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David D. Gutterman MD

David D. Gutterman MD

Sr Assoc Director, Professor

Institution: Medical College of Wisconsin
Department: Medicine
Division: Cardiology
Program: Administration

Member of the Cardiovascular Center


I am willing to mentor a junior faculty member.


Research Experience

  • Angina Pectoris
  • Coronary Artery Disease
  • Coronary Circulation
  • Endothelium
  • Endothelium, Vascular
  • Endothelium-Dependent Relaxing Factors
  • Nitric Oxide
  • Reactive Oxygen Species
  • Vasodilation
  • MCW Program / Core Facilities

  • Clinical and Translational Science Institute
  • Cardiovascular Center
  • Publications

  • Treatment of Patients with Obese Type 2 Diabetes with Tantalus-DIAMOND® Gastric Electrical Stimulation: Normal Triglycerides Predict Durable Effects for at Least 3 Years. (Lebovitz HE, Ludvik B, Yaniv I, Schwartz T, Zelewski M, Gutterman DD, Metacure Investigators) Horm Metab Res 2015 Jun;47(6):456-62 PMID: 25993254 05/21/2015
  • Acute exertion elicits a H2O2-dependent vasodilator mechanism in the microvasculature of exercise-trained but not sedentary adults. (Durand MJ, Dharmashankar K, Bian JT, Das E, Vidovich M, Gutterman DD, Phillips SA) Hypertension 2015 Jan;65(1):140-5 PMID: 25368025 PMCID: PMC4268168 11/05/2014
  • An acute rise in intraluminal pressure shifts the mediator of flow-mediated dilation from nitric oxide to hydrogen peroxide in human arterioles. (Beyer AM, Durand MJ, Hockenberry J, Gamblin TC, Phillips SA, Gutterman DD) Am J Physiol Heart Circ Physiol 2014 Dec 1;307(11):H1587-93 PMID: 25260615 PMCID: PMC4255007 09/28/2014
  • Ceramide changes the mediator of flow-induced vasodilation from nitric oxide to hydrogen peroxide in the human microcirculation. (Freed JK, Beyer AM, LoGiudice JA, Hockenberry JC, Gutterman DD) Circ Res 2014 Aug 15;115(5):525-32 PMID: 24920698 06/13/2014
  • Exercise and vascular function: how much is too much? (Durand MJ, Gutterman DD) Can J Physiol Pharmacol 2014 Jul;92(7):551-7 PMID: 24873760 PMCID: PMC4398063 05/31/2014
  • The vascular renin-angiotensin system contributes to blunted vasodilation induced by transient high pressure in human adipose microvessels. (Durand MJ, Phillips SA, Widlansky ME, Otterson MF, Gutterman DD) Am J Physiol Heart Circ Physiol 2014 Jul 1;307(1):H25-32 PMID: 24778165 PMCID: PMC4080172 04/30/2014
  • Vascular dysfunction in diabetes mellitus: large conductance calcium-activated potassium channels as part of a subsarcolemmal signaling soiree. (Gutterman DD, Durand MJ) Circ Res 2014 Feb 14;114(4):588-90 PMID: 24526670 02/15/2014
  • In-depth proteomic analysis of human tropomyosin by top-down mass spectrometry. (Peng Y, Yu D, Gregorich Z, Chen X, Beyer AM, Gutterman DD, Ge Y) J Muscle Res Cell Motil 2013 Aug;34(3-4):199-210 PMID: 23881156 PMCID: PMC3849107 07/25/2013
  • A new application for CPAP in preventing atrial fibrillation. (Rubenstein JC, Gutterman DD) Chest 2013 May;143(5):1198-9 PMID: 23648900 05/08/2013
  • Arachidonic acid-induced dilation in human coronary arterioles: convergence of signaling mechanisms on endothelial TRPV4-mediated Ca2+ entry. (Zheng X, Zinkevich NS, Gebremedhin D, Gauthier KM, Nishijima Y, Fang J, Wilcox DA, Campbell WB, Gutterman DD, Zhang DX) J Am Heart Assoc 2013 Jun;2(3):e000080 PMID: 23619744 PMCID: PMC3698766 04/27/2013
  • The intermediate conductance calcium-activated potassium channel KCa3.1 regulates vascular smooth muscle cell proliferation via controlling calcium-dependent signaling. (Bi D, Toyama K, Lemaître V, Takai J, Fan F, Jenkins DP, Wulff H, Gutterman DD, Park F, Miura H) J Biol Chem 2013 May 31;288(22):15843-53 PMID: 23609438 PMCID: PMC3668741 04/24/2013
  • Mitochondrial reactive oxygen species and vascular function: less is more. (Freed JK, Gutterman DD) Arterioscler Thromb Vasc Biol 2013 Apr;33(4):673-5 PMID: 23486769 03/15/2013
  • A practical algorithmic approach to the diagnosis and management of solitary pulmonary nodules: part 2: pretest probability and algorithm. (Patel VK, Naik SK, Naidich DP, Travis WD, Weingarten JA, Lazzaro R, Gutterman DD, Wentowski C, Grosu HB, Raoof S) Chest 2013 Mar;143(3):840-6 PMID: 23460161 03/06/2013
  • A practical algorithmic approach to the diagnosis and management of solitary pulmonary nodules: part 1: radiologic characteristics and imaging modalities. (Patel VK, Naik SK, Naidich DP, Travis WD, Weingarten JA, Lazzaro R, Gutterman DD, Wentowski C, Grosu HB, Raoof S) Chest 2013 Mar;143(3):825-39 PMID: 23460160 03/06/2013
  • Diversity in mechanisms of endothelium-dependent vasodilation in health and disease. (Durand MJ, Gutterman DD) Microcirculation 2013 Apr;20(3):239-47 PMID: 23311975 PMCID: PMC3625248 01/15/2013
  • Ecto-5'-nucleotidase, CD73, is an endothelium-derived hyperpolarizing factor synthase. (Ohta M, Toyama K, Gutterman DD, Campbell WB, Lemaître V, Teraoka R, Miura H) Arterioscler Thromb Vasc Biol 2013 Mar;33(3):629-36 PMID: 23288168 PMCID: PMC3587694 01/05/2013
  • Protective role of clusterin in preserving endothelial function in AL amyloidosis. (Franco DA, Truran S, Burciu C, Gutterman DD, Maltagliati A, Weissig V, Hari P, Migrino RQ) Atherosclerosis 2012 Nov;225(1):220-3 PMID: 22981431 PMCID: PMC3478430 09/18/2012
  • Adverse alterations in mitochondrial function contribute to type 2 diabetes mellitus-related endothelial dysfunction in humans. (Kizhakekuttu TJ, Wang J, Dharmashankar K, Ying R, Gutterman DD, Vita JA, Widlansky ME) Arterioscler Thromb Vasc Biol 2012 Oct;32(10):2531-9 PMID: 22879582 PMCID: PMC3570053 08/11/2012
  • First, do no harm: less training ≠ quality care. (Baumann MH, Simpson SQ, Stahl M, Raoof S, Marciniuk DD, Gutterman DD, American College of Chest Physicians and the American Association of Critical-Care Nurses) Am J Crit Care 2012 Jul;21(4):227-30 PMID: 22721978 06/23/2012
  • First, do no harm: less training ≠ quality care. (Baumann MH, Simpson SQ, Stahl M, Raoof S, Marciniuk DD, Gutterman DD, American College of Chest Physicians, American Association of Critical-Care Nurses) Chest 2012 Jul;142(1):5-7 PMID: 22700778 06/16/2012
  • An official multi-society statement: the role of clinical research results in the practice of critical care medicine. (Tonelli MR, Curtis JR, Guntupalli KK, Rubenfeld GD, Arroliga AC, Brochard L, Douglas IS, Gutterman DD, Hall JR, Kavanagh BP, Mancebo J, Misak CJ, Simpson SQ, Slutsky AS, Suffredini AF, Thompson BT, Ware LB, Wheeler AP, Levy MM, ACCP/ATS/SCCM Working Group) Am J Respir Crit Care Med 2012 May 15;185(10):1117-24 PMID: 22589312 05/17/2012
  • Executive summary: Antithrombotic Therapy and Prevention of Thrombosis, 9th ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines. (Guyatt GH, Akl EA, Crowther M, Gutterman DD, Schuünemann HJ, American College of Chest Physicians Antithrombotic Therapy and Prevention of Thrombosis Panel) Chest 2012 Feb;141(2 Suppl):7S-47S PMID: 22315257 PMCID: PMC3278060 03/15/2012
  • Nitric oxide synthase-dependent vasodilation of human subcutaneous arterioles correlates with noninvasive measurements of endothelial function. (Dharmashankar K, Welsh A, Wang J, Kizhakekuttu TJ, Ying R, Gutterman DD, Widlansky ME) Am J Hypertens 2012 May;25(5):528-34 PMID: 22337207 PMCID: PMC3328603 02/18/2012
  • Methodology for the development of antithrombotic therapy and prevention of thrombosis guidelines: Antithrombotic Therapy and Prevention of Thrombosis, 9th ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines. (Guyatt GH, Norris SL, Schulman S, Hirsh J, Eckman MH, Akl EA, Crowther M, Vandvik PO, Eikelboom JW, McDonagh MS, Lewis SZ, Gutterman DD, Cook DJ, Schünemann HJ, American College of Chest Physicians) Chest 2012 Feb;141(2 Suppl):53S-70S PMID: 22315256 PMCID: PMC3278053 02/15/2012
  • Primary and secondary prevention of cardiovascular disease: Antithrombotic Therapy and Prevention of Thrombosis, 9th ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines. (Vandvik PO, Lincoff AM, Gore JM, Gutterman DD, Sonnenberg FA, Alonso-Coello P, Akl EA, Lansberg MG, Guyatt GH, Spencer FA, American College of Chest Physicians) Chest 2012 Feb;141(2 Suppl):e637S-68S PMID: 22315274 PMCID: PMC3278064 02/15/2012
  • Introduction to the ninth edition: Antithrombotic Therapy and Prevention of Thrombosis, 9th ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines. (Guyatt GH, Akl EA, Crowther M, Schünemann HJ, Gutterman DD, Zelman Lewis S, American College of Chest Physicians) Chest 2012 Feb;141(2 Suppl):48S-52S PMID: 22315255 PMCID: PMC3278068 02/15/2012
  • Acute exposure to low glucose rapidly induces endothelial dysfunction and mitochondrial oxidative stress: role for AMP kinase. (Wang J, Alexanian A, Ying R, Kizhakekuttu TJ, Dharmashankar K, Vasquez-Vivar J, Gutterman DD, Widlansky ME) Arterioscler Thromb Vasc Biol 2012 Mar;32(3):712-20 PMID: 22207730 PMCID: PMC3319449 12/31/2011
  • H2O2-induced dilation in human coronary arterioles: role of protein kinase G dimerization and large-conductance Ca2+-activated K+ channel activation. (Zhang DX, Borbouse L, Gebremedhin D, Mendoza SA, Zinkevich NS, Li R, Gutterman DD) Circ Res 2012 Feb 3;110(3):471-80 PMID: 22158710 PMCID: PMC3272100 12/14/2011
  • Activation of endothelial TRPV4 channels mediates flow-induced dilation in human coronary arterioles: role of Ca2+ entry and mitochondrial ROS signaling. (Bubolz AH, Mendoza SA, Zheng X, Zinkevich NS, Li R, Gutterman DD, Zhang DX) Am J Physiol Heart Circ Physiol 2012 Feb 1;302(3):H634-42 PMID: 22140047 PMCID: PMC3353785 12/06/2011
  • Regulation of the human coronary microcirculation. (Beyer AM, Gutterman DD) J Mol Cell Cardiol 2012 Apr;52(4):814-21 PMID: 22033434 PMCID: PMC3306504 10/29/2011
  • Human microvascular dysfunction and apoptotic injury induced by AL amyloidosis light chain proteins. (Migrino RQ, Truran S, Gutterman DD, Franco DA, Bright M, Schlundt B, Timmons M, Motta A, Phillips SA, Hari P) Am J Physiol Heart Circ Physiol 2011 Dec;301(6):H2305-12 PMID: 21963839 PMCID: PMC3233808 10/04/2011
  • Soluble epoxide hydrolase contamination of specific catalase preparations inhibits epoxyeicosatrienoic acid vasodilation of rat renal arterioles. (Gauthier KM, Olson L, Harder A, Isbell M, Imig JD, Gutterman DD, Falck JR, Campbell WB) Am J Physiol Renal Physiol 2011 Oct;301(4):F765-72 PMID: 21753077 PMCID: PMC3191800 07/15/2011
  • Folic acid supplementation improves vascular function in professional dancers with endothelial dysfunction. (Hoch AZ, Papanek P, Szabo A, Widlansky ME, Gutterman DD) PM R 2011 Nov;3(11):1005-12 PMID: 21715240 PMCID: PMC3328806 07/01/2011
  • ROS-induced ROS release in vascular biology: redox-redox signaling. (Zinkevich NS, Gutterman DD) Am J Physiol Heart Circ Physiol 2011 Sep;301(3):H647-53 PMID: 21685266 PMCID: PMC3191081 06/21/2011
  • Association between the female athlete triad and endothelial dysfunction in dancers. (Hoch AZ, Papanek P, Szabo A, Widlansky ME, Schimke JE, Gutterman DD) Clin J Sport Med 2011 Mar;21(2):119-25 PMID: 21358502 PMCID: PMC3570811 03/02/2011
  • Resistance and aerobic exercise protects against acute endothelial impairment induced by a single exposure to hypertension during exertion. (Phillips SA, Das E, Wang J, Pritchard K, Gutterman DD) J Appl Physiol (1985) 2011 Apr;110(4):1013-20 PMID: 21252216 PMCID: PMC3075126 01/22/2011
  • H2O2 is the transferrable factor mediating flow-induced dilation in human coronary arterioles. (Liu Y, Bubolz AH, Mendoza S, Zhang DX, Gutterman DD) Circ Res 2011 Mar 4;108(5):566-73 PMID: 21233456 PMCID: PMC3108183 01/15/2011
  • Regulation of endothelial function by mitochondrial reactive oxygen species. (Widlansky ME, Gutterman DD) Antioxid Redox Signal 2011 Sep 15;15(6):1517-30 PMID: 21194353 PMCID: PMC3151425 01/05/2011
  • Cigarette smoking impairs Na+-K+-ATPase activity in the human coronary microcirculation. (Miura H, Toyama K, Pratt PF, Gutterman DD) Am J Physiol Heart Circ Physiol 2011 Jan;300(1):H109-17 PMID: 21076023 PMCID: PMC3023254 11/16/2010
  • Transient receptor potential channel activation and endothelium-dependent dilation in the systemic circulation. (Zhang DX, Gutterman DD) J Cardiovasc Pharmacol 2011 Feb;57(2):133-9 PMID: 20881603 PMCID: PMC3047599 10/01/2010
  • Measuring FMD in the brachial artery: how important is QRS gating? (Kizhakekuttu TJ, Gutterman DD, Phillips SA, Jurva JW, Arthur EI, Das E, Widlansky ME) J Appl Physiol (1985) 2010 Oct;109(4):959-65 PMID: 20671033 PMCID: PMC2963331 07/31/2010
  • Altered mitochondrial membrane potential, mass, and morphology in the mononuclear cells of humans with type 2 diabetes. (Widlansky ME, Wang J, Shenouda SM, Hagen TM, Smith AR, Kizhakekuttu TJ, Kluge MA, Weihrauch D, Gutterman DD, Vita JA) Transl Res 2010 Jul;156(1):15-25 PMID: 20621033 PMCID: PMC2904361 07/14/2010
  • Resurrecting hope for antioxidant treatment of cardiovascular disease: focus on mitochondria. (O'Connor PM, Gutterman DD) Circ Res 2010 Jul 9;107(1):9-11 PMID: 20616335 PMCID: PMC2929761 07/10/2010
  • Folic acid supplementation improves vascular function in amenorrheic runners. (Hoch AZ, Lynch SL, Jurva JW, Schimke JE, Gutterman DD) Clin J Sport Med 2010 May;20(3):205-10 PMID: 20445362 05/07/2010
  • TRPV4-mediated endothelial Ca2+ influx and vasodilation in response to shear stress. (Mendoza SA, Fang J, Gutterman DD, Wilcox DA, Bubolz AH, Li R, Suzuki M, Zhang DX) Am J Physiol Heart Circ Physiol 2010 Feb;298(2):H466-76 PMID: 19966050 PMCID: PMC2822567 12/08/2009
  • Prevalence of the female athlete triad in high school athletes and sedentary students. (Hoch AZ, Pajewski NM, Moraski L, Carrera GF, Wilson CR, Hoffmann RG, Schimke JE, Gutterman DD) Clin J Sport Med 2009 Sep;19(5):421-8 PMID: 19741317 PMCID: PMC2848387 09/11/2009
  • C-reactive protein: a multipronged assailant on endothelium-dependent vasodilation. (Larsen BT, Gutterman DD) J Mol Cell Cardiol 2009 Aug;47(2):177-9 PMID: 19450604 05/20/2009
  • Systemic and microvascular oxidative stress induced by light chain amyloidosis. (Migrino RQ, Hari P, Gutterman DD, Bright M, Truran S, Schlundt B, Phillips SA) Int J Cardiol 2010 Nov 5;145(1):67-8 PMID: 19446898 PMCID: PMC2974792 05/19/2009
  • Protective actions of epoxyeicosatrienoic acid: dual targeting of cardiovascular PI3K and KATP channels. (Bodiga S, Zhang R, Jacobs DE, Larsen BT, Tampo A, Manthati VL, Kwok WM, Zeldin DC, Falck JR, Gutterman DD, Jacobs ER, Medhora MM) J Mol Cell Cardiol 2009 Jun;46(6):978-88 PMID: 19336274 PMCID: PMC2796716 04/02/2009
  • Silent myocardial ischemia. (Gutterman DD) Circ J 2009 May;73(5):785-97 PMID: 19282605 03/14/2009
  • Bradykinin-induced dilation of human coronary arterioles requires NADPH oxidase-derived reactive oxygen species. (Larsen BT, Bubolz AH, Mendoza SA, Pritchard KA Jr, Gutterman DD) Arterioscler Thromb Vasc Biol 2009 May;29(5):739-45 PMID: 19213944 PMCID: PMC2727937 02/14/2009
  • Vascular control in humans: focus on the coronary microcirculation. (Liu Y, Gutterman DD) Basic Res Cardiol 2009 May;104(3):211-27 PMID: 19190954 PMCID: PMC3045058 02/05/2009
  • Transient receptor potential vanilloid type 4-deficient mice exhibit impaired endothelium-dependent relaxation induced by acetylcholine in vitro and in vivo. (Zhang DX, Mendoza SA, Bubolz AH, Mizuno A, Ge ZD, Li R, Warltier DC, Suzuki M, Gutterman DD) Hypertension 2009 Mar;53(3):532-8 PMID: 19188524 PMCID: PMC2694062 02/04/2009
  • Possible relationship of folic Acid supplementation and improved flow-mediated dilation in premenopausal, eumenorrheic athletic women. (Hoch AZ, Pajewski NM, Hoffmann RG, Schimke JE, Gutterman DD) J Sports Sci Med 2009;8(1):123-9 PMID: 24150565 PMCID: PMC3737801 01/01/2009
  • Effects of limb electrode placement on the 12- and 16-lead electrocardiogram. (Farrell RM, Syed A, Syed A, Gutterman DD) J Electrocardiol 2008 Nov-Dec;41(6):536-45 PMID: 18790505 09/16/2008
  • The intermediate-conductance calcium-activated potassium channel KCa3.1 contributes to atherogenesis in mice and humans. (Toyama K, Wulff H, Chandy KG, Azam P, Raman G, Saito T, Fujiwara Y, Mattson DL, Das S, Melvin JE, Pratt PF, Hatoum OA, Gutterman DD, Harder DR, Miura H) J Clin Invest 2008 Sep;118(9):3025-37 PMID: 18688283 PMCID: PMC2496961 08/09/2008
  • Age-related attenuation of isoflurane preconditioning in human atrial cardiomyocytes: roles for mitochondrial respiration and sarcolemmal adenosine triphosphate-sensitive potassium channel activity. (Mio Y, Bienengraeber MW, Marinovic J, Gutterman DD, Rakic M, Bosnjak ZJ, Stadnicka A) Anesthesiology 2008 Apr;108(4):612-20 PMID: 18362592 PMCID: PMC2697447 03/26/2008
  • Endothelial cytoskeletal elements are critical for flow-mediated dilation in human coronary arterioles. (Liu Y, Li H, Bubolz AH, Zhang DX, Gutterman DD) Med Biol Eng Comput 2008 May;46(5):469-78 PMID: 18340474 PMCID: PMC2702135 03/15/2008
  • Benefit of low-fat over low-carbohydrate diet on endothelial health in obesity. (Phillips SA, Jurva JW, Syed AQ, Syed AQ, Kulinski JP, Pleuss J, Hoffmann RG, Gutterman DD) Hypertension 2008 Feb;51(2):376-82 PMID: 18195164 PMCID: PMC2702133 01/16/2008
  • Hydrogen peroxide inhibits cytochrome p450 epoxygenases: interaction between two endothelium-derived hyperpolarizing factors. (Larsen BT, Gutterman DD, Sato A, Toyama K, Campbell WB, Zeldin DC, Manthati VL, Falck JR, Miura H) Circ Res 2008 Jan 4;102(1):59-67 PMID: 17975109 PMCID: PMC2364729 11/03/2007
  • Athletic amenorrhea and endothelial dysfunction. (Hoch AZ, Jurva JW, Staton MA, Thielke R, Hoffmann RG, Pajewski N, Gutterman DD) WMJ 2007 Sep;106(6):301-6 PMID: 17970010 11/01/2007
  • Epoxyeicosatrienoic acids, TRP channels, and intracellular Ca2+ in the vasculature: an endothelium-derived endothelium-hyperpolarizing factor? (Larsen BT, Zhang DX, Gutterman DD) Arterioscler Thromb Vasc Biol 2007 Dec;27(12):2496-8 PMID: 17962695 10/27/2007
  • The female athlete triad and cardiovascular dysfunction. (Hoch AZ, Lal S, Jurva JW, Gutterman DD) Phys Med Rehabil Clin N Am 2007 Aug;18(3):385-400, vii-viii PMID: 17678758 08/07/2007
  • Ebselen reduces nitration and restores voltage-gated potassium channel function in small coronary arteries of diabetic rats. (Bubolz AH, Wu Q, Larsen BT, Gutterman DD, Liu Y) Am J Physiol Heart Circ Physiol 2007 Oct;293(4):H2231-7 PMID: 17675568 08/07/2007
  • The adventitia: the outs and ins of vascular disease. (Pagano PJ, Gutterman DD) Cardiovasc Res 2007 Sep 1;75(4):636-9 PMID: 17678636 PMCID: PMC3897155 08/07/2007
  • Combating nitrate tolerance: a novel endogenous mechanism. (Gutterman DD) Arterioscler Thromb Vasc Biol 2007 Aug;27(8):1673-6 PMID: 17634519 07/20/2007
  • Mitochondrial reactive oxygen species-mediated signaling in endothelial cells. (Zhang DX, Gutterman DD) Am J Physiol Heart Circ Physiol 2007 May;292(5):H2023-31 PMID: 17237240 01/24/2007
  • Beyond vasodilatation: non-vasomotor roles of epoxyeicosatrienoic acids in the cardiovascular system. (Larsen BT, Campbell WB, Gutterman DD) Trends Pharmacol Sci 2007 Jan;28(1):32-8 PMID: 17150260 12/08/2006
  • Relating cardiac performance with oxygen consumption: historical observations continue to spawn scientific discovery. (Gutterman DD, Cowley AW Jr) Am J Physiol Heart Circ Physiol 2006 Dec;291(6):H2555-6 PMID: 17090783 11/09/2006
  • The mechanism of flow-induced dilation in human adipose arterioles involves hydrogen peroxide during CAD. (Phillips SA, Hatoum OA, Gutterman DD) Am J Physiol Heart Circ Physiol 2007 Jan;292(1):H93-100 PMID: 17040967 10/17/2006
  • The effect of exertional hypertension evoked by weight lifting on vascular endothelial function. (Jurva JW, Phillips SA, Syed AQ, Syed AY, Pitt S, Weaver A, Gutterman DD) J Am Coll Cardiol 2006 Aug 1;48(3):588-9 PMID: 16875990 08/01/2006
  • The coronary microcirculation in cyanotic congenital heart disease. (Dedkov EI, Perloff JK, Tomanek RJ, Fishbein MC, Gutterman DD) Circulation 2006 Jul 18;114(3):196-200 PMID: 16831984 07/13/2006
  • Hypoxia, coronary dilation, and the pentose phosphate pathway. (Larsen BT, Gutterman DD) Am J Physiol Heart Circ Physiol 2006 Jun;290(6):H2169-71 PMID: 16687606 05/12/2006
  • Emerging role of epoxyeicosatrienoic acids in coronary vascular function. (Larsen BT, Gutterman DD, Hatoum OA) Eur J Clin Invest 2006 May;36(5):293-300 PMID: 16634832 04/26/2006
  • Protective effects of epoxyeicosatrienoic acids on human endothelial cells from the pulmonary and coronary vasculature. (Dhanasekaran A, Al-Saghir R, Lopez B, Zhu D, Gutterman DD, Jacobs ER, Medhora M) Am J Physiol Heart Circ Physiol 2006 Aug;291(2):H517-31 PMID: 16617127 04/18/2006
  • American College of Chest Physicians' cough guidelines. (Irwin RS, Gutterman DD) Lancet 2006 Mar 25;367(9515):981 PMID: 16564350 03/28/2006
  • American College of Chest Physicians evidence-based guidelines--the next generation: considering resource use and evolution to a single grading system. (Baumann MH, Gutterman DD) Chest 2006 Jan;129(1):10-2 PMID: 16424406 01/21/2006
  • Radiation induces endothelial dysfunction in murine intestinal arterioles via enhanced production of reactive oxygen species. (Hatoum OA, Otterson MF, Kopelman D, Miura H, Sukhotnik I, Larsen BT, Selle RM, Moulder JE, Gutterman DD) Arterioscler Thromb Vasc Biol 2006 Feb;26(2):287-94 PMID: 16322529 12/03/2005
  • Epoxyeicosatrienoic and dihydroxyeicosatrienoic acids dilate human coronary arterioles via BK(Ca) channels: implications for soluble epoxide hydrolase inhibition. (Larsen BT, Miura H, Hatoum OA, Campbell WB, Hammock BD, Zeldin DC, Falck JR, Gutterman DD) Am J Physiol Heart Circ Physiol 2006 Feb;290(2):H491-9 PMID: 16258029 PMCID: PMC1456013 11/01/2005
  • Paradox of simultaneous intestinal ischaemia and hyperaemia in inflammatory bowel disease. (Hatoum OA, Binion DG, Gutterman DD) Eur J Clin Invest 2005 Oct;35(10):599-609 PMID: 16178878 09/24/2005
  • Anticoagulation: American College of Chest Physicians guidelines for the prevention and management of postoperative atrial fibrillation after cardiac surgery. (Epstein AE, Alexander JC, Gutterman DD, Maisel W, Wharton JM, American College of Chest Physicians) Chest 2005 Aug;128(2 Suppl):24S-27S PMID: 16167661 09/20/2005
  • Epidemiology, mechanisms, and risks: American College of Chest Physicians guidelines for the prevention and management of postoperative atrial fibrillation after cardiac surgery. (Hogue CW Jr, Creswell LL, Gutterman DD, Fleisher LA, American College of Chest Physicians) Chest 2005 Aug;128(2 Suppl):9S-16S PMID: 16167659 09/20/2005
  • Peroxynitrite reduces the endothelium-derived hyperpolarizing factor component of coronary flow-mediated dilation in PECAM-1-knockout mice. (Liu Y, Bubolz AH, Shi Y, Newman PJ, Newman DK, Gutterman DD) Am J Physiol Regul Integr Comp Physiol 2006 Jan;290(1):R57-65 PMID: 16166207 09/17/2005
  • Novel mechanism of vasodilation in inflammatory bowel disease. (Hatoum OA, Gauthier KM, Binion DG, Miura H, Telford G, Otterson MF, Campbell WB, Gutterman DD) Arterioscler Thromb Vasc Biol 2005 Nov;25(11):2355-61 PMID: 16141408 09/06/2005
  • Radiation induced small bowel "web" formation is associated with acquired microvascular dysfunction. (Hatoum OA, Binion DG, Phillips SA, O'Loughlin C, Komorowski RA, Gutterman DD, Otterson MF) Gut 2005 Dec;54(12):1797-800 PMID: 16127018 PMCID: PMC1774807 08/30/2005
  • Mitochondria and reactive oxygen species: an evolution in function. (Gutterman DD) Circ Res 2005 Aug 19;97(4):302-4 PMID: 16109924 08/20/2005
  • Mechanism of vasodilation to adenosine in coronary arterioles from patients with heart disease. (Sato A, Terata K, Miura H, Toyama K, Loberiza FR Jr, Hatoum OA, Saito T, Sakuma I, Gutterman DD) Am J Physiol Heart Circ Physiol 2005 Apr;288(4):H1633-40 PMID: 15772334 03/18/2005
  • Redox modulation of vascular tone: focus of potassium channel mechanisms of dilation. (Gutterman DD, Miura H, Liu Y) Arterioscler Thromb Vasc Biol 2005 Apr;25(4):671-8 PMID: 15705931 02/12/2005
  • Role of hydrogen peroxide in ACh-induced dilation of human submucosal intestinal microvessels. (Hatoum OA, Binion DG, Miura H, Telford G, Otterson MF, Gutterman DD) Am J Physiol Heart Circ Physiol 2005 Jan;288(1):H48-54 PMID: 15345486 09/04/2004
  • Nitration and functional loss of voltage-gated K+ channels in rat coronary microvessels exposed to high glucose. (Li H, Gutterman DD, Rusch NJ, Bubolz A, Liu Y) Diabetes 2004 Sep;53(9):2436-42 PMID: 15331556 08/28/2004
  • Coronary vasospasm and the regulation of coronary blood flow. (Konidala S, Gutterman DD) Prog Cardiovasc Dis 2004 Jan-Feb;46(4):349-73 PMID: 14961457 02/13/2004
  • Mechanism of dilation to reactive oxygen species in human coronary arterioles. (Sato A, Sakuma I, Gutterman DD) Am J Physiol Heart Circ Physiol 2003 Dec;285(6):H2345-54 PMID: 14613909 11/14/2003
  • Coronary vascular dysfunction associated with direct current shock injury. (Oltman CL, Clark CB, Kane NL, Zhang Y, Gutterman DD, Dellsperger KC, Kerber RE) Basic Res Cardiol 2003 Nov;98(6):406-15 PMID: 14556086 10/14/2003
  • Mitochondrial sources of H2O2 generation play a key role in flow-mediated dilation in human coronary resistance arteries. (Liu Y, Zhao H, Li H, Kalyanaraman B, Nicolosi AC, Gutterman DD) Circ Res 2003 Sep 19;93(6):573-80 PMID: 12919951 08/16/2003
  • Acquired microvascular dysfunction in inflammatory bowel disease: Loss of nitric oxide-mediated vasodilation. (Hatoum OA, Binion DG, Otterson MF, Gutterman DD) Gastroenterology 2003 Jul;125(1):58-69 PMID: 12851871 07/10/2003
  • Enhancement of antral contractions and vagal afferent signaling with synchronized electrical stimulation. (Peles S, Petersen J, Aviv R, Policker S, Abu-Hatoum O, Ben-Haim SA, Gutterman DD, Sengupta JN) Am J Physiol Gastrointest Liver Physiol 2003 Sep;285(3):G577-85 PMID: 12801883 06/13/2003
  • Elevated glucose impairs cAMP-mediated dilation by reducing Kv channel activity in rat small coronary smooth muscle cells. (Li H, Chai Q, Gutterman DD, Liu Y) Am J Physiol Heart Circ Physiol 2003 Sep;285(3):H1213-9 PMID: 12763748 05/24/2003
  • L-4F, an apolipoprotein A-1 mimetic, dramatically improves vasodilation in hypercholesterolemia and sickle cell disease. (Ou J, Ou Z, Jones DW, Holzhauer S, Hatoum OA, Ackerman AW, Weihrauch DW, Gutterman DD, Guice K, Oldham KT, Hillery CA, Pritchard KA Jr) Circulation 2003 May 13;107(18):2337-41 PMID: 12732610 05/07/2003
  • Is there an association between athletic amenorrhea and endothelial cell dysfunction? (Zeni Hoch A, Dempsey RL, Carrera GF, Wilson CR, Chen EH, Barnabei VM, Sandford PR, Ryan TA, Gutterman DD) Med Sci Sports Exerc 2003 Mar;35(3):377-83 PMID: 12618566 03/06/2003
  • Mechanism of thrombin-induced vasodilation in human coronary arterioles. (Bosnjak JJ, Terata K, Miura H, Sato A, Nicolosi AC, McDonald M, Manthei SA, Saito T, Hatoum OA, Gutterman DD) Am J Physiol Heart Circ Physiol 2003 Apr;284(4):H1080-6 PMID: 12595282 02/22/2003
  • Role for hydrogen peroxide in flow-induced dilation of human coronary arterioles. (Miura H, Bosnjak JJ, Ning G, Saito T, Miura M, Gutterman DD) Circ Res 2003 Feb 7;92(2):e31-40 PMID: 12574154 02/08/2003
  • Diabetes mellitus impairs vasodilation to hypoxia in human coronary arterioles: reduced activity of ATP-sensitive potassium channels. (Miura H, Wachtel RE, Loberiza FR Jr, Saito T, Miura M, Nicolosi AC, Gutterman DD) Circ Res 2003 Feb 7;92(2):151-8 PMID: 12574142 02/08/2003
  • The association of hypertension and secondary cardiovascular disease with sleep-disordered breathing. (Dart RA, Gregoire JR, Gutterman DD, Woolf SH) Chest 2003 Jan;123(1):244-60 PMID: 12527627 01/16/2003
  • Peroxynitrite inhibits Ca2+-activated K+ channel activity in smooth muscle of human coronary arterioles. (Liu Y, Terata K, Chai Q, Li H, Kleinman LH, Gutterman DD) Circ Res 2002 Nov 29;91(11):1070-6 PMID: 12456494 11/29/2002
  • The coronary circulation in diabetes: influence of reactive oxygen species on K+ channel-mediated vasodilation. (Liu Y, Gutterman DD) Vascul Pharmacol 2002 Jan;38(1):43-9 PMID: 12378822 10/16/2002
  • Effect of gender on endothelium-dependent dilation to bradykinin in human adipose microvessels. (Sato A, Miura H, Liu Y, Somberg LB, Otterson MF, Demeure MJ, Schulte WJ, Eberhardt LM, Loberiza FR, Sakuma I, Gutterman DD) Am J Physiol Heart Circ Physiol 2002 Sep;283(3):H845-52 PMID: 12181110 08/16/2002
  • Oxidative stress and potassium channel function. (Liu Y, Gutterman DD) Clin Exp Pharmacol Physiol 2002 Apr;29(4):305-11 PMID: 11985541 05/03/2002
  • Vascular dysfunction in hyperglycemia: is protein kinase C the culprit? (Gutterman DD) Circ Res 2002 Jan 11;90(1):5-7 PMID: 11786509 01/12/2002
  • Calcium-activated potassium channels mask vascular dysfunction associated with oxidized LDL exposure in rabbit aorta. (Bocker JM, Miller FJ, Oltman CL, Chappell DA, Gutterman DD) Jpn Heart J 2001 May;42(3):317-26 PMID: 11605770 10/19/2001
  • High glucose impairs voltage-gated K(+) channel current in rat small coronary arteries. (Liu Y, Terata K, Rusch NJ, Gutterman DD) Circ Res 2001 Jul 20;89(2):146-52 PMID: 11463721 07/21/2001
  • Ouabain-induced coronary vasoconstriction in cats is not neurally mediated. (Nair BA, Murad YZ, Brody MJ, Gutterman DD) Clin Exp Pharmacol Physiol 2001 Jul;28(7):510-7 PMID: 11422216 06/26/2001
  • Flow-induced dilation of human coronary arterioles: important role of Ca(2+)-activated K(+) channels. (Miura H, Wachtel RE, Liu Y, Loberiza FR Jr, Saito T, Miura M, Gutterman DD) Circulation 2001 Apr 17;103(15):1992-8 PMID: 11306529 04/18/2001
  • Human coronary arteriolar dilation to adrenomedullin: role of nitric oxide and K(+) channels. (Terata K, Miura H, Liu Y, Loberiza F, Gutterman DD) Am J Physiol Heart Circ Physiol 2000 Dec;279(6):H2620-6 PMID: 11087213 11/22/2000
  • Prologue: new insights into the regulation of the coronary microcirculation. (Chilian WM, Gutterman DD) Am J Physiol Heart Circ Physiol 2000 Dec;279(6):H2585-6 PMID: 11087207 11/22/2000
  • Impaired dilation of coronary arterioles during increases in myocardial O(2) consumption with hyperglycemia. (Ammar RF Jr, Gutterman DD, Brooks LA, Dellsperger KC) Am J Physiol Endocrinol Metab 2000 Oct;279(4):E868-74 PMID: 11001770 09/23/2000
  • Free radicals mediate endothelial dysfunction of coronary arterioles in diabetes. (Ammar RF Jr, Gutterman DD, Brooks LA, Dellsperger KC) Cardiovasc Res 2000 Aug 18;47(3):595-601 PMID: 10963732 08/30/2000
  • Mechanism of coronary vasodilation to insulin and insulin-like growth factor I is dependent on vessel size. (Oltman CL, Kane NL, Gutterman DD, Bar RS, Dellsperger KC) Am J Physiol Endocrinol Metab 2000 Jul;279(1):E176-81 PMID: 10893337 07/14/2000
  • Acetylcholine-induced arteriolar dilation is reduced in streptozotocin-induced diabetic rats with motor nerve dysfunction. (Terata K, Coppey LJ, Davidson EP, Dunlap JA, Gutterman DD, Yorek MA) Br J Pharmacol 1999 Oct;128(3):837-43 PMID: 10516670 PMCID: PMC1571695 10/12/1999
  • Adventitia-dependent influences on vascular function. (Gutterman DD) Am J Physiol 1999 Oct;277(4 Pt 2):H1265-72 PMID: 10516160 10/12/1999
  • Human coronary arteriolar dilation to bradykinin depends on membrane hyperpolarization: contribution of nitric oxide and Ca2+-activated K+ channels. (Miura H, Liu Y, Gutterman DD) Circulation 1999 Jun 22;99(24):3132-8 PMID: 10377076 06/22/1999
  • Pharmacologic activation of the human coronary microcirculation in vitro: endothelium-dependent dilation and differential responses to acetylcholine. (Miller FJ Jr, Dellsperger KC, Gutterman DD) Cardiovasc Res 1998 Jun;38(3):744-50 PMID: 9747443 09/25/1998
  • Human coronary arteriolar dilation to arachidonic acid depends on cytochrome P-450 monooxygenase and Ca2+-activated K+ channels. (Miura H, Gutterman DD) Circ Res 1998 Sep 7;83(5):501-7 PMID: 9734472 09/12/1998
  • Attenuation of ischemia-induced activation of cardiac sympathetic afferents following brief myocardial ischemia in cats. (Abe T, Morgan D, Sengupta JN, Gebhart GF, Gutterman DD) J Auton Nerv Syst 1998 Jun 30;71(1):28-36 PMID: 9722192 08/29/1998
  • Superoxide production in vascular smooth muscle contributes to oxidative stress and impaired relaxation in atherosclerosis. (Miller FJ Jr, Gutterman DD, Rios CD, Heistad DD, Davidson BL) Circ Res 1998 Jun 29;82(12):1298-305 PMID: 9648726 07/02/1998
  • Thoracic spinal neuron responses to repeated myocardial ischemia and epicardial bradykinin. (Gutterman DD, Pardubsky PD, Pettersen M, Marcus ML, Gebhart GF) Brain Res 1998 Apr 20;790(1-2):293-303 PMID: 9593951 06/17/1998
  • Oxygen-derived free radicals contribute to neural stunning in the canine heart. (Miura H, Morgan DA, Gutterman DD) Am J Physiol 1997 Sep;273(3 Pt 2):H1569-75 PMID: 9321851 10/10/1997
  • Myogenic constriction of human coronary arterioles. (Miller FJ Jr, Dellsperger KC, Gutterman DD) Am J Physiol 1997 Jul;273(1 Pt 2):H257-64 PMID: 9249498 07/11/1997
  • Effects of glycosylated hemoglobin on vascular responses in vitro. (Oltman CL, Gutterman DD, Scott EC, Bocker JM, Dellsperger KC) Cardiovasc Res 1997 Apr;34(1):179-84 PMID: 9217888 04/01/1997
  • Protective role of nerve growth factor against postischemic dysfunction of sympathetic coronary innervation. (Abe T, Morgan DA, Gutterman DD) Circulation 1997 Jan 7;95(1):213-20 PMID: 8994439 01/07/1997
  • Role of adenosine receptor subtypes in neural stunning of sympathetic coronary innervation. (Abe T, Morgan DA, Gutterman DD) Am J Physiol 1997 Jan;272(1 Pt 2):H25-34 PMID: 9038919 01/01/1997
  • Role of parabrachial nucleus in baroreflex-mediated coronary vasoconstriction. (Gutterman DD, Goodson A) Am J Physiol 1996 Sep;271(3 Pt 2):H1079-86 PMID: 8853344 09/01/1996
  • Pheochromocytoma with reversible focal cardiac dysfunction. (Scott IU, Gutterman DD) Am Heart J 1995 Oct;130(4):909-11 PMID: 7572605 10/01/1995
  • Transmural regulation of myocardial perfusion by neuropeptide Y. (Gutterman DD, Morgan DA) Basic Res Cardiol 1995 Jul-Aug;90(4):348-55 PMID: 8534260 07/01/1995
  • Use of an indwelling catheter for examining cardiovascular responses to pericardial administration of bradykinin in rat. (McDermott DA, Meller ST, Gebhart GF, Gutterman DD) Cardiovasc Res 1995 Jul;30(1):39-46 PMID: 7553722 07/01/1995
  • Role of adenosine in postischemic dysfunction of coronary innervation. (Pettersen MD, Abe T, Morgan DA, Gutterman DD) Circ Res 1995 Jan;76(1):95-101 PMID: 8001282 01/01/1995
  • Inhibition of nitric oxide synthesis augments centrally induced sympathetic coronary vasoconstriction in cats. (Goodson AR, Leibold JM, Gutterman DD) Am J Physiol 1994 Oct;267(4 Pt 2):H1272-8 PMID: 7943371 10/01/1994
  • Detection of cardioembolic sources with echocardiography. (Lindower PD, Gutterman DD) Compr Ther 1994;20(3):174-80 PMID: 8187459 01/01/1994
  • Coronary vasoconstrictor pathway from anterior hypothalamus includes neurons in RVLM. (Goodson AR, LaMaster TS, Gutterman DD) Am J Physiol 1993 Dec;265(6 Pt 2):R1311-7 PMID: 8285271 12/01/1993
  • Use of echocardiography in detecting cardiac sources of embolus. (Gutterman DD, Ayres RW) Echocardiography 1993 May;10(3):311-20 PMID: 10148638 04/08/1993
  • Coronary vascular response to the cerebral ischemia reflex. (De Boel SL, Gutterman DD) Hypertension 1993 Feb;21(2):216-21 PMID: 8428783 02/01/1993
  • Prediction of immediate ventricular arrhythmias after coronary artery ligation. (Ben-Haim SA, Becker B, Gutterman DD, Edoute Y, Kaplinsky E, Palti Y) J Am Coll Cardiol 1992 Nov 1;20(5):1270-6 PMID: 1401631 11/01/1992
  • Effect of brief myocardial ischemia on sympathetic coronary vasoconstriction. (Gutterman DD, Morgan DA, Miller FJ) Circ Res 1992 Oct;71(4):960-9 PMID: 1516166 10/01/1992
  • Patterns of hemodynamic responses associated with central activation of coronary vasoconstriction. (Jones LF, Gutterman DD, Brody MJ) Am J Physiol 1992 Feb;262(2 Pt 2):R276-83 PMID: 1539736 02/01/1992
  • Activation in the region of parabrachial nucleus elicits neurogenically mediated coronary vasoconstriction. (Miller FJ Jr, Marcus ML, Brody MJ, Gutterman DD) Am J Physiol 1991 Nov;261(5 Pt 2):H1585-96 PMID: 1683174 11/11/1991
  • Role of medullary lateral reticular formation in baroreflex coronary vasoconstriction. (Gutterman DD, Arthur JM, Pardubsky PD, Gebhart GF, Marcus ML, Brody MJ) Brain Res 1991 Aug 23;557(1-2):202-9 PMID: 1660752 08/23/1991
  • Coronary vasoconstriction during stimulation in hypothalamic defense region. (Arthur JM, Bonham AC, Gutterman DD, Gebhart GF, Marcus ML, Brody MJ) Am J Physiol 1991 Feb;260(2 Pt 2):R335-45 PMID: 1996721 02/01/1991
  • Connections between hypothalamus and medullary reticular formation mediate coronary vasoconstriction. (Gutterman DD, Bonham AC, Gebhart GF, Marcus ML, Brody MJ) Am J Physiol 1990 Sep;259(3 Pt 2):H917-24 PMID: 2396696 09/01/1990
  • Characterization of coronary vasoconstrictor site in medullary reticular formation. (Gutterman DD, Bonham AC, Arthur JM, Gebhart GF, Marcus ML, Brody MJ) Am J Physiol 1989 Apr;256(4 Pt 2):H1218-27 PMID: 2565092 04/01/1989
  • Characterization of the acute left ventricular thrombus: hermit or nomad? (Gutterman DD) J Am Coll Cardiol 1989 Mar 1;13(3):565-6 PMID: 2918161 03/01/1989
  • Neurogenic regulation of coronary blood flow: evidence for a central nervous system pathway. (Bonham AC, Gutterman DD, Arthur JM, Marcus ML, Gebhart GF, Brody MJ) Circ Res 1987 Nov;61(5 Pt 2):II42-6 PMID: 2444359 11/01/1987
  • Electrical stimulation in perifornical lateral hypothalamus decreases coronary blood flow in cats. (Bonham AC, Gutterman DD, Arthur JM, Marcus ML, Gebhart GF, Brody MJ) Am J Physiol 1987 Mar;252(3 Pt 2):H474-84 PMID: 2881488 03/01/1987
  • Failure of pyruvate to salvage myocardium after prolonged ischemia. (Gutterman DD, Chilian WM, Eastham CL, Inou T, White CW, Marcus ML) Am J Physiol 1986 Jan;250(1 Pt 2):H114-20 PMID: 3942230 01/01/1986
  • Differential reactivity to 5-hydroxytryptamine in canine coronary arteries. (Gutterman DD, Rusch NJ, Hermsmeyer K, Dole WP) Blood Vessels 1986;23(4-5):165-72 PMID: 3779106 01/01/1986
  • Last update: 07/16/2015