Medical College of Wisconsin
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Alfredo Dubra PhD

Alfredo Dubra PhD

Assistant Professor

Institution: Medical College of Wisconsin
Department: Ophthalmology
Program: Research


Publications

  • Classification of human retinal microaneurysms using adaptive optics scanning light ophthalmoscope fluorescein angiography. (Dubow M, Pinhas A, Shah N, Cooper RF, Gan A, Gentile RC, Hendrix V, Sulai YN, Carroll J, Chui TY, Walsh JB, Weitz R, Dubra A, Rosen RB) Invest Ophthalmol Vis Sci 2014 Mar;55(3):1299-309 PMID 24425852
  • In vivo imaging of retinal pigment epithelium cells in age related macular degeneration. (Rossi EA, Rangel-Fonseca P, Parkins K, Fischer W, Latchney LR, Folwell MA, Williams DR, Dubra A, Chung MM) Biomed Opt Express 2013;4(11):2527-39 PMID 24298413
  • Retinal structure and function in achromatopsia: implications for gene therapy. (Sundaram V, Wilde C, Aboshiha J, Cowing J, Han C, Langlo CS, Chana R, Davidson AE, Sergouniotis PI, Bainbridge JW, Ali RR, Dubra A, Rubin G, Webster AR, Moore AT, Nardini M, Carroll J, Michaelides M) Ophthalmology 2014 Jan;121(1):234-45 PMID 24148654
  • Human cone visual pigment deletions spare sufficient photoreceptors to warrant gene therapy. (Cideciyan AV, Hufnagel RB, Carroll J, Sumaroka A, Luo X, Schwartz SB, Dubra A, Land M, Michaelides M, Gardner JC, Hardcastle AJ, Moore AT, Sisk RA, Ahmed ZM, Kohl S, Wissinger B, Jacobson SG) Hum Gene Ther 2013 Dec;24(12):993-1006 PMID 24067079
  • In vivo dark-field imaging of the retinal pigment epithelium cell mosaic. (Scoles D, Sulai YN, Dubra A) Biomed Opt Express 2013;4(9):1710-23 PMID 24049692
  • In vivo imaging of human retinal microvasculature using adaptive optics scanning light ophthalmoscope fluorescein angiography. (Pinhas A, Dubow M, Shah N, Chui TY, Scoles D, Sulai YN, Weitz R, Walsh JB, Carroll J, Dubra A, Rosen RB) Biomed Opt Express 2013;4(8):1305-17 PMID 24009994
  • A lensing effect of inner retinal cysts on images of the photoreceptor mosaic. (Langlo CS, Flatter JA, Dubra A, Wirostko WJ, Carroll J) Retina 2014 Feb;34(2):421-2 PMID 23974999
  • Outer retinal structure in best vitelliform macular dystrophy. (Kay DB, Land ME, Cooper RF, Dubis AM, Godara P, Dubra A, Carroll J, Stepien KE) JAMA Ophthalmol 2013 Sep;131(9):1207-15 PMID 23765342
  • Automatic cone photoreceptor segmentation using graph theory and dynamic programming. (Chiu SJ, Lokhnygina Y, Dubis AM, Dubra A, Carroll J, Izatt JA, Farsiu S) Biomed Opt Express 2013 Jun 1;4(6):924-37 PMID 23761854
  • Automatic detection of modal spacing (Yellott's ring) in adaptive optics scanning light ophthalmoscope images. (Cooper RF, Langlo CS, Dubra A, Carroll J) Ophthalmic Physiol Opt 2013 Jul;33(4):540-9 PMID 23668233
  • Adaptive optics retinal imaging--clinical opportunities and challenges. (Carroll J, Kay DB, Scoles D, Dubra A, Lombardo M) Curr Eye Res 2013 Jul;38(7):709-21 PMID 23621343
  • Selective cone photoreceptor injury in acute macular neuroretinopathy. (Hansen SO, Cooper RF, Dubra A, Carroll J, Weinberg DV) Retina 2013 Sep;33(8):1650-8 PMID 23615345
  • First-order design of a reflective viewfinder for adaptive optics ophthalmoscopy. (Dubra A, Sulai YN) Opt Express 2012 Nov 19;20(24):26596-605 PMID 23187514
  • The effect of cone opsin mutations on retinal structure and the integrity of the photoreceptor mosaic. (Carroll J, Dubra A, Gardner JC, Mizrahi-Meissonnier L, Cooper RF, Dubis AM, Nordgren R, Genead M, Connor TB Jr, Stepien KE, Sharon D, Hunt DM, Banin E, Hardcastle AJ, Moore AT, Williams DR, Fishman G, Neitz J, Neitz M, Michaelides M) Invest Ophthalmol Vis Sci 2012 Dec;53(13):8006-15 PMID 23139274
  • Assessing retinal structure in complete congenital stationary night blindness and Oguchi disease. (Godara P, Cooper RF, Sergouniotis PI, Diederichs MA, Streb MR, Genead MA, McAnany JJ, Webster AR, Moore AT, Dubis AM, Neitz M, Dubra A, Stone EM, Fishman GA, Han DP, Michaelides M, Carroll J) Am J Ophthalmol 2012 Dec;154(6):987-1001.e1 PMID 22959359
  • Adaptive optics scanning ophthalmoscopy with annular pupils. (Sulai YN, Dubra A) Biomed Opt Express 2012 Jul 1;3(7):1647-61 PMID 22808435
  • Adaptive optics retinal imaging in the living mouse eye. (Geng Y, Dubra A, Yin L, Merigan WH, Sharma R, Libby RT, Williams DR) Biomed Opt Express 2012 Apr 1;3(4):715-34 PMID 22574260
  • Repeatability of in vivo parafoveal cone density and spacing measurements. (Garrioch R, Langlo C, Dubis AM, Cooper RF, Dubra A, Carroll J) Optom Vis Sci 2012 May;89(5):632-43 PMID 22504330
  • Subclinical photoreceptor disruption in response to severe head trauma. (Stepien KE, Martinez WM, Dubis AM, Cooper RF, Dubra A, Carroll J) Arch Ophthalmol 2012 Mar;130(3):400-2 PMID 22411676
  • Relationship between the foveal avascular zone and foveal pit morphology. (Dubis AM, Hansen BR, Cooper RF, Beringer J, Dubra A, Carroll J) Invest Ophthalmol Vis Sci 2012 Mar;53(3):1628-36 PMID 22323466
  • Spatial and temporal variation of rod photoreceptor reflectance in the human retina. (Cooper RF, Dubis AM, Pavaskar A, Rha J, Dubra A, Carroll J) Biomed Opt Express 2011 Sep 1;2(9):2577-89 PMID 21991550
  • Retinal crystals in type 2 idiopathic macular telangiectasia. (Sallo FB, Leung I, Chung M, Wolf-Schnurrbusch UE, Dubra A, Williams DR, Clemons T, Pauleikhoff D, Bird AC, Peto T, MacTel Study Group) Ophthalmology 2011 Dec;118(12):2461-7 PMID 21839520
  • Photoreceptor structure and function in patients with congenital achromatopsia. (Genead MA, Fishman GA, Rha J, Dubis AM, Bonci DM, Dubra A, Stone EM, Neitz M, Carroll J) Invest Ophthalmol Vis Sci 2011 Sep;52(10):7298-308 PMID 21778272
  • Noninvasive imaging of the human rod photoreceptor mosaic using a confocal adaptive optics scanning ophthalmoscope. (Dubra A, Sulai Y, Norris JL, Cooper RF, Dubis AM, Williams DR, Carroll J) Biomed Opt Express 2011 Jul 1;2(7):1864-76 PMID 21750765
  • Reflective afocal broadband adaptive optics scanning ophthalmoscope. (Dubra A, Sulai Y) Biomed Opt Express 2011 Jun 1;2(6):1757-68 PMID 21698035
  • Variability in parafoveal cone mosaic in normal trichromatic individuals. (Dees EW, Dubra A, Baraas RC) Biomed Opt Express 2011;2(5):1351-8 PMID 21559146
  • Optical properties of the mouse eye. (Geng Y, Schery LA, Sharma R, Dubra A, Ahmad K, Libby RT, Williams DR) Biomed Opt Express 2011;2(4):717-38 PMID 21483598
  • Imaging retinal mosaics in the living eye. (Rossi EA, Chung M, Dubra A, Hunter JJ, Merigan WH, Williams DR) Eye (Lond) 2011 Mar;25(3):301-8 PMID 21390064
  • Images of photoreceptors in living primate eyes using adaptive optics two-photon ophthalmoscopy. (Hunter JJ, Masella B, Dubra A, Sharma R, Yin L, Merigan WH, Palczewska G, Palczewski K, Williams DR) Biomed Opt Express 2010;2(1):139-48 PMID 21326644
  • Race- and sex-related differences in retinal thickness and foveal pit morphology. (Wagner-Schuman M, Dubis AM, Nordgren RN, Lei Y, Odell D, Chiao H, Weh E, Fischer W, Sulai Y, Dubra A, Carroll J) Invest Ophthalmol Vis Sci 2011 Jan;52(1):625-34 PMID 20861480
  • First-order design of off-axis reflective ophthalmic adaptive optics systems using afocal telescopes. (Gómez-Vieyra A, Dubra A, Malacara-Hernández D, Williams DR) Opt Express 2009 Oct 12;17(21):18906-19 PMID 20372626
  • In vivo imaging of microscopic structures in the rat retina. (Geng Y, Greenberg KP, Wolfe R, Gray DC, Hunter JJ, Dubra A, Flannery JG, Williams DR, Porter J) Invest Ophthalmol Vis Sci 2009 Dec;50(12):5872-9 PMID 19578019
  • In vivo autofluorescence imaging of the human and macaque retinal pigment epithelial cell mosaic. (Morgan JI, Dubra A, Wolfe R, Merigan WH, Williams DR) Invest Ophthalmol Vis Sci 2009 Mar;50(3):1350-9 PMID 18952914
  • Alternating current sensor with second-harmonic detection. (Ferrari JA, Perciante CD, Dubra A, Arnaud A, Frins EM) Appl Opt 2000 Sep 1;39(25):4638-40 PMID 18350054
  • Precision synchronous polarimeter with linear response for the measurement of small rotation angles. (Arnaud A, Silveira F, Frins EM, Dubra A, Perciante CD, Ferrari JA) Appl Opt 2000 Jun 1;39(16):2601-4 PMID 18345177
  • Current sensor using heterodyne detection. (Ferrari JA, Dubra A, Arnaud A, Perciante D) Appl Opt 1999 May 1;38(13):2808-11 PMID 18319858
  • In vivo imaging of the fine structure of rhodamine-labeled macaque retinal ganglion cells. (Gray DC, Wolfe R, Gee BP, Scoles D, Geng Y, Masella BD, Dubra A, Luque S, Williams DR, Merigan WH) Invest Ophthalmol Vis Sci 2008 Jan;49(1):467-73 PMID 18172127
  • Robust one-beam interferometer with phase-delay control. (Ferrari JA, Frins EM, Perciante D, Dubra A) Opt Lett 1999 Sep 15;24(18):1272-4 PMID 18079777
  • Conversion of bright nondiffracting beams into dark nondiffracting beams by use of the topological properties of polarized light. (Frins EM, Ferrari JA, Dubra A, Perciante D) Opt Lett 2000 Mar 1;25(5):284-6 PMID 18059855
  • Wavefront sensor and wavefront corrector matching in adaptive optics. (Dubra A) Opt Express 2007 Mar 19;15(6):2762-9 PMID 19532513
  • In vivo fluorescence imaging of primate retinal ganglion cells and retinal pigment epithelial cells. (Gray DC, Merigan W, Wolfing JI, Gee BP, Porter J, Dubra A, Twietmeyer TH, Ahamd K, Tumbar R, Reinholz F, Williams DR) Opt Express 2006 Aug 7;14(16):7144-58 PMID 19529085
  • Preisach classical and nonlinear modeling of hysteresis in piezoceramic deformable mirrors. (Dubra A, Massa J, Paterson C) Opt Express 2005 Oct 31;13(22):9062-70 PMID 19498942
  • Double lateral shearing interferometer for the quantitative measurement of tear film topography. (Dubra A, Paterson C, Dainty C) Appl Opt 2005 Mar 1;44(7):1191-9 PMID 15765699
  • Study of the tear topography dynamics using a lateral shearing interferometer. (Dubra A, Paterson C, Dainty C) Opt Express 2004 Dec 13;12(25):6278-88 PMID 19488274
  • Wave-front reconstruction from shear phase maps by use of the discrete Fourier transform. (Dubra A, Paterson C, Dainty C) Appl Opt 2004 Feb 10;43(5):1108-13 PMID 15008490
  • Axial irradiance distribution throughout the whole space behind an annular aperture: comments. (Ferrari JA, Dubra A) Appl Opt 2003 Jul 1;42(19):3754-5; discussion 3792-4 PMID 12868810
  • Grants and Awards

  • Adaptive Optics Retinal Imaging in a Clinical Setting (#9207808 12/11/2012 - 06/30/2014) Sponsor: University of Pennsylvania
  • Research to Prevent Blindness Career Development Award (#9207325 01/01/2012 - 12/31/2015) Sponsor: Research to Prevent Blindness
  • Understanding Eye Disease Through Structural and Functional in Vivo Cellular Imaging of the Retina (#9207269 01/01/2012 - 12/31/2013) Sponsor: Burroughs Wellcome
  • Catalyst for a Cure Research Consortium of the Glaucoma Research Foundation (#9207381 02/15/2012 - 01/31/2015) Sponsor: Glaucoma Research Foundation