Medical College of Wisconsin
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Adriano Marchese PhD

Adriano Marchese PhD


Institution: Medical College of Wisconsin
Department: Biochemistry

Member of the Cancer Center


  • Mitochondria-targeted drugs stimulate mitophagy and abrogate colon cancer cell proliferation. (Boyle KA, Van Wickle J, Hill RB, Marchese A, Kalyanaraman B, Dwinell MB) J Biol Chem 2018 Sep 21;293(38):14891-14904 PMID: 30087121 PMCID: PMC6153299 08/09/2018    
  • Endocytosis is required for CC chemokine receptor type 4 (CXCR4)-mediated Akt activation and antiapoptotic signaling. (English EJ, Mahn SA, Marchese A) J Biol Chem 2018 07 20;293(29):11470-11480 PMID: 29899118 PMCID: PMC6065176 06/15/2018    
  • Detecting Cell Surface Expression of the G Protein-Coupled Receptor CXCR4. (Nevins AM, Marchese A) Methods Mol Biol 2018;1722:151-164 PMID: 29264804 12/22/2017       1 Citations
  • β-Arrestin1 and Signal-transducing Adaptor Molecule 1 (STAM1) Cooperate to Promote Focal Adhesion Kinase Autophosphorylation and Chemotaxis via the Chemokine Receptor CXCR4. (Alekhina O, Marchese A) J Biol Chem 2016 Dec 09;291(50):26083-26097 PMID: 27789711 PMCID: PMC5207078 10/30/2016       3 Citations
  • Monitoring Chemokine Receptor Trafficking by Confocal Immunofluorescence Microscopy. (Marchese A) Methods Enzymol 2016;570:281-92 PMID: 26921951 PMCID: PMC5201001 02/29/2016       2 Citations
  • Regulation of GPCR Trafficking by Ubiquitin. (Kennedy JE, Marchese A) Prog Mol Biol Transl Sci 2015;132:15-38 PMID: 26055053 PMCID: PMC4699176 06/10/2015       21 Citations
  • The endosomal sorting complex required for transport pathway mediates chemokine receptor CXCR4-promoted lysosomal degradation of the mammalian target of rapamycin antagonist DEPTOR. (Verma R, Marchese A) J Biol Chem 2015 Mar 13;290(11):6810-24 PMID: 25605718 PMCID: PMC4358107 01/22/2015       10 Citations
  • The ubiquitin ligase deltex-3l regulates endosomal sorting of the G protein-coupled receptor CXCR4. (Holleman J, Marchese A) Mol Biol Cell 2014 Jun 15;25(12):1892-904 PMID: 24790097 PMCID: PMC4055268 05/03/2014       25 Citations
  • Endocytic trafficking of chemokine receptors. (Marchese A) Curr Opin Cell Biol 2014 Apr;27:72-7 PMID: 24680433 PMCID: PMC4268779 04/01/2014       46 Citations
  • Modulation of the CXC chemokine receptor 4 agonist activity of ubiquitin through C-terminal protein modification. (Tripathi A, Saini V, Marchese A, Volkman BF, Tang WJ, Majetschak M) Biochemistry 2013 Jun 18;52(24):4184-92 PMID: 23697661 PMCID: PMC4113718 05/24/2013       13 Citations
  • Ubiquitin-dependent regulation of G protein-coupled receptor trafficking and signaling. (Marchese A, Trejo J) Cell Signal 2013 Mar;25(3):707-16 PMID: 23201781 PMCID: PMC3593103 12/04/2012       62 Citations
  • AP-3 regulates PAR1 ubiquitin-independent MVB/lysosomal sorting via an ALIX-mediated pathway. (Dores MR, Paing MM, Lin H, Montagne WA, Marchese A, Trejo J) Mol Biol Cell 2012 Sep;23(18):3612-23 PMID: 22833563 PMCID: PMC3442409 07/27/2012       27 Citations
  • Novel roles for the E3 ubiquitin ligase atrophin-interacting protein 4 and signal transduction adaptor molecule 1 in G protein-coupled receptor signaling. (Malik R, Soh UJ, Trejo J, Marchese A) J Biol Chem 2012 Mar 16;287(12):9013-27 PMID: 22275353 PMCID: PMC3308791 01/26/2012       25 Citations
  • Structural determinants of ubiquitin-CXC chemokine receptor 4 interaction. (Saini V, Marchese A, Tang WJ, Majetschak M) J Biol Chem 2011 Dec 23;286(51):44145-52 PMID: 22039044 PMCID: PMC3243501 11/01/2011       23 Citations
  • The CXC chemokine receptor 4 ligands ubiquitin and stromal cell-derived factor-1α function through distinct receptor interactions. (Saini V, Staren DM, Ziarek JJ, Nashaat ZN, Campbell EM, Volkman BF, Marchese A, Majetschak M) J Biol Chem 2011 Sep 23;286(38):33466-77 PMID: 21757744 PMCID: PMC3190899 07/16/2011       55 Citations
  • Ubiquitination of GPCRs. (Caballero A, Marchese A) Methods Mol Biol 2011;746:251-9 PMID: 21607861 PMCID: PMC4699430 05/25/2011       3 Citations
  • Ubiquitin receptor binding and signaling in primary human leukocytes. (Saini V, Romero J, Marchese A, Majetschak M) Commun Integr Biol 2010 Nov;3(6):608-10 PMID: 21331255 PMCID: PMC3038079 02/19/2011    
  • Small ubiquitin-like modifier modification of arrestin-3 regulates receptor trafficking. (Wyatt D, Malik R, Vesecky AC, Marchese A) J Biol Chem 2011 Feb 04;286(5):3884-93 PMID: 21118812 PMCID: PMC3030389 12/02/2010       25 Citations
  • Arrestin-2 interacts with the endosomal sorting complex required for transport machinery to modulate endosomal sorting of CXCR4. (Malik R, Marchese A) Mol Biol Cell 2010 Jul 15;21(14):2529-41 PMID: 20505072 PMCID: PMC2903679 05/28/2010       63 Citations
  • CXC chemokine receptor 4 is a cell surface receptor for extracellular ubiquitin. (Saini V, Marchese A, Majetschak M) J Biol Chem 2010 May 14;285(20):15566-76 PMID: 20228059 PMCID: PMC2865327 03/17/2010       85 Citations
  • Ubiquitination of chemokine receptors. (Marchese A) Methods Enzymol 2009;460:413-22 PMID: 19446738 PMCID: PMC4445356 05/19/2009       11 Citations
  • Ubiquitination regulates proteolytic processing of G protein-coupled receptors after their sorting to lysosomes. (Hislop JN, Henry AG, Marchese A, von Zastrow M) J Biol Chem 2009 Jul 17;284(29):19361-70 PMID: 19433584 PMCID: PMC2740561 05/13/2009       59 Citations
  • The E3 ubiquitin ligase atrophin interacting protein 4 binds directly to the chemokine receptor CXCR4 via a novel WW domain-mediated interaction. (Bhandari D, Robia SL, Marchese A) Mol Biol Cell 2009 Mar;20(5):1324-39 PMID: 19116316 PMCID: PMC2649280 01/01/2009       49 Citations
  • Cross-talk between notch and the estrogen receptor in breast cancer suggests novel therapeutic approaches. (Rizzo P, Miao H, D'Souza G, Osipo C, Song LL, Yun J, Zhao H, Mascarenhas J, Wyatt D, Antico G, Hao L, Yao K, Rajan P, Hicks C, Siziopikou K, Selvaggi S, Bashir A, Bhandari D, Marchese A, Lendahl U, Qin JZ, Tonetti DA, Albain K, Nickoloff BJ, Miele L) Cancer Res 2008 Jul 01;68(13):5226-35 PMID: 18593923 PMCID: PMC4445363 07/03/2008       233 Citations
  • G protein-coupled receptor sorting to endosomes and lysosomes. (Marchese A, Paing MM, Temple BR, Trejo J) Annu Rev Pharmacol Toxicol 2008;48:601-29 PMID: 17995450 PMCID: PMC2869288 11/13/2007       301 Citations
  • Arrestin-2 interacts with the ubiquitin-protein isopeptide ligase atrophin-interacting protein 4 and mediates endosomal sorting of the chemokine receptor CXCR4. (Bhandari D, Trejo J, Benovic JL, Marchese A) J Biol Chem 2007 Dec 21;282(51):36971-9 PMID: 17947233 10/20/2007       142 Citations
  • Ubiquitination differentially regulates clathrin-dependent internalization of protease-activated receptor-1. (Wolfe BL, Marchese A, Trejo J) J Cell Biol 2007 Jun 04;177(5):905-16 PMID: 17535965 PMCID: PMC2064289 05/31/2007       76 Citations
  • CISK attenuates degradation of the chemokine receptor CXCR4 via the ubiquitin ligase AIP4. (Slagsvold T, Marchese A, Brech A, Stenmark H) EMBO J 2006 Aug 23;25(16):3738-49 PMID: 16888620 PMCID: PMC1553197 08/05/2006       45 Citations
  • Assessment of degradation and ubiquitination of CXCR4, a GPCR regulated by EGFR family members. (Marchese A) Methods Mol Biol 2006;327:139-45 PMID: 16780218 06/20/2006       7 Citations
  • A new key in breast cancer metastasis. (Benovic JL, Marchese A) Cancer Cell 2004 Nov;6(5):429-30 PMID: 15542424 11/16/2004       31 Citations
  • Ubiquitination of G-protein-coupled receptors. (Marchese A, Benovic JL) Methods Mol Biol 2004;259:299-305 PMID: 15250500 07/15/2004       11 Citations
  • The E3 ubiquitin ligase AIP4 mediates ubiquitination and sorting of the G protein-coupled receptor CXCR4. (Marchese A, Raiborg C, Santini F, Keen JH, Stenmark H, Benovic JL) Dev Cell 2003 Nov;5(5):709-22 PMID: 14602072 11/07/2003       266 Citations
  • The ins and outs of G protein-coupled receptor trafficking. (Marchese A, Chen C, Kim YM, Benovic JL) Trends Biochem Sci 2003 Jul;28(7):369-76 PMID: 12878004 07/25/2003       157 Citations
  • The Grb10/Nedd4 complex regulates ligand-induced ubiquitination and stability of the insulin-like growth factor I receptor. (Vecchione A, Marchese A, Henry P, Rotin D, Morrione A) Mol Cell Biol 2003 May;23(9):3363-72 PMID: 12697834 PMCID: PMC153198 04/17/2003       182 Citations
  • Last update: 07/30/2018
    jenkins-FCD Prod-300 626508253d14e4184314fb9f66322a03a5906796