Medical College of Wisconsin
CTSICores SearchResearch InformaticsREDCap

Anna H. Huppler MD

Anna H. Huppler MD profile photo picture

Associate Professor

Institution: Medical College of Wisconsin
Department: Pediatrics
Division: Infectious Disease

Member of the Center for Immunology

View Curriculum Vitae

Research Experience

  • Candida albicans
  • Candidiasis
  • Candidiasis, Oral
  • Chemokines, CC
  • Chemokines, CXC
  • Neutrophils
  • immunology

    • Clinical Expertise

  • Immunocompromised Host
  • Infectious Disease Medicine
  • Invasive Fungal Infections
  • Mycoses
  • Pediatrics

    • Methodologies and Techniques

  • Cell Culture Techniques
  • Cloning, Molecular
  • Enzyme-Linked Immunosorbent Assay
  • Flow Cytometry
  • Models, Animal
  • Polymerase Chain Reaction
  • Reverse Transcriptase Polymerase Chain Reaction

    • Educational Expertise

  • Bacteria
  • Bacterial Infections and Mycoses
  • Fungi
  • Immune System Diseases
  • Parasitic Diseases
  • Virus Diseases
  • Viruses

  • Publications (43)

  • Pipeline of Novel Antifungals for Invasive Fungal Disease in Transplant Recipients: A Pediatric Perspective. (Hsu AJ, Hanisch BR, Fisher BT, Huppler AR) J Pediatric Infect Dis Soc 2024 Feb 28;13(Supplement_1):S68-S79 PMID: 38417087 SCOPUS ID: 2-s2.0-85186459019 02/28/2024    
  • Safety and Immunogenicity of Live Viral Vaccines in a Multicenter Cohort of Pediatric Transplant Recipients. (Feldman AG, Beaty BL, Ferrolino JA, Maron G, Weidner HK, Ali SA, Bitterfeld L, Boulware MA, Campbell KM, Carr E, Chapman S, Chang YC, Cunningham R, Dallas RH, Dantuluri KL, Domenick BN, Ebel NH, Elisofon S, Fawaz R, Foca M, Gans HA, Gopalareddy VV, Gu C, Gupta NA, Harmann K, Hollenbeck J, Huppler AR, Jaramillo C, Kasi N, Kerkar N, Lerret S, Lobritto SJ, Lopez MJ, Marini E, Mavis A, Mehra S, Moats L, Mohandas S, Munoz FM, Mysore KR, Onsan C, Ovchinsky N, Perkins K, Postma S, Pratscher L, Rand EB, Rowe RK, Schultz D, Sear K, Sell ML, Sharma T, Stoll J, Vang M, Villarin D, Weaver C, Wood P, Woodford-Berry O, Yanni G, Danziger-Isakov LA) JAMA Netw Open 2023 Oct 02;6(10):e2337602 PMID: 37824141 PMCID: PMC10570873 SCOPUS ID: 2-s2.0-85174751429 10/12/2023       3 Citations
  • Adjunctive Diagnostic Studies Completed Following Detection of Candidemia in Children: Secondary Analysis of Observed Practice From a Multicenter Cohort Study Conducted by the Pediatric Fungal Network. (Wattier RL, Bucayu RFT, Boge CLK, Ross RK, Yildirim I, Zaoutis TE, Palazzi DL, Vora SB, Castagnola E, Avilés-Robles M, Danziger-Isakov L, Tribble AC, Sharma TS, Arrieta AC, Maron G, Berman DM, Yin DE, Sung L, Green M, Roilides E, Belani K, Romero J, Soler-Palacin P, López-Medina E, Nolt D, Bin Hussain IZ, Muller WJ, Hauger SB, Halasa N, Dulek D, Pong A, Gonzalez BE, Abzug MJ, Carlesse F, Huppler AR, Rajan S, Aftandilian C, Ardura MI, Chakrabarti A, Hanisch B, Salvatore CM, Klingspor L, Knackstedt ED, Lutsar I, Santolaya ME, Shuster S, Johnson SK, Steinbach WJ, Fisher BT) J Pediatric Infect Dis Soc 2023 Sep 27;12(9):487-495 PMID: 37589394 PMCID: PMC10533205 SCOPUS ID: 2-s2.0-85172740128 08/17/2023       1 Citation
  • Use of Clinical Practice Guideline to Improve Management of Osteoarticular Infections in Children. (Dimo J, Hahn D, Schlidt K, Mobayed N, Dasgupta M, Barbeau J, Simpson PM, Soung P, Huppler AR) Hosp Pediatr 2023 Jul 01;13(7):579-591 PMID: 37313644 SCOPUS ID: 2-s2.0-85166746050 06/14/2023       1 Citation
  • Higher Weight-Based Doses Are Required to Achieve and Maintain Therapeutic Voriconazole Serum Trough Concentrations in Children. (Zembles TN, Dasgupta M, Kenkel TJ, Lehrer B, Simpson P, Havens PL, Huppler AR) J Pediatr Pharmacol Ther 2023;28(3):247-254 PMID: 37303767 PMCID: PMC10249970 SCOPUS ID: 2-s2.0-85161814249 06/12/2023    
  • Correction to: Multicenter Prospective Study of Biomarkers for Diagnosis of Invasive Candidiasis in Children and Adolescents. Clin Infect Dis 2023 Mar 04;76(5):972 PMID: 36790892 PMCID: PMC11015314 SCOPUS ID: 2-s2.0-85150000276 02/16/2023    
  • Review: Levofloxacin Prophylaxis in Pediatric Oncology Patients (Scheuermann A, Huppler AR, Mitchell M, Green JS) Current Treatment Options in Pediatrics September 2022;8(3):211-231 SCOPUS ID: 2-s2.0-85133189538 09/01/2022    
  • Antibiotic use in children with multisystem inflammatory syndrome associated with SARS-CoV-2. (Zembles TN, Ray KM, Kuhn EM, Huppler AR) Acta Paediatr 2022 Aug;111(8):1583-1584 PMID: 35599606 PMCID: PMC9347434 SCOPUS ID: 2-s2.0-85131542689 05/24/2022    
  • COVID-19 Pandemic Exacerbates Childhood Immunization Disparities. (Lehrer BJ, Lawton L, Kastens A, Malmstadt L, Rohloff R, Havens PL, Huppler AR) WMJ 2022 Apr;121(1):58-60 PMID: 35442581 SCOPUS ID: 2-s2.0-85128797680 04/21/2022       2 Citations
  • Multicenter Prospective Study of Biomarkers for Diagnosis of Invasive Candidiasis in Children and Adolescents. (Fisher BT, Boge CLK, Xiao R, Shuster S, Chin-Quee D, Allen J, Shaheen S, Hayden R, Suganda S, Zaoutis TE, Chang YC, Yin DE, Huppler AR, Danziger-Isakov L, Muller WJ, Roilides E, Romero J, Sue PK, Berman D, Wattier RL, Halasa N, Pong A, Maron G, Soler-Palacin P, Hutto SC, Gonzalez BE, Salvatore CM, Rajan S, Green M, Doby Knackstedt E, Hauger SB, Steinbach WJ) Clin Infect Dis 2022 Aug 25;75(2):248-259 PMID: 35134165 PMCID: PMC9890499 SCOPUS ID: 2-s2.0-85132121704 02/09/2022       8 Citations
  • Comparative Effectiveness of Echinocandins vs Triazoles or Amphotericin B Formulations as Initial Directed Therapy for Invasive Candidiasis in Children and Adolescents. (Fisher BT, Zaoutis TE, Xiao R, Wattier RL, Castagnola E, Pana ZD, Fullenkamp A, Boge CLK, Ross RK, Yildirim I, Palazzi DL, Danziger-Isakov L, Vora SB, Arrieta A, Yin DE, Avilés-Robles M, Sharma T, Tribble AC, Maron G, Berman D, Green M, Sung L, Romero J, Hauger SB, Roilides E, Belani K, Nolt D, Soler-Palacin P, López-Medina E, Muller WJ, Halasa N, Dulek D, Hussain IZB, Pong A, Hoffman J, Rajan S, Gonzalez BE, Hanisch B, Aftandilian C, Carlesse F, Abzug MJ, Huppler AR, Salvatore CM, Ardura MI, Chakrabarti A, Santolaya ME, Localio AR, Steinbach WJ) J Pediatric Infect Dis Soc 2021 Aug 10 PMID: 34374424 08/11/2021    
  • Metamorphic Protein Folding Encodes Multiple Anti-Candida Mechanisms in XCL1. (Dishman AF, He J, Volkman BF, Huppler AR) Pathogens 2021 Jun 17;10(6) PMID: 34204234 PMCID: PMC8235156 SCOPUS ID: 2-s2.0-85108986032 07/03/2021       2 Citations
  • Quality improvement project to improve vaccinations in the pediatric liver transplant population. (Gumm AJ, Lerret S, Zeman M, Rueter J, Huppler AR, Khan Z, Telega G, Vitola B) Pediatr Transplant 2021 Nov;25(7):e14076 PMID: 34185930 SCOPUS ID: 2-s2.0-85108843693 06/30/2021       3 Citations
  • Blastomycosis in 64 Wisconsin Children: Unanticipated Infection Risk and Severity in Urban Residents. (Hall JM, Havens PL, Mitchell EA, De Vela GN, Titus LL, Dasgupta M, Simpson PM, Kehl SC, Willoughby RE, Henrickson KJ, Mitchell ML, Huppler AR, Chusid MJ) Pediatr Infect Dis J 2021 Sep 01;40(9):802-807 PMID: 33990518 SCOPUS ID: 2-s2.0-85112752993 05/16/2021       1 Citation
  • Gammaherpesvirus Usurps Host IL-17 Signaling To Support the Establishment of Chronic Infection. (Jondle CN, Johnson KE, Aurubin C, Sylvester P, Xin G, Cui W, Huppler AR, Tarakanova VL) mBio 2021 Apr 06;12(2) PMID: 33824206 PMCID: PMC8092251 SCOPUS ID: 2-s2.0-85103513895 04/08/2021       8 Citations
  • Chemokine CCL28 Is a Potent Therapeutic Agent for Oropharyngeal Candidiasis. (He J, Thomas MA, de Anda J, Lee MW, Van Why E, Simpson P, Wong GCL, Grayson MH, Volkman BF, Huppler AR) Antimicrob Agents Chemother 2020 Jul 22;64(8) PMID: 32423961 PMCID: PMC7526824 SCOPUS ID: 2-s2.0-85088608725 05/20/2020       8 Citations
  • Switchable Membrane Remodeling and Antifungal Defense by Metamorphic Chemokine XCL1. (Dishman AF, Lee MW, de Anda J, Lee EY, He J, Huppler AR, Wong GCL, Volkman BF) ACS Infect Dis 2020 May 08;6(5):1204-1213 PMID: 32243126 PMCID: PMC7258946 SCOPUS ID: 2-s2.0-85084720920 04/04/2020       6 Citations
  • Erratum to: Attenuation of Helper T Cell Capacity for TH1 and TH17 Differentiation in Children With Nontuberculous Mycobacterial Infection. (Claeys TA, Rosas Mejia O, Marshall S, Jarzembowski JA, Hayes D, Hull NM, Liyanage NPM, Chun RH, Sulman CG, Huppler AR, Robinson RT) J Infect Dis 2020 May 11;221(11):1917 PMID: 31904837 PMCID: PMC8494011 SCOPUS ID: 2-s2.0-85084695497 01/07/2020    
  • The Interleukin (IL) 17R/IL-22R Signaling Axis Is Dispensable for Vulvovaginal Candidiasis Regardless of Estrogen Status. (Peters BM, Coleman BM, Willems HME, Barker KS, Aggor FEY, Cipolla E, Verma AH, Bishu S, Huppler AH, Bruno VM, Gaffen SL) J Infect Dis 2020 Apr 07;221(9):1554-1563 PMID: 31805183 PMCID: PMC7137889 SCOPUS ID: 2-s2.0-85078761600 12/06/2019       35 Citations
  • Attenuation of Helper T Cell Capacity for TH1 and TH17 Differentiation in Children With Nontuberculous Mycobacterial Infection. (Claeys TA, Rosas Mejia O, Marshall S, Jarzembowski JA, Hayes D Jr, Hull NM, Liyanage NPM, Chun RH, Sulman CG, Huppler AR, Robinson RT) J Infect Dis 2019 Oct 22;220(11):1843-1847 PMID: 31332447 PMCID: PMC7325325 SCOPUS ID: 2-s2.0-85073665266 07/25/2019       4 Citations
  • Pediatric Deep Neck Space Infections: A Medical and Surgical Perspective (Mohandas S, Gregory S, Chun RH, Huppler AR) Journal of Pediatric Infectious Diseases 2019;14(2):43-51 SCOPUS ID: 2-s2.0-85049857631 01/01/2019       1 Citation
  • The Solution Structure of CCL28 Reveals Structural Lability that Does Not Constrain Antifungal Activity. (Thomas MA, He J, Peterson FC, Huppler AR, Volkman BF) J Mol Biol 2018 Sep 14;430(18 Pt B):3266-3282 PMID: 29913161 PMCID: PMC6103841 SCOPUS ID: 2-s2.0-85049041059 06/19/2018       12 Citations
  • Development and implementation of an antimicrobial lock therapy guideline in a pediatric hospital. (Zembles TN, Flannery LS, Huppler AR) Am J Health Syst Pharm 2018 Mar 01;75(5):299-303 PMID: 29472511 SCOPUS ID: 2-s2.0-85042408173 02/24/2018       5 Citations
  • Oral epithelial cells orchestrate innate type 17 responses to Candida albicans through the virulence factor candidalysin. (Verma AH, Richardson JP, Zhou C, Coleman BM, Moyes DL, Ho J, Huppler AR, Ramani K, McGeachy MJ, Mufazalov IA, Waisman A, Kane LP, Biswas PS, Hube B, Naglik JR, Gaffen SL) Sci Immunol 2017 Nov 03;2(17) PMID: 29101209 PMCID: PMC5881387 SCOPUS ID: 2-s2.0-85034226532 11/05/2017       143 Citations
  • Successful Treatment of Invasive Conidiobolus Infection During Therapy for Acute Lymphoblastic Leukemia. (Erker C, Huppler AR, Walsh TJ, McCormick ME, Suchi M, Bhatt NS, Kehl SC, Southwood J, Harker-Murray P) J Pediatr Hematol Oncol 2018 Oct;40(7):e446-e449 PMID: 28991126 PMCID: PMC5904005 SCOPUS ID: 2-s2.0-85031495362 10/11/2017       8 Citations
  • Role of Molecular Biomarkers in the Diagnosis of Invasive Fungal Diseases in Children. (Huppler AR, Fisher BT, Lehrnbecher T, Walsh TJ, Steinbach WJ) J Pediatric Infect Dis Soc 2017 Sep 01;6(suppl_1):S32-S44 PMID: 28927202 PMCID: PMC5907877 SCOPUS ID: 2-s2.0-85045043737 09/21/2017       62 Citations
  • The Goldilocks model of immune symbiosis with Mycobacteria and Candida colonizers. (Robinson RT, Huppler AR) Cytokine 2017 Sep;97:49-65 PMID: 28570933 PMCID: PMC5765749 SCOPUS ID: 2-s2.0-85019740661 06/02/2017       14 Citations
  • Editorial: Fake it 'til you make it: mast cells acquire IL-17 exogenously. (Huppler AR, Gaffen SL) J Leukoc Biol 2016 Sep;100(3):445-6 PMID: 27587375 SCOPUS ID: 2-s2.0-84984998133 09/03/2016       2 Citations
  • An Optimized Voriconazole Dosing Strategy to Achieve Therapeutic Serum Concentrations in Children Younger than 2 Years Old. (Zembles TN, Thompson NE, Havens PL, Kaufman BA, Huppler AR) Pharmacotherapy 2016 Oct;36(10):1102-1108 PMID: 27548272 SCOPUS ID: 2-s2.0-84990831275 08/23/2016       17 Citations
  • Neutrophils Do Not Express IL-17A in the Context of Acute Oropharyngeal Candidiasis. (Huppler AR, Verma AH, Conti HR, Gaffen SL) Pathogens 2015 Jul 24;4(3):559-72 PMID: 26213975 PMCID: PMC4584272 SCOPUS ID: 2-s2.0-84985017808 07/28/2015       24 Citations
  • A Candida albicans Strain Expressing Mammalian Interleukin-17A Results in Early Control of Fungal Growth during Disseminated Infection. (Huppler AR, Whibley N, Woolford CA, Childs EE, He J, Biswas PS, McGeachy MJ, Mitchell AP, Gaffen SL) Infect Immun 2015 Sep;83(9):3684-92 PMID: 26150537 PMCID: PMC4534662 SCOPUS ID: 2-s2.0-84939513442 07/08/2015       4 Citations
  • Correction: Role of Neutrophils in IL-17-Dependent Immunity to Mucosal Candidiasis. (Huppler AR, Conti HR, Hernández-Santos N, Darville T, Biswas PS, Gaffen SL) J Immunol 2015 Feb 01;194(3):1382 PMID: 25596301 SCOPUS ID: 2-s2.0-84921509578 01/18/2015       2 Citations
  • Oral-resident natural Th17 cells and γδ T cells control opportunistic Candida albicans infections. (Conti HR, Peterson AC, Brane L, Huppler AR, Hernández-Santos N, Whibley N, Garg AV, Simpson-Abelson MR, Gibson GA, Mamo AJ, Osborne LC, Bishu S, Ghilardi N, Siebenlist U, Watkins SC, Artis D, McGeachy MJ, Gaffen SL) J Exp Med 2014 Sep 22;211(10):2075-84 PMID: 25200028 PMCID: PMC4172215 SCOPUS ID: 2-s2.0-84907202739 09/10/2014       204 Citations
  • An essential role of interleukin-17 receptor signaling in the development of autoimmune glomerulonephritis. (Ramani K, Pawaria S, Maers K, Huppler AR, Gaffen SL, Biswas PS) J Leukoc Biol 2014 Sep;96(3):463-72 PMID: 24935958 PMCID: PMC4138200 SCOPUS ID: 2-s2.0-84907329820 06/18/2014       37 Citations
  • Animal models for candidiasis. (Conti HR, Huppler AR, Whibley N, Gaffen SL) Curr Protoc Immunol 2014 Apr 02;105:19.6.1-19.6.17 PMID: 24700323 PMCID: PMC4088949 SCOPUS ID: 2-s2.0-84922696733 04/05/2014       93 Citations
  • Role of neutrophils in IL-17-dependent immunity to mucosal candidiasis. (Huppler AR, Conti HR, Hernández-Santos N, Darville T, Biswas PS, Gaffen SL) J Immunol 2014 Feb 15;192(4):1745-52 PMID: 24442441 PMCID: PMC3946223 SCOPUS ID: 2-s2.0-84894270649 01/21/2014       100 Citations
  • The adaptor CARD9 is required for adaptive but not innate immunity to oral mucosal Candida albicans infections. (Bishu S, Hernández-Santos N, Simpson-Abelson MR, Huppler AR, Conti HR, Ghilardi N, Mamo AJ, Gaffen SL) Infect Immun 2014 Mar;82(3):1173-80 PMID: 24379290 PMCID: PMC3958019 SCOPUS ID: 2-s2.0-84894271473 01/01/2014       50 Citations
  • Th17 cells confer long-term adaptive immunity to oral mucosal Candida albicans infections. (Hernández-Santos N, Huppler AR, Peterson AC, Khader SA, McKenna KC, Gaffen SL) Mucosal Immunol 2013 Sep;6(5):900-10 PMID: 23250275 PMCID: PMC3608691 SCOPUS ID: 2-s2.0-84883176275 12/20/2012       143 Citations
  • Mucocutaneous candidiasis: the IL-17 pathway and implications for targeted immunotherapy. (Huppler AR, Bishu S, Gaffen SL) Arthritis Res Ther 2012 Jul 23;14(4):217 PMID: 22838497 PMCID: PMC3580547 SCOPUS ID: 2-s2.0-84864359374 07/31/2012       107 Citations
  • Performance of low-risk criteria in the evaluation of young infants with fever: review of the literature. (Huppler AR, Eickhoff JC, Wald ER) Pediatrics 2010 Feb;125(2):228-33 PMID: 20083517 SCOPUS ID: 2-s2.0-76049121516 01/20/2010       104 Citations
  • Protein kinase D 3 is localized in vesicular structures and interacts with vesicle-associated membrane protein 2. (Lu G, Chen J, Espinoza LA, Garfield S, Toshiyuki S, Akiko H, Huppler A, Wang QJ) Cell Signal 2007 Apr;19(4):867-79 PMID: 17196367 SCOPUS ID: 2-s2.0-33847035916 01/02/2007       26 Citations
  • Interaction between protein kinase Cmu and the vanilloid receptor type 1. (Wang Y, Kedei N, Wang M, Wang QJ, Huppler AR, Toth A, Tran R, Blumberg PM) J Biol Chem 2004 Dec 17;279(51):53674-82 PMID: 15471852 SCOPUS ID: 2-s2.0-11144248799 10/09/2004       62 Citations
  • Metal binding and base ionization in the U6 RNA intramolecular stem-loop structure. (Huppler A, Nikstad LJ, Allmann AM, Brow DA, Butcher SE) Nat Struct Biol 2002 Jun;9(6):431-5 PMID: 11992125 SCOPUS ID: 2-s2.0-0036263869 05/07/2002       129 Citations
    • Last update: 03/04/2024