12/2015 Taught Experimental and Diagnostic Methods in Cardiovascular Sciences (University of Illinois)
 

EXTRAMURAL TEACHING:
Continuing Medical Education
09/2004 - 05/2005 UW-Milwaukee, Medical Terminology in the EMR
 
Graduate Student Education
05/2008 - Present Invited Lecturer, Nicholas School of Environmental Sciences, Duke University, Durham, North Carolina.
 

EXTRAMURAL STUDENTS, FACULTY, RESIDENTS, AND CLINICAL/RESEARCH FELLOWS MENTORED:
Undergraduate Students
Mao Mao, Laboratory Technician. Present: Graduate Student (Ph.D.) Bioengineering Program, University of Illinois, 09/30/2009 - 06/30/2013 Research, Accepted for a Ph.D. at Duke, publications, National Presentations
 
Graduate Students
PhD Committees
Farnaz Bakhshi (2011 - 2013). Primary Advisor: Richard Minshall. Current: Tufts Launchpad/Biolabs Liason, University of Illinois at Chicago, 08/01/2008 - 12/30/2013 Nitrosation-dependent caveolin 1 phosphorylation, ubiquitination, and degradation and its association with idiopathic pulmonary arterial hypertension, Publications, Career Advancement.
Tracy Thennes. Primary Advisor: Dolly Mehta, University Of Illinois at Chicago, 07/01/2010 - 06/30/2015, Ph.D. Defense, Publications
Dede Ekoue. Primary Advisor: Alan Diamond, University of Illinois at Chicago, 02/28/2012 - 08/25/2017 Selenoproteins in Cancer Etiology, Publications, Career Advancement
Bryan Blackburn. Primary Advisor: Jacob Haus, University of Illinois at Chicago, 06/01/2012 - 10/10/2017, Publications, national presentations
Ms. Jacqueline Bonds (2014 - present). Doctorate (Ph.D.) Primary Advisor: Orly Lazarov, University of Illinois at Chicago, 06/30/2013 - 07/14/2018, Publications, Ph.D. defense
PhD Students Advised
Andre Luelsdorf P. de Abreu co-mentored with Marcia Consolaro., Universidade Estadual de Maringa amd University of Illinois at Chicago, 01/01/2012 - 12/31/2016 Papilloma virus humano e co-infecção com agentes sexualmente transmissíveis em mulheres com citologia normal e alterada., Publications, PostDoc
Peter Hart. Postdoctoral Researcher at University of Chicago (Ernst Lengyel), University of Illinois at Chicago, 06/30/2012 - 08/22/2015 MnSOD and AMPK in breast cancer progression towards metastasis, Postdoc, Young Investigator Award (SFRBM), Ph.D. Defense.
 
Postdoctoral Students
M. Saqib Baig Current: Assistant Professor and Associate Dean Indian Institute of Technology, New Delhi, University of Illinois at Chicago, 01/01/2010 - 04/01/2014 Research/Career Development, Mirimus research Grant, national and international presentations, publications
Nathan Sieracki, Co-Mentored with Asrar B. Malik, Current: Principal Scientist, Global Expansion Inc., University of Illinois at Chicago, 03/01/2010 - 04/01/2014 Research, Publications, Patent PCT/US2014/016915 Fluoro-boronate derivatives of luciferin for the detection of oxidative stress in living animals
Micaela Vargas - co-mentored with Asrar B. Malik, Current: Director of Pharmacogenomics, Advanced Genomics Inc., University of Illinois at Chicago, 06/01/2010 - 03/30/2013 Research, Publications
Kristine Ansenberger-Fricano Current: Senior Scientist at Abbott, University of Illinois at Chicago, 09/01/2010 - 06/30/2013, Publications, Constance Campbell Memorial Award, Young Investigator Award (SFRBM)
Colt Melton - Currently Attending Physician at teamHealth, University of Illinois at Chicago (co-mentored by Terry vanden Hoek), 07/01/2011 - 06/30/2013 Research/Career Advancement, Ph.D. thesis defense
Alyssa Master, Current: Director of Science & Applications (Nucleus Biologics), University of Illinois at Chicago, 04/01/2014 - 06/01/2015 Research Advisor, Publication, Career Advancement
Sofia Zaichik, research Assistant Profesor at Feinberg School of Medicine, Northwestern University., University of Illinois at Chicago, 07/01/2014 - 12/31/2016 Research Advisor, Career Advancement, Publication in JEM. Career Advancement
Dr. Thomas Gerber (Co-Mentored with Minshall, Richard and Bck-Schimmer, Beatrice)-University of Zurich, Kantonsspital Winterthur, University of Illinois at Chicago, 02/01/2016 - 01/31/2017 Research Advisor, Publications and Career Advancement
 
Residents
Ali Sovari, Current Electrophysiologist (attending Physician) at St John Regional Medical Center, University of Illinois at Chicago, 09/16/2009 - 06/30/2013 Capacity (Research/ teachingmentor), Publications, National Presentations at AHA meetings, Career dvancement
 
Faculty
Benjamin N. Gantner, current: Faculty Member at MCW, University of Illinois at Chicago, 09/16/2009 - 09/03/2018 Research Advisor, Career Advancement,, Publications, National Presentations. faculty Appointment
Euy-Myong Jeong (co-mentored by Samuel Dudley) - Current: Assistant Professor at Warren Alpert School of Medicine, Brown University, University of Illinois at Chicago, 09/16/2009 - 06/30/2013 Research/Career Development, Publications, Appointment as faculty at Brown university
Chenxia He, Current: Faculty Member (Assistant Professor of Research) MCW, University of Illinois at Chicago and MCW, 11/01/2016 - Present Research, Career Development, Publications, Presentations (national), Faculty Appointment
 


BIBLIOGRAPHY
Refereed Journal Publications/Original Papers
1. Bonini MG, Radi R, Ferrer-Sueta G, Ferreira AM, Augusto O. Direct EPR detection of the carbonate radical anion produced from peroxynitrite and carbon dioxide. J Biol Chem. 1999 Apr 16;274(16):10802-6.
2. Santos CX, Bonini MG, Augusto O. Role of the carbonate radical anion in tyrosine nitration and hydroxylation by peroxynitrite. Arch Biochem Biophys. 2000 May 01;377(1):146-52.
3. Martinez GR, Di Mascio P, Bonini MG, Augusto O, Briviba K, Sies H, Maurer P, Röthlisberger U, Herold S, Koppenol WH. Peroxynitrite does not decompose to singlet oxygen ((1)Delta (g)O(2)) andnitroxyl (NO(-)). Proc Natl Acad Sci U S A. 2000 Sep 12;97(19):10307-12. PMCID: PMC27019
4. Bonini MG, Augusto O. Carbon dioxide stimulates the production of thiyl, sulfinyl, and disulfide radical anion from thiol oxidation by peroxynitrite. J Biol Chem. 2001 Mar 30;276(13):9749-54.
5. Bonini MG, Mason RP, Augusto O. The Mechanism by which 4-hydroxy-2,2,6,6-tetramethylpiperidene-1-oxyl (tempol) diverts peroxynitrite decomposition from nitrating to nitrosating species. Chem Res Toxicol. 2002 Apr;15(4):506-11.
6. Augusto O, Bonini MG, Amanso AM, Linares E, Santos CC, De Menezes SL. Nitrogen dioxide and carbonate radical anion: two emerging radicals in biology. Free Radic Biol Med. 2002 May 01;32(9):841-59.
7. Bonini MG, Fernandes DC, Augusto O. Albumin oxidation to diverse radicals by the peroxidase activity of Cu,Zn-superoxide dismutase in the presence of bicarbonate or nitrite: diffusible radicals produce cysteinyl and solvent-exposed and -unexposed tyrosyl radicals. Biochemistry. 2004 Jan 20;43(2):344-51.
8. Augusto O, Bonini MG, Trindade D. Spin trapping of glutathiyl and protein radicals produced from nitric oxide-derived oxidants. Free Radic Biol Med. 2004 May 15;36(10):1224-32.
9. Bonini MG, Miyamoto S, Di Mascio P, Augusto O. Production of the carbonate radical anion during xanthine oxidase turnover in the presence of bicarbonate. J Biol Chem. 2004 Dec 10;279(50):51836-43.
10. Lima ES, Bonini MG, Augusto O, Barbeiro HV, Souza HP, Abdalla DS. Nitrated lipids decompose to nitric oxide and lipid radicals and cause vasorelaxation. Free Radic Biol Med. 2005 Aug 15;39(4):532-9.
11. Bonini MG, Rota C, Tomasi A, Mason RP. The oxidation of 2',7'-dichlorofluorescin to reactive oxygen species: a self-fulfilling prophesy? Free Radic Biol Med. 2006 Mar 15;40(6):968-75.
12. Bonini MG, Siraki AG, Atanassov BS, Mason RP. Immunolocalization of hypochlorite-induced, catalase-bound free radical formation in mouse hepatocytes. Free Radic Biol Med. 2007 Feb 15;42(4):530-40. PMCID: PMC1952183
13. Bonini MG, Siraki AG, Bhattacharjee S, Mason RP. Glutathione-induced radical formation on lactoperoxidase does not correlate with the enzyme's peroxidase activity. Free Radic Biol Med. 2007 Apr 01;42(7):985-92. PMCID: PMC1994934
14. Raines KW, Bonini MG, Campbell SL. Nitric oxide cell signaling: S-nitrosation of Ras superfamily GTPases. Cardiovasc Res. 2007 Jul 15;75(2):229-39.
15. Siraki AG, Bonini MG, Jiang J, Ehrenshaft M, Mason RP. Aminoglutethimide-induced protein free radical formation on myeloperoxidase: a potential mechanism of agranulocytosis. Chem Res Toxicol. 2007 Jul;20(7):1038-45. PMCID: PMC2073000
16. Bhattacharjee S, Deterding LJ, Jiang J, Bonini MG, Tomer KB, Ramirez DC, Mason RP. Electron transfer between a tyrosyl radical and a cysteine residue in hemoproteins: spin trapping analysis. J Am Chem Soc. 2007 Nov 07;129(44):13493-501.
17. He YY, Council SE, Feng L, Bonini MG, Chignell CF. Spatial distribution of protein damage by singlet oxygen in keratinocytes. Photochem Photobiol. 2008 Jan-Feb;84(1):69-74. PMCID: PMC2365760
18. Siraki AG, Deterding LJ, Bonini MG, Jiang J, Ehrenshaft M, Tomer KB, Mason RP. Procainamide, but not N-acetylprocainamide, induces protein free radical formation on myeloperoxidase: a potential mechanism of agranulocytosis. Chem Res Toxicol. 2008 May;21(5):1143-53. PMCID: PMC2766841
19. Stadler K, Bonini MG, Dallas S, Duma D, Mason RP, Kadiiska MB. Direct evidence of iNOS-mediated in vivo free radical production and protein oxidation in acetone-induced ketosis. Am J Physiol Endocrinol Metab. 2008 Aug;295(2):E456-62. PMCID: PMC2519762
20. Bonini MG, Stadler K, Silva SO, Corbett J, Dore M, Petranka J, Fernandes DC, Tanaka LY, Duma D, Laurindo FR, Mason RP. Constitutive nitric oxide synthase activation is a significant route for nitroglycerin-mediated vasodilation. Proc Natl Acad Sci U S A. 2008 Jun 24;105(25):8569-74. PMCID: PMC2438390
21. Stadler K, Bonini MG, Dallas S, Jiang J, Radi R, Mason RP, Kadiiska MB. Involvement of inducible nitric oxide synthase in hydroxyl radical-mediated lipid peroxidation in streptozotocin-induced diabetes. Free Radic Biol Med. 2008 Sep 15;45(6):866-74. PMCID: PMC2613788
22. Chatterjee S, Ehrenshaft M, Bhattacharjee S, Deterding LJ, Bonini MG, Corbett J, Kadiiska MB, Tomer KB, Mason RP. Immuno-spin trapping of a post-translational carboxypeptidase B1 radical formed by a dual role of xanthine oxidase and endothelial nitric oxide synthase in acute septic mice. Free Radic Biol Med. 2009 Feb 15;46(4):454-61. PMCID: PMC2661569
23. Bonini MG, Gabel SA, Ranguelova K, Stadler K, Derose EF, London RE, Mason RP. Direct magnetic resonance evidence for peroxymonocarbonate involvement in the cu,zn-superoxide dismutase peroxidase catalytic cycle. J Biol Chem. 2009 May 22;284(21):14618-27. PMCID: PMC2682909
24. Chatterjee S, Lardinois O, Bonini MG, Bhattacharjee S, Stadler K, Corbett J, Deterding LJ, Tomer KB, Kadiiska M, Mason RP. Site-specific carboxypeptidase B1 tyrosine nitration and pathophysiological implications following its physical association with nitric oxide synthase-3 in experimental sepsis. J Immunol. 2009 Sep 15;183(6):4055-66. PMCID: PMC2804978
25. Kovalenko OA, Caron MJ, Ulema P, Medrano C, Thomas AP, Kimura M, Bonini MG, Herbig U, Santos JH. A mutant telomerase defective in nuclear-cytoplasmic shuttling fails to immortalize cells and is associated with mitochondrial dysfunction. Aging Cell. 2010 Apr;9(2):203-19.
26. Ranguelova K, Bonini MG, Mason RP. (Bi)sulfite oxidation by copper, zinc-superoxide dismutase: Sulfite-derived, radical-initiated protein radical formation. Environ Health Perspect. 2010 Jul;118(7):970-5. PMCID: PMC2920917
27. Ehrenshaft M, Bonini MG, Feng L, Chignell CF, Mason RP. Partial colocalization of oxidized, N-formylkynurenine-containing proteins in mitochondria and Golgi of keratinocytes. Photochem Photobiol. 2010 Jul-Aug;86(4):752-6. PMCID: PMC3615536
28. Chatterjee S, Lardinois O, Bhattacharjee S, Tucker J, Corbett J, Deterding L, Ehrenshaft M, Bonini MG, Mason RP. Oxidative stress induces protein and DNA radical formation in follicular dendritic cells of the germinal center and modulates its cell death patterns in late sepsis. Free Radic Biol Med. 2011 Apr 15;50(8):988-99. PMCID: PMC3051032
29. Toya SP, Li F, Bonini MG, Gomez I, Mao M, Bachmaier KW, Malik AB. Interaction of a specific population of human embryonic stem cell-derived progenitor cells with CD11b+ cells ameliorates sepsis-induced lung inflammatory injury. Am J Pathol. 2011 Jan;178(1):313-24. PMCID: PMC3069906
30. Siddiqui MR, Komarova YA, Vogel SM, Gao X, Bonini MG, Rajasingh J, Zhao YY, Brovkovych V, Malik AB. Caveolin-1-eNOS signaling promotes p190RhoGAP-A nitration and endothelial permeability. J Cell Biol. 2011 May 30;193(5):841-50. PMCID: PMC3105546
31. Duma D, Fernandes D, Bonini MG, Stadler K, Mason RP, Assreuy J. NOS-1-derived NO is an essential triggering signal for the development of systemic inflammatory responses. Eur J Pharmacol. 2011 Oct 01;668(1-2):285-92.
32. Sovari AA, Bonini MG, Dudley SC. Effective antioxidant therapy for the management of arrhythmia. Expert Rev Cardiovasc Ther. 2011 Jul;9(7):797-800. PMCID: PMC4208691
33. Sovari AA, Iravanian S, Dolmatova E, Jiao Z, Liu H, Zandieh S, Kumar V, Wang K, Bernstein KE, Bonini MG, Duffy HS, Dudley SC. Inhibition of c-Src tyrosine kinase prevents angiotensin II-mediated connexin-43 remodeling and sudden cardiac death. J Am Coll Cardiol. 2011 Nov 22;58(22):2332-9. PMCID: PMC3226807
34. Hickok JR, Sahni S, Mikhed Y, Bonini MG, Thomas DD. Nitric oxide suppresses tumor cell migration through N-Myc downstream-regulated gene-1 (NDRG1) expression: role of chelatable iron. J Biol Chem. 2011 Dec 02;286(48):41413-24. PMCID: PMC3308853
35. Sharma NK, Reyes A, Green P, Caron MJ, Bonini MG, Gordon DM, Holt IJ, Santos JH. Human telomerase acts as a hTR-independent reverse transcriptase in mitochondria. Nucleic Acids Res. 2012 Jan;40(2):712-25. PMCID: PMC3258147
36. Mao M, Sudhahar V, Ansenberger-Fricano K, Fernandes DC, Tanaka LY, Fukai T, Laurindo FR, Mason RP, Vasquez-Vivar J, Minshall RD, Stadler K, Bonini MG. Nitroglycerin drives endothelial nitric oxide synthase activation via the phosphatidylinositol 3-kinase/protein kinase B pathway. Free Radic Biol Med. 2012 Jan 15;52(2):427-35. PMCID: PMC3432314
37. Kadiiska MB, Bonini MG, Ruggiero C, Cleland E, Wicks S, Stadler K. Thiazolidinedione treatment decreases oxidative stress in spontaneously hypertensive heart failure rats through attenuation of inducible nitric oxide synthase-mediated lipid radical formation. Diabetes. 2012 Mar;61(3):586-96. PMCID: PMC3282814
38. Chen Z, Bakhshi FR, Shajahan AN, Sharma T, Mao M, Trane A, Bernatchez P, van Nieuw Amerongen GP, Bonini MG, Skidgel RA, Malik AB, Minshall RD. Nitric oxide-dependent Src activation and resultant caveolin-1 phosphorylation promote eNOS/caveolin-1 binding and eNOS inhibition. Mol Biol Cell. 2012 Apr;23(7):1388-98. PMCID: PMC3315804
39. Ranguelova K, Ganini D, Bonini MG, London RE, Mason RP. Kinetics of the oxidation of reduced Cu,Zn-superoxide dismutase by peroxymonocarbonate. Free Radic Biol Med. 2012 Aug 01;53(3):589-94. PMCID: PMC3408790
40. Davis MF, Zhou L, Ehrenshaft M, Ranguelova K, Gunawardena HP, Chen X, Bonini MG, Mason RP, Campbell SL. Detection of Ras GTPase protein radicals through immuno-spin trapping. Free Radic Biol Med. 2012 Sep 15;53(6):1339-45. PMCID: PMC3549333
41. Towner RA, Smith N, Saunders D, Henderson M, Downum K, Lupu F, Silasi-Mansat R, Ramirez DC, Gomez-Mejiba SE, Bonini MG, Ehrenshaft M, Mason RP. In vivo imaging of immuno-spin trapped radicals with molecular magnetic resonance imaging in a diabetic mouse model. Diabetes. 2012 Oct;61(10):2405-13. PMCID: PMC3447912
42. Mason RP, Ganini D, Bonini MG, Ranguelova K. Two hypotheses for the oxidation of SOD1-Cu(I). Free Radic Biol Med. 2012 Nov 15;53(10):1991-2.
43. Ansenberger-Fricano K, Ganini D, Mao M, Chatterjee S, Dallas S, Mason RP, Stadler K, Santos JH, Bonini MG. The peroxidase activity of mitochondrial superoxide dismutase. Free Radic Biol Med. 2013 Jan;54:116-24. PMCID: PMC4155036
44. Hobbs GA, Bonini MG, Gunawardena HP, Chen X, Campbell SL. Glutathiolated Ras: characterization and implications for Ras activation. Free Radic Biol Med. 2013 Apr;57:221-9. PMCID: PMC3985386
45. Dallas S, Block ML, Thompson DM, Bonini MG, Ronaldson PT, Bendayan R, Miller DS. Microglial activation decreases retention of the protease inhibitor saquinavir: implications for HIV treatment. J Neuroinflammation. 2013 May 04;10:58. PMCID: PMC3651327
46. Sovari AA, Rutledge CA, Jeong EM, Dolmatova E, Arasu D, Liu H, Vahdani N, Gu L, Zandieh S, Xiao L, Bonini MG, Duffy HS, Dudley SC Jr. Mitochondria oxidative stress, connexin43 remodeling, and sudden arrhythmic death. Circ Arrhythm Electrophysiol. 2013 Jun;6(3):623-31. PMCID: PMC3716298
47. Sieracki NA, Gantner BN, Mao M, Horner JH, Ye RD, Malik AB, Newcomb ME, Bonini MG. Bioluminescent detection of peroxynitrite with a boronic acid-caged luciferin. Free Radic Biol Med. 2013 Aug;61:40-50. PMCID: PMC3795912
48. Schmidt TT, Tauseef M, Yue L, Bonini MG, Gothert J, Shen TL, Guan JL, Predescu S, Sadikot R, Mehta D. Conditional deletion of FAK in mice endothelium disrupts lung vascular barrier function due to destabilization of RhoA and Rac1 activities. Am J Physiol Lung Cell Mol Physiol. 2013 Aug 15;305(4):L291-300. PMCID: PMC3891015
49. Towner RA, Smith N, Saunders D, Lupu F, Silasi-Mansat R, West M, Ramirez DC, Gomez-Mejiba SE, Bonini MG, Mason RP, Ehrenshaft M, Hensley K. In vivo detection of free radicals using molecular MRI and immuno-spin trapping in a mouse model for amyotrophic lateral sclerosis. Free Radic Biol Med. 2013 Oct;63:351-60.
50. Souza RP, Gimenes F, de Abreu AL, Rocha-Brischiliari SC, de Carvalho MD, Ferreira EC, Bonini MG, Pelloso SM, Consolaro ME. Differences in the mutation of the p53 gene in exons 6 and 7 in cervical samples from HIV- and HPV-infected women. Infect Agent Cancer. 2013 Oct 07;8(1):38. PMCID: PMC3851445
51. Bonini MG, Gantner BN. The multifaceted activities of AMPK in tumor progression--why the "one size fits all" definition does not fit at all? IUBMB Life. 2013 Nov;65(11):889-96.
52. Souza RP, de Abreu AL, Ferreira ÉC, Rocha-Brischiliari SC, de B Carvalho MD, Pelloso SM, Bonini MG, Gimenes F, Consolaro ME. Simultaneous detection of seven sexually transmitted agents in human immunodeficiency virus-infected Brazilian women by multiplex polymerase chain reaction. Am J Trop Med Hyg. 2013 Dec;89(6):1199-202. PMCID: PMC3854900
53. Bakhshi FR, Mao M, Shajahan AN, Piegeler T, Chen Z, Chernaya O, Sharma T, Elliott WM, Szulcek R, Bogaard HJ, Comhair S, Erzurum S, van Nieuw Amerongen GP, Bonini MG, Minshall RD. Nitrosation-dependent caveolin 1 phosphorylation, ubiquitination, and degradation and its association with idiopathic pulmonary arterial hypertension. Pulm Circ. 2013 Dec;3(4):816-30. PMCID: PMC4070841
54. Hecquet CM, Zhang M, Mittal M, Vogel SM, Di A, Gao X, Bonini MG, Malik AB. Cooperative interaction of trp melastatin channel transient receptor potential (TRPM2) with its splice variant TRPM2 short variant is essential for endothelial cell apoptosis. Circ Res. 2014 Jan 31;114(3):469-79. PMCID: PMC3978731
55. Piegeler T, Votta-Velis EG, Bakhshi FR, Mao M, Carnegie G, Bonini MG, Schwartz DE, Borgeat A, Beck-Schimmer B, Minshall RD. Endothelial barrier protection by local anesthetics: ropivacaine and lidocaine block tumor necrosis factor-α-induced endothelial cell Src activation. Anesthesiology. 2014 Jun;120(6):1414-28. PMCID: PMC4284094
56. Gong H, Gao X, Feng S, Siddiqui MR, Garcia A, Bonini MG, Komarova Y, Vogel SM, Mehta D, Malik AB. Evidence of a common mechanism of disassembly of adherens junctions through Gα13 targeting of VE-cadherin. J Exp Med. 2014 Mar 10;211(3):579-91. PMCID: PMC3949568
57. Bonini MG, Consolaro MEL, Hart PC, Mao M, de Abreu ALP, Master AM. Redox control of enzymatic functions: The electronics of life's circuitry. IUBMB Life. 2014 Mar;66(3):167-181.
58. Yang KC, Bonini MG, Dudley SC Jr. Mitochondria and arrhythmias. Free Radic Biol Med. 2014 Jun;71:351-61. PMCID: PMC4096785
59. Bonini MG, Malik AB. Regulating the regulator of ROS production. Cell Res. 2014 Aug;24(8):908-9. PMCID: PMC4123290
60. Gimenes F, Medina FS, Abreu AL, Irie MM, Esquiçati IB, Malagutti N, Vasconcellos VR, Discacciati MG, Bonini MG, Maria-Engler SS, Consolaro ME. Sensitive simultaneous detection of seven sexually transmitted agents in semen by multiplex-PCR and of HPV by single PCR. PLoS One. 2014;9(6):e98862. PMCID: PMC4055596
61. Yang KC, Rutledge CA, Mao M, Bakhshi FR, Xie A, Liu H, Bonini MG, Patel HH, Minshall RD, Dudley SC Jr. Caveolin-1 modulates cardiac gap junction homeostasis and arrhythmogenecity by regulating cSrc tyrosine kinase. Circ Arrhythm Electrophysiol. 2014 Aug;7(4):701-10. PMCID: PMC4198950
62. Bera S, Weinberg F, Ekoue DN, Ansenberger-Fricano K, Mao M, Bonini MG, Diamond AM. Natural allelic variations in glutathione peroxidase-1 affect its subcellular localization and function. Cancer Res. 2014 Sep 15;74(18):5118-26. PMCID: PMC4167490
63. Mao M, Varadarajan S, Fukai T, Bakhshi FR, Chernaya O, Dudley SC Jr, Minshall RD, Bonini MG. Nitroglycerin tolerance in caveolin-1 deficient mice. PLoS One. 2014;9(8):e104101. PMCID: PMC4144835
64. Gimenes F, Souza RP, Bento JC, Teixeira JJ, Maria-Engler SS, Bonini MG, Consolaro ME. Male infertility: a public health issue caused by sexually transmitted pathogens. Nat Rev Urol. 2014 Dec;11(12):672-87.
65. Gimenes F, Teixeira JJ, de Abreu AL, Souza RP, Pereira MW, da Silva VR, Bôer CG, Maria-Engler SS, Bonini MG, Borelli SD, Consolaro ME. Human leukocyte antigen (HLA)-G and cervical cancer immunoediting: a candidate molecule for therapeutic intervention and prognostic biomarker? Biochim Biophys Acta. 2014 Dec;1846(2):576-89.
66. Taetzsch T, Levesque S, McGraw C, Brookins S, Luqa R, Bonini MG, Mason RP, Oh U, Block ML. Redox regulation of NF-κB p50 and M1 polarization in microglia. Glia. 2015 Mar;63(3):423-40. PMCID: PMC4322433
67. Tang H, Chen J, Fraidenburg DR, Song S, Sysol JR, Drennan AR, Offermanns S, Ye RD, Bonini MG, Minshall RD, Garcia JG, Machado RF, Makino A, Yuan JX. Deficiency of Akt1, but not Akt2, attenuates the development of pulmonary hypertension. Am J Physiol Lung Cell Mol Physiol. 2015 Jan 15;308(2):L208-20. PMCID: PMC4338938
68. Hart PC, Mao M, de Abreu AL, Ansenberger-Fricano K, Ekoue DN, Ganini D, Kajdacsy-Balla A, Diamond AM, Minshall RD, Consolaro ME, Santos JH, Bonini MG. MnSOD upregulation sustains the Warburg effect via mitochondrial ROS and AMPK-dependent signalling in cancer. Nat Commun. 2015 Feb 05;6:6053. PMCID: PMC4319569
69. Schläpfer M, Piegeler T, Dull RO, Schwartz DE, Mao M, Bonini MG, Z'Graggen BR, Beck-Schimmer B, Minshall RD. Propofol increases morbidity and mortality in a rat model of sepsis. Crit Care. 2015 Feb 19;19:45. PMCID: PMC4344774
70. Baig MS, Zaichick SV, Mao M, de Abreu AL, Bakhshi FR, Hart PC, Saqib U, Deng J, Chatterjee S, Block ML, Vogel SM, Malik AB, Consolaro ME, Christman JW, Minshall RD, Gantner BN, Bonini MG. NOS1-derived nitric oxide promotes NF-κB transcriptional activity through inhibition of suppressor of cytokine signaling-1. J Exp Med. 2015 Sep 21;212(10):1725-38. PMCID: PMC4577833
71. Hart PC, Ratti BA, Mao M, Ansenberger-Fricano K, Shajahan-Haq AN, Tyner AL, Minshall RD, Bonini MG. Caveolin-1 regulates cancer cell metabolism via scavenging Nrf2 and suppressing MnSOD-driven glycolysis. Oncotarget. 2016 Jan 05;7(1):308-22. PMCID: PMC4808000
72. Fettiplace MR, Kowal K, Ripper R, Young A, Lis K, Rubinstein I, Bonini M, Minshall R, Weinberg G. Insulin Signaling in Bupivacaine-induced Cardiac Toxicity: Sensitization during Recovery and Potentiation by Lipid Emulsion. Anesthesiology. 2016 Feb;124(2):428-42. PMCID: PMC4718826
73. He C, Hart PC, Germain D, Bonini MG. SOD2 and the Mitochondrial UPR: Partners Regulating Cellular Phenotypic Transitions. Trends Biochem Sci. 2016 07;41(7):568-577. PMCID: PMC4930371
74. de Abreu AL, Malaguti N, Souza RP, Uchimura NS, Ferreira ÉC, Pereira MW, Carvalho MD, Pelloso SM, Bonini MG, Gimenes F, Consolaro ME. Association of human papillomavirus, Neisseria gonorrhoeae and Chlamydia trachomatis co-infections on the risk of high-grade squamous intraepithelial cervical lesion. Am J Cancer Res. 2016;6(6):1371-83. PMCID: PMC4937739
75. Ekoue DN, Zaichick S, Valyi-Nagy K, Picklo M, Lacher C, Hoskins K, Warso MA, Bonini MG, Diamond AM. Selenium levels in human breast carcinoma tissue are associated with a common polymorphism in the gene for SELENOP (Selenoprotein P). J Trace Elem Med Biol. 2017 Jan;39:227-233.
76. Oliveira SDS, Castellon M, Chen J, Bonini MG, Gu X, Elliott MH, Machado RF, Minshall RD. Inflammation-induced caveolin-1 and BMPRII depletion promotes endothelial dysfunction and TGF-β-driven pulmonary vascular remodeling. Am J Physiol Lung Cell Mol Physiol. 2017 05 01;312(5):L760-L771. PMCID: PMC5451590
77. Rauscher GH, Silva A, Pauls H, Frasor J, Bonini MG, Hoskins K. Racial disparity in survival from estrogen and progesterone receptor-positive breast cancer: implications for reducing breast cancer mortality disparities. Breast Cancer Res Treat. 2017 Jun;163(2):321-330. PMCID: PMC5410404
78. Ekoue DN, Bera S, Ansong E, Hart PC, Zaichick S, Domann FE, Bonini MG, Diamond AM. Allele-specific interaction between glutathione peroxidase 1 and manganese superoxide dismutase affects the levels of Bcl-2, Sirt3 and E-cadherin. Free Radic Res. 2017 Jun;51(6):582-590. PMCID: PMC5683088
79. Ekoue DN, He C, Diamond AM, Bonini MG. Manganese superoxide dismutase and glutathione peroxidase-1 contribute to the rise and fall of mitochondrial reactive oxygen species which drive oncogenesis. Biochim Biophys Acta Bioenerg. 2017 Aug;1858(8):628-632. PMCID: PMC5689482
80. Kenny TC, Hart P, Ragazzi M, Sersinghe M, Chipuk J, Sagar MAK, Eliceiri KW, LaFramboise T, Grandhi S, Santos J, Riar AK, Papa L, D'Aurello M, Manfredi G, Bonini MG, Germain D. Selected mitochondrial DNA landscapes activate the SIRT3 axis of the UPR to promote metastasis. Oncogene. 2017 08;36(31):4393-4404. PMCID: PMC5542861
81. Zou X, Ratti BA, O'Brien JG, Lautenschlager SO, Gius DR, Bonini MG, Zhu Y. Manganese superoxide dismutase (SOD2): is there a center in the universe of mitochondrial redox signaling? J Bioenerg Biomembr. 2017 Aug;49(4):325-333.
82. Blajszczak C, Bonini MG. Mitochondria targeting by environmental stressors: Implications for redox cellular signaling. Toxicology. 2017 11 01;391:84-89. PMCID: PMC5939563
83. Potje SR, Chen Z, Oliveira SDS, Bendhack LM, da Silva RS, Bonini MG, Antoniali C, Minshall RD. Nitric oxide donor [Ru(terpy)(bdq)NO] induces uncoupling and phosphorylation of endothelial nitric oxide synthase promoting oxidant production. Free Radic Biol Med. 2017 11;112:587-596. PMCID: PMC5647835
84. Mey JT, Blackburn BK, Miranda ER, Chaves AB, Briller J, Bonini MG, Haus JM. Dicarbonyl stress and glyoxalase enzyme system regulation in human skeletal muscle. Am J Physiol Regul Integr Comp Physiol. 2018 02 01;314(2):R181-R190. PMCID: PMC5867671
85. Bonini MG, Sargis RM. Environmental Toxicant Exposures and Type 2 Diabetes Mellitus: Two Interrelated Public Health Problems on the Rise. Curr Opin Toxicol. 2018 Feb;7:52-59. PMCID: PMC5788318
86. Ganini D, Santos JH, Bonini MG, Mason RP. Switch of Mitochondrial Superoxide Dismutase into a Prooxidant Peroxidase in Manganese-Deficient Cells and Mice. Cell Chem Biol. 2018 04 19;25(4):413-425.e6. PMCID: PMC5910218
87. Chen Z, D S Oliveira S, Zimnicka AM, Jiang Y, Sharma T, Chen S, Lazarov O, Bonini MG, Haus JM, Minshall RD. Reciprocal regulation of eNOS and caveolin-1 functions in endothelial cells. Mol Biol Cell. 2018 05 15;29(10):1190-1202. PMCID: PMC5935069
 
Books, Chapters, and Reviews
1. Sovari, A.A., Small, O., Bonini, M.G., Kocheril, A.G., Dudley, S.C. Jr.. Role of Oxidative Stress in Ventricular Arrhythmias in Ventricular Arrhythmias: From Principles to Patients . Chapter 5 pp 77-94.
2. Bonini, M.G., Dull, R.O. and Minshall, R.D.. Caveolin-1 Regulation of Endothelial Nitric Oxide Synthase (eNOS) Function and Oxidative Stress in the Endothelium in Systems Biology of Free Radicals and Antioxidants . pp 1343-1363.
3. Bonds, J.A., Hart, P.C., Minshall, R.D., Lazarov, O., Haus, J.M., and Bonini, M.G.. Type 2 Diabetes Mellitus as a Risk Factor for Alzheimer's Disease in Genes, Environment and Alzheimer's Disease . Chapter 13 pp 387-413.
4. Lee J, Yesilkanal AE, Wynne JP, Frankenberger C, Liu J, Yan J, Elbaz M, Rabe DC, Rustandy FD, Tiwari P, Grossman EA, Hart PC, Kang C, Sanderson SM, Andrade J, Nomura DK, Bonini MG, Locasale JW, Rosner MR. Effective breast cancer combination therapy targeting BACH1 and mitochondrial metabolism. Nature. 2019 04;568(7751):254-258. PMCID: PMC6698916
5. Oliveira SDS, Chen J, Castellon M, Mao M, Raj JU, Comhair S, Erzurum S, Silva CLM, Machado RF, Bonini MG, Minshall RD. Injury-Induced Shedding of Extracellular Vesicles Depletes Endothelial Cells of Cav-1 (Caveolin-1) and Enables TGF-β (Transforming Growth Factor-β)-Dependent Pulmonary Arterial Hypertension. Arterioscler Thromb Vasc Biol. 2019 Jun;39(6):1191-1202.
6. Beyer AM, Bonini MG, Moslehi J. Cancer therapy-induced cardiovascular toxicity: old/new problems and old drugs. Am J Physiol Heart Circ Physiol. 2019 Jul 01;317(1):H164-H167. PMCID: PMC6692734
 
Patents
1. U.S. Patents: UIC-2012-082-01 converted to PCT/US2014/016915 Fluoro-boronate derivatives of luciferin for the detection of oxidative stress in living animals This invention describes a new molecule (composition matter) biosensor to detect peroxynitrite and hydrogen peroxide in real time, in situ in living animals.
2. Provisional Patents: UIC-2013-123-02 (Provisional Patent) SMA-011, a new drug candidate for the treatment of metastatic cancer This invention describes a new molecule (composition matter) drug candidate for the treatment of metastatic breast cancer. It is a dual function mitochondria-targeted antioxidant.
3. Provisional Patents: UIC-2017-009-01 (IP disclosed) EGN-M001 a mitochondria-target pro-drug with metal chelaing activity/ This invention describes a new molecule (composition matter) with properties as a pro-drug. It combines a metal chelator with a TPP+ mitochondrial driver group and is expected to exert powerful anti-cancer effects upon metastatic tumors.
 

jenkins-FCD Prod-410 e9586552fe7f53c71f7923aa6e27aeabbd3c2473