Medical College of Wisconsin
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Ann K. Rosenthal MD

Ann K. Rosenthal MD

Vice Chairman, Chief, Professor

Institution: Medical College of Wisconsin
Department: Medicine
Division: Rheumatology
Program: Administration

Member of the Cardiovascular Center


  • Validation of administrative codes for calcium pyrophosphate deposition: a Veterans Administration study. (Bartels CM, Singh JA, Parperis K, Huber K, Rosenthal AK) J Clin Rheumatol 2015 Jun;21(4):189-92 PMID: 26010181 05/27/2015
  • Autophagy modulates articular cartilage vesicle formation in primary articular chondrocytes. (Rosenthal AK, Gohr CM, Mitton-Fitzgerald E, Grewal R, Ninomiya J, Coyne CB, Jackson WT) J Biol Chem 2015 May 22;290(21):13028-38 PMID: 25869133 PMCID: PMC4505557 04/15/2015
  • The adverse effects of diabetes on osteoarthritis: update on clinical evidence and molecular mechanisms. (King KB, Rosenthal AK) Osteoarthritis Cartilage 2015 Jun;23(6):841-50 PMID: 25837996 04/04/2015
  • Imaging of calcium pyrophosphate deposition disease. (Miksanek J, Rosenthal AK) Curr Rheumatol Rep 2015 Mar;17(3):20 PMID: 25761927 03/13/2015
  • Lysophosphatidic acid mediates fibrosis in injured joints by regulating collagen type I biosynthesis. (Wu L, Petrigliano FA, Ba K, Lee S, Bogdanov J, McAllister DR, Adams JS, Rosenthal AK, Van Handel B, Crooks GM, Lin Y, Evseenko D) Osteoarthritis Cartilage 2015 Feb;23(2):308-18 PMID: 25464168 PMCID: PMC4465392 12/03/2014
  • Clodronate exerts an anabolic effect on articular chondrocytes mediated through the purinergic receptor pathway. (Rosa RG, Collavino K, Lakhani A, Delve E, Weber JF, Rosenthal AK, Waldman SD) Osteoarthritis Cartilage 2014 Sep;22(9):1327-36 PMID: 25042551 07/22/2014
  • Nonpharmacologic and pharmacologic management of CPP crystal arthritis and BCP arthropathy and periarticular syndromes. (Rosenthal AK, Ryan LM) Rheum Dis Clin North Am 2014 May;40(2):343-56 PMID: 24703351 04/08/2014
  • Upregulation of ANK protein expression in joint tissue in calcium pyrophosphate dihydrate crystal deposition disease. (Uzuki M, Sawai T, Ryan LM, Rosenthal AK, Masuda I) J Rheumatol 2014 Jan;41(1):65-74 PMID: 24293574 12/03/2013
  • The progressive ankylosis gene product ANK regulates extracellular ATP levels in primary articular chondrocytes. (Rosenthal AK, Gohr CM, Mitton-Fitzgerald E, Lutz MK, Dubyak GR, Ryan LM) Arthritis Res Ther 2013;15(5):R154 PMID: 24286344 PMCID: PMC3978574 11/30/2013
  • Hyperglycemia reduces proteoglycan levels in tendons. (Burner T, Gohr C, Mitton-Fitzgerald E, Rosenthal AK) Connect Tissue Res 2012;53(6):535-41 PMID: 22891926 08/16/2012
  • Crystal arthritis: calcium pyrophosphate deposition-nothing 'pseudo' about it! (Rosenthal AK, Ryan LM) Nat Rev Rheumatol 2011 May;7(5):257-8 PMID: 21532639 05/03/2011
  • Proteomic analysis of articular cartilage vesicles from normal and osteoarthritic cartilage. (Rosenthal AK, Gohr CM, Ninomiya J, Wakim BT) Arthritis Rheum 2011 Feb;63(2):401-11 PMID: 21279997 PMCID: PMC3038242 02/01/2011
  • Crystals, inflammation, and osteoarthritis. (Rosenthal AK) Curr Opin Rheumatol 2011 Mar;23(2):170-3 PMID: 21169842 PMCID: PMC3154781 12/21/2010
  • Proteomic analysis of articular cartilage vesicles from normal and osteoarthritic cartilage. (Rosenthal AK, Gohr CM, Ninomiya J, Wakim BT) Arthritis Rheum 2010 Oct 27: PMID: 20981819 10/29/2010
  • Purine receptors modulate chondrocyte extracellular inorganic pyrophosphate production. (Rosenthal AK, Hempel D, Kurup IV, Masuda I, Ryan LM) Osteoarthritis Cartilage 2010 Nov;18(11):1496-501 PMID: 20709180 PMCID: PMC2975862 08/17/2010
  • Parallel regulation of extracellular ATP and inorganic pyrophosphate: roles of growth factors, transduction modulators, and ANK. (Costello JC, Rosenthal AK, Kurup IV, Masuda I, Medhora M, Ryan LM) Connect Tissue Res 2011 Apr;52(2):139-46 PMID: 20604715 07/08/2010
  • Type II collagen levels correlate with mineralization by articular cartilage vesicles. (Jubeck B, Muth E, Gohr CM, Rosenthal AK) Arthritis Rheum 2009 Sep;60(9):2741-6 PMID: 19714645 PMCID: PMC2749926 08/29/2009
  • Articular cartilage vesicles contain RNA. (Mitton E, Gohr CM, McNally MT, Rosenthal AK) Biochem Biophys Res Commun 2009 Oct 23;388(3):533-8 PMID: 19679100 PMCID: PMC2754773 08/15/2009
  • Dexamethasone promotes calcium pyrophosphate dihydrate crystal formation by articular chondrocytes. (Fahey M, Mitton E, Muth E, Rosenthal AK) J Rheumatol 2009 Jan;36(1):163-9 PMID: 19132782 PMCID: PMC2640436 01/10/2009
  • Calcium crystals and arthritis: what is new under polarizing light? (Rosenthal AK) J Clin Rheumatol 2009 Feb;15(1):42-5 PMID: 19131764 01/10/2009
  • Advanced glycation end products increase transglutaminase activity in primary porcine tenocytes. (Rosenthal AK, Gohr CM, Mitton E, Monnier V, Burner T) J Investig Med 2009 Feb;57(2):460-6 PMID: 19127169 01/08/2009
  • Diabetes and rheumatic diseases. (Burner TW, Rosenthal AK) Curr Opin Rheumatol 2009 Jan;21(1):50-4 PMID: 19077719 12/17/2008
  • Feasibility of a tetracycline-binding method for detecting synovial fluid basic calcium phosphate crystals. (Rosenthal AK, Fahey M, Gohr C, Burner T, Konon I, Daft L, Mattson E, Hirschmugl C, Ryan LM, Simkin P) Arthritis Rheum 2008 Oct;58(10):3270-4 PMID: 18821676 09/30/2008
  • Promotion of articular cartilage matrix vesicle mineralization by type I collagen. (Jubeck B, Gohr C, Fahey M, Muth E, Matthews M, Mattson E, Hirschmugl C, Rosenthal AK) Arthritis Rheum 2008 Sep;58(9):2809-17 PMID: 18759309 09/02/2008
  • Characterization of articular calcium-containing crystals by synchrotron FTIR. (Rosenthal AK, Mattson E, Gohr CM, Hirschmugl CJ) Osteoarthritis Cartilage 2008 Nov;16(11):1395-402 PMID: 18472285 PMCID: PMC2574906 05/13/2008
  • Association between crystals and cartilage degeneration in the ankle. (Muehleman C, Li J, Aigner T, Rappoport L, Mattson E, Hirschmugl C, Masuda K, Rosenthal AK) J Rheumatol 2008 Jun;35(6):1108-17 PMID: 18412302 04/17/2008
  • Calcific tendonitis : a model. (Gohr CM, Fahey M, Rosenthal AK) Connect Tissue Res 2007;48(6):286-91 PMID: 18075814 12/14/2007
  • Update in calcium deposition diseases. (Rosenthal AK) Curr Opin Rheumatol 2007 Mar;19(2):158-62 PMID: 17278931 02/07/2007
  • Osteopontin promotes pathologic mineralization in articular cartilage. (Rosenthal AK, Gohr CM, Uzuki M, Masuda I) Matrix Biol 2007 Mar;26(2):96-105 PMID: 17123806 PMCID: PMC1852442 11/25/2006
  • Calcium crystal deposition and osteoarthritis. (Rosenthal AK) Rheum Dis Clin North Am 2006 May;32(2):401-12, vii PMID: 16716886 05/24/2006
  • The serine protease inhibitor trappin-2 is present in cartilage and synovial fluid in osteoarthritis. (Jaovisidha K, Etim A, Yamakawa K, Masuda I, Gohr CM, Wakim BT, Boonapatcharoen N, Ninomiya J, Rosenthal AK) J Rheumatol 2006 Feb;33(2):318-25 PMID: 16465664 02/09/2006
  • Extracellular matrix changes regulate calcium crystal formation in articular cartilage. (Kalya S, Rosenthal AK) Curr Opin Rheumatol 2005 May;17(3):325-9 PMID: 15838245 04/20/2005
  • Transglutaminase contributes to CPPD crystal formation in osteoarthritis. (Heinkel D, Gohr CM, Uzuki M, Rosenthal AK) Front Biosci 2004 Sep 1;9:3257-61 PMID: 15353354 09/09/2004
  • Crystal arthropathies and other unpopular rheumatic diseases. (Rosenthal AK) Curr Opin Rheumatol 2004 May;16(3):262 PMID: 15103254 04/23/2004
  • Regulation of transglutaminase activity in articular chondrocytes through thrombin receptor-mediated factor XIII synthesis. (Rosenthal AK, Mosesson MW, Gohr CM, Masuda I, Heinkel D, Seibenlist KR) Thromb Haemost 2004 Mar;91(3):558-68 PMID: 14983233 02/26/2004
  • Thyroxine stimulates transglutaminase activity in articular chondrocytes. (Rosenthal AK, Heinkel D, Gohr CM) Osteoarthritis Cartilage 2003 Jun;11(6):463-70 PMID: 12801486 06/13/2003
  • Metabolism of extracellular pyrophosphate. (Ryan LM, Rosenthal AK) Curr Opin Rheumatol 2003 May;15(3):311-4 PMID: 12707586 04/23/2003
  • Calcium crystals in osteoarthritis. (Jaovisidha K, Rosenthal AK) Curr Opin Rheumatol 2002 May;14(3):298-302 PMID: 11981330 05/01/2002
  • Transglutaminase participates in the incorporation of latent TGFbeta into the extracellular matrix of aging articular chondrocytes. (Le M, Gohr CM, Rosenthal AK) Connect Tissue Res 2001;42(4):245-53 PMID: 11913769 03/27/2002
  • The high prevalence of pathologic calcium crystals in pre-operative knees. (Derfus BA, Kurian JB, Butler JJ, Daft LJ, Carrera GF, Ryan LM, Rosenthal AK) J Rheumatol 2002 Mar;29(3):570-4 PMID: 11908575 03/23/2002
  • The transglutaminase, Factor XIIIA, is present in articular chondrocytes. (Rosenthal AK, Masuda I, Gohr CM, Derfus BA, Le M) Osteoarthritis Cartilage 2001 Aug;9(6):578-81 PMID: 11520172 08/25/2001
  • Transforming growth factor beta-1 stimulates articular chondrocyte elaboration of matrix vesicles capable of greater calcium pyrophosphate precipitation. (Derfus BA, Camacho NP, Olmez U, Kushnaryov VM, Westfall PR, Ryan LM, Rosenthal AK) Osteoarthritis Cartilage 2001 Apr;9(3):189-94 PMID: 11300741 04/13/2001
  • Pathogenesis of calcium pyrophosphate crystal deposition disease. (Rosenthal AK) Curr Rheumatol Rep 2001 Feb;3(1):17-23 PMID: 11177767 03/20/2001
  • Identification of crystals in synovial fluids and joint tissues. (Rosenthal AK, Mandel N) Curr Rheumatol Rep 2001 Feb;3(1):11-6 PMID: 11177766 03/20/2001
  • Hepatic angiosarcoma occurring after cyclophosphamide therapy: case report and review of the literature. (Rosenthal AK, Klausmeier M, Cronin ME, McLaughlin JK) Am J Clin Oncol 2000 Dec;23(6):581-3 PMID: 11202801 02/24/2001
  • Participation of transglutaminase in the activation of latent transforming growth factor beta1 in aging articular cartilage. (Rosenthal AK, Gohr CM, Henry LA, Le M) Arthritis Rheum 2000 Aug;43(8):1729-33 PMID: 10943862 08/16/2000
  • Connective tissue disease and other related rheumatic conditions among patients with finger and hand and temporomandibular joint prostheses in Denmark. (Fryzek JP, Mellemkjaer L, Friis S, McLaughlin JK, Rosenthal AK, Blot WJ, Olsen JH) J Rheumatol 2000 Jun;27(6):1434-6 PMID: 10852266 06/14/2000
  • Formation of calcium pyrophosphate crystals: biologic implications. (Rosenthal AK) Curr Opin Rheumatol 2000 May;12(3):219-22 PMID: 10803752 05/10/2000
  • Thyroid hormones induce features of the hypertrophic phenotype and stimulate correlates of CPPD crystal formation in articular chondrocytes. (Rosenthal AK, Henry LA) J Rheumatol 1999 Feb;26(2):395-401 PMID: 9972975 02/11/1999
  • Calcium crystal-associated arthritides. (Rosenthal AK) Curr Opin Rheumatol 1998 May;10(3):273-7 PMID: 9608333 06/03/1998
  • Transglutaminase activity in aging articular chondrocytes and articular cartilage vesicles. (Rosenthal AK, Derfus BA, Henry LA) Arthritis Rheum 1997 May;40(5):966-70 PMID: 9153560 05/01/1997
  • Hemochromatosis-like arthropathy in diabetes mellitus without hemochromatosis. (McCarthy GM, Rosenthal AK, Carrera GF) J Rheumatol 1996 Aug;23(8):1453-6 PMID: 8856631 08/01/1996
  • Retinoic acid stimulates pyrophosphate elaboration by cartilage and chondrocytes. (Rosenthal AK, Henry LA) Calcif Tissue Int 1996 Aug;59(2):128-33 PMID: 8687982 08/01/1996
  • Incidence of cancer among patients with systemic sclerosis. (Rosenthal AK, McLaughlin JK, Gridley G, Nyrén O) Cancer 1995 Sep 1;76(5):910-4 PMID: 8625197 09/01/1995
  • Treatment of refractory crystal-associated arthritis. (Rosenthal AK, Ryan LM) Rheum Dis Clin North Am 1995 Feb;21(1):151-61 PMID: 7732165 02/01/1995
  • Insulin-like growth factor-1 suppresses pyrophosphate elaboration by transforming growth factor beta1-stimulated chondrocytes and cartilage. (Olmez U, Ryan LM, Kurup IV, Rosenthal AK) Osteoarthritis Cartilage 1994 Sep;2(3):149-54 PMID: 11550674 09/01/1994
  • Ageing increases growth factor-induced inorganic pyrophosphate elaboration by articular cartilage. (Rosenthal AK, Ryan LM) Mech Ageing Dev 1994 Jul;75(1):35-44 PMID: 9128752 07/01/1994
  • Probenecid inhibits transforming growth factor-beta 1 induced pyrophosphate elaboration by chondrocytes. (Rosenthal AK, Ryan LM) J Rheumatol 1994 May;21(5):896-900 PMID: 7520501 05/01/1994
  • Scleroderma and malignancy: an epidemiological study. (Rosenthal AK, McLaughlin JK, Linet MS, Persson I) Ann Rheum Dis 1993 Jul;52(7):531-3 PMID: 8346981 PMCID: PMC1005093 07/01/1993
  • A comparison of the effect of transforming growth factor beta 1 on pyrophosphate elaboration from various articular tissues. (Rosenthal AK, McCarty BA, Cheung HS, Ryan LM) Arthritis Rheum 1993 Apr;36(4):539-42 PMID: 7681284 04/01/1993
  • Transforming growth factor beta 1 stimulates inorganic pyrophosphate elaboration by porcine cartilage. (Rosenthal AK, Cheung HS, Ryan LM) Arthritis Rheum 1991 Jul;34(7):904-11 PMID: 1647773 07/01/1991
  • Diagnosis, pathogenesis, and management of reflex sympathetic dystrophy syndrome. (Rosenthal AK, Wortmann RL) Compr Ther 1991 Jun;17(6):46-50 PMID: 1934988 06/01/1991
  • Stimulation of pyrophosphate production in articular cartilage by a platelet-derived factor is independent of mitogenesis. (Rosenthal AK, Cheung HS, Ryan LM) J Lab Clin Med 1990 Mar;115(3):352-5 PMID: 2155981 03/01/1990
  • Stimulation of inorganic pyrophosphate elaboration by cultured cartilage and chondrocytes. (Ryan LM, Kurup I, Rosenthal AK, McCarty DJ) Arch Biochem Biophys 1989 Aug 1;272(2):393-9 PMID: 2546499 08/01/1989
  • Augmentation of inorganic pyrophosphate elaboration in cartilage by serum factors. (Rosenthal AK, Cheung HS, Ryan LM) Arch Biochem Biophys 1989 Aug 1;272(2):386-92 PMID: 2546498 08/01/1989
  • Lymphomatoid granulomatosis associated with a carotid sinus fistula: response to cytotoxic therapy. (Rosenthal AK, Rowe JM) Am J Med 1987 Aug;83(2):381-2 PMID: 3618648 08/01/1987
  • Pharmacological modification of immunoregulatory T lymphocytes . II. Modulation of T lymphocyte cell surface characteristics. (Birch RE, Rosenthal AK, Polmar SH) Clin Exp Immunol 1982 Apr;48(1):231-8 PMID: 6177462 PMCID: PMC1536581 04/01/1982
  • Last update: 08/24/2015