CURRICULUM VITAE
Yuri M. Sheinin MD, PhD
Yuri M. Sheinin MD, PhD
Associate Professor
Department of Pathology
Division of Administration
Department of Pathology
Division of Administration
OFFICE ADDRESS: |
Froedtert/MCW Laboratory Building |
9200 W Wisconsin Ave |
Milwaukee, WI 53226 |
Fax: (414) 805-8444 |
HOSPITAL STAFF PRIVILEGES: |
08/2018 - Present Pathologist, Pathology, Administration, Froedtert Memorial Lutheran Hospital, Milwaukee, WI |
08/2018 - Present Pathologist, Laboratory, Pathology, Froedtert Menomonee Falls Hospital, Menominee Falls, WI |
08/2018 - Present Pathologist, Laboratory, Pathology, Froedtert West Bend Hospital, West Bend, WI |
06/2020 - Present Pathologist, Laboratory, Pathology, Froedtert South, Kenosha, WI |
SPECIALTY BOARDS AND CERTIFICATION: |
Licensure | Number | Issue Date | Expiration |
Illinois Medical License | 036132927 | 05/13/2013 | 09/30/2020 |
Nebraska Medical License | 28192 | 10/02/2014 | 10/01/2018 |
Wisconsin Medical License | 69697 | 07/11/2018 | 10/31/2023 |
PEER REVIEWED WORKSHOPS/PRESENTATIONS: |
Regional |
Jain P, Linsky P, Sheinin Y, A rare case of resected cytokeratin-negative small cell lung carcinoma, 13th Annual Midwestern Conference: Update Course in Diagnostic, Milwaukee, WI, 09/23/2022 - 09/25/2022 |
National |
Sheinin Y, Muraviev G, Histological variant and volume of nephroblastoma (Rus), 1st Byelorussian Meeting of Pathologists and Forensic Physicians, Vitebsk, Belarus, 10/01/1990 - 10/02/1990 |
Gruber R, Redlich K, Schiller C, Ho GM, Sheinin Y, Peterlik M, Interaction of 1,25(OH)2D3 with thyroid hormones – In vitro model for Osteoclastogenesis in murine bone marrow (Ger), 12th Spring Meeting of Austrian Society for Pathology, Vienna, Austria, 03/14/1993 - 03/15/1993 |
Hareuvini M, Sheinin Y, Merimsky O, Keydar I, Chaitchick S, Immunodiagnostic follow-up of breast cancer patients, The Annual Meeting of Cancer Biology Research Center of Tel Aviv University, Eilat, Israel, 05/06/1993 - 05/08/1993 |
Sheinin Y, Determination of karyometric parameters in breast cancer (Rus), Conference on Computer Hardware and Software in Medicine, Dnepropetrovsk, Ukraine, 09/22/1993 - 09/25/1993 |
Tong WM, Bises G, Sheinin Y, Peterlik M, Cross HS, Expression of the Vitamin D receptor and antimitotic effect of Vitamin D in normal and neoplastic colon epithelium on different stages of tomorigenesis (Ger), Austrian Society for Endocrinology and Metabolism, 2nd Annual Meeting, Seefeld/Tirol, Austria, 03/13/1997 - 03/14/1997 |
Sheinin Y, Manhardt T, Peterlik M, Cross HS, mRNA and protein expression of the vitamin D receptor and epidermal growth factor receptor as well as p53 in human colon carcinoma (Ger), 12th Spring Meeting of Austrian Society for Pathology, Vienna, Austria, 03/14/1997 - 03/15/1997 |
Kallay E, Sheinin Y, Peterlik M, Cross HS, Hormonal regulation of the expression of "Ca2+ -Sensing"receptor in human colon cancer cells (Ger), Austrian Society for Endocrinology and Metabolism, 3rd Annual Meeting, Seefeld/Tirol, Austria, 03/19/1998 - 03/21/1998 |
Cross HS, Sheinin Y, Hofer H, Tong WM, Peterlik M, Expression of the vitamin D/vitamin D receptor system in human colorectal tumor cells: implication for adjuvant vitamin D therapy (Ger), Austrian Society for Endocrinology and Metabolism, 3rd Annual Meeting, Seefeld/Tirol, Austria, 03/19/1998 - 03/21/1998 |
Cross HS, Sheinin Y, Hofer H, Tong WM, Peterlik M, Differential expression of the vitamin D/vitamin D receptor system in human colorectal tumor cells: feasibility of adjuvant vitamin D therapy, AACR Annual Meeting, New Orleans, LA, 03/28/1998 - 04/01/1998 |
Cross HS, Bareis P, Sheinin Y, Kallay E, Hofer H, Bises G, Manhardt T, Wenzl E, Wrba F, Kriwanek S, Peterlik M, Vitamin D/vitamin D receptor system in adjuvant therapy for colon carcinoma (Ger), 29th Annual Meeting of Austrian Society for Internal Medicine, Salzburg, Austria, 09/24/1998 - 09/26/1998 |
Varssano D, Sheinin Y, Schreiber L, Russ V, Hazarbassanov R, Light and electron microscopic study: alcohol and hypertonic saline on the corneal epithelium, Israel Society for Vision and Eye Research, 25th Annual Meeting, Neve Ilan, Israel, 03/17/2005 - 03/18/2005 |
Tollefson MK, Sheinin Y, Cheville JC, Leibovich BC, Blute ML, Lohse CM, Kwon ED, High tumor expression of Ki-67 is an independent predictor of poor outcome
Among patients treated surgically for clear cell renal cell carcinoma, 7th Annual SUO Meeting to Discuss Current Topics and Strategies Co-Sponsored by: Society of Urologic Oncology/National Cancer Institute Conference Center National Institutes of Health, Bethesda, Maryland, 11/30/2006 - 12/02/2006 |
Roth TJ, Lohse CM, Kuntz SM, Leibovich BC, Blute ML, Cheville JC, Sheinin Y, Kwon ED, Tumor vasculature expression of B7-H3 in renal cell carcinoma, AUA 2007 Annual Meeting, Anaheim, CA, 05/19/2007 - 05/24/2007 |
Roth TJ, Hoffmann NE, Thompson RH, Lohse CM, Kuntz SM, Leibovich BC, Blute ML, Sheinin Y, Kwon ED, Coinhibitory molecule expression and lymphocytic infiltration in non-clear cell renal cell carcinoma, AUA 2008 Annual Meeting, Orlando, FL, 05/17/2008 - 05/22/2008 |
Boorjian SA, Frank I, Lohse CM, Crispen PL, Leibovich BC, Sheinin Y, Kwon ED, T cell coregulatory molecule expression in urothelial cell carcinoma: a potential target for therapy, AUA 2008 Annual Meeting, Orlando, FL, 05/17/2008 - 05/22/2008 |
Hoffmann NE, Sheinin Y, Lohse CM, Parker AS, Leibovich BC, Jiang Z, Kwon ED, External validation of IMP3 expression as an independent prognostic marker for metastatic progression and death for patients with clear cell renal cell carcinoma, AUA 2008 Annual Meeting, Orlando, FL, 05/17/2008 - 05/22/2008 |
Hangu Y, Sheinin V, Sheinin Y, An automated image segmentation and classification algorithm for immunohistochemically stained tumor cell nuclei., Medical Imaging 2009: Image Processing, Lake Buena Vista, FL, 02/2009 |
Sheinin Y, Wells L, Fu K, Synchronous T-Cell Gamma/Delta Hepatosplenic Lymphoma and Lymphoplasmacytic Lymphoma in Spleen: A Case Report, CAP Annual Meeting 2012, San Diego, CA, 09/09/2012 - 09/12/2012 |
Kravtsov A, Sheinin Y, Hunt B, Hartley C, Giorgadze T., Efficiency of PD-L1 Testing on Non-Small Cell Lung Cancer Cytology Specimens: An Institutional Experience., 107th USCAP Annual Meeting, March 2019, National Harbor, MD., 03/2019 |
Ronen N, Sheinin Y., Rare surgical lung biopsy findings of metastatic pulmonary calcification associated with chronic renal failure., ASCP 2020 Meeting, Virtual, 09/09/2020 - 09/12/2020 |
Onyenekwu C, Sheinin Y, Exogenous Lipoid Pneumonia Presenting as an Enlarging Lung Nodule in a Patient with a Long-standing Usage of Petroleum Jelly., ASCP 2020 Meeting, Virtual, 09/09/2020 - 09/12/2020 |
Onyenekwu C, Iczkowski K, Sheinin Y, Paraganglioma of the Urinary Bladder Metastatic to the Lung in a Patient with SDHB Gene Mutation: A Case Report., ASCP 2020 Meeting, Virtual, 09/09/2020 - 09/12/2020 |
Onyenekwu C, Hopp A, Sheinin Y, Giorgadze T, Recurrent Respiratory Papillomatosis with Pulmonary Involvement and Malignant Transformation: Cytologic-Histologic Correlation of Disease Progression, CAP20 Meeting, Virtual, 10/2020 |
Onyenekwu C, Sheinin Y, Histopathologic and Molecular Findings from Cryobiopsy Transbronchial Tissues for Interstitial Lung Disease., USCAP21, Las Angeles, CA, 03/19/2021 - 03/24/2021 |
Puzyrenko A, Kravtsov A, Sheinin Y, PD-L3 and PD-L1 expression in metaplastic breast carcinoma., CAP21 Meeting, Virtual, 09/25/2021 - 09/28/2021 |
Ratiani M, Farooq A, Jorns J, Sheinin Y, Cytokeratin 7 and HER2 negative Mammary Paget Disease without an underlying in situ and invasive carcinoma: Report of a Rare Case., CAP21 Meeting, Virtual, 09/25/2021 - 09/28/2021 |
Onyenekwu C, Sheinin Y, Epstein-Barr Virus-Associated Smooth Muscle Tumors of the Lung and Adrenal: Incidental Findings in a Kidney Transplant Patient., CAP21 Meeting, Virtual, 09/25/2021 - 09/28/2021 |
Puzyrenko A, Sheinin Y, Granulomatous-lymphocytic interstitial lung disease as the first manifestation of an underlying immune deficiency and its possible relationship with malignancies., CAP21 Meeting, Virtual, 09/25/2021 - 09/28/2021 |
Onyenekwu C, Iczkowski K, Sheinin Y, B3 Thymoma with Clear Cell Features Masquerading as Metastatic Clear Cell Carcinoma of the Kidney., CAP21 Meeting, Virtual, 09/25/2021 - 09/28/2021 |
Puzyrenko A, Taylor C, Sheinin Y, PD-L1 expression in non-small cell lung cancer in adenocarcinomas with lepidic growth pattern, CAP22 Meeting, New Orleans, LA, 10/08/2022 - 10/11/2022 |
International |
Hareuvini M, Sheinin Y, Keydar I, Chaitchick S, Assessment of prognostic factors in Stage I breast cancer - a retrospective study, Hellenic Society for Breast Cancer Research. 1st International Congress, Corfu, Greece, 09/01/1993 - 09/03/1993 |
Hareuveni M, Sheinin Y, Merimsky O, Kovner F, Dotan D, Horev J, Keyda I, Chaitchik S, Immunodiagnostic follow-up of breast cancer patients., Breast Cancer Symposium, San Antonio, TX, 12/1993 |
Cross HS, Bischof M, Tong WM, Hofer H, Ho GM, Bises G, Kallay E, Sheinin Y, Bajna E, Manhardt T, Peterlik M, Vitamin D analogs: effect on growth and differentiation, International Workshop on the vitamin D-Cascade, Vienna, Austria, 05/22/1997 - 05/23/1997 |
Sheinin Y, Manhardt T, Peterlik M, Cross HS, Tissue distribution of mRNA and protein of vitamin D receptor and epidermal growth factor receptor in human colon cancer, 10th Workshop on Vitamin D, Strasbourg, France, 05/24/1997 - 05/29/1997 |
Cross HS, Tong WM, Hofer H, Sheinin Y, Peterlik M, The intrinsic 1,25(OH)2D3/VDR system of human colonic epithelial cells: upregulation during tumor progression, 10th Workshop on Vitamin D, Strasbourg, France, 05/24/1997 - 05/29/1997 |
Cross HS, Sheinin Y, Hofer H, Tong WM, Kallay E, The vitamin D/vitamin D receptor system during human colorectal tumor progression: application for adjuvant therapy, International Institute of Anticancer Research. Abstracts of the International Conference on new Anticancer Agents, Athens, Greece, 10/12/1997 - 10/15/1997 |
Cross HS, Bischof M, Bareis P, Kallay E, Sheinin Y, Hofer H, Kriwanek S, Peterlik M, Expression of the vitamin D/vitamin D receptor system during human colorectal tumor progression, International conference on progress in bone and mineral research 1998 and 6th Austrian Meeting on Osteoporosis, Vienna, Austria, 04/23/1998 - 04/25/1998 |
Kallay E, Sheinin Y, Peterlik M, Cross HS, Hormonal regulation of the expression of an extracellular calcium-sensing receptor in human colon cancer cells, International conference on progress in bone and mineral research 1998 and 6th Austrian Meeting on Osteoporosis, Vienna, Austria, 04/23/1998 - 04/25/1998 |
Cross HS, Tong WM, Sheinin Y, Hofer H, Peterlik M, The Vitamin D/VDR system has a protective function against human colorectal tumor progression, 4th International symposium on predictive oncology and therapy, Nice, France, 10/24/1998 - 10/27/1998 |
Kallay E, Sheinin Y, Peterlik M, Cross HS, Is nutritional calcium responsible for growth modulation of human colon cancer cells?, 4th International symposium on predictive oncology and therapy, Nice, France, 10/24/1998 - 10/27/1998 |
Segev O, Chumakov O, Nevo Z, Sheinin Y, Madan-Shapiro L, Yayon A, Transgenic mice model for human achondroplasia, 11th International Workshop on Calcified Tissues, Eilat, Israel, 02/07/1999 - 02/11/1999 |
Segev O, Chumakov O, Nevo Z, Sheinin Y, Madan-Shapiro L, Yayon A, Transgenic mice model for human achondroplasia, 26th European Symposium on Calcified Tissues, Maastricht, The Netherlands, 05/07/1999 - 05/11/1999 |
Sheinin Y, Lifschitz-Mercer B, Lavi S, Protein phosphatase 2Calpha expression in normal human tissues: immunohistochemical study, 23th International Congress of the International Academy of Pathology and the 14th World Congress of Academic and Environmental Pathology, Nagoya, Japan, 10/15/2000 - 10/20/2000 |
Tollefson MK, Sheinin Y, Cheville JC, Leibovich BC, Blute ML, Lohse CM, Kwon ED, High tumor expression of KI-67 is an independent predictor of poor outcome among patients treated surgically for clear cell renal cell carcinoma, 29th Congress of the Internationale da Urologie, Paris, France, 09/02/2007 - 09/06/2007 |
Olsen KD, Kwon ED, Sheinin Y, Lohse CM, Kasperbauer JL, Moore EJ, B7-H1, B7-H3, and CA1X Expression in Squamous Cell Carcinoma of Head and Neck Tumors, 7th International Conference on Head and Neck Cancer, San Francisco, CA, 07/19/2008 - 07/23/2008 |
Sheinin Y, Kwon ED, B7-H1 and B7-H3 expression in granulomatous inflammation, 2011 ASCP Annual Meeting/WASPaLM XXVI World Congress, Las Vegas, NV, 10/19/2011 - 10/22/2011 |
Sheinin Y, Radio SJ, Dimaio DJ, Early atherosclerosis and thrombophilia in a patient with methylenetetrahydrofolate reductase A1298C and autosomal-dominant polycystic kidney disease, 2011 ASCP Annual Meeting/WASPaLM XXVI World Congress, Las Vegas, NV, 10/19/2011 - 10/22/2011 |
Sheinin Y, Johansson SL, Primary Neuroendocrine Carcinoma of the Trachea: A Rare Malignancy, 8th International Conference on Head and Neck Cancer, Toronto, Ontario, Canada, 07/21/2012 - 07/25/2012 |
Sheinin Y, Sullivan ME, Thurow TF, Mahajan A, Patel AS, Helenowski IB, Khan SA, A Detailed Histologic Analysis of Prior Benign Biopsies in Women with Breast Cancer by Hormone Receptor Status, USCAP 103rd Annual Meeting, San Diego, CA, 03/01/2014 - 03/07/2014 |
COMMITTEE SERVICE: |
Medical College of Wisconsin |
08/2021 - Present Member, Faculty Council, Medical College of Wisconsin |
Hospital |
09/2014 - 06/2017 Member, Scientific Review Committee, University of Nebraska Medical Center |
07/01/2018 - Present Member, Multidisciplinary Breast Tumor Board, Froedtert Memorial Lutheran Hospital |
07/01/2018 - Present Member, Multidisciplinary Thoracic Tumor Conference, Froedtert Memorial Lutheran Hospital |
BIBLIOGRAPHY |
Refereed Journal Publications/Original Papers |
1. Sheinin Y, Muraviev G.
Morphometrical parameters of epithelial cell nuclei in benign prostatic hyperplasia (Rus)
Topical Problems of Oncology and Medical Radiology, Minsk, 1990 (pp.64-68).
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2. Sheinin Y, Muraviev G.
Lymphoid infiltration of stroma in benign prostatic hyperplasia and adenocarcinoma of the prostate (Rus)
Care of Public Health in Byelorussia, 1992, Feb. (pp. 39-41). |
3. Sheinin Y.
Determination of nucleolar organizer regions in benign prostatic hyperplasia and adenocarcinoma of the prostate (Rus)
Clinical Oncology, Kiev. 1992, Nov. (pp.44-47). |
4. Sheinin Y, Mavrichev A.
Adenocarcinoma and benign hyperplasia of the prostate (Rus)
Topical Problems of Oncology and Medical Radiology, Minsk, 1992 (pp.63-65).
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5. Sheinin Y, Muraviev G.
The degree of anaplasia and the tumor volume in transitional cell carcinoma of the bladder (Rus)
Topical Problems of Oncology and Medical Radiology, Minsk, 1992. (pp. 61-63).
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6. Sheinin Y.
Immunohistochemical detection of tumor markers in breast cancer (Rus)
Topical Problems of Oncology and Medical Radiology. Minsk, 1994. (pp. 43-46).
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7. Mavrichev A, Sheinin Y, Sukonko O, Krasny S.
Prognostic significance of morphological factors in renal cell carcinoma (Rus)
Care of Public Health in Byelorussia,1994, Dec. (pp. 11-14).
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8. Tong WM, Bises G, Sheinin Y, Ellinger A, Genser D, Pötzi R, Wrba F, Wenzl E, Roka R, Neuhold N, Peterlik M, Cross HS. Establishment of primary cultures from human colonic tissue during tumor progression: vitamin-D responses and vitamin-D-receptor expression. Int J Cancer. 1998 Jan 30; 75(3):467-72. |
9. Tong WM, Ellinger A, Sheinin Y, Cross HS. Epidermal growth factor receptor expression in primary cultured human colorectal carcinoma cells. Br J Cancer. 1998 Jun; 77(11):1792-8. |
10. Segev O, Chumakov I, Nevo Z, Givol D, Madar-Shapiro L, Sheinin Y, Weinreb M, Yayon A. Restrained chondrocyte proliferation and maturation with abnormal growth plate vascularization and ossification in human FGFR-3(G380R) transgenic mice. Hum Mol Genet. 2000 Jan 22; 9(2):249-58. |
11. Sheinin Y, Kallay E, Wrba F, Kriwanek S, Peterlik M, Cross HS. Immunocytochemical localization of the extracellular calcium-sensing receptor in normal and malignant human large intestinal mucosa. J Histochem Cytochem. 2000 May; 48(5):595-602. |
12. Sheinin Y, Kaserer K, Wrba F, Wenzl E, Kriwanek S, Peterlik M, Cross HS. In situ mRNA hybridization analysis and immunolocalization of the vitamin D receptor in normal and carcinomatous human colonic mucosa: relation to epidermal growth factor receptor expression. Virchows Arch. 2000 Nov; 437(5):501-7. |
13. Lifschitz-Mercer B, Sheinin Y, Ben-Meir D, Bramante-Schreiber L, Leider-Trejo L, Karby S, Smorodinsky NI, Lavi S. Protein phosphatase 2Calpha expression in normal human tissue: an immunohistochemical study. Histochem Cell Biol. 2001 Jul; 116(1):31-9. |
14. Rozenblatt-Rosen O, Mosonego-Ornan E, Sadot E, Madar-Shapiro L, Sheinin Y, Ginsberg D, Yayon A. Induction of chondrocyte growth arrest by FGF: transcriptional and cytoskeletal alterations. J Cell Sci. 2002 Feb 1; 115(Pt 3):553-62. |
15. Tollefson MK, Thompson RH, Sheinin Y, Lohse CM, Cheville JC, Leibovich BC, Kwon ED. Ki-67 and coagulative tumor necrosis are independent predictors of poor outcome for patients with clear cell renal cell carcinoma and not surrogates for each other. Cancer. 2007 June 26; 110(4):783-90. |
16. Roth TJ, Sheinin Y, Lohse CM, Kuntz SM, Frigola X, Inman BA, Krambeck AE, McKenney ME, Karnes RJ, Blute ML, Cheville JC, Sebo TJ, Kwon ED. B7-H3 ligand expression by prostate cancer: a novel marker of prognosis and potential target for therapy. Cancer Res. 2007 Aug 15;67(16):7893-900. |
17. Leibovich BC, Sheinin Y, Lohse CM, Thompson RH, Cheville JC, Zavada J, Kwon ED. Carbonic anhydrase IX is not an independent predictor of outcomes for patients with clear cell renal cell carcinoma. J Clin Oncol. 2007 Oct 20; 25(30):4757-64. |
18. Hoffmann NE, Sheinin Y, Lohse CM, Parker AS, Leibovich BC, Jiang Z, Kwon ED. External validation of IMP3 expression as an independent prognostic marker for metastatic progression and death for patients with clear cell renal cell carcinoma. Cancer. 2008 Apr 1; 112(7):1471-9. |
19. Boorjian SA, Sheinin Y, Crispen PL, Farmer SA, Lohse CM, Kuntz SM, Leibovich BC, Kwon ED, Frank I. T-cell coregulatory molecule expression in urothelial cell carcinoma: clinicopathologic correlations and association with survival. Clin Cancer Res. 2008 Aug 1; 14(15):4800-8. |
20. Crispen PL, Sheinin Y, Roth TJ, Lohse CM, Kuntz SM, Frigola X, Thompson RH, Boorjian SA, Dong H, Leibovich BC, Blute ML, Kwon ED. Tumor cell and tumor vasculature express of B7-H3 predict survival in clear cell renal cell carcinoma. Clin Cancer Res. 2008 Aug 15; 14(16):5150-7. |
21. Parker AS, Lohse CM, Leibovich BC, Cheville JC, Sheinin YM, Kwon ED. Comparison of digital image analysis versus visual assessment to assess surviving expression as an independent predictor of survival for patients with clear cell renal cell carcinoma. Human Pathology. 2008 Aug; 39(8):1176-84. |
22. Boorjian SA, Sheinin Y, Crispen PL, Lohse CM, Kwon ED, Leibovich BC. Hormone receptor expression in renal angiomyolipoma: clinicopathologic correlation. Urology. 2008 Oct; 72(4):927-32. |
23. Kushwaha SS, Raichlin E, Sheinin Y, Kremers WK, Chandrasekaran K, Brunn GJ, Platt JL. Sirolimus affects cardiomyocytes to reduce left ventricular mass in heart transplant recipients. Eur Heart J. 2008 Nov; 29(22):2742-50. |
24. Chavin G, Sheinin Y, Crispen PL, Boorjian SA, Roth TJ, Rangel L, Blute ML, Sebo TJ, Tindall DJ, Kwon ED, Karnes RJ. Expression of immunosuppressive B7-H3 ligand by hormone-treated prostate cancer tumors and metastases. Clin Cancer Res. 2009 Mar 15; 15(6):2174-80. |
25. Parker AS, Leibovich BC, Lohse CM, Sheinin Y, Kuntz SM, Eckel-Passow JE, Blute ML, Kwon ED. Development and evaluation of BioScore: a biomarker panel to enhance prognostic algorithms for clear cell renal cell carcinoma. Cancer. 2009 May 15; 115(10):2092-103. |
26. Boorjian SA, Sheinin Y, Crispen PL, Lohse CM, Leibovich BC, Kwon ED. T-cell co-regulatory molecule expression in renal angiomyolipoma and pulmonary lymphangioleimyomatosis. Urology. 2009 Dec; 74(6):1359-64. |
27. Eckel-Passow JE, Lohse CM, Sheinin Y, Crispen PL, Krco CJ, Kwon ED. Tissue microarrays: one size does not fit all. Diagn Pathol. 2010 Jul 7; 5:48. |
28. Parker AS, Heckman MG, Sheinin Y, Wu KJ, Hilton TW, Diehl NN, Pisansky TM, Schild SE, Kwon ED, Buskirk SJ. Evaluation of B7-H3 expression as a biomarker of biochemical recurrence after salvage radiation therapy for recurrent prostate cancer. Int J Radiat Oncol Biol Phys. 2011 Apr 1; 79(5):1343-9. |
29. Mansfield AS, Roden AC, Peikert T, Sheinin Y, Harrington SM, Krco CJ, Dong H, Kwon ED. B7-H1 expression in malignant pleural mesothelioma is associated with sarcomatoid histology and poor prognosis. J Thoracic Oncology 2014 Jul; 9(7):1036-40. |
30. Pandey P, Rachagani S, Das S, Seshacharyulu P, Naslavsky N, Pan Z, Sheinin Y, Smith BL, Peters HL, Radhakrishnan P, McKenna NR,Panapakkam Giridharan SS, Haridas D, Kaur S, Hollingsworth MA, MacDonald RG, Meza JL, Caplan S, Batra SK, Solheim JC. Amyloid Precursor-Like Protein 2 (APLP2) Affects the Actin Cytoskeleton and Increases Pancreatic Cancer Growth and Metastasis. Oncotarget 2015 Feb 10;6(4):2064-75. |
31. Pai P, Rachagani S, Lakshmanan I, Macha MA, Sheinin Y, Smith LM, Ponnusamy MP, Batra SK. The canonical Wnt pathway regulates the metastasis-promoting mucin MUC4 in pancreatic ductal adenocarcinoma. Mol Oncol. 2016 Feb;10(2):224-39. |
32. Hein AL, Seshacharyulu P, Rachagani S, Sheinin YM, Ouellette MM, Ponnusamy MP, Mumby MC, Batra SK, Yan Y. PR55α subunit of protein phosphatase 2A supports the tumorigenic and metastatic potential of pancreatic cancer cells by sustaining hyperactive oncogenic signaling. Cancer Res. 2016 Apr 15;76(8):2243-53. |
33. Hein AL, Post CM, Sheinin YM, Lakshmanan I, Natarajan A, Enke CA, Batra SK, Ouellette MM, Yan Y. RAC1 GTPase promotes the survival of breast cancer cells in response to hyper-fractionated radiation treatment. Oncogene. 2016 Dec 8;35(49):6319-6329. |
34. Das S, Rachagani S, Sheinin Y, Smith LM, Gurumurthy CB, Roy HK and Batra SK. Mice deficient in Muc4 are resistant to experimental colitis and
colitis-associated colorectal cancer. Oncogene 2016 May 19;35(20):2645-54.
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35. Pai P, Rachagani S, Dhawan P, Sheinin YM, Macha MA, Qazi AK, Chugh S, Ponnusamy MP, Mallya K, Pothuraju R, Batra SK. MUC4 is negatively regulated through the Wnt/β-catenin pathway via the Notch effector Hath1 in colorectal cancer. Genes Cancer. 2016 May 7(5-6):154-68. |
36. Goetz B, An W, Mohapatra B, Zutshi N, Iseka F, Storck MD, Meza J, Sheinin Y, Band V, Band H. A novel CBL-Bflox/flox mouse model allows tissue-selective fully conditional CBL/CBL-B double-knockout: CD4-Cre mediated CBL/CBL-B deletion occurs in both T-cells and hematopoietic stem cells. Oncotarget. 2016 Aug 9;7(32):51107-51123. |
37. Chugh S, Meza J, Sheinin YM, Ponnusamy MP, Batra SK. Loss of N-acetylgalactosaminyltransferase 3 in poorly differentiated pancreatic cancer: augmented aggressiveness and aberrant ErbB family glycosylation. Br J Cancer. 2016 Jun 14;114(12):1376-86. |
38. Krishn SR, Kaur S, Sheinin YM, Smith LM, Gautam SK, Patel A, Jain M, Juvvigunta V, Pai P, Lazenby AJ, Roy HK, Batra SK. Mucins and associated O-glycans based immunoprofile for stratification of colorectal polyps: clinical implication for improved colon surveillance. Oncotarget. 2017 Jan 24;8(4):7025-7038. |
39. Karmakar S, Seshacharyulu P, Lakshmanan I, Vaz AP, Chugh S, Sheinin YM, Mahapatra S, Batra SK, Ponnusamy MP. hPaf1/PD2 interacts with OCT3/4 to promote self-renewal of ovarian cancer stem cells. Oncotarget. 2017 Feb 28;8(9):14806-14820. |
40. Wang Y, Xie Y, Li J, Peng ZH, Sheinin Y, Zhou J, Oupický D. Tumor-Penetrating Nanoparticles for Enhanced Anticancer Activity of Combined Photodynamic and Hypoxia-Activated Therapy. ACS Nano. 2017 Feb 28;11(2):2227-2238. |
41. Luan H, Mohapatra B, Bielecki TA, Mushtaq I, Mirza S, Jennings TA, Clubb RJ, An W, Ahmed D, El Ansari R, Storck MD, Mishra NK, Guda C, Sheinin YM, Meza JL, Raja S, Rakha EA, Band V, Band H. Loss of the nuclear pool of ubiquitin ligase CHIP/STUB1 in breast cancer unleashes the MZF1-cathepsin pro-oncogenic program. Cancer Res. 2018 Mar 6. |
42. Aithal A, Junker WM, Kshirsagar P, Das S, Kaur S, Orzechowski C, Gautam SK, Jahan R, Sheinin YM, Lakshmanan I, Ponnusamy MP, Batra SK, Jain M. Development and characterization of carboxy-terminus specific monoclonal antibodies for understanding MUC16 cleavage in human ovarian cancer. PLoS One. 2018 Apr 30;13(4). |
43. Hsu AH, Lum MA, Shim KS, Frederick PJ, Morrison CD, Chen B, Lele SM, Sheinin YM, Daikoku T, Dey SK, Leone G, Black AR, Black JD. Crosstalk between PKCα and PI3K/AKT Signaling Is Tumor Suppressive in the Endometrium. Cell Rep. 2018 Jul 17;24(3):655-669. |
44. Kanvinde S, Chhonker YS, Ahmad R, Yu F, Sleightholm R, Tang W, Jaramillo L, Chen Y, Sheinin Y, Li J, Murry DJ, Singh AB, Oupick D. Pharmacokinetics and efficacy of orally administered polymeric chloroquine as macromolecular drug in the treatment of inflammatory bowel disease. Acta Biomater. 2018 Dec;82:158-170.
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45. Seshacharyulu P, Rachagani S, Muniyan S, Siddiqui JA, Cruz E, Sharma S, Krishnan R, Killips BJ, Sheinin Y, Lele SM, Smith LM, Talmon GA, Ponnusamy MP, Datta K, Batra SK. FDPS cooperates with PTEN loss to promote prostate cancer progression through modulation of small GTPases/AKT axis. Oncogene. 2019 Jun;38(26):5265-5280. |
46. Jahan R, Ganguly K, Smith LM, Atri P, Carmicheal J, Sheinin Y, Rachagani S, Natarajan G, Brand RE, Macha MA, Grandgenett PM, Kaur S, Batra SK. Trefoil factor(s) and CA19.9: A promising panel for early detection of pancreatic cancer. EBioMedicine. 2019 Apr;42:375-385. |
47. Wang Y, Xie Y, Li J, Peng ZH, Sheinin Y, Zhou J, Oupický D. Correction to Tumor-Penetrating Nanoparticles for Enhanced Anticancer Activity of Combined Photodynamic and Hypoxia-Activated Therapy. ACS Nano. 2019 Apr 23;13(4):4855. |
48. Wright KD, Miller BS, El-Meanawy S, Tsaih SW, Banerjee A, Geurts AM, Sheinin Y, Sun Y, Kalyanaraman B, Rui H, Flister MJ, Sorokin A. The p52 isoform of SHC1 is a key driver of breast cancer initiation. Breast Cancer Res. 2019 Jun 15;21(1):74. PMCID: PMC6570928 |
49. Wang F, Qi XM, Wertz R, Mortensen M, Hagen C, Evans J, Sheinin Y, James M, Liu P, Tsai S, Thomas J, Mackinnon A, Dwinell M, Myers CR, Bartrons Bach R, Fu L, Chen G. p38γ MAPK Is Essential for Aerobic Glycolysis and Pancreatic Tumorigenesis. Cancer Res. 2020 Aug 15;80(16):3251-3264. PMCID: PMC9358694 |
50. Kravtsov O, Hartley CP, Sheinin Y, Hunt BC, Felix JC, Giorgadze T. Utility of PD-L1 testing on non-small cell lung cancer cytology specimens: An institutional experience with interobserver variability analysis. Ann Diagn Pathol. 2020 Oct;48:151602. |
51. Puzyrenko A, Shponka V, Sheinin Y, Giorgadze T, Nomani L. Primary pulmonary mucoepidermoid carcinoma: Cyto-histologic correlation and review of the literature. Ann Diagn Pathol. 2021 Apr;51:151698. |
52. Puzyrenko A, Felix JC, Sun Y, Rui H, Sheinin Y. Acute SARS-CoV-2 pneumonitis with cytotoxic CD8 positive T-lymphocytes: Case report and review of the literature. Pathol Res Pract. 2021 Apr;220:153380. PMCID: PMC7883708 |
53. Poelaert BJ, Knoche SM, Larson AC, Pandey P, Seshacharyulu P, Khan N, Maurer HC, Olive KP, Sheinin Y, Ahmad R, Singh AB, Batra SK, Rachagani S, Solheim JC. Amyloid Precursor-like Protein 2 Expression Increases during Pancreatic Cancer Development and Shortens the Survival of a Spontaneous Mouse Model of Pancreatic Cancer. Cancers (Basel). 2021 Mar 26;13(7). PMCID: PMC8036577 |
54. Felix JC, Sheinin YM, Suster D, Ronen N, Ratiani M, Vanden Heuvel T, Winge E, Patton MD, Rau MJ, Ge L, Sun Y, Udhane SS, Langenheim JF, Rui H. Diffuse interstitial pneumonia-like/macrophage activation syndrome-like changes in patients with COVID-19 correlate with length of illness. Ann Diagn Pathol. 2021 Aug;53:151744. PMCID: PMC8053602 |
55. Puzyrenko A, Jacobs ER, Sun Y, Felix JC, Sheinin Y, Ge L, Lai S, Dai Q, Gantner BN, Nanchal R, North PE, Simpson PM, Rui H, Benjamin IJ. Pneumocytes are distinguished by highly elevated expression of the ER stress biomarker GRP78, a co-receptor for SARS-CoV-2, in COVID-19 autopsies. Cell Stress Chaperones. 2021 Sep;26(5):859-868. PMCID: PMC8357488 |
56. Fish BL, MacVittie TJ, Gao F, Narayanan J, Gasperetti T, Scholler D, Sheinin Y, Himburg HA, Hart B, Medhora M. Rat Models of Partial-body Irradiation with Bone Marrow-sparing (Leg-out PBI) Designed for FDA Approval of Countermeasures for Mitigation of Acute and Delayed Injuries by Radiation. Health Phys. 2021 Oct 01;121(4):419-433. PMCID: PMC8577554 |
57. Puzyrenko A, Felix JC, Ledeboer NA, Sun Y, Rui H, Sheinin Y. Cytotoxic CD8-positive T-lymphocyte infiltration in the lungs as a histological pattern of SARS-CoV-2 pneumonitis. Pathology. 2022 Jun;54(4):404-408. PMCID: PMC8572726 |
58. Jain PV, Squires C, Gasparri M, Sheinin Y. Nivolumab induced pulmonary sarcoid-like granulomas with a concurrent pleural schwannoma: A pathologic-radiologic correlation of a rare condition mimicking metastatic melanoma. Ann Diagn Pathol. 2022 Apr;57:151880. |
59. Ratiani M, Farooq A, Jorns J, Sheinin Y. Keratin 7 and ERBB2 Negative Mammary Paget Disease Without an Underlying in Situ and Invasive Carcinoma. Int J Surg Pathol. 2022 Aug;30(5):590-592. |
60. SenthilKumar G, Rokkas CK, Sheinin YM, Linsky PL. Rare and complicated functional posterior mediastinal paraganglioma. BMJ Case Rep. 2022 Jun 07;15(6). PMCID: PMC9174829 |
61. Gundacker ND, Gonzalez JA, Sheinin YM, Hirschtritt T. Hot Tub Lung: Case Report and Review of the Literature. WMJ. 2022 Jul;121(2):E31-E33. |
62. Yeo H, Sheinin V, Sheinin Y. An automated image segmentation and classification algorithm for immunohistochemically stained tumor cell nuclei Progress in Biomedical Optics and Imaging - Proceedings of SPIE. 2009;7259. |
63. Peng ZH, Jogdeo CM, Li J, Xie Y, Wang Y, Sheinin YM, Kopeček J, Oupický D. Tumor Microenvironment-Responsive Polymeric iRGD and Doxorubicin Conjugates Reduce Spontaneous Lung Metastasis in an Orthotopic Breast Cancer Model. Pharmaceutics. 2022 Aug 18;14(8). PMCID: PMC9416753 |
64. Jain PV, Thompson J, Sheinin Y. Resected cytokeratin-negative small cell lung carcinoma. BMJ Case Rep. 2023 Apr 03;16(4). PMCID: PMC10083812 |
Editorials, Letters to Editor, Other |
1. Leibovich BC, Sheinin Y, Lohse CM, Thompson RH, Cheville JC, Zavada J, Kwon ED. In reply Journal of Clinical Oncology. 2008;26(22):3811-3812. |
2. Leibovich BC, Sheinin Y, Lohse CM, Thompson RH, Cheville JC, Zavada J, Kwon ED. In reply Journal of Clinical Oncology. 2008;26(18):3107-3109. |
Abstracts |
1. Nedzved M, Sheinin Y.
The features of brain vascular channel in the presence of diseases of prosencefalic group (Rus)
Perinatal Pathology and Teratology, Saratov.1980 (pp.49-50).
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2. Sheinin Y, Muraviev G.
Histological variant and volume of nephroblastoma (Rus)
Theses of the 1st Byelorussian Meeting of Pathologists and Forensic Physicians, Vitebsk, October 1-2, 1990. Minsk (pp.186-187).
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3. Sheinin Y, Muraviev G, Feshchenko S.
Localization of heparan sulfate in normal, hyperplastic, and malignant tissues of the prostate (Rus)
Proceedings of the 3rd Annual Meeting of Byelorussian Oncologists, December 11-12, 1991. Minsk(pp.122-124).
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4. Sheinin Y.
Determination of silver-binding nucleolar organizer regions (AgNORs) in prostate and bladder tumors (Rus)
Proceedings of the 3rd Annual Meeting of Byelorussian Oncologists. December 11-12, 1991. Minsk (pp.125-126).
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5. Sheinin Y.
Breast cancer: advanced techniques for diagnosis and prognosis
Publication of the UICC fellowship programme. Association of UICC Fellows. Membership Directory. 1994, Geneva, Switzerland (pp. 201-202).
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6. Sheinin Y, Manhardt T, Peterlik M, Cross HS.
Tissue distribution of mRNA and protein of vitamin D receptor and epidermal growth factor receptor in human colon cancer
Proceedings of the 10th Workshop on Vitamin D. May 24-29, 1997. Strasbourg, France (p. 240).
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7. Cross HS, Tong WM, Hofer H, Sheinin Y, Peterlik M.
The intrinsic 1,25(OH)2D3/VDR system of human colonic epithelial cells: upregulation during tumor progression
Vitamin D: chemistry, biology and clinical applications of the steroid hormone. Proceedings of the 10th Workshop on Vitamin D. May 24-29, 1997. Strasbourg, France (pp. 495-496).
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8. Cross HS, Sheinin Y, Hofer H, Tong WM, Peterlik M.
Expression of the vitamin D/vitamin D receptor system in human colorectal tumor cells: implication for adjuvant vitamin D therapy (Ger)
Wiener Klinische Wochenschrift (The Middle European Journal of medicine), Heft 6, 1998, March 27, 1998. S3.
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9. Kallay E, Sheinin Y, Peterlik M, Cross HS.
Hormonal regulation of the expression of "Ca2+ -Sensing"receptor in human colon cancer cells (Ger)
Wiener Klinische Wochenschrift (The Middle European Journal of medicine), Heft 6, 1998, March 27, 1998. S7.
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10. Cross HS, Sheinin Y, Hofer H, Tong WM, Kallay E.
The vitamin D/vitamin D receptor system during human colorectal tumor progression: application for adjuvant therapy
International Institute of Anticancer Research. Abstracts of the International Conference on new Anticancer Agents. October 12-15, 1997. Athens, Greece. Anticancer Research, Vol. 17, 1997 (pp. 4072-4073).
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11. Cross HS, Sheinin Y, Hofer H, Tong WM, Peterlik M.
Differential expression of the vitamin D/vitamin D receptor system in human colorectal tumor cells: feasibility of adjuvant vitamin D therapy
AACR Annual Meeting, March 28-April 1, 1998. New Orleans, LA.
Proc. Amer. Assoc. Cancer Res, Vol. 39, 1998, Abs. N1326.
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12. Kallay E, Sheinin Y, Peterlik M, Cross HS.
Is nutritional calcium responsible for growth modulation of human colon cancer cells?
4th International symposium on predictive oncology and therapy. October 24-27, 1998. Nice, France. Cancer detection and prevention, Vol 22, Suppl. 1, 1998 abs. 262.
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13. Cross HS, Tong WM, Sheinin Y, Hofer H, Peterlik M.
The Vitamin D/VDR system has a protective function against human colorectal tumor progression
4th International symposium on predictive oncology and therapy. October 24-27, 1998. Nice, France. Cancer detection and prevention, Vol. 22, Suppl. 1,1998 abs. 264.
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14. Segev O, Chumakov O, Nevo Z, Sheinin Y, Madan-Shapiro L, Yayon A.
Transgenic mice model for human achondroplasia
26th European Symposium on Calcified Tissues. May 7-11, 1999. Maastricht, The Netherlands. Calcified Tissues International. 1999;64, Suppl. 1, (p.199).
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15. Sheinin Y, Lifschitz-Mercer B, Lavi S.
Protein phosphatase 2Calpha expression in normal human tissues: immunohistochemical study
23th International Congress of the International Academy of Pathology and the 14th World Congress of Academic and Environmental Pathology. October 15-20, 2000. Nagoya, Japan. Pathology International, Vol. 50, Suppl. 2000, Abs. 8-18-127.
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16. Roth TJ, Lohse CM, Kuntz SM, Leibovich BC, Blute ML, Cheville JC, Sheinin Y, Kwon ED.
Tumor vasculature expression of B7-H3 in renal cell carcinoma.
AUA 2007 Annual Meeting. May 19-24, 2007. Anaheim, CA. Abs. 448.
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17. Parker AS, Lohse CM, Sheinin Y, Kwon ED, Cheville JC.
Comparison of survivin expression by digital imaging analysis and visual assessment among a cohort of patients with clear cell renal cell carcinoma
AUA 2007 Annual Meeting. May 19-24, 2007. Anaheim, CA. Abs. 1295.
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18. Tollefson MK, Sheinin Y, Cheville JC, Leibovich BC, Blute ML, Lohse CM, Kwon ED.
High tumor expression of KI-67 is an independent predictor of poor outcome among patients treated surgicaly for clear cell renal cell carcinoma
29th Congress of the Société Internationale d’Urologie. September 02-06, 2007. Paris, France.
Urology, Volume 70, Issue 3, Supplement 1, September 2007, Pages 10-11.
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19. Olsen KD, Kwon ED, Sheinin Y, Lohse CM, Kasperbauer JL, Moore EJ.
B7-H1, B7-H3, and CA1X Expression in Squamous Cell Carcinoma of Head and Neck Tumors
7th International Conference on Head and Neck Cancer. July 19-23, 2008. San Francisco, CA.
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20. Sheinin Y, Kwon ED.
B7-H1 and B7-H3 expression in granulomatous inflammation
Am J Clin Pathol 2011;136:A23.
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21. Sheinin Y, Radio SJ, Dimaio DJ.
Early atherosclerosis and thrombophilia in a patient with methylenetetrahydrofolate reductase A1298C and autosomal-dominant polycystic kidney disease
Am J Clin Pathol 2011;136:A35.
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22. Sheinin Y, Johansson SL.
Primary Neuroendocrine Carcinoma of the Trachea: A Rare Malignancy
JAMA Otolaryngology - Head & Neck Surgery 8th International Conference on Head and Neck Cancer, July 21-25, 2012. Toronto, ON, Canada. P083.
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23. Sheinin YM, Sullivan ME, Thurow Ta, Mahajan A, Patel A, Helenowski IB, Khan SA. A Detailed Histologic Analysis of Prior Benign Biopsies in Women with Breast Cancer by Hormone Receptor Status. USCAP 103rd Annual Meeting Abstracts Mod Pathol 27, 34–90 (2014) |
24. Thurow T, Martinez de Ubago J, Sheinin Y, Mahajan A, Rohan S, Siziopikou K. Androgen Receptor and Bcl-2 Expression in Ductal Carcinoma In Situ of the Breast. USCAP 2014, March 4, 2014. |
25. Kravtsov A, Sheinin Y, Hunt B, Hartley C, Giorgadze T. Efficiency of PD-L1 Testing on Non-Small Cell Lung Cancer Cytology Specimens: An Institutional Experience. Abstracts from USCAP 2019: Quality Assurance (1897-1977). Mod Pathol 32, 1–69 (2019) |
26. Mohammed A, Mazher S, Yelisetty A, Sheinin Y, Franco RA, Ramalingam VS. A Serious Complication of Common Variable Immunodeficiency.American Journal of Respiratory and Critical Care Medicine 2020;201:A1368 |
27. Mohammed A, Mazher S, Siddiqui N, Sheinin Y, and Santo Tomas LH.
Constrictive Bronchiolitis with Mixed Spirometry Pattern. American Journal of Respiratory and Critical Care Medicine 2020;201:A3314 |
28. Onyenekwu C, Sheinin Y. Exogenous Lipoid Pneumonia Presenting as an Enlarging Lung Nodule in a Patient with a Long-standing Usage of Petroleum Jelly. American Journal of Clinical Pathology, Volume 154, Issue Supplement_1, October 2020, Page S39 |
29. Onyenekwu C, Iczkowski K, Sheinin Y. Paraganglioma of the Urinary Bladder Metastatic to the Lung in a Patient with SDHB Gene Mutation: A Case Report.
American Journal of Clinical Pathology, Volume 154, Issue Supplement_1, October 2020, Page S32
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30. Ronen N, Sheinin Y. Rare surgical lung biopsy findings of metastatic pulmonary calcification associated with chronic renal failure. American Journal of Clinical Pathology, Volume 154, Issue Supplement_1, October 2020, Pages S37–S38
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31. Onyenekwu C, Sheinin Y. Epstein-Barr Virus-Associated Smooth Muscle Tumors of the Lung and Adrenal: Incidental Findings in a Kidney Transplant Patient.
CAP21 Meeting, Virtual Abstract Program, September 25-28, 2021.
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32. Onyenekwu C, Iczkowski K, Sheinin Y. B3 Thymoma with Clear Cell Features Masquerading as Metastatic Clear Cell Carcinoma of the Kidney. CAP21 Meeting, Virtual Abstract Program, September 25-28, 2021. |
33. Ratiani M, Farooq A, Jorns J, Sheinin, Y. Cytokeratin 7 and HER2 negative Mammary Paget Disease without an underlying in situ and invasive carcinoma: Report of a Rare Case. CAP21 Meeting, Virtual Abstract Program, September 25-28, 2021. |
34. Puzyrenko A, Sheinin Y.Granulomatous-lymphocytic interstitial lung disease as the first manifestation of an underlying immune deficiency and its possible relationship with malignancies. CAP21 Meeting, Virtual Abstract Program, September 25-28, 2021. |
35. Puzyrenko A, Kravtsov A, Sheinin Y. PD-L3 and PD-L1 expression in metaplastic breast carcinoma. CAP21 Meeting, Virtual Abstract Program, September 25-28, 2021. |
36. Onyenekwu C, Sheinin Y. Histopathologic and Molecular Findings from Cryobiopsy Transbronchial Tissues for Interstitial Lung Disease. USCAP 2022, March 19-24, 2021. |
Peer Reviewed Educational Products |
1. Sheinin Y.
Ph.D. thesis: "Morphogenesis of the prostatic adenocarcinoma " Minsk, Belarus, 1992
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Patents |
1. Kwon ED, Lohse CM, Sheinin Y, Kuntz SM, Roth TR.
B7-H3 in cancer. WO/2008/100934
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