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Alexander C. Mackinnon Jr MD, PhD

Alexander C. Mackinnon Jr MD, PhD

Associate Professor

Institution: Medical College of Wisconsin
Department: Pathology
Division: Administration

Member of the Cancer Center


  • Immunogenomic Landscape Contributes to Hyperprogressive Disease after Anti-PD-1 Immunotherapy for Cancer. (Xiong D, Wang Y, Singavi AK, Mackinnon AC, George B, You M) iScience 2018 Nov 30;9:258-277 PMID: 30439581 PMCID: PMC6234258 11/16/2018    
  • Overexpression of the VRK1 kinase, which is associated with breast cancer, induces a mesenchymal to epithelial transition in mammary epithelial cells. (Mon AM, MacKinnon AC Jr, Traktman P) PLoS One 2018;13(9):e0203397 PMID: 30180179 PMCID: PMC6122820 09/05/2018    
  • Tubulo-papillary adrenocortical adenoma in a patient with familial adenomatous polyposis: A morphologic, ultrastructural and molecular study. (Huang H, Chang J, Rosati S, Geurts J, Mackinnon AC) Hum Pathol 2018 Aug 30 PMID: 30172912 09/03/2018    
  • A Phase II Clinical Trial of Molecular Profiled Neoadjuvant Therapy for Localized Pancreatic Ductal Adenocarcinoma. (Tsai S, Christians KK, George B, Ritch PS, Dua K, Khan A, Mackinnon AC, Tolat P, Ahmad SA, Hall WA, Erickson BA, Evans DB) Ann Surg 2018 Oct;268(4):610-619 PMID: 30080723 08/07/2018    
  • Poorly Differentiated Nonkeratinizing Squamous Cell Carcinoma of the Thymus: Clinicopathologic and Molecular Genetic Study of 25 Cases. (Suster D, Pihan G, Mackinnon AC, Suster S) Am J Surg Pathol 2018 Sep;42(9):1224-1236 PMID: 29975245 07/06/2018    
  • Expression of PD-L1/PD-1 in lymphoepithelioma-like carcinoma of the thymus. (Suster D, Pihan G, Mackinnon AC, Suster S) Mod Pathol 2018 Dec;31(12):1801-1806 PMID: 29973653 07/06/2018    
  • Bronchiolar Adenoma: Expansion of the Concept of Ciliated Muconodular Papillary Tumors With Proposal for Revised Terminology Based on Morphologic, Immunophenotypic, and Genomic Analysis of 25 Cases. (Chang JC, Montecalvo J, Borsu L, Lu S, Larsen BT, Wallace WD, Sae-Ow W, Mackinnon AC, Kim HR, Bowman A, Sauter JL, Arcila ME, Ladanyi M, Travis WD, Rekhtman N) Am J Surg Pathol 2018 Aug;42(8):1010-1026 PMID: 29846186 05/31/2018    
  • A-C Estrogens as Potent and Selective Estrogen Receptor-Beta Agonists (SERBAs) to Enhance Memory Consolidation under Low-Estrogen Conditions. (Hanson AM, Perera KLIS, Kim J, Pandey RK, Sweeney N, Lu X, Imhoff A, Mackinnon AC, Wargolet AJ, Van Hart RM, Frick KM, Donaldson WA, Sem DS) J Med Chem 2018 Jun 14;61(11):4720-4738 PMID: 29741891 05/10/2018    
  • Optimized -value selection for the discrimination of prostate cancer grades, including the cribriform pattern, using diffusion weighted imaging. (Hurrell SL, McGarry SD, Kaczmarowski A, Iczkowski KA, Jacobsohn K, Hohenwalter MD, Hall WA, See WA, Banerjee A, Charles DK, Nevalainen MT, Mackinnon AC, LaViolette PS) J Med Imaging (Bellingham) 2018 01;5(1):011004 PMID: 29098169 PMCID: PMC5658575 11/04/2017    
  • Evaluation of CD43 expression in non-hematopoietic malignancies. (Batdorf BH, Kroft SH, Hosking PR, Harrington AM, Mackinnon AC, Olteanu H) Ann Diagn Pathol 2017 Aug;29:23-27 PMID: 28807337 08/16/2017    
  • Immune Check Point Inhibition in Sarcomatoid Renal Cell Carcinoma: A New Treatment Paradigm. (Raychaudhuri R, Riese MJ, Bylow K, Burfeind J, Mackinnon AC, Tolat PP, Iczkowski KA, Kilari D) Clin Genitourin Cancer 2017 10;15(5):e897-e901 PMID: 28645484 06/25/2017       2 Citations
  • Cancer cell chemokines direct chemotaxis of activated stellate cells in pancreatic ductal adenocarcinoma. (Roy I, Boyle KA, Vonderhaar EP, Zimmerman NP, Gorse E, Mackinnon AC, Hwang RF, Franco-Barraza J, Cukierman E, Tsai S, Evans DB, Dwinell MB) Lab Invest 2017 03;97(3):302-317 PMID: 28092365 PMCID: PMC5334280 01/17/2017       4 Citations
  • Association of microRNA 146 with middle ear hyperplasia in pediatric otitis media. (Samuels TL, Yan J, Khampang P, MacKinnon A, Hong W, Johnston N, Kerschner JE) Int J Pediatr Otorhinolaryngol 2016 Sep;88:104-8 PMID: 27497395 PMCID: PMC4978186 08/09/2016       3 Citations
  • A single center's approach to discriminating donor versus host origin of renal neoplasia in the allograft kidney. (Robin AJ, Cohen EP, Chongkrairatanakul T, Saad E, Mackinnon AC) Ann Diagn Pathol 2016 Aug;23:32-4 PMID: 27402221 07/13/2016       1 Citations
  • The tumor-suppressive small GTPase DiRas1 binds the noncanonical guanine nucleotide exchange factor SmgGDS and antagonizes SmgGDS interactions with oncogenic small GTPases. (Bergom C, Hauser AD, Rymaszewski A, Gonyo P, Prokop JW, Jennings BC, Lawton AJ, Frei A, Lorimer EL, Aguilera-Barrantes I, Mackinnon AC Jr, Noon K, Fierke CA, Williams CL) J Biol Chem 2016 May 13;291(20):10948 PMID: 27197236 PMCID: PMC4865938 05/20/2016    
  • Dysregulation of WNT5A/ROR2 Signaling Characterizes the Progression of Barrett-Associated Esophageal Adenocarcinoma. (Lyros O, Nie L, Moore T, Medda R, Otterson M, Behmaram B, Mackinnon A, Gockel I, Shaker R, Rafiee P) Mol Cancer Res 2016 07;14(7):647-59 PMID: 27084312 04/17/2016       4 Citations
  • The Tumor-suppressive Small GTPase DiRas1 Binds the Noncanonical Guanine Nucleotide Exchange Factor SmgGDS and Antagonizes SmgGDS Interactions with Oncogenic Small GTPases. (Bergom C, Hauser AD, Rymaszewski A, Gonyo P, Prokop JW, Jennings BC, Lawton AJ, Frei A, Lorimer EL, Aguilera-Barrantes I, Mackinnon AC, Noon K, Fierke CA, Williams CL) J Biol Chem 2016 Mar 18;291(12):6534-45 PMID: 26814130 PMCID: PMC4813585 01/28/2016       9 Citations
  • Desmoplastic melanoma: an updated immunohistochemical analysis of 40 cases with a proposal for an additional panel of stains for diagnosis. (Plaza JA, Bonneau P, Prieto V, Sangueza M, Mackinnon A, Suster D, Bacchi C, Estrozi B, Kazakov D, Kacerovska D, Falconieri G, Suster S) J Cutan Pathol 2016 Apr;43(4):313-23 PMID: 26661921 12/15/2015       13 Citations
  • Role of immunohistochemistry in the diagnosis of sebaceous carcinoma: a clinicopathologic and immunohistochemical study. (Plaza JA, Mackinnon A, Carrillo L, Prieto VG, Sangueza M, Suster S) Am J Dermatopathol 2015 Nov;37(11):809-21 PMID: 26485238 10/21/2015       19 Citations
  • Comparing gene expression data from formalin-fixed, paraffin embedded tissues and qPCR with that from snap-frozen tissue and microarrays for modeling outcomes of patients with ovarian carcinoma. (Bradley WH, Eng K, Le M, Mackinnon AC, Kendziorski C, Rader JS) BMC Clin Pathol 2015;15:17 PMID: 26412982 PMCID: PMC4582729 09/29/2015    
  • Wnt/β-Catenin Signaling Activation beyond Robust Nuclear β-Catenin Accumulation in Nondysplastic Barrett's Esophagus: Regulation via Dickkopf-1. (Lyros O, Rafiee P, Nie L, Medda R, Jovanovic N, Otterson MF, Behmaram B, Gockel I, Mackinnon A, Shaker R) Neoplasia 2015 Jul;17(7):598-611 PMID: 26297437 PMCID: PMC4547437 08/25/2015       10 Citations
  • Genomic variations in plasma cell free DNA differentiate early stage lung cancers from normal controls. (Xia S, Huang CC, Le M, Dittmar R, Du M, Yuan T, Guo Y, Wang Y, Wang X, Tsai S, Suster S, Mackinnon AC, Wang L) Lung Cancer 2015 Oct;90(1):78-84 PMID: 26233568 08/04/2015       15 Citations
  • Granulomatous and lymphocytic interstitial lung disease: a spectrum of pulmonary histopathologic lesions in common variable immunodeficiency--histologic and immunohistochemical analyses of 16 cases. (Rao N, Mackinnon AC, Routes JM) Hum Pathol 2015 Sep;46(9):1306-14 PMID: 26138782 PMCID: PMC4554947 07/04/2015       18 Citations
  • Spindle Cell Atypical Fibroxanthoma: Myofibroblastic Differentiation Represents a Diagnostic Pitfall in This Variant of AFX. (Harding-Jackson N, Sangueza M, Mackinnon A, Suster S, Plaza JA) Am J Dermatopathol 2015 Jul;37(7):509-14; quiz 515-6 PMID: 26098709 06/23/2015       5 Citations
  • Prostate cancer risk locus at 8q24 as a regulatory hub by physical interactions with multiple genomic loci across the genome. (Du M, Yuan T, Schilter KF, Dittmar RL, Mackinnon A, Huang X, Tschannen M, Worthey E, Jacob H, Xia S, Gao J, Tillmans L, Lu Y, Liu P, Thibodeau SN, Wang L) Hum Mol Genet 2015 Jan 01;24(1):154-66 PMID: 25149474 PMCID: PMC4262497 08/26/2014       23 Citations
  • Depletion of M2-like tumor-associated macrophages delays cutaneous T-cell lymphoma development in vivo. (Wu X, Schulte BC, Zhou Y, Haribhai D, Mackinnon AC, Plaza JA, Williams CB, Hwang ST) J Invest Dermatol 2014 Nov;134(11):2814-2822 PMID: 24780929 05/02/2014       40 Citations
  • Antral atrophy, intestinal metaplasia, and preneoplastic markers in Mexican children with Helicobacter pylori-positive and Helicobacter pylori-negative gastritis. (Villarreal-Calderon R, Luévano-González A, Aragón-Flores M, Zhu H, Yuan Y, Xiang Q, Yan B, Stoll KA, Cross JV, Iczkowski KA, Mackinnon AC Jr) Ann Diagn Pathol 2014 Jun;18(3):129-35 PMID: 24656654 PMCID: PMC4516036 03/25/2014       6 Citations
  • CXCL12 chemokine expression suppresses human pancreatic cancer growth and metastasis. (Roy I, Zimmerman NP, Mackinnon AC, Tsai S, Evans DB, Dwinell MB) PLoS One 2014;9(3):e90400 PMID: 24594697 PMCID: PMC3942415 03/07/2014       37 Citations
  • Dickkopf-1, the Wnt antagonist, is induced by acidic pH and mediates epithelial cellular senescence in human reflux esophagitis. (Lyros O, Rafiee P, Nie L, Medda R, Jovanovic N, Schmidt J, Mackinnon A, Venu N, Shaker R) Am J Physiol Gastrointest Liver Physiol 2014 Apr 01;306(7):G557-74 PMID: 24481601 PMCID: PMC3962590 02/01/2014       10 Citations
  • Cribriform adenocarcinoma of the lung: clinicopathologic, immunohistochemical, and molecular analysis of 15 cases of a distinctive morphologic subtype of lung adenocarcinoma. (Mackinnon AC Jr, Luevano A, de Araujo LC, Rao N, Le M, Suster S) Mod Pathol 2014 Aug;27(8):1063-72 PMID: 24390215 01/07/2014       16 Citations
  • The SmgGDS splice variant SmgGDS-558 is a key promoter of tumor growth and RhoA signaling in breast cancer. (Hauser AD, Bergom C, Schuld NJ, Chen X, Lorimer EL, Huang J, Mackinnon AC, Williams CL) Mol Cancer Res 2014 Jan;12(1):130-42 PMID: 24197117 PMCID: PMC4285378 11/08/2013       14 Citations
  • Mitochondria-targeted vitamin E analogs inhibit breast cancer cell energy metabolism and promote cell death. (Cheng G, Zielonka J, McAllister DM, Mackinnon AC Jr, Joseph J, Dwinell MB, Kalyanaraman B) BMC Cancer 2013 Jun 13;13:285 PMID: 23764021 PMCID: PMC3686663 06/15/2013       50 Citations
  • Tracking in anatomic pathology. (Pantanowitz L, Mackinnon AC Jr, Sinard JH) Arch Pathol Lab Med 2013 Dec;137(12):1798-810 PMID: 23634908 05/03/2013    
  • Use of combination chemotherapy for treatment of granulomatous and lymphocytic interstitial lung disease (GLILD) in patients with common variable immunodeficiency (CVID). (Chase NM, Verbsky JW, Hintermeyer MK, Waukau JK, Tomita-Mitchell A, Casper JT, Singh S, Shahir KS, Tisol WB, Nugent ML, Rao RN, Mackinnon AC, Goodman LR, Simpson PM, Routes JM) J Clin Immunol 2013 Jan;33(1):30-9 PMID: 22930256 PMCID: PMC3557581 08/30/2012       85 Citations
  • Certification in molecular pathology in the United States: an update from the Association for Molecular Pathology Training and Education Committee. (Mackinnon AC Jr, Wang YL, Sahota A, Yeung CC, Weck KE) J Mol Diagn 2012 Nov;14(6):541-9 PMID: 22925695 08/29/2012       3 Citations
  • Extracolonic gastrointestinal tract morphologic findings in a case of pseudomembranous collagenous colitis. (Fons ME, Stein DJ, Patel A, Ferrer MS, Ammon H, Mackinnon AC, Komorowski RA, Yan BC) Ann Diagn Pathol 2013 Jun;17(3):291-4 PMID: 22658854 06/05/2012       2 Citations
  • Disseminated Nocardia farcinica: literature review and fatal outcome in an immunocompetent patient. (Budzik JM, Hosseini M, Mackinnon AC Jr, Taxy JB) Surg Infect (Larchmt) 2012 Jun;13(3):163-70 PMID: 22612440 PMCID: PMC3375863 05/23/2012       21 Citations
  • Mitochondria-targeted drugs synergize with 2-deoxyglucose to trigger breast cancer cell death. (Cheng G, Zielonka J, Dranka BP, McAllister D, Mackinnon AC Jr, Joseph J, Kalyanaraman B) Cancer Res 2012 May 15;72(10):2634-44 PMID: 22431711 PMCID: PMC3700358 03/21/2012       114 Citations
  • Transcription factor genes Smad4 and Gata4 cooperatively regulate cardiac valve development. [corrected] (Moskowitz IP, Wang J, Peterson MA, Pu WT, Mackinnon AC, Oxburgh L, Chu GC, Sarkar M, Berul C, Smoot L, Robertson EJ, Schwartz R, Seidman JG, Seidman CE) Proc Natl Acad Sci U S A 2011 Mar 08;108(10):4006-11 PMID: 21330551 PMCID: PMC3053967 02/19/2011       61 Citations
  • Paxillin expression and amplification in early lung lesions of high-risk patients, lung adenocarcinoma and metastatic disease. (Mackinnon AC, Tretiakova M, Henderson L, Mehta RG, Yan BC, Joseph L, Krausz T, Husain AN, Reid ME, Salgia R) J Clin Pathol 2011 Jan;64(1):16-24 PMID: 21045234 PMCID: PMC3002839 11/04/2010       28 Citations
  • Ets1 is required for proper migration and differentiation of the cardiac neural crest. (Gao Z, Kim GH, Mackinnon AC, Flagg AE, Bassett B, Earley JU, Svensson EC) Development 2010 May;137(9):1543-51 PMID: 20356956 PMCID: PMC2853851 04/02/2010       38 Citations
  • Identification of histologically distinct conventional adenomas that arise predominately in patients with sessile serrated adenomas. (Pai RK, Mackinnon AC, Joseph L, Noffsinger A, Hart J) Am J Surg Pathol 2010 Mar;34(3):355-63 PMID: 20118768 02/02/2010       20 Citations
  • Recent developments in the pathology of renal tumors: morphology and molecular characteristics of select entities. (Yan BC, Mackinnon AC, Al-Ahmadie HA) Arch Pathol Lab Med 2009 Jul;133(7):1026-32 PMID: 19642729 08/01/2009       29 Citations
  • Molecular biology underlying the clinical heterogeneity of prostate cancer: an update. (Mackinnon AC, Yan BC, Joseph LJ, Al-Ahmadie HA) Arch Pathol Lab Med 2009 Jul;133(7):1033-40 PMID: 19642730 08/01/2009       43 Citations
  • Update in neoplastic lung diseases and mesothelioma. (Gordon IO, Sitterding S, Mackinnon AC, Husain AN) Arch Pathol Lab Med 2009 Jul;133(7):1106-15 PMID: 19642737 08/01/2009       11 Citations
  • Update in nonneoplastic lung diseases. (Gordon IO, Cipriani N, Arif Q, Mackinnon AC, Husain AN) Arch Pathol Lab Med 2009 Jul;133(7):1096-105 PMID: 19642736 08/01/2009       6 Citations
  • Expression and mutational analysis of MET in human solid cancers. (Ma PC, Tretiakova MS, MacKinnon AC, Ramnath N, Johnson C, Dietrich S, Seiwert T, Christensen JG, Jagadeeswaran R, Krausz T, Vokes EE, Husain AN, Salgia R) Genes Chromosomes Cancer 2008 Dec;47(12):1025-37 PMID: 18709663 PMCID: PMC2583960 08/19/2008       202 Citations
  • Paxillin is a target for somatic mutations in lung cancer: implications for cell growth and invasion. (Jagadeeswaran R, Surawska H, Krishnaswamy S, Janamanchi V, Mackinnon AC, Seiwert TY, Loganathan S, Kanteti R, Reichman T, Nallasura V, Schwartz S, Faoro L, Wang YC, Girard L, Tretiakova MS, Ahmed S, Zumba O, Soulii L, Bindokas VP, Szeto LL, Gordon GJ, Bueno R, Sugarbaker D, Lingen MW, Sattler M, Krausz T, Vigneswaran W, Natarajan V, Minna J, Vokes EE, Ferguson MK, Husain AN, Salgia R) Cancer Res 2008 Jan 01;68(1):132-42 PMID: 18172305 PMCID: PMC2767335 01/04/2008       86 Citations
  • C. elegans PAT-4/ILK functions as an adaptor protein within integrin adhesion complexes. (Mackinnon AC, Qadota H, Norman KR, Moerman DG, Williams BD) Curr Biol 2002 May 14;12(10):787-97 PMID: 12015115 05/17/2002       216 Citations
  • Development of a coupled VanA/VanX assay: Screening for inhibitors of glycopeptide resistance (Steven D. Pratt, Xiaoling Xuei, Alexander C. Mackinnon, Angela M. Nilius, Dena M. Hensey-Rudloff, Ping Zhong, and Leonard Katz) Journal of Biomolecular Screening Volume 2:241-247 08/01/1996    
  • High throughput screen for inhibitors of bacterial DNA topoisomerase I using the scintillation proximity assay (Claude G. Lerner, Anne Y. Chiang Saiki, A. Craig Mackinnon, and Xiaoling Xuei.) Journal of Biomolecular Screening Volume 1: 135-143 07/01/1996    
  • Last update: 03/11/2019
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