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CURRICULUM VITAE

Ulrike P. Kappes MD, PhD
Director, Assistant Professor
Department of Medicine
Division of Administration

OFFICE ADDRESS:
Health Research Center
8701 Watertown Plank Rd
Milwaukee, WI 53226

EDUCATION:
09/1991 - 06/1998 M.D., Julius-Maximilians-University Würzburg, Germany
09/1994 - 02/1999 Ph.D., Julius-Maximilians-University Würzburg, Germany
09/2004 - 06/2005 M.P.H., Concentration: International Health, Harvard T.H. Chan School of Public Health, Boston, MA

POSTGRADUATE TRAINING AND FELLOWSHIP APPOINTMENTS:
01/1999 - 01/2001 Residency, Medizinische Poliklinik, Internal Medicine, Westfalische Wilhelms-University, Munster, Germany
02/2001 - 02/2002 Postdoctoral Fellowship, Dermatology, Friedrich-Schiller-University, Jena, Germany
03/2002 - 08/2004 Postdoctoral Fellowship, Dermatology, Boston University Biomedical Research Laboratories, Boston University, Boston, MA
09/2005 - 12/2005 Residency, Dermatology, Charite, Berlin, Germany
07/2007 - 06/2009 ACMGG-Fellowship in Clinical Molecular Genetics, Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY
10/2019 - 2021 Laboratory Genetics & Genomics Alternative Pathway, Pathology, Wisconsin Diagnostic Laboratories, Medical College of Wisconsin/ Froedtert Hospital, Milwaukee, WI

FACULTY APPOINTMENTS:
07/2015 - Present Assistant Professor of Medicine, Pathology and Pediatrics, Medical College of Wisconsin

ADMINISTRATIVE APPOINTMENTS:
07/2018 - Present GSPMC Liaison with the Global Health Institute, Genomic Sciences and Precision Medicine Center, Medical College of Wisconsin, Milwaukee, WI

EDUCATIONAL ADMINISTRATIVE APPOINTMENTS:
2018 - Present Program Director, International Scholar Program in Clinical Molecular Genetics & Genomics, Genomic Sciences and Precision Medicine Center (GSPMC), Medical College of Wisconsin
07/01/2019 - Present Co-director of Molecular Pathology Rotation for Pathology Residents at MCW, Pathology, Molecular Pathology, Medical College of Wisconsin

HOSPITAL AND CLINICAL ADMINISTRATIVE APPOINTMENTS:
07/2007 - 06/2009 Genetic Specialist, Department of Genetics and Genomic Sciences, Clinical Molecular Genetics Laboratory, Icahn School of Medicine at Mount Sinai, New York, NY
06/2010 - 11/2011 Associate Medical Director, Interleukin Genetics, Inc., Waltham, MA
01/2013 - 06/2015 Assistant Laboratory Director, Research & Development, Myriad Genetics Laboratories, Inc., Salt Lake City, UT
07/2015 - Present Laboratory Director of the Developmental and Neurogenetics Laboratory (clinical whole exome/genome sequencing, SANGER sequencing), Human and Molecular Genetics Center, Developmental and Neurogenetics Laboratory - Sequencing, Medical College of Wisconsin, 8701 Watertown Plank Rd, 8701 Watertown Plank Rd, Milwaukee, WI 53226
07/2015 - Present Laboratory Director of the Advanced Genomics Laboratory (clinical whole genome microarray, whole exome/genome sequencing, SANGER sequencing, qPCR), Division of Pathology and Laboratory Medicine, Advanced Genomics Laboratory, Children’s Hospital of Wisconsin, 8701 Watertown Plank Rd, 8701 Watertown Plank Rd, Milwaukee, WI 53226

HOSPITAL STAFF PRIVILEGES:
01/1999 - 01/2001 Physician, Medizinische Poliklinik, General Medicine and Nephrology, Westfaelische Wilhelms-Universitaet, Munster, Germany, 48149
09/2005 - 12/2005 Physician, Klinik für Dermatologie, Venerologie und Allergologie, General Dermatology, Charite - Universitaetsmedizin Berlin, Berlin, Germany, 10117
2015 - Present Laboratory Director of the Advanced Genomics Laboratory, Pathology & Laboratory Medicine, Pathology & Laboratory Medicine, Children's Hospital of Wisconsin, Milwaukee, WI 53208

SPECIALTY BOARDS AND CERTIFICATION:
Board Certified
Issue DateExpiration
Medical Genetics/Clinical Molecular Genetics
09/01/2011
12/31/2021
 
Certificates
Issued By Issue DateExpiration
Medical License (Germany)
Regierung von Unterfranken, Bavaria, Germany
06/03/1998
None
ECFMG Certificate
Educational Commission for Foreign Medical Graduates (ECFMG).
10/17/2006
None
NCBI Leadership
National Coalition Building Institute (NCBI) International
06/27/2016
None
Laboratory Director Qualification in Clinical Molecular Genetics for the State of New York (Molecular Genetic Testing)
New York State Department of Health
12/07/2018
12/07/2020
 

AWARDS AND HONORS:
1991 - 1998 Scholar of the German Academic Scholarship Foundation, Germany's most reputable scholarship foundation for exceptional students irrespective of their political, ideological or religious convictions
2000 Honorary Scholar, European Society of Internal Medicine (ESIM)

MEMBERSHIPS IN HONORARY AND PROFESSIONAL SOCIETIES:
2008 - Present American Society of Human Genetics (ASHG) (Member)
2013 - Present American College of Medical Genetics and Genomics (ACMGG) (Fellow)
2014 - 2018 American Association for Molecular Pathology (AMP) (Member)
2014 - Present Member of the American Medical Association (AMA) (Member)
2015 - 2017 Human and Molecular Genetics Center (HMGC), Medical College of Wisconsin (Member)
2016 - Present Cardiovascular Genter (CVC), Medical College of Wisconsin (Member)
2017 - Present Genomic Sciences and Precision Medicine Center (GSPMC), Medical College of Wisconsin (Member )
2019 - Present Women in Global Health-Midwest Chapter (Member)

RESEARCH GRANTS/AWARDS/CONTRACTS/PROJECTS:
Active
Non-Peer Review
Title:
In search of causative mutations in neonates with biliary atresia
Source:
Vinmec Research Institute of Stem Cell and Gene Technology, Hanoi, Vietnam
Role:
Collaborator
PI:
Nguyen Thanh Liem, MD
Dates:
07/2019 - Present
 
Prior
Peer Review
Title:
Mutagenesis of Long-Wave Ultraviolet Light (UVA) in Human Skin
Source:
Deutsche Forschungsgemeinschaft (DFG)
Role:
Postdoctoral Fellow
PI:
Thomas Runger, MD
Dates:
03/2002 - 02/2004
Direct Funds:
$135,000 (total for all years)
 
Non-Peer Review
Title:
Skin xeno-transplantation on SCID-mice
Source:
Friedrich Schiller University, Germany
Role:
Principal Investigator
Dates:
09/2001 - 09/2003
Direct Funds:
$50,000 (total for all years)
 

INVITED LECTURES/WORKSHOPS/PRESENTATIONS:
Local
Kappes UP, Molecular genetic testing in prenatal diagnostics, Brigham and Women’s Hospital, Harvard Medical School, Division of Translational Medicine, Professor David Kwiatkowski's Laboratory, Boston, MA, 03/27/2009
Kappes UP, Molecular Genetic Testing for Noonan Syndrome, Twin Zygosity and the Ashkenazi Jewish Diseases, Washington University at St. Louis School of Medicine, Department of Pathology and Immunology, St. Louis, MI, 06/24/2009
Kappes UP, Molecular Genetic Testing for Noonan Syndrome, Twin Zygosity and the Ashkenazi Jewish Diseases, Myriad Genetic Laboratories, Inc., Salt Lake City, UT, 11/12/2012
Kappes UP, Molecular Genetic Testing for Hereditary Cancer Susceptibility, Human and Molecular Genetics Center (HMGC), Medical College of Wisconsin, Milwaukee, WI, 01/16/2015
Kappes UP, Molecular Genetic Sequencing in Hematology and Oncology, Hematology and Oncology Research Retreat; Department of Medicine, Division of Hematology and Oncology, MCW, Milwauukee, WI, 05/25/2016
Kappes UP, Sequencing Services for Children’s Hospital of Wisconsin, Department of Pediatrics Section Chief Meeting Department of Pediatrics, MCW, Milwaukee, WI, 06/03/2016
Kappes UP, Sequencing Capabilities at the Medical College of Wisconsin, Endocrine Research Quarterly Meeting Department of Medicine, Division of Endocrinology, MCW, Milwaukee, WI, 06/20/2016
Kappes UP, Sequencing Capabilities at the Medical College of Wisconsin, Hematology/Oncology Faculty Meeting Department of Medicine, Division of Hematology and Oncology, MCW, Milwaukee, WI, 07/07/2016
Kappes UP, Basel D, The Challenge of Rare Disease Diagnostics and Whole Exome Sequencing, Pediatric Grand Round, Children's Hospital of Wisconsin, 07/29/2016
 
Regional
Kappes UP, Whole Exome and Genome Sequencing in the Genetics Clinic, Course 20240: Translational Genetics; HMGC Translational Science Seminar Series, Medical College of Wisconsin, 11/2016
Kappes UP, Translational Genetics in Precision Medicine, Course 20240: Translational Genetics; GSPMC Translational Science Seminar Series, Medical College of Wisconsin, 11/2017
 
International
Kappes UP, Molecular mechanisms of UVA-induced mutagenesis, Molecular Biology Meeting at the Environmental Health Research Institute, Heinrich-Heine-Universität Düsseldorf, Düsseldorf, Germany, 05/26/2004
Kappes, UP, Molecular Genetic Testing for Hereditary Cancer and Rare Diseases, Consultative Workshops and Orientation to Vinmec Healthcare System - Clinical Care, Medical Education, Research Initiatives, and Cancer Symposium, Hanoi, Vietnam, 02/22/2017 - 02/24/2017
 

PEER REVIEWED WORKSHOPS/PRESENTATIONS:
Local
peer reviewed before asked to present):
 
National
Kappes UP, Runger TM., No major role of 8-oxoguanine in UVA-mutagenesis., The 65th Meeting of the Society of Investigative Dermatology (SID) 2004, Providence, RI, 2004
Bowles KR, Singh N, Kappes UP, Mundt E, Warf B, Morris B, Pruss D. Roa BB, Wenstrup R, Determining the clinical significance of BRCA1 and BRCA2 intronic and exonic splicing variants., Meeting of the National Society of Genetic Counselors (NSGC) 2014, New Orleans, LA, 2014
Helbling D, McCarrier J, Basel D, Kappes U, Dimmock D, Expanding the phenotype-genotype correlation in a patient with PIGN associated neurodevelopmental anomalies., Meeting of the American College of Medical Genetics (ACMG) 2016, Tampa, FL, 2016
Kappes UP, Scharer G, Virlee E, Zemlicka N, Aggarwal P, Lorier R, Broeckel U, Verification of very small copy number variants (micro CNVs) detected on whole genome CMA analysis and implications for clinical reporting, Association of Molecular Pathology, Annual Meeting Nov 1-3, 2018, San Antonio, TX, 2018
 
International
Kappes UP, Luo D, Runger TM, Contribution of pyrimidine dimers to UVA-mutagenesis., The Fourth Joint Meeting of the European Society for Dermatological Research (ESDR), Japanese Society for Investigative Dermatology (JSID) and Society for Investigative Dermatology (SID), Miami, FL, 2003
Kappes UP, Luo D, Runger TM. Hinweise auf einen Beitrag von Pyrimidin-Dimeren zur UVA-Mutagenese. XXX. Annual Meeting of the 'Arbeitsgemeinschaft Dermatologische Forschung' (ADF), Frankfurt/M, Germany, 2003
 

COMMITTEE SERVICE:
Medical College
2015 - 2016 Committee member to guide the future direction and structure of the Clinical Diagnostics Laboratory, HMGC Genetic Sequencing Steering Committee, Human and Molecular Genetics Center, Department of Medicine, Medical College of Wisconsin
2016 Committee member, MCW Search Committee to fill the chair position in the Department of Pediatrics, Division of Genetics, Medical Genetics, Department of Pediatrics, Medical College of Wisconsin
2018 - Present Committee member, MCW Search Committee to fill the positions of the senior and a junior laboratory director in the Wisconsin Diagnostic Laboratories, Division of Cytogenetics, Cytogenetics, Department of Pathology, Medical College of Wisconsin
2018 Subcommittee member, Assessment of Molecular Genetics Technologies on Campus, Cytogenetics, Department of Pathology, Medical College of Wisconsin
 

MEDICAL COLLEGE TEACHING ACTIVITIES:
Medical Student Education
07/2019 - Present Lectures in the 'Molecules to Cells' course. Students will learn about integrated concepts of biochemistry, medical genetics, human development and cell and tissue biology. The goal of the curriculum is for students to become aware of the contributions these disciplines bring to future developments in clinical diagnosis and treatment.
 

EXTRAMURAL TEACHING:
Resident and Fellow Education
05/06/2008 Icahn School of Medicine at Mount Sinai, New York, Department of Genetics and Genomic Sciences, Clinical case conference; Molecular genetic testing for familial hyperinsulinism.
06/26/2008 Icahn School of Medicine at Mount Sinai, New York, Department of Genetics and Genomic Sciences, Department of Genetics and Genomic Sciences Journal Club; Molecular genetics of nicotine dependence and abstinence: Whole genome association using 520,000 SNPs.
11/20/2008 Icahn School of Medicine at Mount Sinai, New York, Department of Genetics and Genomic Sciences, Department of Genetics and Genomic Sciences Journal Club; DNA methylation markers and early recurrence in stage 1 lung cancer.
03/11/2009 Icahn School of Medicine at Mount Sinai, New York, Department of Genetics and Genomic Sciences, ACMG-Fellowship Program; Seminar: Short tandem repeat genotyping in determining twin zygosity.
02/08/2017 Medical College of Wisconsin/Froedtert Hospital, Department of Medicine, PGY2_Academic Half Day, Lecture: Genetics in Primary Care Medicine Part I
02/15/2017 Medical College of Wisconsin/Froedtert Hospital, Department of Medicine, PGY2_Academic Half Day, Lecture: Genetics in Primary Care Medicine-Part II
02/15/2017 Medical College of Wisconsin/Froedtert Hospital, Department of Medicine, PGY1_Academic Half Day, Lecture: Genetics in Primary Care Medicine Part I
03/29/2017 Medical College of Wisconsin/Froedtert Hospital, Department of Medicine, PGY1_Academic Half Day, Lecture: Genetics in Primary Care Medicine Part II
04/2019 - Present Medical College of Wisconsin, Department of Pathology, Training pathology residents & fellows in clinical molecular genetics for their rotation in Molecular Pathology
 

PROGRAMMATIC DEVELOPMENTS:
Educational Programs
Faculty
2018 - Present International Scholar Program in Clinical Molecular Genetics & Genomics: Academic Outreach Project to foster the Development of Molecular Genetic Testing in Low- and Middle Income Countries
 
 
 
 

COMMUNITY SERVICE ACTIVITIES:
2010 - 2011 Associate Medical Director at Interleukin Genetics, Inc. • Disease spectrum: obesity, periodontal disease, cardiac disease, osteoporosis, vitamin B12-deficiency • Methods used: DNA extraction from buccal swabs, PCR, Single Base Extension (SBE) Analysis • Customization of diet and nutrition for weight management in relations to genetic profiles • Laboratory supervision • Data analysis and report review • Assay development for commercial and research panels • Review and improvement of SOPs
2013 - 2015 Assistant Laboratory Director at Myriad Genetic Laboratories, Inc. • Disease spectrum: hereditary cancer syndromes • Methods used: DNA extraction from blood samples/ buccal swabs/fibroblasts, PCR, qPCR, Next-Generation Sequencing, targeted Sanger Sequencing, microarray, MLPA, biomarker analysis • Classification and interpretation of sequencing variants and large rearrangements • Review of scientific literature • Application of risk and splice prediction models • Report generation and sign-out of molecular genetic test • Communication of test results to health care providers • Active involvement in quality assurance program • Development of a procedure for complex director report review • Development of a training program for new laboratory directors • Review and improvement of standard operating procedures (SOPs)
 

GLOBAL HEALTH ACTIVITIES:
02/20/2017 - 02/25/2017 Hanoi, Vietnam. Visiting professor and invited speaker at the 'Consultative Workshops and Orientation to Vinmec Healthcare System'. Discussions between visiting doctors and scientists from the United States and Vietnam on improving medical education, healthcare, research, and health care policies in Vietnam. Cross-country visits of Vinmec hospitals (Vietnam’s primary private healthcare system) to assess quality standards.
2018 - Present Launch of an International Scholar Program in Clinical Molecular Genetics & Genomics at the Medical College of Wisconsin: Academic Outreach Project to foster the Development of Molecular Genetic Testing in Low- and Middle Income Countries
2019 - Present Hosting International Scholar in Clinical Molecular Genetics & Genomics: Kien Trung Tran, PhD; Genomic Scientist Vinmec Research Institute of Stem Cell and Gene Technology 458 Minh Khai, Hai Ba Trung, Hanoi, Vietnam
 


BIBLIOGRAPHY
Refereed Journal Publications/Original Papers
1. Kappes U, Schanz G, Gerhardt U, Matzkies F, Suvelack B, Hohage H. Influence of age on the prognosis of renal transplant recipients. Am J Nephrol 2001; 21(4):259-63.
2. Kappes UP, Goritz N, Wigger-Alberti W, Heinemann C, Elsner P. Tandem application of sodium lauryl sulfate and n-propanol does not lead to enhancement of cumulative skin irritation. Acta Derm Venereol 2001;81(6):403-5.
3. Westermann GW, Buerger H, Kappes U, Matzkies F, Kisters K. Dermatofibrosarcoma protuberans with lung metastasis in a patient with progressive systemic sclerosis. South Med J 2002;95(3):363-5.
4. Kappes UP, Barta U, Merkel U, Balogh A, Elsner P. High plasma levels of 8-methoxypsoralen following bath water delivery in dermatological patients. Skin Pharmacol Appl Skin Physiol 2003;16(5):305-12.
5. Kappes U, , Schliemann-Willers S, Bankova L, Heinemann C, Fluhr JW, Fischer TW, Ziemer M, Schubert H, Elsner P. The quality of human skin xenografts on SCID mice: A noninvasive bioengineering approach. Br J Dermatol. 2004 Nov;151(5):971-6.
6. Kappes UP, Runger TM. No major role for 7,8-dihydro-8-oxoguanine in ultraviolet light-induced mutagenesis. Radiat Res. 2005 Oct;164(4):440-5.
7. Kappes UP, Luo, D, Potter M, Runger TM. Short- and long-wave ultraviolet light (UVA and UVB) induce similar mutations in human skin cells. J Invest Dermatol 2006; 126(3):667-75.
8. Peterson JF, Basel GD, Bick DP, Chirempes B, Grignon JW, Weik L, Kappes UP. A Rare Combination of Functional Disomy Xp, Deletion Xq13.2-q28 Spanning the XIST Gene, and Duplication 3q25.33-q29 in a Female with der(X)t(X;3)(q13.2;q25.33). J Pediatr Genet. 2018 Mar;7(1):23-28.
9. Peterson JF, Geddes GC, Basel DG, Schippman D, Grignon JW Jr., vanTuinen P, Kappes UP. Inheritance of a Balanced t(12;20)(q24.33;p12.2) and Unbalanced der(13)t(7;13)(p21.3;q33.2) from a Maternally Derived Double Balanced Translocation Carrier. J Pediatr Genet. 2018 Mar;7(1):35-39.
 
Books, Chapters, and Reviews
1. Runger TM, Kappes UP. Mechanisms of mutation formation with long-wave ultraviolet light (UVA). Photodermatol Photoimmunol Photomed 2008; 24(1):2-10.
2. Kappes UP. Skin ageing and wrinkles: clinical and photographic scoring. J Cosmet Dermat 2004;3(1):23-25.
3. Kappes UP, Elsner P. Clinical and photographic scoring of skin aging. Skin Pharmacol Appl Skin Physiol 2003;16(2):100-7.
4. Kappes UP, Elsner P. The SCID-hu mouse model as a tool in dermatopharmacology research: new options and a review of the literature. Exog Dermatol 2002;1:176-179.
5. Kappes U. Hip joint revisions using a diaphysial anchoring system (Wagner revision prostheses), Julius-Maximilians-University Wϋrzburg, Germany. Reihe Humanmedizin Bd. 233, Marburg: Tectum Verlag 1999.
 
Abstracts
1. Bowles KR, Singh N, Kappes UP, Mundt E, Warf B, Morris B, Pruss D, Roa BB, Wenstrup R. Determining the clinical significance of BRCA1 and BRCA2 intronic and exonic splicing variants. Meeting of the National Society of Genetic Counselors (NSGC) 2014, New Orleans, LA
2. Helbling D, McCarrier J, Basel D, Kappes U, Dimmock D. expanding the phenotype-genotype correlation in a patient with PIGN associated neurodevelopmental anomalies. Meeting of the American College of Medical Genetics (ACMG) 2016, Tampa, FL
3. Kappes U at al. Severe Intellectual Disability in a Patient with Turner Syndrome Features. (Molecular and Cytogenetic Diagnostics #873F). Presented at the 66th Annual Meeting of The American Society of Human Genetics, October 21, 2016, Vancouver, Canada.
4. Kappes UP, Scharer G, Virlee E, Zemlicka N, Aggarwal P, Lorier R, Broeckel U. Verification of very small copy number variants (micro CNVs) detected on whole genome CMA analysis and implications for clinical reporting. Meeting of the Association for Molecular Pathology, Nov. 1-3, 2018, San Antonio, TX; J Mol Diagn. Nov 2018;20(6); G025
 

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