Medical College of Wisconsin
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Elizabeth R. Jacobs MD

Elizabeth R. Jacobs MD

Associate Dean, Professor

Institution: Medical College of Wisconsin
Department: Medicine
Division: Pulmonary
Program: Research

Member of the Cancer Center
Member of the Cardiovascular Center

Research Experience

  • Lung Diseases
  • Pulmonary Circulation
  • Pulmonary Infarction
  • Pulmonary Medicine
  • Respiratory Distress Syndrome, Adult
  • Publications (98)

  • Detection of hydrogen peroxide production in the isolated rat lung using Amplex red. (Audi SH, Friedly N, Dash RK, Beyer AM, Clough AV, Jacobs ER) Free Radic Res 2018 Sep;52(9):1052-1062 PMID: 30175632 PMCID: PMC6298832 SCOPUS ID: 2-s2.0-85054191562 09/04/2018    
  • Integrated computational model of the bioenergetics of isolated lung mitochondria. (Zhang X, Dash RK, Jacobs ER, Camara AKS, Clough AV, Audi SH) PLoS One 2018;13(6):e0197921 PMID: 29889855 PMCID: PMC5995348 SCOPUS ID: 2-s2.0-85048330957 06/12/2018       4 Citations
  • Hyperoxia Causes Mitochondrial Fragmentation in Pulmonary Endothelial Cells by Increasing Expression of Pro-Fission Proteins. (Ma C, Beyer AM, Durand M, Clough AV, Zhu D, Norwood Toro L, Terashvili M, Ebben JD, Hill RB, Audi SH, Medhora M, Jacobs ER) Arterioscler Thromb Vasc Biol 2018 03;38(3):622-635 PMID: 29419407 PMCID: PMC5823793 SCOPUS ID: 2-s2.0-85047900228 02/09/2018       3 Citations
  • Protection by Inhaled Hydrogen Therapy in a Rat Model of Acute Lung Injury can be Tracked in vivo Using Molecular Imaging. (Audi SH, Jacobs ER, Zhang X, Camara AKS, Zhao M, Medhora MM, Rizzo B, Clough AV) Shock 2017 10;48(4):467-476 PMID: 28915216 PMCID: PMC5636640 SCOPUS ID: 2-s2.0-85017424389 09/16/2017       6 Citations
  • Impact of duration of hypotension prior to norepinephrine initiation in medical intensive care unit patients with septic shock: A prospective observational study. (Patel JJ, Kurman JS, Biesboer A, Taha H, Katz M, Szabo A, Simpson SQ, Jacobs ER) J Crit Care 2017 08;40:178-183 PMID: 28412642 SCOPUS ID: 2-s2.0-85020732693 04/17/2017       2 Citations
  • Changes in miRNA in the lung and whole blood after whole thorax irradiation in rats. (Gao F, Liu P, Narayanan J, Yang M, Fish BL, Liu Y, Liang M, Jacobs ER, Medhora M) Sci Rep 2017 03 17;7:44132 PMID: 28303893 PMCID: PMC5355888 SCOPUS ID: 2-s2.0-85015404996 03/18/2017       7 Citations
  • Combined Hydration and Antibiotics with Lisinopril to Mitigate Acute and Delayed High-dose Radiation Injuries to Multiple Organs. (Fish BL, Gao F, Narayanan J, Bergom C, Jacobs ER, Cohen EP, Moulder JE, Orschell CM, Medhora M) Health Phys 2016 11;111(5):410-9 PMID: 27682899 PMCID: PMC5065284 SCOPUS ID: 2-s2.0-84991056212 09/30/2016       15 Citations
  • Biomarkers for Radiation Pneumonitis Using Noninvasive Molecular Imaging. (Medhora M, Haworth S, Liu Y, Narayanan J, Gao F, Zhao M, Audi S, Jacobs ER, Fish BL, Clough AV) J Nucl Med 2016 08;57(8):1296-301 PMID: 27033892 PMCID: PMC5053021 SCOPUS ID: 2-s2.0-84982816391 04/02/2016       13 Citations
  • 99MTc-Hexamethylpropyleneamine Oxime Imaging for Early Detection of Acute Lung Injury in Rats Exposed to Hyperoxia or Lipopolysaccharide Treatment. (Audi SH, Clough AV, Haworth ST, Medhora M, Ranji M, Densmore JC, Jacobs ER) Shock 2016 10;46(4):420-30 PMID: 26974426 PMCID: PMC5014734 SCOPUS ID: 2-s2.0-84961231173 03/15/2016       5 Citations
  • Involvement of gap junctions between smooth muscle cells in sustained hypoxic pulmonary vasoconstriction development: a potential role for 15-HETE and 20-HETE. (Kizub IV, Lakhkar A, Dhagia V, Joshi SR, Jiang H, Wolin MS, Falck JR, Koduru SR, Errabelli R, Jacobs ER, Schwartzman ML, Gupte SA) Am J Physiol Lung Cell Mol Physiol 2016 04 15;310(8):L772-83 PMID: 26895643 PMCID: PMC4836112 SCOPUS ID: 2-s2.0-84984605076 02/21/2016       6 Citations
  • Novel Flurometric Tool to Assess Mitochondrial Redox State of Isolated Perfused Rat Lungs after Exposure to Hyperoxia. (Sepehr R, Audi SH, Staniszewski KS, Haworth ST, Jacobs ER, Ranji M) IEEE J Transl Eng Health Med 2013 Oct 16;1 PMID: 25379360 PMCID: PMC4219590 11/08/2014    
  • Whole-thorax irradiation induces hypoxic respiratory failure, pleural effusions and cardiac remodeling. (Medhora M, Gao F, Glisch C, Narayanan J, Sharma A, Harmann LM, Lawlor MW, Snyder LA, Fish BL, Down JD, Moulder JE, Strande JL, Jacobs ER) J Radiat Res 2015 Mar;56(2):248-60 PMID: 25368342 PMCID: PMC4380043 SCOPUS ID: 2-s2.0-84942308898 11/05/2014       19 Citations
  • Model development and use of ACE inhibitors for preclinical mitigation of radiation-induced injury to multiple organs. (Medhora M, Gao F, Wu Q, Molthen RC, Jacobs ER, Moulder JE, Fish BL) Radiat Res 2014 Nov;182(5):545-55 PMID: 25361399 PMCID: PMC4261643 SCOPUS ID: 2-s2.0-84914166194 11/02/2014       17 Citations
  • Early Trophic Enteral Nutrition Is Associated With Improved Outcomes in Mechanically Ventilated Patients With Septic Shock: A Retrospective Review. (Patel JJ, Kozeniecki M, Biesboer A, Peppard W, Ray AS, Thomas S, Jacobs ER, Nanchal R, Kumar G) J Intensive Care Med 2016 Aug;31(7):471-7 PMID: 25315218 SCOPUS ID: 2-s2.0-84978069680 10/16/2014       15 Citations
  • In vivo detection of hyperoxia-induced pulmonary endothelial cell death using (99m)Tc-duramycin. (Audi SH, Jacobs ER, Zhao M, Roerig DL, Haworth ST, Clough AV) Nucl Med Biol 2015 Jan;42(1):46-52 PMID: 25218023 PMCID: PMC4383294 SCOPUS ID: 2-s2.0-84920487394 09/15/2014       15 Citations
  • Enhanced survival from radiation pneumonitis by combined irradiation to the skin. (Gao F, Fish BL, Szabo A, Schock A, Narayanan J, Jacobs ER, Moulder JE, Lazarova Z, Medhora M) Int J Radiat Biol 2014 Sep;90(9):753-61 PMID: 24827855 PMCID: PMC4380176 SCOPUS ID: 2-s2.0-84907045554 05/16/2014       5 Citations
  • Hypoxia preconditioning increases survival and decreases expression of Toll-like receptor 4 in pulmonary artery endothelial cells exposed to lipopolysaccharide. (Ali I, Nanchal R, Husnain F, Audi S, Konduri GG, Densmore JC, Medhora M, Jacobs ER) Pulm Circ 2013 Sep;3(3):578-88 PMID: 24618542 PMCID: PMC4070795 03/13/2014    
  • Clinical CVVH model removes endothelium-derived microparticles from circulation. (Abdelhafeez AH, Jeziorczak PM, Schaid TR, Hoefs SL, Kaul S, Nanchal R, Jacobs ER, Densmore JC) J Extracell Vesicles 2014;3 PMID: 24596654 PMCID: PMC3938801 03/07/2014    
  • The association of lacking insurance with outcomes of severe sepsis: retrospective analysis of an administrative database*. (Kumar G, Taneja A, Majumdar T, Jacobs ER, Whittle J, Nanchal R, Milwaukee Initiative in Critical Care Outcomes Research (MICCOR) Group of Investigators) Crit Care Med 2014 Mar;42(3):583-91 PMID: 24152590 PMCID: PMC4990450 SCOPUS ID: 2-s2.0-84894481253 10/25/2013       21 Citations
  • Enalapril mitigates radiation-induced pneumonitis and pulmonary fibrosis if started 35 days after whole-thorax irradiation. (Gao F, Fish BL, Moulder JE, Jacobs ER, Medhora M) Radiat Res 2013 Nov;180(5):546-52 PMID: 24131041 PMCID: PMC3895940 10/18/2013    
  • Utilization of mechanical ventilation for asthma exacerbations: analysis of a national database. (Nanchal R, Kumar G, Majumdar T, Taneja A, Patel J, Dagar G, Jacobs ER, Whittle J) Respir Care 2014 May;59(5):644-53 PMID: 24106317 PMCID: PMC4580276 SCOPUS ID: 2-s2.0-84899740023 10/10/2013       22 Citations
  • Enalapril mitigates focal alveolar lesions, a histological marker of late pulmonary injury by radiation to the lung. (Gao F, Narayanan J, Joneikis C, Fish BL, Szabo A, Moulder JE, Molthen RC, Jacobs ER, Rao RN, Medhora M) Radiat Res 2013 Apr;179(4):465-74 PMID: 23480564 PMCID: PMC3697111 SCOPUS ID: 2-s2.0-84876241819 03/14/2013       11 Citations
  • Rattus model utilizing selective pulmonary ischemia induces bronchiolitis obliterans organizing pneumonia. (Densmore JC, Jeziorczak PM, Clough AV, Pritchard KA Jr, Cummens B, Medhora M, Rao A, Jacobs ER) Shock 2013 Mar;39(3):271-7 PMID: 23364425 PMCID: PMC3578046 SCOPUS ID: 2-s2.0-84874256858 02/01/2013       7 Citations
  • Outcomes of morbidly obese patients receiving invasive mechanical ventilation: a nationwide analysis. (Kumar G, Majumdar T, Jacobs ER, Danesh V, Dagar G, Deshmukh A, Taneja A, Nanchal R, from the Milwaukee Initiative in Critical Care Outcomes Research (MICCOR) Group of Investigators) Chest 2013 Jul;144(1):48-54 PMID: 23349057 PMCID: PMC4694107 01/26/2013    
  • Surface fluorescence studies of tissue mitochondrial redox state in isolated perfused rat lungs. (Staniszewski K, Audi SH, Sepehr R, Jacobs ER, Ranji M) Ann Biomed Eng 2013 Apr;41(4):827-36 PMID: 23238793 PMCID: PMC3606690 SCOPUS ID: 2-s2.0-84876466897 12/15/2012       12 Citations
  • Short-term treatment with a SOD/catalase mimetic, EUK-207, mitigates pneumonitis and fibrosis after single-dose total-body or whole-thoracic irradiation. (Gao F, Fish BL, Szabo A, Doctrow SR, Kma L, Molthen RC, Moulder JE, Jacobs ER, Medhora M) Radiat Res 2012 Nov;178(5):468-80 PMID: 23020094 PMCID: PMC3678766 SCOPUS ID: 2-s2.0-84868620912 10/02/2012       28 Citations
  • Mitigation of radiation induced pulmonary vascular injury by delayed treatment with captopril. (Molthen RC, Wu Q, Fish BL, Moulder JE, Jacobs ER, Medhora MM) Respirology 2012 Nov;17(8):1261-8 PMID: 22882664 PMCID: PMC3848310 SCOPUS ID: 2-s2.0-84867930386 08/14/2012       19 Citations
  • Acute effects of prostaglandin E1 and E2 on vascular reactivity and blood flow in situ in the chick chorioallantoic membrane. (Harland DR, Lorenz LD, Fay K, Dunn BE, Gruenloh SK, Narayanan J, Jacobs ER, Medhora M) Prostaglandins Leukot Essent Fatty Acids 2012 Aug-Sep;87(2-3):79-89 PMID: 22858445 PMCID: PMC3839254 SCOPUS ID: 2-s2.0-84865387236 08/04/2012       1 Citation
  • Dose-modifying factor for captopril for mitigation of radiation injury to normal lung. (Medhora M, Gao F, Fish BL, Jacobs ER, Moulder JE, Szabo A) J Radiat Res 2012 Jul;53(4):633-40 PMID: 22843631 PMCID: PMC3393339 SCOPUS ID: 2-s2.0-84872114086 07/31/2012       24 Citations
  • Tissue protection and endothelial cell signaling by 20-HETE analogs in intact ex vivo lung slices. (Jacobs ER, Bodiga S, Ali I, Falck AM, Falck JR, Medhora M, Dhanasekaran A) Exp Cell Res 2012 Oct 01;318(16):2143-52 PMID: 22687879 PMCID: PMC3749092 06/13/2012    
  • Optical imaging of tissue mitochondrial redox state in intact rat lungs in two models of pulmonary oxidative stress. (Sepehr R, Staniszewski K, Maleki S, Jacobs ER, Audi S, Ranji M) J Biomed Opt 2012 Apr;17(4):046010 PMID: 22559688 PMCID: PMC3380956 SCOPUS ID: 2-s2.0-84865605652 05/09/2012       28 Citations
  • Pulmonary embolism: the weekend effect. (Nanchal R, Kumar G, Taneja A, Patel J, Deshmukh A, Tarima S, Jacobs ER, Whittle J, from the Milwaukee Initiative in Critical Care Outcomes Research (MICCOR) Group of Investigators) Chest 2012 Sep;142(3):690-696 PMID: 22459777 PMCID: PMC4694190 SCOPUS ID: 2-s2.0-84865851848 03/31/2012       51 Citations
  • A soluble epoxide hydrolase inhibitor--8-HUDE increases pulmonary vasoconstriction through inhibition of K(ATP) channels. (Liu Y, Zhang J, Yu L, Cao F, Rao J, Li J, Jiang C, Falck JR, Jacobs ER, Zhu D) Pulm Pharmacol Ther 2012 Feb;25(1):69-76 PMID: 22155000 SCOPUS ID: 2-s2.0-84856780301 12/14/2011       4 Citations
  • Protection by 20-5,14-HEDGE against surgically induced ischemia reperfusion lung injury in rats. (Ali I, Gruenloh S, Gao Y, Clough A, Falck JR, Medhora M, Jacobs ER) Ann Thorac Surg 2012 Jan;93(1):282-8 PMID: 22115333 PMCID: PMC3268555 SCOPUS ID: 2-s2.0-84055189348 11/26/2011       15 Citations
  • Radiation damage to the lung: mitigation by angiotensin-converting enzyme (ACE) inhibitors. (Medhora M, Gao F, Jacobs ER, Moulder JE) Respirology 2012 Jan;17(1):66-71 PMID: 22023053 PMCID: PMC3245332 SCOPUS ID: 2-s2.0-84255176558 10/26/2011       46 Citations
  • Stable EET urea agonist and soluble epoxide hydrolase inhibitor regulate rat pulmonary arteries through TRPCs. (Liu Y, Wang R, Li J, Rao J, Li W, Falck JR, Manthati VL, Medhora M, Jacobs ER, Zhu D) Hypertens Res 2011 May;34(5):630-9 PMID: 21307870 PMCID: PMC4548928 SCOPUS ID: 2-s2.0-79955600318 02/11/2011       13 Citations
  • Mechanisms underlying increased reactivity of pulmonary arteries contralateral to a localized high-flow anastomosis. (Pfister S, Somberg L, Lowry T, Gao Y, Medhora M, Jacobs ER) J Thorac Cardiovasc Surg 2011 Feb;141(2):425-31 PMID: 21075383 PMCID: PMC3052931 SCOPUS ID: 2-s2.0-78751601116 11/16/2010       1 Citation
  • Effects of a localized high-flow anastomosis between the aorta and left lower lobe pulmonary artery on great vessel flow and pulmonary arterial reactivity in the contralateral lung. (Somberg L, Nirula R, Bousamra M 2nd, Friesema J, Zhu D, Medhora M, Jacobs ER) J Thorac Cardiovasc Surg 2011 Feb;141(2):407-12 PMID: 21075384 PMCID: PMC3022966 SCOPUS ID: 2-s2.0-78751591713 11/16/2010       1 Citation
  • 8,9-Epoxyeicosatrienoic acid analog protects pulmonary artery smooth muscle cells from apoptosis via ROCK pathway. (Ma J, Zhang L, Li S, Liu S, Ma C, Li W, Falck JR, Manthati VL, Reddy DS, Medhora M, Jacobs ER, Zhu D) Exp Cell Res 2010 Aug 15;316(14):2340-53 PMID: 20493836 PMCID: PMC2927814 05/25/2010    
  • Cellular inflammatory infiltrate in pneumonitis induced by a single moderate dose of thoracic x radiation in rats. (Szabo S, Ghosh SN, Fish BL, Bodiga S, Tomic R, Kumar G, Morrow NV, Moulder JE, Jacobs ER, Medhora M) Radiat Res 2010 Apr;173(4):545-56 PMID: 20334527 PMCID: PMC2904484 SCOPUS ID: 2-s2.0-77950256999 03/26/2010       29 Citations
  • 20-HETE-induced nitric oxide production in pulmonary artery endothelial cells is mediated by NADPH oxidase, H2O2, and PI3-kinase/Akt. (Bodiga S, Gruenloh SK, Gao Y, Manthati VL, Dubasi N, Falck JR, Medhora M, Jacobs ER) Am J Physiol Lung Cell Mol Physiol 2010 Apr;298(4):L564-74 PMID: 20061439 PMCID: PMC2853341 SCOPUS ID: 2-s2.0-77950334333 01/12/2010       22 Citations
  • Renin-Angiotensin system suppression mitigates experimental radiation pneumonitis. (Ghosh SN, Zhang R, Fish BL, Semenenko VA, Li XA, Moulder JE, Jacobs ER, Medhora M) Int J Radiat Oncol Biol Phys 2009 Dec 01;75(5):1528-36 PMID: 19931735 PMCID: PMC2800372 SCOPUS ID: 2-s2.0-71649101555 11/26/2009       71 Citations
  • Prolonged hypothermia as a bridge to recovery for cerebral edema and intracranial hypertension associated with fulminant hepatic failure. (Jacob S, Khan A, Jacobs ER, Kandiah P, Nanchal R) Neurocrit Care 2009;11(2):242-6 PMID: 19728177 SCOPUS ID: 2-s2.0-70350575434 09/04/2009       13 Citations
  • Vascular injury after whole thoracic x-ray irradiation in the rat. (Ghosh SN, Wu Q, M├Ąder M, Fish BL, Moulder JE, Jacobs ER, Medhora M, Molthen RC) Int J Radiat Oncol Biol Phys 2009 May 01;74(1):192-9 PMID: 19362237 PMCID: PMC2745917 SCOPUS ID: 2-s2.0-64049089817 04/14/2009       42 Citations
  • Protective actions of epoxyeicosatrienoic acid: dual targeting of cardiovascular PI3K and KATP channels. (Bodiga S, Zhang R, Jacobs DE, Larsen BT, Tampo A, Manthati VL, Kwok WM, Zeldin DC, Falck JR, Gutterman DD, Jacobs ER, Medhora MM) J Mol Cell Cardiol 2009 Jun;46(6):978-88 PMID: 19336274 PMCID: PMC2796716 SCOPUS ID: 2-s2.0-67349200006 04/02/2009       35 Citations
  • 20-HETE increases survival and decreases apoptosis in pulmonary arteries and pulmonary artery endothelial cells. (Dhanasekaran A, Bodiga S, Gruenloh S, Gao Y, Dunn L, Falck JR, Buonaccorsi JN, Medhora M, Jacobs ER) Am J Physiol Heart Circ Physiol 2009 Mar;296(3):H777-86 PMID: 19136601 PMCID: PMC2660237 SCOPUS ID: 2-s2.0-64049113217 01/13/2009       34 Citations
  • Near infrared light protects cardiomyocytes from hypoxia and reoxygenation injury by a nitric oxide dependent mechanism. (Zhang R, Mio Y, Pratt PF, Lohr N, Warltier DC, Whelan HT, Zhu D, Jacobs ER, Medhora M, Bienengraeber M) J Mol Cell Cardiol 2009 Jan;46(1):4-14 PMID: 18930064 PMCID: PMC2640422 SCOPUS ID: 2-s2.0-57149112732 10/22/2008       65 Citations
  • Structural and functional alterations in the rat lung following whole thoracic irradiation with moderate doses: injury and recovery. (Zhang R, Ghosh SN, Zhu D, North PE, Fish BL, Morrow NV, Lowry T, Nanchal R, Jacobs ER, Moulder JE, Medhora M) Int J Radiat Biol 2008 Jun;84(6):487-97 PMID: 18470747 PMCID: PMC2435093 SCOPUS ID: 2-s2.0-45849110724 05/13/2008       40 Citations
  • 20-HETE increases superoxide production and activates NAPDH oxidase in pulmonary artery endothelial cells. (Medhora M, Chen Y, Gruenloh S, Harland D, Bodiga S, Zielonka J, Gebremedhin D, Gao Y, Falck JR, Anjaiah S, Jacobs ER) Am J Physiol Lung Cell Mol Physiol 2008 May;294(5):L902-11 PMID: 18296498 PMCID: PMC2586843 SCOPUS ID: 2-s2.0-45849122077 02/26/2008       50 Citations
  • Role of JNK in network formation of human lung microvascular endothelial cells. (Medhora M, Dhanasekaran A, Pratt PF Jr, Cook CR, Dunn LK, Gruenloh SK, Jacobs ER) Am J Physiol Lung Cell Mol Physiol 2008 Apr;294(4):L676-85 PMID: 18263671 PMCID: PMC2904476 SCOPUS ID: 2-s2.0-42049122785 02/12/2008       15 Citations
  • Multiple antiapoptotic targets of the PI3K/Akt survival pathway are activated by epoxyeicosatrienoic acids to protect cardiomyocytes from hypoxia/anoxia. (Dhanasekaran A, Gruenloh SK, Buonaccorsi JN, Zhang R, Gross GJ, Falck JR, Patel PK, Jacobs ER, Medhora M) Am J Physiol Heart Circ Physiol 2008 Feb;294(2):H724-35 PMID: 18055514 PMCID: PMC2443685 SCOPUS ID: 2-s2.0-39149128273 12/07/2007       123 Citations
  • Emerging mechanisms for growth and protection of the vasculature by cytochrome P450-derived products of arachidonic acid and other eicosanoids. (Medhora M, Dhanasekaran A, Gruenloh SK, Dunn LK, Gabrilovich M, Falck JR, Harder DR, Jacobs ER, Pratt PF) Prostaglandins Other Lipid Mediat 2007 Jan;82(1-4):19-29 PMID: 17164129 SCOPUS ID: 2-s2.0-33845313333 12/14/2006       38 Citations
  • Spontaneous airway hyperresponsiveness in estrogen receptor-alpha-deficient mice. (Carey MA, Card JW, Bradbury JA, Moorman MP, Haykal-Coates N, Gavett SH, Graves JP, Walker VR, Flake GP, Voltz JW, Zhu D, Jacobs ER, Dakhama A, Larsen GL, Loader JE, Gelfand EW, Germolec DR, Korach KS, Zeldin DC) Am J Respir Crit Care Med 2007 Jan 15;175(2):126-35 PMID: 17095746 PMCID: PMC1899278 SCOPUS ID: 2-s2.0-33846286093 11/11/2006       78 Citations
  • Contribution of epoxyeicosatrienoic acids to the hypoxia-induced activation of Ca2+ -activated K+ channel current in cultured rat hippocampal astrocytes. (Yamaura K, Gebremedhin D, Zhang C, Narayanan J, Hoefert K, Jacobs ER, Koehler RC, Harder DR) Neuroscience 2006 Dec;143(3):703-16 PMID: 17027168 SCOPUS ID: 2-s2.0-33750978403 10/10/2006       37 Citations
  • VEGF-induced relaxation of pulmonary arteries is mediated by endothelial cytochrome P-450 hydroxylase. (Jacobs ER, Zhu D, Gruenloh S, Lopez B, Medhora M) Am J Physiol Lung Cell Mol Physiol 2006 Sep;291(3):L369-77 PMID: 16679379 SCOPUS ID: 2-s2.0-33748435644 05/09/2006       25 Citations
  • Mechanisms of activation of eNOS by 20-HETE and VEGF in bovine pulmonary artery endothelial cells. (Chen Y, Medhora M, Falck JR, Pritchard KA Jr, Jacobs ER) Am J Physiol Lung Cell Mol Physiol 2006 Sep;291(3):L378-85 PMID: 16679377 SCOPUS ID: 2-s2.0-33748439111 05/09/2006       44 Citations
  • Protective effects of epoxyeicosatrienoic acids on human endothelial cells from the pulmonary and coronary vasculature. (Dhanasekaran A, Al-Saghir R, Lopez B, Zhu D, Gutterman DD, Jacobs ER, Medhora M) Am J Physiol Heart Circ Physiol 2006 Aug;291(2):H517-31 PMID: 16617127 SCOPUS ID: 2-s2.0-33746790148 04/18/2006       54 Citations
  • Chick chorioallantoic membrane as an in vivo model to study vasoreactivity: characterization of development-dependent hyperemia induced by epoxyeicosatrienoic acids (EETs). (Dunn LK, Gruenloh SK, Dunn BE, Reddy DS, Falck JR, Jacobs ER, Medhora M) Anat Rec A Discov Mol Cell Evol Biol 2005 Aug;285(2):771-80 PMID: 15952186 SCOPUS ID: 2-s2.0-23244463577 06/14/2005       12 Citations
  • P2Y purine receptor responses and expression in the pulmonary circulation of juvenile rabbits. (Konduri GG, Bakhutashvili I, Frenn R, Chandrasekhar I, Jacobs ER, Khanna AK) Am J Physiol Heart Circ Physiol 2004 Jul;287(1):H157-64 PMID: 14962841 SCOPUS ID: 2-s2.0-1942498685 02/14/2004       23 Citations
  • Increased epoxyeicosatrienoic acid formation in the rat kidney during liver cirrhosis. (Miyazono M, Zhu D, Nemenoff R, Jacobs ER, Carter EP) J Am Soc Nephrol 2003 Jul;14(7):1766-75 PMID: 12819236 SCOPUS ID: 2-s2.0-0037530612 06/24/2003       9 Citations
  • Chronic hypoxia activates lung 15-lipoxygenase, which catalyzes production of 15-HETE and enhances constriction in neonatal rabbit pulmonary arteries. (Zhu D, Medhora M, Campbell WB, Spitzbarth N, Baker JE, Jacobs ER) Circ Res 2003 May 16;92(9):992-1000 PMID: 12690037 SCOPUS ID: 2-s2.0-0037687982 04/12/2003       126 Citations
  • Epoxygenase-driven angiogenesis in human lung microvascular endothelial cells. (Medhora M, Daniels J, Mundey K, Fisslthaler B, Busse R, Jacobs ER, Harder DR) Am J Physiol Heart Circ Physiol 2003 Jan;284(1):H215-24 PMID: 12388259 SCOPUS ID: 2-s2.0-0037230201 10/22/2002       94 Citations
  • Nitric oxide contributes to 20-HETE-induced relaxation of pulmonary arteries. (Yu M, McAndrew RP, Al-Saghir R, Maier KG, Medhora M, Roman RJ, Jacobs ER) J Appl Physiol (1985) 2002 Oct;93(4):1391-9 PMID: 12235040 SCOPUS ID: 2-s2.0-0036785969 09/18/2002       34 Citations
  • Serotonin and serotonin receptor expression in the aorta of carotid intact and denervated newborns. (Serra A, Brozoski D, Simeon T, Yi J, Bastasic J, Franciosi R, Jacobs ER, Forster HV) Respir Physiol Neurobiol 2002 Sep 04;132(3):253-64 PMID: 12208084 SCOPUS ID: 2-s2.0-0037019778 09/05/2002       7 Citations
  • CYP4A mRNA, protein, and product in rat lungs: novel localization in vascular endothelium. (Zhu D, Zhang C, Medhora M, Jacobs ER) J Appl Physiol (1985) 2002 Jul;93(1):330-7 PMID: 12070222 SCOPUS ID: 2-s2.0-0035986058 06/19/2002       50 Citations
  • Upregulation of collagens detected by gene array in a model of flow-induced pulmonary vascular remodeling. (Medhora M, Bousamra M 2nd, Zhu D, Somberg L, Jacobs ER) Am J Physiol Heart Circ Physiol 2002 Feb;282(2):H414-22 PMID: 11788387 SCOPUS ID: 2-s2.0-0036084720 01/15/2002       37 Citations
  • The lung HETEs (and EETs) up. (Jacobs ER, Zeldin DC) Am J Physiol Heart Circ Physiol 2001 Jan;280(1):H1-H10 PMID: 11123211 SCOPUS ID: 2-s2.0-0035013924 12/21/2000       66 Citations
  • Hypoxic pulmonary vasoconstriction is modified by P-450 metabolites. (Zhu D, Birks EK, Dawson CA, Patel M, Falck JR, Presberg K, Roman RJ, Jacobs ER) Am J Physiol Heart Circ Physiol 2000 Oct;279(4):H1526-33 PMID: 11009437 SCOPUS ID: 2-s2.0-34447616694 09/29/2000       9 Citations
  • Response of the lungs to aspiration. (Effros RM, Jacobs ER, Schapira RM, Biller J) Am J Med 2000 Mar 06;108 Suppl 4a:15S-19S PMID: 10718446 SCOPUS ID: 2-s2.0-0034611349 03/16/2000       18 Citations
  • Epoxyeicosatrienoic acids constrict isolated pressurized rabbit pulmonary arteries. (Zhu D, Bousamra M 2nd, Zeldin DC, Falck JR, Townsley M, Harder DR, Roman RJ, Jacobs ER) Am J Physiol Lung Cell Mol Physiol 2000 Feb;278(2):L335-43 PMID: 10666118 SCOPUS ID: 2-s2.0-0034014269 02/09/2000       77 Citations
  • Increasing airway pressures can promote transvascular edema reabsorption. (Effros RM, Jacobs ER, Schapira RM, Lin W, Presberg K) Chest 1999 Jul;116(1 Suppl):30S-31S PMID: 10424574 SCOPUS ID: 2-s2.0-0032779708 07/29/1999       3 Citations
  • Effects of chronic pulmonary overcirculation on pulmonary vasomotor tone. (Parviz M, Bousamra M 2nd, Chammas JH, Birks EK, Presberg KW, Jacobs ER, Nelin LD) Ann Thorac Surg 1999 Feb;67(2):522-7 PMID: 10197682 SCOPUS ID: 2-s2.0-0032929882 04/10/1999       21 Citations
  • Airway synthesis of 20-hydroxyeicosatetraenoic acid: metabolism by cyclooxygenase to a bronchodilator. (Jacobs ER, Effros RM, Falck JR, Reddy KM, Campbell WB, Zhu D) Am J Physiol 1999 02;276(2):L280-8 PMID: 9950890 SCOPUS ID: 2-s2.0-0032991405 02/10/1999       33 Citations
  • Stop-flow studies of solute uptake in rat lungs. (Effros RM, Schapira R, Presberg K, Ozker K, Jacobs ER) J Appl Physiol (1985) 1998 Sep;85(3):986-92 PMID: 9729574 SCOPUS ID: 2-s2.0-0031666140 09/08/1998       5 Citations
  • Tissue sources of cytochrome P450 4A and 20-HETE synthesis in rabbit lungs. (Zhu D, Effros RM, Harder DR, Roman RJ, Jacobs ER) Am J Respir Cell Mol Biol 1998 Jul;19(1):121-8 PMID: 9651188 SCOPUS ID: 2-s2.0-0032111675 07/03/1998       39 Citations
  • Cat cerebral arterial smooth muscle cells express cytochrome P450 4A2 enzyme and produce the vasoconstrictor 20-HETE which enhances L-type Ca2+ current. (Gebremedhin D, Lange AR, Narayanan J, Aebly MR, Jacobs ER, Harder DR) J Physiol 1998 Mar 15;507 ( Pt 3):771-81 PMID: 9508838 PMCID: PMC2230829 SCOPUS ID: 2-s2.0-0032521122 05/23/1998       158 Citations
  • Water transport and the distribution of aquaporin-1 in pulmonary air spaces. (Effros RM, Darin C, Jacobs ER, Rogers RA, Krenz G, Schneeberger EE) J Appl Physiol (1985) 1997 Sep;83(3):1002-16 PMID: 9292489 SCOPUS ID: 2-s2.0-0030770795 09/18/1997       41 Citations
  • Human pulmonary arteries dilate to 20-HETE, an endogenous eicosanoid of lung tissue. (Birks EK, Bousamra M, Presberg K, Marsh JA, Effros RM, Jacobs ER) Am J Physiol 1997 May;272(5 Pt 1):L823-9 PMID: 9176244 SCOPUS ID: 2-s2.0-0030914663 05/01/1997       57 Citations
  • Stereospecific effects of epoxyeicosatrienoic acids on renal vascular tone and K(+)-channel activity. (Zou AP, Fleming JT, Falck JR, Jacobs ER, Gebremedhin D, Harder DR, Roman RJ) Am J Physiol 1996 May;270(5 Pt 2):F822-32 PMID: 8928844 05/01/1996       179 Citations
  • Coexistence of two types of Ca(2+)-activated K+ channels in rat renal arterioles. (Gebremedhin D, Kaldunski M, Jacobs ER, Harder DR, Roman RJ) Am J Physiol 1996 Jan;270(1 Pt 2):F69-81 PMID: 8769824 SCOPUS ID: 2-s2.0-0030062899 01/01/1996       79 Citations
  • 20-HETE is an endogenous inhibitor of the large-conductance Ca(2+)-activated K+ channel in renal arterioles. (Zou AP, Fleming JT, Falck JR, Jacobs ER, Gebremedhin D, Harder DR, Roman RJ) Am J Physiol 1996 Jan;270(1 Pt 2):R228-37 PMID: 8769806 SCOPUS ID: 2-s2.0-0030029461 01/01/1996       260 Citations
  • Shear activated channels in cell-attached patches of cultured bovine aortic endothelial cells. (Jacobs ER, Cheliakine C, Gebremedhin D, Birks EK, Davies PF, Harder DR) Pflugers Arch 1995 Nov;431(1):129-31 PMID: 8584410 SCOPUS ID: 2-s2.0-0028840911 11/01/1995       71 Citations
  • pH-induced calcium transients in type II alveolar epithelial cells. (Gerboth GD, Effros RM, Roman RJ, Jacobs ER) Am J Physiol 1993 May;264(5 Pt 1):L448-57 PMID: 8498523 SCOPUS ID: 2-s2.0-0027174969 05/01/1993       21 Citations
  • Benign bone lesions simulating metastases on Tc-99m diphosphonate imaging. (Sweeney DC, Greenberg JS, McAfee JG, Jacobs ER) Clin Nucl Med 1992 Feb;17(2):134-6 PMID: 1563184 02/01/1992       2 Citations
  • Mechanisms of potassium channel block in rat alveolar epithelial cells. (Jacobs ER, DeCoursey TE) J Pharmacol Exp Ther 1990 Nov;255(2):459-72 PMID: 1700814 SCOPUS ID: 2-s2.0-0025222445 11/01/1990       42 Citations
  • Ion channels in the metabolic regulation of respiratory cells. (Jacobs ER, DeCoursey TE) Clin Chest Med 1989 Mar;10(1):25-36 PMID: 2468439 SCOPUS ID: 2-s2.0-0024600088 03/01/1989       2 Citations
  • Potassium currents in rat type II alveolar epithelial cells. (DeCoursey TE, Jacobs ER, Silver MR) J Physiol 1988 Jan;395:487-505 PMID: 2457683 PMCID: PMC1192006 SCOPUS ID: 2-s2.0-0023852692 01/01/1988       47 Citations
  • Incidence of aspiration in tracheally intubated adults. (Elpern EH, Jacobs ER, Bone RC) Heart Lung 1987 Sep;16(5):527-31 PMID: 3115917 SCOPUS ID: 2-s2.0-0023247378 09/01/1987       87 Citations
  • Increased hemodynamic and survival with endotoxin and septic shock with ibuprofen treatment. (Bone RC, Jacobs ER, Wilson FJ Jr) Prog Clin Biol Res 1987;236A:327-32 PMID: 3303045 SCOPUS ID: 2-s2.0-0023064964 01/01/1987       4 Citations
  • Clinical indicators in sepsis and septic adult respiratory distress syndrome. (Jacobs ER, Bone RC) Med Clin North Am 1986 Jul;70(4):921-32 PMID: 3520186 SCOPUS ID: 2-s2.0-0022517206 07/01/1986       20 Citations
  • Therapeutic implications of acute lung injury. (Jacobs ER, Bone RC) Crit Care Clin 1986 Jul;2(3):615-28 PMID: 3331566 SCOPUS ID: 2-s2.0-0022966575 07/01/1986       2 Citations
  • Pseudomembranous colitis & antibiotics. (Goodpasture HC, Dolan PJ Jr, Jacobs ER, Meredith WT) Kans Med 1986 May;87(5):133, 146 PMID: 3712916 05/01/1986       7 Citations
  • Immunoglobulin G-induced single ionic channels in human alveolar macrophage membranes. (Nelson DJ, Jacobs ER, Tang JM, Zeller JM, Bone RC) J Clin Invest 1985 Aug;76(2):500-7 PMID: 2411759 PMCID: PMC423851 08/01/1985    
  • Research on ibuprofen for sepsis and respiratory failure. (Bone RC, Jacobs ER) Am J Med 1984 Jul 13;77(1A):114-20 PMID: 6431806 SCOPUS ID: 2-s2.0-0021147078 07/13/1984       7 Citations
  • Protection of myocardial function during endotoxin shock by ibuprofen. (Soulsby ME, Jacobs ER, Perlmutter BH, Bone RC) Prostaglandins Leukot Med 1984 Mar;13(3):295-305 PMID: 6585848 SCOPUS ID: 2-s2.0-0021323198 03/01/1984       13 Citations
  • Mediators of septic lung injury. (Jacobs ER, Bone RC) Med Clin North Am 1983 May;67(3):701-15 PMID: 6302411 SCOPUS ID: 2-s2.0-0020538450 05/01/1983       14 Citations
  • Ibuprofen in canine endotoxin shock. (Jacobs ER, Soulsby ME, Bone RC, Wilson FJ Jr, Hiller FC) J Clin Invest 1982 Sep;70(3):536-41 PMID: 7107893 PMCID: PMC370254 09/01/1982    
  • Why qualifications; school nurses (teachers of health and hygiene?). (JACOBS ER) Mon Bull Indiana State Board Health 1946 Sep;49(9):207 PMID: 20278086 09/01/1946    
  • Last update: 06/27/2019
    jenkins-FCD Prod-410 e9586552fe7f53c71f7923aa6e27aeabbd3c2473