Medical College of Wisconsin
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Brian R. Hoffmann PhD

Brian R. Hoffmann PhD

Assistant Professor

Institution: Medical College of Wisconsin
Department: Biomedical Engineering
Program: Biomedical Engineering Program

Member of the Cardiovascular Center


  • Stone former urine proteome demonstrates a cationic shift in protein distribution compared to normal. (Kolbach-Mandel AM, Mandel NS, Hoffmann BR, Kleinman JG, Wesson JA) Urolithiasis 2017 Aug;45(4):337-346 PMID: 28314883 PMCID: PMC5511579 03/21/2017    
  • Mitochondria-regulated formation of endothelium-derived extracellular vesicles shifts the mediator of flow-induced vasodilation. (Freed JK, Durand MJ, Hoffmann BR, Densmore JC, Greene AS, Gutterman DD) Am J Physiol Heart Circ Physiol 2017 May 01;312(5):H1096-H1104 PMID: 28213406 PMCID: PMC5451582 02/19/2017       3 Citations
  • Mechanisms of Mas1 Receptor-Mediated Signaling in the Vascular Endothelium. (Hoffmann BR, Stodola TJ, Wagner JR, Didier DN, Exner EC, Lombard JH, Greene AS) Arterioscler Thromb Vasc Biol 2017 Mar;37(3):433-445 PMID: 28082260 PMCID: PMC5323371 01/14/2017       3 Citations
  • Hippocampal proteomics defines pathways associated with memory decline and resilience in normal aging and Alzheimer's disease mouse models. (Neuner SM, Wilmott LA, Hoffmann BR, Mozhui K, Kaczorowski CC) Behav Brain Res 2017 03 30;322(Pt B):288-298 PMID: 27265785 PMCID: PMC5135662 06/07/2016       12 Citations
  • Tumor Necrosis Factor α Regulates Endothelial Progenitor Cell Migration via CADM1 and NF-kB. (Prisco AR, Hoffmann BR, Kaczorowski CC, McDermott-Roe C, Stodola TJ, Exner EC, Greene AS) Stem Cells 2016 07;34(7):1922-33 PMID: 26867147 PMCID: PMC4931961 02/13/2016       5 Citations
  • Genome-wide epigenetic and proteomic analysis reveals altered Notch signaling in EPC dysfunction. (Karcher JR, Hoffmann BR, Liu P, Liu Y, Liang M, Greene AS) Physiol Rep 2015 Apr;3(4) PMID: 25921777 PMCID: PMC4425964 04/30/2015    
  • TRPC3 channels critically regulate hippocampal excitability and contextual fear memory. (Neuner SM, Wilmott LA, Hope KA, Hoffmann B, Chong JA, Abramowitz J, Birnbaumer L, O'Connell KM, Tryba AK, Greene AS, Savio Chan C, Kaczorowski CC) Behav Brain Res 2015 Mar 15;281:69-77 PMID: 25513972 PMCID: PMC4677051 12/17/2014       13 Citations
  • Automated quantification reveals hyperglycemia inhibits endothelial angiogenic function. (Prisco AR, Bukowy JD, Hoffmann BR, Karcher JR, Exner EC, Greene AS) PLoS One 2014;9(4):e94599 PMID: 24718615 PMCID: PMC3981811 04/11/2014       7 Citations
  • Targeting the endothelial progenitor cell surface proteome to identify novel mechanisms that mediate angiogenic efficacy in a rodent model of vascular disease. (Kaczorowski CC, Stodola TJ, Hoffmann BR, Prisco AR, Liu PY, Didier DN, Karcher JR, Liang M, Jacob HJ, Greene AS) Physiol Genomics 2013 Nov 01;45(21):999-1011 PMID: 24022221 PMCID: PMC3841789 09/12/2013       11 Citations
  • Vascular endothelial growth factor-A signaling in bone marrow-derived endothelial progenitor cells exposed to hypoxic stress. (Hoffmann BR, Wagner JR, Prisco AR, Janiak A, Greene AS) Physiol Genomics 2013 Nov 01;45(21):1021-34 PMID: 24022223 PMCID: PMC3841787 09/12/2013       18 Citations
  • Chemical proteomics-based analysis of off-target binding profiles for rosiglitazone and pioglitazone: clues for assessing potential for cardiotoxicity. (Hoffmann BR, El-Mansy MF, Sem DS, Greene AS) J Med Chem 2012 Oct 11;55(19):8260-71 PMID: 22970990 PMCID: PMC4113394 09/14/2012       24 Citations
  • Modification of EGF-like module 1 of thrombospondin-1, an animal extracellular protein, by O-linked N-acetylglucosamine. (Hoffmann BR, Liu Y, Mosher DF) PLoS One 2012;7(3):e32762 PMID: 22403705 PMCID: PMC3293841 03/10/2012       13 Citations
  • Reactivity of the N-terminal region of fibronectin protein to transglutaminase 2 and factor XIIIA. (Hoffmann BR, Annis DS, Mosher DF) J Biol Chem 2011 Sep 16;286(37):32220-30 PMID: 21757696 PMCID: PMC3173148 07/16/2011       19 Citations
  • iso-DGR sequences do not mediate binding of fibronectin N-terminal modules to adherent fibronectin-null fibroblasts. (Xu J, Maurer LM, Hoffmann BR, Annis DS, Mosher DF) J Biol Chem 2010 Mar 19;285(12):8563-71 PMID: 20097751 PMCID: PMC2838278 01/26/2010       17 Citations
  • The phylogenetic position of Allocreadiidae (Trematoda: Digenea) from partial sequences of the 18S and 28S ribosomal RNA genes. (Choudhury A, Rosas Valdez R, Johnson RC, Hoffmann B, Pérez-Ponce de León G) J Parasitol 2007 Feb;93(1):192-6 PMID: 17436963 04/18/2007       20 Citations
  • Last update: 06/21/2017
    jenkins-FCD Prod-299 9ef562391eceb2b8f95265c767fbba1ce5a52fd6