Medical College of Wisconsin
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Alexander C. Mackinnon Jr MD, PhD

Alexander C. Mackinnon Jr MD, PhD

Associate Professor

Institution: Medical College of Wisconsin
Department: Pathology
Division: Administration

Member of the Cancer Center


  • Depletion of M2-like tumor-associated macrophages delays cutaneous T-cell lymphoma development in vivo. (Wu X, Schulte BC, Zhou Y, Haribhai D, Mackinnon AC, Plaza JA, Williams CB, Hwang ST) J Invest Dermatol 2014 Nov;134(11):2814-22 PMID: 24780929
  • Antral atrophy, intestinal metaplasia, and preneoplastic markers in Mexican children with Helicobacter pylori-positive and Helicobacter pylori-negative gastritis. (Villarreal-Calderon R, Luévano-González A, Aragón-Flores M, Zhu H, Yuan Y, Xiang Q, Yan B, Stoll KA, Cross JV, Iczkowski KA, Mackinnon AC Jr) Ann Diagn Pathol 2014 Jun;18(3):129-35 PMID: 24656654
  • CXCL12 chemokine expression suppresses human pancreatic cancer growth and metastasis. (Roy I, Zimmerman NP, Mackinnon AC, Tsai S, Evans DB, Dwinell MB) PLoS One 2014;9(3):e90400 PMID: 24594697 PMCID: PMC3942415
  • Dickkopf-1, the Wnt antagonist, is induced by acidic pH and mediates epithelial cellular senescence in human reflux esophagitis. (Lyros O, Rafiee P, Nie L, Medda R, Jovanovic N, Schmidt J, Mackinnon A, Venu N, Shaker R) Am J Physiol Gastrointest Liver Physiol 2014 Apr 1;306(7):G557-74 PMID: 24481601 PMCID: PMC3962590
  • Cribriform adenocarcinoma of the lung: clinicopathologic, immunohistochemical, and molecular analysis of 15 cases of a distinctive morphologic subtype of lung adenocarcinoma. (Mackinnon AC Jr, Luevano A, de Araujo LC, Rao N, Le M, Suster S) Mod Pathol 2014 Aug;27(8):1063-72 PMID: 24390215
  • The SmgGDS splice variant SmgGDS-558 is a key promoter of tumor growth and RhoA signaling in breast cancer. (Hauser AD, Bergom C, Schuld NJ, Chen X, Lorimer EL, Huang J, Mackinnon AC, Williams CL) Mol Cancer Res 2014 Jan;12(1):130-42 PMID: 24197117 PMCID: PMC4285378
  • Mitochondria-targeted vitamin E analogs inhibit breast cancer cell energy metabolism and promote cell death. (Cheng G, Zielonka J, McAllister DM, Mackinnon AC Jr, Joseph J, Dwinell MB, Kalyanaraman B) BMC Cancer 2013;13:285 PMID: 23764021 PMCID: PMC3686663
  • Tracking in anatomic pathology. (Pantanowitz L, Mackinnon AC Jr, Sinard JH) Arch Pathol Lab Med 2013 Dec;137(12):1798-810 PMID: 23634908
  • Use of combination chemotherapy for treatment of granulomatous and lymphocytic interstitial lung disease (GLILD) in patients with common variable immunodeficiency (CVID). (Chase NM, Verbsky JW, Hintermeyer MK, Waukau JK, Tomita-Mitchell A, Casper JT, Singh S, Shahir KS, Tisol WB, Nugent ML, Rao RN, Mackinnon AC, Goodman LR, Simpson PM, Routes JM) J Clin Immunol 2013 Jan;33(1):30-9 PMID: 22930256 PMCID: PMC3557581
  • Certification in molecular pathology in the United States: an update from the Association for Molecular Pathology Training and Education Committee. (Mackinnon AC Jr, Wang YL, Sahota A, Yeung CC, Weck KE) J Mol Diagn 2012 Nov;14(6):541-9 PMID: 22925695
  • Extracolonic gastrointestinal tract morphologic findings in a case of pseudomembranous collagenous colitis. (Fons ME, Stein DJ, Patel A, Ferrer MS, Ammon H, Mackinnon AC, Komorowski RA, Yan BC) Ann Diagn Pathol 2013 Jun;17(3):291-4 PMID: 22658854
  • Disseminated Nocardia farcinica: literature review and fatal outcome in an immunocompetent patient. (Budzik JM, Hosseini M, Mackinnon AC Jr, Taxy JB) Surg Infect (Larchmt) 2012 Jun;13(3):163-70 PMID: 22612440 PMCID: PMC3375863
  • Mitochondria-targeted drugs synergize with 2-deoxyglucose to trigger breast cancer cell death. (Cheng G, Zielonka J, Dranka BP, McAllister D, Mackinnon AC Jr, Joseph J, Kalyanaraman B) Cancer Res 2012 May 15;72(10):2634-44 PMID: 22431711 PMCID: PMC3700358
  • Transcription factor genes Smad4 and Gata4 cooperatively regulate cardiac valve development. [corrected] (Moskowitz IP, Wang J, Peterson MA, Pu WT, Mackinnon AC, Oxburgh L, Chu GC, Sarkar M, Berul C, Smoot L, Robertson EJ, Schwartz R, Seidman JG, Seidman CE) Proc Natl Acad Sci U S A 2011 Mar 8;108(10):4006-11 PMID: 21330551 PMCID: PMC3053967
  • Paxillin expression and amplification in early lung lesions of high-risk patients, lung adenocarcinoma and metastatic disease. (Mackinnon AC, Tretiakova M, Henderson L, Mehta RG, Yan BC, Joseph L, Krausz T, Husain AN, Reid ME, Salgia R) J Clin Pathol 2011 Jan;64(1):16-24 PMID: 21045234 PMCID: PMC3002839
  • Ets1 is required for proper migration and differentiation of the cardiac neural crest. (Gao Z, Kim GH, Mackinnon AC, Flagg AE, Bassett B, Earley JU, Svensson EC) Development 2010 May;137(9):1543-51 PMID: 20356956 PMCID: PMC2853851
  • Identification of histologically distinct conventional adenomas that arise predominately in patients with sessile serrated adenomas. (Pai RK, Mackinnon AC, Joseph L, Noffsinger A, Hart J) Am J Surg Pathol 2010 Mar;34(3):355-63 PMID: 20118768
  • Update in nonneoplastic lung diseases. (Gordon IO, Cipriani N, Arif Q, Mackinnon AC, Husain AN) Arch Pathol Lab Med 2009 Jul;133(7):1096-105 PMID: 19642736
  • Molecular biology underlying the clinical heterogeneity of prostate cancer: an update. (Mackinnon AC, Yan BC, Joseph LJ, Al-Ahmadie HA) Arch Pathol Lab Med 2009 Jul;133(7):1033-40 PMID: 19642730
  • Recent developments in the pathology of renal tumors: morphology and molecular characteristics of select entities. (Yan BC, Mackinnon AC, Al-Ahmadie HA) Arch Pathol Lab Med 2009 Jul;133(7):1026-32 PMID: 19642729
  • Update in neoplastic lung diseases and mesothelioma. (Gordon IO, Sitterding S, Mackinnon AC, Husain AN) Arch Pathol Lab Med 2009 Jul;133(7):1106-15 PMID: 19642737
  • Expression and mutational analysis of MET in human solid cancers. (Ma PC, Tretiakova MS, MacKinnon AC, Ramnath N, Johnson C, Dietrich S, Seiwert T, Christensen JG, Jagadeeswaran R, Krausz T, Vokes EE, Husain AN, Salgia R) Genes Chromosomes Cancer 2008 Dec;47(12):1025-37 PMID: 18709663 PMCID: PMC2583960
  • Paxillin is a target for somatic mutations in lung cancer: implications for cell growth and invasion. (Jagadeeswaran R, Surawska H, Krishnaswamy S, Janamanchi V, Mackinnon AC, Seiwert TY, Loganathan S, Kanteti R, Reichman T, Nallasura V, Schwartz S, Faoro L, Wang YC, Girard L, Tretiakova MS, Ahmed S, Zumba O, Soulii L, Bindokas VP, Szeto LL, Gordon GJ, Bueno R, Sugarbaker D, Lingen MW, Sattler M, Krausz T, Vigneswaran W, Natarajan V, Minna J, Vokes EE, Ferguson MK, Husain AN, Salgia R) Cancer Res 2008 Jan 1;68(1):132-42 PMID: 18172305 PMCID: PMC2767335
  • C. elegans PAT-4/ILK functions as an adaptor protein within integrin adhesion complexes. (Mackinnon AC, Qadota H, Norman KR, Moerman DG, Williams BD) Curr Biol 2002 May 14;12(10):787-97 PMID: 12015115
  • Last update: 05/26/2015