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Brian Bennett D.Phil.

Brian Bennett D.Phil.

Professor and Chair

Institution: Marquette University
Department: Physics

Member of the Cancer Center


Research Experience

  • Biochemistry
  • Biophysics
  • Catalysis
  • Chemistry, Bioinorganic
  • Electron Spin Resonance Spectroscopy
  • Kinetics
  • Magnetic Resonance Spectroscopy
  • Metalloproteins
  • Structure-Activity Relationship
  • Transition Elements
  • Methodologies and Techniques

  • Electron Spin Resonance Spectroscopy
  • Kinetics
  • Rapid-freeze-quench
  • Leadership Positions

  • MCW Graduate School Admissions & Welfare Cttee (2005 - 2007)
  • MCW Admissions Cttee [Medical School] (2002 - 2013)
  • MCW Graduate School IDP Recruitment Cttee (2007 - 2009)
  • MCW Graduate School Awards Cttee (2003 - 2005)
  • MCW Academic Oversight Cttee (2008 - 2010)
  • HLC-NCA Academic Accreditation Criterion 4 Self Study Cttee (2006)
  • MCW Curriculums and Programs Cttee (2007)
  • MCW Graduate School Course Evaluations Cttee (Chair, 2007 - 2010)
  • MCW Graduate School Admissions Cttee (2009 - 2014)
  • MCW Faculty Credentials Committee (2011-13; Chair 2013-14)
  • Physics Department Chair, MU (2014 - present)
  • National Biomedical EPR Center, Assoc. Dir. & Service Dir. (2003-2014)
  • MCW Program / Core Facilities

  • National Biomedical Electron Paramagnetic Resonance Center
  • Educational Expertise

  • Biochemistry
  • Biophysics
  • Chemistry, Bioinorganic
  • Electron Spin Resonance Spectroscopy
  • Spectroscopy
  • Publications

  • Low-Temperature EPR Spectroscopy as a Probe-Free Technique for Monitoring Oxidants Formed in Tumor Cells and Tissues: Implications in Drug Resistance and OXPHOS-Targeted Therapies. (Kalyanaraman B, Cheng G, Zielonka J, Bennett B) Cell Biochem Biophys 2018 Sep 26 PMID: 30259334 09/28/2018    
  • Analyzing the function of the insert region found between the α and β-subunits in the eukaryotic nitrile hydratase from Monosiga brevicollis. (Yang X, Bennett B, Holz RC) Arch Biochem Biophys 2018 Nov 01;657:1-7 PMID: 30205086 PMCID: PMC6201762 09/12/2018    
  • Sdha+/- Rats Display Minimal Muscle Pathology Without Significant Behavioral or Biochemical Abnormalities. (Siebers EM, Choi MJ, Tinklenberg JA, Beatka MJ, Ayres S, Meng H, Helbling DC, Takizawa A, Bennett B, Garces AM, Dias Duarte Machado LG, Dimmock D, Dwinell MR, Geurts AM, Lawlor MW) J Neuropathol Exp Neurol 2018 Aug 01;77(8):665-672 PMID: 29850869 PMCID: PMC6044411 06/01/2018    
  • Detection of mitochondria-generated reactive oxygen species in cells using multiple probes and methods: Potentials, pitfalls, and the future. (Cheng G, Zielonka M, Dranka B, Kumar SN, Myers CR, Bennett B, Garces AM, Dias Duarte Machado LG, Thiebaut D, Ouari O, Hardy M, Zielonka J, Kalyanaraman B) J Biol Chem 2018 06 29;293(26):10363-10380 PMID: 29739855 PMCID: PMC6028982 05/10/2018       3 Citations
  • Teaching the basics of reactive oxygen species and their relevance to cancer biology: Mitochondrial reactive oxygen species detection, redox signaling, and targeted therapies. (Kalyanaraman B, Cheng G, Hardy M, Ouari O, Bennett B, Zielonka J) Redox Biol 2018 05;15:347-362 PMID: 29306792 PMCID: PMC5756055 01/08/2018       12 Citations
  • Biocompatible Copper Oxide Nanoparticle Composites from Cellulose and Chitosan: Facile Synthesis, Unique Structure, and Antimicrobial Activity. (Tran CD, Makuvaza J, Munson E, Bennett B) ACS Appl Mater Interfaces 2017 Dec 13;9(49):42503-42515 PMID: 29152974 11/21/2017       4 Citations
  • Multiple States of Nitrile Hydratase from Rhodococcus equi TG328-2: Structural and Mechanistic Insights from Electron Paramagnetic Resonance and Density Functional Theory Studies. (Stein N, Gumataotao N, Hajnas N, Wu R, Lankathilaka KPW, Bornscheuer UT, Liu D, Fiedler AT, Holz RC, Bennett B) Biochemistry 2017 06 20;56(24):3068-3077 PMID: 28520398 PMCID: PMC5821057 05/19/2017       2 Citations
  • Mito-Apocynin Prevents Mitochondrial Dysfunction, Microglial Activation, Oxidative Damage, and Progressive Neurodegeneration in MitoPark Transgenic Mice. (Langley M, Ghosh A, Charli A, Sarkar S, Ay M, Luo J, Zielonka J, Brenza T, Bennett B, Jin H, Ghaisas S, Schlichtmann B, Kim D, Anantharam V, Kanthasamy A, Narasimhan B, Kalyanaraman B, Kanthasamy AG) Antioxid Redox Signal 2017 Nov 10;27(14):1048-1066 PMID: 28375739 PMCID: PMC5651937 04/05/2017       17 Citations
  • The iron-type nitrile hydratase activator protein is a GTPase. (Gumataotao N, Lankathilaka KP, Bennett B, Holz RC) Biochem J 2017 01 15;474(2):247-258 PMID: 27807009 11/04/2016       2 Citations
  • A cobalt-containing eukaryotic nitrile hydratase. (Martinez S, Yang X, Bennett B, Holz RC) Biochim Biophys Acta Proteins Proteom 2017 Jan;1865(1):107-112 PMID: 27693250 10/04/2016       6 Citations
  • Increasing tetrahydrobiopterin in cardiomyocytes adversely affects cardiac redox state and mitochondrial function independently of changes in NO production. (Sethumadhavan S, Whitsett J, Bennett B, Ionova IA, Pieper GM, Vasquez-Vivar J) Free Radic Biol Med 2016 Apr;93:1-11 PMID: 26826575 PMCID: PMC5498285 01/31/2016       5 Citations
  • Potentially diagnostic electron paramagnetic resonance spectra elucidate the underlying mechanism of mitochondrial dysfunction in the deoxyguanosine kinase deficient rat model of a genetic mitochondrial DNA depletion syndrome. (Bennett B, Helbling D, Meng H, Jarzembowski J, Geurts AM, Friederich MW, Van Hove JLK, Lawlor MW, Dimmock DP) Free Radic Biol Med 2016 Mar;92:141-151 PMID: 26773591 PMCID: PMC5047058 01/17/2016       7 Citations
  • EPR Methods for Biological Cu(II): L-Band CW and NARS. (Bennett B, Kowalski JM) Methods Enzymol 2015;563:341-61 PMID: 26478491 PMCID: PMC4772423 10/20/2015       5 Citations
  • Inhibition of the dapE-Encoded N-Succinyl-L,L-diaminopimelic Acid Desuccinylase from Neisseria meningitidis by L-Captopril. (Starus A, Nocek B, Bennett B, Larrabee JA, Shaw DL, Sae-Lee W, Russo MT, Gillner DM, Makowska-Grzyska M, Joachimiak A, Holz RC) Biochemistry 2015 Aug 11;54(31):4834-44 PMID: 26186504 PMCID: PMC4671288 07/18/2015       5 Citations
  • Correlations between the Electronic Properties of Shewanella oneidensis Cytochrome c Nitrite Reductase (ccNiR) and Its Structure: Effects of Heme Oxidation State and Active Site Ligation. (Stein N, Love D, Judd ET, Elliott SJ, Bennett B, Pacheco AA) Biochemistry 2015 Jun 23;54(24):3749-58 PMID: 26042961 PMCID: PMC4743497 06/05/2015    
  • Conformational dynamics of metallo-β-lactamase CcrA during catalysis investigated by using DEER spectroscopy. (Aitha M, Moritz L, Sahu ID, Sanyurah O, Roche Z, McCarrick R, Lorigan GA, Bennett B, Crowder MW) J Biol Inorg Chem 2015 Apr;20(3):585-94 PMID: 25827593 PMCID: PMC4733638 04/02/2015       9 Citations
  • Homoleptic nickel(II) complexes of redox-tunable pincer-type ligands. (Hewage JS, Wanniarachchi S, Morin TJ, Liddle BJ, Banaszynski M, Lindeman SV, Bennett B, Gardinier JR) Inorg Chem 2014 Oct 06;53(19):10070-84 PMID: 25222027 PMCID: PMC5047063 09/16/2014       7 Citations
  • Spectroscopic and mechanistic studies of heterodimetallic forms of metallo-β-lactamase NDM-1. (Yang H, Aitha M, Marts AR, Hetrick A, Bennett B, Crowder MW, Tierney DL) J Am Chem Soc 2014 May 21;136(20):7273-85 PMID: 24754678 PMCID: PMC4046764 04/24/2014       33 Citations
  • Dilution of dipolar interactions in a spin-labeled, multimeric metalloenzyme for DEER studies. (Aitha M, Richmond TK, Hu Z, Hetrick A, Reese R, Gunther A, McCarrick R, Bennett B, Crowder MW) J Inorg Biochem 2014 Jul;136:40-6 PMID: 24742748 PMCID: PMC4733626 04/20/2014       6 Citations
  • Shewanella oneidensis cytochrome c nitrite reductase (ccNiR) does not disproportionate hydroxylamine to ammonia and nitrite, despite a strongly favorable driving force. (Youngblut M, Pauly DJ, Stein N, Walters D, Conrad JA, Moran GR, Bennett B, Pacheco AA) Biochemistry 2014 Apr 08;53(13):2136-44 PMID: 24645742 PMCID: PMC5047060 03/22/2014       3 Citations
  • Moving difference (MDIFF) non-adiabatic rapid sweep (NARS) EPR of copper(II). (Hyde JS, Bennett B, Kittell AW, Kowalski JM, Sidabras JW) J Magn Reson 2013 Nov;236:15-25 PMID: 24036469 PMCID: PMC3919454 09/17/2013       8 Citations
  • Responses of Mn2+ speciation in Deinococcus radiodurans and Escherichia coli to γ-radiation by advanced paramagnetic resonance methods. (Sharma A, Gaidamakova EK, Matrosova VY, Bennett B, Daly MJ, Hoffman BM) Proc Natl Acad Sci U S A 2013 Apr 09;110(15):5945-50 PMID: 23536297 PMCID: PMC3625348 03/29/2013       32 Citations
  • Electronic communication across diamagnetic metal bridges: a homoleptic gallium(III) complex of a redox-active diarylamido-based ligand and its oxidized derivatives. (Liddle BJ, Wanniarachchi S, Hewage JS, Lindeman SV, Bennett B, Gardinier JR) Inorg Chem 2012 Dec 03;51(23):12720-8 PMID: 23163736 PMCID: PMC3601749 11/21/2012       7 Citations
  • Photochemistry of furyl- and thienyldiazomethanes: spectroscopic characterization of triplet 3-thienylcarbene. (Pharr CR, Kopff LA, Bennett B, Reid SA, McMahon RJ) J Am Chem Soc 2012 Apr 11;134(14):6443-54 PMID: 22463599 PMCID: PMC3994982 04/03/2012       10 Citations
  • Structural and kinetic studies on metallo-β-lactamase IMP-1. (Griffin DH, Richmond TK, Sanchez C, Moller AJ, Breece RM, Tierney DL, Bennett B, Crowder MW) Biochemistry 2011 Oct 25;50(42):9125-34 PMID: 21928807 09/21/2011       31 Citations
  • Pyrazolyl methyls prescribe the electronic properties of iron(II) tetra(pyrazolyl)lutidine chloride complexes. (Morin TJ, Wanniarachchi S, Gwengo C, Makura V, Tatlock HM, Lindeman SV, Bennett B, Long GJ, Grandjean F, Gardinier JR) Dalton Trans 2011 Aug 21;40(31):8024-34 PMID: 21720641 07/02/2011       11 Citations
  • Using sterics to promote reactivity in fac-Re(CO)3 complexes of some 'non-innocent' NNN-pincer ligands. (Wanniarachchi S, Liddle BJ, Toussaint J, Lindeman SV, Bennett B, Gardinier JR) Dalton Trans 2011 Sep 21;40(35):8776-87 PMID: 21455516 04/02/2011       17 Citations
  • Avoiding premature oxidation during the binding of Cu(II) to a dithiolate site in BsSCO. A rapid freeze-quench EPR study. (Bennett B, Hill BC) FEBS Lett 2011 Mar 23;585(6):861-4 PMID: 21333651 PMCID: PMC3109496 02/22/2011       11 Citations
  • Spin hamiltonian parameters for Cu(II)-prion peptide complexes from L-band electron paramagnetic resonance spectroscopy. (Kowalski JM, Bennett B) J Am Chem Soc 2011 Feb 16;133(6):1814-23 PMID: 21265507 PMCID: PMC3150385 01/27/2011       8 Citations
  • Converting GLX2-1 into an active glyoxalase II. (Limphong P, Adams NE, Rouhier MF, McKinney RM, Naylor M, Bennett B, Makaroff CA, Crowder MW) Biochemistry 2010 Sep 21;49(37):8228-36 PMID: 20715794 PMCID: PMC2939260 08/19/2010       7 Citations
  • Low temperature photo-oxidation of chloroperoxidase Compound II. (Yuan X, Sheng X, Horner JH, Bennett B, Fung LW, Newcomb M) J Inorg Biochem 2010 Nov;104(11):1156-63 PMID: 20674981 PMCID: PMC2963949 08/03/2010       3 Citations
  • Chemical switching behaviour of tricarbonylrhenium(I) complexes of a new redox active 'pincer' ligand. (Wanniarachchi S, Liddle BJ, Toussaint J, Lindeman SV, Bennett B, Gardinier JR) Dalton Trans 2010 Apr 07;39(13):3167-9 PMID: 20449442 05/08/2010       24 Citations
  • The metal ion requirements of Arabidopsis thaliana Glx2-2 for catalytic activity. (Limphong P, McKinney RM, Adams NE, Makaroff CA, Bennett B, Crowder MW) J Biol Inorg Chem 2010 Feb;15(2):249-58 PMID: 19834746 10/17/2009       4 Citations
  • Motion of the zinc ions in catalysis by a dizinc metallo-beta-lactamase. (Breece RM, Hu Z, Bennett B, Crowder MW, Tierney DL) J Am Chem Soc 2009 Aug 26;131(33):11642-3 PMID: 19653676 PMCID: PMC3571662 08/06/2009       25 Citations
  • Differential binding of Co(II) and Zn(II) to metallo-beta-lactamase Bla2 from Bacillus anthracis. (Hawk MJ, Breece RM, Hajdin CE, Bender KM, Hu Z, Costello AL, Bennett B, Tierney DL, Crowder MW) J Am Chem Soc 2009 Aug 05;131(30):10753-62 PMID: 19588962 PMCID: PMC3295577 07/11/2009       32 Citations
  • Human glyoxalase II contains an Fe(II)Zn(II) center but is active as a mononuclear Zn(II) enzyme. (Limphong P, McKinney RM, Adams NE, Bennett B, Makaroff CA, Gunasekera T, Crowder MW) Biochemistry 2009 Jun 16;48(23):5426-34 PMID: 19413286 PMCID: PMC4627686 05/06/2009       22 Citations
  • EPR of Cu2+ prion protein constructs at 2 GHz using the g(perpendicular) region to characterize nitrogen ligation. (Hyde JS, Bennett B, Walter ED, Millhauser GL, Sidabras JW, Antholine WE) Biophys J 2009 Apr 22;96(8):3354-62 PMID: 19383478 PMCID: PMC2718275 04/23/2009       10 Citations
  • Heterologous expression and purification of Vibrio proteolyticus (Aeromonas proteolytica) aminopeptidase: a rapid protocol. (Hartley M, Yong W, Bennett B) Protein Expr Purif 2009 Jul;66(1):91-101 PMID: 19233285 PMCID: PMC2669716 02/24/2009       8 Citations
  • Structure and mechanism of copper- and nickel-substituted analogues of metallo-beta-lactamase L1. (Hu Z, Spadafora LJ, Hajdin CE, Bennett B, Crowder MW) Biochemistry 2009 Apr 07;48(13):2981-9 PMID: 19228020 PMCID: PMC2671888 02/21/2009       18 Citations
  • Analyzing the binding of Co(II)-specific inhibitors to the methionyl aminopeptidases from Escherichia coli and Pyrococcus furiosus. (Mitra S, Sheppard G, Wang J, Bennett B, Holz RC) J Biol Inorg Chem 2009 May;14(4):573-85 PMID: 19198897 PMCID: PMC2678238 02/10/2009       5 Citations
  • Substrate binding preferences and pka determinations of a nitrile hydratase model complex: variable solvent coordination to [(bmmp-TASN)Fe]OTf. (O'Toole MG, Bennett B, Mashuta MS, Grapperhaus CA) Inorg Chem 2009 Mar 02;48(5):2300-8 PMID: 19166306 PMCID: PMC2754792 01/27/2009       9 Citations
  • Analyzing the catalytic role of Asp97 in the methionine aminopeptidase from Escherichia coli. (Mitra S, Job KM, Meng L, Bennett B, Holz RC) FEBS J 2008 Dec;275(24):6248-59 PMID: 19019076 PMCID: PMC2699115 11/21/2008       6 Citations
  • Trapping and characterization of a reaction intermediate in carbapenem hydrolysis by B. cereus metallo-beta-lactamase. (Tioni MF, Llarrull LI, Poeylaut-Palena AA, Martí MA, Saggu M, Periyannan GR, Mata EG, Bennett B, Murgida DH, Vila AJ) J Am Chem Soc 2008 Nov 26;130(47):15852-63 PMID: 18980308 PMCID: PMC2645938 11/05/2008       54 Citations
  • Mutation of H63 and its catalytic affect on the methionine aminopeptidase from Escherichia coli. (Mitra S, Bennett B, Holz RC) Biochim Biophys Acta 2009 Jan;1794(1):137-43 PMID: 18952013 PMCID: PMC2674292 10/28/2008    
  • Kinetic and spectroscopic analysis of the catalytic role of H79 in the methionine aminopeptidase from Escherichia coli. (Watterson SJ, Mitra S, Swierczek SI, Bennett B, Holz RC) Biochemistry 2008 Nov 11;47(45):11885-93 PMID: 18855426 PMCID: PMC2720795 10/16/2008       8 Citations
  • Role of the Zn1 and Zn2 sites in metallo-beta-lactamase L1. (Hu Z, Periyannan G, Bennett B, Crowder MW) J Am Chem Soc 2008 Oct 29;130(43):14207-16 PMID: 18831550 PMCID: PMC2678235 10/04/2008       52 Citations
  • Arabidopsis thaliana GLX2-1 contains a dinuclear metal binding site, but is not a glyoxalase 2. (Limphong P, Crowder MW, Bennett B, Makaroff CA) Biochem J 2009 Jan 01;417(1):323-30 PMID: 18782082 PMCID: PMC2677751 09/11/2008       6 Citations
  • The dapE-encoded N-succinyl-L,L-diaminopimelic acid desuccinylase from Haemophilus influenzae contains two active-site histidine residues. (Gillner DM, Bienvenue DL, Nocek BP, Joachimiak A, Zachary V, Bennett B, Holz RC) J Biol Inorg Chem 2009 Jan;14(1):1-10 PMID: 18712420 PMCID: PMC2678232 08/21/2008       13 Citations
  • First-row transition-metal complexes of a new pentadentate ligand, alpha,alpha,alpha',alpha'-tetra(pyrazolyl)lutidine. (Morin TJ, Bennett B, Lindeman SV, Gardinier JR) Inorg Chem 2008 Sep 01;47(17):7468-70 PMID: 18681427 PMCID: PMC2754785 08/07/2008       17 Citations
  • Spectroscopic studies on Arabidopsis ETHE1, a glyoxalase II-like protein. (Holdorf MM, Bennett B, Crowder MW, Makaroff CA) J Inorg Biochem 2008 Sep;102(9):1825-30 PMID: 18656261 PMCID: PMC2556177 07/29/2008       15 Citations
  • Metal content of metallo-beta-lactamase L1 is determined by the bioavailability of metal ions. (Hu Z, Gunasekera TS, Spadafora L, Bennett B, Crowder MW) Biochemistry 2008 Jul 29;47(30):7947-53 PMID: 18597493 PMCID: PMC2750885 07/04/2008       28 Citations
  • Conformational changes in the metallo-beta-lactamase ImiS during the catalytic reaction: an EPR spectrokinetic study of Co(II)-spin label interactions. (Sharma N, Hu Z, Crowder MW, Bennett B) J Am Chem Soc 2008 Jul 02;130(26):8215-22 PMID: 18528987 PMCID: PMC2574873 06/06/2008       13 Citations
  • MoV electron paramagnetic resonance of sulfite oxidase revisited: the low-pH chloride signal. (Doonan CJ, Wilson HL, Bennett B, Prince RC, Rajagopalan KV, George GN) Inorg Chem 2008 Mar 17;47(6):2033-8 PMID: 18271529 PMCID: PMC2841525 02/15/2008       24 Citations
  • Structure and metal binding properties of ZnuA, a periplasmic zinc transporter from Escherichia coli. (Yatsunyk LA, Easton JA, Kim LR, Sugarbaker SA, Bennett B, Breece RM, Vorontsov II, Tierney DL, Crowder MW, Rosenzweig AC) J Biol Inorg Chem 2008 Feb;13(2):271-88 PMID: 18027003 PMCID: PMC2630496 11/21/2007       65 Citations
  • Evidence for a dinuclear active site in the metallo-beta-lactamase BcII with substoichiometric Co(II). A new model for metal uptake. (Llarrull LI, Tioni MF, Kowalski J, Bennett B, Vila AJ) J Biol Chem 2007 Oct 19;282(42):30586-95 PMID: 17715135 08/24/2007       49 Citations
  • Modified active site coordination in a clinical mutant of sulfite oxidase. (Doonan CJ, Wilson HL, Rajagopalan KV, Garrett RM, Bennett B, Prince RC, George GN) J Am Chem Soc 2007 Aug 01;129(30):9421-8 PMID: 17608478 07/05/2007       23 Citations
  • X-ray crystallographic characterization of the Co(II)-substituted Tris-bound form of the aminopeptidase from Aeromonas proteolytica. (Munih P, Moulin A, Stamper CC, Bennett B, Ringe D, Petsko GA, Holz RC) J Inorg Biochem 2007 Aug;101(8):1099-107 PMID: 17574677 06/19/2007       12 Citations
  • Asp-120 locates Zn2 for optimal metallo-beta-lactamase activity. (Llarrull LI, Fabiane SM, Kowalski JM, Bennett B, Sutton BJ, Vila AJ) J Biol Chem 2007 Jun 22;282(25):18276-85 PMID: 17426028 04/12/2007       35 Citations
  • The metallo-beta-lactamase GOB is a mono-Zn(II) enzyme with a novel active site. (Morán-Barrio J, González JM, Lisa MN, Costello AL, Peraro MD, Carloni P, Bennett B, Tierney DL, Limansky AS, Viale AM, Vila AJ) J Biol Chem 2007 Jun 22;282(25):18286-93 PMID: 17403673 04/04/2007       53 Citations
  • Characterization of the catalytically active Mn(II)-loaded argE-encoded N-acetyl-L-ornithine deacetylase from Escherichia coli. (McGregor WC, Swierczek SI, Bennett B, Holz RC) J Biol Inorg Chem 2007 Jun;12(5):603-13 PMID: 17333302 03/03/2007       8 Citations
  • Experimental evidence for a metallohydrolase mechanism in which the nucleophile is not delivered by a metal ion: EPR spectrokinetic and structural studies of aminopeptidase from Vibrio proteolyticus. (Kumar A, Periyannan GR, Narayanan B, Kittell AW, Kim JJ, Bennett B) Biochem J 2007 May 01;403(3):527-36 PMID: 17238863 PMCID: PMC1876372 01/24/2007       10 Citations
  • Probing the reaction mechanism of the D-ala-D-ala dipeptidase, VanX, by using stopped-flow kinetic and rapid-freeze quench EPR studies on the Co(II)-substituted enzyme. (Matthews ML, Periyannan G, Hajdin C, Sidgel TK, Bennett B, Crowder MW) J Am Chem Soc 2006 Oct 11;128(40):13050-1 PMID: 17017774 PMCID: PMC2547881 10/05/2006       13 Citations
  • Mechanistic studies on the mononuclear ZnII-containing metallo-beta-lactamase ImiS from Aeromonas sobria. (Sharma NP, Hajdin C, Chandrasekar S, Bennett B, Yang KW, Crowder MW) Biochemistry 2006 Sep 05;45(35):10729-38 PMID: 16939225 PMCID: PMC2597473 08/31/2006       47 Citations
  • Sequential binding of cobalt(II) to metallo-beta-lactamase CcrA. (Periyannan GR, Costello AL, Tierney DL, Yang KW, Bennett B, Crowder MW) Biochemistry 2006 Jan 31;45(4):1313-20 PMID: 16430228 01/25/2006       36 Citations
  • Kinetic and spectroscopic characterization of the E134A- and E134D-altered dapE-encoded N-succinyl-L,L-diaminopimelic acid desuccinylase from Haemophilus influenzae. (Davis R, Bienvenue D, Swierczek SI, Gilner DM, Rajagopal L, Bennett B, Holz RC) J Biol Inorg Chem 2006 Mar;11(2):206-16 PMID: 16421726 01/20/2006       17 Citations
  • Spectroscopic and thermodynamic characterization of the E151D and E151A altered leucine aminopeptidases from Aeromonas proteolytica. (Bzymek KP, Swierczek SI, Bennett B, Holz RC) Inorg Chem 2005 Nov 14;44(23):8574-80 PMID: 16270998 11/08/2005       7 Citations
  • Structural studies on a mitochondrial glyoxalase II. (Marasinghe GP, Sander IM, Bennett B, Periyannan G, Yang KW, Makaroff CA, Crowder MW) J Biol Chem 2005 Dec 09;280(49):40668-75 PMID: 16227621 PMCID: PMC1343529 10/18/2005       54 Citations
  • argE-encoded N-acetyl-L-ornithine deacetylase from Escherichia coli contains a dinuclear metalloactive site. (McGregor WC, Swierczek SI, Bennett B, Holz RC) J Am Chem Soc 2005 Oct 12;127(40):14100-7 PMID: 16201833 10/06/2005       21 Citations
  • The octarepeat domain of the prion protein binds Cu(II) with three distinct coordination modes at pH 7.4. (Chattopadhyay M, Walter ED, Newell DJ, Jackson PJ, Aronoff-Spencer E, Peisach J, Gerfen GJ, Bennett B, Antholine WE, Millhauser GL) J Am Chem Soc 2005 Sep 14;127(36):12647-56 PMID: 16144413 PMCID: PMC2909831 09/08/2005       172 Citations
  • Kinetic, spectroscopic, and X-ray crystallographic characterization of the functional E151H aminopeptidase from Aeromonas proteolytica. (Bzymek KP, Moulin A, Swierczek SI, Ringe D, Petsko GA, Bennett B, Holz RC) Biochemistry 2005 Sep 13;44(36):12030-40 PMID: 16142900 09/07/2005       12 Citations
  • Spectroscopic studies on cobalt(II)-substituted metallo-beta-lactamase ImiS from Aeromonas veronii bv. sobria. (Crawford PA, Yang KW, Sharma N, Bennett B, Crowder MW) Biochemistry 2005 Apr 05;44(13):5168-76 PMID: 15794654 03/30/2005       52 Citations
  • Both nucleophile and substrate bind to the catalytic Fe(II)-center in the type-II methionyl aminopeptidase from Pyrococcus furiosus. (Copik AJ, Waterson S, Swierczek SI, Bennett B, Holz RC) Inorg Chem 2005 Mar 07;44(5):1160-2 PMID: 15732944 03/01/2005       19 Citations
  • A five-coordinate metal center in Co(II)-substituted VanX. (Breece RM, Costello A, Bennett B, Sigdel TK, Matthews ML, Tierney DL, Crowder MW) J Biol Chem 2005 Mar 25;280(12):11074-81 PMID: 15657055 01/20/2005       31 Citations
  • Direct evidence that the reaction intermediate of metallo-beta-lactamase L1 is metal bound. (Garrity JD, Bennett B, Crowder MW) Biochemistry 2005 Jan 25;44(3):1078-87 PMID: 15654764 01/19/2005       62 Citations
  • EPR and X-ray crystallographic characterization of the product-bound form of the MnII-loaded methionyl aminopeptidase from Pyrococcus furiosus. (Copik AJ, Nocek BP, Swierczek SI, Ruebush S, Jang SB, Meng L, D'souza VM, Peters JW, Bennett B, Holz RC) Biochemistry 2005 Jan 11;44(1):121-9 PMID: 15628852 01/05/2005       20 Citations
  • An informatics search for the low-molecular weight chromium-binding peptide. (Dinakarpandian D, Morrissette V, Chaudhary S, Amini K, Bennett B, Van Horn JD) BMC Chem Biol 2004 Dec 16;4(1):2 PMID: 15603587 PMCID: PMC539358 12/18/2004    
  • Characterization of the active site and insight into the binding mode of the anti-angiogenesis agent fumagillin to the manganese(II)-loaded methionyl aminopeptidase from Escherichia coli. (D'souza VM, Brown RS, Bennett B, Holz RC) J Biol Inorg Chem 2005 Jan;10(1):41-50 PMID: 15578241 12/04/2004       9 Citations
  • Mononuclear nitrogen/sulfur-ligated cobalt(II) methoxide complexes: structural, EPR, paramagnetic 1H NMR, and electrochemical investigations. (Tubbs KJ, Szajna E, Bennett B, Halfen JA, Watkins RW, Arif AM, Berreau LM) Dalton Trans 2004 Aug 21(16):2398-9 PMID: 15303148 08/11/2004       8 Citations
  • Spectroscopic and X-ray crystallographic characterization of bestatin bound to the aminopeptidase from Aeromonas (Vibrio) proteolytica. (Stamper CC, Bienvenue DL, Bennett B, Ringe D, Petsko GA, Holz RC) Biochemistry 2004 Aug 03;43(30):9620-8 PMID: 15274616 07/28/2004       26 Citations
  • Substrate specificity, metal binding properties, and spectroscopic characterization of the DapE-encoded N-succinyl-L,L-diaminopimelic acid desuccinylase from Haemophilus influenzae. (Bienvenue DL, Gilner DM, Davis RS, Bennett B, Holz RC) Biochemistry 2003 Sep 16;42(36):10756-63 PMID: 12962500 09/10/2003       30 Citations
  • Mononuclear N3S(thioether)-ligated copper(II) methoxide complexes: synthesis, characterization, and hydrolytic reactivity. (Tubbs KJ, Fuller AL, Bennett B, Arif AM, Berreau LM) Inorg Chem 2003 Aug 11;42(16):4790-1 PMID: 12895095 08/05/2003       31 Citations
  • Structurally distinct active sites in the copper(II)-substituted aminopeptidases from Aeromonas proteolytica and Escherichia coli. (Bennett B, Antholine WE, D'souza VM, Chen G, Ustinyuk L, Holz RC) J Am Chem Soc 2002 Nov 06;124(44):13025-34 PMID: 12405829 PMCID: PMC2669718 10/31/2002       29 Citations
  • Synthesis, Molecular Structure, and Reactivity of Dinuclear Copper(II) Complexes with Carboxylate-Rich Coordination Environments. (Holz RC, Bradshaw JM, Bennett B) Inorg Chem 1998 Mar 23;37(6):1219-1225 PMID: 11670326 10/24/2001    
  • Inhibition of the aminopeptidase from Aeromonas proteolytica by L-leucinephosphonic acid. Spectroscopic and crystallographic characterization of the transition state of peptide hydrolysis. (Stamper C, Bennett B, Edwards T, Holz RC, Ringe D, Petsko G) Biochemistry 2001 Jun 19;40(24):7035-46 PMID: 11401547 06/13/2001       60 Citations
  • Reversible dissociation of thiolate ligands from molybdenum in an enzyme of the dimethyl sulfoxide reductase family. (Bray RC, Adams B, Smith AT, Bennett B, Bailey S) Biochemistry 2000 Sep 19;39(37):11258-69 PMID: 10985771 09/14/2000       78 Citations
  • Reversible carbon monoxide binding and inhibition at the active site of the Fe-only hydrogenase. (Bennett B, Lemon BJ, Peters JW) Biochemistry 2000 Jun 27;39(25):7455-60 PMID: 10858294 06/20/2000       111 Citations
  • Dimethylsulfoxide reductase: an enzyme capable of catalysis with either molybdenum or tungsten at the active site. (Stewart LJ, Bailey S, Bennett B, Charnock JM, Garner CD, McAlpine AS) J Mol Biol 2000 Jun 09;299(3):593-600 PMID: 10835270 06/03/2000       91 Citations
  • Sulfite:Cytochrome c oxidoreductase from Thiobacillus novellus. Purification, characterization, and molecular biology of a heterodimeric member of the sulfite oxidase family. (Kappler U, Bennett B, Rethmeier J, Schwarz G, Deutzmann R, McEwan AG, Dahl C) J Biol Chem 2000 May 05;275(18):13202-12 PMID: 10788424 05/02/2000       121 Citations
  • Divalent metal binding properties of the methionyl aminopeptidase from Escherichia coli. (D'souza VM, Bennett B, Copik AJ, Holz RC) Biochemistry 2000 Apr 04;39(13):3817-26 PMID: 10736182 03/29/2000       95 Citations
  • Inhibition of the aminopeptidase from Aeromonas proteolytica by L-leucinethiol: kinetic and spectroscopic characterization of a slow, tight-binding inhibitor-enzyme complex. (Bienvenue DL, Bennett B, Holz RC) J Inorg Biochem 2000 Jan 15;78(1):43-54 PMID: 10714704 03/14/2000       26 Citations
  • Slow-binding inhibition of the aminopeptidase from Aeromonas proteolytica by peptide thiols: synthesis and spectroscopic characterization. (Huntington KM, Bienvenue DL, Wei Y, Bennett B, Holz RC, Pei D) Biochemistry 1999 Nov 23;38(47):15587-96 PMID: 10569943 11/26/1999       30 Citations
  • Inhibition of the aminopeptidase from Aeromonas proteolytica by aliphatic alcohols. Characterization of the hydrophobic substrate recognition site. (Ustynyuk L, Bennett B, Edwards T, Holz RC) Biochemistry 1999 Aug 31;38(35):11433-9 PMID: 10471294 09/02/1999       26 Citations
  • Models for molybdenum coordination during the catalytic cycle of periplasmic nitrate reductase from Paracoccus denitrificans derived from EPR and EXAFS spectroscopy. (Butler CS, Charnock JM, Bennett B, Sears HJ, Reilly AJ, Ferguson SJ, Garner CD, Lowe DJ, Thomson AJ, Berks BC, Richardson DJ) Biochemistry 1999 Jul 13;38(28):9000-12 PMID: 10413473 07/22/1999       75 Citations
  • 1-Butaneboronic acid binding to Aeromonas proteolytica aminopeptidase: a case of arrested development. (De Paola CC, Bennett B, Holz RC, Ringe D, Petsko GA) Biochemistry 1999 Jul 13;38(28):9048-53 PMID: 10413478 07/22/1999       39 Citations
  • Spectroscopically distinct cobalt(II) sites in heterodimetallic forms of the aminopeptidase from Aeromonas proteolytica: characterization of substrate binding. (Bennett B, Holz RC) Biochemistry 1997 Aug 12;36(32):9837-46 PMID: 9245416 08/12/1997       67 Citations
  • Structural investigation of the molybdenum site of the periplasmic nitrate reductase from Thiosphaera pantotropha by X-ray absorption spectroscopy. (Bennett B, Charnock JM, Sears HJ, Berks BC, Thomson AJ, Ferguson SJ, Garner CD, Richardson DJ) Biochem J 1996 Jul 15;317 ( Pt 2):557-63 PMID: 8713085 PMCID: PMC1217522 07/15/1996       15 Citations
  • Reconstitution of the [4Fe-4S] cluster in FNR and demonstration of the aerobic-anaerobic transcription switch in vitro. (Green J, Bennett B, Jordan P, Ralph ET, Thomson AJ, Guest JR) Biochem J 1996 Jun 15;316 ( Pt 3):887-92 PMID: 8670167 PMCID: PMC1217433 06/15/1996       144 Citations
  • Evidence favoring molybdenum-carbon bond formation in xanthine oxidase action: 17Q- and 13C-ENDOR and kinetic studies. (Howes BD, Bray RC, Richards RL, Turner NA, Bennett B, Lowe DJ) Biochemistry 1996 Feb 06;35(5):1432-43 PMID: 8634273 02/06/1996       74 Citations
  • Recent studies on xanthine oxidase and related enzymes. (Bray RC, Bennett B, Burke JF, Chovnick A, Doyle WA, Howes BD, Lowe DJ, Richards RL, Turner NA, Ventom A, Whittle JR) Biochem Soc Trans 1996 Feb;24(1):99-105 PMID: 8674784 02/01/1996       29 Citations
  • Spectroscopic characterisation of an aconitase (AcnA) of Escherichia coli. (Bennett B, Gruer MJ, Guest JR, Thomson AJ) Eur J Biochem 1995 Oct 01;233(1):317-26 PMID: 7588761 10/01/1995       14 Citations
  • Identification of periplasmic nitrate reductase Mo(V) EPR signals in intact cells of Paracoccus denitrificans. (Sears HJ, Bennett B, Spiro S, Thomson AJ, Richardson DJ) Biochem J 1995 Aug 15;310 ( Pt 1):311-4 PMID: 7646461 PMCID: PMC1135889 08/15/1995       19 Citations
  • Mo(V) electron paramagnetic resonance signals from the periplasmic nitrate reductase of Thiosphaera pantotropha. (Bennett B, Berks BC, Ferguson SJ, Thomson AJ, Richardson DJ) Eur J Biochem 1994 Dec 15;226(3):789-98 PMID: 7813468 12/15/1994       48 Citations
  • Multiple states of the molybdenum centre of dimethylsulphoxide reductase from Rhodobacter capsulatus revealed by EPR spectroscopy. (Bennett B, Benson N, McEwan AG, Bray RC) Eur J Biochem 1994 Oct 01;225(1):321-31 PMID: 7925452 10/01/1994       88 Citations
  • E.p.r. characterisation of the molybdenum centre of Rhodobacter capsulatus dimethylsulphoxide reductase: new signals on reduction with Na2S2O4. (Bennett B, Benson N, McEwan AG, Bray RC) Biochem Soc Trans 1994 Aug;22(3):285S PMID: 7821544 08/01/1994       6 Citations
  • Further studies on redox-related activation and deactivation of E. coli nitrate reductase: a possible physiologically relevant role for the low potential [4Fe-4S] centres. (Bennett B, Bray RC) Biochem Soc Trans 1994 Aug;22(3):283S PMID: 7821542 08/01/1994       3 Citations
  • Redox-related activation and deactivation of E. coli nitrate reductase: kinetic and spectroscopic studies. (Bennett B, Bray RC) Biochem Soc Trans 1994 Feb;22(1):78S PMID: 8206310 02/01/1994       3 Citations
  • Roles of molybdenum, FAD and iron-sulphur domains in molybdenum-containing hydroxylases: molecular genetic, kinetic and spectroscopic studies. (Hughes RK, Bennett B, Doyle WA, Burke JF, Chovnick A, Bray RC) Biochem Soc Trans 1991 Aug;19(3):260S PMID: 1783109 08/01/1991       3 Citations
  • 31P ENDOR studies of xanthine oxidase: coupling of phosphorus of the pterin cofactor to molybdenum (V). (Howes BD, Bennett B, Koppenhöfer A, Lowe DJ, Bray RC) Biochemistry 1991 Apr 23;30(16):3969-75 PMID: 1850296 04/23/1991       20 Citations
  • Last update: 11/28/2018
    jenkins-FCD Prod-299 9ef562391eceb2b8f95265c767fbba1ce5a52fd6