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David R. Harder PhD

David R. Harder PhD

Associate Dean, Professor

Institution: Medical College of Wisconsin
Department: Physiology
Program: Cardiovascular Research Center

Member of the Cancer Center
Member of the Cardiovascular Center
Member of the Neuroscience Research Center


Publications

  • Expression of CYP 4A ω- hydroxylase and formation of 20-hydroxyeicosatetreanoic acid (20-HETE) in cultured rat brain astrocytes (Gebremedhin D, David Zhang X, Carver K, Rau N, Roman, R, Harder DR) Elsevier 01/04/2016
  • Inhibition of soluble epoxide hydrolase augments astrocyte release of vascular endothelial growth factor and neuronal recovery after oxygen –glucose deprivation (Zhang Y, Hong G, Lee KS, Hammock B, Gebremedhin D, Koehler R, Harder DR, Sapirstein A) Journal of Neurochemistry 01/04/2016
  • Elevated Aminopeptidase P Attenuates Cerebral Arterial Responses to Bradykinin in Fawn-Hooded Hypertensive Rats. (Hye Khan MA, Sharma A, Rarick KR, Roman RJ, Harder DR, Imig JD) PLoS One 2015;10(12):e0145335 PMID: 26683993 PMCID: PMC4686180 12/20/2015
  • Correction: Astrocytes Directly Influence Tumor Cell Invasion and Metastasis In Vivo. (Wang L, Cossette SM, Rarick KR, Gershan J, Dwinell MB, Harder DR, Ramchandran R) PLoS One 2015;10(8):e0137369 PMID: 26322640 PMCID: PMC4554722 09/01/2015
  • Contribution of epoxyeicosatrienoic acids to the cerebral blood flow response to hypoxemia. (Liu X, Gebremedhin D, Harder DR, Koehler RC) J Appl Physiol (1985) 2015 Nov 15;119(10):1202-9 PMID: 25792716 PMCID: PMC4747900 03/21/2015
  • Zinc-finger nuclease knockout of dual-specificity protein phosphatase-5 enhances the myogenic response and autoregulation of cerebral blood flow in FHH.1BN rats. (Fan F, Geurts AM, Pabbidi MR, Smith SV, Harder DR, Jacob H, Roman RJ) PLoS One 2014;9(11):e112878 PMID: 25397684 PMCID: PMC4232417 11/15/2014
  • Rhythmic expression of cytochrome P450 epoxygenases CYP4x1 and CYP2c11 in the rat brain and vasculature. (Carver KA, Lourim D, Tryba AK, Harder DR) Am J Physiol Cell Physiol 2014 Dec 01;307(11):C989-98 PMID: 25055826 PMCID: PMC4254955 07/25/2014
  • Enhanced large conductance K+ channel activity contributes to the impaired myogenic response in the cerebral vasculature of Fawn Hooded Hypertensive rats. (Pabbidi MR, Mazur O, Fan F, Farley JM, Gebremedhin D, Harder DR, Roman RJ) Am J Physiol Heart Circ Physiol 2014 Apr 01;306(7):H989-H1000 PMID: 24464756 PMCID: PMC3962634 01/28/2014
  • Astrocytes directly influence tumor cell invasion and metastasis in vivo. (Wang L, Cossette SM, Rarick KR, Gershan J, Dwinell MB, Harder DR, Ramchandran R) PLoS One 2013;8(12):e80933 PMID: 24324647 PMCID: PMC3851470 12/11/2013
  • Epoxyeicosatrienoic acids pretreatment improves amyloid β-induced mitochondrial dysfunction in cultured rat hippocampal astrocytes. (Sarkar P, Zaja I, Bienengraeber M, Rarick KR, Terashvili M, Canfield S, Falck JR, Harder DR) Am J Physiol Heart Circ Physiol 2014 Feb 15;306(4):H475-84 PMID: 24285116 PMCID: PMC3920242 11/29/2013
  • Endogenous events modulating myogenic regulation of cerebrovascular function. (Gebremedhin D, Gopalakrishnan S, Harder DR) Curr Vasc Pharmacol 2014;12(6):810-7 PMID: 24066934 09/27/2013
  • Redox signaling via oxidative inactivation of PTEN modulates pressure-dependent myogenic tone in rat middle cerebral arteries. (Gebremedhin D, Terashvili M, Wickramasekera N, Zhang DX, Rau N, Miura H, Harder DR) PLoS One 2013;8(7):e68498 PMID: 23861911 PMCID: PMC3702596 07/19/2013
  • Role of dual-specificity protein phosphatase-5 in modulating the myogenic response in rat cerebral arteries. (Wickramasekera NT, Gebremedhin D, Carver KA, Vakeel P, Ramchandran R, Schuett A, Harder DR) J Appl Physiol (1985) 2013 Jan 15;114(2):252-61 PMID: 23172031 PMCID: PMC3544499 11/23/2012
  • Identification of a region of rat chromosome 1 that impairs the myogenic response and autoregulation of cerebral blood flow in fawn-hooded hypertensive rats. (Pabbidi MR, Juncos J, Juncos L, Renic M, Tullos HJ, Lazar J, Jacob HJ, Harder DR, Roman RJ) Am J Physiol Heart Circ Physiol 2013 Jan 15;304(2):H311-7 PMID: 23144316 PMCID: PMC3543673 11/13/2012
  • The protective effect of astrocyte-derived 14,15-epoxyeicosatrienoic acid on hydrogen peroxide-induced cell injury in astrocyte-dopaminergic neuronal cell line co-culture. (Terashvili M, Sarkar P, Nostrand MV, Falck JR, Harder DR) Neuroscience 2012 Oct 25;223:68-76 PMID: 22863680 PMCID: PMC4003556 08/07/2012
  • Attenuation of neonatal ischemic brain damage using a 20-HETE synthesis inhibitor. (Yang ZJ, Carter EL, Kibler KK, Kwansa H, Crafa DA, Martin LJ, Roman RJ, Harder DR, Koehler RC) J Neurochem 2012 Apr;121(1):168-79 PMID: 22251169 PMCID: PMC3303996 01/19/2012
  • Protective effect of 20-HETE inhibition in a model of oxygen-glucose deprivation in hippocampal slice cultures. (Renic M, Kumar SN, Gebremedhin D, Florence MA, Gerges NZ, Falck JR, Harder DR, Roman RJ) Am J Physiol Heart Circ Physiol 2012 Mar 15;302(6):H1285-93 PMID: 22245774 PMCID: PMC3311475 01/17/2012
  • Reactive oxygen species modulate astrocyte and capillary cell functions in the regulation of cerebral blood flow. In: Hand Book of Systems Biology of Oxidative Stress (Gebremedhin D, Wickramasekera NT, and Harder DR) Hand Book of Systems Biology of Oxidative Stress 01/02/2012
  • Relative contribution of cyclooxygenases, epoxyeicosatrienoic acids, and pH to the cerebral blood flow response to vibrissal stimulation. (Liu X, Li C, Falck JR, Harder DR, Koehler RC) Am J Physiol Heart Circ Physiol 2012 Mar 01;302(5):H1075-85 PMID: 22198176 PMCID: PMC3311453 12/27/2011
  • Differential effect of amyloid β on the cytochrome P450 epoxygenase activity in rat brain. (Sarkar P, Narayanan J, Harder DR) Neuroscience 2011 Oct 27;194:241-9 PMID: 21843605 PMCID: PMC3183272 08/17/2011
  • Epoxyeicosatrienoic acid-dependent cerebral vasodilation evoked by metabotropic glutamate receptor activation in vivo. (Liu X, Li C, Gebremedhin D, Hwang SH, Hammock BD, Falck JR, Roman RJ, Harder DR, Koehler RC) Am J Physiol Heart Circ Physiol 2011 Aug;301(2):H373-81 PMID: 21602473 PMCID: PMC3154671 05/24/2011
  • Cytochrome P450 eicosanoids and cerebral vascular function. (Imig JD, Simpkins AN, Renic M, Harder DR) Expert Rev Mol Med 2011 Mar 01;13:e7 PMID: 21356152 PMCID: PMC3613250 03/02/2011
  • Pressure-induced myogenic tone and role of 20-HETE in mediating autoregulation of cerebral blood flow. (Harder DR, Narayanan J, Gebremedhin D) Am J Physiol Heart Circ Physiol 2011 May;300(5):H1557-65 PMID: 21257913 PMCID: PMC3283039 01/25/2011
  • Adenosine can mediate its actions through generation of reactive oxygen species. (Gebremedhin D, Weinberger B, Lourim D, Harder DR) J Cereb Blood Flow Metab 2010 Oct;30(10):1777-90 PMID: 20531463 PMCID: PMC3023402 06/10/2010
  • Onset of pulmonary ventilation in fetal sheep produces pial arteriolar constriction dependent on cytochrome p450 omega-hydroxylase activity. (Ohata H, Gebremedhin D, Narayanan J, Harder DR, Koehler RC) J Appl Physiol (1985) 2010 Aug;109(2):412-7 PMID: 20489034 PMCID: PMC2928585 05/22/2010
  • Endothelin rather than 20-HETE contributes to loss of pial arteriolar dilation during focal cerebral ischemia with and without polymeric hemoglobin transfusion. (Cao S, Wang LC, Kwansa H, Roman RJ, Harder DR, Koehler RC) Am J Physiol Regul Integr Comp Physiol 2009 May;296(5):R1412-8 PMID: 19261918 PMCID: PMC2689832 03/06/2009
  • Astrocytes and the regulation of cerebral blood flow. (Koehler RC, Roman RJ, Harder DR) Trends Neurosci 2009 Mar;32(3):160-9 PMID: 19162338 01/24/2009
  • Cutting edge: the metalloproteinase ADAM17/TNF-alpha-converting enzyme regulates proteolytic shedding of the MHC class I-related chain B protein. (Boutet P, Agüera-González S, Atkinson S, Pennington CJ, Edwards DR, Murphy G, Reyburn HT, Valés-Gómez M) J Immunol 2009 Jan 01;182(1):49-53 PMID: 19109134 12/26/2008
  • Effect of 20-HETE inhibition on infarct volume and cerebral blood flow after transient middle cerebral artery occlusion. (Renic M, Klaus JA, Omura T, Kawashima N, Onishi M, Miyata N, Koehler RC, Harder DR, Roman RJ) J Cereb Blood Flow Metab 2009 Mar;29(3):629-39 PMID: 19107134 PMCID: PMC2821901 12/25/2008
  • Elevated production of 20-HETE in the cerebral vasculature contributes to severity of ischemic stroke and oxidative stress in spontaneously hypertensive rats. (Dunn KM, Renic M, Flasch AK, Harder DR, Falck J, Roman RJ) Am J Physiol Heart Circ Physiol 2008 Dec;295(6):H2455-65 PMID: 18952718 PMCID: PMC2614536 10/28/2008
  • Low-flow perfusion of guinea pig isolated hearts with 26 degrees C air-saturated Lifor solution for 20 hours preserves function and metabolism. (Stowe DF, Camara AK, Heisner JS, Aldakkak M, Harder DR) J Heart Lung Transplant 2008 Sep;27(9):1008-15 PMID: 18765194 PMCID: PMC2720038 09/04/2008
  • Increased blood pressure in mice lacking cytochrome P450 2J5. (Athirakul K, Bradbury JA, Graves JP, DeGraff LM, Ma J, Zhao Y, Couse JF, Quigley R, Harder DR, Zhao X, Imig JD, Pedersen TL, Newman JW, Hammock BD, Conley AJ, Korach KS, Coffman TM, Zeldin DC) FASEB J 2008 Dec;22(12):4096-108 PMID: 18716027 PMCID: PMC2614614 08/22/2008
  • The intermediate-conductance calcium-activated potassium channel KCa3.1 contributes to atherogenesis in mice and humans. (Toyama K, Wulff H, Chandy KG, Azam P, Raman G, Saito T, Fujiwara Y, Mattson DL, Das S, Melvin JE, Pratt PF, Hatoum OA, Gutterman DD, Harder DR, Miura H) J Clin Invest 2008 Sep;118(9):3025-37 PMID: 18688283 PMCID: PMC2496961 08/09/2008
  • Ceramide elevates 12-hydroxyeicosatetraenoic acid levels and upregulates 12-lipoxygenase in rat primary hippocampal cell cultures containing predominantly astrocytes. (Prasad VV, Nithipatikom K, Harder DR) Neurochem Int 2008 Dec;53(6-8):220-9 PMID: 18680775 08/06/2008
  • Interaction of nitric oxide, 20-HETE, and EETs during functional hyperemia in whisker barrel cortex. (Liu X, Li C, Falck JR, Roman RJ, Harder DR, Koehler RC) Am J Physiol Heart Circ Physiol 2008 Aug;295(2):H619-31 PMID: 18502903 PMCID: PMC2519225 05/27/2008
  • Antinociception produced by 14,15-epoxyeicosatrienoic acid is mediated by the activation of beta-endorphin and met-enkephalin in the rat ventrolateral periaqueductal gray. (Terashvili M, Tseng LF, Wu HE, Narayanan J, Hart LM, Falck JR, Pratt PF, Harder DR) J Pharmacol Exp Ther 2008 Aug;326(2):614-22 PMID: 18492947 PMCID: PMC2567871 05/22/2008
  • Antiangiogenic effect of inhibitors of cytochrome P450 on rats with glioblastoma multiforme. (Zagorac D, Jakovcevic D, Gebremedhin D, Harder DR) J Cereb Blood Flow Metab 2008 Aug;28(8):1431-9 PMID: 18414496 PMCID: PMC2637201 04/17/2008
  • Role of 20-HETE in the hypoxia-induced activation of Ca2+-activated K+ channel currents in rat cerebral arterial muscle cells. (Gebremedhin D, Yamaura K, Harder DR) Am J Physiol Heart Circ Physiol 2008 Jan;294(1):H107-20 PMID: 17906097 10/02/2007
  • (+)-Morphine and (-)-morphine stereoselectively attenuate the (-)-morphine-produced tail-flick inhibition via the naloxone-sensitive sigma receptor in the ventral periaqueductal gray of the rat. (Terashvili M, Wu HE, Moore RM, Harder DR, Tseng LF) Eur J Pharmacol 2007 Sep 24;571(1):1-7 PMID: 17597599 PMCID: PMC3718891 06/29/2007
  • Interaction of mechanisms involving epoxyeicosatrienoic acids, adenosine receptors, and metabotropic glutamate receptors in neurovascular coupling in rat whisker barrel cortex. (Shi Y, Liu X, Gebremedhin D, Falck JR, Harder DR, Koehler RC) J Cereb Blood Flow Metab 2008 Jan;28(1):111-25 PMID: 17519974 PMCID: PMC2204069 05/24/2007
  • Role of astrocytes in matching blood flow to neuronal activity. (Jakovcevic D, Harder DR) Curr Top Dev Biol 2007;79:75-97 PMID: 17498548 05/15/2007
  • Ten-hour preservation of guinea pig isolated hearts perfused at low flow with air-saturated Lifor solution at 26{degrees}C: comparison to ViaSpan solution. (Stowe DF, Camara AK, Heisner JS, Aldakkak M, Harder DR) Am J Physiol Heart Circ Physiol 2007 Jul;293(1):H895-901 PMID: 17434975 04/17/2007
  • Hydrogen peroxide induces nitric oxide and proteosome activity in endothelial cells: a bell-shaped signaling response. (Thomas S, Kotamraju S, Zielonka J, Harder DR, Kalyanaraman B) Free Radic Biol Med 2007 Apr 01;42(7):1049-61 PMID: 17349932 PMCID: PMC2692187 03/14/2007
  • Emerging mechanisms for growth and protection of the vasculature by cytochrome P450-derived products of arachidonic acid and other eicosanoids. (Medhora M, Dhanasekaran A, Gruenloh SK, Dunn LK, Gabrilovich M, Falck JR, Harder DR, Jacobs ER, Pratt PF) Prostaglandins Other Lipid Mediat 2007 Jan;82(1-4):19-29 PMID: 17164129 12/14/2006
  • Reactive oxygen species cerebral autoregulation in health and disease. (Terashvili M, Pratt PF, Gebremedhin D, Narayanan J, Harder DR) Pediatr Clin North Am 2006 Oct;53(5):1029-37, xi PMID: 17027622 PMCID: PMC2533262 10/10/2006
  • Contribution of epoxyeicosatrienoic acids to the hypoxia-induced activation of Ca2+ -activated K+ channel current in cultured rat hippocampal astrocytes. (Yamaura K, Gebremedhin D, Zhang C, Narayanan J, Hoefert K, Jacobs ER, Koehler RC, Harder DR) Neuroscience 2006 Dec;143(3):703-16 PMID: 17027168 10/10/2006
  • Reversal of delayed vasospasm by TS-011 in the dual hemorrhage dog model of subarachnoid hemorrhage. (Hacein-Bey L, Harder DR, Meier HT, Varelas PN, Miyata N, Lauer KK, Cusick JF, Roman RJ) AJNR Am J Neuroradiol 2006 Jun-Jul;27(6):1350-4 PMID: 16775295 06/16/2006
  • Recommendations of the National Heart, Lung, and Blood Institute working group on cerebrovascular biology and disease. (Iadecola C, Goldman SS, Harder DR, Heistad DD, Katusic ZS, Moskowitz MA, Simard JM, Sloan MA, Traystman RJ, Velletri PA) Stroke 2006 Jun;37(6):1578-81 PMID: 16627792 PMCID: PMC2730969 04/22/2006
  • Endothelial dysfunction and hypertension in rats transduced with CYP4A2 adenovirus. (Harder DR, Roman RJ) Circ Res 2006 Apr 14;98(7):866-7 PMID: 16614311 04/15/2006
  • Effect of a new inhibitor of the synthesis of 20-HETE on cerebral ischemia reperfusion injury. (Omura T, Tanaka Y, Miyata N, Koizumi C, Sakurai T, Fukasawa M, Hachiuma K, Minagawa T, Susumu T, Yoshida S, Nakaike S, Okuyama S, Harder DR, Roman RJ) Stroke 2006 May;37(5):1307-13 PMID: 16601220 04/08/2006
  • Role of astrocytes in cerebrovascular regulation. (Koehler RC, Gebremedhin D, Harder DR) J Appl Physiol (1985) 2006 Jan;100(1):307-17 PMID: 16357084 PMCID: PMC1819408 12/17/2005
  • The effect of superoxide anion on autoregulation of cerebral blood flow. (Zagorac D, Yamaura K, Zhang C, Roman RJ, Harder DR) Stroke 2005 Dec;36(12):2589-94 PMID: 16293785 11/19/2005
  • Hemoglobin, NO, and 20-HETE interactions in mediating cerebral vasoconstriction following SAH. (Takeuchi K, Miyata N, Renic M, Harder DR, Roman RJ) Am J Physiol Regul Integr Comp Physiol 2006 Jan;290(1):R84-9 PMID: 16166205 09/17/2005
  • Reversal of delayed vasospasm by an inhibitor of the synthesis of 20-HETE. (Takeuchi K, Renic M, Bohman QC, Harder DR, Miyata N, Roman RJ) Am J Physiol Heart Circ Physiol 2005 Nov;289(5):H2203-11 PMID: 15964920 06/21/2005
  • Beneficial effects of a new 20-hydroxyeicosatetraenoic acid synthesis inhibitor, TS-011 [N-(3-chloro-4-morpholin-4-yl) phenyl-N'-hydroxyimido formamide], on hemorrhagic and ischemic stroke. (Miyata N, Seki T, Tanaka Y, Omura T, Taniguchi K, Doi M, Bandou K, Kametani S, Sato M, Okuyama S, Cambj-Sapunar L, Harder DR, Roman RJ) J Pharmacol Exp Ther 2005 Jul;314(1):77-85 PMID: 15831442 04/16/2005
  • Mechanisms regulating cerebral blood flow as therapeutic targets. (Pratt PF, Medhora M, Harder DR) Curr Opin Investig Drugs 2004 Sep;5(9):952-6 PMID: 15503650 10/27/2004
  • Ca-induced Ca release: lessons regarding cell models. (Harder DR) Am J Physiol Cell Physiol 2004 Nov;287(5):C1165-6 PMID: 15475514 10/12/2004
  • Ca-induced Ca release: lessons regarding cell models. (Harder DR) Am J Physiol Heart Circ Physiol 2004 Nov;287(5):H1885-6 PMID: 15475522 10/12/2004
  • Degenerin/epithelial Na+ channel proteins: components of a vascular mechanosensor. (Drummond HA, Gebremedhin D, Harder DR) Hypertension 2004 Nov;44(5):643-8 PMID: 15381679 09/24/2004
  • Dependency of cortical functional hyperemia to forepaw stimulation on epoxygenase and nitric oxide synthase activities in rats. (Peng X, Zhang C, Alkayed NJ, Harder DR, Koehler RC) J Cereb Blood Flow Metab 2004 May;24(5):509-17 PMID: 15129182 05/07/2004
  • Effects of a 20-HETE antagonist and agonists on cerebral vascular tone. (Yu M, Cambj-Sapunar L, Kehl F, Maier KG, Takeuchi K, Miyata N, Ishimoto T, Reddy LM, Falck JR, Gebremedhin D, Harder DR, Roman RJ) Eur J Pharmacol 2004 Feb 23;486(3):297-306 PMID: 14985052 02/27/2004
  • Contribution of 5-hydroxytryptamine1B receptors and 20-hydroxyeiscosatetraenoic acid to fall in cerebral blood flow after subarachnoid hemorrhage. (Cambj-Sapunar L, Yu M, Harder DR, Roman RJ) Stroke 2003 May;34(5):1269-75 PMID: 12677022 04/05/2003
  • Leukotriene B4 omega-side chain hydroxylation by CYP4F5 and CYP4F6. (Bylund J, Harder AG, Maier KG, Roman RJ, Harder DR) Arch Biochem Biophys 2003 Apr 01;412(1):34-41 PMID: 12646265 03/21/2003
  • Metabotropic glutamate receptor activation enhances the activities of two types of Ca2+-activated k+ channels in rat hippocampal astrocytes. (Gebremedhin D, Yamaura K, Zhang C, Bylund J, Koehler RC, Harder DR) J Neurosci 2003 Mar 01;23(5):1678-87 PMID: 12629172 03/12/2003
  • Epoxyeicosatrienoic acids released by astrocytes: Function in cerebral angiogenesis (Zhang C. Harder DH) Excerpta Medica International Congress Series (ICS) 01/01/2003
  • Cerebral capillary endothelial cell mitogenesis and morphogenesis induced by astrocytic epoxyeicosatrienoic Acid. (Zhang C, Harder DR) Stroke 2002 Dec;33(12):2957-64 PMID: 12468797 12/07/2002
  • Interaction of myogenic mechanisms and hypoxic dilation in rat middle cerebral arteries. (Liu Y, Harder DR, Lombard JH) Am J Physiol Heart Circ Physiol 2002 Dec;283(6):H2276-81 PMID: 12388266 10/22/2002
  • Epoxygenase-driven angiogenesis in human lung microvascular endothelial cells. (Medhora M, Daniels J, Mundey K, Fisslthaler B, Busse R, Jacobs ER, Harder DR) Am J Physiol Heart Circ Physiol 2003 Jan;284(1):H215-24 PMID: 12388259 10/22/2002
  • Suppression of cortical functional hyperemia to vibrissal stimulation in the rat by epoxygenase inhibitors. (Peng X, Carhuapoma JR, Bhardwaj A, Alkayed NJ, Falck JR, Harder DR, Traystman RJ, Koehler RC) Am J Physiol Heart Circ Physiol 2002 Nov;283(5):H2029-37 PMID: 12384482 10/18/2002
  • Identification of a novel cytochrome P450, CYP4X1, with unique localization specific to the brain. (Bylund J, Zhang C, Harder DR) Biochem Biophys Res Commun 2002 Aug 23;296(3):677-84 PMID: 12176035 08/15/2002
  • Neuroprotection and P450 2C11 upregulation after experimental transient ischemic attack. (Alkayed NJ, Goyagi T, Joh HD, Klaus J, Harder DR, Traystman RJ, Hurn PD) Stroke 2002 Jun;33(6):1677-84 PMID: 12053011 06/08/2002
  • Mechanism of cGMP contribution to the vasodilator response to NO in rat middle cerebral arteries. (Yu M, Sun CW, Maier KG, Harder DR, Roman RJ) Am J Physiol Heart Circ Physiol 2002 May;282(5):H1724-31 PMID: 11959637 04/18/2002
  • 20-HETE contributes to the acute fall in cerebral blood flow after subarachnoid hemorrhage in the rat. (Kehl F, Cambj-Sapunar L, Maier KG, Miyata N, Kametani S, Okamoto H, Hudetz AG, Schulte ML, Zagorac D, Harder DR, Roman RJ) Am J Physiol Heart Circ Physiol 2002 Apr;282(4):H1556-65 PMID: 11893593 03/15/2002
  • Astrocytes function in matching blood flow to metabolic activity. (Harder DR, Zhang C, Gebremedhin D) News Physiol Sci 2002 Feb;17:27-31 PMID: 11821533 02/01/2002
  • Liquid chromatographic-electrospray ionization-mass spectrometric analysis of cytochrome P450 metabolites of arachidonic acid. (Nithipatikom K, Grall AJ, Holmes BB, Harder DR, Falck JR, Campbell WB) Anal Biochem 2001 Nov 15;298(2):327-36 PMID: 11700990 11/10/2001
  • Prologue: EDHF--what is it? (Campbell WB, Harder DR) Am J Physiol Heart Circ Physiol 2001 Jun;280(6):H2413-6 PMID: 11356592 05/18/2001
  • Renal and cardiovascular actions of 20-hydroxyeicosatetraenoic acid and epoxyeicosatrienoic acids. (Roman RJ, Maier KG, Sun CW, Harder DR, Alonso-Galicia M) Clin Exp Pharmacol Physiol 2000 Nov;27(11):855-65 PMID: 11071299 11/09/2000
  • P-450 epoxygenase and NO synthase inhibitors reduce cerebral blood flow response to N-methyl-D-aspartate. (Bhardwaj A, Northington FJ, Carhuapoma JR, Falck JR, Harder DR, Traystman RJ, Koehler RC) Am J Physiol Heart Circ Physiol 2000 Oct;279(4):H1616-24 PMID: 11009448 09/29/2000
  • Impact factors and the competitive nature of journal publishing. (Harder DR) Am J Physiol Heart Circ Physiol 2000 Aug;279(2):H457 PMID: 10991631 09/19/2000
  • Impact factors and the competitive nature of journal publishing (Harder DR) Am J Physiol Heart Circ Physiol 2000 Aug;279(2):H457-8 PMID: 10924041 08/03/2000
  • Role of cGMP versus 20-HETE in the vasodilator response to nitric oxide in rat cerebral arteries. (Sun CW, Falck JR, Okamoto H, Harder DR, Roman RJ) Am J Physiol Heart Circ Physiol 2000 Jul;279(1):H339-50 PMID: 10899074 07/19/2000
  • Production of 20-HETE and its role in autoregulation of cerebral blood flow. (Gebremedhin D, Lange AR, Lowry TF, Taheri MR, Birks EK, Hudetz AG, Narayanan J, Falck JR, Okamoto H, Roman RJ, Nithipatikom K, Campbell WB, Harder DR) Circ Res 2000 Jul 07;87(1):60-5 PMID: 10884373 07/08/2000
  • Molecular mechanisms controlling nutritive blood flow: role of cytochrome P450 enzymes. (Harder DR, Roman RJ, Gebremedhin D) Acta Physiol Scand 2000 Apr;168(4):543-9 PMID: 10759591 04/12/2000
  • Cerebral microvascular endothelial cell tube formation: role of astrocytic epoxyeicosatrienoic acid release. (Munzenmaier DH, Harder DR) Am J Physiol Heart Circ Physiol 2000 Apr;278(4):H1163-7 PMID: 10749710 04/06/2000
  • Epoxyeicosatrienoic acids constrict isolated pressurized rabbit pulmonary arteries. (Zhu D, Bousamra M 2nd, Zeldin DC, Falck JR, Townsley M, Harder DR, Roman RJ, Jacobs ER) Am J Physiol Lung Cell Mol Physiol 2000 Feb;278(2):L335-43 PMID: 10666118 02/09/2000
  • Contribution of 20-HETE to vasodilator actions of nitric oxide in the cerebral microcirculation. (Alonso-Galicia M, Hudetz AG, Shen H, Harder DR, Roman RJ) Stroke 1999 Dec;30(12):2727-34; discussion 2734 PMID: 10583004 12/03/1999
  • Cytochrome P450 2C is an EDHF synthase in coronary arteries. (Fisslthaler B, Popp R, Kiss L, Potente M, Harder DR, Fleming I, Busse R) Nature 1999 Sep 30;401(6752):493-7 PMID: 10519554 10/16/1999
  • Cannabinoid CB1 receptor of cat cerebral arterial muscle functions to inhibit L-type Ca2+ channel current. (Gebremedhin D, Lange AR, Campbell WB, Hillard CJ, Harder DR) Am J Physiol 1999 Jun;276(6 Pt 2):H2085-93 PMID: 10362691 06/11/1999
  • Cerebrovascular alterations in protein kinase C-mediated constriction in stroke-prone rats. (Smeda JS, King S, Harder DR) Stroke 1999 Mar;30(3):656-61 PMID: 10066867 03/06/1999
  • Endothelium-derived hyperpolarizing factors and vascular cytochrome P450 metabolites of arachidonic acid in the regulation of tone. (Campbell WB, Harder DR) Circ Res 1999 Mar 05;84(4):484-8 PMID: 10066684 03/06/1999
  • Cytochrome P-450 omega-hydroxylase senses O2 in hamster muscle, but not cheek pouch epithelium, microcirculation. (Lombard JH, Kunert MP, Roman RJ, Falck JR, Harder DR, Jackson WF) Am J Physiol 1999 Feb;276(2 Pt 2):H503-8 PMID: 9950851 02/10/1999
  • Role of tyrosine kinase and PKC in the vasoconstrictor response to 20-HETE in renal arterioles. (Sun CW, Falck JR, Harder DR, Roman RJ) Hypertension 1999 Jan;33(1 Pt 2):414-8 PMID: 9931139 02/04/1999
  • A common pathway for regulation of nutritive blood flow to the brain: arterial muscle membrane potential and cytochrome P450 metabolites. (Harder DR, Roman RJ, Gebremedhin D, Birks EK, Lange AR) Acta Physiol Scand 1998 Dec;164(4):527-32 PMID: 9887975 01/15/1999
  • Nitric oxide-20-hydroxyeicosatetraenoic acid interaction in the regulation of K+ channel activity and vascular tone in renal arterioles. (Sun CW, Alonso-Galicia M, Taheri MR, Falck JR, Harder DR, Roman RJ) Circ Res 1998 Nov 30;83(11):1069-79 PMID: 9831701 12/01/1998
  • Contribution of 20-HETE to the vasodilator actions of nitric oxide in renal arteries. (Alonso-Galicia M, Sun CW, Falck JR, Harder DR, Roman RJ) Am J Physiol 1998 Sep;275(3 Pt 2):F370-8 PMID: 9729509 09/08/1998
  • Bioassay of an endothelium-derived hyperpolarizing factor from bovine coronary arteries: role of a cytochrome P450 metabolite. (Gebremedhin D, Harder DR, Pratt PF, Campbell WB) J Vasc Res 1998 Jul-Aug;35(4):274-84 PMID: 9701712 08/14/1998
  • Tissue sources of cytochrome P450 4A and 20-HETE synthesis in rabbit lungs. (Zhu D, Effros RM, Harder DR, Roman RJ, Jacobs ER) Am J Respir Cell Mol Biol 1998 Jul;19(1):121-8 PMID: 9651188 07/03/1998
  • Cat cerebral arterial smooth muscle cells express cytochrome P450 4A2 enzyme and produce the vasoconstrictor 20-HETE which enhances L-type Ca2+ current. (Gebremedhin D, Lange AR, Narayanan J, Aebly MR, Jacobs ER, Harder DR) J Physiol 1998 Mar 15;507 ( Pt 3):771-81 PMID: 9508838 PMCID: PMC2230829 05/23/1998
  • Functional hyperemia in the brain: hypothesis for astrocyte-derived vasodilator metabolites. (Harder DR, Alkayed NJ, Lange AR, Gebremedhin D, Roman RJ) Stroke 1998 Jan;29(1):229-34 PMID: 9445355 01/28/1998
  • Cytochrome P450 metabolites of arachidonic acid as intracellular signaling molecules in vascular tissue. (Harder DR, Lange AR, Gebremedhin D, Birks EK, Roman RJ) J Vasc Res 1997 May-Jun;34(3):237-43 PMID: 9226306 05/01/1997
  • Role of P-450 arachidonic acid epoxygenase in the response of cerebral blood flow to glutamate in rats. (Alkayed NJ, Birks EK, Narayanan J, Petrie KA, Kohler-Cabot AE, Harder DR) Stroke 1997 May;28(5):1066-72 PMID: 9158651 05/01/1997
  • Symposium on potassium channels in blood vessels (Heistad DD, Harder DR) Clinical Experimental Pharmacology Physiology 01/01/1997
  • Inhibition of brain P-450 arachidonic acid epoxygenase decreases baseline cerebral blood flow. (Alkayed NJ, Birks EK, Hudetz AG, Roman RJ, Henderson L, Harder DR) Am J Physiol 1996 Oct;271(4 Pt 2):H1541-6 PMID: 8897950 10/01/1996
  • Identification of a putative microvascular oxygen sensor. (Harder DR, Narayanan J, Birks EK, Liard JF, Imig JD, Lombard JH, Lange AR, Roman RJ) Circ Res 1996 Jul;79(1):54-61 PMID: 8925569 07/01/1996
  • Molecular characterization of an arachidonic acid epoxygenase in rat brain astrocytes. (Alkayed NJ, Narayanan J, Gebremedhin D, Medhora M, Roman RJ, Harder DR) Stroke 1996 May;27(5):971-9 PMID: 8623121 05/01/1996
  • Stereospecific effects of epoxyeicosatrienoic acids on renal vascular tone and K(+)-channel activity. (Zou AP, Fleming JT, Falck JR, Jacobs ER, Gebremedhin D, Harder DR, Roman RJ) Am J Physiol 1996 May;270(5 Pt 2):F822-32 PMID: 8928844 05/01/1996
  • Identification of epoxyeicosatrienoic acids as endothelium-derived hyperpolarizing factors. (Campbell WB, Gebremedhin D, Pratt PF, Harder DR) Circ Res 1996 Mar;78(3):415-23 PMID: 8593700 03/01/1996
  • 20-HETE is an endogenous inhibitor of the large-conductance Ca(2+)-activated K+ channel in renal arterioles. (Zou AP, Fleming JT, Falck JR, Jacobs ER, Gebremedhin D, Harder DR, Roman RJ) Am J Physiol 1996 Jan;270(1 Pt 2):R228-37 PMID: 8769806 01/01/1996
  • Coexistence of two types of Ca(2+)-activated K+ channels in rat renal arterioles. (Gebremedhin D, Kaldunski M, Jacobs ER, Harder DR, Roman RJ) Am J Physiol 1996 Jan;270(1 Pt 2):F69-81 PMID: 8769824 01/01/1996
  • Formation and actions of 20-hydroxyeicosatetraenoic acid in rat renal arterioles. (Imig JD, Zou AP, Stec DE, Harder DR, Falck JR, Roman RJ) Am J Physiol 1996 Jan;270(1 Pt 2):R217-27 PMID: 8769805 01/01/1996
  • Shear activated channels in cell-attached patches of cultured bovine aortic endothelial cells. (Jacobs ER, Cheliakine C, Gebremedhin D, Birks EK, Davies PF, Harder DR) Pflugers Arch 1995 Nov;431(1):129-31 PMID: 8584410 11/01/1995
  • Role of cytochrome P-450 enzymes and metabolites of arachidonic acid in the control of vascular tone. (Harder DR, Campbell WB, Roman RJ) J Vasc Res 1995 Mar-Apr;32(2):79-92 PMID: 7537544 03/01/1995
  • Transduction of physical force by the vascular wall Role of phospholipase C and cytochrome P450 metabolites of arachidonic acid. (Harder DR, Narayanan J, Gebremedhin D, Roman RJ) Trends Cardiovasc Med 1995 Jan-Feb;5(1):7-14 PMID: 21232232 01/01/1995
  • Hypoxia increases the activity of Ca(2+)-sensitive K+ channels in cat cerebral arterial muscle cell membranes. (Gebremedhin D, Bonnet P, Greene AS, England SK, Rusch NJ, Lombard JH, Harder DR) Pflugers Arch 1994 Oct;428(5-6):621-30 PMID: 7838685 10/01/1994
  • Myogenic activation of canine small renal arteries after nonchemical removal of the endothelium. (Liu Y, Harder DR, Lombard JH) Am J Physiol 1994 Jul;267(1 Pt 2):H302-7 PMID: 8048595 07/01/1994
  • Guanine nucleotide-binding proteins in aortic smooth muscle from hypertensive rats. (Li P, Zou AP, al-Kayed NJ, Rusch NJ, Harder DR) Hypertension 1994 Jun;23(6 Pt 2):914-8 PMID: 8206627 06/01/1994
  • Formation and action of a P-450 4A metabolite of arachidonic acid in cat cerebral microvessels. (Harder DR, Gebremedhin D, Narayanan J, Jefcoat C, Falck JR, Campbell WB, Roman R) Am J Physiol 1994 May;266(5 Pt 2):H2098-107 PMID: 8203608 05/01/1994
  • Pressurization of isolated renal arteries increases inositol trisphosphate and diacylglycerol. (Narayanan J, Imig M, Roman RJ, Harder DR) Am J Physiol 1994 May;266(5 Pt 2):H1840-5 PMID: 8203583 05/01/1994
  • Cellular and ionic signal transduction mechanisms for the mechanical activation of renal arterial vascular smooth muscle. (Roman RJ, Harder DR) J Am Soc Nephrol 1993 Oct;4(4):986-96 PMID: 7506944 10/01/1993
  • Elevated renovascular tone in young spontaneously hypertensive rats. Role of cytochrome P-450. (Imig JD, Falck JR, Gebremedhin D, Harder DR, Roman RJ) Hypertension 1993 Sep;22(3):357-64 PMID: 8349328 09/01/1993
  • [Pulmonary valve endocarditis and atrial fibrillation]. (Harder D, Ehses W, Weller P, Deuss U, Winkelmann W) Dtsch Med Wochenschr 1993 Jul 02;118(26):975-8 PMID: 8519232 07/02/1993
  • Functional aspects of eicosanoid hydroxylation by lung and kidney cytochromes P450. Expression of cDNAs in mammalian cells and E. coli. (Masters BS, Clark JE, Roman LJ, Nishimoto M, McCabe TJ, Ortiz de Montellano PR, Plopper CG, Gebremedhin D, Ma YH, Harder DR) J Lipid Mediat 1993 Mar-Apr;6(1-3):353-60 PMID: 8357994 03/01/1993
  • Influence of physical and environmental factors on ion channels in arterial muscle (Harder DR, Gebremedhin D, Roman RJ) Ion Flux in Pulmonary Vascular Control 01/04/1993
  • 20-Hydroxyeicosatetraenoic acid is an endogenous vasoconstrictor of canine renal arcuate arteries. (Ma YH, Gebremedhin D, Schwartzman ML, Falck JR, Clark JE, Masters BS, Harder DR, Roman RJ) Circ Res 1993 Jan;72(1):126-36 PMID: 8417836 01/01/1993
  • Role of cytochrome P-450 in elevating renal vascular tone in spontaneously hypertensive rats. (Gebremedhin D, Ma YH, Imig JD, Harder DR, Roman RJ) J Vasc Res 1993 Jan-Feb;30(1):53-60 PMID: 8435472 01/01/1993
  • Modulation of vascular tone in renal microcirculation by erythrocytes: role of EDRF. (Imig JD, Gebremedhin D, Harder DR, Roman RJ) Am J Physiol 1993 Jan;264(1 Pt 2):H190-5 PMID: 8430846 01/01/1993
  • An angiographic method for in vivo study of arteries of the circle of Willis in small animals. (Harder DR, Schulte ML, Clough AV, Dawson CA) Am J Physiol 1992 Nov;263(5 Pt 2):H1616-22 PMID: 1443212 11/01/1992
  • Distensibility of small veins of the dog lung. (al-Tinawi A, Clough AV, Harder DR, Linehan JH, Rickaby DA, Dawson CA) J Appl Physiol (1985) 1992 Nov;73(5):2158-65 PMID: 1474098 11/01/1992
  • Non-invasive determination of systolic blood pressure by heart sound pattern analysis. (Bartels A, Harder D) Clin Phys Physiol Meas 1992 Aug;13(3):249-56 PMID: 1424474 08/01/1992
  • Mechanism of action of cerebral epoxyeicosatrienoic acids on cerebral arterial smooth muscle. (Gebremedhin D, Ma YH, Falck JR, Roman RJ, VanRollins M, Harder DR) Am J Physiol 1992 Aug;263(2 Pt 2):H519-25 PMID: 1510149 08/01/1992
  • Spontaneous flow oscillations in the cerebral cortex during acute changes in mean arterial pressure. (Hudetz AG, Roman RJ, Harder DR) J Cereb Blood Flow Metab 1992 May;12(3):491-9 PMID: 1569142 05/01/1992
  • Performance on multiple choice/short answer tests is not a sufficient criterion for evaluating the educational value of live animal laboratories in the teaching of physiology. (Dawson CA, Cowley AW Jr, Spurr GB, Osborn JL, Raff H, Forster HV, Harder DR, Liard JF, Lombard JH, Stekiel WJ) Am J Physiol 1991 Dec;261(6 Pt 3):S34-5 PMID: 1755480 12/11/1991
  • Distensibility of small arteries of the dog lung. (al-Tinawi A, Madden JA, Dawson CA, Linehan JH, Harder DR, Rickaby DA) J Appl Physiol (1985) 1991 Nov;71(5):1714-22 PMID: 1761466 11/01/1991
  • Effects of 12-HETE on isolated dog renal arcuate arteries. (Ma YH, Harder DR, Clark JE, Roman RJ) Am J Physiol 1991 Aug;261(2 Pt 2):H451-6 PMID: 1908641 08/01/1991
  • Characterization of an outward K+ current in freshly dispersed cerebral arterial muscle cells. (Bonnet P, Rusch NJ, Harder DR) Pflugers Arch 1991 Apr;418(3):292-6 PMID: 1857636 04/01/1991
  • Inhibitors of cytochrome P-450 attenuate the myogenic response of dog renal arcuate arteries. (Kauser K, Clark JE, Masters BS, Ortiz de Montellano PR, Ma YH, Harder DR, Roman RJ) Circ Res 1991 Apr;68(4):1154-63 PMID: 1901255 04/01/1991
  • Cellular and biochemical mechanisms of pressure-induced myogenic tone in arteries (Harder DR, Roman RJ, Lombard JH) Resistance Arteries, Structure and Function: Excerpta Medica 01/07/1991
  • Structure-function studies and physiological roles of eicosanoids metabolized by cytochrome P450 w-Hydroxylases (Masters BSS, Clark JE, Roman LJ, McCabe TJ, Helm CB, Johnson EF, Ma Y-H, Harder DR, Roman RJ ) Prostaglandins, Leukotrienes, Lipoxins and PAF 01/07/1991
  • Effects of hypoxia on a potassium channel in cat cerebral arterial muscle cells. (Bonnet P, Gebremedhin D, Rush NJ, Harder DR) Z Kardiol 1991;80 Suppl 7:25-7 PMID: 1792816 01/01/1991
  • Enhanced vascular tone in the renal vasculature of spontaneously hypertensive rats. (Gebremedhin D, Fenoy FJ, Harder DR, Roman RJ) Hypertension 1990 Dec;16(6):648-54 PMID: 2246032 12/01/1990
  • Effect of nifedipine on endothelin induced contractions of skeletal muscle arterioles of spontaneously hypertensive rats. (Lougee L, Hinojosa-Laborde C, Harder DR, Lombard JH) Microcirc Endothelium Lymphatics 1990 Aug-Oct;6(4-5):355-68 PMID: 2280745 08/01/1990
  • Enhanced norepinephrine sensitivity in renal arteries at elevated transmural pressure. (Lombard JH, Eskinder H, Kauser K, Osborn JL, Harder DR) Am J Physiol 1990 Jul;259(1 Pt 2):H29-33 PMID: 2375412 07/01/1990
  • Role of the vascular endothelium in regulating the response of small arteries of the dog kidney to transmural pressure elevation and reduced PO2. (Eskinder H, Harder DR, Lombard JH) Circ Res 1990 May;66(5):1427-35 PMID: 2335035 05/01/1990
  • Mechanoreception by the endothelium: mediators and mechanisms of pressure- and flow-induced vascular responses. (Rubanyi GM, Freay AD, Kauser K, Johns A, Harder DR) Blood Vessels 1990;27(2-5):246-57 PMID: 2242445 01/01/1990
  • Endothelium-dependent modulation of endothelin-induced vasoconstriction and membrane depolarization in cat cerebral arteries. (Kauser K, Rubanyi GM, Harder DR) J Pharmacol Exp Ther 1990 Jan;252(1):93-7 PMID: 2405153 01/01/1990
  • Mechanisms of pressure-induced myogenic activation of cerebral and renal arteries: role of the endothelium. (Harder DR, Kauser K, Roman RJ, Lombard JH) J Hypertens Suppl 1989 Sep;7(4):S11-5; discussion S16 PMID: 2809804 09/01/1989
  • [Lymphomatoid papulosis resembling ecthyma. A case report]. (Harder D, Kuhn A, Mahrle G) Z Hautkr 1989 Jul 15;64(7):593-5 PMID: 2528243 07/15/1989
  • Pressure releases a transferable endothelial contractile factor in cat cerebral arteries. (Harder DR, Sanchez-Ferrer C, Kauser K, Stekiel WJ, Rubanyi GM) Circ Res 1989 Jul;65(1):193-8 PMID: 2661050 07/01/1989
  • Mechanism of action of EDRF on pressurized arteries: effect on K+ conductance. (Kauser K, Stekiel WJ, Rubanyi G, Harder DR) Circ Res 1989 Jul;65(1):199-204 PMID: 2786773 07/01/1989
  • Pressure-dependent contraction of rat juxtamedullary afferent arterioles. (Sanchez-Ferrer CF, Roman RJ, Harder DR) Circ Res 1989 Apr;64(4):790-8 PMID: 2702737 04/01/1989
  • Increased sensitivity of cat cerebral arteries to serotonin upon elevation of transmural pressure. (Harder DR) Pflugers Arch 1988 Jun;411(6):698-700 PMID: 3412871 06/01/1988
  • Early effects of experimental diabetes on central catecholamine concentrations. (Wesselmann U, Konkol RJ, Roerig DL, Harder DR) Brain Res Bull 1988 May;20(5):651-4 PMID: 3133085 05/01/1988
  • Vascular muscle cell depolarization and activation in renal arteries on elevation of transmural pressure. (Harder DR, Gilbert R, Lombard JH) Am J Physiol 1987 Oct;253(4 Pt 2):F778-81 PMID: 2444115 10/01/1987
  • Possible cellular mechanism for cerebral vasospasm after experimental subarachnoid hemorrhage in the dog. (Harder DR, Dernbach P, Waters A) J Clin Invest 1987 Sep;80(3):875-80 PMID: 2957393 PMCID: PMC442315 09/01/1987
  • Electrical stimulation of the endothelial surface of pressurized cat middle cerebral artery results in TTX-sensitive vasoconstriction. (Harder DR, Madden JA) Circ Res 1987 Jun;60(6):831-6 PMID: 3594755 06/01/1987
  • Distribution of excitatory junction potential amplitude in cat cerebral arteries: examination of its quantal nature and modulation by opiates. (Madden JA, Kalbfleisch JH, Harder DR) J Cell Physiol 1987 May;131(2):262-6 PMID: 2438292 05/01/1987
  • Altered splenic catecholamine concentrations during experimental allergic encephalomyelitis. (Wesselmann U, Konkol RJ, Leo GL, Roerig DL, Harder DR) Pharmacol Biochem Behav 1987 Apr;26(4):851-4 PMID: 3110796 04/01/1987
  • Effect of morphine on electrophysiological properties of circular and longitudinal muscles. (Gilbert RJ, Sarna SK, Harder DR) Am J Physiol 1987 Mar;252(3 Pt 1):G333-8 PMID: 3826373 03/01/1987
  • The effect of alkaline pH and transmural pressure on arterial constriction and membrane potential of hypertensive cerebral arteries. (Smeda JS, Lombard JH, Madden JA, Harder DR) Pflugers Arch 1987 Mar;408(3):239-42 PMID: 3106928 03/01/1987
  • Pressure-induced myogenic activation of cat cerebral arteries is dependent on intact endothelium. (Harder DR) Circ Res 1987 Jan;60(1):102-7 PMID: 3568282 01/01/1987
  • Effect of reduced oxygen availability upon myogenic depolarization and contraction of cat middle cerebral artery. (Lombard JH, Smeda J, Madden JA, Harder DR) Circ Res 1986 Apr;58(4):565-9 PMID: 3698219 04/01/1986
  • Electrophysiological mechanisms of arterial muscle activation: alterations associated with cerebral vasospasm and hypertension. (Harder DR) Prog Clin Biol Res 1986;219:245-63 PMID: 3538027 01/01/1986
  • Vascular smooth muscle transmembrane potentials during hypotensive stress. (Lombard JH, Willems WJ, Harder DR, Stekiel WJ) Circ Shock 1986;18(2):131-40 PMID: 3948338 01/01/1986
  • Vascular smooth muscle membrane potentials in rats with one-kidney, one clip and reduced renal mass-saline hypertension: the influence of a humoral sodium pump inhibitor. (Pamnani MB, Bryant HJ, Harder DR, Haddy FJ) J Hypertens Suppl 1985 Dec;3(3):S29-31 PMID: 2856822 12/01/1985
  • Hypoxic induction of Ca2+-dependent action potentials in small pulmonary arteries of the cat. (Harder DR, Madden JA, Dawson C) J Appl Physiol (1985) 1985 Nov;59(5):1389-93 PMID: 4066569 11/01/1985
  • Altered membrane properties of cerebral vascular smooth muscle following subarachnoid hemorrhage: an electrophysiological study. I. Changes in resting membrane potential (Em) and effect on the electrogenic pump potential contribution to Em. (Waters A, Harder DR) Stroke 1985 Nov-Dec;16(6):990-7 PMID: 2418549 11/01/1985
  • A membrane electrical mechanism for hypoxic vasoconstriction of small pulmonary arteries from cat. (Harder DR, Madden JA, Dawson C) Chest 1985 Oct;88(4 Suppl):233S-235S PMID: 3930164 10/01/1985
  • Enhanced myogenic depolarization in hypertensive cerebral arterial muscle. (Harder DR, Smeda J, Lombard J) Circ Res 1985 Aug;57(2):319-22 PMID: 4017200 08/01/1985
  • Cellular actions of halothane on cat cerebral arterial muscle. (Harder DR, Gradall K, Madden JA, Kampine JP) Stroke 1985 Jul-Aug;16(4):680-3 PMID: 4024180 07/01/1985
  • Hypoxia-induced activation in small isolated pulmonary arteries from the cat. (Madden JA, Dawson CA, Harder DR) J Appl Physiol (1985) 1985 Jul;59(1):113-8 PMID: 4030552 07/01/1985
  • In vivo membrane potentials of smooth muscle cells in the caudal artery of the rat. (Bryant HJ, Harder DR, Pamnani MB, Haddy FJ) Am J Physiol 1985 Jul;249(1 Pt 1):C78-83 PMID: 4014453 07/01/1985
  • Cellular mechanism of force development in cat middle cerebral artery by reduced PCO2. (Harder DR, Madden JA) Pflugers Arch 1985 Apr;403(4):402-6 PMID: 3925432 04/01/1985
  • A cellular mechanism for myogenic regulation of cat cerebral arteries. (Harder DR) Ann Biomed Eng 1985;13(3-4):335-9 PMID: 4037463 01/01/1985
  • Pressure-dependent membrane depolarization in cat middle cerebral artery. (Harder DR) Circ Res 1984 Aug;55(2):197-202 PMID: 6744529 08/01/1984
  • Cellular mechanisms of opiate receptor stimulation in cat middle cerebral artery. (Harder DR, Madden JA) Eur J Pharmacol 1984 Jul 20;102(3-4):411-6 PMID: 6092096 07/20/1984
  • Electrical activation of arterial muscle. (Harder DR, Waters A) Int Rev Cytol 1984;89:137-49 PMID: 6088415 01/01/1984
  • Electromechanical coupling in rat basilar artery in response to morphine. (Waters A, Harder DR) Neurosurgery 1983 Dec;13(6):676-80 PMID: 6657022 12/01/1983
  • Electromechanical coupling in feline basilar artery in response to serotonin. (Harder DR, Waters A) Eur J Pharmacol 1983 Sep 16;93(1-2):95-100 PMID: 6628550 09/16/1983
  • Membrane mechanisms in arterial hypertension. (Harder DR, Hermsmeyer K) Hypertension 1983 Jul-Aug;5(4):404-8 PMID: 6345356 07/01/1983
  • Sodium-potassium pump activity in reduced renal-mass hypertension. (Huot SJ, Pamnani MB, Clough DL, Buggy J, Bryant HJ, Harder DR, Haddy FJ) Hypertension 1983 Mar-Apr;5(2 Pt 2):I94-100 PMID: 6298108 03/01/1983
  • Response of venous membrane potentials to calcium blockade in spontaneous hypertension. (Stekiel WJ, Contney SJ, Lombard JH, Harder DR) Hypertension 1983 Mar-Apr;5(2 Pt 2):I64-9 PMID: 6826229 03/01/1983
  • Heterogeneity of membrane properties in vascular muscle cells from various vascular beds. (Harder DR) Fed Proc 1983 Feb;42(2):253-6 PMID: 6337065 02/01/1983
  • Diatrizoate meglumine-induced dilation of rat basilar artery: an in vitro study. (Schmidek HH, Moreira D, Harder DR) Neurosurgery 1983 Feb;12(2):137-41 PMID: 6835495 02/01/1983
  • Altered membrane electrical properties of smooth muscle cells from small cerebral arteries of hypertensive rats. (Harder DR, Brann L, Halpern W) Blood Vessels 1983;20(3):154-60 PMID: 6831059 01/01/1983
  • Sympathetic supraspinal control of venous membrane potential in spontaneous hypertension in vivo. (Willems WJ, Harder DR, Contney SJ, McCubbin JW, Stekiel WJ) Am J Physiol 1982 Sep;243(3):C101-6 PMID: 7114244 09/01/1982
  • Effect of H+ and elevated PCO2 on membrane electrical properties of rat cerebral arteries. (Harder DR) Pflugers Arch 1982 Aug;394(2):182-5 PMID: 6812018 08/01/1982
  • Effect of methylprednisolone on small vein responses to hemorrhage and norepinephrine. (Harder DR, Stekiel WJ, Lombard JH) Eur J Pharmacol 1982 Jun 16;81(1):163-6 PMID: 7117368 06/16/1982
  • Membrane electrical mechanism of basilar artery constriction and pial artery dilation by norepinephrine. (Harder DR, Abel PW, Hermsmeyer K) Circ Res 1981 Dec;49(6):1237-42 PMID: 7307242 12/01/1981
  • Bepridil blockade of Ca2+-dependent action potentials in vascular smooth muscle of dog coronary artery. (Harder DR, Sperelakis N) J Cardiovasc Pharmacol 1981 Jul-Aug;3(4):906-14 PMID: 6167820 07/01/1981
  • Norepinephrine effect on in situ venous membrane potential in spontaneously hypertensive rats. (Harder DR, Contney SJ, Willems WJ, Stekiel WJ) Am J Physiol 1981 Jun;240(6):H837-42 PMID: 7246748 06/01/1981
  • Membrane activation of smooth muscle from rabbit basilar artery by dopamine. (Harder DR) Pflugers Arch 1981 Jun;390(3):296-8 PMID: 7196031 06/01/1981
  • Effects of propafenone on TEA-induced action potentials in vascular smooth muscle of canine coronary arteries. (Harder DR, Belardinelli L) Experientia 1980 Sep 15;36(9):1082-3 PMID: 7418845 09/15/1980
  • Comparison of electrical properties of middle cerebral and mesenteric artery in cat. (Harder DR) Am J Physiol 1980 Jul;239(1):C23-6 PMID: 7395983 07/01/1980
  • Transmembrane potential and amino acid transport in rat hepatocytes in primary monolayer culture. (Wondergem R, Harder DR) J Cell Physiol 1980 Jul;104(1):53-60 PMID: 7440646 07/01/1980
  • Membrane electrical effects of histamine on vascular smooth muscle of canine coronary artery. (Harder DR) Circ Res 1980 Mar;46(3):372-7 PMID: 7357692 03/01/1980
  • Membrane potential measurements during rat liver regeneration. (Wondergem R, Harder DR) J Cell Physiol 1980 Feb;102(2):193-7 PMID: 7372723 02/01/1980
  • Active vascular smooth muscle tone and venous membrane potentials during hemorrhage. (Stekiel WJ, Willems WJ, Harder DR, Lombard JH) Am J Physiol 1980 Feb;238(2):H144-52 PMID: 7361906 02/01/1980
  • Estrogen receptors and effects of estrogen on membrane electrical properties of coronary vascular smooth muscle. (Harder DR, Coulson PB) J Cell Physiol 1979 Aug;100(2):375-82 PMID: 511949 08/01/1979
  • Action potentials induced in guinea pig arterial smooth muscle by tetraethylammonium. (Harder DR, Sperelakis N) Am J Physiol 1979 Jul;237(1):C75-80 PMID: 464044 07/01/1979
  • Differential effects of adenosine and nitroglycerin on the action potentials of large and small coronary arteries. (Harder DR, Belardinelli L, Sperelakis N, Rubio R, Berne RM) Circ Res 1979 Feb;44(2):176-82 PMID: 104800 02/01/1979
  • Action potential generation in reaggregates of rat aortic smooth muscle cells in primary culture. (Harder DR, Sperelakis N) Blood Vessels 1979;16(4):186-201 PMID: 454857 01/01/1979
  • Membrane electrical properties of vascular smooth muscle from the guinea pig superior mesenteric artery. (Harder DR, Sperelakis N) Pflugers Arch 1978 Dec 28;378(2):111-9 PMID: 569831 12/28/1978
  • [Antigens of the connective tissue. I. Studies of serum proteins in connective tissue]. (Timpl R, Pecker I) Z Immunitatsforsch Allerg Klin Immunol 1967 Apr;132(4):322-34 PMID: 4232417 04/01/1967
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