Medical College of Wisconsin
CTSICores SearchResearch InformaticsREDCap

Albert W. Girotti PhD

Albert W. Girotti PhD

Adjunct Professor

Institution: Medical College of Wisconsin
Department: Biochemistry

Member of the Cancer Center
Member of the Cardiovascular Center


Publications

  • Is Photodynamic Therapy Resistance a Special Case of Photobiomodulation? (Quirk BJ, Girotti AW, Whelan HT) Photomed Laser Surg 2018 08;36(8):397-398 PMID: 30089080 08/09/2018    
  • Cholesterol Peroxidation as a Special Type of Lipid Oxidation in Photodynamic Systems. (Girotti AW, Korytowski W) Photochem Photobiol 2018 Jul 01 PMID: 29962109 PMCID: PMC6312749 07/03/2018    
  • Upregulation of nitric oxide in tumor cells as a negative adaptation to photodynamic therapy. (Girotti AW) Lasers Surg Med 2018 Jul;50(5):590-598 PMID: 29504635 03/06/2018    
  • Nitric oxide antagonism to glioblastoma photodynamic therapy and mitigation thereof by BET bromodomain inhibitor JQ1. (Fahey JM, Stancill JS, Smith BC, Girotti AW) J Biol Chem 2018 04 06;293(14):5345-5359 PMID: 29440272 PMCID: PMC5892570 02/15/2018       1 Citations
  • Bystander effects of nitric oxide in anti-tumor photodynamic therapy. (Bazak J, Fahey JM, Wawak K, Korytowski W, Girotti AW) Cancer Cell Microenviron 2017;4(1) PMID: 29201944 PMCID: PMC5708575 12/05/2017    
  • Cholesterol Hydroperoxide Generation, Translocation, and Reductive Turnover in Biological Systems. (Girotti AW, Korytowski W) Cell Biochem Biophys 2017 Dec;75(3-4):413-419 PMID: 28434137 PMCID: PMC5651211 04/24/2017       3 Citations
  • Bystander effects of nitric oxide in anti-tumor photodynamic therapy (J. Bazak, J.M. Fahey, K. Wawak, W. Korytowski, A.W. Girotti) Cancer Cell Microenvironment 4:e1511.doi:10.14800/ccm.1511 03/28/2017    
  • Nitric oxide-mediated resistance to photodynamic therapy in a human breast tumor xenograft model: Improved outcome with NOS2 inhibitors. (Fahey JM, Girotti AW) Nitric Oxide 2017 Jan 30;62:52-61 PMID: 28007662 PMCID: PMC5215003 12/23/2016       8 Citations
  • Enhanced aggressiveness of bystander cells in an anti-tumor photodynamic therapy model: Role of nitric oxide produced by targeted cells. (Bazak J, Fahey JM, Wawak K, Korytowski W, Girotti AW) Free Radic Biol Med 2017 01;102:111-121 PMID: 27884704 11/26/2016       7 Citations
  • Multiple Means by Which Nitric Oxide can Antagonize Photodynamic Therapy. (Girotti AW, Fahey JM, Korytowski W) Curr Med Chem 2016;23(24):2754-2769 PMID: 27776475 10/26/2016       7 Citations
  • Modulation of the Anti-Tumor Efficacy of Photodynamic Therapy by Nitric Oxide. (Girotti AW) Cancers (Basel) 2016 Oct 20;8(10) PMID: 27775600 PMCID: PMC5082386 10/25/2016    
  • Antagonistic Effects of Endogenous Nitric Oxide in a Glioblastoma Photodynamic Therapy Model. (Fahey JM, Emmer JV, Korytowski W, Hogg N, Girotti AW) Photochem Photobiol 2016 11;92(6):842-853 PMID: 27608331 PMCID: PMC5161550 09/09/2016       7 Citations
  • Cholesterol as a natural probe for free radical-mediated lipid peroxidation in biological membranes and lipoproteins. (Girotti AW, Korytowski W) J Chromatogr B Analyt Technol Biomed Life Sci 2016 Apr 15;1019:202-9 PMID: 26778710 PMCID: PMC4829455 01/19/2016       5 Citations
  • Role of Endogenous Nitric Oxide in Hyperaggressiveness of Tumor Cells that Survive a Photodynamic Therapy Challenge. (Girotti AW) Crit Rev Oncog 2016;21(5-6):353-363 PMID: 29431083 PMCID: PMC5963268 01/01/2016    
  • Impairment of Macrophage Cholesterol Efflux by Cholesterol Hydroperoxide Trafficking: Implications for Atherogenesis Under Oxidative Stress. (Korytowski W, Wawak K, Pabisz P, Schmitt JC, Chadwick AC, Sahoo D, Girotti AW) Arterioscler Thromb Vasc Biol 2015 Oct;35(10):2104-13 PMID: 26315403 PMCID: PMC4601804 09/01/2015       13 Citations
  • Accelerated migration and invasion of prostate cancer cells after a photodynamic therapy-like challenge: Role of nitric oxide. (Fahey JM, Girotti AW) Nitric Oxide 2015 Sep 15;49:47-55 PMID: 26068242 PMCID: PMC4545398 06/13/2015       20 Citations
  • Photodynamic therapy (PDT) for malignant brain tumors--where do we stand? (Quirk BJ, Brandal G, Donlon S, Vera JC, Mang TS, Foy AB, Lew SM, Girotti AW, Jogal S, LaViolette PS, Connelly JM, Whelan HT) Photodiagnosis Photodyn Ther 2015 Sep;12(3):530-44 PMID: 25960361 05/12/2015       62 Citations
  • Tumor-generated nitric oxide as an antagonist of photodynamic therapy. (Girotti AW) Photochem Photobiol Sci 2015 Aug;14(8):1425-32 PMID: 25706541 02/24/2015       4 Citations
  • Binding and cytotoxic trafficking of cholesterol hydroperoxides by sterol carrier protein-2. (Girotti AW, Kriska T) Methods Mol Biol 2015;1208:421-35 PMID: 25323524 10/18/2014       1 Citations
  • Regulation of ferroptotic cancer cell death by GPX4. (Yang WS, SriRamaratnam R, Welsch ME, Shimada K, Skouta R, Viswanathan VS, Cheah JH, Clemons PA, Shamji AF, Clish CB, Brown LM, Girotti AW, Cornish VW, Schreiber SL, Stockwell BR) Cell 2014 Jan 16;156(1-2):317-331 PMID: 24439385 PMCID: PMC4076414 01/21/2014       380 Citations
  • Macrophage mitochondrial damage from StAR transport of 7-hydroperoxycholesterol: implications for oxidative stress-impaired reverse cholesterol transport. (Korytowski W, Wawak K, Pabisz P, Schmitt JC, Girotti AW) FEBS Lett 2014 Jan 03;588(1):65-70 PMID: 24269887 11/26/2013       10 Citations
  • Pro-survival and pro-growth effects of stress-induced nitric oxide in a prostate cancer photodynamic therapy model. (Bhowmick R, Girotti AW) Cancer Lett 2014 Feb 01;343(1):115-22 PMID: 24080338 PMCID: PMC3874260 10/02/2013    
  • Development of a tumor-specific photoactivatable doxorubicin prodrug. (Girotti AW, Minotti G) Photochem Photobiol 2013 Sep-Oct;89(5):1009-10 PMID: 23944612 PMCID: PMC3817842 08/16/2013       2 Citations
  • Deleterious cholesterol hydroperoxide trafficking in steroidogenic acute regulatory (StAR) protein-expressing MA-10 Leydig cells: implications for oxidative stress-impaired steroidogenesis. (Korytowski W, Pilat A, Schmitt JC, Girotti AW) J Biol Chem 2013 Apr 19;288(16):11509-19 PMID: 23467407 PMCID: PMC3630865 03/08/2013       13 Citations
  • Cytoprotective signaling associated with nitric oxide upregulation in tumor cells subjected to photodynamic therapy-like oxidative stress. (Bhowmick R, Girotti AW) Free Radic Biol Med 2013 Apr;57:39-48 PMID: 23261943 PMCID: PMC3594367 12/25/2012       36 Citations
  • Relationship between oxidizable fatty acid content and level of antioxidant glutathione peroxidases in marine fish. (Grim JM, Hyndman KA, Kriska T, Girotti AW, Crockett EL) J Exp Biol 2011 Nov 15;214(Pt 22):3751-9 PMID: 22031739 PMCID: PMC3202513 10/28/2011       14 Citations
  • Permeabilization of the mitochondrial outer membrane by Bax/truncated Bid (tBid) proteins as sensitized by cardiolipin hydroperoxide translocation: mechanistic implications for the intrinsic pathway of oxidative apoptosis. (Korytowski W, Basova LV, Pilat A, Kernstock RM, Girotti AW) J Biol Chem 2011 Jul 29;286(30):26334-43 PMID: 21642428 PMCID: PMC3143596 06/07/2011       59 Citations
  • Photodynamic therapy of cancer: an update. (Agostinis P, Berg K, Cengel KA, Foster TH, Girotti AW, Gollnick SO, Hahn SM, Hamblin MR, Juzeniene A, Kessel D, Korbelik M, Moan J, Mroz P, Nowis D, Piette J, Wilson BC, Golab J) CA Cancer J Clin 2011 Jul-Aug;61(4):250-81 PMID: 21617154 PMCID: PMC3209659 05/28/2011       1615 Citations
  • Rapid upregulation of cytoprotective nitric oxide in breast tumor cells subjected to a photodynamic therapy-like oxidative challenge. (Bhowmick R, Girotti AW) Photochem Photobiol 2011 Mar-Apr;87(2):378-86 PMID: 21143607 PMCID: PMC3048913 12/15/2010       22 Citations
  • Introduction to the symposium-in-print: photobiology of the skin and eye in memory of Colin F. Chignell. (Roberts JE, Girotti AW, Buettner GR, He YY) Photochem Photobiol 2010 Jul-Aug;86(4):740-1 PMID: 20653881 07/27/2010    
  • Sterol carrier protein-2 (SCP-2) involvement in cholesterol hydroperoxide cytotoxicity as revealed by SCP-2 inhibitor effects. (Kriska T, Pilat A, Schmitt JC, Girotti AW) J Lipid Res 2010 Nov;51(11):3174-84 PMID: 20656919 PMCID: PMC2952558 07/27/2010       13 Citations
  • Surprising inability of singlet oxygen-generated 6-hydroperoxycholesterol to induce damaging free radical lipid peroxidation in cell membranes. (Korytowski W, Schmitt JC, Girotti AW) Photochem Photobiol 2010 Jul-Aug;86(4):747-51 PMID: 20408976 PMCID: PMC2910147 04/23/2010       13 Citations
  • Apoptosis-accommodating effect of nitric oxide in photodynamically stressed tumor cells. (Niziolek-Kierecka M, Pilat A, Korytowski W, Girotti AW) Photochem Photobiol 2010 May-Jun;86(3):681-6 PMID: 20331521 03/25/2010       7 Citations
  • Cytoprotective induction of nitric oxide synthase in a cellular model of 5-aminolevulinic acid-based photodynamic therapy. (Bhowmick R, Girotti AW) Free Radic Biol Med 2010 May 15;48(10):1296-301 PMID: 20138143 PMCID: PMC2856718 02/09/2010       43 Citations
  • StarD4-mediated translocation of 7-hydroperoxycholesterol to isolated mitochondria: deleterious effects and implications for steroidogenesis under oxidative stress conditions. (Korytowski W, Rodriguez-Agudo D, Pilat A, Girotti AW) Biochem Biophys Res Commun 2010 Jan 29;392(1):58-62 PMID: 20059974 PMCID: PMC2829839 01/12/2010       16 Citations
  • Signaling events in apoptotic photokilling of 5-aminolevulinic acid-treated tumor cells: inhibitory effects of nitric oxide. (Bhowmick R, Girotti AW) Free Radic Biol Med 2009 Sep 15;47(6):731-40 PMID: 19524035 PMCID: PMC2761093 06/16/2009       27 Citations
  • New strategies for the isolation and activity determination of naturally occurring type-4 glutathione peroxidase. (Kernstock RM, Girotti AW) Protein Expr Purif 2008 Dec;62(2):216-22 PMID: 18723092 PMCID: PMC2587134 08/30/2008       6 Citations
  • Novel enrichment of tumor cell transfectants expressing high levels of type 4 glutathione peroxidase using 7alpha-hydroperoxycholesterol as a selection agent. (Kriska T, Levchenko VV, Chu FF, Esworthy RS, Girotti AW) Free Radic Biol Med 2008 Sep 01;45(5):700-7 PMID: 18554519 PMCID: PMC2603420 06/17/2008       3 Citations
  • Translocation as a means of disseminating lipid hydroperoxide-induced oxidative damage and effector action. (Girotti AW) Free Radic Biol Med 2008 Mar 15;44(6):956-68 PMID: 18206663 PMCID: PMC2361152 01/22/2008       62 Citations
  • Lipid transfer protein binding of unmodified natural lipids as assessed by surface plasmon resonance methodology. (Kernstock RM, Girotti AW) Anal Biochem 2007 Jun 01;365(1):111-21 PMID: 17376396 PMCID: PMC1975857 03/23/2007       8 Citations
  • Phospholipase action of platelet-activating factor acetylhydrolase, but not paraoxonase-1, on long fatty acyl chain phospholipid hydroperoxides. (Kriska T, Marathe GK, Schmidt JC, McIntyre TM, Girotti AW) J Biol Chem 2007 Jan 05;282(1):100-8 PMID: 17090529 11/09/2006       50 Citations
  • Intracellular dissemination of peroxidative stress. Internalization, transport, and lethal targeting of a cholesterol hydroperoxide species by sterol carrier protein-2-overexpressing hepatoma cells. (Kriska T, Levchenko VV, Korytowski W, Atshaves BP, Schroeder F, Girotti AW) J Biol Chem 2006 Aug 18;281(33):23643-51 PMID: 16772292 06/15/2006       25 Citations
  • Nitric oxide-induced resistance to lethal photooxidative damage in a breast tumor cell line. (Niziolek M, Korytowski W, Girotti AW) Free Radic Biol Med 2006 Apr 15;40(8):1323-31 PMID: 16631522 04/25/2006       28 Citations
  • Separation and quantitation of phospholipid hydroperoxide families using high-performance liquid chromatography with mercury cathode electrochemical detection. (Korytowski W, Niziolek M, Girotti AW) Anal Biochem 2005 Aug 01;343(1):136-42 PMID: 15979556 06/28/2005       6 Citations
  • A thin layer chromatographic method for determining the enzymatic activity of peroxidases catalyzing the two-electron reduction of lipid hydroperoxides. (Kriska T, Girotti AW) J Chromatogr B Analyt Technol Biomed Life Sci 2005 Nov 15;827(1):58-64 PMID: 15899595 05/19/2005       7 Citations
  • Merocyanine 540-sensitized photokilling of leukemia cells: role of post-irradiation chain peroxidation of plasma membrane lipids as revealed by nitric oxide protection. (Zareba M, Niziolek M, Korytowski W, Girotti AW) Biochim Biophys Acta 2005 Feb 11;1722(1):51-9 PMID: 15716134 02/18/2005       10 Citations
  • Self-sensitized photodegradation of membrane-bound protoporphyrin mediated by chain lipid peroxidation: inhibition by nitric oxide with sustained singlet oxygen damage. (Niziolek M, Korytowski W, Girotti AW) Photochem Photobiol 2005 Mar-Apr;81(2):299-305 PMID: 15647001 01/14/2005       12 Citations
  • Role of mitochondrial cardiolipin peroxidation in apoptotic photokilling of 5-aminolevulinate-treated tumor cells. (Kriska T, Korytowski W, Girotti AW) Arch Biochem Biophys 2005 Jan 15;433(2):435-46 PMID: 15581600 12/08/2004       69 Citations
  • Sterol carrier protein-2-facilitated intermembrane transfer of cholesterol- and phospholipid-derived hydroperoxides. (Vila A, Levchenko VV, Korytowski W, Girotti AW) Biochemistry 2004 Oct 05;43(39):12592-605 PMID: 15449949 09/29/2004       32 Citations
  • Separation and quantitation of peroxidized phospholipids using high-performance thin-layer chromatography with tetramethyl-p-phenylenediamine detection. (Kriska T, Girotti AW) Anal Biochem 2004 Apr 01;327(1):97-106 PMID: 15033516 03/23/2004       17 Citations
  • Role of lipid hydroperoxides in photo-oxidative stress signaling. (Girotti AW, Kriska T) Antioxid Redox Signal 2004 Apr;6(2):301-10 PMID: 15025931 03/18/2004       102 Citations
  • Chain-breaking antioxidant and cytoprotective action of nitric oxide on photodynamically stressed tumor cells. (Niziolek M, Korytowski W, Girotti AW) Photochem Photobiol 2003 Sep;78(3):262-70 PMID: 14556313 10/15/2003       37 Citations
  • Nitric oxide inhibition of free radical-mediated lipid peroxidation in photodynamically treated membranes and cells. (Niziolek M, Korytowski W, Girotti AW) Free Radic Biol Med 2003 Apr 15;34(8):997-1005 PMID: 12684084 04/10/2003       28 Citations
  • Spontaneous transfer of phospholipid and cholesterol hydroperoxides between cell membranes and low-density lipoprotein: assessment of reaction kinetics and prooxidant effects. (Vila A, Korytowski W, Girotti AW) Biochemistry 2002 Nov 19;41(46):13705-16 PMID: 12427033 11/13/2002       34 Citations
  • Hyperresistance to photosensitized lipid peroxidation and apoptotic killing in 5-aminolevulinate-treated tumor cells overexpressing mitochondrial GPX4. (Kriska T, Korytowski W, Girotti AW) Free Radic Biol Med 2002 Nov 15;33(10):1389-402 PMID: 12419471 11/07/2002       45 Citations
  • Spontaneous intermembrane transfer of various cholesterol-derived hydroperoxide species: kinetic studies with model membranes and cells. (Vila A, Korytowski W, Girotti AW) Biochemistry 2001 Dec 04;40(48):14715-26 PMID: 11724586 11/29/2001       35 Citations
  • Photosensitized oxidation of membrane lipids: reaction pathways, cytotoxic effects, and cytoprotective mechanisms. (Girotti AW) J Photochem Photobiol B 2001 Oct;63(1-3):103-13 PMID: 11684457 10/31/2001       381 Citations
  • Hyperresistance to cholesterol hydroperoxide-induced peroxidative injury and apoptotic death in a tumor cell line that overexpresses glutathione peroxidase isotype-4. (Hurst R, Korytowski W, Kriska T, Esworthy RS, Chu FF, Girotti AW) Free Radic Biol Med 2001 Nov 01;31(9):1051-65 PMID: 11677038 10/26/2001       48 Citations
  • Inhibition of free radical-mediated cholesterol peroxidation by diazeniumdiolate-derived nitric oxide: effect of release rate on mechanism of action in a membrane system. (Korytowski W, Zareba M, Girotti AW) Chem Res Toxicol 2000 Dec;13(12):1265-74 PMID: 11123968 12/22/2000       17 Citations
  • Cholesterol as a singlet oxygen detector in biological systems. (Girotti AW, Korytowski W) Methods Enzymol 2000;319:85-100 PMID: 10907502 07/25/2000       66 Citations
  • Dissemination of peroxidative stress via intermembrane transfer of lipid hydroperoxides: model studies with cholesterol hydroperoxides. (Vila A, Korytowski W, Girotti AW) Arch Biochem Biophys 2000 Aug 01;380(1):208-18 PMID: 10900151 07/20/2000       27 Citations
  • Nitric oxide inhibition of free radical-mediated cholesterol peroxidation in liposomal membranes. (Korytowski W, Zareba M, Girotti AW) Biochemistry 2000 Jun 13;39(23):6918-28 PMID: 10841773 06/08/2000       22 Citations
  • Singlet oxygen adducts of cholesterol: photogeneration and reductive turnover in membrane systems. (Korytowski W, Girotti AW) Photochem Photobiol 1999 Oct;70(4):484-9 PMID: 10546545 11/05/1999       44 Citations
  • Low-density lipoprotein susceptibility to oxidation and cytotoxicity to endothelium in sickle cell anemia. (Belcher JD, Marker PH, Geiger P, Girotti AW, Steinberg MH, Hebbel RP, Vercellotti GM) J Lab Clin Med 1999 Jun;133(6):605-12 PMID: 10360636 06/09/1999       22 Citations
  • Radiolabeled cholesterol as a reporter for assessing one-electron turnover of lipid hydroperoxides. (Korytowski W, Wrona M, Girotti AW) Anal Biochem 1999 May 15;270(1):123-32 PMID: 10328773 05/18/1999       39 Citations
  • Protoporphyrin IX-sensitized photoinactivation of 5-aminolevulinate-treated leukemia cells: effects of exogenous iron. (Lin F, Geiger PG, Korytowski W, Girotti AW) Photochem Photobiol 1999 Mar;69(3):375-81 PMID: 10089831 03/25/1999       5 Citations
  • Lipid hydroperoxide analysis by high-performance liquid chromatography with mercury cathode electrochemical detection. (Korytowski W, Geiger PG, Girotti AW) Methods Enzymol 1999;300:23-33 PMID: 9919505 01/27/1999       47 Citations
  • Delayed hyperresistance of endothelial cells to photodynamic inactivation after contact with hemin. (Lin F, Bertling CJ, Geiger PG, Girotti AW) Photochem Photobiol 1998 Aug;68(2):211-7 PMID: 9723213 09/02/1998       5 Citations
  • Lipid hydroperoxide generation, turnover, and effector action in biological systems. (Girotti AW) J Lipid Res 1998 Aug;39(8):1529-42 PMID: 9717713 08/26/1998       837 Citations
  • Hemin-enhanced resistance of human leukemia cells to oxidative killing: antisense determination of ferritin involvement. (Lin F, Girotti AW) Arch Biochem Biophys 1998 Apr 01;352(1):51-8 PMID: 9521813 05/09/1998       44 Citations
  • Elevated ferritin production, iron containment, and oxidant resistance in hemin-treated leukemia cells. (Lin F, Girotti AW) Arch Biochem Biophys 1997 Oct 01;346(1):131-41 PMID: 9328293 11/05/1997       33 Citations
  • Lipid peroxidation in photodynamically stressed mammalian cells: use of cholesterol hydroperoxides as mechanistic reporters. (Geiger PG, Korytowski W, Lin F, Girotti AW) Free Radic Biol Med 1997;23(1):57-68 PMID: 9165297 01/01/1997       45 Citations
  • Hyperresistance of leukemia cells to photodynamic inactivation after long-term exposure to hemin. (Lin F, Girotti AW) Cancer Res 1996 Oct 15;56(20):4636-43 PMID: 8840977 10/15/1996       24 Citations
  • Enzymatic reducibility in relation to cytotoxicity for various cholesterol hydroperoxides. (Korytowski W, Geiger PG, Girotti AW) Biochemistry 1996 Jul 02;35(26):8670-9 PMID: 8679629 07/02/1996       31 Citations
  • Role of hydrogen peroxide in the cytotoxic effects of UVA/B radiation on mammalian cells. (Bertling CJ, Lin F, Girotti AW) Photochem Photobiol 1996 Jul;64(1):137-42 PMID: 8787007 07/01/1996       41 Citations
  • Photodynamically generated 3-beta-hydroxy-5 alpha-cholest-6-ene-5- hydroperoxide: toxic reactivity in membranes and susceptibility to enzymatic detoxification. (Geiger PG, Korytowski W, Girotti AW) Photochem Photobiol 1995 Sep;62(3):580-7 PMID: 8570716 09/01/1995       32 Citations
  • Stimulatory and inhibitory effects of iron on photodynamic inactivation of leukemia cells. (Lin F, Girotti AW) Photochem Photobiol 1995 Sep;62(3):528-34 PMID: 8570708 09/01/1995       7 Citations
  • High-performance liquid chromatography with mercury cathode electrochemical detection: application to lipid hydroperoxide analysis. (Korytowski W, Geiger PG, Girotti AW) J Chromatogr B Biomed Appl 1995 Aug 18;670(2):189-97 PMID: 8548009 08/18/1995       42 Citations
  • Selenoperoxidase-dependent glutathione cycle activity in peroxide-challenged leukemia cells. (Korytowski W, Bachowski GJ, Geiger PG, Lin F, Zhao G, Girotti AW) Biochim Biophys Acta 1995 May 29;1267(1):31-40 PMID: 7779866 05/29/1995       9 Citations
  • Amplification and hyperexpression of the catalase gene in selenoperoxidase-deficient leukemia cells. (Lin F, Jackson VE, Girotti AW) Arch Biochem Biophys 1995 Feb 20;317(1):7-18 PMID: 7872806 02/20/1995    
  • Involvement of preexisting lipid hydroperoxides in Cu(2+)-stimulated oxidation of low-density lipoprotein. (Thomas JP, Kalyanaraman B, Girotti AW) Arch Biochem Biophys 1994 Dec;315(2):244-54 PMID: 7986064 12/01/1994    
  • Characterization of lipid hydroperoxides generated by photodynamic treatment of leukemia cells. (Bachowski GJ, Korytowski W, Girotti AW) Lipids 1994 Jul;29(7):449-59 PMID: 7968265 07/01/1994       32 Citations
  • Bleaching of membrane-bound merocyanine 540 in conjunction with free radical-mediated lipid peroxidation. (Pintar TJ, Lin F, Girotti AW) Free Radic Biol Med 1994 May;16(5):603-12 PMID: 8026803 05/01/1994       10 Citations
  • Cytoprotection against merocyanine 540-sensitized photoinactivation of the Na+,K(+)-adenosine triphosphatase in leukemia cells: glutathione and selenoperoxidase involvement. (Lin F, Girotti AW) Photochem Photobiol 1994 Mar;59(3):320-7 PMID: 8016211 03/01/1994       5 Citations
  • Reactivity of plasma glutathione peroxidase with hydroperoxide substrates and glutathione. (Esworthy RS, Chu FF, Geiger P, Girotti AW, Doroshow JH) Arch Biochem Biophys 1993 Nov 15;307(1):29-34 PMID: 8239661 11/15/1993    
  • Hyperexpression of catalase in selenium-deprived murine L1210 cells. (Lin F, Thomas JP, Girotti AW) Arch Biochem Biophys 1993 Aug 15;305(1):176-85 PMID: 8342949 08/15/1993    
  • Analysis of cholesterol and phospholipid hydroperoxides by high-performance liquid chromatography with mercury drop electrochemical detection. (Korytowski W, Bachowski GJ, Girotti AW) Anal Biochem 1993 Aug 15;213(1):111-9 PMID: 8238862 08/15/1993    
  • Lethal damage to endothelial cells by oxidized low density lipoprotein: role of selenoperoxidases in cytoprotection against lipid hydroperoxide- and iron-mediated reactions. (Thomas JP, Geiger PG, Girotti AW) J Lipid Res 1993 Mar;34(3):479-90 PMID: 8468531 03/01/1993       127 Citations
  • Selenoperoxidase-mediated cytoprotection against the damaging effects of tert-butyl hydroperoxide on leukemia cells. (Geiger PG, Lin F, Girotti AW) Free Radic Biol Med 1993 Mar;14(3):251-66 PMID: 8458583 03/01/1993       50 Citations
  • Photodynamic action of merocyanine 540 on leukemia cells: iron-stimulated lipid peroxidation and cell killing. (Lin F, Girotti AW) Arch Biochem Biophys 1993 Feb 01;300(2):714-23 PMID: 8434951 02/01/1993    
  • Selenoperoxidase-mediated cytoprotection against merocyanine 540-sensitized photoperoxidation and photokilling of leukemia cells. (Lin F, Geiger PG, Girotti AW) Cancer Res 1992 Oct 01;52(19):5282-90 PMID: 1394132 10/01/1992       49 Citations
  • Photoperoxidation of cholesterol in homogeneous solution, isolated membranes, and cells: comparison of the 5 alpha- and 6 beta-hydroperoxides as indicators of singlet oxygen intermediacy. (Korytowski W, Bachowski GJ, Girotti AW) Photochem Photobiol 1992 Jul;56(1):1-8 PMID: 1508976 07/01/1992       77 Citations
  • Photosensitized oxidation of cholesterol in biological systems: reaction pathways, cytotoxic effects and defense mechanisms. (Girotti AW) J Photochem Photobiol B 1992 Apr 30;13(2):105-18 PMID: 1506985 04/30/1992       77 Citations
  • Photodynamic action of merocyanine 540 on erythrocyte membranes: structural perturbation of lipid and protein constituents. (Feix JB, Bachowski GJ, Girotti AW) Biochim Biophys Acta 1991 Sep 02;1075(1):28-35 PMID: 1654108 09/02/1991       50 Citations
  • Chromatographic separation and electrochemical determination of cholesterol hydroperoxides generated by photodynamic action. (Korytowski W, Bachowski GJ, Girotti AW) Anal Biochem 1991 Aug 15;197(1):149-56 PMID: 1952058 08/15/1991       71 Citations
  • Lethal damage to murine L1210 cells by exogenous lipid hydroperoxides: protective role of glutathione-dependent selenoperoxidases. (Geiger PG, Thomas JP, Girotti AW) Arch Biochem Biophys 1991 Aug 01;288(2):671-80 PMID: 1898056 08/01/1991       42 Citations
  • Phthalocyanine-sensitized lipid peroxidation in cell membranes: use of cholesterol and azide as probes of primary photochemistry. (Bachowski GJ, Ben-Hur E, Girotti AW) J Photochem Photobiol B 1991 Jun;9(3-4):307-21 PMID: 1919874 06/01/1991       37 Citations
  • Photodynamic action of merocyanine 540 in artificial bilayers and natural membranes: action spectra and quantum yields. (Singh RJ, Feix JB, Pintar TJ, Girotti AW, Kalyanaraman B) Photochem Photobiol 1991 Apr;53(4):493-500 PMID: 1857744 04/01/1991       37 Citations
  • Photosensitized lipid peroxidation and enzyme inactivation by membrane-bound merocyanine 540: reaction mechanisms in the absence and presence of ascorbate. (Bachowski GJ, Pintar TJ, Girotti AW) Photochem Photobiol 1991 Apr;53(4):481-91 PMID: 1857743 04/01/1991       54 Citations
  • Reactivity of phospholipid hydroperoxide glutathione peroxidase with membrane and lipoprotein lipid hydroperoxides. (Maiorino M, Thomas JP, Girotti AW, Ursini F) Free Radic Res Commun 1991;12-13 Pt 1:131-5 PMID: 2071029 01/01/1991       64 Citations
  • Enzymatic reduction of phospholipid and cholesterol hydroperoxides in artificial bilayers and lipoproteins. (Thomas JP, Geiger PG, Maiorino M, Ursini F, Girotti AW) Biochim Biophys Acta 1990 Aug 06;1045(3):252-60 PMID: 2386798 08/06/1990       93 Citations
  • Photodynamic lipid peroxidation in biological systems. (Girotti AW) Photochem Photobiol 1990 Apr;51(4):497-509 PMID: 2188273 04/01/1990       434 Citations
  • Protective action of phospholipid hydroperoxide glutathione peroxidase against membrane-damaging lipid peroxidation. In situ reduction of phospholipid and cholesterol hydroperoxides. (Thomas JP, Maiorino M, Ursini F, Girotti AW) J Biol Chem 1990 Jan 05;265(1):454-61 PMID: 2294113 01/05/1990       403 Citations
  • Role of lipid peroxidation in hematoporphyrin derivative-sensitized photokilling of tumor cells: protective effects of glutathione peroxidase. (Thomas JP, Girotti AW) Cancer Res 1989 Apr 01;49(7):1682-6 PMID: 2522345 04/01/1989       65 Citations
  • Glucose administration augments in vivo uptake and phototoxicity of the tumor-localizing fraction of hematoporphyrin derivative. (Thomas JP, Girotti AW) Photochem Photobiol 1989 Mar;49(3):241-7 PMID: 2525259 03/01/1989       66 Citations
  • Reactivity of photochemically-generated lipid hydroperoxides in cell membranes with glutathione peroxidase. (Thomas JP, Girotti AW) Photochem Photobiol 1989 Feb;49(2):153-6 PMID: 2523541 02/01/1989       17 Citations
  • Photooxidation of cell membranes in the presence of hematoporphyrin derivative: reactivity of phospholipid and cholesterol hydroperoxides with glutathione peroxidase. (Thomas JP, Girotti AW) Biochim Biophys Acta 1988 Oct 14;962(3):297-307 PMID: 2971397 10/14/1988       48 Citations
  • Ascorbate-enhanced lipid peroxidation in photooxidized cell membranes: cholesterol product analysis as a probe of reaction mechanism. (Bachowski GJ, Thomas JP, Girotti AW) Lipids 1988 Jun;23(6):580-6 PMID: 3172988 06/01/1988       46 Citations
  • Porphyrin-sensitized photoreactions in the presence of ascorbate: oxidation of cell membrane lipids and hydroxyl radical traps. (Bachowski GJ, Morehouse KM, Girotti AW) Photochem Photobiol 1988 May;47(5):635-45 PMID: 2841702 05/01/1988       25 Citations
  • Light-stimulated formation of hydrogen peroxide and hydroxyl radical in the presence of uroporphyrin and ascorbate. (Bachowski GJ, Girotti AW) Free Radic Biol Med 1988;5(1):3-6 PMID: 2855416 01/01/1988       15 Citations
  • Lipid peroxidation in erythrocyte membranes: cholesterol product analysis in photosensitized and xanthine oxidase-catalyzed reactions. (Girotti AW, Bachowski GJ, Jordan JE) Lipids 1987 Jun;22(6):401-8 PMID: 3112484 06/01/1987       23 Citations
  • Singlet oxygen intermediacy in the photodynamic action of membrane-bound hematoporphyrin derivative. (Thomas JP, Hall RD, Girotti AW) Cancer Lett 1987 Jun;35(3):295-302 PMID: 2954632 06/01/1987       62 Citations
  • Photodynamic action of merocyanine 540 on artificial and natural cell membranes: involvement of singlet molecular oxygen. (Kalyanaraman B, Feix JB, Sieber F, Thomas JP, Girotti AW) Proc Natl Acad Sci U S A 1987 May;84(9):2999-3003 PMID: 3033673 PMCID: PMC304788 05/01/1987       163 Citations
  • Inhibition of cell membrane lipid peroxidation by cadmium- and zinc-metallothioneins. (Thomas JP, Bachowski GJ, Girotti AW) Biochim Biophys Acta 1986 Dec 10;884(3):448-61 PMID: 3778934 12/10/1986       207 Citations
  • Xanthine oxidase-catalyzed crosslinking of cell membrane proteins. (Girotti AW, Thomas JP, Jordan JE) Arch Biochem Biophys 1986 Dec;251(2):639-53 PMID: 3800391 12/01/1986       43 Citations
  • Photohemolysis of human erythrocytes labeled in band 3 with eosin-isothiocyanate. (Pooler JP, Girotti AW) Photochem Photobiol 1986 Oct;44(4):495-9 PMID: 2431425 10/01/1986       27 Citations
  • Prooxidant and antioxidant effects of ascorbate on photosensitized peroxidation of lipids in erythrocyte membranes. (Girotti AW, Thomas JP, Jordan JE) Photochem Photobiol 1985 Mar;41(3):267-76 PMID: 4011692 03/01/1985       59 Citations
  • Phototoxic effects of hematoporphyrin derivative and its chromatographic fractions on hormone-producing human malignant trophoblast cells in vitro. (Girotti AW, Hussa RO) Adv Exp Med Biol 1985;193:129-45 PMID: 2937259 01/01/1985       3 Citations
  • Lipid photooxidation in erythrocyte ghosts: sensitization of the membranes toward ascorbate- and superoxide-induced peroxidation and lysis. (Girotti AW, Thomas JP, Jordan JE) Arch Biochem Biophys 1985 Jan;236(1):238-51 PMID: 2981506 01/01/1985       65 Citations
  • Mechanisms of lipid peroxidation. (Girotti AW) J Free Radic Biol Med 1985;1(2):87-95 PMID: 3915303 01/01/1985       412 Citations
  • Inhibitory effect of zinc(II) on free radical lipid peroxidation in erythrocyte membranes. (Girotti AW, Thomas JP, Jordan JE) J Free Radic Biol Med 1985;1(5-6):395-401 PMID: 3841804 01/01/1985       119 Citations
  • Damaging effects of oxygen radicals on resealed erythrocyte ghosts. (Girotti AW, Thomas JP) J Biol Chem 1984 Feb 10;259(3):1744-52 PMID: 6546380 02/10/1984       136 Citations
  • Superoxide and hydrogen peroxide-dependent lipid peroxidation in intact and triton-dispersed erythrocyte membranes. (Girotti AW, Thomas JP) Biochem Biophys Res Commun 1984 Jan 30;118(2):474-80 PMID: 6322749 01/30/1984       68 Citations
  • Mechanisms of photosensitization. (Girotti AW) Photochem Photobiol 1983 Dec;38(6):745-51 PMID: 6366837 12/01/1983       94 Citations
  • Photodynamic action of protoporphyrin on resealed erythrocyte membranes: mechanisms of release of trapped markers. (Girotti AW, Deziel MR) Adv Exp Med Biol 1983;160:213-25 PMID: 6837353 01/01/1983       53 Citations
  • Lysis of resealed erythrocyte ghosts by photoactivated tetrapyrroles: estimation of photolesion dimensions. (Deziel MR, Girotti AW) Int J Biochem 1982;14(4):263-6 PMID: 7067905 01/01/1982       15 Citations
  • Photosensitized cross-linking of erythrocyte membrane proteins. Evidence against participation of amino groups in the reaction. (Girotti AW) Biochim Biophys Acta 1980 Oct 16;602(1):45-56 PMID: 7417451 10/16/1980       30 Citations
  • Photodynamic action of bilirubin on liposomes and erythrocyte membranes. (Deziel MR, Girotti AW) J Biol Chem 1980 Sep 10;255(17):8192-8 PMID: 7410359 09/10/1980       45 Citations
  • Bilirubin-photosensitized lysis of resealed erythrocyte membranes. (Deziel MR, Girotti AW) Photochem Photobiol 1980 Jun;31(6):593-6 PMID: 7394001 06/01/1980       16 Citations
  • Protoporphyrin-sensitized photodamage in isolated membranes of human erythrocytes. (Girotti AW) Biochemistry 1979 Oct 02;18(20):4403-11 PMID: 158380 10/02/1979       60 Citations
  • Methylene blue-sensitized photooxidation of hemoglobin: evidence for cross-link formation. (Girotti AW, Lyman S, Deziel MR) Photochem Photobiol 1979 Jun;29(6):1119-25 PMID: 504349 06/01/1979       16 Citations
  • Bilirubin-photosensitized cross-linking of polypeptides in the isolated membrane of the human erythrocyte. (Girotti AW) J Biol Chem 1978 Oct 25;253(20):7186-93 PMID: 701243 10/25/1978       29 Citations
  • Purification of calciferol-binding proteins from kidney: physicochemical and immunological properties. (Ghazarian JG, Hsu PY, Girotti AW, Winkelhake JL) J Lipid Res 1978 Jul;19(5):601-12 PMID: 670835 07/01/1978       8 Citations
  • Bilirubin-sensitized photoinactivation of enzymes in the isolated membrane of the human erythrocyte. (Girotti AW) Photochem Photobiol 1976 Dec;24(6):525-32 PMID: 1019244 12/01/1976       19 Citations
  • Photodynamic action of protoporphyrin IX on human erythrocytes: cross-linking of membrane proteins. (Girotti AW) Biochem Biophys Res Commun 1976 Oct 18;72(4):1367-74 PMID: 999678 10/18/1976       79 Citations
  • Glyceraldehyde-3-phosphate dehydrogenase in the isolated human erthrocyte membrane: selective displacement by bilirubin. (Girotti AW) Arch Biochem Biophys 1976 Mar;173(1):210-8 PMID: 176946 03/01/1976       5 Citations
  • Interaction of inhibitors with muscle phosphofructokinase. (Colombo G, Tate PW, Girotti AW, Kemp RG) J Biol Chem 1975 Dec 25;250(24):9404-12 PMID: 127795 12/25/1975       45 Citations
  • Photodynamic action of bilirubin on human erythrocyte membranes. Modification of polypeptide constituents. (Girotti AW) Biochemistry 1975 Jul 29;14(15):3377-83 PMID: 1148207 07/29/1975       49 Citations
  • The protoporphyrin-apoperoxidase complex. Photooxidation studies. (Mauk MR, Girotti AW) Biochemistry 1974 Apr 09;13(8):1757-63 PMID: 4831362 04/09/1974       40 Citations
  • Photooxidation of the protoporphyrin-apomyoglobin complex. (Mauk MR, Girotti AW) Biochemistry 1973 Aug 14;12(17):3187-93 PMID: 4738934 08/14/1973       20 Citations
  • The interaction of ribonuclease with metal ions. IV. Role of the alpha-amino group in cupric ion binding. (Girotti AW, Breslow E) J Biol Chem 1970 Jun;245(12):3066-74 PMID: 5464658 06/01/1970       7 Citations
  • The interaction of ribonuclease with metal ions. 3. Gel filtration studies on the relationship between cupric ion and cytidylic acid binding. (Breslow E, Girotti AW) J Biol Chem 1970 Apr 10;245(7):1527-36 PMID: 5461954 04/10/1970       14 Citations
  • The interaction of ribonuclease with metal ions. II. Gel filtration studies of cupric ion-ribonuclease interactions. (Girotti AW, Breslow E) J Biol Chem 1968 Jan 10;243(1):216-8 PMID: 5635943 01/10/1968       11 Citations
  • Properties of protoporphyrin-apomyoglobin complexes and related compounds. (Breslow E, Koehler R, Girotti AW) J Biol Chem 1967 Sep 25;242(18):4149-56 PMID: 6054042 09/25/1967       28 Citations
  • The interaction of ribonuclease with metal ions. I. Studies of cupric and zinc ions and the effect of cytidylic acid. (Breslow E, Girotti AW) J Biol Chem 1966 Dec 10;241(23):5651-60 PMID: 5928203 12/10/1966       20 Citations
  • Last update: 01/02/2019
    jenkins-FCD Prod-299 9ef562391eceb2b8f95265c767fbba1ce5a52fd6