Medical College of Wisconsin
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Albert W. Girotti PhD

Albert W. Girotti PhD

Professor

Institution: Medical College of Wisconsin
Department: Biochemistry


Publications

  • Deleterious cholesterol hydroperoxide trafficking in steroidogenic acute regulatory (StAR) protein-expressing MA-10 Leydig cells: implications for oxidative stress-impaired steroidogenesis. (Korytowski W, Pilat A, Schmitt JC, Girotti AW) J Biol Chem 2013 Apr 19;288(16):11509-19 PMID 23467407
  • Cytoprotective signaling associated with nitric oxide upregulation in tumor cells subjected to photodynamic therapy-like oxidative stress. (Bhowmick R, Girotti AW) Free Radic Biol Med 2013 Apr;57:39-48 PMID 23261943
  • Relationship between oxidizable fatty acid content and level of antioxidant glutathione peroxidases in marine fish. (Grim JM, Hyndman KA, Kriska T, Girotti AW, Crockett EL) J Exp Biol 2011 Nov 15;214(Pt 22):3751-9 PMID 22031739
  • Permeabilization of the mitochondrial outer membrane by Bax/truncated Bid (tBid) proteins as sensitized by cardiolipin hydroperoxide translocation: mechanistic implications for the intrinsic pathway of oxidative apoptosis. (Korytowski W, Basova LV, Pilat A, Kernstock RM, Girotti AW) J Biol Chem 2011 Jul 29;286(30):26334-43 PMID 21642428
  • Photodynamic therapy of cancer: an update. (Agostinis P, Berg K, Cengel KA, Foster TH, Girotti AW, Gollnick SO, Hahn SM, Hamblin MR, Juzeniene A, Kessel D, Korbelik M, Moan J, Mroz P, Nowis D, Piette J, Wilson BC, Golab J) CA Cancer J Clin 2011 Jul-Aug;61(4):250-81 PMID 21617154
  • Rapid upregulation of cytoprotective nitric oxide in breast tumor cells subjected to a photodynamic therapy-like oxidative challenge. (Bhowmick R, Girotti AW) Photochem Photobiol 2011 Mar-Apr;87(2):378-86 PMID 21143607
  • Sterol carrier protein-2 (SCP-2) involvement in cholesterol hydroperoxide cytotoxicity as revealed by SCP-2 inhibitor effects. (Kriska T, Pilat A, Schmitt JC, Girotti AW) J Lipid Res 2010 Nov;51(11):3174-84 PMID 20656919
  • Introduction to the symposium-in-print: photobiology of the skin and eye in memory of Colin F. Chignell. (Roberts JE, Girotti AW, Buettner GR, He YY) Photochem Photobiol 2010 Jul-Aug;86(4):740-1 PMID 20653881
  • Surprising inability of singlet oxygen-generated 6-hydroperoxycholesterol to induce damaging free radical lipid peroxidation in cell membranes. (Korytowski W, Schmitt JC, Girotti AW) Photochem Photobiol 2010 Jul-Aug;86(4):747-51 PMID 20408976
  • Apoptosis-accommodating effect of nitric oxide in photodynamically stressed tumor cells. (Niziolek-Kierecka M, Pilat A, Korytowski W, Girotti AW) Photochem Photobiol 2010 May-Jun;86(3):681-6 PMID 20331521
  • Cytoprotective induction of nitric oxide synthase in a cellular model of 5-aminolevulinic acid-based photodynamic therapy. (Bhowmick R, Girotti AW) Free Radic Biol Med 2010 May 15;48(10):1296-301 PMID 20138143
  • StarD4-mediated translocation of 7-hydroperoxycholesterol to isolated mitochondria: deleterious effects and implications for steroidogenesis under oxidative stress conditions. (Korytowski W, Rodriguez-Agudo D, Pilat A, Girotti AW) Biochem Biophys Res Commun 2010 Jan 29;392(1):58-62 PMID 20059974
  • Signaling events in apoptotic photokilling of 5-aminolevulinic acid-treated tumor cells: inhibitory effects of nitric oxide. (Bhowmick R, Girotti AW) Free Radic Biol Med 2009 Sep 15;47(6):731-40 PMID 19524035
  • New strategies for the isolation and activity determination of naturally occurring type-4 glutathione peroxidase. (Kernstock RM, Girotti AW) Protein Expr Purif 2008 Dec;62(2):216-22 PMID 18723092
  • Novel enrichment of tumor cell transfectants expressing high levels of type 4 glutathione peroxidase using 7alpha-hydroperoxycholesterol as a selection agent. (Kriska T, Levchenko VV, Chu FF, Esworthy RS, Girotti AW) Free Radic Biol Med 2008 Sep 1;45(5):700-7 PMID 18554519
  • Translocation as a means of disseminating lipid hydroperoxide-induced oxidative damage and effector action. (Girotti AW) Free Radic Biol Med 2008 Mar 15;44(6):956-68 PMID 18206663
  • Lipid transfer protein binding of unmodified natural lipids as assessed by surface plasmon resonance methodology. (Kernstock RM, Girotti AW) Anal Biochem 2007 Jun 1;365(1):111-21 PMID 17376396
  • Phospholipase action of platelet-activating factor acetylhydrolase, but not paraoxonase-1, on long fatty acyl chain phospholipid hydroperoxides. (Kriska T, Marathe GK, Schmidt JC, McIntyre TM, Girotti AW) J Biol Chem 2007 Jan 5;282(1):100-8 PMID 17090529
  • Intracellular dissemination of peroxidative stress. Internalization, transport, and lethal targeting of a cholesterol hydroperoxide species by sterol carrier protein-2-overexpressing hepatoma cells. (Kriska T, Levchenko VV, Korytowski W, Atshaves BP, Schroeder F, Girotti AW) J Biol Chem 2006 Aug 18;281(33):23643-51 PMID 16772292
  • Nitric oxide-induced resistance to lethal photooxidative damage in a breast tumor cell line. (Niziolek M, Korytowski W, Girotti AW) Free Radic Biol Med 2006 Apr 15;40(8):1323-31 PMID 16631522
  • Separation and quantitation of phospholipid hydroperoxide families using high-performance liquid chromatography with mercury cathode electrochemical detection. (Korytowski W, Niziolek M, Girotti AW) Anal Biochem 2005 Aug 1;343(1):136-42 PMID 15979556
  • A thin layer chromatographic method for determining the enzymatic activity of peroxidases catalyzing the two-electron reduction of lipid hydroperoxides. (Kriska T, Girotti AW) J Chromatogr B Analyt Technol Biomed Life Sci 2005 Nov 15;827(1):58-64 PMID 15899595
  • Merocyanine 540-sensitized photokilling of leukemia cells: role of post-irradiation chain peroxidation of plasma membrane lipids as revealed by nitric oxide protection. (Zareba M, Niziolek M, Korytowski W, Girotti AW) Biochim Biophys Acta 2005 Feb 11;1722(1):51-9 PMID 15716134
  • Self-sensitized photodegradation of membrane-bound protoporphyrin mediated by chain lipid peroxidation: inhibition by nitric oxide with sustained singlet oxygen damage. (Niziolek M, Korytowski W, Girotti AW) Photochem Photobiol 2005 Mar-Apr;81(2):299-305 PMID 15647001
  • Role of mitochondrial cardiolipin peroxidation in apoptotic photokilling of 5-aminolevulinate-treated tumor cells. (Kriska T, Korytowski W, Girotti AW) Arch Biochem Biophys 2005 Jan 15;433(2):435-46 PMID 15581600
  • Sterol carrier protein-2-facilitated intermembrane transfer of cholesterol- and phospholipid-derived hydroperoxides. (Vila A, Levchenko VV, Korytowski W, Girotti AW) Biochemistry 2004 Oct 5;43(39):12592-605 PMID 15449949
  • Separation and quantitation of peroxidized phospholipids using high-performance thin-layer chromatography with tetramethyl-p-phenylenediamine detection. (Kriska T, Girotti AW) Anal Biochem 2004 Apr 1;327(1):97-106 PMID 15033516
  • Role of lipid hydroperoxides in photo-oxidative stress signaling. (Girotti AW, Kriska T) Antioxid Redox Signal 2004 Apr;6(2):301-10 PMID 15025931
  • Chain-breaking antioxidant and cytoprotective action of nitric oxide on photodynamically stressed tumor cells. (Niziolek M, Korytowski W, Girotti AW) Photochem Photobiol 2003 Sep;78(3):262-70 PMID 14556313
  • Nitric oxide inhibition of free radical-mediated lipid peroxidation in photodynamically treated membranes and cells. (Niziolek M, Korytowski W, Girotti AW) Free Radic Biol Med 2003 Apr 15;34(8):997-1005 PMID 12684084
  • Spontaneous transfer of phospholipid and cholesterol hydroperoxides between cell membranes and low-density lipoprotein: assessment of reaction kinetics and prooxidant effects. (Vila A, Korytowski W, Girotti AW) Biochemistry 2002 Nov 19;41(46):13705-16 PMID 12427033
  • Hyperresistance to photosensitized lipid peroxidation and apoptotic killing in 5-aminolevulinate-treated tumor cells overexpressing mitochondrial GPX4. (Kriska T, Korytowski W, Girotti AW) Free Radic Biol Med 2002 Nov 15;33(10):1389-402 PMID 12419471
  • Spontaneous intermembrane transfer of various cholesterol-derived hydroperoxide species: kinetic studies with model membranes and cells. (Vila A, Korytowski W, Girotti AW) Biochemistry 2001 Dec 4;40(48):14715-26 PMID 11724586
  • Photosensitized oxidation of membrane lipids: reaction pathways, cytotoxic effects, and cytoprotective mechanisms. (Girotti AW) J Photochem Photobiol B 2001 Oct;63(1-3):103-13 PMID 11684457
  • Hyperresistance to cholesterol hydroperoxide-induced peroxidative injury and apoptotic death in a tumor cell line that overexpresses glutathione peroxidase isotype-4. (Hurst R, Korytowski W, Kriska T, Esworthy RS, Chu FF, Girotti AW) Free Radic Biol Med 2001 Nov 1;31(9):1051-65 PMID 11677038
  • Inhibition of free radical-mediated cholesterol peroxidation by diazeniumdiolate-derived nitric oxide: effect of release rate on mechanism of action in a membrane system. (Korytowski W, Zareba M, Girotti AW) Chem Res Toxicol 2000 Dec;13(12):1265-74 PMID 11123968
  • Cholesterol as a singlet oxygen detector in biological systems. (Girotti AW, Korytowski W) Methods Enzymol 2000;319:85-100 PMID 10907502
  • Dissemination of peroxidative stress via intermembrane transfer of lipid hydroperoxides: model studies with cholesterol hydroperoxides. (Vila A, Korytowski W, Girotti AW) Arch Biochem Biophys 2000 Aug 1;380(1):208-18 PMID 10900151
  • Nitric oxide inhibition of free radical-mediated cholesterol peroxidation in liposomal membranes. (Korytowski W, Zareba M, Girotti AW) Biochemistry 2000 Jun 13;39(23):6918-28 PMID 10841773
  • Singlet oxygen adducts of cholesterol: photogeneration and reductive turnover in membrane systems. (Korytowski W, Girotti AW) Photochem Photobiol 1999 Oct;70(4):484-9 PMID 10546545
  • Low-density lipoprotein susceptibility to oxidation and cytotoxicity to endothelium in sickle cell anemia. (Belcher JD, Marker PH, Geiger P, Girotti AW, Steinberg MH, Hebbel RP, Vercellotti GM) J Lab Clin Med 1999 Jun;133(6):605-12 PMID 10360636
  • Radiolabeled cholesterol as a reporter for assessing one-electron turnover of lipid hydroperoxides. (Korytowski W, Wrona M, Girotti AW) Anal Biochem 1999 May 15;270(1):123-32 PMID 10328773
  • Protoporphyrin IX-sensitized photoinactivation of 5-aminolevulinate-treated leukemia cells: effects of exogenous iron. (Lin F, Geiger PG, Korytowski W, Girotti AW) Photochem Photobiol 1999 Mar;69(3):375-81 PMID 10089831
  • Lipid hydroperoxide analysis by high-performance liquid chromatography with mercury cathode electrochemical detection. (Korytowski W, Geiger PG, Girotti AW) Methods Enzymol 1999;300:23-33 PMID 9919505
  • Delayed hyperresistance of endothelial cells to photodynamic inactivation after contact with hemin. (Lin F, Bertling CJ, Geiger PG, Girotti AW) Photochem Photobiol 1998 Aug;68(2):211-7 PMID 9723213
  • Lipid hydroperoxide generation, turnover, and effector action in biological systems. (Girotti AW) J Lipid Res 1998 Aug;39(8):1529-42 PMID 9717713
  • Hemin-enhanced resistance of human leukemia cells to oxidative killing: antisense determination of ferritin involvement. (Lin F, Girotti AW) Arch Biochem Biophys 1998 Apr 1;352(1):51-8 PMID 9521813
  • Elevated ferritin production, iron containment, and oxidant resistance in hemin-treated leukemia cells. (Lin F, Girotti AW) Arch Biochem Biophys 1997 Oct 1;346(1):131-41 PMID 9328293
  • Lipid peroxidation in photodynamically stressed mammalian cells: use of cholesterol hydroperoxides as mechanistic reporters. (Geiger PG, Korytowski W, Lin F, Girotti AW) Free Radic Biol Med 1997;23(1):57-68 PMID 9165297
  • Hyperresistance of leukemia cells to photodynamic inactivation after long-term exposure to hemin. (Lin F, Girotti AW) Cancer Res 1996 Oct 15;56(20):4636-43 PMID 8840977
  • Enzymatic reducibility in relation to cytotoxicity for various cholesterol hydroperoxides. (Korytowski W, Geiger PG, Girotti AW) Biochemistry 1996 Jul 2;35(26):8670-9 PMID 8679629
  • Role of hydrogen peroxide in the cytotoxic effects of UVA/B radiation on mammalian cells. (Bertling CJ, Lin F, Girotti AW) Photochem Photobiol 1996 Jul;64(1):137-42 PMID 8787007
  • Photodynamically generated 3-beta-hydroxy-5 alpha-cholest-6-ene-5- hydroperoxide: toxic reactivity in membranes and susceptibility to enzymatic detoxification. (Geiger PG, Korytowski W, Girotti AW) Photochem Photobiol 1995 Sep;62(3):580-7 PMID 8570716
  • Stimulatory and inhibitory effects of iron on photodynamic inactivation of leukemia cells. (Lin F, Girotti AW) Photochem Photobiol 1995 Sep;62(3):528-34 PMID 8570708
  • High-performance liquid chromatography with mercury cathode electrochemical detection: application to lipid hydroperoxide analysis. (Korytowski W, Geiger PG, Girotti AW) J Chromatogr B Biomed Appl 1995 Aug 18;670(2):189-97 PMID 8548009
  • Selenoperoxidase-dependent glutathione cycle activity in peroxide-challenged leukemia cells. (Korytowski W, Bachowski GJ, Geiger PG, Lin F, Zhao G, Girotti AW) Biochim Biophys Acta 1995 May 29;1267(1):31-40 PMID 7779866
  • Amplification and hyperexpression of the catalase gene in selenoperoxidase-deficient leukemia cells. (Lin F, Jackson VE, Girotti AW) Arch Biochem Biophys 1995 Feb 20;317(1):7-18 PMID 7872806
  • Involvement of preexisting lipid hydroperoxides in Cu(2+)-stimulated oxidation of low-density lipoprotein. (Thomas JP, Kalyanaraman B, Girotti AW) Arch Biochem Biophys 1994 Dec;315(2):244-54 PMID 7986064
  • Characterization of lipid hydroperoxides generated by photodynamic treatment of leukemia cells. (Bachowski GJ, Korytowski W, Girotti AW) Lipids 1994 Jul;29(7):449-59 PMID 7968265
  • Bleaching of membrane-bound merocyanine 540 in conjunction with free radical-mediated lipid peroxidation. (Pintar TJ, Lin F, Girotti AW) Free Radic Biol Med 1994 May;16(5):603-12 PMID 8026803
  • Cytoprotection against merocyanine 540-sensitized photoinactivation of the Na+,K(+)-adenosine triphosphatase in leukemia cells: glutathione and selenoperoxidase involvement. (Lin F, Girotti AW) Photochem Photobiol 1994 Mar;59(3):320-7 PMID 8016211
  • Reactivity of plasma glutathione peroxidase with hydroperoxide substrates and glutathione. (Esworthy RS, Chu FF, Geiger P, Girotti AW, Doroshow JH) Arch Biochem Biophys 1993 Nov 15;307(1):29-34 PMID 8239661
  • Hyperexpression of catalase in selenium-deprived murine L1210 cells. (Lin F, Thomas JP, Girotti AW) Arch Biochem Biophys 1993 Aug 15;305(1):176-85 PMID 8342949
  • Analysis of cholesterol and phospholipid hydroperoxides by high-performance liquid chromatography with mercury drop electrochemical detection. (Korytowski W, Bachowski GJ, Girotti AW) Anal Biochem 1993 Aug 15;213(1):111-9 PMID 8238862
  • Lethal damage to endothelial cells by oxidized low density lipoprotein: role of selenoperoxidases in cytoprotection against lipid hydroperoxide- and iron-mediated reactions. (Thomas JP, Geiger PG, Girotti AW) J Lipid Res 1993 Mar;34(3):479-90 PMID 8468531
  • Selenoperoxidase-mediated cytoprotection against the damaging effects of tert-butyl hydroperoxide on leukemia cells. (Geiger PG, Lin F, Girotti AW) Free Radic Biol Med 1993 Mar;14(3):251-66 PMID 8458583
  • Photodynamic action of merocyanine 540 on leukemia cells: iron-stimulated lipid peroxidation and cell killing. (Lin F, Girotti AW) Arch Biochem Biophys 1993 Feb 1;300(2):714-23 PMID 8434951
  • Selenoperoxidase-mediated cytoprotection against merocyanine 540-sensitized photoperoxidation and photokilling of leukemia cells. (Lin F, Geiger PG, Girotti AW) Cancer Res 1992 Oct 1;52(19):5282-90 PMID 1394132
  • Photoperoxidation of cholesterol in homogeneous solution, isolated membranes, and cells: comparison of the 5 alpha- and 6 beta-hydroperoxides as indicators of singlet oxygen intermediacy. (Korytowski W, Bachowski GJ, Girotti AW) Photochem Photobiol 1992 Jul;56(1):1-8 PMID 1508976
  • Photosensitized oxidation of cholesterol in biological systems: reaction pathways, cytotoxic effects and defense mechanisms. (Girotti AW) J Photochem Photobiol B 1992 Apr 30;13(2):105-18 PMID 1506985
  • Photodynamic action of merocyanine 540 on erythrocyte membranes: structural perturbation of lipid and protein constituents. (Feix JB, Bachowski GJ, Girotti AW) Biochim Biophys Acta 1991 Sep 2;1075(1):28-35 PMID 1654108
  • Chromatographic separation and electrochemical determination of cholesterol hydroperoxides generated by photodynamic action. (Korytowski W, Bachowski GJ, Girotti AW) Anal Biochem 1991 Aug 15;197(1):149-56 PMID 1952058
  • Lethal damage to murine L1210 cells by exogenous lipid hydroperoxides: protective role of glutathione-dependent selenoperoxidases. (Geiger PG, Thomas JP, Girotti AW) Arch Biochem Biophys 1991 Aug 1;288(2):671-80 PMID 1898056
  • Phthalocyanine-sensitized lipid peroxidation in cell membranes: use of cholesterol and azide as probes of primary photochemistry. (Bachowski GJ, Ben-Hur E, Girotti AW) J Photochem Photobiol B 1991 Jun;9(3-4):307-21 PMID 1919874
  • Photodynamic action of merocyanine 540 in artificial bilayers and natural membranes: action spectra and quantum yields. (Singh RJ, Feix JB, Pintar TJ, Girotti AW, Kalyanaraman B) Photochem Photobiol 1991 Apr;53(4):493-500 PMID 1857744
  • Photosensitized lipid peroxidation and enzyme inactivation by membrane-bound merocyanine 540: reaction mechanisms in the absence and presence of ascorbate. (Bachowski GJ, Pintar TJ, Girotti AW) Photochem Photobiol 1991 Apr;53(4):481-91 PMID 1857743
  • Reactivity of phospholipid hydroperoxide glutathione peroxidase with membrane and lipoprotein lipid hydroperoxides. (Maiorino M, Thomas JP, Girotti AW, Ursini F) Free Radic Res Commun 1991;12-13 Pt 1:131-5 PMID 2071029
  • Enzymatic reduction of phospholipid and cholesterol hydroperoxides in artificial bilayers and lipoproteins. (Thomas JP, Geiger PG, Maiorino M, Ursini F, Girotti AW) Biochim Biophys Acta 1990 Aug 6;1045(3):252-60 PMID 2386798
  • Photodynamic lipid peroxidation in biological systems. (Girotti AW) Photochem Photobiol 1990 Apr;51(4):497-509 PMID 2188273
  • Protective action of phospholipid hydroperoxide glutathione peroxidase against membrane-damaging lipid peroxidation. In situ reduction of phospholipid and cholesterol hydroperoxides. (Thomas JP, Maiorino M, Ursini F, Girotti AW) J Biol Chem 1990 Jan 5;265(1):454-61 PMID 2294113
  • Role of lipid peroxidation in hematoporphyrin derivative-sensitized photokilling of tumor cells: protective effects of glutathione peroxidase. (Thomas JP, Girotti AW) Cancer Res 1989 Apr 1;49(7):1682-6 PMID 2522345
  • Glucose administration augments in vivo uptake and phototoxicity of the tumor-localizing fraction of hematoporphyrin derivative. (Thomas JP, Girotti AW) Photochem Photobiol 1989 Mar;49(3):241-7 PMID 2525259
  • Reactivity of photochemically-generated lipid hydroperoxides in cell membranes with glutathione peroxidase. (Thomas JP, Girotti AW) Photochem Photobiol 1989 Feb;49(2):153-6 PMID 2523541
  • Photooxidation of cell membranes in the presence of hematoporphyrin derivative: reactivity of phospholipid and cholesterol hydroperoxides with glutathione peroxidase. (Thomas JP, Girotti AW) Biochim Biophys Acta 1988 Oct 14;962(3):297-307 PMID 2971397
  • Ascorbate-enhanced lipid peroxidation in photooxidized cell membranes: cholesterol product analysis as a probe of reaction mechanism. (Bachowski GJ, Thomas JP, Girotti AW) Lipids 1988 Jun;23(6):580-6 PMID 3172988
  • Porphyrin-sensitized photoreactions in the presence of ascorbate: oxidation of cell membrane lipids and hydroxyl radical traps. (Bachowski GJ, Morehouse KM, Girotti AW) Photochem Photobiol 1988 May;47(5):635-45 PMID 2841702
  • Light-stimulated formation of hydrogen peroxide and hydroxyl radical in the presence of uroporphyrin and ascorbate. (Bachowski GJ, Girotti AW) Free Radic Biol Med 1988;5(1):3-6 PMID 2855416
  • Lipid peroxidation in erythrocyte membranes: cholesterol product analysis in photosensitized and xanthine oxidase-catalyzed reactions. (Girotti AW, Bachowski GJ, Jordan JE) Lipids 1987 Jun;22(6):401-8 PMID 3112484
  • Singlet oxygen intermediacy in the photodynamic action of membrane-bound hematoporphyrin derivative. (Thomas JP, Hall RD, Girotti AW) Cancer Lett 1987 Jun;35(3):295-302 PMID 2954632
  • Photodynamic action of merocyanine 540 on artificial and natural cell membranes: involvement of singlet molecular oxygen. (Kalyanaraman B, Feix JB, Sieber F, Thomas JP, Girotti AW) Proc Natl Acad Sci U S A 1987 May;84(9):2999-3003 PMID 3033673
  • Inhibition of cell membrane lipid peroxidation by cadmium- and zinc-metallothioneins. (Thomas JP, Bachowski GJ, Girotti AW) Biochim Biophys Acta 1986 Dec 10;884(3):448-61 PMID 3778934
  • Xanthine oxidase-catalyzed crosslinking of cell membrane proteins. (Girotti AW, Thomas JP, Jordan JE) Arch Biochem Biophys 1986 Dec;251(2):639-53 PMID 3800391
  • Photohemolysis of human erythrocytes labeled in band 3 with eosin-isothiocyanate. (Pooler JP, Girotti AW) Photochem Photobiol 1986 Oct;44(4):495-9 PMID 2431425
  • Prooxidant and antioxidant effects of ascorbate on photosensitized peroxidation of lipids in erythrocyte membranes. (Girotti AW, Thomas JP, Jordan JE) Photochem Photobiol 1985 Mar;41(3):267-76 PMID 4011692
  • Mechanisms of lipid peroxidation. (Girotti AW) J Free Radic Biol Med 1985;1(2):87-95 PMID 3915303
  • Phototoxic effects of hematoporphyrin derivative and its chromatographic fractions on hormone-producing human malignant trophoblast cells in vitro. (Girotti AW, Hussa RO) Adv Exp Med Biol 1985;193:129-45 PMID 2937259
  • Lipid photooxidation in erythrocyte ghosts: sensitization of the membranes toward ascorbate- and superoxide-induced peroxidation and lysis. (Girotti AW, Thomas JP, Jordan JE) Arch Biochem Biophys 1985 Jan;236(1):238-51 PMID 2981506
  • Inhibitory effect of zinc(II) on free radical lipid peroxidation in erythrocyte membranes. (Girotti AW, Thomas JP, Jordan JE) J Free Radic Biol Med 1985;1(5-6):395-401 PMID 3841804
  • Damaging effects of oxygen radicals on resealed erythrocyte ghosts. (Girotti AW, Thomas JP) J Biol Chem 1984 Feb 10;259(3):1744-52 PMID 6546380
  • Superoxide and hydrogen peroxide-dependent lipid peroxidation in intact and triton-dispersed erythrocyte membranes. (Girotti AW, Thomas JP) Biochem Biophys Res Commun 1984 Jan 30;118(2):474-80 PMID 6322749
  • Mechanisms of photosensitization. (Girotti AW) Photochem Photobiol 1983 Dec;38(6):745-51 PMID 6366837
  • Photodynamic action of protoporphyrin on resealed erythrocyte membranes: mechanisms of release of trapped markers. (Girotti AW, Deziel MR) Adv Exp Med Biol 1983;160:213-25 PMID 6837353
  • Lysis of resealed erythrocyte ghosts by photoactivated tetrapyrroles: estimation of photolesion dimensions. (Deziel MR, Girotti AW) Int J Biochem 1982;14(4):263-6 PMID 7067905
  • Photosensitized cross-linking of erythrocyte membrane proteins. Evidence against participation of amino groups in the reaction. (Girotti AW) Biochim Biophys Acta 1980 Oct 16;602(1):45-56 PMID 7417451
  • Photodynamic action of bilirubin on liposomes and erythrocyte membranes. (Deziel MR, Girotti AW) J Biol Chem 1980 Sep 10;255(17):8192-8 PMID 7410359
  • Bilirubin-photosensitized lysis of resealed erythrocyte membranes. (Deziel MR, Girotti AW) Photochem Photobiol 1980 Jun;31(6):593-6 PMID 7394001
  • Protoporphyrin-sensitized photodamage in isolated membranes of human erythrocytes. (Girotti AW) Biochemistry 1979 Oct 2;18(20):4403-11 PMID 158380
  • Methylene blue-sensitized photooxidation of hemoglobin: evidence for cross-link formation. (Girotti AW, Lyman S, Deziel MR) Photochem Photobiol 1979 Jun;29(6):1119-25 PMID 504349
  • Bilirubin-photosensitized cross-linking of polypeptides in the isolated membrane of the human erythrocyte. (Girotti AW) J Biol Chem 1978 Oct 25;253(20):7186-93 PMID 701243
  • Purification of calciferol-binding proteins from kidney: physicochemical and immunological properties. (Ghazarian JG, Hsu PY, Girotti AW, Winkelhake JL) J Lipid Res 1978 Jul;19(5):601-12 PMID 670835
  • Bilirubin-sensitized photoinactivation of enzymes in the isolated membrane of the human erythrocyte. (Girotti AW) Photochem Photobiol 1976 Dec;24(6):525-32 PMID 1019244
  • Photodynamic action of protoporphyrin IX on human erythrocytes: cross-linking of membrane proteins. (Girotti AW) Biochem Biophys Res Commun 1976 Oct 18;72(4):1367-74 PMID 999678
  • Glyceraldehyde-3-phosphate dehydrogenase in the isolated human erthrocyte membrane: selective displacement by bilirubin. (Girotti AW) Arch Biochem Biophys 1976 Mar;173(1):210-8 PMID 176946
  • Interaction of inhibitors with muscle phosphofructokinase. (Colombo G, Tate PW, Girotti AW, Kemp RG) J Biol Chem 1975 Dec 25;250(24):9404-12 PMID 127795
  • Photodynamic action of bilirubin on human erythrocyte membranes. Modification of polypeptide constituents. (Girotti AW) Biochemistry 1975 Jul 29;14(15):3377-83 PMID 1148207
  • The protoporphyrin-apoperoxidase complex. Photooxidation studies. (Mauk MR, Girotti AW) Biochemistry 1974 Apr 9;13(8):1757-63 PMID 4831362
  • Photooxidation of the protoporphyrin-apomyoglobin complex. (Mauk MR, Girotti AW) Biochemistry 1973 Aug 14;12(17):3187-93 PMID 4738934
  • The interaction of ribonuclease with metal ions. IV. Role of the alpha-amino group in cupric ion binding. (Girotti AW, Breslow E) J Biol Chem 1970 Jun;245(12):3066-74 PMID 5464658
  • The interaction of ribonuclease with metal ions. 3. Gel filtration studies on the relationship between cupric ion and cytidylic acid binding. (Breslow E, Girotti AW) J Biol Chem 1970 Apr 10;245(7):1527-36 PMID 5461954
  • The interaction of ribonuclease with metal ions. II. Gel filtration studies of cupric ion-ribonuclease interactions. (Girotti AW, Breslow E) J Biol Chem 1968 Jan 10;243(1):216-8 PMID 5635943
  • Properties of protoporphyrin-apomyoglobin complexes and related compounds. (Breslow E, Koehler R, Girotti AW) J Biol Chem 1967 Sep 25;242(18):4149-56 PMID 6054042
  • The interaction of ribonuclease with metal ions. I. Studies of cupric and zinc ions and the effect of cytidylic acid. (Breslow E, Girotti AW) J Biol Chem 1966 Dec 10;241(23):5651-60 PMID 5928203
  • Grants and Awards

  • Upregulation of Cytoprotective Nitric Oxide in Photodynamic Therapy For Breast Cancer (#9305349 06/01/2011 - 05/31/2014) Sponsor: Cancer Center
  • Role of Oxidized Cardiolipin Translocation in Oxidative Stress Induced Apoptosis (#9204579 05/01/2007 - 04/30/2012) Sponsor: NIH Heart Lung and Blood Institute
  • Iron, NO, and Lipid Peroxides in Photodynamic Therapy (#9207048 08/01/2011 - 05/31/2016) Sponsor: NIH Cancer Institute
  • Lipid Hydroperoxide Cytotoxicity and Detoxification (#9202984 08/08/2003 - 05/31/2009) Sponsor: NIH Cancer Institute
  • Iron, NO & Lipid Peroxides in Photodynamic Therapy (#9201726 07/01/2000 - 03/31/2006) Sponsor: NIH Cancer Institute
  • Iron, NO, and Lipid Peroxides in Photodynamic Therapy (#9204075 04/01/2006 - 07/31/2011) Sponsor: NIH Cancer Institute