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CURRICULUM VITAE

Patricia A. Donohoue MD
Chief, Professor
Department of Pediatrics
Division of Endocrinology

OFFICE ADDRESS:
Children's Corporate Center
999 N 92 St
Milwaukee, WI 53226

EDUCATION:
1976 - Present B.S., cum laude, Marian College, Indianapolis
1980 - Present M.D., The Ohio State University, Columbus, Ohio

POSTGRADUATE TRAINING AND FELLOWSHIP APPOINTMENTS:
1980 - 1981 Pediatric Internship, Columbus Children's Hospital, The Ohio State University, Columbus, OH
1981 - 1983 Pediatric Residency, Rainbow Babies and Children's Hospital, Case Western Reserve University, Cleveland, OH
1983 - 1986 Pediatric Endocrinology Fellowship, Johns Hopkins University School of Medicine, Baltimore, MD
1986 Current Review of Pediatric Endocrinology, Serono Symposia and Lawson Wilkins Pediatric Endocrine Society, VA
1987 Short Course in Medical and Mammalian Experimental Genetics, The Jackson Laboratory and Johns Hopkins Genetics Department, Bar Harbor, ME
1993 Short Course in Medical and Mammalian Experimental Genetics, The Jackson Laboratory and Johns Hopkins Genetics Department, Bar Harbor, ME
1998 Expanding the Concept of Scholarship Through the Educator's Portfolio (2 hour seminar conducted by Deborah Simpson, Ph.D. Medical College of Wisconsin), University of Iowa College of Medicine, IA
1998 Senior Women in Medicine Professional Development Seminar, Association of American Medical Colleges, Washington, DC
1999 Cultural Competency in a Health Care Setting, Department of Pediatrics, University of Iowa, Iowa City, IA
1999 Faculty, Current Review of Pediatric Endocrinology, Serono Symposia and Lawson Wilkins Pediatric Endocrine Society, VA
2003 Faculty, Current Review of Pediatric Endocrinology, Serono Symposia and Lawson Wilkins Pediatric Endocrine Society, VA
2008 Leadership Development for Physicians in Academic Health Centers, Harvard School of Public Health, Boston, MA
2009 - 2010 Executive Leadership in Academic Medicine for Women (ELAM), Drexel University School of Medicine, PA

FACULTY APPOINTMENTS:
1986 - 1988 Instructor, Pediatrics, Johns Hopkins University School of Medicine, MD, Division of Endocrinology, Baltimore, MD
1988 - 1990 Assistant Professor, Division of Endocrinology, Pediatrics, Johns Hopkins University School of Medicine, Baltimore, MD
1990 - 1993 Assistant Professor, Pediatrics, The University of Iowa, College of Medicine, Division of Pediatric Endocrinology, Iowa City, IA
1993 - 2001 Associate Professor with Tenure, Pediatrics, The University of Iowa, College of Medicine, Division of Pediatric Endocrinology, Iowa City, IA
2001 - 2008 Professor with Tenure, Pediatrics, The University of Iowa,, Division of Pediatric Endocrinology and Diabetes, College of Medicine, Iowa City, IA
2006 - 2008 Endocrinology Consultant, Iowa Newborn Screening Program, IA
2008 - Present Professor with Tenure, Pediatrics, Section Chief, Medical College of Wisconsin, Division of Pediatric Endocrinology, Milwaukee, WI

EDUCATIONAL ADMINISTRATIVE APPOINTMENTS:
2006 - 2008 Program Director, Pediatric Endocrinology Fellowship Program, The University of Iowa, IA
2009 - 2010 Program Director, Pediatric Endocrinology Fellowship Program, Medical College of Wisconsin, WI

HOSPITAL AND CLINICAL ADMINISTRATIVE APPOINTMENTS:
Program Director, Endocrinology, Interim Program Director, Diabetes, Children's Hospital of Wisconsin, Milwaukee, WI

HOSPITAL STAFF PRIVILEGES:
Children's Hospital of Wisconsin, Milwaukee, WI

SPECIALTY BOARDS AND CERTIFICATION:
Board Certified
Issue DateExpiration
National Board of Medical Examiners
06/1980
None
American Board of Pediatrics
10/1985
None
American Board of Pediatrics, Pediatric Endocrinology
10/1986
None
 
Licensure
Number Issue DateExpiration
Iowa State Board of Medical Examiners
27642
06/26/1990
None
State of Wisconsin Department of Regulation and Licensing Permanent Medical License
51582-020
05/02/2008
None
 

AWARDS AND HONORS:
1999 - Present "Best Doctors in America", Woodward/White, Inc., Pediatric Specialists
2002 - Present "Donald A. Fleming Award for Distinguished Professional Achievement", Distinguished Alumni Award, Marian College, Indianapolis
2002 - 2011 "Best Doctors in America", Woodward/White, Inc., Pediatric Specialists

MEMBERSHIPS IN HONORARY AND PROFESSIONAL SOCIETIES:
1986 - Present American Association for the Advancement of Science
1987 - Present The Lawson Wilkins Pediatric Endocrine Society
1988 - Present The Endocrine Society
1990 - Present Fellow of the American Academy of Pediatrics
1991 - Present Midwest Pediatric Endocrine Society (President-Elect 2005-2007 President 2007-2009)
1991 - Present Midwest Society for Pediatric Research ((President-Elect 2005-2007 president 2000-2001)
1992 - 2011 Society for Pediatric Research (SPR)
1999 - Present The Lawson Wilkins Pediatric Endocrine Society (Liaison to the Endocrine Caucus of the AMA)
2000 - 2003 Society for Pediatric Research (SPR) Young Investigator Award selection committee(2002-03, chair)
2000 - 2003 Society for Pediatric Research (SPR) (Council)
2000 - 2002 The Lawson Wilkins Pediatric Endocrine Society (Organizer of "Career Guidance" seminars for fellows at PAS meetings)
2001 - 2002 The Lawson Wilkins Pediatric Endocrine Society (LWPES representative to International Congenital Adrenal Hyperplasia Consensus Group)
2003 - 2008 Iowa Medical Society
2004 - Present American Pediatric Society
2004 - 2005 The Lawson Wilkins Pediatric Endocrine Society (LWPES Co-director of International Intersex Consensus Group)

EDITORSHIPS/EDITORIAL BOARDS/JOURNAL REVIEWS:
Editorial Board
2001 - 2009 The Journal of Clinical Endocrinology & Metabolism
Journal Review
JAMA
Endocrinology
Molecular Endocrinology
The Journal of Clinical Investigation
Archives of Pediatric and Adolescent Medicine
Proceedings of the National Academy of Science, USA
Neuroendocrinology
Journal of Pediatrics
American Journal of Human Genetics
Human Molecular Genetics
American Journal of Physiology
Clinical Endocrinology
Human Genetics
Metabolism
Fertility and Sterility
Pediatrics
The Journal of Clinical Endocrinology & Metabolism

NATIONAL ELECTED/APPOINTED LEADERSHIP AND COMMITTEE POSITIONS:
1987 - Present The Lawson Wilkins Pediatric Endocrine Society
10/1993 Ad Hoc member, Program Project NICHD (NIH)
1993 - 1996 Membership Committee (1995-1996, Chair)The Lawson Wilkins Pediatric Endocrine Society
06/1994 Ad Hoc member, Revised Program Project for NICHD (NIH)
12/1994 Ad Hoc member, CRC Grant (NIH)
1995 - 2004 Abstract Reviewer, Midwest Society for Pediatric Research
1996 Outside Reviewer, Intramural grant proposal, University of Pittsburgh
1997 Invited Moderator, International Pediatric Endocrine Societies Meeting, guided poster session, Stockholm, Sweden
1997 - 2002 Chair, Midwest SPR platform presentation sessions, Chicago
1997 Outside Reviewer, College of Medicine Faculty Promotion, University of Pittsburgh
1998 Abstract Reviewer, VA Merit Research Grant Proposal, University of Iowa
1998 - 2003 Abstract Reviewer, Society for Pediatric Research3
1998 - 2002 Liaison to the Program Committee of the PAS, The Lawson Wilkins Pediatric Endocrine Society
1998 - 2002 Program Committee (2001-2002, Chair), The Lawson Wilkins Pediatric Endocrine Society
1999 Moderator, State of the Art Plenary Session on Childhood Obesity, Pediatric Academic Societies meeting, San Francisco
1999 - 2008 Abstract Reviewer, Clinical Research Center protocol proposals, Univ.of Iowa
1999 Outside reviewer, Israel Science Foundation research grant proposal
2001 Abstract Reviewer, International Pediatric Endocrine Societies
2001 - 2005 Ad Hoc Committee on Intersex, The Lawson Wilkins Pediatric Endocrine Society
2001 Moderator, Minicourse on Childhood Diabetes, Pediatric Academic Societies Meeting, Baltimore
06/2002 Ad Hoc member, Department of Pediatrics CHRC grants
2002 Moderator, Platform Presentations, Pediatric Academic Societies Meeting, Baltimore
2002 Moderator, Platform Presentations, The Endocrine Society Meeting, San Francisco
08/2004 Ad Hoc member, NICHD RFA (NIH)
2004 Chair, Basic Science Symposium, The Endocrine Society Meeting, New Orleans
04/2005 Ad Hoc member, NIH loan repayment award applications (NIH)
07/2005 Ad Hoc member, NIH Special emphasis panel for U13 awards (NIH)
2005 Co-Leader, Educational Workshop on 2-career couples, The Pediatric Academic Societies meeting, Washington DC
2006 Outside Reviewer, College of Medicine Division Director appointment, OSU
2007 - 2010 Ad Hoc Committee on DSD (intersex) (Chair), The Lawson Wilkins Pediatric Endocrine Society
01/2008 Ad Hoc member, study secition, NRSA T32 awards (AHRQ)
2008 Chair, Topic Symposium on Gender Medicine, The Pediatric Academic Societies meeting, Honolulu
2010 Outside Reviewer, College of Medicine Faculty Promotion, Indiana University
2011 - Present Member, education council, The Lawson Wilkins Pediatric Endocrine Society

RESEARCH GRANTS/AWARDS/CONTRACTS/PROJECTS:
Prior
Peer Review
Source:
NIH Clinical Associate Physician (CAP) Award
Dates:
1987 - 1989
 
Title:
"21-Hydroxylase Deficiency: Mutations and Mechanisms
Source:
NIH R29 DK41260
Role:
Principal Investigator
Dates:
1989 - 1995
 
Title:
"Genetic determination of human obesity"
Source:
Carver Trust Medical Research Initiative
Role:
Principal Investigator
Dates:
04/01/1992 - 03/31/1993
Direct Funds:
$8,000
 
Title:
"The genetic epidemiology of childhood obesity"
Source:
NIH R01 HD29569
Role:
Co-Principal Investigator
PI:
Trudy L. Burns
Dates:
1992 - 2006
 
Non-Peer Review
Title:
"21-Hydroxylase Deficiency, Mutations and Mechanisms"
Source:
Children's Miracle Network
Dates:
07/1991
Direct Funds:
$7,500
 
Title:
"Molecular Causes of Salt-Losing Congenital Adrenal Hyperplasia"
Source:
Children's Miracle Network
Dates:
07/1992
Direct Funds:
$4,000
 
Title:
"The effect of recombinant growth hormone treatment in poorly growing patients receiving pharmacologic corticosteroid therapy"
Source:
Genentech Corporation
Role:
Principal Investigator
Dates:
1993 - 1997
 
Title:
"Studies of the control of Gene Expression Using the Luciferase Reporter Gene"
Source:
Children's Miracle Network
Dates:
03/1994
Direct Funds:
$9,000 (funds for purchase of shared equipment for Department of Pediatrics)
 
Title:
"Genetic Epidemiology of Childhood Obesity"
Source:
Children's Miracle Network
Dates:
03/1994
Direct Funds:
$7,050
 
Title:
21-Hydroxylase Deficiency, Mutations and Mechanisms"
Source:
Children's Miracle Network
Dates:
06/1996
Direct Funds:
$7,500
 
Title:
"Physical activity, diet, and genetic factors in women: a cross-sectional study"
Source:
Muscatine Health Support Foundation
Role:
genotyping
PI:
Kathy Janz, PhD
Dates:
1996 - 1999
 
Title:
"Genetics of Human Obesity"
Source:
Children's Miracle Network
Dates:
01/1997
Direct Funds:
$7,500
 
Title:
“Analysis of gene expression in adipose tissues of morbidly obese individuals”
Source:
Children's Miracle Network
Dates:
11/05/1998 - 11/05/2000
Direct Funds:
$7,500
 
Source:
KIGS (Pfizer International Growth Study)
Role:
Univ. of Iowa Local PI
Dates:
2000 - 2008
 
Title:
“GH treatment in patients born SGA”
Source:
Pfizer
Role:
Local PI
Dates:
2002 - 2004
 
Title:
multicenter collaborative randomized placebo-controlled trial of octreotide in hypothalamic obesity
Source:
Novartis
Role:
Co-Investigator
PI:
Thomas Loew, MD
Dates:
2003 - 2005
 
Title:
Multicenter collaborative randomized open trial of growth hormone in patients with cystic fibrosis
Source:
Genentech
Role:
consultant
PI:
Richard Ahrens, MD
Dates:
2004 - 2006
 
Title:
4-Year Open-Label Multi-Center Randomized 2-Arm Study of Genotropin in Idiopathic Short Stature Patients:Comparing Individualized Target-Driven Treatment Regimen to Standard Dosing of Genotropin
Source:
Pfizer
Role:
Local PI
Dates:
2007 - 2008
 

INVITED LECTURES/WORKSHOPS/PRESENTATIONS:
Local
The Genetics and Endocrinology of Obesity: Can We Take This Stuff to the Clinic?, Children's Hospital of Milwaukee, 2006 - Present
Max McGee Center research seminar: genetics and epidemiology of obesity, Medical College of Wisconsin, 01/2011 - Present
 
Regional
Statewide Perinatal Care, Ambiguous Genitalia Program, Des Moines, IA, 1991 - Present
Broadlawns Family Practice, Precocious Puberty Center, Des Moines, IA, 1992 - Present
Broadlawns Family Practice, Thyroid Disease Center, Des Moines, IA, 1995 - Present
St. Luke's Hospital Family Practice Lecture Series, Rickets, Iowa City,IA, 1996 - Present
St. Luke's Hospital Family Practice Lecture Series, Ambiguous Genitalia, Cedar Rapids, IA, 1997 - Present
Great Plains Regional Genetics Conference, Genetics of Obesity, Iowa City, IA, 1998 - Present
The Genetics of Obesity: Of Mice and Men and Women, The Midwest Pediatric Endocrine Society, Chicago, IL, 1999 - Present
Center for Disabilities and Development, Gender Identification and Orientation, Iowa City, IA, 2002 - Present
Lecture for Pediatricians, Iowa City Use of Growth Hormone in SGA Children, 2005 - Present
Community Seminar sponsored by CHI, Childhood Obesity: What can we do?, 2006 - Present
Childhood Obesity, Nursing CEU Course, Children's Hospital of Iowa, 2007 - Present
Pediatric Grand Rounds, Thyroid Conditions in Childhood, Grayslake, IL, 2008 - Present
Endocrinology Practice, Congenital Adrenal Hyperplasia in Adults, Menomenee Falls, WI, 2009 - Present
Pediatric Critical Care Conf., Steroid Dosing in the ICU, 2010 - Present
Pediatric Grand Rounds, Adrenal function in the critically ill, 2010 - Present
 
National
Adrenocortical Cytochrome P450s, Endocrinology Grand Rounds, Johns Hopkins University, 1986 - Present
Congenital Adrenal Hyperplasia, Pediatric Grand Rounds, Johns Hopkins University, 1987 - Present
Research Conference, Congenital Adrenal Hyperplasia, University of Maryland, Baltimore, MD, 1988 - Present
Puberty, Pediatric Trends(Postgrad. Course), Johns Hopkins University, 1988 - Present
Thyroid Function Tests, Pediatric Trends, Johns Hopkins University, 1989 - Present
Congenital Adrenal Hyperplasia, Endocrinology Association of Tampa, FL, 1989 - Present
Congenital Adrenal Hyperplasia, Endocrinology Grand Rounds, Johns Hopkins University, 1989 - Present
21-Hydroxylase Gene Mutations in Congenital Adrenal Hyperplasia, Endocrinology and Metabolism Research Seminar, Johns Hopkins University, 1990 - Present
The CYP21 Promoter, The International Congenital Adrenal Hyperplasia Symposium, Baltimore, MD, 1995 - Present
Genetics of Obesity in Muscatine, IA (* International Life Sciences Institute), ILSI* Children and Adolescent Obesity Workshop, Atlanta, GA, 1995 - Present
Visiting Professor, 3 lectures :Congenital Adrenal Hyperplasia; Gene defects in Patients with Pituitary Hormone Deficiencies; Obesity, The Medical College of Georgia, Augusta, GA, 1995 - Present
Genetic Epidemiology of Childhood Obesity: The Muscatine Study, Univ. of Alabama, Birmingham, AL, 1998 - Present
International Symposium on a Current Review of Pediatric Ebdocrinology: Congenital Adrenal Hyperplasia, Serono Symposium, San Francisco, CA, 1999 - Present
Workshop on Obesity in Pediatrics, Johns Hopkins University: Pediatric Endocrinology for Primary-Care Clinician, 2000 - Present
Meet the Professor Sessions (2) Congenital Adrenal Hyperplasia, The Endocrine Society Meeting, 2003 - Present
Report on Intersex Team Survey, PAS/LWPES meeting, 2003 - Present
International Symposium on a Current Review of Pediatric Endocrinology: Congenital Adrenal Hyperplasia, Serono Symposium, Seattle, WA, 2003 - Present
Topic Symposium: Role or No Role for prenatal diagnosis and testing in CAH, PAS/LWPES meeting, 2006 - Present
The Genetics and Endocrinology of Obesity: Can We Take This Stuff to the Clinic?, Cincinnati Children's Hospital, 2006 - Present
Adrenal Function in Critically Ill, Pediatric Grand Rounds, University of Missouri, Columbia, 2007 - Present
 

COMMITTEE SERVICE:
Medical College
1993 - Present Resident Evaluation Committee, Department of Pediatrics, University of Iowa
1994 LCME Subcommittee on Research (IX) for the Institutional Task Force, University of Iowa College of Medicine
1995 - 2004 Research and Fellowship Committee, Department of Pediatrics, University of Iowa
1996 - 2002 Ad Hoc Interviewer for Internship Applicants, Department of Pediatrics, University of Iowa
1996 - 2001 Coordinator: Department of Pediatrics Faculty Research Seminar Series, Department of Pediatrics, University of Iowa
1996 - 2005 Interviewer: Medical School Applicants, University of Iowa College of Medicine
1997 - 1999 Chair, Search Committee, Pediatric Hematology/Oncology Division Director, Department of Pediatrics, University of Iowa
1998 - 2005 Radioactive Drug Research Committee, University of Iowa
1998 - 2005 Hospital Radiation Safety Review Group, University of Iowa
1998 - 2005 Medical Radiation Protection Committee, University of Iowa
1998 - 2003 Committee on Conflict of Interest in Research, University of Iowa
1999 - Present Director, Gender Issues Management (GIM) Team, Department of Pediatrics, University of Iowa
1999 - Present Poster reviewer and judge, annual COM research week, University of Iowa College of Medicine
2000 - 2001 Search Committee for Director of the Clinical Research Center, University of Iowa College of Medicine
2000 - 2001 Search Committee for Pediatric Faculty Member in Division of Medical Genetics, Department of Pediatrics, University of Iowa
2000 - 2001 Clinician Scientist subcommittee of the Patient and Population-based Research Retreat Committee, University of Iowa College of Medicine
2000 - 2003 Chair, Committee on Conflict of Interest in Research, University of Iowa
2001 LCME Subcommittee on Research (IX) for the Institutional Task Force, University of Iowa College of Medicine
2001 - 2002 Strategic Plan Revision Committee, co-chair with Paul McCray, MD, Department of Pediatrics, University of Iowa
2001 VP for Research Task force on Conflict of Interest, University of Iowa
2003 - 2005 Search Committee for Pediatric Faculty Member in Division of Neonatology, Department of Pediatrics, University of Iowa
2003 Department of Dermatology Review Committee, University of Iowa College of Medicine
2004 - 2008 Pediatrics Faculty Promotions Advisory Committee, Department of Pediatrics, University of Iowa
2004 - 2006 Search Committee for Chair, Department of Dermatology, University of Iowa College of Medicine
2005 - 2007 Selection Committee, Earnest O. Thielen Teaching Award, University of Iowa College of Medicine
2006 - 2008 Endocrinology Consultant, state of Iowa Newborn Screening Program, Department of Pediatrics, University of Iowa
2006 - 2008 Subspecialty Training Oversight Committee, Department of Pediatrics, University of Iowa
2006 - 2008 Pediatrics Faculty Contact for MSTP Clinical Connections Program, University of Iowa College of Medicine
2006 - 2008 Program Director, Pediatric Endocrinology Fellowship Program, Department of Pediatrics, University of Iowa
Member, Internal Advisory Committee for the Children's Environmental Health Center, Medical College of Wisconsin
 
Hospital
2008 - 2010 Ambulatory Electronic Health Record Task Force, Children's Hospital of Wisconsin
 

MEDICAL COLLEGE TEACHING ACTIVITIES:
Medical Student Education
Section weekly academic conferences (several times annually)
 
Resident and Fellow Education
1997 - 2007 University of Iowa, Pediatric Residents: Orientation/Emergency Lecture Series - 1-2 lectures per year; Core Lecture Series - 4 lectures per 18 month cycle
2008 - Present Fellows lectures (every 10 months) 1. Steroid review/Adrenal insufficiency 2. Congenital adrenal hypserplasia
University of Iowa, Development and Periodic Revision of Pediatric Endocrinology Curriculum/Objectives and Reading Materials for the Pediatric Resident Elective
Fellowship program core curriculum (6 week block on adrenal function and pathology repeats every 10 months)
 

EXTRAMURAL TEACHING:
Medical Student Education
1990 - Present University of Iowa, Medical Students (M3 and M4) during pediatric clerkship, rotating on inpatient unit; teaching rounds up to 1 hour weekly during 4 months per year as Pediatric Endocrinology Attending on Service
1995 - 2001 University of Iowa, Summer course in human genetics (undergraduate research program of Dr. Jeff Murray); one lecture per summer; topic: "Genetics of Obesity"
2001 - 2008 University of Iowa, Program Committee member for the T32 Training Program in Neonatal Biology
 
Continuing Medical Education
09/1990 University of Iowa, Faculty Research Seminar, 21-hydroxylase gene mutations In Congenital Adrenal Hyperplasia
1990 Pediatric Postgrad. Course, Congenital Adrenal Hyperplasia
04/1991 University of Iowa, Endo. & Metab. Conference Ambiguous Genitalia
09/1991 University of Iowa, Endo. & Metab. Conference, Congenital Adrenal Hyperplasia
02/1992 University of Iowa, Ped. Residents Conference, Thyroid Function
03/1992 University of Iowa, Ped. Faculty Research Conf. Molecular genetics of Steroid 21-hydroxylase
03/1992 University of Iowa, Endo. & Metab. Conference Pituitary Gigantism
12/1992 University of Iowa, Endo. & Metab. Conference Genetic Mutations which Produce Deficiencies of Pituitary Hormones
06/1993 University of Iowa, Endo. & Metab. Conference The 11-Hydroxylase gene: more than meets the eye
05/1994 University of Iowa, Pediatrics Workshop, Gene Promoter Analysis
05/1994 University of Iowa, Pediatrics Workshop, Gene Promoter Analysis
06/1994 University of Iowa, Endo. & Metab. Conference, Molecular Biology of Sexual Differentiation
06/1994 University of Iowa, Endo. & Metab. Conference Molecular Biology of Sexual Differentiation
11/1994 University of Iowa, Endo. & Metab. Conference, Peroxisomal Disorders
11/1994 University of Iowa, Pediatric Grand Rounds, Congenital Adrenal Hyperplasia
11/1994 University of Iowa, Endo. & Metab. Conference, Peroxisomal Disorders
11/1994 University of Iowa, Pediatric Grand Rounds, Congenital Adrenal Hyperplasia
06/1995 University of Iowa, Endo. & Metab. Conference, 21-Hydroxylase Promoter Studies
06/1995 University of Iowa, Endo. & Metab. Conference, 21-Hydroxylase Promoter Studies
12/1995 University of Iowa, Endo. & Metab. Conference, The beta3 Adrenergic Receptor
12/1995 University of Iowa, Endo. & Metab. Conference, The beta3 Adrenergic Receptor
01/1996 University of Iowa, Pediatric Grand Rounds, Obesity
01/1996 University of Iowa, Pediatric Grand Rounds, Obesity
06/1996 University of Iowa, Endo. & Metab. Conference, Drug Therapy in Obesity
06/1996 University of Iowa, Endo. & Metab. Conference, Drug Therapy in Obesity
08/1996 University of Iowa, Cooperative Human Obesity: Rodents and Humans Linkage Center
08/1996 University of Iowa, Cooperative Human Linkage Center Obesity: Rodents and Humans
11/1996 University of Iowa, Endo. & Metab. Conference, Growth Hormone Therapy in Adults
11/1996 University of Iowa, Department of Pediatrics Research Day Genetic Studies in Human Obesity
11/1996 University of Iowa, Endo. & Metab. Conference Growth Hormone Therapy in Adults
11/1996 University of Iowa, Department of Pediatrics Research Day Genetic Studies in Human Obesity
04/1997 University of Iowa, Endo. & Metab. Conference Rodent Obesity Mutations and Their Human Homologs
04/1997 University of Iowa, Endo. & Metab. Conference, Rodent Obesity Mutations and Their Human Homologs
05/1997 University of Iowa, M2 ICM Course, Newborn Screening Tests
05/1997 University of Iowa, M2 ICM Course, Newborn Screening Tests
06/1997 University of Iowa, Cooperative Human Linkage Center Obesity: Rodents and Humans
06/1997 University of Iowa, Cooperative Human Obesity: Rodents and Humans Linkage Center
10/1997 University of Iowa, Endo. & Metab. Conference Peroxisome Proliferator Activator Receptors (PPARs)
10/1997 University of Iowa, Endo. & Metab. Conference Peroxisome Proliferator Activator Receptors (PPARs)
10/1997 University of Iowa, Faculty Research Seminar, Update on the Genetics of Obesity:Rodents and Humans
10/1997 University of Iowa, Faculty Research Seminar, Update on the Genetics of Obesity:Rodents and Humans
11/1997 University of Iowa, M1 Basic Science Human Genetics Course Complex Traits: Genetics of Obesity and Diabetes
11/1997 University of Iowa, M1 Basic Science Human Genetics Course Complex Traits: Genetics of Obesity and Diabetes
1997 Pediatric Postgrad. Course, Obesity: Of Mice and Men (and Women)
02/1998 University of Iowa, Pediatric Resident Conf. Ambiguous Genitalia
03/1998 University of Iowa, Endo. & Metab. Conference Orlistat for Obesity Therapy
03/1998 University of Iowa, Endo. & Metab. Conference, Orlistat for Obesity Therapy
04/1998 University of Iowa, M2 ICM Course Newborn Screening Tests
07/1998 University of Iowa, Pediatric Resident Conf., Thyroid Storm and Adrenal Crisis
12/1998 University of Iowa, Pediatric Resident Conf., Ambiguous Genitalia
12/1998 University of Iowa, Endo. & Metab. Conference, Leptin in Fetal Life, Childhood, and Puberty
03/1999 University of Iowa, Pediatric Resident Conf., Thyroid Function and Thyroid Disease
07/1999 University of Iowa, Pediatric Resident Conf., Thyroid Storm and Adrenal Crisis
09/1999 University of Iowa, Pediatric Resident Conf., Ambiguous Genitalia
10/1999 University of Iowa, Endo. & Metab. Conference, Procalcitonin and Sepsis
11/1999 University of Iowa Pediatric Resident Conf., The Thyroid Gland
04/2000 University of Iowa, M2 ICM Course, Newborn Screening Tests
04/2000 University of Iowa, Endo. & Metab. Conference, Hypothalamic Obesity
07/2000 University of Iowa, Pediatric Resident Conf., Thyroid Storm and Adrenal Crisis
09/2000 University of Iowa, Endo. & Metab. Conference, The HPA Axis and Obesity
02/2001 University of Iowa, Endo. & Metab. Conference, New Approach to Gene Rx in Type 1 Diabetes Mellitus
03/2001 University of Iowa, Pediatric Resident Conf., Ambiguous Genitalia
04/2001 University of Iowa, Pediatric Resident Conf., Thyroid Diseases
04/2001 University of Iowa, Pediatric Resident Conf., Obesity
07/2001 University of Iowa, Pediatric Resident Conf., Thyroid Storm and Adrenal Crisis
08/2001 University of Iowa, Endo. & Metab. Conference, Nonprescription Weight Loss Products: What are They?
11/2001 University of Iowa, Pediatric Grand Rounds, Genetic Control of Sexual Differentiation
11/2001 University of Iowa, Pediatric Resident Conf., Ambiguous Genitalia
02/2002 University of Iowa, Endo. & Metab. Conference, Genetic Control of Sexual Differentiation
04/2002 University of Iowa, Pediatric Resident Conf., Metabolic Bone Disease
07/2002 University of Iowa, Pediatric Resident Conf., Adrenal Crisis and Thyroid storm Steroid review
10/2002 University of Iowa, Endo. & Metab. Conference, Ghrelin
12/2002 University of Iowa, Pediatric Resident Conf., Thyroid Disorders in Children
01/2003 University of Iowa, Endo. & Metab. Conference, DiGeorge Syndrome
01/2003 University of Iowa, Pediatric Resident Conf., Obesity in Children and Adolescent
02/2003 - 2003 University of Iowa, Ob/Gyn Grand Rounds, Precocious Puberty in Girls
05/2003 University of Iowa, Pediatrics Research Day, Novel MC4-R Deletion in Obese Human
07/2003 University of Iowa, Pediatric Resident Conf., Adrenal Crisis and Thyroid storm Steroid review
09/2003 University of Iowa, Endo. & Metab. Conference, Adiponectin
09/2003 University of Iowa, Pediatric Resident Conf., Ambiguous Genitalia
10/2003 University of Iowa, Pediatric Resident Conf., Metabolic Bone Disease
2003 Pediatrics Postgraduate Course, Control of Energy Homeostasis Precocious Puberty
02/2004 University of Iowa, Pediatric Grand Rounds, Consensus Statement on CAH
04/2004 University of Iowa, Endo. & Metab. Conference TPIT mutations in ACTH deficiency
07/2004 University of Iowa, Pediatric Resident Conf., Adrenal Crisis and Thyroid storm Steroid review
09/2004 University of Iowa, Pediatric Resident Conf., Obesity
03/2005 University of Iowa, Pediatric Resident Conf., Ambiguous Genitalia
03/2005 University of Iowa, Pediatric Resident Conf., Metabolic Bone Disease
05/2005 University of Iowa, Societal Professional Ethics conf., Consultation regarding ambiguous gender
07/2005 University of Iowa, Pediatric Resident Conf., Adrenal Steroid review/ adrenal crisis
08/2005 University of Iowa, Endo. & Metab Conf., Adiponectin, Leptin, and Insulin in the Muscatine Family Study
01/2006 University of Iowa, Pediatric Resident Conf., Thyroid disorders
01/2006 University of Iowa, Pediatric Resident Conf., Obesity
02/2006 - 03/2006 University of Iowa, Neonatology Fellows lectures 3 part series of one hour lectures on endocrinology perinatal/neonatal
02/2006 University of Iowa, Pediatric Grand Rounds, New indications for GH Therapy
03/2006 University of Iowa, Endo. & Metab Conf., Obestatin and Ghrelin
07/2006 University of Iowa, Pediatric Resident Conf., Adrenal Insufficiency and Steroid Review
09/2006 University of Iowa, Pediatric Resident Conf., Ambiguous Genitalia
10/2006 University of Iowa, Pediatric Resident Conf., Metabolic Bone Disease
07/2007 University of Iowa, Pediatric Resident Conf., Adrenal Insufficiency and Steroid Review
08/2007 University of Iowa, Endo. & Metab Conf, Prader Willi Syndrome: Care of the Adult Patient
09/2007 University of Iowa, Combined endocrine fellowships, Molecular Biology Techniques Introductory lecture series
 

MCW STUDENTS, FACULTY, RESIDENTS AND CLINICAL/RESEARCH FELLOWS MENTORED:
Clinical/Research Fellows
Katie Marquart, MD, Medical College of Wisconsin, supervised for clinical training
Moina Uddin, DO, Medical College of Wisconsin, supervised for clinical training
Aashima Bansal, MD, Medical College of Wisconsin, supervised for clinical training
Bhavana Narala, MD, Medical College of Wisconsin, supervised for clinical training
Samuel Engle, DO, Medical College of Wisconsin, supervised for clinical training
Ornsuda Lertbannaphong, MD, Medical College of Wisconsin, Supervised for clinical training
Himala Kashmiri DO, Medical College of Wisconsin, supervised for clinical training
Laura Levin DO, Medical College of Wisconsin, supervised for clinical training
Rita Shridharani MD, Medical College of Wisconsin, supervised for clinical training
Ola Kawadry DO, Medical College of Wisconsin, supervised for clinical training
Priya Khanna MD, Medical College of Wisconsin, supervised for clinical training
MaryKathleen Heneghan MD, Medical College of Wisconsin, supervised for clinical training
Hanaa Zidan MD, Medical College of Wisconsin, supervised for clinical training
Alison Coren, MD, Medical College of Wisconsin, supervised for clinical training
 

EXTRAMURAL STUDENTS, FACULTY, RESIDENTS, AND CLINICAL/RESEARCH FELLOWS MENTORED:
Undergraduate Students
Therese Gannon, University of Iowa, 1995 Summer Research Program
Adam Bjork, St. Olaf College, 1996 Summer Research Program
Bethany Helms, Harvard University, 1997 Summer Research Program
Abby Green, Tufts University, 1999 Summer Research Program
Therese Nguyen Hornbeck, Des Moines Medical University, 1999 - 2000 Summer Research Program
Rebecca Franz, Luther College, 2000 - 2002 Summer Research Program
Joshua Myatt, University of Wisconsin, 2001 - 2002 Summer Research Program
 
Medical Students
Stephanie L. Brown, University of Iowa, 1994 - 1995 Summer Research Program
Lauren Doughty, University of Iowa, 2000 Summer Research Program
Marjory Charlot, University of Iowa, 2001 Summer Research Program
Justin Pattee, University of Iowa, 2003 Summer Research Program
 
Graduate Students
PhD Committees
Hsiao-Mei Wang, University of Iowa, 1995
 
Clinical/Research Fellows
Nicholas Jospe, M.D, Johns Hopkins University, 1985 - 1988 supervised directly in laboratory or clinical research projects
Ying Tai Chang MD, Johns Hopkins University, 1986 - 1990 supervised for clinical training
Rose Mulaikal MD, Johns Hopkins University, 1986 - 1990 supervised for clinical training
Tarek Bisat MD, Johns Hopkins University, 1986 - 1990 supervised for clinical training
Emily Germain-Lee MD, Johns Hopkins University, 1986 - 1990 supervised for clinical training
Patricia Fechner MD, Johns Hopkins University, 1986 - 1990 supervised for clinical training
Barry Reiner MD, Johns Hopkins University, 1986 - 1990 supervised for clinical training
Sigrid Gelber MD, Johns Hopkins University, 1986 - 1990 supervised for clinical training
Romolo Sandrini-Neto, M.D., Johns Hopkins University, 1986 - 1988 supervised directly in laboratory or clinical research projects
Jennifer H. Kyllo, M.D., University of Iowa, 1991 - 1996 supervised directly in laboratory or clinical research projects
Maureen Morgan, M.D., University of Iowa, 1993 - 1995 supervised directly in laboratory or clinical research projects
Sivaj U. Siddiqi MD, University of Iowa, 1998 - 1999 supervised directly in laboratory or clinical research projects
Michael Tansey, M.D., University of Iowa, 1998 - 2001 supervised directly in laboratory or clinical research projects
Eray Savgan Gurol MD, University of Iowa, supervised for clinical training
Rinku Mehra MD, University of Iowa, supervised for clinical training
Laudy Naimeh MD, University of Iowa, supervised for clinical training
Jennifer Kyllo MD, University of Iowa, supervised for clinical training
Jennifer Cook MD, University of Iowa, supervised for clinical training
Peter Gerrits MD, University of Iowa, supervised for clinical training
Michael Tansey MD, University of Iowa, supervised for clinical training
 

PROGRAMMATIC DEVELOPMENTS:
 
 
Clinical Programs
Pediatric Endocrinology and Diabetes clinics (3-4 half days/week); additional ½ day/week in obtaining/communicating results and completing documentation.
Pediatric Endocrinology outpatient call (2.5 months/year): phone consultations from referring providers, review of all endocrine new patient referrals (25-35/week)
Pediatric Endocrinology inpatient service (2.5 months/year); inpatient rounds, inpatient and outpatient consults, 24/7 hour on call by phone.
 
 


BIBLIOGRAPHY
Refereed Journal Publications/Original Papers
1. Donohoue P.A., Van Dop C., McLean R.H., White P.C., Jospe N., Migeon C.J.: Gene conversion in salt-losing congenital adrenal hyperplasia with absent complement C4B protein. J. Clin. Endocrinol. Metab. 62:995-1002, 1986.
2. Donohoue P.A., Jospe N., Migeon C.J., McLean R.H., Bias W.B., White P.C., Van Dop C.: Restriction maps and restriction fragment length polymorphisms of the human 21-hydroxylase genes. Biochem. Biophys. Res. Commun. 136:722-729, 1986.
3. Jospe N., Donohoue P.A., Van Dop C., McLean R.H., Bias W.B., Migeon C.J.: Prevalence of polymorphic 21-hydroxylase gene (CA21HB) mutation in salt-losing congenital adrenal hyperplasia. Biochem. Biophys. Res. Commun. 142:798-804, 1987.
4. Donohoue P.A., Van Dop C., Migeon C.J., McLean R.H., Bias W.B.: Coupling of HLA A3,Cw6,Bw47,DR7 and a normal CA21HB steroid 21-hydroxylasegene in the Old Order Amish. J. Clin. Endocrinol. Metab. 65:980-986, 1987.
5. McLean R.H. Donohoue P.A., Jospe N., Bias W.B., Van Dop C., Migeon C.J.: Restriction fragment analysis of duplication of the fourth component of complement (C4A). Genomics 2:;76-85, 1988.
6. Reiner B.J., Donohoue P.A., Migeon C.J. Berkovitz G.D.: The role of serum 3a-androstanediol glucuronide measurements in sexually mature women with congenital adrenal hyperplasia during therapy. J. Clin. Endocrinol. Metab. 69:105-109, 1989.
7. Donohoue, P.A., Jospe N., Migeon C.J., Van Dop C.: Two distinct areas of unequal crossingover within the steroid 21-hydroxylase genes produce absence of CYP21B. Genomics 5:397-406, 1989.
8. Van Dop C., Donohoue P.A., Bock G.H., Ruley J.: Enhanced growth with growth hormone therapy after renal transplantation. Pediatric Nephrology 3:468-469, 1989.
9. Gearhart J.P., Donohoue P.A., Brown T.R., Walsh P.C., Berkovitz G.D.: Endocrine evaluation of adults with mild hypospadias. J. of Urology 144:274-279, 1990.
10. Donohoue P.A., Sandrini-Neto, R., Collins M.M., Migeon C.J.: Exon 7 NcoI restriction site within CYP21B (steroid 21-hydroxylase) is a normal polymorphism. Molecular Endocrinology 4:1354-1362, 1990.
11. Van Dop C., Donohoue P.A., Jabs K.L., Bock G.H., Fivush B.A., Harmon W.E.: Glucose tolerance in children with renal allografts and the effect of growth hormone treatment. J. Pediatr., 118:708-714, 1991.
12. Van Dop C., Jabs K.L., Donohoue P.A., Bock G.H., Fivush B.A., Harmon W.E.: Accelerated growth rates during growth hormone treatment of children who grow poorly following renal transplantation. J. Pediatr., 120:244-250, 1992.
13. Gelber S.J., Heffez D., Donohoue P.A.: Pituitary gigantism due to growth hormone excess since infancy. J. Pediatr. 120:931-934, 1992.
14. Donohoue P.A. and Collins M.M.: The human complement C4B/steroid 21-hydroxylase (CYP21) and complement C4A/21-hydroxylase pseudogene (CYP21P) intergenic sequences: comparison and identification of possible regulatory elements. Biochem. Biophys. Res. Commun. 186:256-262, 1992.
15. Jabs K., Van Dop C., Donohoue P.A., Bock G.H., Fivush B.A.: Cadaveric renal allograft rejection after treatment with recombinant human growth hormone. J. Pediatr. (letter), 121:665, 1992.
16. Kyllo J.H., Kirby-Keyser L., Donohoue P.A., Porter C.C.: A new way to seal glass plates for denaturing gradient gel electrophoresis. BioTechniques 16:792,1994.
17. Donohoue P.A., Guethlein L., Collins M.M., Van Dop C., Migeon C.J., Bias W.B., Schmeckpeper B.J.: The HLA-A3, Cw6, Bw47, DR7 extended haplotypes in salt losing 21-hydroxylase deficiency and in the Old Order Amish: Identical MHC class I antigens and class II alleles with at least two crossover sites in the class III region. Tissue Antigens 46:163-172, 1995.
18. Kyllo J.H., Collins M.M., Donohoue P.A.: Constitutive human steroid 21-hydroxylase promoter activity in nonsteroidogenic cells as assessed with the luciferase gene as a reporter. Endocrine Research 21:777-791, 1995.
19. Kyllo J.H., Collins M.M., Vetter K.L., Cuttler L., Rosenfield R.L., Donohoue P.A.: Linkage of congenital isolated adrenocorticotropin hormone deficiency to the corticotropin releasing hormone locus using simple sequence repeat polymorphisms. Am. J. Med. Genet., 62:262-267, 1996.
20. Sivitz W.I., Bailey H.L., Donohoue P.A.: Rat adipose ob mRNA levels in states of altered circulating glucose and insulin. Biochem. Biophys. Res. Commun. 220:520-525, 1996.
21. Shin M.Y., Hoffman W.H., Donohoue P.A., Helman S.W., Brown S.L., Rosculet G., Mahesh V.B.: Phenotypic evolution of classic 21-hydroxylase deficiency. Clinical Endocrinology 45:103-109, 1996.
22. Kirby-Keyser L., Porter C., Donohoue P.A.: E380D: A novel point mutation of CYP21 in an HLA-homozygous patient with salt-losing congenital adrenal hyperplasia due to 21-hydroxylase deficiency. Human Mutation, 9:181-182, 1997.
23. Sivitz W.I., Walsh S., Donohoue P.A., Leibel R.L.: Plasma leptin levels in diabetic and insulin-treated diabetic and normal rats. Metabolism, 47:584-591, 1998.
24. Reutens A.T., Achermann J.C., Ito M., Ito M., Gu W-X., Habiby R.L., Donohoue P.A., Pang S., Hindmarsh P.C., Jameson J.L.: Clinical and functional effects of mutations in the Dax-1 gene in patients with phenotypically disparate presentations of adrenal hypoplasia congenita (AHC). J. Clin. Endocrinol. Metab.84:504-511, 1999.
25. Sivitz W.I., Fink, B.D., Donohoue, P.A.: Fasting and leptin modulate adipose and muscle uncoupling protein: divergent effects between mRNA and protein expression. Endocrinology, 140:1511-1519, 1999.
26. Siddiqi S.U., Donohoue P.A., Van Dyke D., McBrien, D.M.: Premature sexual development in individuals with developmental disabilities. Developmental Medicine and Child Neurology, 41:392-395, 1999.
27. Sivitz W.I., Fink B.D., Morgan D.A., Fox J.M., Donohoue P.A., Haynes W.G.: Sympathetic inhibition, leptin, and uncoupling protein subtype expression in normal fasting rats. Am J. Physiol., 227:E668-E677, 1999.
28. Heo M., Leibel R.L., Boyer B.B., Chung W.K., Koulu M., Karvonen M., Pesonen U., Rissanen A., Laakso M., Uusitupa M., Chagnon Y., Bouchard C., Donohoue P.A., Burns T.L., Shuldiner A.R., Silver K., Andersen R.E., Pederson O., Echwald S., Sorensen T.I.A., Behn P., Permutt M.A., Jacobs K.B., Elston R.C., Hoffman D.J., Allison D.B. : Pooling analysis of genetic data: an example of the association of LEPR polymorphisms with variables related to human adiposity. Genetics 159:1163-1178, 2001.
29. Heo M., Leibel R.L., Fontaine K.R., Boyer B.B., Chung W.K., Koulu M., Karvonen M.K., Pesonen U., Rissanen A., Laakso M., Uusitupa M.I.J, Chagnon Y., Bouchard C., Donohoue P.A., Burns T.L., Shuldiner A.R., Silver K., Andersen R.E., Pederson O., Echwald S., Sorensen T.I.A., Behn P., Permutt M.A., Jacobs K.B., Elston R.C., Hoffman D.J., Gropp E., Allison D.B.: A meta-analytic investigation of linkage and association of common leptin receptor (LEPR) polymorphisms with body mass index and waist circumference. International Journal of Obesity 26:640-646, 2002.
30. Joint LWPES/ESPE CAH Working Group. Consensus statement on 21-hydroxylase deficiency from the Lawson Wilkins Pediatric Endocrine Society and the European Society for Paediatric Endocrinology. J Clin Endocrinol Metab 87:4048-4053, 2002.
31. ESPE/LWPES CAH Working Group: Consensus statement on 21-hydroxylase deficiency from the European Society for Paediatric Endocrinology and the Lawson Wilkins Pediatric Endocrine Society Endocrinology. Hormone Research 58:188-195, 2002.
32. Donohoue P.A., Tao Y.-X., Collins M., Yeo G.S.H., O'Rahilly S., Segaloff D.L.: Deletion of codons 88-92 of the melanocortin-4 receptor gene: a novel deleterious mutation in an obese female. J Clin Endocrinol Metab 88:5841-5845, 2003.
33. Jobe S., Donohoue P.A., Di Paolo G: Deep venous thrombosis and Turner syndrome. Journal of Pediatric Hematology/Oncology 26:272, 2004.
34. Vallette-Kasic S., Pulichino A.M., Gueydan M., Barlier A., David M., Malpuech G., Deal C., Van Vliet G., De Vroede M., Riepe F., Partsch C-J., Sippell W., Berberoglu M., Atasay B., De Zegher F., Kyllo J., Donohoue P., Dechelotte P., Fassnacht M., Noordam K., Dunkel L., Pigeon B., Weill J., Yigit S., Léger J., Brauner R., Leger J., Heinrich J.J., Enjalbert A., Brue T., Drouin J.: A neonatal form of isolated ACTH deficiency frequently associated with Tpit gene mutations. Endocrine Research 30:943-944, 2004.
35. Vallette-Kasic S., Pulichino A.M., Gueydan M., Barlier A., David M., Nicolino M., Malpuech G., Déchelotte P., Deal C., Van Vliet G., De Vroede M., Riepe F.G., Partsch C-J., Sippell W.G., Berberoglu M., Atasay B., De Zegher F., Beckers D., Kyllo J., Donohoue P.A., Fassnacht M., Hahner S., Noordam K., Dunkel L., Hero M., Pigeon B., Weill J., Yigit S., Léger J., Brauner R., Heinrich J.J., Cummings E., Riddell C., Enjalbert A., Brue T., Drouin J.: Congenital isolated ACTH deficiency, an underestimated cause of neonatal death, explained by TPIT mutations. J Clin Endocrinol Metab 90:1323-1331, 2005.
36. Hughes IA, Houk C, Ahmed SF, Lee PA and the LWPES/ESPE Consensus Group: Consensus Statement on Management of Intersex Disorders. 2006: Pediatrics 118:753-757, and e488-500 Archives of Disease in Childhood 91:554-563 Journal of Pediatric Urology (UK) 2: 148-162
37. Donohoue PA, Sivitz WI, Mendoza MCB, Herlein J, Burns TL: Plasma leptin and adiponectin concentrations: Heritability, gender, age, and adiposity effects in families from Muscatine, Iowa, submitted for publication.
 
Books, Chapters, and Reviews
1. a) Donohoue P.A.: Endocrine abnormalities: the thyroid. In: Principles and Practice of Pediatrics, Oski F.A. (ed.), J.B. Lippencott Company, Pub., Philadelphia, 1990, p. 1816. b) Donohoue P.A.: Endocrine abnormalities: the adrenal cortex and the adrenal medulla. Ibid., p. 1824 and p. 1831. c) Donohoue P.A.: Disorders of the newborn: sexual differentiation. Ibid., p. 418.
2. a) Donohoue P.A.: Endocrine abnormalities: the thyroid. In: Principles & Practice of Pediatrics, Second edition, Oski F.A. (ed.), J.B. Lippencott Company Pub., Philadelphia, p. 1992, 1994. b) Donohoue P.A.: Endocrine abnormalities: the adrenal cortex and the adrenal medulla. Ibid, p. 2001 and p. 2008.
3. Migeon C.J., Donohoue P.A.: Adrenal disorders. In: Wilkins' Diagnosis and Treatment of Endocrine Disorders in Childhood and Adolescence, 4th Edition. Kappy M.S., et al (eds)., Charles C. Thomas Pub., Springfield, 1994, p.717 - 856.
4. Donohoue P.A., Parker K.L., Migeon C.J.: Congenital adrenal hyperplasia: In: Schriver C.R., et al (ed.) The Metabolic and Molecular Bases of Inherited Disease, 7th edition, McGraw-Hill Publishing Co., New York, 1995, p. 2929-2963. Update published on CD-ROM, 1997.
5. a) Donohoue P.A.: Endocrine abnormalities: the thyroid. In: Oski's Pediatrics: Principles & Practice, Third edition, DeAngelis C.D., Feigin R.D., McMillan J., Warshaw J.B. (eds.), J.B. Lippincott Company Pub., Philadelphia, 1999, p. 1803-1812. b) Donohoue P.A.: Endocrine abnormalities: the adrenal cortex and the adrenal medulla. Ibid, , p. 1812-1822.
6. Donohoue P.A., Parker K.L., Migeon C.J.: Congenital adrenal hyperplasia. In: Scriver C.R., et al (ed.) The Metabolic and Molecular Bases of Inherited Disease, 8th edition, McGraw-Hill Publishing Co., New York. 2001, p. 4077-4115.
7. Donohoue P.A.: Disorders of the Body Mass. In: Rimoin D.L., Connor J.M.C., Pyeritz R.E., and Korf B.R. (ed) Emery & Rimoin's Principles and Practice of Medical Genetics, 4th edition, Harcourt Health Sciences, Edinburgh. p. 2385-2404, 2001.
8. Donohoue P.A., Saenger, P.H.: Ambiguous Genitalia. In: Finberg L, Kleinman R. (ed) Saunders Manual of Pediatric Practice, 2nd edition, Harcourt Health Sciences Companies, Philadelphia, p.872-875, 2002.
9. Donohoue P.A.: Obesity. In: Behrman R., Kliegman R.M., and Jenson H.B. (ed) Nelson Textbook of Pediatrics, 17th edition, W.B. Saunders Co., Orlando, p. 173-177, 2004.
10. Burns T.L., Peyser P., and Donohoue P.A.: Epidemiology of Childhood Overweight and Obesity. In: Lauer R.M., Burns T.L., and Daniels S. (ed) Prevention of Cardiovascular Disease, Oxford University Press, Oxford, 2005.
11. Donohoue P.A.: Adrenal Disorders. In Kappe M.S., Allen D., Geffner M. (ed) Principles and Practice of Pediatric Endocrinology, Charles C. Thomas, Springfield, p. 357-486, 2005.
12. Donohoue P.A.: Diseases of the Endocrine System: Adrenal cortex and Adrenal Medulla. In: Oski's Pediatrics: Principles & Practice, Fourth edition, McMillan J., Feigin R.D., DeAngelis C.D., Jones, Jr, M.D. (eds.), J.B. Lippincott Company Pub., Philadelphia, p. 2133-2145, 2006.
13. Donohoue P.A.: Disorders of the Body Mass. In: Rimoin D.L., Connor J.M.C., Pyeritz R.E., and Korf B.R. (ed) Emery & Rimoin's Principles and Practice of Medical Genetics, 5th edition, Harcourt Health Sciences, Edinburgh, 2006.
14. Donohoue PA (Editor) Energy Metabolism and Obesity: Research and Clinical Applications. Contemporary Endocrinology Series, (PM Conn, series editor), Humana Press, Tottowa, NJ, 2008.
15. Donohoue PA. Adrenal Disorders. In: Kappy M, Allen D, Geffner M, eds: Pediatric Practice: Endocrinology, McGraw Hill, New York, 2010.
16. Kansra A and Donohoue PA: Hypofunction of the ovaries Hypergonadotropic hypogonadism in females Hypogonadotropic Hypogonadism in females Pseudoprecocity due to lesions of the ovary In: Kliegman RM et al (eds), Nelson's Textbook of Pediatrics 19th edition, Elsevier, Inc., in press
17. Ali O and Donohoue PA: Hypofunction of the testes Hypergonadotropic and hypogonadotropic hypogonadism in males Pseudoprecocity secondary to testicular tumors Gynecomastia, In: Kliegman RM et al (eds), Nelson's Textbook of Pediatrics 19th edition, Elsevier, Inc., In press
18. Donohoue PA: Development and function of the gonads Disorders of Sex Development (DSD) overview 46XX DSD, 46 XY DSD, ovotesticular DSD In: Kliegman RM et al (eds), Nelson's Textbook of Pediatrics 19th edition, Elsevier, Inc. In press
 
Editorials, Letters to Editor, Other
1. Donohoue PA: Disease-oriented testing: a. Congenital adrenal hyperplasia b. Congenital adrenal hyperplasia: 21-hydroxylase deficiency c. Adrenogenital Syndromes In: Critical Inquiry Series (a previously available electronic textbook accessible to paying subscribers), a project of University Pathology Consortium, L.L.C.; Sims K., M.D., CEO; URL: www.criticalinquiry.com., 2001-2004.
2. Donohoue PA: In: UpToDate , Waltham, MA, www.uptodate.com 2011. a. Causes and clinical manifestations of primary adrenal insufficiency in children b. Causes and clinical manifestations of secondary (pituitary) and tertiary (hypothalamic) adrenal insufficiency in children c. Diagnosis of adrenal insufficiency in children d. Treatment of adrenal insufficiency in children
 
Non-Refereed Journal Publications/Original Papers
1. Donohoue P.A., Van Dop C., Jospe N., Migeon C.J.: Congenital adrenal hyperplasia: Molecular mechanisms resulting in 21-hydroxylase deficiency. Acta Endocrinologica Supplementum 279:315-320, 1986.
2. Donohoue P.A., Berkovitz G.: Female pseudohermaphroditism. In: Seminars in Reproductive Endocrinology. Rock J.A. (ed.), Thieme-Stratton Inc., Pub., New York, 5:3, pp. 233-241, August, 1987.
3. Migeon C.J., Donohoue P.A.: Fertility and genitourinary disorders: Fertility in patients with congenital adrenal hyperplasia due to the 21-hydroxylase deficiency. Dialogues in Pediatric Urology 13(7):2-3, 1990.
4. Migeon C.J., Donohoue P.A.: Congenital adrenal hyperplasia due to 21-hydroxylase deficiency: its molecular basis and its remaining therapeutic problems. In: Endocrinology & Metabolism Clinics of North America, Nelson D. (ed.) W.B. Saunders, Philadelphia, 20:277-296, 1991.
5. Donohoue, P.A.: Congenital Adrenal Hyperplasia. International Symposium on A Current Review of Pediatric Endocrinology; course syllabus, Serono Pub., 1999.
6. Donohoue, P.A.: Congenital Adrenal Hyperplasia. International Symposium on A Current Review of Pediatric Endocrinology; course syllabus, Serono Pub., 2003.
 
Abstracts
1. Donohoue P.A., Van Dop C., McLean R.H., White P.C., Migeon C.J.: Congenital adrenal hyperplasia (CAH) resulting from deletion of a 21-hydroxylase gene. The Endocrine Society, June, 1985.
2. McLean R.H., Donohoue P.A., Van Dop C., Carroll M.C., White P.C., Bias W.B., Hochberg M.D., Migeon C.J.: Restriction fragment length polymorphism (RFLP) of the fourth component of complement (C4) in the HLA-A1,B8,DR3,C4AQO,B1,Bfs, haplotype. XI International Complement Workshop, 1985.
3. Jospe N., Donohoue P.A., Van Dop C., McLean R.H., White P.C., Migeon C.J.: Gene deletions of the fourth component of complement C4 and of 21-hydroxylase (21-OH) in salt-losing congenital adrenal hyperplasia. The Endocrine Society, 1986.
4. McLean R.H., Donohoue P.A., Jospe N., Bias W. B., Van Dop C., Migeon C.J.: Restriction fragment analysis of C4A gene duplication. XII International Complement Workshop, 1987.
5. Jospe N., Donohoue P.A., Van Dop C., Migeon C.J.: Crossing-over sites within the 21-hydroxylase (CYP21) genes causing salt-losing congenital adrenal hyperplasia (CAH). Pediatric Research, 23:279A, 1988.
6. Donohoue P.A., Collins M.M., Van Dop C., Migeon, C.J.: Oligonucleotide probes identify single-base transversion in congenital adrenal hyperplasia. The Endocrine Society, 1988.
7. Gearhart J.P., Donohoue P.A., Brown T.R., Migeon C.J., Walsh P.C., Berkovitz G.D.: Long term endocrine follow-up of patients with hypospadias. American Urological Association, Inc., 1989.
8. Van Dop C., Jabs, K.L., Donohoue P.A., Bock G.H., Fivush B.L., Harmon W.E.: Enhanced growth rates during growth hormone therapy in children who grow poorly following renal transplantation. American Society of Nephrology, 1989.
9. Donohoue P.A., Sandrini-Neto R., Collins M.M., Migeon C.J.: Exon 7 NcoI restriction site produced by G->C transversion is a normal polymorphism. The Endocrine Society, 1990.
10. Gelber S.J., Donohoue P.A.: Pituitary gigantism due to growth hormone excess since infancy. The Endocrine Society, 1990.
11. Donohoue P.A., Collins M.M.: Complement C4B-steroid 21-hydroxylase (CYP21) intergenic sequence: comparison with the C4A-CYP21P (pseudogene) intergenic sequence and analysis for regulatory elements. The Endocrine Society, 1992.
12. Kirby-Keyser L., Porter C., Cutshall S., Collins M., Donohoue P.A.,: A CYP21 (steroid 21-hydroxylase) codon change in a patient with congenital adrenal hyperplasia suggests a new mutation mechanism. The Endocrine Society, 1992.
13. Donohoue P.A., Guethlein L., Collins M.M., Van Dop C., Migeon C.J., Bias W.B., Schmeckpeper B.J: The HLA-A3, Cw6,Bw47,DR7 extended haplotypes in salt losing 21-hydroxylase deficiency and in the Old Order Amish: identical MHC class I and II alleles with two crossover sites in the class III region. The Endocrine Society, 1993.
14. Kyllo J.H., Collins M.M., Cuttler L., Rosenfield R.L., Donohoue P.A. Pro-opiomelanocortin gene studies in congenital isolated adrenocorticotrophic hormone deficiency. Clinical Research 41:665A, 1993.
15. Kyllo J.H., Collins M.M., Cuttler L., Rosenfield R.L., Donohoue P.A. Gene studies in congenital isolated adrenocorticotropic hormone deficiency. Pediatric Research, 35:102A, 1994.
16. Kyllo J.H., Collins M.M., Donohoue P.A.: Human steroid 21-hydroxylase promoter activity as assessed with the luciferase gene as a reporter. The Endocrine Society, 1994.
17. Burns T.L., Donohoue P.A., Leibel R.: Identification of obesity genes using sib-pair linkage analysis: The Muscatine Study. American Heart Association. 35th Annual Conference on Cardiovascular Disease Epidemiology and Prevention, Circulation 91:929, 1995.
18. Morgan M.M., Donohoue P.A., Burns T.L., Zirkel T., Becker G.C., Power-Kehoe L., Chung W.K., Chua S.C., Jr., and Leibel R.L.: A polymorphism of D1S85 (VC85) is associated with obesity in the population of Muscatine, Iowa. The Endocrine Society, 1995.
19. Kyllo J.H., Collins M.M., Donohoue P.A.: Human steroid 21-hydroxylase promoter activity is greater than 21-hydroxylase pseudogene promoter activity in steroidogenic cells. The Endocrine Society, 1995.
20. Morgan M.M., Donohoue P.A., Burns T.L., Becker G.C., Binder C.L., Leibel R.L.: A polymorphism of D1S85 (VC85) is associated with obesity in Muscatine, Iowa. Journal of Investigative Medicine 43:462A, 1995.
21. Kyllo J.H., Collins M.M., Donohoue P.A.: Human steroid 21-hydroxylase promoter activity is greater than 21-hydroxylase pseudogene promoter activity in steroidogenic cells. Journal of Investigative Medicine 43:421A, 1995.
22. Sivitz W.I., Bailey H., Donohoue P.A.: Adipose Ob mRNA levels in states of altered circulating glucose and insulin. Diabetes 45(Supplement 2): 249A, 1996.
23. Sivitz, W.I., Donohoue P.A., Leibel R.L.: Plasma leptin levels in diabetic and insulin-treated diabetic rats. Journal of Investigative Medicine 44:370A, 1996.
24. Donohoue P.A., Wedell A.: Normal and CAH mutant 21-hydroxylase promoter activities differ in an in vitro luciferase reporter assay. Joint meeting of the European Society for Paediatric Endocrinology and Lawson Wilkins Pediatric Endocrine Society. Hormone Research 48 (suppl 2):97, 1997.
25. Donohoue P.A., Wedell A., Kyllo J.H., Collins M.M.: Normal and congenital adrenal hyperplasia (CAH) mutant 21-hydroxylase promoter activities differ in reporter assay. The Endocrine Society, 1997.
26. Donohoue P.A., Judisch F.S.: The Kenny Syndrome: Hypoparathyroidism caused by hypomagnesemia, and positive growth response to growth hormone treatment (report of a case). Pediatric Research 43:74A, 1998.
27. Donohoue P.A., Burns T.L., Leibel, R.L. The leptin and leptin receptor loci contribute to variability in body size determinants in a large unselected population from Muscatine, Iowa. The Endocrine Society, 1998.
28. Burns, T.L., Donohoue, P.A., Lauer, R.M., Mendoza, M.C., Nishimura, D.Y., Sheffield, V.C. Loci linked to quantitative body size measures from a genomic scan: The Muscatine Study. Circulation 98:I 374, 1998.
29. Donohoue P.A., Burns T.L., Chung W.K., Leibel R.L.: Polymorphism of exon 12 of the leptin receptor gene (LEPR) and the -3 Adrenergic receptor (B3AR) gene linked to body mass index in humans: The Muscatine Study. Journal of Investigative Medicine, 47:217A, 1999.
30. Heo M, Leibel R.L., Boyer B.B., Chung W.K., Koulu M., Karvonen M., Pesonen U., Rissanen A., Laasko M., Uusitupa M., Chagnon Y., Bouchard C., Donohoue P.A., Burns T.L., Shuldiner A., Silver K., Pederson O., Echwald S., Behn P., Permutt M.A., Allison D.B.: A preliminary meta-analysis of the association of LEPR polymorphisms with anthropometric variables. National Association for the Study of Obesity, 1999.
31. Donohoue P.A., Burns T.L., Mendoza M.C.B., Chung W.K., Leibel R.L.: Lys656Asn variant of the leptin receptor gene (LEPR) and the -3 Adrenergic receptor (B3AR) gene linked to body mass index in humans: The Muscatine Study. Pediatr Res 47:127A, 2000.
32. Donohoue P.A., Collins M.M.: Novel mutation of the human melanocortin-4 receptor (MC4-R) in an obese female. The Endocrine Society, 2000.
33. Tansey M.J., Donohoue P.A.: Multinodular goiter in multiple female family members. The Endocrine Society, 2000.
34. Tansey M.J., Hoffman R.P., Donohoue P.A.: Prevalence and effect of the N363S glucocorticoid receptor polymorphism in body mass index in an obese pediatric population. Journal of Investigative Medicine 48:251A, 2000.
35. Donohoue P.A., Mendoza M.B., Collins, M.M., Hamilton, W.L., Burns, T.L.: The association of genotype, physical activity, and their interaction on age/gender adjusted body mass index (BMI): The Muscatine Study. Pediatric Research 49:127A, 2001.
36. Burns T.L., Donohoue P.A., Chung W.K., Leibel R.L.: Transmission Disequilibrium of genetic loci in Muscatine, Iowa children within the upper decile of BMI. American Heart Association, 2004.
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