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David D. Gutterman MD

David D. Gutterman MD

Sr Assoc Director, Professor

Institution: Medical College of Wisconsin
Department: Medicine
Division: Cardiology
Program: Administration

Member of the Cardiovascular Center


I am willing to mentor a junior faculty member.


Research Experience

  • Angina Pectoris
  • Coronary Artery Disease
  • Coronary Circulation
  • Endothelium
  • Endothelium, Vascular
  • Endothelium-Dependent Relaxing Factors
  • Nitric Oxide
  • Reactive Oxygen Species
  • Vasodilation
  • MCW Program / Core Facilities

  • Clinical and Translational Science Institute
  • Cardiovascular Center
  • Publications

  • Treatment of Patients with Obese Type 2 Diabetes with Tantalus-DIAMOND® Gastric Electrical Stimulation: Normal Triglycerides Predict Durable Effects for at Least 3 Years. (Lebovitz HE, Ludvik B, Yaniv I, Schwartz T, Zelewski M, Gutterman DD, Metacure Investigators) Horm Metab Res 2015 Jun;47(6):456-62 PMID: 25993254
  • Acute exertion elicits a H2O2-dependent vasodilator mechanism in the microvasculature of exercise-trained but not sedentary adults. (Durand MJ, Dharmashankar K, Bian JT, Das E, Vidovich M, Gutterman DD, Phillips SA) Hypertension 2015 Jan;65(1):140-5 PMID: 25368025 PMCID: PMC4268168
  • An acute rise in intraluminal pressure shifts the mediator of flow-mediated dilation from nitric oxide to hydrogen peroxide in human arterioles. (Beyer AM, Durand MJ, Hockenberry J, Gamblin TC, Phillips SA, Gutterman DD) Am J Physiol Heart Circ Physiol 2014 Dec 1;307(11):H1587-93 PMID: 25260615 PMCID: PMC4255007
  • Ceramide changes the mediator of flow-induced vasodilation from nitric oxide to hydrogen peroxide in the human microcirculation. (Freed JK, Beyer AM, LoGiudice JA, Hockenberry JC, Gutterman DD) Circ Res 2014 Aug 15;115(5):525-32 PMID: 24920698
  • Exercise and vascular function: how much is too much? (Durand MJ, Gutterman DD) Can J Physiol Pharmacol 2014 Jul;92(7):551-7 PMID: 24873760 PMCID: PMC4398063
  • The vascular renin-angiotensin system contributes to blunted vasodilation induced by transient high pressure in human adipose microvessels. (Durand MJ, Phillips SA, Widlansky ME, Otterson MF, Gutterman DD) Am J Physiol Heart Circ Physiol 2014 Jul 1;307(1):H25-32 PMID: 24778165 PMCID: PMC4080172
  • Vascular dysfunction in diabetes mellitus: large conductance calcium-activated potassium channels as part of a subsarcolemmal signaling soiree. (Gutterman DD, Durand MJ) Circ Res 2014 Feb 14;114(4):588-90 PMID: 24526670
  • In-depth proteomic analysis of human tropomyosin by top-down mass spectrometry. (Peng Y, Yu D, Gregorich Z, Chen X, Beyer AM, Gutterman DD, Ge Y) J Muscle Res Cell Motil 2013 Aug;34(3-4):199-210 PMID: 23881156 PMCID: PMC3849107
  • A new application for CPAP in preventing atrial fibrillation. (Rubenstein JC, Gutterman DD) Chest 2013 May;143(5):1198-9 PMID: 23648900
  • Arachidonic acid-induced dilation in human coronary arterioles: convergence of signaling mechanisms on endothelial TRPV4-mediated Ca2+ entry. (Zheng X, Zinkevich NS, Gebremedhin D, Gauthier KM, Nishijima Y, Fang J, Wilcox DA, Campbell WB, Gutterman DD, Zhang DX) J Am Heart Assoc 2013 Jun;2(3):e000080 PMID: 23619744 PMCID: PMC3698766
  • The intermediate conductance calcium-activated potassium channel KCa3.1 regulates vascular smooth muscle cell proliferation via controlling calcium-dependent signaling. (Bi D, Toyama K, Lemaître V, Takai J, Fan F, Jenkins DP, Wulff H, Gutterman DD, Park F, Miura H) J Biol Chem 2013 May 31;288(22):15843-53 PMID: 23609438 PMCID: PMC3668741
  • Mitochondrial reactive oxygen species and vascular function: less is more. (Freed JK, Gutterman DD) Arterioscler Thromb Vasc Biol 2013 Apr;33(4):673-5 PMID: 23486769
  • A practical algorithmic approach to the diagnosis and management of solitary pulmonary nodules: part 2: pretest probability and algorithm. (Patel VK, Naik SK, Naidich DP, Travis WD, Weingarten JA, Lazzaro R, Gutterman DD, Wentowski C, Grosu HB, Raoof S) Chest 2013 Mar;143(3):840-6 PMID: 23460161
  • A practical algorithmic approach to the diagnosis and management of solitary pulmonary nodules: part 1: radiologic characteristics and imaging modalities. (Patel VK, Naik SK, Naidich DP, Travis WD, Weingarten JA, Lazzaro R, Gutterman DD, Wentowski C, Grosu HB, Raoof S) Chest 2013 Mar;143(3):825-39 PMID: 23460160
  • Diversity in mechanisms of endothelium-dependent vasodilation in health and disease. (Durand MJ, Gutterman DD) Microcirculation 2013 Apr;20(3):239-47 PMID: 23311975 PMCID: PMC3625248
  • Ecto-5'-nucleotidase, CD73, is an endothelium-derived hyperpolarizing factor synthase. (Ohta M, Toyama K, Gutterman DD, Campbell WB, Lemaître V, Teraoka R, Miura H) Arterioscler Thromb Vasc Biol 2013 Mar;33(3):629-36 PMID: 23288168 PMCID: PMC3587694
  • Protective role of clusterin in preserving endothelial function in AL amyloidosis. (Franco DA, Truran S, Burciu C, Gutterman DD, Maltagliati A, Weissig V, Hari P, Migrino RQ) Atherosclerosis 2012 Nov;225(1):220-3 PMID: 22981431 PMCID: PMC3478430
  • Adverse alterations in mitochondrial function contribute to type 2 diabetes mellitus-related endothelial dysfunction in humans. (Kizhakekuttu TJ, Wang J, Dharmashankar K, Ying R, Gutterman DD, Vita JA, Widlansky ME) Arterioscler Thromb Vasc Biol 2012 Oct;32(10):2531-9 PMID: 22879582 PMCID: PMC3570053
  • First, do no harm: less training ≠ quality care. (Baumann MH, Simpson SQ, Stahl M, Raoof S, Marciniuk DD, Gutterman DD, American College of Chest Physicians and the American Association of Critical-Care Nurses) Am J Crit Care 2012 Jul;21(4):227-30 PMID: 22721978
  • First, do no harm: less training ≠ quality care. (Baumann MH, Simpson SQ, Stahl M, Raoof S, Marciniuk DD, Gutterman DD, American College of Chest Physicians, American Association of Critical-Care Nurses) Chest 2012 Jul;142(1):5-7 PMID: 22700778
  • An official multi-society statement: the role of clinical research results in the practice of critical care medicine. (Tonelli MR, Curtis JR, Guntupalli KK, Rubenfeld GD, Arroliga AC, Brochard L, Douglas IS, Gutterman DD, Hall JR, Kavanagh BP, Mancebo J, Misak CJ, Simpson SQ, Slutsky AS, Suffredini AF, Thompson BT, Ware LB, Wheeler AP, Levy MM, ACCP/ATS/SCCM Working Group) Am J Respir Crit Care Med 2012 May 15;185(10):1117-24 PMID: 22589312
  • Executive summary: Antithrombotic Therapy and Prevention of Thrombosis, 9th ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines. (Guyatt GH, Akl EA, Crowther M, Gutterman DD, Schuünemann HJ, American College of Chest Physicians Antithrombotic Therapy and Prevention of Thrombosis Panel) Chest 2012 Feb;141(2 Suppl):7S-47S PMID: 22315257 PMCID: PMC3278060
  • Nitric oxide synthase-dependent vasodilation of human subcutaneous arterioles correlates with noninvasive measurements of endothelial function. (Dharmashankar K, Welsh A, Wang J, Kizhakekuttu TJ, Ying R, Gutterman DD, Widlansky ME) Am J Hypertens 2012 May;25(5):528-34 PMID: 22337207 PMCID: PMC3328603
  • Methodology for the development of antithrombotic therapy and prevention of thrombosis guidelines: Antithrombotic Therapy and Prevention of Thrombosis, 9th ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines. (Guyatt GH, Norris SL, Schulman S, Hirsh J, Eckman MH, Akl EA, Crowther M, Vandvik PO, Eikelboom JW, McDonagh MS, Lewis SZ, Gutterman DD, Cook DJ, Schünemann HJ, American College of Chest Physicians) Chest 2012 Feb;141(2 Suppl):53S-70S PMID: 22315256 PMCID: PMC3278053
  • Primary and secondary prevention of cardiovascular disease: Antithrombotic Therapy and Prevention of Thrombosis, 9th ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines. (Vandvik PO, Lincoff AM, Gore JM, Gutterman DD, Sonnenberg FA, Alonso-Coello P, Akl EA, Lansberg MG, Guyatt GH, Spencer FA, American College of Chest Physicians) Chest 2012 Feb;141(2 Suppl):e637S-68S PMID: 22315274 PMCID: PMC3278064
  • Introduction to the ninth edition: Antithrombotic Therapy and Prevention of Thrombosis, 9th ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines. (Guyatt GH, Akl EA, Crowther M, Schünemann HJ, Gutterman DD, Zelman Lewis S, American College of Chest Physicians) Chest 2012 Feb;141(2 Suppl):48S-52S PMID: 22315255 PMCID: PMC3278068
  • Acute exposure to low glucose rapidly induces endothelial dysfunction and mitochondrial oxidative stress: role for AMP kinase. (Wang J, Alexanian A, Ying R, Kizhakekuttu TJ, Dharmashankar K, Vasquez-Vivar J, Gutterman DD, Widlansky ME) Arterioscler Thromb Vasc Biol 2012 Mar;32(3):712-20 PMID: 22207730 PMCID: PMC3319449
  • H2O2-induced dilation in human coronary arterioles: role of protein kinase G dimerization and large-conductance Ca2+-activated K+ channel activation. (Zhang DX, Borbouse L, Gebremedhin D, Mendoza SA, Zinkevich NS, Li R, Gutterman DD) Circ Res 2012 Feb 3;110(3):471-80 PMID: 22158710 PMCID: PMC3272100
  • Activation of endothelial TRPV4 channels mediates flow-induced dilation in human coronary arterioles: role of Ca2+ entry and mitochondrial ROS signaling. (Bubolz AH, Mendoza SA, Zheng X, Zinkevich NS, Li R, Gutterman DD, Zhang DX) Am J Physiol Heart Circ Physiol 2012 Feb 1;302(3):H634-42 PMID: 22140047 PMCID: PMC3353785
  • Regulation of the human coronary microcirculation. (Beyer AM, Gutterman DD) J Mol Cell Cardiol 2012 Apr;52(4):814-21 PMID: 22033434 PMCID: PMC3306504
  • Human microvascular dysfunction and apoptotic injury induced by AL amyloidosis light chain proteins. (Migrino RQ, Truran S, Gutterman DD, Franco DA, Bright M, Schlundt B, Timmons M, Motta A, Phillips SA, Hari P) Am J Physiol Heart Circ Physiol 2011 Dec;301(6):H2305-12 PMID: 21963839 PMCID: PMC3233808
  • Soluble epoxide hydrolase contamination of specific catalase preparations inhibits epoxyeicosatrienoic acid vasodilation of rat renal arterioles. (Gauthier KM, Olson L, Harder A, Isbell M, Imig JD, Gutterman DD, Falck JR, Campbell WB) Am J Physiol Renal Physiol 2011 Oct;301(4):F765-72 PMID: 21753077 PMCID: PMC3191800
  • Folic acid supplementation improves vascular function in professional dancers with endothelial dysfunction. (Hoch AZ, Papanek P, Szabo A, Widlansky ME, Gutterman DD) PM R 2011 Nov;3(11):1005-12 PMID: 21715240 PMCID: PMC3328806
  • ROS-induced ROS release in vascular biology: redox-redox signaling. (Zinkevich NS, Gutterman DD) Am J Physiol Heart Circ Physiol 2011 Sep;301(3):H647-53 PMID: 21685266 PMCID: PMC3191081
  • Association between the female athlete triad and endothelial dysfunction in dancers. (Hoch AZ, Papanek P, Szabo A, Widlansky ME, Schimke JE, Gutterman DD) Clin J Sport Med 2011 Mar;21(2):119-25 PMID: 21358502 PMCID: PMC3570811
  • Resistance and aerobic exercise protects against acute endothelial impairment induced by a single exposure to hypertension during exertion. (Phillips SA, Das E, Wang J, Pritchard K, Gutterman DD) J Appl Physiol (1985) 2011 Apr;110(4):1013-20 PMID: 21252216 PMCID: PMC3075126
  • H2O2 is the transferrable factor mediating flow-induced dilation in human coronary arterioles. (Liu Y, Bubolz AH, Mendoza S, Zhang DX, Gutterman DD) Circ Res 2011 Mar 4;108(5):566-73 PMID: 21233456 PMCID: PMC3108183
  • Regulation of endothelial function by mitochondrial reactive oxygen species. (Widlansky ME, Gutterman DD) Antioxid Redox Signal 2011 Sep 15;15(6):1517-30 PMID: 21194353 PMCID: PMC3151425
  • Cigarette smoking impairs Na+-K+-ATPase activity in the human coronary microcirculation. (Miura H, Toyama K, Pratt PF, Gutterman DD) Am J Physiol Heart Circ Physiol 2011 Jan;300(1):H109-17 PMID: 21076023 PMCID: PMC3023254
  • Transient receptor potential channel activation and endothelium-dependent dilation in the systemic circulation. (Zhang DX, Gutterman DD) J Cardiovasc Pharmacol 2011 Feb;57(2):133-9 PMID: 20881603 PMCID: PMC3047599
  • Measuring FMD in the brachial artery: how important is QRS gating? (Kizhakekuttu TJ, Gutterman DD, Phillips SA, Jurva JW, Arthur EI, Das E, Widlansky ME) J Appl Physiol (1985) 2010 Oct;109(4):959-65 PMID: 20671033 PMCID: PMC2963331
  • Altered mitochondrial membrane potential, mass, and morphology in the mononuclear cells of humans with type 2 diabetes. (Widlansky ME, Wang J, Shenouda SM, Hagen TM, Smith AR, Kizhakekuttu TJ, Kluge MA, Weihrauch D, Gutterman DD, Vita JA) Transl Res 2010 Jul;156(1):15-25 PMID: 20621033 PMCID: PMC2904361
  • Resurrecting hope for antioxidant treatment of cardiovascular disease: focus on mitochondria. (O'Connor PM, Gutterman DD) Circ Res 2010 Jul 9;107(1):9-11 PMID: 20616335 PMCID: PMC2929761
  • Folic acid supplementation improves vascular function in amenorrheic runners. (Hoch AZ, Lynch SL, Jurva JW, Schimke JE, Gutterman DD) Clin J Sport Med 2010 May;20(3):205-10 PMID: 20445362
  • TRPV4-mediated endothelial Ca2+ influx and vasodilation in response to shear stress. (Mendoza SA, Fang J, Gutterman DD, Wilcox DA, Bubolz AH, Li R, Suzuki M, Zhang DX) Am J Physiol Heart Circ Physiol 2010 Feb;298(2):H466-76 PMID: 19966050 PMCID: PMC2822567
  • Prevalence of the female athlete triad in high school athletes and sedentary students. (Hoch AZ, Pajewski NM, Moraski L, Carrera GF, Wilson CR, Hoffmann RG, Schimke JE, Gutterman DD) Clin J Sport Med 2009 Sep;19(5):421-8 PMID: 19741317 PMCID: PMC2848387
  • C-reactive protein: a multipronged assailant on endothelium-dependent vasodilation. (Larsen BT, Gutterman DD) J Mol Cell Cardiol 2009 Aug;47(2):177-9 PMID: 19450604
  • Systemic and microvascular oxidative stress induced by light chain amyloidosis. (Migrino RQ, Hari P, Gutterman DD, Bright M, Truran S, Schlundt B, Phillips SA) Int J Cardiol 2010 Nov 5;145(1):67-8 PMID: 19446898 PMCID: PMC2974792
  • Protective actions of epoxyeicosatrienoic acid: dual targeting of cardiovascular PI3K and KATP channels. (Bodiga S, Zhang R, Jacobs DE, Larsen BT, Tampo A, Manthati VL, Kwok WM, Zeldin DC, Falck JR, Gutterman DD, Jacobs ER, Medhora MM) J Mol Cell Cardiol 2009 Jun;46(6):978-88 PMID: 19336274 PMCID: PMC2796716
  • Silent myocardial ischemia. (Gutterman DD) Circ J 2009 May;73(5):785-97 PMID: 19282605
  • Bradykinin-induced dilation of human coronary arterioles requires NADPH oxidase-derived reactive oxygen species. (Larsen BT, Bubolz AH, Mendoza SA, Pritchard KA Jr, Gutterman DD) Arterioscler Thromb Vasc Biol 2009 May;29(5):739-45 PMID: 19213944 PMCID: PMC2727937
  • Vascular control in humans: focus on the coronary microcirculation. (Liu Y, Gutterman DD) Basic Res Cardiol 2009 May;104(3):211-27 PMID: 19190954 PMCID: PMC3045058
  • Transient receptor potential vanilloid type 4-deficient mice exhibit impaired endothelium-dependent relaxation induced by acetylcholine in vitro and in vivo. (Zhang DX, Mendoza SA, Bubolz AH, Mizuno A, Ge ZD, Li R, Warltier DC, Suzuki M, Gutterman DD) Hypertension 2009 Mar;53(3):532-8 PMID: 19188524 PMCID: PMC2694062
  • Possible relationship of folic Acid supplementation and improved flow-mediated dilation in premenopausal, eumenorrheic athletic women. (Hoch AZ, Pajewski NM, Hoffmann RG, Schimke JE, Gutterman DD) J Sports Sci Med 2009;8(1):123-9 PMID: 24150565 PMCID: PMC3737801
  • Effects of limb electrode placement on the 12- and 16-lead electrocardiogram. (Farrell RM, Syed A, Syed A, Gutterman DD) J Electrocardiol 2008 Nov-Dec;41(6):536-45 PMID: 18790505
  • The intermediate-conductance calcium-activated potassium channel KCa3.1 contributes to atherogenesis in mice and humans. (Toyama K, Wulff H, Chandy KG, Azam P, Raman G, Saito T, Fujiwara Y, Mattson DL, Das S, Melvin JE, Pratt PF, Hatoum OA, Gutterman DD, Harder DR, Miura H) J Clin Invest 2008 Sep;118(9):3025-37 PMID: 18688283 PMCID: PMC2496961
  • Age-related attenuation of isoflurane preconditioning in human atrial cardiomyocytes: roles for mitochondrial respiration and sarcolemmal adenosine triphosphate-sensitive potassium channel activity. (Mio Y, Bienengraeber MW, Marinovic J, Gutterman DD, Rakic M, Bosnjak ZJ, Stadnicka A) Anesthesiology 2008 Apr;108(4):612-20 PMID: 18362592 PMCID: PMC2697447
  • Endothelial cytoskeletal elements are critical for flow-mediated dilation in human coronary arterioles. (Liu Y, Li H, Bubolz AH, Zhang DX, Gutterman DD) Med Biol Eng Comput 2008 May;46(5):469-78 PMID: 18340474 PMCID: PMC2702135
  • Benefit of low-fat over low-carbohydrate diet on endothelial health in obesity. (Phillips SA, Jurva JW, Syed AQ, Syed AQ, Kulinski JP, Pleuss J, Hoffmann RG, Gutterman DD) Hypertension 2008 Feb;51(2):376-82 PMID: 18195164 PMCID: PMC2702133
  • Hydrogen peroxide inhibits cytochrome p450 epoxygenases: interaction between two endothelium-derived hyperpolarizing factors. (Larsen BT, Gutterman DD, Sato A, Toyama K, Campbell WB, Zeldin DC, Manthati VL, Falck JR, Miura H) Circ Res 2008 Jan 4;102(1):59-67 PMID: 17975109 PMCID: PMC2364729
  • Athletic amenorrhea and endothelial dysfunction. (Hoch AZ, Jurva JW, Staton MA, Thielke R, Hoffmann RG, Pajewski N, Gutterman DD) WMJ 2007 Sep;106(6):301-6 PMID: 17970010
  • Epoxyeicosatrienoic acids, TRP channels, and intracellular Ca2+ in the vasculature: an endothelium-derived endothelium-hyperpolarizing factor? (Larsen BT, Zhang DX, Gutterman DD) Arterioscler Thromb Vasc Biol 2007 Dec;27(12):2496-8 PMID: 17962695
  • The female athlete triad and cardiovascular dysfunction. (Hoch AZ, Lal S, Jurva JW, Gutterman DD) Phys Med Rehabil Clin N Am 2007 Aug;18(3):385-400, vii-viii PMID: 17678758
  • Ebselen reduces nitration and restores voltage-gated potassium channel function in small coronary arteries of diabetic rats. (Bubolz AH, Wu Q, Larsen BT, Gutterman DD, Liu Y) Am J Physiol Heart Circ Physiol 2007 Oct;293(4):H2231-7 PMID: 17675568
  • The adventitia: the outs and ins of vascular disease. (Pagano PJ, Gutterman DD) Cardiovasc Res 2007 Sep 1;75(4):636-9 PMID: 17678636 PMCID: PMC3897155
  • Combating nitrate tolerance: a novel endogenous mechanism. (Gutterman DD) Arterioscler Thromb Vasc Biol 2007 Aug;27(8):1673-6 PMID: 17634519
  • Mitochondrial reactive oxygen species-mediated signaling in endothelial cells. (Zhang DX, Gutterman DD) Am J Physiol Heart Circ Physiol 2007 May;292(5):H2023-31 PMID: 17237240
  • Beyond vasodilatation: non-vasomotor roles of epoxyeicosatrienoic acids in the cardiovascular system. (Larsen BT, Campbell WB, Gutterman DD) Trends Pharmacol Sci 2007 Jan;28(1):32-8 PMID: 17150260
  • Relating cardiac performance with oxygen consumption: historical observations continue to spawn scientific discovery. (Gutterman DD, Cowley AW Jr) Am J Physiol Heart Circ Physiol 2006 Dec;291(6):H2555-6 PMID: 17090783
  • The mechanism of flow-induced dilation in human adipose arterioles involves hydrogen peroxide during CAD. (Phillips SA, Hatoum OA, Gutterman DD) Am J Physiol Heart Circ Physiol 2007 Jan;292(1):H93-100 PMID: 17040967
  • The effect of exertional hypertension evoked by weight lifting on vascular endothelial function. (Jurva JW, Phillips SA, Syed AQ, Syed AY, Pitt S, Weaver A, Gutterman DD) J Am Coll Cardiol 2006 Aug 1;48(3):588-9 PMID: 16875990
  • The coronary microcirculation in cyanotic congenital heart disease. (Dedkov EI, Perloff JK, Tomanek RJ, Fishbein MC, Gutterman DD) Circulation 2006 Jul 18;114(3):196-200 PMID: 16831984
  • Hypoxia, coronary dilation, and the pentose phosphate pathway. (Larsen BT, Gutterman DD) Am J Physiol Heart Circ Physiol 2006 Jun;290(6):H2169-71 PMID: 16687606
  • Emerging role of epoxyeicosatrienoic acids in coronary vascular function. (Larsen BT, Gutterman DD, Hatoum OA) Eur J Clin Invest 2006 May;36(5):293-300 PMID: 16634832
  • Protective effects of epoxyeicosatrienoic acids on human endothelial cells from the pulmonary and coronary vasculature. (Dhanasekaran A, Al-Saghir R, Lopez B, Zhu D, Gutterman DD, Jacobs ER, Medhora M) Am J Physiol Heart Circ Physiol 2006 Aug;291(2):H517-31 PMID: 16617127
  • American College of Chest Physicians' cough guidelines. (Irwin RS, Gutterman DD) Lancet 2006 Mar 25;367(9515):981 PMID: 16564350
  • American College of Chest Physicians evidence-based guidelines--the next generation: considering resource use and evolution to a single grading system. (Baumann MH, Gutterman DD) Chest 2006 Jan;129(1):10-2 PMID: 16424406
  • Radiation induces endothelial dysfunction in murine intestinal arterioles via enhanced production of reactive oxygen species. (Hatoum OA, Otterson MF, Kopelman D, Miura H, Sukhotnik I, Larsen BT, Selle RM, Moulder JE, Gutterman DD) Arterioscler Thromb Vasc Biol 2006 Feb;26(2):287-94 PMID: 16322529
  • Epoxyeicosatrienoic and dihydroxyeicosatrienoic acids dilate human coronary arterioles via BK(Ca) channels: implications for soluble epoxide hydrolase inhibition. (Larsen BT, Miura H, Hatoum OA, Campbell WB, Hammock BD, Zeldin DC, Falck JR, Gutterman DD) Am J Physiol Heart Circ Physiol 2006 Feb;290(2):H491-9 PMID: 16258029 PMCID: PMC1456013
  • Paradox of simultaneous intestinal ischaemia and hyperaemia in inflammatory bowel disease. (Hatoum OA, Binion DG, Gutterman DD) Eur J Clin Invest 2005 Oct;35(10):599-609 PMID: 16178878
  • Anticoagulation: American College of Chest Physicians guidelines for the prevention and management of postoperative atrial fibrillation after cardiac surgery. (Epstein AE, Alexander JC, Gutterman DD, Maisel W, Wharton JM, American College of Chest Physicians) Chest 2005 Aug;128(2 Suppl):24S-27S PMID: 16167661
  • Epidemiology, mechanisms, and risks: American College of Chest Physicians guidelines for the prevention and management of postoperative atrial fibrillation after cardiac surgery. (Hogue CW Jr, Creswell LL, Gutterman DD, Fleisher LA, American College of Chest Physicians) Chest 2005 Aug;128(2 Suppl):9S-16S PMID: 16167659
  • Peroxynitrite reduces the endothelium-derived hyperpolarizing factor component of coronary flow-mediated dilation in PECAM-1-knockout mice. (Liu Y, Bubolz AH, Shi Y, Newman PJ, Newman DK, Gutterman DD) Am J Physiol Regul Integr Comp Physiol 2006 Jan;290(1):R57-65 PMID: 16166207
  • Novel mechanism of vasodilation in inflammatory bowel disease. (Hatoum OA, Gauthier KM, Binion DG, Miura H, Telford G, Otterson MF, Campbell WB, Gutterman DD) Arterioscler Thromb Vasc Biol 2005 Nov;25(11):2355-61 PMID: 16141408
  • Radiation induced small bowel "web" formation is associated with acquired microvascular dysfunction. (Hatoum OA, Binion DG, Phillips SA, O'Loughlin C, Komorowski RA, Gutterman DD, Otterson MF) Gut 2005 Dec;54(12):1797-800 PMID: 16127018 PMCID: PMC1774807
  • Mitochondria and reactive oxygen species: an evolution in function. (Gutterman DD) Circ Res 2005 Aug 19;97(4):302-4 PMID: 16109924
  • Mechanism of vasodilation to adenosine in coronary arterioles from patients with heart disease. (Sato A, Terata K, Miura H, Toyama K, Loberiza FR Jr, Hatoum OA, Saito T, Sakuma I, Gutterman DD) Am J Physiol Heart Circ Physiol 2005 Apr;288(4):H1633-40 PMID: 15772334
  • Redox modulation of vascular tone: focus of potassium channel mechanisms of dilation. (Gutterman DD, Miura H, Liu Y) Arterioscler Thromb Vasc Biol 2005 Apr;25(4):671-8 PMID: 15705931
  • Role of hydrogen peroxide in ACh-induced dilation of human submucosal intestinal microvessels. (Hatoum OA, Binion DG, Miura H, Telford G, Otterson MF, Gutterman DD) Am J Physiol Heart Circ Physiol 2005 Jan;288(1):H48-54 PMID: 15345486
  • Nitration and functional loss of voltage-gated K+ channels in rat coronary microvessels exposed to high glucose. (Li H, Gutterman DD, Rusch NJ, Bubolz A, Liu Y) Diabetes 2004 Sep;53(9):2436-42 PMID: 15331556
  • Coronary vasospasm and the regulation of coronary blood flow. (Konidala S, Gutterman DD) Prog Cardiovasc Dis 2004 Jan-Feb;46(4):349-73 PMID: 14961457
  • Mechanism of dilation to reactive oxygen species in human coronary arterioles. (Sato A, Sakuma I, Gutterman DD) Am J Physiol Heart Circ Physiol 2003 Dec;285(6):H2345-54 PMID: 14613909
  • Coronary vascular dysfunction associated with direct current shock injury. (Oltman CL, Clark CB, Kane NL, Zhang Y, Gutterman DD, Dellsperger KC, Kerber RE) Basic Res Cardiol 2003 Nov;98(6):406-15 PMID: 14556086
  • Mitochondrial sources of H2O2 generation play a key role in flow-mediated dilation in human coronary resistance arteries. (Liu Y, Zhao H, Li H, Kalyanaraman B, Nicolosi AC, Gutterman DD) Circ Res 2003 Sep 19;93(6):573-80 PMID: 12919951
  • Acquired microvascular dysfunction in inflammatory bowel disease: Loss of nitric oxide-mediated vasodilation. (Hatoum OA, Binion DG, Otterson MF, Gutterman DD) Gastroenterology 2003 Jul;125(1):58-69 PMID: 12851871
  • Enhancement of antral contractions and vagal afferent signaling with synchronized electrical stimulation. (Peles S, Petersen J, Aviv R, Policker S, Abu-Hatoum O, Ben-Haim SA, Gutterman DD, Sengupta JN) Am J Physiol Gastrointest Liver Physiol 2003 Sep;285(3):G577-85 PMID: 12801883
  • Elevated glucose impairs cAMP-mediated dilation by reducing Kv channel activity in rat small coronary smooth muscle cells. (Li H, Chai Q, Gutterman DD, Liu Y) Am J Physiol Heart Circ Physiol 2003 Sep;285(3):H1213-9 PMID: 12763748
  • L-4F, an apolipoprotein A-1 mimetic, dramatically improves vasodilation in hypercholesterolemia and sickle cell disease. (Ou J, Ou Z, Jones DW, Holzhauer S, Hatoum OA, Ackerman AW, Weihrauch DW, Gutterman DD, Guice K, Oldham KT, Hillery CA, Pritchard KA Jr) Circulation 2003 May 13;107(18):2337-41 PMID: 12732610
  • Is there an association between athletic amenorrhea and endothelial cell dysfunction? (Zeni Hoch A, Dempsey RL, Carrera GF, Wilson CR, Chen EH, Barnabei VM, Sandford PR, Ryan TA, Gutterman DD) Med Sci Sports Exerc 2003 Mar;35(3):377-83 PMID: 12618566
  • Mechanism of thrombin-induced vasodilation in human coronary arterioles. (Bosnjak JJ, Terata K, Miura H, Sato A, Nicolosi AC, McDonald M, Manthei SA, Saito T, Hatoum OA, Gutterman DD) Am J Physiol Heart Circ Physiol 2003 Apr;284(4):H1080-6 PMID: 12595282
  • Role for hydrogen peroxide in flow-induced dilation of human coronary arterioles. (Miura H, Bosnjak JJ, Ning G, Saito T, Miura M, Gutterman DD) Circ Res 2003 Feb 7;92(2):e31-40 PMID: 12574154
  • Diabetes mellitus impairs vasodilation to hypoxia in human coronary arterioles: reduced activity of ATP-sensitive potassium channels. (Miura H, Wachtel RE, Loberiza FR Jr, Saito T, Miura M, Nicolosi AC, Gutterman DD) Circ Res 2003 Feb 7;92(2):151-8 PMID: 12574142
  • The association of hypertension and secondary cardiovascular disease with sleep-disordered breathing. (Dart RA, Gregoire JR, Gutterman DD, Woolf SH) Chest 2003 Jan;123(1):244-60 PMID: 12527627
  • Peroxynitrite inhibits Ca2+-activated K+ channel activity in smooth muscle of human coronary arterioles. (Liu Y, Terata K, Chai Q, Li H, Kleinman LH, Gutterman DD) Circ Res 2002 Nov 29;91(11):1070-6 PMID: 12456494
  • The coronary circulation in diabetes: influence of reactive oxygen species on K+ channel-mediated vasodilation. (Liu Y, Gutterman DD) Vascul Pharmacol 2002 Jan;38(1):43-9 PMID: 12378822
  • Effect of gender on endothelium-dependent dilation to bradykinin in human adipose microvessels. (Sato A, Miura H, Liu Y, Somberg LB, Otterson MF, Demeure MJ, Schulte WJ, Eberhardt LM, Loberiza FR, Sakuma I, Gutterman DD) Am J Physiol Heart Circ Physiol 2002 Sep;283(3):H845-52 PMID: 12181110
  • Oxidative stress and potassium channel function. (Liu Y, Gutterman DD) Clin Exp Pharmacol Physiol 2002 Apr;29(4):305-11 PMID: 11985541
  • Vascular dysfunction in hyperglycemia: is protein kinase C the culprit? (Gutterman DD) Circ Res 2002 Jan 11;90(1):5-7 PMID: 11786509
  • Calcium-activated potassium channels mask vascular dysfunction associated with oxidized LDL exposure in rabbit aorta. (Bocker JM, Miller FJ, Oltman CL, Chappell DA, Gutterman DD) Jpn Heart J 2001 May;42(3):317-26 PMID: 11605770
  • High glucose impairs voltage-gated K(+) channel current in rat small coronary arteries. (Liu Y, Terata K, Rusch NJ, Gutterman DD) Circ Res 2001 Jul 20;89(2):146-52 PMID: 11463721
  • Ouabain-induced coronary vasoconstriction in cats is not neurally mediated. (Nair BA, Murad YZ, Brody MJ, Gutterman DD) Clin Exp Pharmacol Physiol 2001 Jul;28(7):510-7 PMID: 11422216
  • Flow-induced dilation of human coronary arterioles: important role of Ca(2+)-activated K(+) channels. (Miura H, Wachtel RE, Liu Y, Loberiza FR Jr, Saito T, Miura M, Gutterman DD) Circulation 2001 Apr 17;103(15):1992-8 PMID: 11306529
  • Human coronary arteriolar dilation to adrenomedullin: role of nitric oxide and K(+) channels. (Terata K, Miura H, Liu Y, Loberiza F, Gutterman DD) Am J Physiol Heart Circ Physiol 2000 Dec;279(6):H2620-6 PMID: 11087213
  • Prologue: new insights into the regulation of the coronary microcirculation. (Chilian WM, Gutterman DD) Am J Physiol Heart Circ Physiol 2000 Dec;279(6):H2585-6 PMID: 11087207
  • Impaired dilation of coronary arterioles during increases in myocardial O(2) consumption with hyperglycemia. (Ammar RF Jr, Gutterman DD, Brooks LA, Dellsperger KC) Am J Physiol Endocrinol Metab 2000 Oct;279(4):E868-74 PMID: 11001770
  • Free radicals mediate endothelial dysfunction of coronary arterioles in diabetes. (Ammar RF Jr, Gutterman DD, Brooks LA, Dellsperger KC) Cardiovasc Res 2000 Aug 18;47(3):595-601 PMID: 10963732
  • Mechanism of coronary vasodilation to insulin and insulin-like growth factor I is dependent on vessel size. (Oltman CL, Kane NL, Gutterman DD, Bar RS, Dellsperger KC) Am J Physiol Endocrinol Metab 2000 Jul;279(1):E176-81 PMID: 10893337
  • Acetylcholine-induced arteriolar dilation is reduced in streptozotocin-induced diabetic rats with motor nerve dysfunction. (Terata K, Coppey LJ, Davidson EP, Dunlap JA, Gutterman DD, Yorek MA) Br J Pharmacol 1999 Oct;128(3):837-43 PMID: 10516670 PMCID: PMC1571695
  • Adventitia-dependent influences on vascular function. (Gutterman DD) Am J Physiol 1999 Oct;277(4 Pt 2):H1265-72 PMID: 10516160
  • Human coronary arteriolar dilation to bradykinin depends on membrane hyperpolarization: contribution of nitric oxide and Ca2+-activated K+ channels. (Miura H, Liu Y, Gutterman DD) Circulation 1999 Jun 22;99(24):3132-8 PMID: 10377076
  • Pharmacologic activation of the human coronary microcirculation in vitro: endothelium-dependent dilation and differential responses to acetylcholine. (Miller FJ Jr, Dellsperger KC, Gutterman DD) Cardiovasc Res 1998 Jun;38(3):744-50 PMID: 9747443
  • Human coronary arteriolar dilation to arachidonic acid depends on cytochrome P-450 monooxygenase and Ca2+-activated K+ channels. (Miura H, Gutterman DD) Circ Res 1998 Sep 7;83(5):501-7 PMID: 9734472
  • Attenuation of ischemia-induced activation of cardiac sympathetic afferents following brief myocardial ischemia in cats. (Abe T, Morgan D, Sengupta JN, Gebhart GF, Gutterman DD) J Auton Nerv Syst 1998 Jun 30;71(1):28-36 PMID: 9722192
  • Superoxide production in vascular smooth muscle contributes to oxidative stress and impaired relaxation in atherosclerosis. (Miller FJ Jr, Gutterman DD, Rios CD, Heistad DD, Davidson BL) Circ Res 1998 Jun 29;82(12):1298-305 PMID: 9648726
  • Thoracic spinal neuron responses to repeated myocardial ischemia and epicardial bradykinin. (Gutterman DD, Pardubsky PD, Pettersen M, Marcus ML, Gebhart GF) Brain Res 1998 Apr 20;790(1-2):293-303 PMID: 9593951
  • Oxygen-derived free radicals contribute to neural stunning in the canine heart. (Miura H, Morgan DA, Gutterman DD) Am J Physiol 1997 Sep;273(3 Pt 2):H1569-75 PMID: 9321851
  • Myogenic constriction of human coronary arterioles. (Miller FJ Jr, Dellsperger KC, Gutterman DD) Am J Physiol 1997 Jul;273(1 Pt 2):H257-64 PMID: 9249498
  • Effects of glycosylated hemoglobin on vascular responses in vitro. (Oltman CL, Gutterman DD, Scott EC, Bocker JM, Dellsperger KC) Cardiovasc Res 1997 Apr;34(1):179-84 PMID: 9217888
  • Protective role of nerve growth factor against postischemic dysfunction of sympathetic coronary innervation. (Abe T, Morgan DA, Gutterman DD) Circulation 1997 Jan 7;95(1):213-20 PMID: 8994439
  • Role of adenosine receptor subtypes in neural stunning of sympathetic coronary innervation. (Abe T, Morgan DA, Gutterman DD) Am J Physiol 1997 Jan;272(1 Pt 2):H25-34 PMID: 9038919
  • Role of parabrachial nucleus in baroreflex-mediated coronary vasoconstriction. (Gutterman DD, Goodson A) Am J Physiol 1996 Sep;271(3 Pt 2):H1079-86 PMID: 8853344
  • Pheochromocytoma with reversible focal cardiac dysfunction. (Scott IU, Gutterman DD) Am Heart J 1995 Oct;130(4):909-11 PMID: 7572605
  • Transmural regulation of myocardial perfusion by neuropeptide Y. (Gutterman DD, Morgan DA) Basic Res Cardiol 1995 Jul-Aug;90(4):348-55 PMID: 8534260
  • Use of an indwelling catheter for examining cardiovascular responses to pericardial administration of bradykinin in rat. (McDermott DA, Meller ST, Gebhart GF, Gutterman DD) Cardiovasc Res 1995 Jul;30(1):39-46 PMID: 7553722
  • Role of adenosine in postischemic dysfunction of coronary innervation. (Pettersen MD, Abe T, Morgan DA, Gutterman DD) Circ Res 1995 Jan;76(1):95-101 PMID: 8001282
  • Inhibition of nitric oxide synthesis augments centrally induced sympathetic coronary vasoconstriction in cats. (Goodson AR, Leibold JM, Gutterman DD) Am J Physiol 1994 Oct;267(4 Pt 2):H1272-8 PMID: 7943371
  • Detection of cardioembolic sources with echocardiography. (Lindower PD, Gutterman DD) Compr Ther 1994;20(3):174-80 PMID: 8187459
  • Coronary vasoconstrictor pathway from anterior hypothalamus includes neurons in RVLM. (Goodson AR, LaMaster TS, Gutterman DD) Am J Physiol 1993 Dec;265(6 Pt 2):R1311-7 PMID: 8285271
  • Use of echocardiography in detecting cardiac sources of embolus. (Gutterman DD, Ayres RW) Echocardiography 1993 May;10(3):311-20 PMID: 10148638
  • Coronary vascular response to the cerebral ischemia reflex. (De Boel SL, Gutterman DD) Hypertension 1993 Feb;21(2):216-21 PMID: 8428783
  • Prediction of immediate ventricular arrhythmias after coronary artery ligation. (Ben-Haim SA, Becker B, Gutterman DD, Edoute Y, Kaplinsky E, Palti Y) J Am Coll Cardiol 1992 Nov 1;20(5):1270-6 PMID: 1401631
  • Effect of brief myocardial ischemia on sympathetic coronary vasoconstriction. (Gutterman DD, Morgan DA, Miller FJ) Circ Res 1992 Oct;71(4):960-9 PMID: 1516166
  • Patterns of hemodynamic responses associated with central activation of coronary vasoconstriction. (Jones LF, Gutterman DD, Brody MJ) Am J Physiol 1992 Feb;262(2 Pt 2):R276-83 PMID: 1539736
  • Activation in the region of parabrachial nucleus elicits neurogenically mediated coronary vasoconstriction. (Miller FJ Jr, Marcus ML, Brody MJ, Gutterman DD) Am J Physiol 1991 Nov;261(5 Pt 2):H1585-96 PMID: 1683174
  • Role of medullary lateral reticular formation in baroreflex coronary vasoconstriction. (Gutterman DD, Arthur JM, Pardubsky PD, Gebhart GF, Marcus ML, Brody MJ) Brain Res 1991 Aug 23;557(1-2):202-9 PMID: 1660752
  • Coronary vasoconstriction during stimulation in hypothalamic defense region. (Arthur JM, Bonham AC, Gutterman DD, Gebhart GF, Marcus ML, Brody MJ) Am J Physiol 1991 Feb;260(2 Pt 2):R335-45 PMID: 1996721
  • Connections between hypothalamus and medullary reticular formation mediate coronary vasoconstriction. (Gutterman DD, Bonham AC, Gebhart GF, Marcus ML, Brody MJ) Am J Physiol 1990 Sep;259(3 Pt 2):H917-24 PMID: 2396696
  • Characterization of coronary vasoconstrictor site in medullary reticular formation. (Gutterman DD, Bonham AC, Arthur JM, Gebhart GF, Marcus ML, Brody MJ) Am J Physiol 1989 Apr;256(4 Pt 2):H1218-27 PMID: 2565092
  • Characterization of the acute left ventricular thrombus: hermit or nomad? (Gutterman DD) J Am Coll Cardiol 1989 Mar 1;13(3):565-6 PMID: 2918161
  • Neurogenic regulation of coronary blood flow: evidence for a central nervous system pathway. (Bonham AC, Gutterman DD, Arthur JM, Marcus ML, Gebhart GF, Brody MJ) Circ Res 1987 Nov;61(5 Pt 2):II42-6 PMID: 2444359
  • Electrical stimulation in perifornical lateral hypothalamus decreases coronary blood flow in cats. (Bonham AC, Gutterman DD, Arthur JM, Marcus ML, Gebhart GF, Brody MJ) Am J Physiol 1987 Mar;252(3 Pt 2):H474-84 PMID: 2881488
  • Failure of pyruvate to salvage myocardium after prolonged ischemia. (Gutterman DD, Chilian WM, Eastham CL, Inou T, White CW, Marcus ML) Am J Physiol 1986 Jan;250(1 Pt 2):H114-20 PMID: 3942230
  • Differential reactivity to 5-hydroxytryptamine in canine coronary arteries. (Gutterman DD, Rusch NJ, Hermsmeyer K, Dole WP) Blood Vessels 1986;23(4-5):165-72 PMID: 3779106
  • Last update: 07/16/2015