Medical College of Wisconsin
CTSICores SearchResearch InformaticsREDCap

Alexander C. Mackinnon Jr MD, PhD

Alexander C. Mackinnon Jr MD, PhD

Associate Professor

Institution: Medical College of Wisconsin
Department: Pathology
Division: Administration

Member of the Cancer Center


  • Immune Check Point Inhibition in Sarcomatoid Renal Cell Carcinoma: A New Treatment Paradigm. (Raychaudhuri R, Riese MJ, Bylow K, Burfeind J, Mackinnon AC, Tolat PP, Iczkowski KA, Kilari D) Clin Genitourin Cancer 2017 May 25 PMID: 28645484 06/25/2017
  • Cancer cell chemokines direct chemotaxis of activated stellate cells in pancreatic ductal adenocarcinoma. (Roy I, Boyle KA, Vonderhaar EP, Zimmerman NP, Gorse E, Mackinnon AC, Hwang RF, Franco-Barraza J, Cukierman E, Tsai S, Evans DB, Dwinell MB) Lab Invest 2017 Mar;97(3):302-317 PMID: 28092365 PMCID: PMC5334280 01/17/2017
  • Association of microRNA 146 with middle ear hyperplasia in pediatric otitis media. (Samuels TL, Yan J, Khampang P, MacKinnon A, Hong W, Johnston N, Kerschner JE) Int J Pediatr Otorhinolaryngol 2016 Sep;88:104-8 PMID: 27497395 PMCID: PMC4978186 08/09/2016
  • A single center's approach to discriminating donor versus host origin of renal neoplasia in the allograft kidney. (Robin AJ, Cohen EP, Chongkrairatanakul T, Saad E, Mackinnon AC) Ann Diagn Pathol 2016 Aug;23:32-4 PMID: 27402221 07/13/2016
  • The tumor-suppressive small GTPase DiRas1 binds the noncanonical guanine nucleotide exchange factor SmgGDS and antagonizes SmgGDS interactions with oncogenic small GTPases. (Bergom C, Hauser AD, Rymaszewski A, Gonyo P, Prokop JW, Jennings BC, Lawton AJ, Frei A, Lorimer EL, Aguilera-Barrantes I, Mackinnon AC Jr, Noon K, Fierke CA, Williams CL) J Biol Chem 2016 May 13;291(20):10948 PMID: 27197236 PMCID: PMC4865938 05/20/2016
  • Dysregulation of WNT5A/ROR2 Signaling Characterizes the Progression of Barrett-Associated Esophageal Adenocarcinoma. (Lyros O, Nie L, Moore T, Medda R, Otterson M, Behmaram B, Mackinnon A, Gockel I, Shaker R, Rafiee P) Mol Cancer Res 2016 Jul;14(7):647-59 PMID: 27084312 04/17/2016
  • The Tumor-suppressive Small GTPase DiRas1 Binds the Noncanonical Guanine Nucleotide Exchange Factor SmgGDS and Antagonizes SmgGDS Interactions with Oncogenic Small GTPases. (Bergom C, Hauser AD, Rymaszewski A, Gonyo P, Prokop JW, Jennings BC, Lawton AJ, Frei A, Lorimer EL, Aguilera-Barrantes I, Mackinnon AC, Noon K, Fierke CA, Williams CL) J Biol Chem 2016 Mar 18;291(12):6534-45 PMID: 26814130 PMCID: PMC4813585 01/28/2016
  • Desmoplastic melanoma: an updated immunohistochemical analysis of 40 cases with a proposal for an additional panel of stains for diagnosis. (Plaza JA, Bonneau P, Prieto V, Sangueza M, Mackinnon A, Suster D, Bacchi C, Estrozi B, Kazakov D, Kacerovska D, Falconieri G, Suster S) J Cutan Pathol 2016 Apr;43(4):313-23 PMID: 26661921 12/15/2015
  • Role of immunohistochemistry in the diagnosis of sebaceous carcinoma: a clinicopathologic and immunohistochemical study. (Plaza JA, Mackinnon A, Carrillo L, Prieto VG, Sangueza M, Suster S) Am J Dermatopathol 2015 Nov;37(11):809-21 PMID: 26485238 10/21/2015
  • Comparing gene expression data from formalin-fixed, paraffin embedded tissues and qPCR with that from snap-frozen tissue and microarrays for modeling outcomes of patients with ovarian carcinoma. (Bradley WH, Eng K, Le M, Mackinnon AC, Kendziorski C, Rader JS) BMC Clin Pathol 2015;15:17 PMID: 26412982 PMCID: PMC4582729 09/29/2015
  • Wnt/β-Catenin Signaling Activation beyond Robust Nuclear β-Catenin Accumulation in Nondysplastic Barrett's Esophagus: Regulation via Dickkopf-1. (Lyros O, Rafiee P, Nie L, Medda R, Jovanovic N, Otterson MF, Behmaram B, Gockel I, Mackinnon A, Shaker R) Neoplasia 2015 Jul;17(7):598-611 PMID: 26297437 PMCID: PMC4547437 08/25/2015
  • Genomic variations in plasma cell free DNA differentiate early stage lung cancers from normal controls. (Xia S, Huang CC, Le M, Dittmar R, Du M, Yuan T, Guo Y, Wang Y, Wang X, Tsai S, Suster S, Mackinnon AC, Wang L) Lung Cancer 2015 Oct;90(1):78-84 PMID: 26233568 08/04/2015
  • Granulomatous and lymphocytic interstitial lung disease: a spectrum of pulmonary histopathologic lesions in common variable immunodeficiency--histologic and immunohistochemical analyses of 16 cases. (Rao N, Mackinnon AC, Routes JM) Hum Pathol 2015 Sep;46(9):1306-14 PMID: 26138782 PMCID: PMC4554947 07/04/2015
  • Spindle Cell Atypical Fibroxanthoma: Myofibroblastic Differentiation Represents a Diagnostic Pitfall in This Variant of AFX. (Harding-Jackson N, Sangueza M, Mackinnon A, Suster S, Plaza JA) Am J Dermatopathol 2015 Jul;37(7):509-14; quiz 515-6 PMID: 26098709 06/23/2015
  • Depletion of M2-like tumor-associated macrophages delays cutaneous T-cell lymphoma development in vivo. (Wu X, Schulte BC, Zhou Y, Haribhai D, Mackinnon AC, Plaza JA, Williams CB, Hwang ST) J Invest Dermatol 2014 Nov;134(11):2814-2822 PMID: 24780929 05/02/2014
  • Antral atrophy, intestinal metaplasia, and preneoplastic markers in Mexican children with Helicobacter pylori-positive and Helicobacter pylori-negative gastritis. (Villarreal-Calderon R, Luévano-González A, Aragón-Flores M, Zhu H, Yuan Y, Xiang Q, Yan B, Stoll KA, Cross JV, Iczkowski KA, Mackinnon AC Jr) Ann Diagn Pathol 2014 Jun;18(3):129-35 PMID: 24656654 PMCID: PMC4516036 03/25/2014
  • CXCL12 chemokine expression suppresses human pancreatic cancer growth and metastasis. (Roy I, Zimmerman NP, Mackinnon AC, Tsai S, Evans DB, Dwinell MB) PLoS One 2014;9(3):e90400 PMID: 24594697 PMCID: PMC3942415 03/07/2014
  • Dickkopf-1, the Wnt antagonist, is induced by acidic pH and mediates epithelial cellular senescence in human reflux esophagitis. (Lyros O, Rafiee P, Nie L, Medda R, Jovanovic N, Schmidt J, Mackinnon A, Venu N, Shaker R) Am J Physiol Gastrointest Liver Physiol 2014 Apr 01;306(7):G557-74 PMID: 24481601 PMCID: PMC3962590 02/01/2014
  • Cribriform adenocarcinoma of the lung: clinicopathologic, immunohistochemical, and molecular analysis of 15 cases of a distinctive morphologic subtype of lung adenocarcinoma. (Mackinnon AC Jr, Luevano A, de Araujo LC, Rao N, Le M, Suster S) Mod Pathol 2014 Aug;27(8):1063-72 PMID: 24390215 01/07/2014
  • The SmgGDS splice variant SmgGDS-558 is a key promoter of tumor growth and RhoA signaling in breast cancer. (Hauser AD, Bergom C, Schuld NJ, Chen X, Lorimer EL, Huang J, Mackinnon AC, Williams CL) Mol Cancer Res 2014 Jan;12(1):130-42 PMID: 24197117 PMCID: PMC4285378 11/08/2013
  • Mitochondria-targeted vitamin E analogs inhibit breast cancer cell energy metabolism and promote cell death. (Cheng G, Zielonka J, McAllister DM, Mackinnon AC Jr, Joseph J, Dwinell MB, Kalyanaraman B) BMC Cancer 2013 Jun 13;13:285 PMID: 23764021 PMCID: PMC3686663 06/15/2013
  • Tracking in anatomic pathology. (Pantanowitz L, Mackinnon AC Jr, Sinard JH) Arch Pathol Lab Med 2013 Dec;137(12):1798-810 PMID: 23634908 05/03/2013
  • Use of combination chemotherapy for treatment of granulomatous and lymphocytic interstitial lung disease (GLILD) in patients with common variable immunodeficiency (CVID). (Chase NM, Verbsky JW, Hintermeyer MK, Waukau JK, Tomita-Mitchell A, Casper JT, Singh S, Shahir KS, Tisol WB, Nugent ML, Rao RN, Mackinnon AC, Goodman LR, Simpson PM, Routes JM) J Clin Immunol 2013 Jan;33(1):30-9 PMID: 22930256 PMCID: PMC3557581 08/30/2012
  • Certification in molecular pathology in the United States: an update from the Association for Molecular Pathology Training and Education Committee. (Mackinnon AC Jr, Wang YL, Sahota A, Yeung CC, Weck KE) J Mol Diagn 2012 Nov;14(6):541-9 PMID: 22925695 08/29/2012
  • Extracolonic gastrointestinal tract morphologic findings in a case of pseudomembranous collagenous colitis. (Fons ME, Stein DJ, Patel A, Ferrer MS, Ammon H, Mackinnon AC, Komorowski RA, Yan BC) Ann Diagn Pathol 2013 Jun;17(3):291-4 PMID: 22658854 06/05/2012
  • Disseminated Nocardia farcinica: literature review and fatal outcome in an immunocompetent patient. (Budzik JM, Hosseini M, Mackinnon AC Jr, Taxy JB) Surg Infect (Larchmt) 2012 Jun;13(3):163-70 PMID: 22612440 PMCID: PMC3375863 05/23/2012
  • Mitochondria-targeted drugs synergize with 2-deoxyglucose to trigger breast cancer cell death. (Cheng G, Zielonka J, Dranka BP, McAllister D, Mackinnon AC Jr, Joseph J, Kalyanaraman B) Cancer Res 2012 May 15;72(10):2634-44 PMID: 22431711 PMCID: PMC3700358 03/21/2012
  • Transcription factor genes Smad4 and Gata4 cooperatively regulate cardiac valve development. [corrected] (Moskowitz IP, Wang J, Peterson MA, Pu WT, Mackinnon AC, Oxburgh L, Chu GC, Sarkar M, Berul C, Smoot L, Robertson EJ, Schwartz R, Seidman JG, Seidman CE) Proc Natl Acad Sci U S A 2011 Mar 08;108(10):4006-11 PMID: 21330551 PMCID: PMC3053967 02/19/2011
  • Paxillin expression and amplification in early lung lesions of high-risk patients, lung adenocarcinoma and metastatic disease. (Mackinnon AC, Tretiakova M, Henderson L, Mehta RG, Yan BC, Joseph L, Krausz T, Husain AN, Reid ME, Salgia R) J Clin Pathol 2011 Jan;64(1):16-24 PMID: 21045234 PMCID: PMC3002839 11/04/2010
  • Ets1 is required for proper migration and differentiation of the cardiac neural crest. (Gao Z, Kim GH, Mackinnon AC, Flagg AE, Bassett B, Earley JU, Svensson EC) Development 2010 May;137(9):1543-51 PMID: 20356956 PMCID: PMC2853851 04/02/2010
  • Identification of histologically distinct conventional adenomas that arise predominately in patients with sessile serrated adenomas. (Pai RK, Mackinnon AC, Joseph L, Noffsinger A, Hart J) Am J Surg Pathol 2010 Mar;34(3):355-63 PMID: 20118768 02/02/2010
  • Molecular biology underlying the clinical heterogeneity of prostate cancer: an update. (Mackinnon AC, Yan BC, Joseph LJ, Al-Ahmadie HA) Arch Pathol Lab Med 2009 Jul;133(7):1033-40 PMID: 19642730 08/01/2009
  • Update in neoplastic lung diseases and mesothelioma. (Gordon IO, Sitterding S, Mackinnon AC, Husain AN) Arch Pathol Lab Med 2009 Jul;133(7):1106-15 PMID: 19642737 08/01/2009
  • Update in nonneoplastic lung diseases. (Gordon IO, Cipriani N, Arif Q, Mackinnon AC, Husain AN) Arch Pathol Lab Med 2009 Jul;133(7):1096-105 PMID: 19642736 08/01/2009
  • Recent developments in the pathology of renal tumors: morphology and molecular characteristics of select entities. (Yan BC, Mackinnon AC, Al-Ahmadie HA) Arch Pathol Lab Med 2009 Jul;133(7):1026-32 PMID: 19642729 08/01/2009
  • Expression and mutational analysis of MET in human solid cancers. (Ma PC, Tretiakova MS, MacKinnon AC, Ramnath N, Johnson C, Dietrich S, Seiwert T, Christensen JG, Jagadeeswaran R, Krausz T, Vokes EE, Husain AN, Salgia R) Genes Chromosomes Cancer 2008 Dec;47(12):1025-37 PMID: 18709663 PMCID: PMC2583960 08/19/2008
  • Paxillin is a target for somatic mutations in lung cancer: implications for cell growth and invasion. (Jagadeeswaran R, Surawska H, Krishnaswamy S, Janamanchi V, Mackinnon AC, Seiwert TY, Loganathan S, Kanteti R, Reichman T, Nallasura V, Schwartz S, Faoro L, Wang YC, Girard L, Tretiakova MS, Ahmed S, Zumba O, Soulii L, Bindokas VP, Szeto LL, Gordon GJ, Bueno R, Sugarbaker D, Lingen MW, Sattler M, Krausz T, Vigneswaran W, Natarajan V, Minna J, Vokes EE, Ferguson MK, Husain AN, Salgia R) Cancer Res 2008 Jan 01;68(1):132-42 PMID: 18172305 PMCID: PMC2767335 01/04/2008
  • C. elegans PAT-4/ILK functions as an adaptor protein within integrin adhesion complexes. (Mackinnon AC, Qadota H, Norman KR, Moerman DG, Williams BD) Curr Biol 2002 May 14;12(10):787-97 PMID: 12015115 05/17/2002
  • Development of a coupled VanA/VanX assay: Screening for inhibitors of glycopeptide resistance (Steven D. Pratt, Xiaoling Xuei, Alexander C. Mackinnon, Angela M. Nilius, Dena M. Hensey-Rudloff, Ping Zhong, and Leonard Katz) Journal of Biomolecular Screening Volume 2:241-247 08/01/1996
  • High throughput screen for inhibitors of bacterial DNA topoisomerase I using the scintillation proximity assay (Claude G. Lerner, Anne Y. Chiang Saiki, A. Craig Mackinnon, and Xiaoling Xuei.) Journal of Biomolecular Screening Volume 1: 135-143 07/01/1996
  • Last update: 06/25/2017
    jenkins-FCD Prod-130 96200611f8481f0aa4f84230b11dd74d063847a3