Medical College of Wisconsin
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Ann K. Rosenthal MD

Ann K. Rosenthal MD

Vice Chairman, Chief, Professor

Institution: Medical College of Wisconsin
Department: Medicine
Division: Rheumatology
Program: Administration

Member of the Cardiovascular Center


  • Autophagy modulates articular cartilage vesicle formation in primary articular chondrocytes. (Rosenthal AK, Gohr CM, Mitton-Fitzgerald E, Grewal R, Ninomiya J, Coyne CB, Jackson WT) J Biol Chem 2015 May 22;290(21):13028-38 PMID 25869133
  • The adverse effects of diabetes on osteoarthritis: update on clinical evidence and molecular mechanisms. (King KB, Rosenthal AK) Osteoarthritis Cartilage 2015 Jun;23(6):841-850 PMID 25837996
  • Imaging of calcium pyrophosphate deposition disease. (Miksanek J, Rosenthal AK) Curr Rheumatol Rep 2015 Mar;17(3):20 PMID 25761927
  • Lysophosphatidic acid mediates fibrosis in injured joints by regulating collagen type I biosynthesis. (Wu L, Petrigliano FA, Ba K, Lee S, Bogdanov J, McAllister DR, Adams JS, Rosenthal AK, Van Handel B, Crooks GM, Lin Y, Evseenko D) Osteoarthritis Cartilage 2015 Feb;23(2):308-18 PMID 25464168
  • Clodronate exerts an anabolic effect on articular chondrocytes mediated through the purinergic receptor pathway. (Rosa RG, Collavino K, Lakhani A, Delve E, Weber JF, Rosenthal AK, Waldman SD) Osteoarthritis Cartilage 2014 Sep;22(9):1327-36 PMID 25042551
  • Nonpharmacologic and pharmacologic management of CPP crystal arthritis and BCP arthropathy and periarticular syndromes. (Rosenthal AK, Ryan LM) Rheum Dis Clin North Am 2014 May;40(2):343-56 PMID 24703351
  • Upregulation of ANK protein expression in joint tissue in calcium pyrophosphate dihydrate crystal deposition disease. (Uzuki M, Sawai T, Ryan LM, Rosenthal AK, Masuda I) J Rheumatol 2014 Jan;41(1):65-74 PMID 24293574
  • The progressive ankylosis gene product ANK regulates extracellular ATP levels in primary articular chondrocytes. (Rosenthal AK, Gohr CM, Mitton-Fitzgerald E, Lutz MK, Dubyak GR, Ryan LM) Arthritis Res Ther 2013;15(5):R154 PMID 24286344
  • Hyperglycemia reduces proteoglycan levels in tendons. (Burner T, Gohr C, Mitton-Fitzgerald E, Rosenthal AK) Connect Tissue Res 2012;53(6):535-41 PMID 22891926
  • Crystal arthritis: calcium pyrophosphate deposition-nothing 'pseudo' about it! (Rosenthal AK, Ryan LM) Nat Rev Rheumatol 2011 May;7(5):257-8 PMID 21532639
  • Proteomic analysis of articular cartilage vesicles from normal and osteoarthritic cartilage. (Rosenthal AK, Gohr CM, Ninomiya J, Wakim BT) Arthritis Rheum 2011 Feb;63(2):401-11 PMID 21279997
  • Crystals, inflammation, and osteoarthritis. (Rosenthal AK) Curr Opin Rheumatol 2011 Mar;23(2):170-3 PMID 21169842
  • Proteomic analysis of articular cartilage vesicles from normal and osteoarthritic cartilage. (Rosenthal AK, Gohr CM, Ninomiya J, Wakim BT) Arthritis Rheum 2010 Oct 27: PMID 20981819
  • Purine receptors modulate chondrocyte extracellular inorganic pyrophosphate production. (Rosenthal AK, Hempel D, Kurup IV, Masuda I, Ryan LM) Osteoarthritis Cartilage 2010 Nov;18(11):1496-501 PMID 20709180
  • Parallel regulation of extracellular ATP and inorganic pyrophosphate: roles of growth factors, transduction modulators, and ANK. (Costello JC, Rosenthal AK, Kurup IV, Masuda I, Medhora M, Ryan LM) Connect Tissue Res 2011 Apr;52(2):139-46 PMID 20604715
  • Type II collagen levels correlate with mineralization by articular cartilage vesicles. (Jubeck B, Muth E, Gohr CM, Rosenthal AK) Arthritis Rheum 2009 Sep;60(9):2741-6 PMID 19714645
  • Articular cartilage vesicles contain RNA. (Mitton E, Gohr CM, McNally MT, Rosenthal AK) Biochem Biophys Res Commun 2009 Oct 23;388(3):533-8 PMID 19679100
  • Dexamethasone promotes calcium pyrophosphate dihydrate crystal formation by articular chondrocytes. (Fahey M, Mitton E, Muth E, Rosenthal AK) J Rheumatol 2009 Jan;36(1):163-9 PMID 19132782
  • Calcium crystals and arthritis: what is new under polarizing light? (Rosenthal AK) J Clin Rheumatol 2009 Feb;15(1):42-5 PMID 19131764
  • Advanced glycation end products increase transglutaminase activity in primary porcine tenocytes. (Rosenthal AK, Gohr CM, Mitton E, Monnier V, Burner T) J Investig Med 2009 Feb;57(2):460-6 PMID 19127169
  • Diabetes and rheumatic diseases. (Burner TW, Rosenthal AK) Curr Opin Rheumatol 2009 Jan;21(1):50-4 PMID 19077719
  • Feasibility of a tetracycline-binding method for detecting synovial fluid basic calcium phosphate crystals. (Rosenthal AK, Fahey M, Gohr C, Burner T, Konon I, Daft L, Mattson E, Hirschmugl C, Ryan LM, Simkin P) Arthritis Rheum 2008 Oct;58(10):3270-4 PMID 18821676
  • Promotion of articular cartilage matrix vesicle mineralization by type I collagen. (Jubeck B, Gohr C, Fahey M, Muth E, Matthews M, Mattson E, Hirschmugl C, Rosenthal AK) Arthritis Rheum 2008 Sep;58(9):2809-17 PMID 18759309
  • Characterization of articular calcium-containing crystals by synchrotron FTIR. (Rosenthal AK, Mattson E, Gohr CM, Hirschmugl CJ) Osteoarthritis Cartilage 2008 Nov;16(11):1395-402 PMID 18472285
  • Association between crystals and cartilage degeneration in the ankle. (Muehleman C, Li J, Aigner T, Rappoport L, Mattson E, Hirschmugl C, Masuda K, Rosenthal AK) J Rheumatol 2008 Jun;35(6):1108-17 PMID 18412302
  • Calcific tendonitis : a model. (Gohr CM, Fahey M, Rosenthal AK) Connect Tissue Res 2007;48(6):286-91 PMID 18075814
  • Update in calcium deposition diseases. (Rosenthal AK) Curr Opin Rheumatol 2007 Mar;19(2):158-62 PMID 17278931
  • Osteopontin promotes pathologic mineralization in articular cartilage. (Rosenthal AK, Gohr CM, Uzuki M, Masuda I) Matrix Biol 2007 Mar;26(2):96-105 PMID 17123806
  • Calcium crystal deposition and osteoarthritis. (Rosenthal AK) Rheum Dis Clin North Am 2006 May;32(2):401-12, vii PMID 16716886
  • The serine protease inhibitor trappin-2 is present in cartilage and synovial fluid in osteoarthritis. (Jaovisidha K, Etim A, Yamakawa K, Masuda I, Gohr CM, Wakim BT, Boonapatcharoen N, Ninomiya J, Rosenthal AK) J Rheumatol 2006 Feb;33(2):318-25 PMID 16465664
  • Extracellular matrix changes regulate calcium crystal formation in articular cartilage. (Kalya S, Rosenthal AK) Curr Opin Rheumatol 2005 May;17(3):325-9 PMID 15838245
  • Transglutaminase contributes to CPPD crystal formation in osteoarthritis. (Heinkel D, Gohr CM, Uzuki M, Rosenthal AK) Front Biosci 2004 Sep 1;9:3257-61 PMID 15353354
  • Crystal arthropathies and other unpopular rheumatic diseases. (Rosenthal AK) Curr Opin Rheumatol 2004 May;16(3):262 PMID 15103254
  • Regulation of transglutaminase activity in articular chondrocytes through thrombin receptor-mediated factor XIII synthesis. (Rosenthal AK, Mosesson MW, Gohr CM, Masuda I, Heinkel D, Seibenlist KR) Thromb Haemost 2004 Mar;91(3):558-68 PMID 14983233
  • Thyroxine stimulates transglutaminase activity in articular chondrocytes. (Rosenthal AK, Heinkel D, Gohr CM) Osteoarthritis Cartilage 2003 Jun;11(6):463-70 PMID 12801486
  • Metabolism of extracellular pyrophosphate. (Ryan LM, Rosenthal AK) Curr Opin Rheumatol 2003 May;15(3):311-4 PMID 12707586
  • Calcium crystals in osteoarthritis. (Jaovisidha K, Rosenthal AK) Curr Opin Rheumatol 2002 May;14(3):298-302 PMID 11981330
  • Transglutaminase participates in the incorporation of latent TGFbeta into the extracellular matrix of aging articular chondrocytes. (Le M, Gohr CM, Rosenthal AK) Connect Tissue Res 2001;42(4):245-53 PMID 11913769
  • The high prevalence of pathologic calcium crystals in pre-operative knees. (Derfus BA, Kurian JB, Butler JJ, Daft LJ, Carrera GF, Ryan LM, Rosenthal AK) J Rheumatol 2002 Mar;29(3):570-4 PMID 11908575
  • The transglutaminase, Factor XIIIA, is present in articular chondrocytes. (Rosenthal AK, Masuda I, Gohr CM, Derfus BA, Le M) Osteoarthritis Cartilage 2001 Aug;9(6):578-81 PMID 11520172
  • Transforming growth factor beta-1 stimulates articular chondrocyte elaboration of matrix vesicles capable of greater calcium pyrophosphate precipitation. (Derfus BA, Camacho NP, Olmez U, Kushnaryov VM, Westfall PR, Ryan LM, Rosenthal AK) Osteoarthritis Cartilage 2001 Apr;9(3):189-94 PMID 11300741
  • Pathogenesis of calcium pyrophosphate crystal deposition disease. (Rosenthal AK) Curr Rheumatol Rep 2001 Feb;3(1):17-23 PMID 11177767
  • Identification of crystals in synovial fluids and joint tissues. (Rosenthal AK, Mandel N) Curr Rheumatol Rep 2001 Feb;3(1):11-6 PMID 11177766
  • Hepatic angiosarcoma occurring after cyclophosphamide therapy: case report and review of the literature. (Rosenthal AK, Klausmeier M, Cronin ME, McLaughlin JK) Am J Clin Oncol 2000 Dec;23(6):581-3 PMID 11202801
  • Participation of transglutaminase in the activation of latent transforming growth factor beta1 in aging articular cartilage. (Rosenthal AK, Gohr CM, Henry LA, Le M) Arthritis Rheum 2000 Aug;43(8):1729-33 PMID 10943862
  • Connective tissue disease and other related rheumatic conditions among patients with finger and hand and temporomandibular joint prostheses in Denmark. (Fryzek JP, Mellemkjaer L, Friis S, McLaughlin JK, Rosenthal AK, Blot WJ, Olsen JH) J Rheumatol 2000 Jun;27(6):1434-6 PMID 10852266
  • Formation of calcium pyrophosphate crystals: biologic implications. (Rosenthal AK) Curr Opin Rheumatol 2000 May;12(3):219-22 PMID 10803752
  • Thyroid hormones induce features of the hypertrophic phenotype and stimulate correlates of CPPD crystal formation in articular chondrocytes. (Rosenthal AK, Henry LA) J Rheumatol 1999 Feb;26(2):395-401 PMID 9972975
  • Calcium crystal-associated arthritides. (Rosenthal AK) Curr Opin Rheumatol 1998 May;10(3):273-7 PMID 9608333
  • Transglutaminase activity in aging articular chondrocytes and articular cartilage vesicles. (Rosenthal AK, Derfus BA, Henry LA) Arthritis Rheum 1997 May;40(5):966-70 PMID 9153560
  • Hemochromatosis-like arthropathy in diabetes mellitus without hemochromatosis. (McCarthy GM, Rosenthal AK, Carrera GF) J Rheumatol 1996 Aug;23(8):1453-6 PMID 8856631
  • Retinoic acid stimulates pyrophosphate elaboration by cartilage and chondrocytes. (Rosenthal AK, Henry LA) Calcif Tissue Int 1996 Aug;59(2):128-33 PMID 8687982
  • Incidence of cancer among patients with systemic sclerosis. (Rosenthal AK, McLaughlin JK, Gridley G, Nyrén O) Cancer 1995 Sep 1;76(5):910-4 PMID 8625197
  • Treatment of refractory crystal-associated arthritis. (Rosenthal AK, Ryan LM) Rheum Dis Clin North Am 1995 Feb;21(1):151-61 PMID 7732165
  • Insulin-like growth factor-1 suppresses pyrophosphate elaboration by transforming growth factor beta1-stimulated chondrocytes and cartilage. (Olmez U, Ryan LM, Kurup IV, Rosenthal AK) Osteoarthritis Cartilage 1994 Sep;2(3):149-54 PMID 11550674
  • Ageing increases growth factor-induced inorganic pyrophosphate elaboration by articular cartilage. (Rosenthal AK, Ryan LM) Mech Ageing Dev 1994 Jul;75(1):35-44 PMID 9128752
  • Probenecid inhibits transforming growth factor-beta 1 induced pyrophosphate elaboration by chondrocytes. (Rosenthal AK, Ryan LM) J Rheumatol 1994 May;21(5):896-900 PMID 7520501
  • Scleroderma and malignancy: an epidemiological study. (Rosenthal AK, McLaughlin JK, Linet MS, Persson I) Ann Rheum Dis 1993 Jul;52(7):531-3 PMID 8346981
  • A comparison of the effect of transforming growth factor beta 1 on pyrophosphate elaboration from various articular tissues. (Rosenthal AK, McCarty BA, Cheung HS, Ryan LM) Arthritis Rheum 1993 Apr;36(4):539-42 PMID 7681284
  • Transforming growth factor beta 1 stimulates inorganic pyrophosphate elaboration by porcine cartilage. (Rosenthal AK, Cheung HS, Ryan LM) Arthritis Rheum 1991 Jul;34(7):904-11 PMID 1647773
  • Diagnosis, pathogenesis, and management of reflex sympathetic dystrophy syndrome. (Rosenthal AK, Wortmann RL) Compr Ther 1991 Jun;17(6):46-50 PMID 1934988
  • Stimulation of pyrophosphate production in articular cartilage by a platelet-derived factor is independent of mitogenesis. (Rosenthal AK, Cheung HS, Ryan LM) J Lab Clin Med 1990 Mar;115(3):352-5 PMID 2155981
  • Stimulation of inorganic pyrophosphate elaboration by cultured cartilage and chondrocytes. (Ryan LM, Kurup I, Rosenthal AK, McCarty DJ) Arch Biochem Biophys 1989 Aug 1;272(2):393-9 PMID 2546499
  • Augmentation of inorganic pyrophosphate elaboration in cartilage by serum factors. (Rosenthal AK, Cheung HS, Ryan LM) Arch Biochem Biophys 1989 Aug 1;272(2):386-92 PMID 2546498
  • Lymphomatoid granulomatosis associated with a carotid sinus fistula: response to cytotoxic therapy. (Rosenthal AK, Rowe JM) Am J Med 1987 Aug;83(2):381-2 PMID 3618648
  • Pharmacological modification of immunoregulatory T lymphocytes . II. Modulation of T lymphocyte cell surface characteristics. (Birch RE, Rosenthal AK, Polmar SH) Clin Exp Immunol 1982 Apr;48(1):231-8 PMID 6177462
  • Last update: 05/26/2015