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Andrew S. Greene PhD

Andrew S. Greene PhD

Interim Vice Chair, Chief, Professor

Institution: Medical College of Wisconsin
Department: Biomedical Engineering
Program: Biomedical Engineering Program

Member of the Cardiovascular Center


Research Experience

  • Angiogenesis Modulating Agents
  • Biotechnology
  • Endothelial Cells
  • Endothelium
  • Endothelium, Vascular
  • Microcirculation
  • Microscopy
  • Microscopy, Confocal
  • Microscopy, Fluorescence
  • Microscopy, Fluorescence, Multiphoton
  • Proteomics
  • microvascular rarefaction
  • Methodologies and Techniques

  • Microcirculation
  • Publications

  • Isomer-specific effect of microRNA miR-29b on nuclear morphology. (Kriegel AJ, Terhune SS, Greene AS, Noon KR, Pereckas MS, Liang M) J Biol Chem 2018 Sep 07;293(36):14080-14088 PMID: 30006350 PMCID: PMC6130969 07/15/2018    
  • Genome-wide map of proximity linkage to renin proximal promoter in rat. (Stodola TJ, Liu P, Liu Y, Vallejos AK, Geurts AM, Greene AS, Liang M) Physiol Genomics 2018 May 01;50(5):323-331 PMID: 29521603 PMCID: PMC6008118 03/10/2018    
  • Corrigendum to "TRPC3 channels critically regulate hippocampal excitability and contextual fear memory" Behav. Brain Res. 281(March) 2015, 69-77. (Neuner SM, Wilmott LA, Hope KA, Hoffmann B, Chong JA, Abramowitz J, Birnbaumer L, O'Connell K, Tryba AK, Greene AS, Chan CS, Kaczorowski CC) Behav Brain Res 2017 08 14;332:379 PMID: 28576459 06/04/2017    
  • Host genetic modifiers of nonproductive angiogenesis inhibit breast cancer. (Flister MJ, Tsaih SW, Stoddard A, Plasterer C, Jagtap J, Parchur AK, Sharma G, Prisco AR, Lemke A, Murphy D, Al-Gizawiy M, Straza M, Ran S, Geurts AM, Dwinell MR, Greene AS, Bergom C, LaViolette PS, Joshi A) Breast Cancer Res Treat 2017 Aug;165(1):53-64 PMID: 28567545 06/02/2017       2 Citations
  • Mitochondria-regulated formation of endothelium-derived extracellular vesicles shifts the mediator of flow-induced vasodilation. (Freed JK, Durand MJ, Hoffmann BR, Densmore JC, Greene AS, Gutterman DD) Am J Physiol Heart Circ Physiol 2017 May 01;312(5):H1096-H1104 PMID: 28213406 PMCID: PMC5451582 02/19/2017       3 Citations
  • Mechanisms of Mas1 Receptor-Mediated Signaling in the Vascular Endothelium. (Hoffmann BR, Stodola TJ, Wagner JR, Didier DN, Exner EC, Lombard JH, Greene AS) Arterioscler Thromb Vasc Biol 2017 Mar;37(3):433-445 PMID: 28082260 PMCID: PMC5323371 01/14/2017       3 Citations
  • Breaking the Cycle: Estrous Variation Does Not Require Increased Sample Size in the Study of Female Rats. (Dayton A, Exner EC, Bukowy JD, Stodola TJ, Kurth T, Skelton M, Greene AS, Cowley AW Jr) Hypertension 2016 11;68(5):1139-1144 PMID: 27672030 PMCID: PMC5104284 09/28/2016       5 Citations
  • Tumor Necrosis Factor α Regulates Endothelial Progenitor Cell Migration via CADM1 and NF-kB. (Prisco AR, Hoffmann BR, Kaczorowski CC, McDermott-Roe C, Stodola TJ, Exner EC, Greene AS) Stem Cells 2016 07;34(7):1922-33 PMID: 26867147 PMCID: PMC4931961 02/13/2016       5 Citations
  • Functional Local Renin-Angiotensin System in Human and Rat Periodontal Tissue. (Santos CF, Morandini AC, Dionísio TJ, Faria FA, Lima MC, Figueiredo CM, Colombini-Ishikiriama BL, Sipert CR, Maciel RP, Akashi AP, Souza GP, Garlet GP, Rodini CO, Amaral SL, Becari C, Salgado MC, Oliveira EB, Matus I, Didier DN, Greene AS) PLoS One 2015;10(8):e0134601 PMID: 26244896 PMCID: PMC4526652 08/06/2015       3 Citations
  • Genome-wide epigenetic and proteomic analysis reveals altered Notch signaling in EPC dysfunction. (Karcher JR, Hoffmann BR, Liu P, Liu Y, Liang M, Greene AS) Physiol Rep 2015 Apr;3(4) PMID: 25921777 PMCID: PMC4425964 04/30/2015    
  • TNF-α increases endothelial progenitor cell adhesion to the endothelium by increasing bond expression and affinity. (Prisco AR, Prisco MR, Carlson BE, Greene AS) Am J Physiol Heart Circ Physiol 2015 Jun 01;308(11):H1368-81 PMID: 25539711 PMCID: PMC4451300 12/30/2014       8 Citations
  • TRPC3 channels critically regulate hippocampal excitability and contextual fear memory. (Neuner SM, Wilmott LA, Hope KA, Hoffmann B, Chong JA, Abramowitz J, Birnbaumer L, O'Connell KM, Tryba AK, Greene AS, Savio Chan C, Kaczorowski CC) Behav Brain Res 2015 Mar 15;281:69-77 PMID: 25513972 PMCID: PMC4677051 12/17/2014       13 Citations
  • Physiological genomics - where are we now? (Greene AS) Physiol Genomics 2014 Dec 15;46(24):859 PMID: 25492929 12/11/2014       1 Citations
  • Improved rat genome gene prediction by integration of ESTs with RNA-Seq information. (Li L, Chen E, Yang C, Zhu J, Jayaraman P, De Pons J, Kaczorowski CC, Jacob HJ, Greene AS, Hodges MR, Cowley AW Jr, Liang M, Xu H, Liu P, Lu Y) Bioinformatics 2015 Jan 01;31(1):25-32 PMID: 25217576 PMCID: PMC4296142 09/14/2014       2 Citations
  • Automated quantification reveals hyperglycemia inhibits endothelial angiogenic function. (Prisco AR, Bukowy JD, Hoffmann BR, Karcher JR, Exner EC, Greene AS) PLoS One 2014;9(4):e94599 PMID: 24718615 PMCID: PMC3981811 04/11/2014       7 Citations
  • Bone marrow mononuclear cell angiogenic competency is suppressed by a high-salt diet. (Karcher JR, Greene AS) Am J Physiol Cell Physiol 2014 Jan 15;306(2):C123-31 PMID: 24259418 PMCID: PMC3919992 11/22/2013       6 Citations
  • Vascular endothelial growth factor-A signaling in bone marrow-derived endothelial progenitor cells exposed to hypoxic stress. (Hoffmann BR, Wagner JR, Prisco AR, Janiak A, Greene AS) Physiol Genomics 2013 Nov 01;45(21):1021-34 PMID: 24022223 PMCID: PMC3841787 09/12/2013       18 Citations
  • Targeting the endothelial progenitor cell surface proteome to identify novel mechanisms that mediate angiogenic efficacy in a rodent model of vascular disease. (Kaczorowski CC, Stodola TJ, Hoffmann BR, Prisco AR, Liu PY, Didier DN, Karcher JR, Liang M, Jacob HJ, Greene AS) Physiol Genomics 2013 Nov 01;45(21):999-1011 PMID: 24022221 PMCID: PMC3841789 09/12/2013       11 Citations
  • Female-specific hypertension loci on rat chromosome 13. (Hoffman MJ, Flister MJ, Nunez L, Xiao B, Greene AS, Jacob HJ, Moreno C) Hypertension 2013 Sep;62(3):557-63 PMID: 23817491 PMCID: PMC3870583 07/03/2013       11 Citations
  • Hypoxic preconditioning with cobalt of bone marrow mesenchymal stem cells improves cell migration and enhances therapy for treatment of ischemic acute kidney injury. (Yu X, Lu C, Liu H, Rao S, Cai J, Liu S, Kriegel AJ, Greene AS, Liang M, Ding X) PLoS One 2013;8(5):e62703 PMID: 23671625 PMCID: PMC3650042 05/15/2013       50 Citations
  • Chemical proteomics-based analysis of off-target binding profiles for rosiglitazone and pioglitazone: clues for assessing potential for cardiotoxicity. (Hoffmann BR, El-Mansy MF, Sem DS, Greene AS) J Med Chem 2012 Oct 11;55(19):8260-71 PMID: 22970990 PMCID: PMC4113394 09/14/2012       24 Citations
  • Bone marrow mononuclear cells induce beneficial remodeling and reduce diastolic dysfunction in the left ventricle of hypertensive SS/MCWi rats. (Parker SJ, Didier DN, Karcher JR, Stodola TJ, Endres B, Greene AS) Physiol Genomics 2012 Oct 02;44(19):925-33 PMID: 22851760 PMCID: PMC3472462 08/02/2012       6 Citations
  • Mitochondrial proteomic analysis reveals deficiencies in oxygen utilization in medullary thick ascending limb of Henle in the Dahl salt-sensitive rat. (Zheleznova NN, Yang C, Ryan RP, Halligan BD, Liang M, Greene AS, Cowley AW Jr) Physiol Genomics 2012 Sep 01;44(17):829-42 PMID: 22805345 PMCID: PMC3472460 07/19/2012       30 Citations
  • Mechanisms of cardioprotection resulting from Brown Norway chromosome 16 substitution in the salt-sensitive Dahl rat. (Kriegel AJ, Didier DN, Li P, Lazar J, Greene AS) Physiol Genomics 2012 Aug 17;44(16):819-27 PMID: 22759922 PMCID: PMC3774569 07/05/2012       4 Citations
  • Pharmacogenomic strain differences in cardiovascular sensitivity to propofol. (Stekiel TA, Contney SJ, Roman RJ, Weber CA, Stadnicka A, Bosnjak ZJ, Greene AS, Moreno C) Anesthesiology 2011 Dec;115(6):1192-200 PMID: 22020141 PMCID: PMC3245982 10/25/2011       2 Citations
  • Characterization of the genomic structure and function of regions influencing renin and angiogenesis in the SS rat. (Stodola TJ, de Resende MM, Sarkis AB, Didier DN, Jacob HJ, Huebner N, Hummel O, Saar K, Moreno C, Greene AS) Physiol Genomics 2011 Jul 14;43(13):808-17 PMID: 21521778 PMCID: PMC3132840 04/28/2011       4 Citations
  • Visualize: a free and open source multifunction tool for proteomics data analysis. (Halligan BD, Greene AS) Proteomics 2011 Mar;11(6):1058-63 PMID: 21365761 PMCID: PMC3816356 03/03/2011       20 Citations
  • Creation and characterization of a renin knockout rat. (Moreno C, Hoffman M, Stodola TJ, Didier DN, Lazar J, Geurts AM, North PE, Jacob HJ, Greene AS) Hypertension 2011 Mar;57(3):614-9 PMID: 21242461 PMCID: PMC3513323 01/19/2011       46 Citations
  • The importance of being Earnest: I can't glean which gene you mean. (Greene AS) Physiol Genomics 2011 Feb 24;43(4):187 PMID: 21177385 12/24/2010    
  • Impaired relaxation of cerebral arteries in the absence of elevated salt intake in normotensive congenic rats carrying the Dahl salt-sensitive renin gene. (Durand MJ, Moreno C, Greene AS, Lombard JH) Am J Physiol Heart Circ Physiol 2010 Dec;299(6):H1865-74 PMID: 20852041 PMCID: PMC3006280 09/21/2010       15 Citations
  • MicroRNA-target pairs in human renal epithelial cells treated with transforming growth factor beta 1: a novel role of miR-382. (Kriegel AJ, Fang Y, Liu Y, Tian Z, Mladinov D, Matus IR, Ding X, Greene AS, Liang M) Nucleic Acids Res 2010 Dec;38(22):8338-47 PMID: 20716515 PMCID: PMC3001085 08/19/2010       77 Citations
  • Candidate urinary biomarker discovery in ureteropelvic junction obstruction: a proteomic approach. (Mesrobian HG, Mitchell ME, See WA, Halligan BD, Carlson BE, Greene AS, Wakim BT) J Urol 2010 Aug;184(2):709-14 PMID: 20639044 07/20/2010       28 Citations
  • Proteomic analysis of shear stress-mediated protection from TNF-alpha in endothelial cells. (Freed JK, Greene AS) Microcirculation 2010 May;17(4):259-70 PMID: 20536739 PMCID: PMC3712086 06/12/2010       10 Citations
  • Role of the renin angiotensin system on bone marrow-derived stem cell function and its impact on skeletal muscle angiogenesis. (de Resende MM, Stodola TJ, Greene AS) Physiol Genomics 2010 Aug;42(3):437-44 PMID: 20501694 PMCID: PMC2929886 05/27/2010       17 Citations
  • Quantitative analysis of SILAC data sets using spectral counting. (Parker SJ, Halligan BD, Greene AS) Proteomics 2010 Apr;10(7):1408-15 PMID: 20104619 PMCID: PMC4326228 01/28/2010       9 Citations
  • Dynamic convergence and divergence of renal genomic and biological pathways in protection from Dahl salt-sensitive hypertension. (Lu L, Li P, Yang C, Kurth T, Misale M, Skelton M, Moreno C, Roman RJ, Greene AS, Jacob HJ, Lazar J, Liang M, Cowley AW Jr) Physiol Genomics 2010 Mar 03;41(1):63-70 PMID: 20009007 PMCID: PMC2841498 12/17/2009       19 Citations
  • Restoration of cerebral vascular relaxation in renin congenic rats by introgression of the Dahl R renin gene. (Drenjancevic-Peric I, Weinberg BD, Greene AS, Lombard JH) Am J Hypertens 2010 Mar;23(3):243-8 PMID: 19959997 PMCID: PMC2924749 12/05/2009       9 Citations
  • Novel role of fumarate metabolism in dahl-salt sensitive hypertension. (Tian Z, Liu Y, Usa K, Mladinov D, Fang Y, Ding X, Greene AS, Cowley AW Jr, Liang M) Hypertension 2009 Aug;54(2):255-60 PMID: 19546378 PMCID: PMC2721687 06/24/2009       34 Citations
  • Low cost, scalable proteomics data analysis using Amazon's cloud computing services and open source search algorithms. (Halligan BD, Geiger JF, Vallejos AK, Greene AS, Twigger SN) J Proteome Res 2009 Jun;8(6):3148-53 PMID: 19358578 PMCID: PMC2691775 04/11/2009       48 Citations
  • Characterization of a local renin-angiotensin system in rat gingival tissue. (Santos CF, Akashi AE, Dionísio TJ, Sipert CR, Didier DN, Greene AS, Oliveira SH, Pereira HJ, Becari C, Oliveira EB, Salgado MC) J Periodontol 2009 Jan;80(1):130-9 PMID: 19228099 PMCID: PMC2758819 02/21/2009       16 Citations
  • Substitution of Brown Norway chromosome 16 preserves cardiac function with aging in a salt-sensitive Dahl consomic rat. (Kriegel AJ, Greene AS) Physiol Genomics 2008 Dec 12;36(1):35-42 PMID: 18940898 PMCID: PMC2604784 10/23/2008       10 Citations
  • Identification of cell surface markers to differentiate rat endothelial and fibroblast cells using lectin arrays and LC-ESI-MS/MS. (Lee JE, Mirza SP, Didier DN, Scalf M, Olivier M, Greene AS, Smith LM) Anal Chem 2008 Nov 01;80(21):8269-75 PMID: 18821777 PMCID: PMC2950091 09/30/2008       6 Citations
  • Revealing the role of phosphatidylserine in shear stress-mediated protection in endothelial cells. (Freed JK, Shortreed MR, Kleefisch CJ, Smith LM, Greene AS) Endothelium 2008 Jul-Aug;15(4):225-30 PMID: 18663626 PMCID: PMC2579788 07/30/2008       4 Citations
  • Chromosome substitution reveals the genetic basis of Dahl salt-sensitive hypertension and renal disease. (Mattson DL, Dwinell MR, Greene AS, Kwitek AE, Roman RJ, Jacob HJ, Cowley AW Jr) Am J Physiol Renal Physiol 2008 Sep;295(3):F837-42 PMID: 18653478 PMCID: PMC2536867 07/26/2008       64 Citations
  • Protein composition of plasminogen activator inhibitor type 1-derived endothelial microparticles. (Sander TL, Ou JS, Densmore JC, Kaul S, Matus I, Twigger S, Halligan B, Greene AS, Pritchard KA Jr, Oldham KT) Shock 2008 Apr;29(4):504-11 PMID: 18598005 07/04/2008       17 Citations
  • Inhibition of angiogenesis by high salt diet is associated with impaired muscle performance following chronic muscle stimulation. (Petersen MC, Greene AS) Microcirculation 2008 Jul;15(5):405-16 PMID: 18574743 PMCID: PMC2578819 06/25/2008       5 Citations
  • 18O labeling over a coffee break: a rapid strategy for quantitative proteomics. (Mirza SP, Greene AS, Olivier M) J Proteome Res 2008 Jul;7(7):3042-8 PMID: 18510357 PMCID: PMC2771644 05/31/2008       33 Citations
  • Effect of ANG II on endothelial cell apoptosis and survival and its impact on skeletal muscle angiogenesis after electrical stimulation. (de Resende MM, Greene AS) Am J Physiol Heart Circ Physiol 2008 Jun;294(6):H2814-21 PMID: 18441208 PMCID: PMC2579789 04/29/2008       11 Citations
  • Molecular networks in Dahl salt-sensitive hypertension based on transcriptome analysis of a panel of consomic rats. (Liang M, Lee NH, Wang H, Greene AS, Kwitek AE, Kaldunski ML, Luu TV, Frank BC, Bugenhagen S, Jacob HJ, Cowley AW Jr) Physiol Genomics 2008 Jun 12;34(1):54-64 PMID: 18430809 04/24/2008       33 Citations
  • Renal regional proteomes in young Dahl salt-sensitive rats. (Tian Z, Greene AS, Usa K, Matus IR, Bauwens J, Pietrusz JL, Cowley AW Jr, Liang M) Hypertension 2008 Apr;51(4):899-904 PMID: 18316652 03/05/2008       35 Citations
  • A comparison of 2-D chromatography separations using UV and (18)O quantification of proteins in similar proteomes. (Smith JR, Matus I, Greene AS) J Sep Sci 2008 Feb;31(2):314-20 PMID: 18246581 02/05/2008    
  • Differential expression of cardiac mitochondrial proteins. (Smith JR, Matus IR, Beard DA, Greene AS) Proteomics 2008 Feb;8(3):446-62 PMID: 18232060 01/31/2008       9 Citations
  • MicroRNA-target pairs in the rat kidney identified by microRNA microarray, proteomic, and bioinformatic analysis. (Tian Z, Greene AS, Pietrusz JL, Matus IR, Liang M) Genome Res 2008 Mar;18(3):404-11 PMID: 18230805 PMCID: PMC2259104 01/31/2008       161 Citations
  • Congenic strains reveal the effect of the renin gene on skeletal muscle angiogenesis induced by electrical stimulation. (de Resende MM, Amaral SL, Moreno C, Greene AS) Physiol Genomics 2008 Mar 14;33(1):33-40 PMID: 18198281 01/17/2008       14 Citations
  • Chromosomal mapping of the genetic basis of hypertension and renal disease in FHH rats. (Mattson DL, Dwinell MR, Greene AS, Kwitek AE, Roman RJ, Cowley AW Jr, Jacob HJ) Am J Physiol Renal Physiol 2007 Dec;293(6):F1905-14 PMID: 17898042 09/28/2007       37 Citations
  • Angiotensin II is a critical mediator of prazosin-induced angiogenesis in skeletal muscle. (Petersen MC, Greene AS) Microcirculation 2007 Aug;14(6):583-91 PMID: 17710629 PMCID: PMC2579785 08/22/2007       7 Citations
  • PROTEIN COMPOSITION OF PLASMINOGEN ACTIVATOR INHIBITOR TYPE 1-DERIVED ENDOTHELIAL MICROPARTICLES. (Sander TL et al.) Shock 2007 Aug 16;Publish Ahead of Print: PMID: 17704734 08/21/2007    
  • Relative quantification of peptide phosphorylation in a complex mixture using 18O labeling. (Smith JR, Olivier M, Greene AS) Physiol Genomics 2007 Oct 22;31(2):357-63 PMID: 17684036 PMCID: PMC2771636 08/09/2007       19 Citations
  • Characterization of vascular endothelial growth factor receptors on the endothelial cell surface during hypoxia using whole cell binding arrays. (Lee JE, Didier DN, Lockett MR, Scalf M, Greene AS, Olivier M, Smith LM) Anal Biochem 2007 Oct 15;369(2):241-7 PMID: 17624292 PMCID: PMC2706495 07/13/2007       10 Citations
  • Isolation of signal transduction complexes using biotin and crosslinking methodologies. (Freed JK, Smith JR, Li P, Greene AS) Proteomics 2007 Jul;7(14):2371-4 PMID: 17623297 07/12/2007       11 Citations
  • Multiple blood pressure loci on rat chromosome 13 attenuate development of hypertension in the Dahl S hypertensive rat. (Moreno C, Kaldunski ML, Wang T, Roman RJ, Greene AS, Lazar J, Jacob HJ, Cowley AW Jr) Physiol Genomics 2007 Oct 22;31(2):228-35 PMID: 17566075 06/15/2007       52 Citations
  • Prevalence of four putative periodontopathic bacteria in saliva of a group of Brazilian children with mixed dentition: 1-year longitudinal study. (Sakai VT, Campos MR, Machado MA, Lauris JR, Greene AS, Santos CF) Int J Paediatr Dent 2007 May;17(3):192-9 PMID: 17397463 04/03/2007       31 Citations
  • Improved method for the analysis of membrane proteins by mass spectrometry. (Mirza SP, Halligan BD, Greene AS, Olivier M) Physiol Genomics 2007 Jun 19;30(1):89-94 PMID: 17341690 PMCID: PMC2814522 03/08/2007       56 Citations
  • Efficient transgenic rat production by a lentiviral vector. (Michalkiewicz M, Michalkiewicz T, Geurts AM, Roman RJ, Slocum GR, Singer O, Weihrauch D, Greene AS, Kaldunski M, Verma IM, Jacob HJ, Cowley AW Jr) Am J Physiol Heart Circ Physiol 2007 Jul;293(1):H881-94 PMID: 17322424 02/27/2007       35 Citations
  • Combined effects of low-dose spironolactone and captopril therapy in a rat model of genetic hypertrophic cardiomyopathy. (de Resende MM, Kriegel AJ, Greene AS) J Cardiovasc Pharmacol 2006 Dec;48(6):265-73 PMID: 17204904 01/06/2007       21 Citations
  • Improved mass spectrometric proteomic profiling of the secretome of rat vascular endothelial cells. (Pellitteri-Hahn MC, Warren MC, Didier DN, Winkler EL, Mirza SP, Greene AS, Olivier M) J Proteome Res 2006 Oct;5(10):2861-4 PMID: 17022658 PMCID: PMC2814535 10/07/2006       45 Citations
  • Consomic strategies to localize genomic regions related to vascular reactivity in the Dahl salt-sensitive rat. (Kunert MP, Drenjancevic-Peric I, Dwinell MR, Lombard JH, Cowley AW Jr, Greene AS, Kwitek AE, Jacob HJ) Physiol Genomics 2006 Aug 16;26(3):218-25 PMID: 16772359 06/15/2006       20 Citations
  • Proteomics-based development of biomarkers in cardiovascular disease: mechanistic, clinical, and therapeutic insights. (Mayr M, Zhang J, Greene AS, Gutterman D, Perloff J, Ping P) Mol Cell Proteomics 2006 Oct;5(10):1853-64 PMID: 16733263 05/31/2006       71 Citations
  • BN phenome: detailed characterization of the cardiovascular, renal, and pulmonary systems of the sequenced rat. (Kwitek AE, Jacob HJ, Baker JE, Dwinell MR, Forster HV, Greene AS, Kunert MP, Lombard JH, Mattson DL, Pritchard KA Jr, Roman RJ, Tonellato PJ, Cowley AW Jr) Physiol Genomics 2006 Apr 13;25(2):303-13 PMID: 16478827 02/16/2006       26 Citations
  • Role of endothelial cell apoptosis in regulation of skeletal muscle angiogenesis during high and low salt intake. (de Resende MM, Amaral SL, Munzenmaier DH, Greene AS) Physiol Genomics 2006 Apr 13;25(2):325-35 PMID: 16464974 02/09/2006       12 Citations
  • Angiotensin II infusion restores stimulated angiogenesis in the skeletal muscle of rats on a high-salt diet. (Petersen MC, Munzenmaier DH, Greene AS) Am J Physiol Heart Circ Physiol 2006 Jul;291(1):H114-20 PMID: 16461372 02/08/2006       28 Citations
  • Localization of the renin-angiotensin system components to the skeletal muscle microcirculation. (Agoudemos MM, Greene AS) Microcirculation 2005 Dec;12(8):627-36 PMID: 16284004 11/15/2005       18 Citations
  • Chronic angiotensin II AT1 receptor blockade increases cerebral cortical microvessel density. (Munzenmaier DH, Greene AS) Am J Physiol Heart Circ Physiol 2006 Feb;290(2):H512-6 PMID: 16199473 10/04/2005       31 Citations
  • Computational modeling of physiological systems. (Beard DA, Bassingthwaighte JB, Greene AS) Physiol Genomics 2005 Sep 21;23(1):1-3; discussion 4 PMID: 16179418 09/24/2005       40 Citations
  • DeNovoID: a web-based tool for identifying peptides from sequence and mass tags deduced from de novo peptide sequencing by mass spectroscopy. (Halligan BD, Ruotti V, Twigger SN, Greene AS) Nucleic Acids Res 2005 Jul 01;33(Web Server issue):W376-81 PMID: 15980493 PMCID: PMC1160222 06/28/2005       13 Citations
  • Simultaneous quantification and identification using 18O labeling with an ion trap mass spectrometer and the analysis software application "ZoomQuant". (Hicks WA, Halligan BD, Slyper RY, Twigger SN, Greene AS, Olivier M) J Am Soc Mass Spectrom 2005 Jun;16(6):916-25 PMID: 15907706 PMCID: PMC2771642 05/24/2005       24 Citations
  • ZoomQuant: an application for the quantitation of stable isotope labeled peptides. (Halligan BD, Slyper RY, Twigger SN, Hicks W, Olivier M, Greene AS) J Am Soc Mass Spectrom 2005 Mar;16(3):302-6 PMID: 15734322 PMCID: PMC2793075 03/01/2005       60 Citations
  • Arteriolar responses to vasodilator stimuli and elevated P(O2) in renin congenic and Dahl salt-sensitive rats. (Drenjancevic-Peric I, Greene AS, Kunert MP, Lombard JH) Microcirculation 2004 Dec;11(8):669-77 PMID: 15726834 02/25/2005       14 Citations
  • Conversion of renin substrate tetradecapeptide to angiotensin II by rat MAB elastase-2. (Santos CF, Greene AS, Salgado MC, Oliveira EB) Can J Physiol Pharmacol 2004 Nov;82(11):1000-5 PMID: 15644940 01/13/2005       7 Citations
  • Identification of persistently altered gene expression in the kidney after functional recovery from ischemic acute renal failure. (Basile DP, Fredrich K, Alausa M, Vio CP, Liang M, Rieder MR, Greene AS, Cowley AW Jr) Am J Physiol Renal Physiol 2005 May;288(5):F953-63 PMID: 15632414 01/06/2005       75 Citations
  • Peptide identification using peptide amino acid attribute vectors. (Halligan BD, Dratz EA, Feng X, Twigger SN, Tonellato PJ, Greene AS) J Proteome Res 2004 Jul-Aug;3(4):813-20 PMID: 15359736 09/14/2004       4 Citations
  • Consomic rat model systems for physiological genomics. (Cowley AW Jr, Liang M, Roman RJ, Greene AS, Jacob HJ) Acta Physiol Scand 2004 Aug;181(4):585-92 PMID: 15283774 07/31/2004       95 Citations
  • Reverse transcription and polymerase chain reaction: principles and applications in dentistry. (Santos CF, Sakai VT, Machado MA, Schippers DN, Greene AS) J Appl Oral Sci 2004 Mar;12(1):1-11 PMID: 21365144 03/01/2004    
  • High throughput gene expression profiling: a molecular approach to integrative physiology. (Liang M, Cowley AW, Greene AS) J Physiol 2004 Jan 01;554(Pt 1):22-30 PMID: 14678487 PMCID: PMC1664740 12/18/2003       33 Citations
  • Influence of diet and genetics on hypertension and renal disease in Dahl salt-sensitive rats. (Mattson DL, Kunert MP, Kaldunski ML, Greene AS, Roman RJ, Jacob HJ, Cowley AW Jr) Physiol Genomics 2004 Jan 15;16(2):194-203 PMID: 14600213 11/06/2003       47 Citations
  • Genomic map of cardiovascular phenotypes of hypertension in female Dahl S rats. (Moreno C, Dumas P, Kaldunski ML, Tonellato PJ, Greene AS, Roman RJ, Cheng Q, Wang Z, Jacob HJ, Cowley AW Jr) Physiol Genomics 2003 Nov 11;15(3):243-57 PMID: 14532335 10/09/2003       79 Citations
  • Quantitative assessment of the importance of dye switching and biological replication in cDNA microarray studies. (Liang M, Briggs AG, Rute E, Greene AS, Cowley AW Jr) Physiol Genomics 2003 Aug 15;14(3):199-207 PMID: 12799473 06/12/2003       30 Citations
  • Functional role, cellular source, and tissue distribution of rat elastase-2, an angiotensin II-forming enzyme. (Santos CF, Caprio MA, Oliveira EB, Salgado MC, Schippers DN, Munzenmaier DH, Greene AS) Am J Physiol Heart Circ Physiol 2003 Aug;285(2):H775-83 PMID: 12714330 04/26/2003       26 Citations
  • Assessing unmodified 70-mer oligonucleotide probe performance on glass-slide microarrays. (Wang HY, Malek RL, Kwitek AE, Greene AS, Luu TV, Behbahani B, Frank B, Quackenbush J, Lee NH) Genome Biol 2003;4(1):R5 PMID: 12540297 PMCID: PMC151289 01/24/2003       118 Citations
  • CYP4A metabolites of arachidonic acid and VEGF are mediators of skeletal muscle angiogenesis. (Amaral SL, Maier KG, Schippers DN, Roman RJ, Greene AS) Am J Physiol Heart Circ Physiol 2003 May;284(5):H1528-35 PMID: 12521947 01/11/2003       71 Citations
  • Insights into Dahl salt-sensitive hypertension revealed by temporal patterns of renal medullary gene expression. (Liang M, Yuan B, Rute E, Greene AS, Olivier M, Cowley AW Jr) Physiol Genomics 2003 Feb 06;12(3):229-37 PMID: 12488510 12/19/2002       49 Citations
  • The CB1 receptor antagonist SR141716 enhances stimulus-induced activation of the primary somatosensory cortex of the rat. (Patel S, Gerrits R, Muthian S, Greene AS, Hillard CJ) Neurosci Lett 2002 Dec 25;335(2):95-8 PMID: 12459507 12/03/2002       12 Citations
  • Ca(2+)-activated potassium (K(Ca)) channel inhibition decreases neuronal activity-blood flow coupling. (Gerrits RJ, Stein EA, Greene AS) Brain Res 2002 Sep 06;948(1-2):108-16 PMID: 12383961 10/18/2002       11 Citations
  • Role of 20-hydroxyeicosatetraenoic acid in the renal and vasoconstrictor actions of angiotensin II. (Alonso-Galicia M, Maier KG, Greene AS, Cowley AW Jr, Roman RJ) Am J Physiol Regul Integr Comp Physiol 2002 Jul;283(1):R60-8 PMID: 12069931 06/19/2002       123 Citations
  • Molecular cloning and sequencing of the cDNA for rat mesenteric arterial bed elastase-2, an angiotensin II-forming enzyme. (Santos CF, Oliveira EB, Salgado MC, Greene AS) J Cardiovasc Pharmacol 2002 May;39(5):628-35 PMID: 11973405 04/26/2002       20 Citations
  • Mapping baroreceptor function to genome: a mathematical modeling approach. (Kendziorski CM, Cowley AW Jr, Greene AS, Salgado HC, Jacob HJ, Tonellato PJ) Genetics 2002 Apr;160(4):1687-95 PMID: 11973321 PMCID: PMC1462065 04/26/2002       10 Citations
  • Application of physiological genomics to the microcirculation. (Greene AS) Microcirculation 2002 Jan;9(1):3-12 PMID: 11896555 03/16/2002       8 Citations
  • Renal medullary genes in salt-sensitive hypertension: a chromosomal substitution and cDNA microarray study. (Liang M, Yuan B, Rute E, Greene AS, Zou AP, Soares P, MCQuestion GD, Slocum GR, Jacob HJ, Cowley AW Jr) Physiol Genomics 2002 Feb 28;8(2):139-49 PMID: 11875192 03/05/2002       42 Citations
  • Microvascular angiogenesis and the renin-angiotensin system. (Greene AS, Amaral SL) Curr Hypertens Rep 2002 Feb;4(1):56-62 PMID: 11790293 01/16/2002       27 Citations
  • Implications of circadian gene expression in kidney, liver and the effects of fasting on pharmacogenomic studies. (Kita Y, Shiozawa M, Jin W, Majewski RR, Besharse JC, Greene AS, Jacob HJ) Pharmacogenetics 2002 Jan;12(1):55-65 PMID: 11773865 01/05/2002       122 Citations
  • Functional cerebral hyperemia is unaffected by isovolemic hemodilution. (Shen H, Greene AS, Stein EA, Hudetz AG) Anesthesiology 2002 Jan;96(1):142-7 PMID: 11753014 12/26/2001    
  • A genomic-systems biology map for cardiovascular function. (Stoll M, Cowley AW Jr, Tonellato PJ, Greene AS, Kaldunski ML, Roman RJ, Dumas P, Schork NJ, Wang Z, Jacob HJ) Science 2001 Nov 23;294(5547):1723-6 PMID: 11721057 11/27/2001       146 Citations
  • MR-derived cerebral blood volume maps: issues regarding histological validation and assessment of tumor angiogenesis. (Pathak AP, Schmainda KM, Ward BD, Linderman JR, Rebro KJ, Greene AS) Magn Reson Med 2001 Oct;46(4):735-47 PMID: 11590650 10/09/2001       98 Citations
  • Distribution of angiotensin II receptor expression in the microcirculation of striated muscle. (Linderman JR, Greene AS) Microcirculation 2001 Aug;8(4):275-81 PMID: 11528535 08/31/2001       28 Citations
  • Angiotensin II and VEGF are involved in angiogenesis induced by short-term exercise training. (Amaral SL, Papanek PE, Greene AS) Am J Physiol Heart Circ Physiol 2001 Sep;281(3):H1163-9 PMID: 11514283 08/22/2001       112 Citations
  • Anesthesia alters NO-mediated functional hyperemia. (Gerrits RJ, Stein EA, Greene AS) Brain Res 2001 Jul 13;907(1-2):20-6 PMID: 11430881 06/30/2001       11 Citations
  • Angiogenesis induced by electrical stimulation is mediated by angiotensin II and VEGF. (Amaral SL, Linderman JR, Morse MM, Greene AS) Microcirculation 2001 Feb;8(1):57-67 PMID: 11296854 04/12/2001       94 Citations
  • Brown Norway chromosome 13 confers protection from high salt to consomic Dahl S rat. (Cowley AW Jr, Roman RJ, Kaldunski ML, Dumas P, Dickhout JG, Greene AS, Jacob HJ) Hypertension 2001 Feb;37(2 Pt 2):456-61 PMID: 11230318 03/07/2001       150 Citations
  • Renin gene transfer restores angiogenesis and vascular endothelial growth factor expression in Dahl S rats. (Amaral SL, Roman RJ, Greene AS) Hypertension 2001 Feb;37(2 Pt 2):386-90 PMID: 11230305 03/07/2001       46 Citations
  • Genetic dissection of honeybee (Apis mellifera L.) foraging behavior. (Page RE Jr, Fondrk MK, Hunt GJ, Guzmán-Novoa E, Humphries MA, Nguyen K, Greene AS) J Hered 2000 Nov-Dec;91(6):474-9 PMID: 11218085 02/24/2001       97 Citations
  • Measurement of vascular density. (Greene AS, Rieder MJ) Methods Mol Med 2001;51:489-96 PMID: 21331738 01/01/2001    
  • Microvascular flow and tissue PO(2) in skeletal muscle of chronic reduced renal mass hypertensive rats. (Lombard JH, Frisbee JC, Greene AS, Hudetz AG, Roman RJ, Tonellato PJ) Am J Physiol Heart Circ Physiol 2000 Nov;279(5):H2295-302 PMID: 11045965 10/25/2000       14 Citations
  • Genetically defined risk of salt sensitivity in an intercross of Brown Norway and Dahl S rats. (Cowley AW Jr, Stoll M, Greene AS, Kaldunski ML, Roman RJ, Tonellato PJ, Schork NJ, Dumas P, Jacob HJ) Physiol Genomics 2000 Apr 27;2(3):107-15 PMID: 11015589 10/04/2000       40 Citations
  • Quantification of the contribution of type 1 and type 2 angiotensin II receptors to the net tissue specific effect of angiotensin II. (Nora EH, Tonellato PJ, Greene AS) Ann Biomed Eng 2000 Jun;28(6):653-64 PMID: 10983711 09/13/2000       7 Citations
  • Development of an implantable muscle stimulator: measurement of stimulated angiogenesis and poststimulus vessel regression. (Linderman JR, Kloehn MR, Greene AS) Microcirculation 2000 Apr;7(2):119-28 PMID: 10802854 05/10/2000       35 Citations
  • Regional cerebral blood flow responses to variable frequency whisker stimulation: an autoradiographic analysis. (Gerrits RJ, Raczynski C, Greene AS, Stein EA) Brain Res 2000 May 12;864(2):205-12 PMID: 10802027 05/10/2000       38 Citations
  • The Microcirculation Physiome Project. (Popel AS, Greene AS, Ellis CG, Ley KF, Skalak TC, Tonellato PJ) Ann Biomed Eng 1998 Nov-Dec;26(6):911-3 PMID: 9846930 12/10/1998       16 Citations
  • Life and death in the microcirculation: a role for angiotensin II. (Greene AS) Microcirculation 1998;5(2-3):101-7 PMID: 9789251 10/28/1998       30 Citations
  • Laser-Doppler flowmetry utilizing a thinned skull cranial window preparation and automated stimulation. (Gerrits RJ, Stein EA, Greene AS) Brain Res Brain Res Protoc 1998 Sep;3(1):14-21 PMID: 9767083 10/10/1998       19 Citations
  • Localization of the ANG II type 2 receptor in the microcirculation of skeletal muscle. (Nora EH, Munzenmaier DH, Hansen-Smith FM, Lombard JH, Greene AS) Am J Physiol 1998 Oct;275(4 Pt 2):H1395-403 PMID: 9746490 09/24/1998       58 Citations
  • Gender-specific protection from microvessel rarefaction in female hypertensive rats. (Papanek PE, Rieder MJ, Lombard JH, Greene AS) Am J Hypertens 1998 Aug;11(8 Pt 1):998-1005 PMID: 9715794 08/26/1998       10 Citations
  • Blood flow increases linearly in rat somatosensory cortex with increased whisker movement frequency. (Gerrits RJ, Stein EA, Greene AS) Brain Res 1998 Feb 02;783(1):151-7 PMID: 9479064 05/02/1998       35 Citations
  • Documentation of angiotensin II receptors in glomerular epithelial cells. (Sharma M, Sharma R, Greene AS, McCarthy ET, Savin VJ) Am J Physiol 1998 Mar;274(3 Pt 2):F623-7 PMID: 9530280 04/08/1998       77 Citations
  • Reversal of microvascular rarefaction and reduced renal mass hypertension. (Rieder MJ, Roman RJ, Greene AS) Hypertension 1997 Jul;30(1 Pt 1):120-7 PMID: 9231831 07/01/1997       47 Citations
  • Suppression of angiotensin-converting enzyme expression and activity by shear stress. (Rieder MJ, Carmona R, Krieger JE, Pritchard KA Jr, Greene AS) Circ Res 1997 Mar;80(3):312-9 PMID: 9048650 03/01/1997       106 Citations
  • Rapid microvessel rarefaction with elevated salt intake and reduced renal mass hypertension in rats. (Hansen-Smith FM, Morris LW, Greene AS, Lombard JH) Circ Res 1996 Aug;79(2):324-30 PMID: 8756011 08/01/1996    
  • Mathematical analysis of type-I and type-IIb muscle fiber force generation in renal hypertension. (Rieder MJ, O'Drobinak DM, Tonellato PJ, Greene AS) Ann Biomed Eng 1996 Jul-Aug;24(4):489-99 PMID: 8841724 07/01/1996       1 Citations
  • Opposing actions of angiotensin II on microvascular growth and arterial blood pressure. (Munzenmaier DH, Greene AS) Hypertension 1996 Mar;27(3 Pt 2):760-5 PMID: 8613237 03/01/1996       244 Citations
  • Decreases in steady-state muscle performance and vessel density in reduced renal mass hypertensive rats. (O'Drobinak DM, Greene AS) Am J Physiol 1996 Feb;270(2 Pt 2):H661-7 PMID: 8779843 02/01/1996       12 Citations
  • Angiotensin II mediates a sustained rise in nuclear and cytoplasmic calcium via multiple receptor subtypes. (Munzenmaier DH, Greene AS) Am J Physiol 1995 Aug;269(2 Pt 2):H565-70 PMID: 7653620 08/01/1995       20 Citations
  • A computerized method for determination of microvascular density. (Rieder MJ, O'Drobinak DM, Greene AS) Microvasc Res 1995 Mar;49(2):180-9 PMID: 7603355 03/01/1995    
  • Hemodynamic and microcirculatory changes during development of renal hypertension. (Hernandez I, Greene AS) Am J Physiol 1995 Jan;268(1 Pt 2):H33-8 PMID: 7840279 01/01/1995       21 Citations
  • Hypertension induced by high salt intake in absence of volume retention in reduced renal mass rats. (Cowley AW Jr, Skelton MM, Papanek PE, Greene AS) Am J Physiol 1994 Nov;267(5 Pt 2):H1707-12 PMID: 7977802 11/11/1994       16 Citations
  • Hypoxia increases the activity of Ca(2+)-sensitive K+ channels in cat cerebral arterial muscle cell membranes. (Gebremedhin D, Bonnet P, Greene AS, England SK, Rusch NJ, Lombard JH, Harder DR) Pflugers Arch 1994 Oct;428(5-6):621-30 PMID: 7838685 10/01/1994       91 Citations
  • Imaging system for three-dimensional mapping of cerebrocortical capillary networks in vivo. (Hudetz AG, Greene AS, Fehér G, Knuese DE, Cowley AW Jr) Microvasc Res 1993 Nov;46(3):293-309 PMID: 8121315 11/01/1993    
  • Insulin does not reduce forearm alpha-vasoreactivity in obese hypertensive or lean normotensive men. (Neahring JM, Stepniakowski K, Greene AS, Egan BM) Hypertension 1993 Oct;22(4):584-90 PMID: 8406664 10/01/1993       36 Citations
  • Breathing periodicity in intact and carotid body-denervated ponies during normoxia and chronic hypoxia. (Brown DR, Forster HV, Greene AS, Lowry TF) J Appl Physiol (1985) 1993 Mar;74(3):1073-82 PMID: 8482645 03/01/1993       10 Citations
  • Salt intake and angiotensin II alter microvessel density in the cremaster muscle of normal rats. (Hernandez I, Cowley AW Jr, Lombard JH, Greene AS) Am J Physiol 1992 Sep;263(3 Pt 2):H664-7 PMID: 1415589 09/11/1992       71 Citations
  • Venous myogenic tone: studies in human and canine vessels. (Bérczi V, Greene AS, Dörnyei G, Csengödy J, Hódi G, Kádár A, Monos E) Am J Physiol 1992 Aug;263(2 Pt 2):H315-20 PMID: 1510127 08/01/1992       42 Citations
  • Effect of microvascular rarefaction on tissue oxygen delivery in hypertension. (Greene AS, Tonellato PJ, Zhang Z, Lombard JH, Cowley AW Jr) Am J Physiol 1992 May;262(5 Pt 2):H1486-93 PMID: 1590452 05/11/1992       43 Citations
  • Structural alterations of microvascular smooth muscle cells in reduced renal mass hypertension. (Hansen-Smith F, Greene AS, Cowley AW Jr, Lougee L, Lombard JH) Hypertension 1991 Jun;17(6 Pt 2):902-8 PMID: 2045171 06/01/1991       13 Citations
  • Regional autoregulatory responses during infusion of vasoconstrictor agents in conscious dogs. (Hellebrekers LJ, Liard JF, Laborde AL, Greene AS, Cowley AW Jr) Am J Physiol 1990 Oct;259(4 Pt 2):H1270-7 PMID: 2221130 10/11/1990       23 Citations
  • Structural changes during microvascular rarefaction in chronic hypertension. (Hansen-Smith F, Greene AS, Cowley AW Jr, Lombard JH) Hypertension 1990 Jun;15(6 Pt 2):922-8 PMID: 2351442 06/01/1990       65 Citations
  • Microvessel changes in hypertension measured by Griffonia simplicifolia I lectin. (Greene AS, Lombard JH, Cowley AW Jr, Hansen-Smith FM) Hypertension 1990 Jun;15(6 Pt 2):779-83 PMID: 2351431 06/01/1990       66 Citations
  • Role of blood volume expansion in Dahl rat model of hypertension. (Greene AS, Yu ZY, Roman RJ, Cowley AW Jr) Am J Physiol 1990 Feb;258(2 Pt 2):H508-14 PMID: 2309916 02/11/1990       94 Citations
  • Whole body autoregulation in conscious areflexic rats during hypoxia and hyperoxia. (Hinojosa-Laborde C, Greene AS, Cowley AW Jr) Am J Physiol 1989 Apr;256(4 Pt 2):H1023-9 PMID: 2705545 04/11/1989       8 Citations
  • Microvascular rarefaction and tissue vascular resistance in hypertension. (Greene AS, Tonellato PJ, Lui J, Lombard JH, Cowley AW Jr) Am J Physiol 1989 Jan;256(1 Pt 2):H126-31 PMID: 2912175 01/11/1989       197 Citations
  • Carotid sinus baroreceptor control of splanchnic resistance and capacity. (Brunner MJ, Greene AS, Frankle AE, Shoukas AA) Am J Physiol 1988 Dec;255(6 Pt 2):H1305-10 PMID: 3202194 12/01/1988       15 Citations
  • Concerning reflex summation. (Greene AS, Brunner MJ) Am J Physiol 1988 Nov;255(5 Pt 2):H1244-6 PMID: 3189583 11/01/1988       3 Citations
  • Autoregulation of the systemic circulation in conscious rats. (Hinojosa-Laborde C, Greene AS, Cowley AW Jr) Hypertension 1988 Jun;11(6 Pt 2):685-91 PMID: 3134305 06/01/1988       22 Citations
  • Aortic arch reflex control of total systemic vascular capacity. (Shoukas AA, Brunner MJ, Greene AS, MacAnespie CL) Am J Physiol 1987 Sep;253(3 Pt 2):H598-603 PMID: 3631297 09/01/1987       4 Citations
  • Measurement of peripheral blood flow by thermodilution techniques. (Nadel SN, Greene AS, White RI Jr, Anderson JH) Invest Radiol 1986 Aug;21(8):631-6 PMID: 3744738 08/01/1986    
  • Changes in canine cardiac function and venous return curves by the carotid baroreflex. (Greene AS, Shoukas AA) Am J Physiol 1986 Aug;251(2 Pt 2):H288-96 PMID: 3740285 08/01/1986       50 Citations
  • Interaction of right and left carotid sinus baroreflexes in the dog. (Greene AS, Brunner MJ, Shoukas AA) Am J Physiol 1986 Jan;250(1 Pt 2):H96-107 PMID: 3942243 01/01/1986       12 Citations
  • Interaction of canine carotid sinus and aortic arch baroreflexes in the control of total peripheral resistance. (Brunner MJ, Greene AS, Kallman CH, Shoukas AA) Circ Res 1984 Dec;55(6):740-50 PMID: 6499130 12/01/1984       14 Citations
  • Carotid sinus baroreceptor reflex control and the role of autoregulation in the systemic and pulmonary arterial pressure-flow relationships of the dog. (Shoukas AA, Brunner MJ, Frankle AE, Greene AS, Kallman CH) Circ Res 1984 Jun;54(6):674-82 PMID: 6733864 06/01/1984    
  • Determinants of systemic zero-flow arterial pressure. (Brunner MJ, Greene AS, Sagawa K, Shoukas AA) Am J Physiol 1983 Sep;245(3):H453-60 PMID: 6614193 09/01/1983       5 Citations
  • Carotid sinus baroreceptor reflex control of respiration. (Brunner MJ, Sussman MS, Greene AS, Kallman CH, Shoukas AA) Circ Res 1982 Nov;51(5):624-36 PMID: 7139881 11/01/1982    
  • Last update: 12/07/2018
    jenkins-FCD Prod-299 9ef562391eceb2b8f95265c767fbba1ce5a52fd6