Medical College of Wisconsin
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Anna H. Huppler MD

Anna H. Huppler MD profile photo picture

Assistant Professor

Institution: Medical College of Wisconsin
Department: Pediatrics
Division: Infectious Disease


Research Experience

  • Candida albicans
  • Candidiasis
  • Candidiasis, Oral
  • Chemokines, CC
  • Chemokines, CXC
  • Neutrophils
  • immunology
  • Clinical Expertise

  • Immunocompromised Host
  • Infectious Disease Medicine
  • Invasive Fungal Infections
  • Mycoses
  • Pediatrics
  • Methodologies and Techniques

  • Cell Culture Techniques
  • Cloning, Molecular
  • Enzyme-Linked Immunosorbent Assay
  • Flow Cytometry
  • Models, Animal
  • Polymerase Chain Reaction
  • Reverse Transcriptase Polymerase Chain Reaction
  • Educational Expertise

  • Bacteria
  • Bacterial Infections and Mycoses
  • Fungi
  • Immune System Diseases
  • Parasitic Diseases
  • Virus Diseases
  • Viruses
  • Publications (29)

  • Gammaherpesvirus Usurps Host IL-17 Signaling To Support the Establishment of Chronic Infection. (Jondle CN, Johnson KE, Aurubin C, Sylvester P, Xin G, Cui W, Huppler AR, Tarakanova VL) mBio 2021 04 06;12(2) PMID: 33824206 PMCID: PMC8092251 SCOPUS ID: 2-s2.0-85103513895 04/08/2021    
  • Chemokine CCL28 Is a Potent Therapeutic Agent for Oropharyngeal Candidiasis. (He J, Thomas MA, de Anda J, Lee MW, Van Why E, Simpson P, Wong GCL, Grayson MH, Volkman BF, Huppler AR) Antimicrob Agents Chemother 2020 07 22;64(8) PMID: 32423961 PMCID: PMC7526824 SCOPUS ID: 2-s2.0-85088608725 05/20/2020    
  • Switchable Membrane Remodeling and Antifungal Defense by Metamorphic Chemokine XCL1. (Dishman AF, Lee MW, de Anda J, Lee EY, He J, Huppler AR, Wong GCL, Volkman BF) ACS Infect Dis 2020 05 08;6(5):1204-1213 PMID: 32243126 PMCID: PMC7258946 SCOPUS ID: 2-s2.0-85084720920 04/04/2020       4 Citations
  • Erratum to: Attenuation of Helper T Cell Capacity for TH1 and TH17 Differentiation in Children With Nontuberculous Mycobacterial Infection. (Claeys TA, Rosas Mejia O, Marshall S, Jarzembowski JA, Hayes D, Hull NM, Liyanage NPM, Chun RH, Sulman CG, Huppler AR, Robinson RT) J Infect Dis 2020 05 11;221(11):1917 PMID: 31904837 SCOPUS ID: 2-s2.0-85084695497 01/07/2020    
  • The Interleukin (IL) 17R/IL-22R Signaling Axis Is Dispensable for Vulvovaginal Candidiasis Regardless of Estrogen Status. (Peters BM, Coleman BM, Willems HME, Barker KS, Aggor FEY, Cipolla E, Verma AH, Bishu S, Huppler AH, Bruno VM, Gaffen SL) J Infect Dis 2020 04 07;221(9):1554-1563 PMID: 31805183 PMCID: PMC7137889 SCOPUS ID: 2-s2.0-85078761600 12/06/2019       13 Citations
  • Attenuation of Helper T Cell Capacity for TH1 and TH17 Differentiation in Children With Nontuberculous Mycobacterial Infection. (Claeys TA, Rosas Mejia O, Marshall S, Jarzembowski JA, Hayes D Jr, Hull NM, Liyanage NPM, Chun RH, Sulman CG, Huppler AR, Robinson RT) J Infect Dis 2019 10 22;220(11):1843-1847 PMID: 31332447 PMCID: PMC7325325 SCOPUS ID: 2-s2.0-85073665266 07/25/2019    
  • Pediatric Deep Neck Space Infections: A Medical and Surgical Perspective (Mohandas S, Gregory S, Chun RH, Huppler AR) Journal of Pediatric Infectious Diseases 2019;14(2):43-51 SCOPUS ID: 2-s2.0-85049857631 01/01/2019    
  • The Solution Structure of CCL28 Reveals Structural Lability that Does Not Constrain Antifungal Activity. (Thomas MA, He J, Peterson FC, Huppler AR, Volkman BF) J Mol Biol 2018 09 14;430(18 Pt B):3266-3282 PMID: 29913161 PMCID: PMC6103841 SCOPUS ID: 2-s2.0-85049041059 06/19/2018       6 Citations
  • Development and implementation of an antimicrobial lock therapy guideline in a pediatric hospital. (Zembles TN, Flannery LS, Huppler AR) Am J Health Syst Pharm 2018 03 01;75(5):299-303 PMID: 29472511 SCOPUS ID: 2-s2.0-85042408173 02/24/2018       2 Citations
  • Oral epithelial cells orchestrate innate type 17 responses to Candida albicans through the virulence factor candidalysin. (Verma AH, Richardson JP, Zhou C, Coleman BM, Moyes DL, Ho J, Huppler AR, Ramani K, McGeachy MJ, Mufazalov IA, Waisman A, Kane LP, Biswas PS, Hube B, Naglik JR, Gaffen SL) Sci Immunol 2017 11 03;2(17) PMID: 29101209 PMCID: PMC5881387 SCOPUS ID: 2-s2.0-85034226532 11/05/2017       65 Citations
  • Successful Treatment of Invasive Conidiobolus Infection During Therapy for Acute Lymphoblastic Leukemia. (Erker C, Huppler AR, Walsh TJ, McCormick ME, Suchi M, Bhatt NS, Kehl SC, Southwood J, Harker-Murray P) J Pediatr Hematol Oncol 2018 10;40(7):e446-e449 PMID: 28991126 PMCID: PMC5904005 SCOPUS ID: 2-s2.0-85031495362 10/11/2017       5 Citations
  • Role of Molecular Biomarkers in the Diagnosis of Invasive Fungal Diseases in Children. (Huppler AR, Fisher BT, Lehrnbecher T, Walsh TJ, Steinbach WJ) J Pediatric Infect Dis Soc 2017 Sep 01;6(suppl_1):S32-S44 PMID: 28927202 PMCID: PMC5907877 SCOPUS ID: 2-s2.0-85045043737 09/21/2017       24 Citations
  • The Goldilocks model of immune symbiosis with Mycobacteria and Candida colonizers. (Robinson RT, Huppler AR) Cytokine 2017 09;97:49-65 PMID: 28570933 PMCID: PMC5765749 SCOPUS ID: 2-s2.0-85019740661 06/02/2017       10 Citations
  • Editorial: Fake it 'til you make it: mast cells acquire IL-17 exogenously. (Huppler AR, Gaffen SL) J Leukoc Biol 2016 09;100(3):445-6 PMID: 27587375 SCOPUS ID: 2-s2.0-84984998133 09/03/2016       2 Citations
  • An Optimized Voriconazole Dosing Strategy to Achieve Therapeutic Serum Concentrations in Children Younger than 2 Years Old. (Zembles TN, Thompson NE, Havens PL, Kaufman BA, Huppler AR) Pharmacotherapy 2016 10;36(10):1102-1108 PMID: 27548272 SCOPUS ID: 2-s2.0-84990831275 08/23/2016       6 Citations
  • Neutrophils Do Not Express IL-17A in the Context of Acute Oropharyngeal Candidiasis. (Huppler AR, Verma AH, Conti HR, Gaffen SL) Pathogens 2015 Jul 24;4(3):559-72 PMID: 26213975 PMCID: PMC4584272 07/28/2015    
  • A Candida albicans Strain Expressing Mammalian Interleukin-17A Results in Early Control of Fungal Growth during Disseminated Infection. (Huppler AR, Whibley N, Woolford CA, Childs EE, He J, Biswas PS, McGeachy MJ, Mitchell AP, Gaffen SL) Infect Immun 2015 Sep;83(9):3684-92 PMID: 26150537 PMCID: PMC4534662 SCOPUS ID: 2-s2.0-84939513442 07/08/2015       2 Citations
  • Correction: Role of Neutrophils in IL-17-Dependent Immunity to Mucosal Candidiasis. (Huppler AR, Conti HR, Hernández-Santos N, Darville T, Biswas PS, Gaffen SL) J Immunol 2015 Feb 01;194(3):1382 PMID: 25596301 01/18/2015    
  • Oral-resident natural Th17 cells and γδ T cells control opportunistic Candida albicans infections. (Conti HR, Peterson AC, Brane L, Huppler AR, Hernández-Santos N, Whibley N, Garg AV, Simpson-Abelson MR, Gibson GA, Mamo AJ, Osborne LC, Bishu S, Ghilardi N, Siebenlist U, Watkins SC, Artis D, McGeachy MJ, Gaffen SL) J Exp Med 2014 Sep 22;211(10):2075-84 PMID: 25200028 PMCID: PMC4172215 SCOPUS ID: 2-s2.0-84907202739 09/10/2014       141 Citations
  • An essential role of interleukin-17 receptor signaling in the development of autoimmune glomerulonephritis. (Ramani K, Pawaria S, Maers K, Huppler AR, Gaffen SL, Biswas PS) J Leukoc Biol 2014 Sep;96(3):463-72 PMID: 24935958 PMCID: PMC4138200 SCOPUS ID: 2-s2.0-84907329820 06/18/2014       28 Citations
  • Animal models for candidiasis. (Conti HR, Huppler AR, Whibley N, Gaffen SL) Curr Protoc Immunol 2014 Apr 02;105:19.6.1-19.6.17 PMID: 24700323 PMCID: PMC4088949 SCOPUS ID: 2-s2.0-84922696733 04/05/2014       50 Citations
  • Role of neutrophils in IL-17-dependent immunity to mucosal candidiasis. (Huppler AR, Conti HR, Hernández-Santos N, Darville T, Biswas PS, Gaffen SL) J Immunol 2014 Feb 15;192(4):1745-52 PMID: 24442441 PMCID: PMC3946223 SCOPUS ID: 2-s2.0-84894270649 01/21/2014       77 Citations
  • The adaptor CARD9 is required for adaptive but not innate immunity to oral mucosal Candida albicans infections. (Bishu S, Hernández-Santos N, Simpson-Abelson MR, Huppler AR, Conti HR, Ghilardi N, Mamo AJ, Gaffen SL) Infect Immun 2014 Mar;82(3):1173-80 PMID: 24379290 PMCID: PMC3958019 SCOPUS ID: 2-s2.0-84894271473 01/01/2014       43 Citations
  • Th17 cells confer long-term adaptive immunity to oral mucosal Candida albicans infections. (Hernández-Santos N, Huppler AR, Peterson AC, Khader SA, McKenna KC, Gaffen SL) Mucosal Immunol 2013 Sep;6(5):900-10 PMID: 23250275 PMCID: PMC3608691 SCOPUS ID: 2-s2.0-84883176275 12/20/2012       112 Citations
  • Mucocutaneous candidiasis: the IL-17 pathway and implications for targeted immunotherapy. (Huppler AR, Bishu S, Gaffen SL) Arthritis Res Ther 2012 Jul 23;14(4):217 PMID: 22838497 PMCID: PMC3580547 SCOPUS ID: 2-s2.0-84864359374 07/31/2012       78 Citations
  • Performance of low-risk criteria in the evaluation of young infants with fever: review of the literature. (Huppler AR, Eickhoff JC, Wald ER) Pediatrics 2010 Feb;125(2):228-33 PMID: 20083517 SCOPUS ID: 2-s2.0-76049121516 01/20/2010       74 Citations
  • Protein kinase D 3 is localized in vesicular structures and interacts with vesicle-associated membrane protein 2. (Lu G, Chen J, Espinoza LA, Garfield S, Toshiyuki S, Akiko H, Huppler A, Wang QJ) Cell Signal 2007 Apr;19(4):867-79 PMID: 17196367 SCOPUS ID: 2-s2.0-33847035916 01/02/2007       25 Citations
  • Interaction between protein kinase Cmu and the vanilloid receptor type 1. (Wang Y, Kedei N, Wang M, Wang QJ, Huppler AR, Toth A, Tran R, Blumberg PM) J Biol Chem 2004 Dec 17;279(51):53674-82 PMID: 15471852 SCOPUS ID: 2-s2.0-11144248799 10/09/2004       60 Citations
  • Metal binding and base ionization in the U6 RNA intramolecular stem-loop structure. (Huppler A, Nikstad LJ, Allmann AM, Brow DA, Butcher SE) Nat Struct Biol 2002 Jun;9(6):431-5 PMID: 11992125 SCOPUS ID: 2-s2.0-0036263869 05/07/2002       122 Citations
  • Last update: 04/12/2021