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Ann K. Rosenthal MD

Ann K. Rosenthal MD

Vice Chair, Chief, Professor

Institution: Medical College of Wisconsin
Department: Medicine
Division: Rheumatology
Program: Administration

Member of the Cardiovascular Center


  • Review: Unmet Needs and the Path Forward in Joint Disease Associated With Calcium Pyrophosphate Crystal Deposition. (Abhishek A, Neogi T, Choi H, Doherty M, Rosenthal AK, Terkeltaub R) Arthritis Rheumatol 2018 Aug;70(8):1182-1191 PMID: 29609209 PMCID: PMC6105380 04/03/2018    
  • Mutations in osteoprotegerin account for the CCAL1 locus in calcium pyrophosphate deposition disease. (Williams CJ, Qazi U, Bernstein M, Charniak A, Gohr C, Mitton-Fitzgerald E, Ortiz A, Cardinal L, Kaell AT, Rosenthal AK) Osteoarthritis Cartilage 2018 Jun;26(6):797-806 PMID: 29578045 PMCID: PMC6293976 03/27/2018       1 Citations
  • Concurrence of rheumatoid arthritis and calcium pyrophosphate deposition disease: A case collection and review of the literature. (Sabchyshyn V, Konon I, Ryan LM, Rosenthal AK) Semin Arthritis Rheum 2018 08;48(1):9-11 PMID: 29338885 PMCID: PMC6240440 01/18/2018    
  • Basic calcium phosphate crystal-associated musculoskeletal syndromes: an update. (Rosenthal AK) Curr Opin Rheumatol 2018 03;30(2):168-172 PMID: 29227355 PMCID: PMC6241512 12/12/2017       1 Citations
  • Calcium Pyrophosphate Deposition Disease and Associated Medical Comorbidities: A National Cross-Sectional Study of US Veterans. (Kleiber Balderrama C, Rosenthal AK, Lans D, Singh JA, Bartels CM) Arthritis Care Res (Hoboken) 2017 09;69(9):1400-1406 PMID: 27898996 PMCID: PMC5472491 11/30/2016       5 Citations
  • Erosive osteoarthritis: A systematic analysis of definitions used in the literature. (Gazeley DJ, Yeturi S, Patel PJ, Rosenthal AK) Semin Arthritis Rheum 2017 02;46(4):395-403 PMID: 27692966 PMCID: PMC6278834 10/04/2016       3 Citations
  • Pauci-Immune Crescentic Glomerulonephritis in Connective Tissue Disease. (Yeturi S, Cronin M, Robin A, Lorna C, Rosenthal AK) Case Rep Rheumatol 2016;2016:9070487 PMID: 27504208 PMCID: PMC4967670 08/10/2016    
  • Calcium Pyrophosphate Deposition Disease. (Rosenthal AK, Ryan LM) N Engl J Med 2016 Jun 30;374(26):2575-84 PMID: 27355536 PMCID: PMC6240444 06/30/2016       38 Citations
  • The Role of ANK in Calcium Pyrophosphate Deposition Disease. (Mitton-Fitzgerald E, Gohr CM, Bettendorf B, Rosenthal AK) Curr Rheumatol Rep 2016 May;18(5):25 PMID: 27032788 PMCID: PMC5453179 04/02/2016    
  • Editorial: Decreasing Crystal-Induced Consternation: New Methods of Crystal Identification. (Rosenthal AK, Pascual E) Arthritis Rheumatol 2016 07;68(7):1574-7 PMID: 26882418 02/18/2016       1 Citations
  • Articular cartilage vesicles and calcium crystal deposition diseases. (Rosenthal AK) Curr Opin Rheumatol 2016 Mar;28(2):127-32 PMID: 26814404 PMCID: PMC6240443 01/28/2016       6 Citations
  • Validation of administrative codes for calcium pyrophosphate deposition: a Veterans Administration study. (Bartels CM, Singh JA, Parperis K, Huber K, Rosenthal AK) J Clin Rheumatol 2015 Jun;21(4):189-92 PMID: 26010181 PMCID: PMC4694041 05/27/2015       6 Citations
  • Autophagy modulates articular cartilage vesicle formation in primary articular chondrocytes. (Rosenthal AK, Gohr CM, Mitton-Fitzgerald E, Grewal R, Ninomiya J, Coyne CB, Jackson WT) J Biol Chem 2015 May 22;290(21):13028-38 PMID: 25869133 PMCID: PMC4505557 04/15/2015       14 Citations
  • The adverse effects of diabetes on osteoarthritis: update on clinical evidence and molecular mechanisms. (King KB, Rosenthal AK) Osteoarthritis Cartilage 2015 Jun;23(6):841-50 PMID: 25837996 PMCID: PMC5530368 04/04/2015       36 Citations
  • Imaging of calcium pyrophosphate deposition disease. (Miksanek J, Rosenthal AK) Curr Rheumatol Rep 2015 Mar;17(3):20 PMID: 25761927 PMCID: PMC5471493 03/13/2015       11 Citations
  • Lysophosphatidic acid mediates fibrosis in injured joints by regulating collagen type I biosynthesis. (Wu L, Petrigliano FA, Ba K, Lee S, Bogdanov J, McAllister DR, Adams JS, Rosenthal AK, Van Handel B, Crooks GM, Lin Y, Evseenko D) Osteoarthritis Cartilage 2015 Feb;23(2):308-18 PMID: 25464168 PMCID: PMC4465392 12/03/2014       10 Citations
  • Clodronate exerts an anabolic effect on articular chondrocytes mediated through the purinergic receptor pathway. (Rosa RG, Collavino K, Lakhani A, Delve E, Weber JF, Rosenthal AK, Waldman SD) Osteoarthritis Cartilage 2014 Sep;22(9):1327-36 PMID: 25042551 PMCID: PMC5452978 07/22/2014       11 Citations
  • Nonpharmacologic and pharmacologic management of CPP crystal arthritis and BCP arthropathy and periarticular syndromes. (Rosenthal AK, Ryan LM) Rheum Dis Clin North Am 2014 May;40(2):343-56 PMID: 24703351 PMCID: PMC6240445 04/08/2014       5 Citations
  • Upregulation of ANK protein expression in joint tissue in calcium pyrophosphate dihydrate crystal deposition disease. (Uzuki M, Sawai T, Ryan LM, Rosenthal AK, Masuda I) J Rheumatol 2014 Jan;41(1):65-74 PMID: 24293574 PMCID: PMC6240442 12/03/2013       8 Citations
  • The progressive ankylosis gene product ANK regulates extracellular ATP levels in primary articular chondrocytes. (Rosenthal AK, Gohr CM, Mitton-Fitzgerald E, Lutz MK, Dubyak GR, Ryan LM) Arthritis Res Ther 2013 Oct 17;15(5):R154 PMID: 24286344 PMCID: PMC3978574 11/30/2013       20 Citations
  • Hyperglycemia reduces proteoglycan levels in tendons. (Burner T, Gohr C, Mitton-Fitzgerald E, Rosenthal AK) Connect Tissue Res 2012;53(6):535-41 PMID: 22891926 08/16/2012       24 Citations
  • Crystal arthritis: calcium pyrophosphate deposition-nothing 'pseudo' about it! (Rosenthal AK, Ryan LM) Nat Rev Rheumatol 2011 May;7(5):257-8 PMID: 21532639 05/03/2011       5 Citations
  • Proteomic analysis of articular cartilage vesicles from normal and osteoarthritic cartilage. (Rosenthal AK, Gohr CM, Ninomiya J, Wakim BT) Arthritis Rheum 2011 Feb;63(2):401-11 PMID: 21279997 PMCID: PMC3038242 02/01/2011       41 Citations
  • Crystals, inflammation, and osteoarthritis. (Rosenthal AK) Curr Opin Rheumatol 2011 Mar;23(2):170-3 PMID: 21169842 PMCID: PMC3154781 12/21/2010       49 Citations
  • Proteomic analysis of articular cartilage vesicles from normal and osteoarthritic cartilage. (Rosenthal AK, Gohr CM, Ninomiya J, Wakim BT) Arthritis Rheum 2010 Oct 27: PMID: 20981819 10/29/2010    
  • Purine receptors modulate chondrocyte extracellular inorganic pyrophosphate production. (Rosenthal AK, Hempel D, Kurup IV, Masuda I, Ryan LM) Osteoarthritis Cartilage 2010 Nov;18(11):1496-501 PMID: 20709180 PMCID: PMC2975862 08/17/2010       15 Citations
  • Parallel regulation of extracellular ATP and inorganic pyrophosphate: roles of growth factors, transduction modulators, and ANK. (Costello JC, Rosenthal AK, Kurup IV, Masuda I, Medhora M, Ryan LM) Connect Tissue Res 2011 Apr;52(2):139-46 PMID: 20604715 07/08/2010       34 Citations
  • Type II collagen levels correlate with mineralization by articular cartilage vesicles. (Jubeck B, Muth E, Gohr CM, Rosenthal AK) Arthritis Rheum 2009 Sep;60(9):2741-6 PMID: 19714645 PMCID: PMC2749926 08/29/2009       11 Citations
  • Articular cartilage vesicles contain RNA. (Mitton E, Gohr CM, McNally MT, Rosenthal AK) Biochem Biophys Res Commun 2009 Oct 23;388(3):533-8 PMID: 19679100 PMCID: PMC2754773 08/15/2009       12 Citations
  • Dexamethasone promotes calcium pyrophosphate dihydrate crystal formation by articular chondrocytes. (Fahey M, Mitton E, Muth E, Rosenthal AK) J Rheumatol 2009 Jan;36(1):163-9 PMID: 19132782 PMCID: PMC2640436 01/10/2009       10 Citations
  • Calcium crystals and arthritis: what is new under polarizing light? (Rosenthal AK) J Clin Rheumatol 2009 Feb;15(1):42-5 PMID: 19131764 01/10/2009       2 Citations
  • Advanced glycation end products increase transglutaminase activity in primary porcine tenocytes. (Rosenthal AK, Gohr CM, Mitton E, Monnier V, Burner T) J Investig Med 2009 Feb;57(2):460-6 PMID: 19127169 PMCID: PMC6240446 01/08/2009       13 Citations
  • Diabetes and rheumatic diseases. (Burner TW, Rosenthal AK) Curr Opin Rheumatol 2009 Jan;21(1):50-4 PMID: 19077719 12/17/2008       52 Citations
  • Feasibility of a tetracycline-binding method for detecting synovial fluid basic calcium phosphate crystals. (Rosenthal AK, Fahey M, Gohr C, Burner T, Konon I, Daft L, Mattson E, Hirschmugl C, Ryan LM, Simkin P) Arthritis Rheum 2008 Oct;58(10):3270-4 PMID: 18821676 PMCID: PMC2574625 09/30/2008       13 Citations
  • Promotion of articular cartilage matrix vesicle mineralization by type I collagen. (Jubeck B, Gohr C, Fahey M, Muth E, Matthews M, Mattson E, Hirschmugl C, Rosenthal AK) Arthritis Rheum 2008 Sep;58(9):2809-17 PMID: 18759309 PMCID: PMC6290924 09/02/2008       26 Citations
  • Characterization of articular calcium-containing crystals by synchrotron FTIR. (Rosenthal AK, Mattson E, Gohr CM, Hirschmugl CJ) Osteoarthritis Cartilage 2008 Nov;16(11):1395-402 PMID: 18472285 PMCID: PMC2574906 05/13/2008       23 Citations
  • Association between crystals and cartilage degeneration in the ankle. (Muehleman C, Li J, Aigner T, Rappoport L, Mattson E, Hirschmugl C, Masuda K, Rosenthal AK) J Rheumatol 2008 Jun;35(6):1108-17 PMID: 18412302 PMCID: PMC6240447 04/17/2008       42 Citations
  • Calcific tendonitis : a model. (Gohr CM, Fahey M, Rosenthal AK) Connect Tissue Res 2007;48(6):286-91 PMID: 18075814 12/14/2007       14 Citations
  • Update in calcium deposition diseases. (Rosenthal AK) Curr Opin Rheumatol 2007 Mar;19(2):158-62 PMID: 17278931 02/07/2007       48 Citations
  • Osteopontin promotes pathologic mineralization in articular cartilage. (Rosenthal AK, Gohr CM, Uzuki M, Masuda I) Matrix Biol 2007 Mar;26(2):96-105 PMID: 17123806 PMCID: PMC1852442 11/25/2006       47 Citations
  • Calcium crystal deposition and osteoarthritis. (Rosenthal AK) Rheum Dis Clin North Am 2006 May;32(2):401-12, vii PMID: 16716886 05/24/2006       35 Citations
  • The serine protease inhibitor trappin-2 is present in cartilage and synovial fluid in osteoarthritis. (Jaovisidha K, Etim A, Yamakawa K, Masuda I, Gohr CM, Wakim BT, Boonapatcharoen N, Ninomiya J, Rosenthal AK) J Rheumatol 2006 Feb;33(2):318-25 PMID: 16465664 02/09/2006       6 Citations
  • Extracellular matrix changes regulate calcium crystal formation in articular cartilage. (Kalya S, Rosenthal AK) Curr Opin Rheumatol 2005 May;17(3):325-9 PMID: 15838245 04/20/2005       23 Citations
  • Transglutaminase contributes to CPPD crystal formation in osteoarthritis. (Heinkel D, Gohr CM, Uzuki M, Rosenthal AK) Front Biosci 2004 Sep 01;9:3257-61 PMID: 15353354 09/09/2004       16 Citations
  • Crystal arthropathies and other unpopular rheumatic diseases. (Rosenthal AK) Curr Opin Rheumatol 2004 May;16(3):262 PMID: 15103254 04/23/2004       3 Citations
  • Regulation of transglutaminase activity in articular chondrocytes through thrombin receptor-mediated factor XIII synthesis. (Rosenthal AK, Mosesson MW, Gohr CM, Masuda I, Heinkel D, Seibenlist KR) Thromb Haemost 2004 Mar;91(3):558-68 PMID: 14983233 02/26/2004       10 Citations
  • Thyroxine stimulates transglutaminase activity in articular chondrocytes. (Rosenthal AK, Heinkel D, Gohr CM) Osteoarthritis Cartilage 2003 Jun;11(6):463-70 PMID: 12801486 06/13/2003       10 Citations
  • Metabolism of extracellular pyrophosphate. (Ryan LM, Rosenthal AK) Curr Opin Rheumatol 2003 May;15(3):311-4 PMID: 12707586 04/23/2003       21 Citations
  • Calcium crystals in osteoarthritis. (Jaovisidha K, Rosenthal AK) Curr Opin Rheumatol 2002 May;14(3):298-302 PMID: 11981330 05/01/2002       23 Citations
  • Transglutaminase participates in the incorporation of latent TGFbeta into the extracellular matrix of aging articular chondrocytes. (Le M, Gohr CM, Rosenthal AK) Connect Tissue Res 2001;42(4):245-53 PMID: 11913769 03/27/2002       15 Citations
  • The high prevalence of pathologic calcium crystals in pre-operative knees. (Derfus BA, Kurian JB, Butler JJ, Daft LJ, Carrera GF, Ryan LM, Rosenthal AK) J Rheumatol 2002 Mar;29(3):570-4 PMID: 11908575 03/23/2002       121 Citations
  • The transglutaminase, Factor XIIIA, is present in articular chondrocytes. (Rosenthal AK, Masuda I, Gohr CM, Derfus BA, Le M) Osteoarthritis Cartilage 2001 Aug;9(6):578-81 PMID: 11520172 08/25/2001       34 Citations
  • Transforming growth factor beta-1 stimulates articular chondrocyte elaboration of matrix vesicles capable of greater calcium pyrophosphate precipitation. (Derfus BA, Camacho NP, Olmez U, Kushnaryov VM, Westfall PR, Ryan LM, Rosenthal AK) Osteoarthritis Cartilage 2001 Apr;9(3):189-94 PMID: 11300741 04/13/2001       14 Citations
  • Pathogenesis of calcium pyrophosphate crystal deposition disease. (Rosenthal AK) Curr Rheumatol Rep 2001 Feb;3(1):17-23 PMID: 11177767 03/20/2001       12 Citations
  • Identification of crystals in synovial fluids and joint tissues. (Rosenthal AK, Mandel N) Curr Rheumatol Rep 2001 Feb;3(1):11-6 PMID: 11177766 03/20/2001       21 Citations
  • Hepatic angiosarcoma occurring after cyclophosphamide therapy: case report and review of the literature. (Rosenthal AK, Klausmeier M, Cronin ME, McLaughlin JK) Am J Clin Oncol 2000 Dec;23(6):581-3 PMID: 11202801 02/24/2001       11 Citations
  • Participation of transglutaminase in the activation of latent transforming growth factor beta1 in aging articular cartilage. (Rosenthal AK, Gohr CM, Henry LA, Le M) Arthritis Rheum 2000 Aug;43(8):1729-33 PMID: 10943862 08/16/2000       43 Citations
  • Connective tissue disease and other related rheumatic conditions among patients with finger and hand and temporomandibular joint prostheses in Denmark. (Fryzek JP, Mellemkjaer L, Friis S, McLaughlin JK, Rosenthal AK, Blot WJ, Olsen JH) J Rheumatol 2000 Jun;27(6):1434-6 PMID: 10852266 06/14/2000       1 Citations
  • Formation of calcium pyrophosphate crystals: biologic implications. (Rosenthal AK) Curr Opin Rheumatol 2000 May;12(3):219-22 PMID: 10803752 05/10/2000       8 Citations
  • Thyroid hormones induce features of the hypertrophic phenotype and stimulate correlates of CPPD crystal formation in articular chondrocytes. (Rosenthal AK, Henry LA) J Rheumatol 1999 Feb;26(2):395-401 PMID: 9972975 02/11/1999       34 Citations
  • Calcium crystal-associated arthritides. (Rosenthal AK) Curr Opin Rheumatol 1998 May;10(3):273-7 PMID: 9608333 06/03/1998       16 Citations
  • Transglutaminase activity in aging articular chondrocytes and articular cartilage vesicles. (Rosenthal AK, Derfus BA, Henry LA) Arthritis Rheum 1997 May;40(5):966-70 PMID: 9153560 05/01/1997       64 Citations
  • Hemochromatosis-like arthropathy in diabetes mellitus without hemochromatosis. (McCarthy GM, Rosenthal AK, Carrera GF) J Rheumatol 1996 Aug;23(8):1453-6 PMID: 8856631 08/01/1996       6 Citations
  • Retinoic acid stimulates pyrophosphate elaboration by cartilage and chondrocytes. (Rosenthal AK, Henry LA) Calcif Tissue Int 1996 Aug;59(2):128-33 PMID: 8687982 08/01/1996       14 Citations
  • Incidence of cancer among patients with systemic sclerosis. (Rosenthal AK, McLaughlin JK, Gridley G, Nyrén O) Cancer 1995 Sep 01;76(5):910-4 PMID: 8625197 09/01/1995       156 Citations
  • Treatment of refractory crystal-associated arthritis. (Rosenthal AK, Ryan LM) Rheum Dis Clin North Am 1995 Feb;21(1):151-61 PMID: 7732165 02/01/1995       33 Citations
  • Insulin-like growth factor-1 suppresses pyrophosphate elaboration by transforming growth factor beta1-stimulated chondrocytes and cartilage. (Olmez U, Ryan LM, Kurup IV, Rosenthal AK) Osteoarthritis Cartilage 1994 Sep;2(3):149-54 PMID: 11550674 09/01/1994       29 Citations
  • Ageing increases growth factor-induced inorganic pyrophosphate elaboration by articular cartilage. (Rosenthal AK, Ryan LM) Mech Ageing Dev 1994 Jul;75(1):35-44 PMID: 9128752 07/01/1994       21 Citations
  • Probenecid inhibits transforming growth factor-beta 1 induced pyrophosphate elaboration by chondrocytes. (Rosenthal AK, Ryan LM) J Rheumatol 1994 May;21(5):896-900 PMID: 7520501 05/01/1994       38 Citations
  • Scleroderma and malignancy: an epidemiological study. (Rosenthal AK, McLaughlin JK, Linet MS, Persson I) Ann Rheum Dis 1993 Jul;52(7):531-3 PMID: 8346981 PMCID: PMC1005093 07/01/1993       86 Citations
  • A comparison of the effect of transforming growth factor beta 1 on pyrophosphate elaboration from various articular tissues. (Rosenthal AK, McCarty BA, Cheung HS, Ryan LM) Arthritis Rheum 1993 Apr;36(4):539-42 PMID: 7681284 04/01/1993       31 Citations
  • Transforming growth factor beta 1 stimulates inorganic pyrophosphate elaboration by porcine cartilage. (Rosenthal AK, Cheung HS, Ryan LM) Arthritis Rheum 1991 Jul;34(7):904-11 PMID: 1647773 07/01/1991       61 Citations
  • Diagnosis, pathogenesis, and management of reflex sympathetic dystrophy syndrome. (Rosenthal AK, Wortmann RL) Compr Ther 1991 Jun;17(6):46-50 PMID: 1934988 06/01/1991       13 Citations
  • Stimulation of pyrophosphate production in articular cartilage by a platelet-derived factor is independent of mitogenesis. (Rosenthal AK, Cheung HS, Ryan LM) J Lab Clin Med 1990 Mar;115(3):352-5 PMID: 2155981 03/01/1990       2 Citations
  • Stimulation of inorganic pyrophosphate elaboration by cultured cartilage and chondrocytes. (Ryan LM, Kurup I, Rosenthal AK, McCarty DJ) Arch Biochem Biophys 1989 Aug 01;272(2):393-9 PMID: 2546499 08/01/1989       4 Citations
  • Augmentation of inorganic pyrophosphate elaboration in cartilage by serum factors. (Rosenthal AK, Cheung HS, Ryan LM) Arch Biochem Biophys 1989 Aug 01;272(2):386-92 PMID: 2546498 08/01/1989       4 Citations
  • Lymphomatoid granulomatosis associated with a carotid sinus fistula: response to cytotoxic therapy. (Rosenthal AK, Rowe JM) Am J Med 1987 Aug;83(2):381-2 PMID: 3618648 08/01/1987       1 Citations
  • Pharmacological modification of immunoregulatory T lymphocytes . II. Modulation of T lymphocyte cell surface characteristics. (Birch RE, Rosenthal AK, Polmar SH) Clin Exp Immunol 1982 Apr;48(1):231-8 PMID: 6177462 PMCID: PMC1536581 04/01/1982       38 Citations
  • Last update: 10/09/2018
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