CURRICULUM VITAE
Nancy M. Dahms PhD
Nancy M. Dahms PhD
Professor
Department of Biochemistry
Department of Biochemistry
OFFICE ADDRESS: |
Medical Education Building |
8701 Watertown Plank Rd |
Milwaukee, WI 53226 |
EDUCATION: |
1976 - 1980 BS - Biology, Marquette University, Milwaukee, WI |
1980 - 1986 PhD - Biochemistry, Johns Hopkins University - School of Medicine, Baltimore, MD, (advisor: Gerald Hart) |
POSTGRADUATE TRAINING AND FELLOWSHIP APPOINTMENTS: |
1986 - 1989 Postdoctoral Fellow, (advisor: Stuart Kornfeld), Washington University School of Medicine, St. Louis, MO |
FACULTY APPOINTMENTS: |
1989 - 1995 Assistant Professor of Biochemistry, Department of Biochemistry, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226 |
1989 - 2010 Full Member, Department of Biochemistry, Cancer Center, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226 |
1995 - 2000 Associate Professor of Biochemistry, Department of Biochemistry, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226 |
1999 Tenure award, Department of Biochemistry, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226 |
2000 - Present Professor of Biochemistry, Department of Biochemistry, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226 |
2004 Interim Chairman of Biochemistry, Department of Biochemistry, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226 |
2009 Interim Chairman of Biochemistry, Department of Biochemistry, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226 |
AWARDS AND HONORS: |
1976 - 1980 Dean's List, Marquette University |
1980 - 1985 Predoctoral Fellow, Johns Hopkins University School of Medicine |
1980 Summa Cum Laude, Marquette University |
1980 Phi Beta Kappa |
1986 - 1989 Postdoctoral Fellow, American Cancer Society |
1996 - 2001 Established Investigator, American Heart Association |
2007 - 2012 Outstanding Medical School Teacher, Medical College of Wisconsin |
2011 Outstanding Faculty Service Award, Medical College of Wisconsin |
2012 Women Pioneers in Research Award, Medical College of Wisconsin |
2013 Outstanding Faculty Service Award, Medical College of Wisconsin |
2013 - 2014 Leadership Academy, Medical College of Wisconsin |
2015 Outstanding Medical School Teacher, Medical College of Wisconsin |
2016 Outstanding Graduate School Educator, Medical College of Wisconsin |
2016 Outstanding Medical School Teacher, Medical College of Wisconsin |
2017 Inaugural member Society for Research Excellence, Medical College of Wisconsin |
2017 Outstanding Faculty Service Award, Medical College of Wisconsin |
2019 Rosalind Kornfeld Award for Lifetime Achievement in Glycobiology, Society for Glycobiology |
2020 Outstanding Graduate School Educator, Medical College of Wisconsin |
2022 Outstanding Medical School Teacher, Medical College of Wisonsin |
MEMBERSHIPS IN HONORARY AND PROFESSIONAL SOCIETIES: |
1989 - 2018 American Society for Cell Biology |
1989 - Present American Association for the Advancement of Science |
1991 - Present American Society for Biochemistry and Molecular Biology |
1998 - Present Society for Glycobiology |
EDITORSHIPS/EDITORIAL BOARDS/JOURNAL REVIEWS: |
Editorial Board |
1997 - 2002 The Journal of Biological Chemistry |
2006 - 2018 Experimental Biology and Medicine |
2009 - 2021 Biochimica et Biophysica Acta – General Subjects |
2011 - 2015 Glycobiology |
Journal Review |
Nature Protocols |
Trends in Biochemical Sciences |
Glycoconjugate Journal |
Proceedings of the National Academy of Sciences |
Protein Expression and Purification |
American Journal of Physiology |
Journal of Molecular Biology |
FEBS Journal |
Gene |
Genomics |
Glycobiology |
Proteomics |
The Journal of Cell Biology |
The Journal of Cellular Physiology |
The Journal of Nutrition |
The Journal of Biological Chemistry |
Molecular & Cellular Proteomics |
Molecular Biology of the Cell |
International Journal of Biological Macromolecules |
Evolution & Development |
Nature Communications |
Archives of Biochemistry and Biophysics |
LOCAL/REGIONAL APPOINTED LEADERSHIP AND COMMITTEE POSITIONS: |
1990 - 1994 Member, Animal Care Committee |
1991 - 1993 Member, Medical Scientists Training Program Admissions Committee |
1992 Member, Cancer Center's Brain Tumor Core Center Grant Advisory Committee |
1992 - 1997 Member, Graduate Studies Committee |
1992 Member, Faculty Search Committee, Department of Biochemistry |
1992 - 1995 Recruitment Director, Department of Biochemistry |
1992 - 1995 Member, Armand J. Quick Award Committee, Department of Biochemistry |
1993 - 1995 Chairman, Armand J. Quick Award Committee, Department of Biochemistry |
1993 Member, Faculty Search Committee, Department of Biochemistry |
1994 - Present Member, Radiation Safety Committee |
1995 - 1997 Member, Search Committee for Chair of the Department of Cellular Biology |
1995 - 1997 Graduate Program Director, Department of Biochemistry |
1995 - 1997 Member, Faculty Users Group for Core Cell Culture Facility |
1995 - 1996 Member, Intramural Committee for Review of Department of Microbiology |
1995 - 1997 Member, Graduate School Accreditation Steering Committee |
1999 - 2002 Member, Recruitment Committee: Interdisciplinary Graduate Program in Biomedical Sciences |
1999 - 2002 Member, Nominating Committee |
1999 - 2001 Member, Executive Evaluation Committee: Interdisciplinary Graduate Program in Biomedical Sciences |
1999 Member, Faculty Search Committee, Department of Biochemistry |
1999 - 2002 Member, Curriculum and Evaluation Committee |
2000 Member, Armand J. Quick Award Committee, Department of Biochemistry |
2000 - 2007 Seminar Series Coordinator, Department of Biochemistry |
2000 - 2006 Chair, Radiation Safety Committee |
2000 - 2002 Member, Faculty Council |
2001 - 2002 vice-chairman, Curriculum and Evaluation Committee |
2001 - 2004 Representative, Search Committee for Chair of the Department of Biochemistry |
2002 Member, Cancer Center “review of trainee research paper competition” |
2003 - 2006 Member, Nominating Committee |
2004 - 2006 Member, Faculty Council |
2004 - Present Member, Armand J. Quick Award Committee, Department of Biochemistry |
2004 - 2011 Member, Faculty Council Governance Group |
2004 Vice President, Faculty Council |
2004 Member, Faculty Council ad hoc Committee on Rank and Tenure |
2004 - Present Member, Faculty Search Committee, Department of Biochemistry |
2005 - Present Member, Medical Scientists Training Program Mentoring Committee |
2005 Senior Vice President, Faculty Council |
2005 - Present Member, Promotions and Academic Progress Committee |
2005 Reviewer, Advancing a Healthier Wisconsin-Education Proposals |
2006 - 2007 Member, Evaluation of Proposal to Increase MCW Medical School Class Size |
2006 President, Faculty Council |
2006 - 2007 Member, Search Committee for Dean of the Graduate School |
2007 - 2009 Member, Basic Science Faculty Advisor of the MCW Student Assembly |
2008 - 2014 Member, Faculty Benefits Committee |
2008 - 2011 Member, Faculty Council |
2009 - 2012 Member, Children’s Research Institute Nucleic Acid Extraction Core Executive Committee |
2009 Member, Research Leadership Council |
2010 - 2013 Member, Graduate Studies Council Curriculum and Programs Committee |
2020 - 2023 Member, University Rank and Tenure Committee, Medical College of Wisconsin |
2021 - Present Co-Chair, Cancer Center, Metabolomics Glycomics Initiative, Recruitment Subcommittee |
2021 - Present Member, Cancer Center Metabolomics Glycomics Initiative |
NATIONAL ELECTED/APPOINTED LEADERSHIP AND COMMITTEE POSITIONS: |
1991 Member, Cell Biology Program, National Science Foundation |
1992 Member, Department of Veterans Affairs |
1992 Member, Biochemistry and Endocrinology Study Section, American Cancer Society |
1993 Member, Cell Biology Program, National Science Foundation |
1996 Member, EPSCOR, National Science Foundation |
1997 Member, Biochemistry and Endocrinology Study Section, American Cancer Society |
1998 Member, Medical Biochemistry Study Section, NIH |
1999 Member, Special Emphasis Panel ZRG1 (PBC), NIH |
1999 Member, Pathobiochemistry study section, NIH |
2000 - 2004 study section member, NIH Pathobiochemistry |
2000 Member, EPSCOR, National Science Foundation |
04/2001 external advisor, San Antonio Cancer Institute |
2003 Member, Molecular Biochemistry Program, National Science Foundation |
2003 - 2006 Member, Board of Directors, Society for Glycobiology |
08/2004 Member, The Wellcome Trust |
10/2004 Member, Slovakia, Science and Technology Assistance Agency |
2004 Member, Austrian Science Fund (FWF) |
2004 Member, Pathobiochemistry study section, NIH |
04/2005 Member, P41 grant review, NIH |
2006 Member, Austrian Science Fund (FWF) |
2010 Member, Austrian Science Fund (FWF) |
2011 - 2012 Member, Nominations Committee, Society for Glycobiology |
2012 - 2014 Member, Public Affairs Advisory Committee (PAAC), American Society for Biochemistry and Molecular Biology (ASBMB) |
2013 - 2019 Member, Macromolecular Structure and Function B (MSFB) study section, NIH |
2013 - 2014 Chair, Legislative Issues Subcommittee, Public Affairs Advisory Committee (PAAC), American Society for Biochemistry and Molecular Biology (ASBMB) |
2017 - 2022 Member, Board of Directors, Society for Glycobiology |
2020 President Elect, Society for Glycobiology |
2020 Chair, Awards Committeee, Society for Glycobiology |
2021 - Present Member, Scientific Advisory Board, M6P Therapeutics |
2021 President, Society for Glycobiology |
2022 Member, Awards Committee, Society for Glycobiology |
2022 Chair, Nominations Committee, Society for Glycobiology |
2024 - 2025 Member, Nominations Committee, Society for Glycobiology |
RESEARCH GRANTS/AWARDS/CONTRACTS/PROJECTS: | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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INVITED LECTURES/WORKSHOPS/PRESENTATIONS: |
Local |
Seminar, Department of Cell Biology and Anatomy, Medical College of Wisconsin, Milwaukee, WI, 04/21/1992 |
Regional |
Seminar, Department of Biochemistry and Molecular Biology, University of Wisconsin-Green Bay, Green Bay, WI, 12/03/1993 |
Seminar, Department of Biological Chemistry, University of Health Sciences, Chicago Medical School, North Chicago, IL, 11/1995 |
Seminar, Department of Biology, University of Wisconsin-Whitewater, 02/1997 |
Seminar, Department of Biochemistry and Molecular Biology, University of Illinois-Chicago, 03/12/1998 |
Seminar, Department of Biochemistry, University of Wisconsin–Madison, 10/01/2001 |
Seminar, Department of Chemistry, St. Catherine’s College, St. Paul, MN, 04/25/2003 |
National |
Lysosomes, Gordon Conference, Andover, NH, 06/1992 |
Lysosomes, Gordon Conference, Andover, NH, 07/1994 |
Seminar, Department of Anatomy and Cell Biology, State University of New York Health Science Center, Syracuse, NY, 04/26/1995 |
Lysosomes, Gordon Conference, Andover, NH, 07/1996 |
Seminar, Division of Hematology-Oncology, Washington University School of Medicine, St. Louis, MO, 02/27/1998 |
Seminar, Department of Biochemistry and Biophysics, University of North Carolina--Chapel Hill, 03/17/1998 |
Invited Speaker, Glycobiology, Gordon Conference, 02/21/1999 - 02/26/1999 |
American Heart Association Research Conference, Dallas, TX, 05/06/2000 |
Invited Speaker, Lysosomes, Gordon Conference, 06/25/2000 - 06/30/2000 |
Invited Speaker, Glycobiology, Gordon Conference, 03/02/2003 - 03/07/2003 |
Session Chair, Glycobiology and Extracellular Matrix Symposium “Protein-Glycan Functional Interactions”, American Society for Biochemistry and Molecular Biology (ASBMB annual meeting and centennial celebration), 04/01/2006 - 04/05/2006 |
Invited Speaker, Glycobiology and Extracellular Matrix Symposium “Protein-Glycan Functional Interactions", American Society for Biochemistry and Molecular Biology, 04/05/2006 |
Invited Speaker, Society for Glycobiology, 11/15/2006 - 11/18/2006 |
Seminar, Department of Biology, Johns Hopkins University, Baltimore, MD, 11/30/2006 |
Society for Glycobiology, 11/11/2007 - 11/14/2007 |
Seminar, Department of Biochemistry & Molecular Biology, Complex Carbohydrate Research Center, Athens, GA, 11/30/2007 |
Invited Speaker from poster presentations, Society for Glycobiology, 11/09/2008 - 11/12/2008 |
Invited Speaker, Glycobiology, Gordon Conference, 01/18/2009 - 01/23/2009 |
Invited Speaker, Society for Glycobiology, 11/12/2009 - 11/15/2009 |
Poster Chair & Session Chair, Gordon Conference on Glycobiology, Italy, 11/12/2009 - 11/15/2009 |
Invited speaker from poster presentation, Experimental Biology/American Society for Biochemistry and Molecular Biology, San Diego, CA, 04/21/2012 - 04/25/2012 |
Invited speaker from poster presentations, Gordon Conference on Glycobiology, Ventura, CA, 03/03/2013 - 03/08/2013 |
Seminar, Department of Molecular Biology, University of Wyoming, 02/20/2015 |
Seminar, Department of Biochemistry, University of Utah, 11/14/2016 |
Invited Speaker, Keystone Symposia on Molecular & Cellular Biology “Biologics as Drugs: Novel Strategies for Better Treatments of Human Disease”, Snowbird, UT, 01/22/2017 - 01/26/2017 |
Invited Speaker, Gordon Conference on Glycobiology, Ventura, CA, 03/19/2017 - 03/24/2017 |
Invited Speaker, Experimental Biology/American Society for Biochemistry and Molecular Biology, Chicago, IL, 04/22/2017 - 04/26/2017 |
Symposium Chair & Symposium Organizer, “Glycobiology, Glycan Receptors and Function Glycomics” session, Experimental Biology/American Society for Biochemistry and Molecular Biology, Chicago, IL, 04/22/2017 - 04/26/2017 |
Invited Session Chair, Society for Glycobiology, Portland, OR, 11/05/2017 - 11/08/2017 |
Invited Award Lecture Lifetime Achievement, Society for Glycobiology, Phoenix, AZ, 11/02/2019 - 11/05/2019 |
Invited speaker, 2021 Mid-South Glycoscience Meeting, Oxford, Mississippi, 07/19/2021 |
Organizer and Session Chair, Annual meeting Society for Glycobiology, San Diego, CA, 11/07/2021 - 11/10/2021 |
Invited Speaker and Session Chair, Glycobiology Gordon Conference, Ventura, CA, 03/12/2023 - 03/16/2023 |
Seminar, Department of Biochemistry, Duke University School of Medicine, - 04/24/2023 |
International |
Invited Speaker, carbohydrate-recognition proteins, Biochemical Society Meeting, Dublin, Ireland, 09/13/1995 |
Invited Speaker, Glycostructures in Biosystems V, minisymposium (Carbohydrates in Cellular Transport, Recognition and Disease), Hamburg, Germany, 12/01/2000 |
Invited Speaker, Joint Annual Meeting of the Argentinean Society for Biochemical Research and the Argentinean Biophysical Society, Bariloche, Argentina, 11/17/2003 - 11/21/2003 |
Invited Speaker, joint meeting of The Society for Glycobiology (U.S.) and The Japan Society for Carbohydrate Research, Honolulu, HI, 11/17/2004 - 11/20/2004 |
Poster Chair & Session Chair, Glycobiology, Gordon Conference, Italy, 05/08/2011 - 05/13/2011 |
MEDICAL COLLEGE TEACHING ACTIVITIES: |
Community/Lay Public |
07/27/2006 Lecturer, Apprenticeship in Medicine (AIM) program for high school students (“Drug Detoxification, Tylenol & Alcohol”) |
07/26/2007 Lecturer, Apprenticeship in Medicine (AIM) program for high school students (“Drug Detoxification, Tylenol & Alcohol”) |
07/13/2009 Lecturer, Apprenticeship in Medicine (AIM) program for high school students (“Drug Detoxification, Tylenol & Alcohol”) |
07/26/2010 Lecturer, Apprenticeship in Medicine (AIM) program for high school students (“Drug Detoxification, Tylenol & Alcohol”) |
07/20/2011 Lecturer, Apprenticeship in Medicine (AIM) program for high school students (“Drug Detoxification, Tylenol & Alcohol”) |
Medical Student Education |
1990 - Present Lecturer, Medical Biochemistry (Biochem 201) / Molecules to Cells |
12/2002 - Present Medical Problem Solving Course |
2008 Lecturer, Integrative Grand Rounds |
2011 Lecturer, Cardiovascular/atherosclerosis (PIC) |
2011 Lecturer, Liver fibrosis/heme metabolism (PIC) |
Graduate Student Education |
1991 - 2003 Membrane Biochemistry and Signal Transduction (Biochem 216) |
1991 - Present Lecturer, Techniques in Molecular and Cell Biology (05242) |
1993 - 1996 Graduate Biochemistry (Biochem 202) |
1994 - 2000 Principles of Drug Action I (Pharm 221) |
1994 - 1996 Advanced Cell Biology (CellBio 250) |
2000 - 2007 Molecular Biology of the Cell (16243) |
2000 Contemporary Topics (Biochem 275) |
05/20/2002 Lecturer, Spotlight on Science, “Submission & Review of Scientific Manuscripts” |
2002 - Present Lecturer, Protein Chemistry (02222) |
2005 - Present Lecturer, Biophysical Techniques in Biochemistry (02226) |
2006 - Present Lecturer, Cell Signaling |
2007 - Present Lecturer, Research Ethics Discussion Series (Bioethics 10444A) |
2007 - Present Lecturer, Enzyme Kinetics and Receptor Binding: Theory & Practice (02207) |
2008 - Present Lecturer, Molecular and Cellular Biology (16244) |
2008 Lecturer, Boundaries of Basic and Clinical Science (02400A) |
2009 - Present Lecturer, Biochemistry of the Cell (16202) |
2009 - Present Lecturer, Biochemistry of the Cell |
2020 - Present Lecturer, Protein Chemistry: Applications (02216267) |
MCW STUDENTS, FACULTY, RESIDENTS AND CLINICAL/RESEARCH FELLOWS MENTORED: |
Undergraduate Students |
Juan Alvarez, Medical College of Wisconsin, 1993 AIR minority summer research program |
Deshaun Hill, Medical College of Wisconsin, 1994 AIR minority summer research program |
David Quiles, Medical College of Wisconsin, 1995 ROADS minority summer research program |
Amanda Otieno, Medical College of Wisconsin, 2008 Multicultural summer research training program (MSRTP) |
Ethan Leng, Medical College of Wisconsin, 2009 NIH American Reinvestment & Recovery Act |
Temperance Scott, Medical College of Wisconsin, 2009 Diversity summer health-related research education program (DSHREP) |
Medical Students |
Scott Kulich, Medical College of Wisconsin, 1990 Medical Scientist Training Program |
Pamela Rose, Medical College of Wisconsin, 1991 Medical Scientist Training Program |
Heather Benahmed, Medical College of Wisconsin, 1995 Medical student summer research program |
Kathryn Bollinger, Medical College of Wisconsin, 1996 Medical Scientist Training Program |
Jason Duelge, Medical College of Wisconsin, 1996 Medical student summer research program |
Manish Patel, Medical College of Wisconsin, 2008 Medical student summer research program |
Graduate Students |
PhD Committees |
Zhi Liu, Medical College of Wisconsin, 1993 Biochemistry |
Keith Loeb, Medical College of Wisconsin, 1993 Biochemistry (MSTP) |
Gary Bachowski, Medical College of Wisconsin, 1993 Biochemistry |
Richard Bohnsack, Medical College of Wisconsin, 1993 Biochemistry |
Kathy Krueger, Medical College of Wisconsin, 1993 Microbiology |
Ning Li, Medical College of Wisconsin, 1994 Biochemistry |
Ila Misra, Medical College of Wisconsin, 1995 Biochemistry |
Jean Wojnar, Medical College of Wisconsin, 1995 Biochemistry |
Santanu Bose, Medical College of Wisconsin, 1996 Biochemistry |
Dan Lindner, Medical College of Wisconsin, 1996 Microbiology |
Shawn Balding, Medical College of Wisconsin, 1996 Biochemistry |
David Potter, Medical College of Wisconsin, 1997 Biochemistry |
Jennifer Potter, Medical College of Wisconsin, 1997 Biochemistry |
Anand Ganesan, Medical College of Wisconsin, 1999 Microbiology (MSTP) |
Tara Sander, Medical College of Wisconsin, 2000 Biochemistry |
Elvan Laleli-Sahin, Medical College of Wisconsin, 2001 Biochemistry |
Amy Haas, Medical College of Wisconsin, 2002 Biochemistry |
Andy Vila, Medical College of Wisconsin, 2003 Biochemistry |
Mira Punjabi, Medical College of Wisconsin, 2003 Microbiology |
Yunfei Cai, Medical College of Wisconsin, 2003 Pharmacology |
GiGi Makky, Medical College of Wisconsin, 2004 |
Jason Mercer, Medical College of Wisconsin, 2005 Microbiology |
Rob Balza, Medical College of Wisconsin, 2005 Biochemistry |
Yue Zhang, Medical College of Wisconsin, 2006 Microbiology |
Ryan McAndrew, Medical College of Wisconsin, 2008 Biochemistry |
Kasia Broniowska, Medical College of Wisconsin, 2008 Biophysics |
Qing (Daisy) Deng, Medical College of Wisconsin, 2008 Microbiology |
Malathi Narayan, Medical College of Wisconsin, 2010 Biochemistry |
Kay Ishizuka, Medical College of Wisconsin, 2010 Biochemistry |
Christine Schneider, Medical College of Wisconsin, 2011 Microbiology |
Elizabeth Ntantie, Medical College of Wisconsin, 2012 Pharmacology |
Katie Schmalzer, Medical College of Wisconsin, 2012 Microbiology |
Aaron Baldwin, Medical College of Wisconsin, 2013 Biochemistry |
Nathan May, Medical College of Wisconsin, 2013 Microbiology |
Lalita Shrestha, Medical College of Wisconsin, 2013 Pharmacology |
Abby Kroken, Medical College of Wisconsin, 2013 Microbiology |
Maxime Heroux, Medical College of Wisconsin, 2014 Biochemistry |
Emily Andreae, Medical College of Wisconsin, 2014 Biochemistry |
Alex Chadwick, Medical College of Wisconsin, 2016 Biochemistry |
Mansi Karkhanis, Medical College of Wisconsin, 2016 Biochemistry |
Anthony Getschman, Medical College of Wisconsin, 2016 Biochemistry |
Aye Myat Myat Thinn, Medical College of Wisconsin, 2018 Biochemistry |
Rebecca Holme, Medical College of Wisconsin, 2018 Biochemistry |
Adam Kanack, Medical College of Wisconsin, 2019 Biochemistry |
Aaron Dirck, Medical College of Wisconsin, 2019 Microbiology |
Kelsey Kalous, Medical College of Wisconsin, 2020 Biochemistry |
Sam Zorn, Medical College of Wisconsin, Cell Biology |
Nathan Eaton, Medical College of Wisconsin, - 2021 Cell Biology |
Samantha Chou, Medical College of Wisconsin, Biochemistry |
Linda Berg Luecke, Medical College of Wisconsin, - 2022 Biochemistry |
Andrew Becker, Medical College of Wisconsin, - 2021 Biochemistry |
Eugenia Wulff, Medical College of Wisconsin, Biochemistry |
Tyler Waltz, Medical College of Wisconsin, - 2023 Cell Biology |
PhD Students Advised |
Yan Zhang, Medical College of Wisconsin, 1994 Biochemistry |
Tricia Marron-Terada, Medical College of Wisconsin, 1999 Biochemistry (Molecular Biology Program) |
Mike Hancock, Medical College of Wisconsin, 2002 Biochemistry (Molecular Biology Program) |
Guangjie Sun, Medical College of Wisconsin, 2005 Biochemistry (Interdisciplinary Program) |
Susanna Driscoll, Medical College of Wisconsin, 2005 - 2006 Biochemistry PhD. Candidate (left program, health related) |
Alicia Castonguay, Medical College of Wisconsin, 2011 Biochemistry (Interdisciplinary Program) |
James Miller, Medical College of Wisconsin, 2014 - 2018 Biochemistry (Medical Scientist Training Program) |
MS Committees |
Cathy Conrad, Medical College of Wisconsin, 1997 Biochemistry |
David Knight, Medical College of Wisconsin, 1998 Microbiology |
Amy Haas, Medical College of Wisconsin, 1999 Biochemistry |
Maria Parfenova, Medical College of Wisconsin, 2002 Biophysics |
Gayatri Ganeshan, Medical College of Wisconsin, 2008 Biophysics |
Wei Yong, Medical College of Wisconsin, 2009 Biochemistry |
Alicia Janas, Medical College of Wisconsin, 2010 Microbiology |
Freidrich (Fred) Seewald, Medical College of Wisconsin, 2018 Biochemistry |
MS |
Mark Nicholas, Medical College of Wisconsin, 1998 Biochemistry |
Postdoctoral Students |
Yan Zhang, Ph.D., Medical College of Wisconsin, 1994 |
Linda Olson, Ph.D., Medical College of Wisconsin, 1997 - 1999 |
Sreelatha Reddy, Ph.D, Medical College of Wisconsin, 2000 - 2005 |
Adam Kanack PhD, Medical College of Wisconsin, 2019 - 2021 |
Chen Chen MD/PhD, Medical College of Wisconsin, 2020 |
Faculty |
Dawn Wenzel, PhD, Medical College of Wisconsin, 2021 - Present |
EXTRAMURAL STUDENTS, FACULTY, RESIDENTS, AND CLINICAL/RESEARCH FELLOWS MENTORED: |
High School Students |
David Blackfield, Milwaukee School of Engineering, 2003 SMART team advisor |
Megan Harney, Milwaukee School of Engineering, 2003 SMART team advisor |
Saba Ali, Milwaukee School of Engineering, 2003 SMART team advisor |
Ashley Miller, Milwaukee School of Engineering, 2006 SMART team advisor |
Affnan Mohammed, Milwaukee School of Engineering, 2006 SMART team advisor |
Mary Sales, Milwaukee School of Engineering, 2006 SMART team advisor |
Karen Tiffany, Milwaukee School of Engineering, 2009 SMART team advisor |
Sue Getzel, Milwaukee School of Engineering, 2010 - 2011 SMART team advisor |
Anne Xiong, Milwaukee School of Engineering, 2010 - 2011 SMART team advisor |
Graduate Students |
PhD Committees |
Nina Genthe, Blood Center of Southeastern Wisconsin, 1991 |
Roopa Bhat, Finch University, 2000 |
Promila Pagadala, Rosalind Franklin University, 2008 |
Roshan Ebrahim, University of Cape Town, South Africa, 2008 |
Faculty |
Chen Chen, MD/PhD, LSU - Baton Rouge, 2020 - 2022 |
PATENTS/INVENTION DISCLOSURES: |
MCW Invention Disclosure “Novel Lectin Probe to Identify Unique Post-Translational Modification (Phosphodiester Mannose 6-Phosphate N-Acetylglucosamine)” Filed 8-9-09, Nancy M. Dahms
(invention report # 0046001-09-0007; MCW 1637)
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Invention Disclosure filed with MCW 2-8-16, “Rat model of Fabry Disease”, Nancy M. Dahms
(invention report # 0046001-16-0005; MCW 1907)
|
Provisional Patent #60/404,571 “Localization of the Carbohydrate Recognition Sites of the Insulin-like Growth Factor II/Mannose 6-Phosphate Receptor to Domains 3 and 9 of the Extracytoplasmic Region” Filed 7-25-02, Nancy M. Dahms and Michael K. Hancock
(invention report # 0046001-02-0013; MCW 1184)
|
BIBLIOGRAPHY |
Refereed Journal Publications/Original Papers |
1. * denotes corresponding author |
2. Dahms, N. M. and Schnaar, R. L. (1983). Ganglioside Composition is Regulated During Differentiation in the Neuroblastoma x Glioma Hybrid Cell Line NG108-15. J. Neuroscience 3, 806-817. |
3. Dahms, N. M. and Hart, G. W. (1985). Lymphocyte Function-Associated Antigen 1 (LFA-1) Contains Sulfated N-linked Oligosaccharides. J. Immunol. 134, 3978-3986. |
4. Dahms, N. M. and Hart, G. W. (1986). Influence of Quaternary Structure on Glycosylation: Differential Subunit Association Affects the Site-specific Glycosylation of the Common β-Chain from Mac-1 and LFA-1. J. Biol. Chem. 261, 13186-13196. |
5. Lobel, P., Dahms, N. M., Breitmeyer, J., Chirgwin, J. M., and Kornfeld, S. (1987). Cloning of the Bovine 215-kDa Cation-independent Mannose 6-Phosphate Receptor. Proc. Natl. Acad. Sci. USA 84, 2233-2237. |
6. Dahms, N. M., Lobel, P., Breitmeyer, J., Chirgwin, J. M., and Kornfeld, S. (1987). 46 kd Mannose 6- Phosphate Receptor: Cloning, Expression, and Homology to the 215 kd Mannose 6-Phosphate Receptor. Cell 50, 181-192. |
7. Lobel, P., Dahms, N. M., and Kornfeld, S. (1988). Cloning and Sequence Analysis of the Cation- independent Mannose 6-Phosphate Receptor. J. Biol. Chem. 263, 2563-2570. |
8. Dahms, N. M. and Kornfeld, S. (1989). The Cation-dependent Mannose 6-Phosphate Receptor: Structural Requirements for Mannose 6-Phosphate Binding and Oligomerization. J. Biol. Chem. 264, 11458-11467. |
9. Dahms, N. M., Lobel, P., and Kornfeld, S. (1989). Mannose 6-Phosphate Receptors and Lysosomal Enzyme Targeting. J. Biol. Chem. 264, 12115-12118. |
10. Woessner, Jr., J. F., Dannenberg, Jr., A. M., Pula, P. J., Selzer, M. G., Ruppert, C. L., Higuchi, K., Kajiki, A., Nakamura, M., Dahms, N. M., Kerr, J. S., and Hart, G. W. (1990). Extracellular Collagenase, Proteoglycanase and Products of their Activity, Released in Organ Culture by Intact Dermal Inflammatory Lesions Produced by Sulfur Mustard. J. Invest. Derm. 95, 717-726. |
11. Seetharam, S., Dahms, N. M., Li, N., Ramanujam, K. S., and Seetharam, B. (1991) In vitro Translation and Expression of Renal Intrinsic Factor-Cobalamin Receptor. Biochem. Biophys. Res. Commun. 177, 751- 756. |
12. Ramanujam, K. S., Seetharam, S., Dahms, N. M., and Seetharam, B. (1991) Functional expression of intrinsic factor-cobalamin receptor by renal proximal tubular epithelial cells. J. Biol. Chem. 266, 13135- 13140. |
13. Westlund, B., Dahms, N. M., and Kornfeld, S. (1991) The Bovine Mannose 6-Phosphate/Insulin-Like Growth Receptor. Localization of Mannose 6-Phosphate Binding Sites to Domains 1-3 and 7-11 of the Extracytoplasmic Region. J. Biol. Chem. 266, 23233-23239. |
14. Seetharam, S., Dahms, N. M., and Seetharam, B. (1991) Functional Expression of Transcobalamin II cDNA in Xenopus laevis Oocytes. Biochem. Biophys. Res. Commun.v181, 1151-1155. |
15. Dahms, N. M.*, Rose, P. A., Molkentin, J. D., Zhang, Y., and Brzycki, M. A. (1993) The Bovine Mannose 6- Phosphate/Insulin-like Growth Factor II Receptor. The Role of Arginine Residues in Mannose 6- Phosphate Binding. J. Biol. Chem. 268, 5457-5463. |
16. Dahms, N. M.*, Brzycki-Wessell, M. A., Ramanujam, K. S., Seetharam, B. (1993) Characterization of Mannose 6-Phosphate Receptors (MPRs) from Opossum Liver: Opossum Cation-independent MPR Binds Insulin-like Growth Factor II. Endocrinology 133, 440-446. |
17. Zhang, Y. and Dahms, N. M.* (1993) Site-directed Removal of N-Glycosylation Sites in the Bovine Cation- dependent Mannose 6-Phosphate Receptor. Effects on Ligand Binding, Intracellular Targeting, and Association With BiP. Biochem. J. 295, 841-848. |
18. Dahms, N. M.*, Wick, D., and Brzycki-Wessell, M. A. (1994) The Bovine Mannose 6-Phosphate/Insulin-like Growth Factor II (IGF-II) Receptor. Localization of the IGF-II Binding Site to Domains 5-11. J. Biol. Chem. 269, 3802-3809. |
19. Ramanujam, K. S., Seetharam, S., Dahms, N. M., and Seetharam, B. (1994) Effect of Processing Inhibitors on Cobalamin (Vitamin B12) Transcytosis in Polarized Opossum Kidney Cells. Arch. Biochem. Biophys. 315, 8-15. |
20. Dahms, N. M.*, and Brzycki-Wessell, M. A. (1995) Expression and Characterization of Functional Bovine Cation-dependent Mannose 6-Phosphate Receptors in Baculovirus- infected Insect Cells. Arch. Biochem. Biophys. 317, 497-503. |
21. Zhang, Y., Wick, D. A., Haas, A., Seetharam, B., and Dahms, N. M.* (1995) Regulation of Lysosomal and Ubiquitin Degradative Pathways in Differentiating Human Intestinal Caco-2 Cells. Biochim. Biophys. Acta 1267, 15-24. |
22. Zhang, Y., Wick, D. A., Seetharam, B., and Dahms, N. M.* (1995) Expression of Insulin-like Growth Factor II (IGF-II) and IGF Binding Proteins in Differentiating Human Intestinal Caco-2 Cells. Am. J. Physiol. 269 (Endocrinol. Metab. 32), E804-E813. |
23. Dahms, N. M.*, Seetharam, B., and Wick, D. A. (1996) Expression of Insulin-like Growth Factor (IGF-I) Receptors, IGF-II/Cation-Independent Mannose 6-Phosphate Receptors (CI-MPRs), and Cation-Dependent MPRs in Polarized Human Intestinal Caco-2 Cells. Biochim. Biophys. Acta 1279, 84-92. |
24. McCormick, K. M., Dahms, N. M., and Lough, J. W. (1996) IGF-II/Mannose 6-Phosphate Receptor Expression During Early Heart Development. Developmental Dynamics 207,195-203. |
25. Bose, S., Seetharam, S., Dahms, N. M., and Seetharam, B. (1997) Bipolar Functional Expression of Transcobalamin II Receptor in Human Intestinal Epithelial Caco-2 Cells. J. Biol. Chem. 272, 3538-3543. |
26. Roberts, D. L., Weix, D. J., Dahms, N. M.*, and Kim, J.-J. P*. (1998) Molecular Basis of Lysosomal Enzyme Recognition: Three-Dimensional Structure of the Cation-Dependent Mannose 6-Phosphate Receptor. Cell 93, 639-648. |
27. Marron-Terada, P. G., Brzycki-Wessell, M. A., and Dahms, N. M.* (1998) The Two Mannose 6-Phosphate Binding Sites of the Insulin-Like Growth Factor-II/Mannose 6-Phosphate Receptor Display Different Ligand Binding Properties. J. Biol. Chem. 273, 22358-22366. |
28. Marron-Terada, P. G., Bollinger, K. E., and Dahms, N. M.* (1998) Characterization of Truncated and Glycosylation-Deficient Forms of the Cation-Dependent Mannose 6-Phosphate Receptor Expressed in Baculovirus-Infected Insect Cells. Biochemistry 37, 17223-17229. |
29. York, S. J., Arneson, L. S., Gregory, W. T., Dahms, N. M., and Kornfeld, S. (1999) The Rate of Internalization of the Mannose 6-Phosphate/Insulin-Like Growth Factor II Receptor is Enhanced by Multivalent Ligand Binding. J. Biol. Chem. 274, 1164-1171. |
30. Wick, D. A., Seetharam, B., and Dahms, N. M.* (1999) Biosynthesis and Secretion of the Mannose 6- Phosphate Receptor and Its Ligands in Polarized Human Intestinal Caco-2 Cells. Am. J. Physiol. 277, (Gastrointest. Liver Physiol. 40): G506-G514. |
31. Olson, L. J., Zhang, J., Lee, Y. C., Dahms, N. M., and Kim, J.-J. P. (1999) Structural Basis for Recognition of Phosphorylated High-Mannose Oligosaccharides by the Cation-Dependent Mannose 6-Phosphate Receptor. J. Biol. Chem. 274, 29889-29896. |
32. Olson, L. J., Hancock, M. K., Hubbard, P., Dix, D., Kim, J.-J. P., and Dahms, N. M.* (1999) Mutational Analysis of the Binding Site Residues of the Bovine Cation-Dependent Mannose 6-Phosphate Receptor. J. Biol. Chem. 274, 36905-36911. |
33. Marron-Terada, P. G., Hancock, M. K., Haskins, D. J., and Dahms, N. M.* (2000) Recognition of Dictyostelium discoideum Lysosomal Enzymes is Conferred by the Amino-Terminal Mannose 6-Phosphate Binding Site of the Insulin-Like Growth Factor II/Mannose 6-Phosphate Receptor. Biochemistry 39, 2243- 2253. |
34. Wick, D. A., Seetharam, B., and Dahms, N. M.* (2002) The Basolateral Sorting Signal of the 300kDa Mannose 6-Phosphate Receptor. Am. J. Physiol. 282, G51-G60. |
35. Olson, L. J., Zhang, J., Dahms, N. M., and Kim, J.-J. P. (2002) Twists and Turns of the Cation-Dependent Mannose 6-Phosphate Receptor: Ligand-Bound versus Ligand-Free Receptor. J. Biol. Chem. 277, 10156- 10161. |
36. Hancock, M. K., Haskins, D.J., Sun, G., and Dahms, N. M.* (2002) Identification of Residues Essential for Carbohydrate Recognition by the Insulin-like Growth Factor II/Mannose 6-Phosphate Receptor. J. Biol. Chem. 277, 11255-11264. |
37. Yammani, R. R., Sharma, M., Seetharam, S., Moulder, J. E., Dahms, N. M., and Seetharam, B. (2002) Loss of Albumin and Megalin Binding to Renal Cubilin in Rats Results in Albuminuria After Total-Body Irradiation. Am. J. Physiol. Regul. Integr. Comp. Physiol. 283, R339-R346. |
38. Reddy, S. T. and Dahms, N. M.* (2002) High-Level Expression and Characterization of a Secreted Recombinant Cation-dependent Mannose 6-Phosphate Receptor in Pichia pastoris. Protein Expr. Purific. 26,290-300. |
39. Hancock, M. K., Yammani, R., and Dahms, N. M.* (2002) Localization of the Carbohydrate Recognition Sites of the Insulin-Like Growth Factor II/Mannose 6-Phosphate Receptor to Domains 3 and 9 of the Extracytoplasmic Region. J. Biol. Chem. 277, 47205-47212. |
40. Yammani, R. R., Seetharam, S., Dahms, N. M., and Seetharam, B. (2003) Transcobalamin II Receptor Interacts with Megalin in the Renal Apical Brush Border Membrane. J. Membrane Biol. 193, 57-66 |
41. Reddy, S. T., Kumar, S. N, Haas, A. L., and Dahms, N. M.* (2003) Biochemical and Functional Properties of the Full-Length Cation-Dependent Mannose 6-Phosphate Receptor Expressed in Pichia pastoris. Biochem. Biophys. Res. Commun. 309, 643-651. |
42. Olson, L. J., Yammani, R., Dahms, N. M., and Kim, J.-J. P. (2004) Structure of the uPAR, Plasminogen, and Sugar Binding Sites of the 300 kDa Mannose 6-Phosphate Receptor. EMBO J 23, 2019-2028. |
43. Olson, L. J., Dahms, N. M., and Kim, J.-J. P. (2004) The N-Terminal Carbohydrate Recognition Site of the Cation-Independent Mannose 6-Phosphate Receptor. J. Biol. Chem. 279, 34000-34009. |
44. Reddy, S. T., Chai, W., Childs, R. A, Page, J.D., Feizi, T., and Dahms, N. M.* (2004) Identification of a Low Affinity Mannose 6-Phosphate Binding Site in Domain 5 of the Cation-Independent Mannose 6-Phosphate Receptor. J. Biol. Chem. 279, 38658-38667. |
45. Sun, G., Zhao, H., Kalyanaraman, B., and Dahms, N. M.* (2005) Identification of Residues Essential for Carbohydrate Recognition and Cation Dependence of the 46kDa Mannose 6-Phosphate Receptor. Glycobiology 15, 1136-1149. |
46. Chavez, C. A., Bohnsack, R. N., Kudo, M., Gotschall, R. R., Canfield, W. M., and Dahms,N. M.* (2007) Domain 5 of the Cation-Independent Mannose 6-Phosphate Receptor Preferentially Binds Phosphodiesters (Mannose 6-Phosphate N-Acetylglucosamine Ester). Biochemistry 46, 12604-12617 |
47. Olson, L. J., Hindsgaul, O., Dahms, N. M., and Kim, J.-J. P. (2008) Structural Insights into the Mechanism of pH-dependent Ligand Binding and Release by the Cation-Dependent Mannose 6-Phosphate Receptor. J. Biol. Chem. 283, 10124-10134 |
48. Boonen, M., Vogel, P., Platt, K. A., Dahms, N. M., and Kornfeld, S. (2009) Mice Lacking Mannose 6-Phosphate Uncovering Enzyme Activity have a Milder Phenotype than Mice Deficient for GlcNAc-1-Phosphotransferase Activity Mol. Biol. Cell 20, 4381-4389 |
49. Song, X., Lasanajak, Y., Olson, L. J., Boonen, M., Dahms, N. M., Kornfeld, S., Cummings, R. D., and Smith, D. F. (2009) Glycan Microarray Analysis of P-Type Lectins Reveals Distinct Phospho-Mannose Glycan Recognition J. Biol. Chem. 284, 35201-35214 |
50. Bohnsack, R. N., Song, X., Olson, L. J., Kudo, M., Gotschall, R. R., Canfield, W. M., Cummings, R. D., Smith, D., F.*, and Dahms, N. M*. (2009) Cation-Independent Mannose 6-Phosphate Receptor: A Composite of Distinct Phosphomannosyl Binding Sites J. Biol. Chem. 284, 35215-35226 |
51. Olson, L. J., Sun, G., Bohnsack, R. N., Peterson, F. C., Dahms, N. M.*, and Kim, J.-J. P.* (2010) Intermonomer Interactions are Essential for Lysosomal Enzyme Binding by the Cation-Dependent Mannose 6-Phosphate Receptor. Biochemistry 49, 236-246. [Manuscript highlighted on the journal's home page] |
52. Bohnsack, R. N., Patel, M., Olson, L. J., Twinning, S. S., and Dahms, N. M.* (2010) Residues Essential for Plasminogen Binding by the Cation-Independent Mannose 6-Phosphate Receptor. Biochemistry 49, 635-644 |
53. Olson, L. J., Peterson, F. C., Castonguay, A., Bohnsack, R. N., Kudo, M., Gotschall, R. R., Canfield, W. M., Volkman, B. F., and Dahms, N. M.* (2010) Structural Basis for Recognition of Phosphodiester-containing Lysosomal Enzymes by the Cation-Independent Mannose 6-Phosphate Receptor. Proc. Natl. Acad. Sci. 107, 12493-12498 [Article highlighted in PNAS weekly series "In This Issue" Proc. Natl. Acad. Sci. 107,12407- 12408] |
54. Song, X., Heimburg-Molinaro, J., Dahms, N. M., Smith, D. F., and Cummings, R. D. (2012) Preparation of a mannose-6-phosphate glycan microarray through fluorescent derivatization, phosphorylation, and immobilization of natural high-mannose N-glycans and application in ligand identification of P-type lectins. Methods Mol Biol 808, 137-148. |
55. Castonguay, A., Lasanajak, Y., Song, X., Olson, L. J., Cummings, R. D., Smith, D.F., and Dahms, N. M.* (2012) The Glycan Binding Properties of the Cation-Independent Mannose 6-Phosphate Receptor are Evolutionary Conserved. Glycobiology 22, 983-996. |
56. Maga, J.A., Zhou, J., Kambampati, R., Peng, S., Wang, X., Bohnsack, R. N., Thomm, A., Golata, S., Tom, P., Dahms, N. M., Byrne, B. J., and LeBowitz, J. H. (2013) Glycosylation-Independent Lysosomal Targeting of Acid -Glucosidase Enhances Muscle Glycogen Clearance in Pompe Mice. J. Biol. Chem. 288, 1428-1438. |
57. Olson, L.J., Alculumbre, S.G., Peterson, F.C., Stigliano, I.D., Caramelo, J.J., Parodi, A.J., D'Allesio, C*., and Dahms, N.M.* (2013) Structure of the Lectin MRH Domain of Glucosidase II, an Enzyme that Regulates Glycoprotein Folding Quality Control in the Endoplasmic Reticulum. J. Biol. Chem. 288, 16460- 16475. |
58. Bohnsack, R. N., Warejcka, D. J., Wang, L., Gillespie, S. R., Bernstein, A. M., Twining, S. S.*, and Dahms, N. M.* (2014) Expression of Insulin-like Growth Factor 2 Receptor (IGF2R) in Corneal Keratocytes during Differentiation and in Response to Wound Healing. Investigative Ophthalmology & Visual Science 55, 7697-7708. |
59. Olson, L. J., Castonguay, A. C., Lasanajak, Y., Peterson, F. C., Cummings, R. D., Smith, D.F., and Dahms, N. M.* (2015) Identification of a Fourth Mannose 6-Phosphate Binding Site in the Cation- Independent Mannose 6-Phosphate Receptor. Glycobiology 25, 591-606 |
60. Olson, L. J., Jensen, D. R., Volkman, B. F., Kim, J. J.-P., Peterson, Gundry, R.L., and Dahms, N. M.* (2015) Bacterial expression of the phosphodiester-binding site of the cation-independent mannose 6- phosphate receptor for crystallographic and NMR studies. Protein Expression and Purification 111, 91-97 |
61. Olson, L. J.*, Orsi, R., Peterson, F.C., Parodi, A. J., Kim, J.-J. P., D'Alessio, C and Dahms, N. M.* (2015) Crystal Structural and Functional Analyses of Glucosidase II's Lectin Domain: Insights into Oligomannose Recognition. Biochemistry 54, 4097-4111 |
62. Olson, LJ,* and Dahms, NM (2018) Cloning, Expression and Purification of the Glycosylated Transmembrane Protein, Cation-dependent Mannose 6-phosphate Receptor, from Sf9 Cells Using the Baculovirus System Methods Mol Biol 1722, 105-116 PMID: 29264801 |
63. Baldwin AC, Naatz A, Bohnsack RN, Bartosiak JT, Oleson BJ, Hansen PA, Dahms NM*, Corbett JA*. (2018) Cation-independent Mannose 6-Phosphate Receptor Deficiency Enhances β-Cell Susceptibility to Palmitate. Mol Cell Biol Mar 29;38(8). pii: e00680-17. doi: 10.1128/MCB.00680-17. Print 2018 Apr 15. PMID: 29378831 |
64. Miller JJ, Aoki K, Moehring F, Murphy CA, O'Hara CL, Tiemeyer M*, Stucky CL*, Dahms NM*. (2018) Neuropathic Pain in a Fabry Disease Rat Model. JCI Insight Mar 22;3(6). pii: 99171. doi: 10.1172/jci.insight.99171 PMID: 29563343 |
65. Miller, JJ, Aoki, K, Mascari, CA, Beltrame, AK, Sokumbi, O, North, PE, Tiemeyer, M, Kriegel, AJ*, Dahms, NM* (2019) α-Galactosidase A-Deficient Rats Accumulate Glycosphingolipids and Develop Cardiorenal Phenotypes of Fabry Disease. FASEB J. Jan;33(1):418-429. doi: 10.1096/fj.201800771R. Epub 2018 Jul 6. PMID: 29979634 |
66. Miller JJ, Aoki K, Reid CA, Tiemeyer M, Dahms NM*, Kassem IS*. (2019) α-Galactosidase A-Deficient
Rats Develop Ocular Manifestations of Fabry Disease. Sci Rep. Jun 28;9(1):9392. doi: 10.1038/s41598-019-45837-1. PMID: 31253878 |
67. Olson LJ*, Misra SK, Ishihara M, Battaile KP, Grant OC, Sood A, Woods RJ, Kim JP, Tiemeyer M, Ren G, Sharp JS, Dahms NM*. (2020). Allosteric Regulation of Lysosomal Enzyme Recognition by the Cation-independent Mannose 6-Phosphate Receptor. Commun Biol. Sep 9;3(1):498. doi: 10.1038/s42003-020-01211-w. PMID: 32908216 |
68. Beltrame AK, Dahms NM, Runge CL. (2021) Auditory Brainstem Responses in Aging Dark Agouti Rats. Biosci Rep. Feb 26;41(2):BSR20202724. doi: 10.1042/BSR20202724. PMID: 33506259 |
69. Miller JJ, Bohnsack RN, Olson LJ, Ishihara M, Aoki K, Tiemeyer M*, and Dahms NM*. (2021) Tissue Plasminogen Activator is a Ligand of Cation-independent Mannose 6-Phosphate Receptor and Consists of Glycoforms that Contain Mannose 6-Phosphate. Sci Rep Apr 15;11(1):8213 PMID: 33859256 |
70. Kanack AJ, Aoki K, Tiemeyer M, Dahms NM*. Platelet and myeloid cell phenotypes in a rat model of Fabry disease. (2021) FASEB J. 2021;00:e21818. https://doi.org/10.1096/fj.202001727RR PMID: 34320241
|
71. Chen Y, Barbierie JT, Dahms NM, Chen C. Multiple Domains of Staphylococcal Superantigen-like Protein 11 (SSL11) Contribute to Neutrophil Inhibition Biochemistry 2022 Mar 14.
doi: 10.1021/acs.biochem.2c00018. Online ahead of print PMID: 35285627 |
Books, Chapters, and Reviews |
1. Dahms, N. M. (1996) Insulin-like Growth Factor II/Cation-Independent Mannose 6-Phosphate Receptor and Lysosomal Enzyme Recognition. Biochem. Soc. Trans. 24, 136-141. |
2. Marron-Terada, P. G. and Dahms, N. M. (2000) P-Type Lectins and Lysosomal Enzyme Trafficking in Oligosaccharides in Chemistry and Biology: A Comprehensive Handbook. (edited by B. Ernst, G. W. Hart, and P. Sinay) Wiley-VCH, pp. 563-577. |
3. Kim, J.-J. P. and Dahms, N. M. (2000) The Cation-Dependent Mannose 6-Phosphate Receptor in Mammalian Carbohydrate Recognition Systems (edited by P.R. Crocker, Series Results and Problems in Cell Differentiation) Springer-Verlag, pp. 39-56. |
4. Dahms, N. M.* and Hancock, M. J. (2002) P-Type Lectins. Biochim. Biophys. Acta 1572, 317-340 |
5. Ghosh, P., Dahms, N. M., and Kornfeld, S. (2003) Mannose 6-Phosphate Receptors: New Twists in the Tale. Nature Rev. Mol. Cell Biol. 4, 202-212. |
6. Dahms, N. M*., Olson, L. J. and Kim, J.-J. P*. (2008) P-Type Lectins and Lysosomal Enzyme Targeting in Animal Lectins: A Functional View (edited by G.R. Vasta and H. Ahmed) |
7. Dahms, N. M.*, Olson, L. J. and Kim, J.-J. P*. (2008) Strategies for Carbohydrate Recognition by the Mannose 6-Phosphate Receptors. Glycobiology 18, 664-678 |
8. Kim, J.-J. P*, Olson, L. J., and Dahms, N. M*. (2009) Carbohydrate Recognition by the Mannose 6-Phosphate Receptors. Current Opinion in Structural Biology 19, 534-543 |
9. Castonguay, A.C., Olson, L. J., and Dahms, N. M. (2011) Mannose 6-Phosphate Receptor Homology (MRH) Domain-Containing Lectins in the Secretory Pathway. Biochim Biophys Acta 1810, 815-826. |
10. Dahms, N. M. (1996) Insulin-like Growth Factor II/Cation-Independent Mannose 6-Phosphate Receptor and Lysosomal Enzyme Recognition. Biochem. Soc. Trans. 24, 136-141. |
11. Marron-Terada, P. G. and Dahms, N. M.* (2000) P-Type Lectins and Lysosomal Enzyme Trafficking in Oligosaccharides in Chemistry and Biology: A Comprehensive Handbook. (edited by B. Ernst, G. W. Hart, and P. Sinay) Wiley-VCH, pp. 563-577. |
12. Kim, J.-J. P. and Dahms, N. M.* (2000) The Cation-Dependent Mannose 6-Phosphate Receptor in Mammalian Carbohydrate Recognition Systems (edited by P.R. Crocker, Series Results and Problems in Cell Differentiation) Springer-Verlag, pp. 39-56. |
13. Dahms, N. M.* and Hancock, M. J. (2002) P-Type Lectins. Biochim. Biophys. Acta 1572, 317-340 |
14. Ghosh, P., Dahms, N. M., and Kornfeld, S. (2003) Mannose 6-Phosphate Receptors: New Twists in the Tale. Nature Rev. Mol. Cell Biol. 4, 202-212. |
15. Dahms, N. M.*, Olson, L. J. and Kim, J.-J. P*. (2008) P-Type Lectins and Lysosomal Enzyme Targeting in Animal Lectins: A Functional View (edited by G.R. Vasta and H. Ahmed) CRC Press). |
16. Dahms, N. M.*, Olson, L. J. and Kim, J.-J. P*. (2008) Strategies for Carbohydrate Recognition by the Mannose 6-Phosphate Receptors. Glycobiology 18, 664-678 |
17. Kim, J.-J. P*, Olson, L. J., and Dahms, N. M*. (2009) Carbohydrate Recognition by the Mannose 6- Phosphate Receptors. Current Opinion in Structural Biology 19, 534-543 |
18. Castonguay, A.C., Olson, L. J., and Dahms, N. M.* (2011) Mannose 6-Phosphate Receptor Homology (MRH) Domain-Containing Lectins in the Secretory Pathway. Biochim Biophys Acta 1810, 815-826. |
19. Olson, L.J. and Dahms, N.M. (2014) Mannose 6-Phosphate Receptors in "Glycoscience: Biology and Medicine" (SpringerReference, Naoyuki Taniguchi, Tamao Endo, Gerald Hart, Peter Seeberger, and Chi-Huey Wong, editors) |
20. http://www.springerreference.com/docs/html/chapterdbid/395389.html |
21. D'Allesio, C* and Dahms, N.M.* (2015) Glucosidase II and MRH-Domain Containing Proteins in the Secretory Pathway. Current Protein & Peptide Science (Special Thematic issue "Molecular and Cellular Glycosciences" ) 16, 31-48 |
22. Dahms, N.M (2015) Muscle Targeting "Biobetters: Protein Engineering to Approach the Curative" (invited book chapter, Amy Rosenberg and Barthelemy Demeule, editors; series entitled "Advances in Pharmaceutical Sciences") |
23. Miller JJ, Kanack AJ, Dahms NM*. (2020) Progress in the understanding and treatment of Fabry disease. Biochim Biophys Acta Gen Subj. Jan;1864(1):129437. doi: 10.1016/j.bbagen.2019.129437. Epub 2019 Sep 14. PMID: 31526868 |
24. Dahms N, Braulke T, and Varki A. (2022) P-Type Lectins in "Essentials of Glycobiology", 4th Edition. Cold Spring Harbor Laboratory Press; Chapter 33. PMID: 35536959 |
Abstracts |
1. Dahms, N. M. and Schnaar, R. L. (1982). Spontaneous and Induced Differentiation of Neuroblastoma x Glioma Hybrid Clone NG108-15:Effects on Ganglioside Patterns. Society for Neuroscience Abstracts 7, 696 abstract #224.18. |
2. Dahms, N. M. and Hart, G. W. (1983). Developmental Changes in the Biosynthesis of Glycosaminoglycans by Thymic Lymphocytes and Epithelial Cells. Federation Proceedings 42, 2198 abstract #2574. |
3. Dahms, N. M. and Hart, G. W. (1984). Synthesis of Sulfated Glycoproteins by Lymphocytes. The Society of Complex Carbohydrates, Abstract #60. |
4. Dahms, N. M. and Hart, G. W. (1985). Effects of Subunit Association on Glycosylation: Studies on the Shared Chain of LFA-1 and Mac-1. Glycoconjugates: Proceedings of the VIIIth International Symposium 1, 199. |
5. Dahms, N. M., Ramanujam, K., and Seetharam, B. (1990). Expression and Acylation of Mannose 6-Phosphate Receptors in Human Colon Adenocarcinoma (Caco-2) Cells. American Gastroenterological Association, Abstract #464. |
6. Zhang, Y. and Dahms, N. M. (1991). Properties of Mutated Bovine Cation-dependent Mannose 6-Phosphate Receptors Lacking Various Asparagine-linked Glycosylation Sites. J. Cell Biol. 115, 205a, Abstract #1192. |
7. Brzycki, M. and Dahms, N. M. (1991). Characterization of the Recombinant Extracytoplasmic Domain of the Bovine Cation-dependent Mannose 6-Phosphate Receptor Produced in a Baculovirus Expression System. J. Cell Biol. 115, 205a, Abstract #1191. |
8. Brzycki, M. A. and Dahms, N. M. (1992) Characterization of the Insulin-like Growth Factor II Binding Site of the Bovine Mannose 6-Phosphate/Insulin-like Growth Factor II Receptor. Mol. Biol. Cell 3, 297a, Abstract #1722. |
9. Zhang, Y. and Dahms, N. M. (1993) Expression of Mannose 6-Phosphate Receptors and Their Ligands in Differentiating Human Colon Adenocarcinoma (Caco-2) Cells. FASEB J. 7, A1100, Abstract #279 |
10. Zhang, Y., Haas, A. L., and Dahms, N. M. (1993) Regulation of the Expression of Ubiquitin Cross-Reactive Protein (UCRP) and Its Conjugates During Human Colon Adenocarcinoma (Caco-2) Cellular Differentiation. Mol. Biol. Cell 4, 306a, Abstract #1776 |
11. Wick, D. A., Seetharam, B., and Dahms, N. M. (1994) Surface Distribution of Mannose 6-Phosphate Receptors in Polarized Human Adenocarcinoma (Caco-2) Cells. FASEB J. 8, A1405, Abstract #853 |
12. Zhang, Y., Seetharam, B., and Dahms, N. M. (1994) Expression of Insulin-like Growth Factor Binding Proteins in Differentiating Human Intestinal Caco-2 Cells. Mol. Biol. Cell 5, 137a, Abstract #794 |
13. Brzycki-Wessell, M., Hill, D., Alvarez, J., Messner, D., and Dahms, N. M. (1994) Characterization of Monoclonal Antibodies Specific for the Mannose 6-Phosphate/Insulin- Like Growth Factor II Receptor. Mol. Biol. Cell 5, 435a, Abstract #2532 |
14. Marron-Terada, P. G., Brzycki-Wessell, M. A., and Dahms, N. M. (1995) Sorting of Lysosomal Enzymes by Mutant Insulin-Like Growth Factor II/Mannose 6-Phosphate Receptors. Mol. Biol. Cell 6, 105a, Abstract #608 |
15. Roberts, D. L., Dahms, N. M., and Kim, J.J. (1997) Crystallization and Structure Determination of a Functional Bovine Cation-Dependent Mannose 6-Phosphate Receptor. Am. Chemical Society. |
16. Roberts, D. L., Dahms, N. M., and Kim, J.J. (1997) Crystallization and Structure Determination of a Functional Bovine Cation-Dependent Mannose 6-Phosphate Receptor. FASEB J. 11, A1443, Abstract #3431 |
17. Marron-Terada, P. G., Brzycki-Wessell, M. A., and Dahms, N. M. (1997) Inefficient Targeting of Lysosomal Enzymes by Mutant Insulin-Like Growth Factor II/Mannose 6- Phosphate Receptors. FASEB J. 11, A927, Abstract #409 |
18. Marron-Terada, P. G., Haskins, D. J., and Dahms, N. M. (1997) Expression of Truncated Insulin-Like Growth Factor II/Mannose 6-Phosphate Receptor in Baculovirus-Infected Insect Cells. Mol. Biol. Cell 8, 294a, Abstract #1705 |
19. Hancock, M. K., Olson, L. J., Dix, D. R., Hubbard, P. A., Kim, J.-J. P., and Dahms, N. M. (1998) Role of Amino Acids in Carbohydrate Recognition by the Cation-Dependent Mannose 6-Phosphate Receptor. Mol. Biol. Cell 9, 79a, Abstract #454 |
20. Olson, L., Zhang, J., Lee, Y. C., Dahms, N. M., and Kim, J.-J. P. (1999) Structure of a Functional Cation-Dependent Mannose 6-Phosphate Receptor Bound to Pentamannosyl Phosphate. ACA #W0190 |
21. Hancock, M. K., Haskins, D. J., Sun, G., and Dahms, N. M. (2000) Identification of Residues Essential for Carbohydrate Recognition by the Insulin-Like Growth Factor II/Mannose 6-Phosphate Receptor. FASEB J. 14(8), A1422, Abstract #636 |
22. Kim, J.-J. P., Olson, L. J., Zhang, J., and Dahms, N. M. (2001) The Twists and Turns of the CD-MPR in the Ligand-Bound Versus Ligand-Free State. Glycobiology 11, 880, Abstract # 51 |
23. Reddy, S. T. and Dahms, N. M. (2002) Large-Scale Expression and Characterization of a Secreted Recombinant Cation-Dependent Mannose 6-Phosphate Receptor in Pichia pastoris. FASEB J. 16, 35, Abstract #LB171 |
24. Sun, G. and Dahms, N. M. (2002) Role of Specific Amino Acids of the Cation-dependent Mannose 6-Phosphate Receptor (CD-MPR) in Lysosomal Enzyme Recognition. Glycobiology 12, 701-702, Abstract #178. |
25. Reddy, S. T., Chai, W., Childs, R. A, Feizi, T., and Dahms, N. M. (2003) Identification of a Low-Affinity Mannose 6-Phosphate Binding Site in Domain 5 of the Cation-Independent Mannose 6-Phosphate Receptor. Glycobiology 13, 869, Abstract #161 |
26. Sun, G. and Dahms, N. M. (2003) Cation Dependence of the 46kDa Mannose 6- Phosphate Receptor. Glycobiology 13, 861, Abstract #132 |
27. Dahms, N. M. (2003) The Multi-Facted Mannose 6-Phosphate Receptors. Biocell 27 (supplement I), 32, Abstract #S2 |
28. Dahms, N. M. and Kim, J.-J. P. (2004) Strategies for Phosphomannosyl Recognition. Glycobiology 14, 1057, Abstract # 13 |
29. Chavez, C. A., Driscoll, S. G., and Dahms, N. M. (2005) Role of the Low Affinity Mannose 6-Phosphate Binding Site in the Cation-Independent Mannose 6-Phosphate Receptor. Glycobiology 15, 1215, Abstract # 119 |
30. Bohnsack, R. N. and Dahms, N. M. (2006) Ectodomain Shedding of the Insulin-Like Growth Factor II/Mannose 6-Phosphate Receptor (IGF-II/MPR). FASEB J. 20, A965, Abstract #626.5 |
31. Dahms, N. M. (2006) Building a Lysosome: a Story of Sweetness and Diversion. FASEB J. 20, A1306, Abstract #805.1 |
32. Dahms, N. M. (2006) Structural Snapshots of the Mannose 6-Phosphate Receptors. Glycobiology 16, 1106, Abstract # 9 |
33. Dahms, N. M., Chavez, C. A., Bohnsack, R. N., Kudo, M., Gotschall, R. R., and Canfield, W. M. (2007) Domain 5 of the Cation-Independent Mannose 6-Phosphate Receptor Preferentially Binds Phosphodiesters (Man-P-GlcNAc). Glycobiology 17,1272, Abstract # 268 |
34. Bohnsack, R. N., Twining, S. S., and Dahms, N. M. (2007) Conformational Regulation of Plasminogen Binding to the Cation-Independent Mannose 6-Phosphate Receptor. Mol. Biol. Cell Abstract # 288 |
35. Olson, L.J. , Hindsgaul, O., Dahms, N. M. and Kim, J.-J. P. (2007) Structural Insights into the Mechanism of pH-Dependent Ligand Binding by the 46kDa Cation-Dependent Mannose 6-Phosphate Receptor. Glycobiology 17, 1270, Abstract # 261 |
36. Olson, L. J., Peterson, F. C., Kudo, M., Gotschall, R. R., Canfield, W. M., Volkman, B. F., and Dahms, N. M. (2008) Solution Structure of Domain 5 of the 300 kDa Cation-Independent Mannose 6-Phosphate Receptor Reveals Mode of Phosphodiester Recognition. Glycobiology 18, 993 Abstract #216 |
37. Bohnsack, R. N., Olson, L. J., Kudo, M., Gotschall, R. R., Canfield, W. M., and Dahms, N. M. (2008) Interaction of the 300 kDa Cation-Independent Mannose 6-Phosphate Receptor with Lysosomal Enzymes containing Phosphodiesters Glycobiology 18, 944 Abstract # 20 |
38. Dahms, N. M., Bohnsack, R. N., Song, X., Olson, L. J., Kudo, M., Gotschall, R. R., Canfield, W. M., Cummings, R., and Smith, D. (2009) Cation-Independent Mannose 6-Phosphate Receptor: A Composite of Distinct Phosphomannosyl Binding Sites Glycobiology 19, 1293 Abstract # 18 |
39. Song, X., Lasanajak, Y., Olson, L., Boonen, M., Dahms, N. M., Olson, L. J., Kornfeld, S., Cummings, R., and Smith, D. (2009) Glycan Microarray Analysis of P-Type Lectins Reveals Distinct Phospho-Mannose Glycan Recognition Glycobiology 19, 1353 Abstract # 221 |
40. Castonguay, A., Olson, L. J., Bohnsack, R. N., Kudo, M., Gotschall, R. R., Canfield, W. M., and Dahms, N. M. (2010) Man-P-GlcNAc Recognition by Domain 5 of the Cation-Independent Mannose 6-Phosphate Receptor. FASEB J. 24:lb106 |
41. Castonguay, A., Olson, L. J., Bohnsack, R. N., and Dahms, N. M. (2010) Characterization of the Carbohydrate Binding Properties of the Danio rerio Cation-Independent Mannose 6-Phosphate Receptor. Glycobiology 20, 1516, Abstract #207 |
42. LeBowitz, J.H., Maga, J.A., Zhou, J., Kambampati, R., Peng, S., Bohnsack, R. N.,Thomm, A., Golata, S., Tom, Pl, Dahms, N. M., and Byrne, B. J. (2010) Glycosylation-Independent Lysosomal Targeting of Acid alpha- Glucosidase Enhances Glycogen Clearance from Muscle Tissue of Pompe Mice. American Society of Human Genetics (60th Annual meeting, Nov 2, 2010, Washington DC) p. 599 Abstract #2047/T |
43. Dahms, N.M., Olson, L.J., Alculumbre, S.G., Stigliano, I.D., Peterson, F.C., Caramelo, J.J., Parodi, A.J., and D'Allesio, C. (2012) Structural and Functional Characterization of Glucosidase II N-glycan Binding Domains. FASEB J. 26, Abstract #796.1 |
44. Bord, M., Hermsen, C., Heur, W., Jones, C., Kennedy, E., Keslin, W., Khang, M., Leedom, H., LeMense, A., McMurray, D., Naber, E., Parish, D., Rice, M.E., Rodgers, A., Rosio, C., Schubert, J., Smith, A., Vogt, G., Linda Olson, L., and Dahms, N.M. (2012) Cation-Dependent Mannose 6-Phosphate Receptor: Tag, You're it! FASEB J. 26:lb250 |
45. Baldwin, A.C., Dahms, N.M., and Corbett, J.A. (2013) A Role for the Lysosome in Mediating beta-Cell Lipotoxicity. American Diabetes Association |
46. Orsi, R., Stigliano, I. D., Olson, L. J., Peterson, F. C., Alculumbre, S. G., Dahms, N. M., Parodi, A., and D’Alessio,C. (2013) From Sugars to Protein Folding in the Secretory Pathway: the Role of Glucosidase II Beta Subunit. Panamerican Association for Biochemistry and Molecular Biology (XII PABMB Congress, Nov 9-14, 2013 Puerto Varas, Chile)
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47. Dahms, N.M., Peterson, F.C., D'Allesio, C., Kim, J.-J. P., and Olson, L. J. (2013) Crystal Structural of Glucosidase II's Mannose 6-Phosphate Receptor Homology (MRH) Lectin Domain. Glycobiology 23, 1369, Abstract #114 |
48. Twining, S. S., Bohnsack, R. N., Warejcka, D. J., Gillespie, S. R., Bernstein, A. M., Dahms, N. M. (2014) Expression and Role of Insulin-like Growth Factor 2 Receptor (IGF2R) in the Cornea in Response to Wound Healing. Association for Research in Vision and Ophthalmology (ARVO) Abstract #4716
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49. Orsi, R., Stigliano, I. D., Olson, L. J., Peterson, F. C., Alculumbre, S. G., Dahms, N. M., Parodi, A., and D’Alessio,C. (2014) Glucosidase II: Quality Control from Glycoprotein Folding to the Structure of its Lectin MRH Domain. 1st Argentine Symposium on Glycobiology (Buenos Aires, Argentina)
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50. D'Alessio,C. (2014) Glucosidase II: Quality Control from Glycoprotein Folding to the Structure of its Lectin |
51. MRH Domain. 1st Argentine Symposium on Glycobiology (Buenos Aires, Argentina) |
52. Miller JJ, Aoki K, Tiemeyer M, Dahms NM. (2016) The α-galactosidase A-deficient rat: Characterization of a new animal model of Fabry disease. Mol Genet Metab.117(2):S81. |
53. Miller JJ, Aoki K, Murphy CA, Stucky CL, Kassem IS, Tiemeyer M, Dahms NM. (2017) The early stages of Fabry disease in an α-galactosidase A-deficient rat model. Mol Genet Metab.120(1-2):S97. |
54. Kassem IS, Miller JJ, Aoki K, Murphy CA, Young J, Tiemeyer M, Dahms, NM. (2017) Early ocular manifestations of Fabry disease in α-galactosidase A-deficient rats. Invest Ophthalmol Vis Sci. 58(8):5660. |
55. Bohnsack RN, Miller JJ, Twining SS, Olson LJ, Dahms NM. (2017) Cation-independent mannose 6- phosphate receptor interacts with several components of the plasminogen activation system. FASEB J. 31(1):Supplement 774.5. |
56. Miller JJ, Aoki K, Murphy CA, Stucky CL, Kassem IS, Tiemeyer M, Dahms NM. (2017) Glycolipid storage and phenotypes in a new rat model of Fabry disease. FASEB J. 31(1):Supplement 953.2. |
57. Zhu X, Yin L, Zhou J, Miller JJ, Siddiqui S, Theisen M, Levy B, Howell R, Presnyak V, Beltrame A, Murphy C, Frassetto A, Milano J, Lynn A, Besin G, Benenato K, Lukacs C, Dahms N, Guey L, Martini P. (2018) Systemic mRNA therapy for the treatment of Fabry disease: preclinical studies in Gla-deficient mice and rats, and wild-type non-human primates. Mol Genet Metab. 123(2):S153. |
58. Miller JJ, Moehring F, Aoki K, Tiemeyer M, Stucky CL, Dahms NM. (2018) Mechanical sensitization
indicates neuropathic allodynia in a rat model of Fabry disease. J Pain. |
59. Kassem IS, Miller JJ, Reid CA, Dahms NM. (2018) Ocular vascular manifestations of Fabry disease in
α- galactosidase A-deficient rats. Invest Ophthalmol Vis Sci. |
60. Miller JJ, Sokumbi O, North PE, Dahms NM. (2018) Fabry rat skin findings demonstrate potential roles
of inflammation and lipoatrophy in Fabry disease. J Invest Dermatol. |
Database, Video, or Other Research/Clinical Contributions |
1. Research Collaboratory for Structural Bioinformatics Protein Data Bank (RCSB PDB): |
2. 1M6P, CATION-DEPENDENT MANNOSE-6-PHOSPHATE RECEPTOR, 4-19-98, Roberts, D. L., Weix, D.J., Dahms, N.M., Kim, J.J. |
3. 1C39, STRUCTURE OF CATION-DEPENDENT MANNOSE 6-PHOSPHATE RECEPTOR BOUND TO PENTAMANNOSYL PHOSPHATE, 7-25-99, Olson, L.J., Zhang, J., Lee, Y.C., Dahms, N.M., Kim, J.J. |
4. 1KEO, TWISTS AND TURNS OF THE CD-MPR: LIGAND-BOUND VERSUS LIGAND-FREE RECEPTOR, 11-16-01, Olson, L.J., Zhang, J., Dahms, N.M., Kim, J.J. |
5. 2RL7, Crystal Structure cation-dependent mannose 6-phosphate receptor at pH 4.8, 10-18-07, Olson, L.J., Hindsgaul, O., Kim, J.-J.P., Dahms, N.M. |
6. 2RL8, Crystal Structure cation-dependent mannose 6-phosphate receptor at pH 6.5 bound to M6P, 10-18-07, Olson, L.J., Hindsgaul, O., Kim, J.-J.P., Dahms, N.M. |
7. 2RL9, Crystal Structure cation-dependent mannose 6-phosphate receptor at pH 6.5 bound to trimannoside, 10-18-07, Olson, L.J., Hindsgaul, O., Dahms, N.M., Kim, J.-J.P |
8. 2RLB, Crystal Structure cation-dependent mannose 6-phosphate receptor at pH 6.5 bound to M6P in absence of Mn, 10-18-07, Olson, L.J., Hindsgaul, O., Dahms, N.M., Kim, J.-J.P |
9. 3CY4, Crystal Structure cation-dependent mannose 6-phosphate receptor at pH 7.4, 4-25-08, Olson, L.J., Hindsgaul, O., Kim, J.-J.P., Dahms, N.M. |
10. 3K41, Crystal structure of sCD-MPR mutant E19Q/K137M bound to Man-6-P, 10-5-09, Olson, L.J., Sun, G., Bohnsack, R.N., Peterson, F.C., Dahms, N.M., Kim, J.J.P. |
11. 3K42, Crystal structure of sCD-MPR mutant E19Q/K137M pH 7.0, 10-5-09, Olson, L.J., Sun, G., Bohnsack, R.N., Peterson, F.C., Dahms, N.M., Kim, J.J.P. |
12. 3K43, Crystal structure of sCD-MPR mutant E19Q/K137M pH 6.5, 10-5-09, Olson, L.J., Sun, G., Bohnsack, R.N., Peterson, F.C., Dahms, N.M., Kim, J.J.P. |
13. 1Q25, Crystal structure of N-terminal 3 domains of CI-MPR, 7-23-03, Olson, L.J., Dahms, N.M., Kim, J.-J.P. |
14. 1SYO, N-terminal 3 domains of CI-MPR bound to mannose 6-phosphate, 4-1-04, Olson, L.J., Dahms, N.M., Kim, J.-J.P. |
15. 1SZO, N-terminal 3 domains of CI-MPR bound to mannose 6-phosphate, 4-1-04, Olson, L.J., Dahms, N.M., Kim, J.-J.P. |
16. 2KVA, SOLUTION STRUCTURE OF CI-MPR ligand-free domain 5, 10-3-10, Olson, L.J., Peterson, F.C., Volkman, B.F., Dahms, N.M. |
17. 2KVB, Solution structure of CI-MPR domain 5 bound to N-acetylglucosaminyl 6-phosphomethylmannoside, 10-3-10, Olson, L.J., Peterson, F.C., Volkman, B.F., Dahms, N.M. |
18. 2LVX, MRH domain of the Glucosidase II beta subunit from S. pombe, 7-12-12, Dahms, N.M., Olson, L.J., Peterson, F.C. |
19. 4XQM, crystal structure of MRH domain of the Glucosidase II beta subunit from S. pombe bound to mannose, 4-1-15, Dahms, N.M., Olson, L.J., Peterson, F.C. |
20. 2N1H, BMRB: 25560, W409A mutant of MRH domain of the Glucosidase II beta subunit from S. pombe, 4-1-15, Dahms, N.M., Olson, L.J., Peterson, F.C., Kim, J.-J. P. |