Medical College of Wisconsin
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Howard J. Jacob PhD

Howard J. Jacob PhD

Center Director, Professor

Institution: Medical College of Wisconsin
Department: Physiology
Program: Genetics

Member of the Cancer Center


Publications

  • Characterization of human plasma-derived exosomal RNAs by deep sequencing. (Huang X, Yuan T, Tschannen M, Sun Z, Jacob H, Du M, Liang M, Dittmar RL, Liu Y, Liang M, Kohli M, Thibodeau SN, Boardman L, Wang L) BMC Genomics 2013;14:319 PMID: 23663360 PMCID: PMC3653748
  • Identification of somatic mutations in non-small cell lung carcinomas using whole-exome sequencing. (Liu P, Morrison C, Wang L, Xiong D, Vedell P, Cui P, Hua X, Ding F, Lu Y, James M, Ebben JD, Xu H, Adjei AA, Head K, Andrae JW, Tschannen MR, Jacob H, Pan J, Zhang Q, Van den Bergh F, Xiao H, Lo KC, Patel J, Richmond T, Watt MA, Albert T, Selzer R, Anderson M, Wang J, Wang Y, Starnes S, Yang P, You M) Carcinogenesis 2012 Jul;33(7):1270-6 PMID: 22510280 PMCID: PMC3499051
  • Characterization of the genomic structure and function of regions influencing renin and angiogenesis in the SS rat. (Stodola TJ, de Resende MM, Sarkis AB, Didier DN, Jacob HJ, Huebner N, Hummel O, Saar K, Moreno C, Greene AS) Physiol Genomics 2011 Jul 14;43(13):808-17 PMID: 21521778 PMCID: PMC3132840
  • Refined mapping of the renal failure RF-3 quantitative trait locus. (O'Meara CC, Lazar J, Hoffman M, Moreno C, Jacob HJ) J Am Soc Nephrol 2011 Mar;22(3):518-25 PMID: 21127141 PMCID: PMC3060445
  • Identification of novel carcinogen-mediated mammary tumor susceptibility loci in the rat using the chromosome substitution technique. (Adamovic T, McAllister D, Wang T, Adamovic D, Rowe JJ, Moreno C, Lazar J, Jacob HJ, Sugg SL) Genes Chromosomes Cancer 2010 Nov;49(11):1035-45 PMID: 20737482 PMCID: PMC2943010
  • Rats! (Iannaccone PM, Jacob HJ) Dis Model Mech 2009 May-Jun;2(5-6):206-10 PMID: 19407324 PMCID: PMC2675817
  • Congenic strains provide evidence that four mapped loci in chromosomes 2, 4, and 16 influence hypertension in the SHR. (Aneas I, Rodrigues MV, Pauletti BA, Silva GJ, Carmona R, Cardoso L, Kwitek AE, Jacob HJ, Soler JM, Krieger JE) Physiol Genomics 2009 Mar 3;37(1):52-7 PMID: 19126752
  • The Rat Genome Database 2009: variation, ontologies and pathways. (Dwinell MR, Worthey EA, Shimoyama M, Bakir-Gungor B, DePons J, Laulederkind S, Lowry T, Nigram R, Petri V, Smith J, Stoddard A, Twigger SN, Jacob HJ, RGD Team) Nucleic Acids Res 2009 Jan;37(Database issue):D744-9 PMID: 18996890 PMCID: PMC2686558
  • Genetically hypertensive Brown Norway congenic rat strains suggest intermediate traits underlying genetic hypertension. (Bilusić M, Moreno C, Barreto NE, Tschannen MR, Harris EL, Porteous WK, Thompson CM, Grigor MR, Weder A, Boerwinkle E, Hunt SC, Curb JD, Jacob HJ, Kwitek AE) Croat Med J 2008 Oct;49(5):586-99 PMID: 18925692 PMCID: PMC2582351
  • Transfer of the CYP4A region of chromosome 5 from Lewis to Dahl S rats attenuates renal injury. (Williams JM, Sarkis A, Hoagland KM, Fredrich K, Ryan RP, Moreno C, Lopez B, Lazar J, Fenoy FJ, Sharma M, Garrett MR, Jacob HJ, Roman RJ) Am J Physiol Renal Physiol 2008 Dec;295(6):F1764-77 PMID: 18842817 PMCID: PMC2604826
  • Genetic mapping of mammary tumor traits to rat chromosome 10 using a novel panel of consomic rats. (Adamovic T, McAllister D, Rowe JJ, Wang T, Jacob HJ, Sugg SL) Cancer Genet Cytogenet 2008 Oct;186(1):41-8 PMID: 18786441
  • A joint association test for multiple SNPs in genetic case-control studies. (Wang T, Jacob H, Ghosh S, Wang X, Zeng ZB) Genet Epidemiol 2009 Feb;33(2):151-63 PMID: 18770519 PMCID: PMC2719721
  • Chromosome substitution reveals the genetic basis of Dahl salt-sensitive hypertension and renal disease. (Mattson DL, Dwinell MR, Greene AS, Kwitek AE, Roman RJ, Jacob HJ, Cowley AW Jr) Am J Physiol Renal Physiol 2008 Sep;295(3):F837-42 PMID: 18653478 PMCID: PMC2536867
  • Using multiple ontologies to integrate complex biological data. (Shimoyama M, Petri V, Pasko D, Bromberg S, Wu W, Chen J, Nenasheva N, Kwitek A, Twigger S, Jacob H) Comp Funct Genomics 2005;6(7-8):373-8 PMID: 18629202 PMCID: PMC2447497
  • What everybody should know about the rat genome and its online resources. (Twigger SN, Pruitt KD, Fernández-Suárez XM, Karolchik D, Worley KC, Maglott DR, Brown G, Weinstock G, Gibbs RA, Kent J, Birney E, Jacob HJ) Nat Genet 2008 May;40(5):523-7 PMID: 18443589 PMCID: PMC2505193
  • Progress and prospects in rat genetics: a community view. (Aitman TJ, Critser JK, Cuppen E, Dominiczak A, Fernandez-Suarez XM, Flint J, Gauguier D, Geurts AM, Gould M, Harris PC, Holmdahl R, Hubner N, Izsvák Z, Jacob HJ, Kuramoto T, Kwitek AE, Marrone A, Mashimo T, Moreno C, Mullins J, Mullins L, Olsson T, Pravenec M, Riley L, Saar K, Serikawa T, Shull JD, Szpirer C, Twigger SN, Voigt B, Worley K) Nat Genet 2008 May;40(5):516-22 PMID: 18443588
  • Distribution and functional impact of DNA copy number variation in the rat. (Guryev V, Saar K, Adamovic T, Verheul M, van Heesch SA, Cook S, Pravenec M, Aitman T, Jacob H, Shull JD, Hubner N, Cuppen E) Nat Genet 2008 May;40(5):538-45 PMID: 18443591
  • Molecular networks in Dahl salt-sensitive hypertension based on transcriptome analysis of a panel of consomic rats. (Liang M, Lee NH, Wang H, Greene AS, Kwitek AE, Kaldunski ML, Luu TV, Frank BC, Bugenhagen S, Jacob HJ, Cowley AW Jr) Physiol Genomics 2008 Jun 12;34(1):54-64 PMID: 18430809
  • Comparative genomics for detecting human disease genes. (Moreno C, Lazar J, Jacob HJ, Kwitek AE) Adv Genet 2008;60:655-97 PMID: 18358336
  • Effects of chromosome 17 on features of the metabolic syndrome in the Lyon hypertensive rat. (Gilibert S, Kwitek AE, Hubner N, Tschannen M, Jacob HJ, Sassard J, Bataillard A) Physiol Genomics 2008 Apr 22;33(2):212-7 PMID: 18285521
  • Tissue engineering: a new frontier in physiological genomics. (Petersen MC, Lazar J, Jacob HJ, Wakatsuki T) Physiol Genomics 2007 Dec 19;32(1):28-32 PMID: 17956999
  • Chromosomal mapping of the genetic basis of hypertension and renal disease in FHH rats. (Mattson DL, Dwinell MR, Greene AS, Kwitek AE, Roman RJ, Cowley AW Jr, Jacob HJ) Am J Physiol Renal Physiol 2007 Dec;293(6):F1905-14 PMID: 17898042
  • Multiple blood pressure loci on rat chromosome 13 attenuate development of hypertension in the Dahl S hypertensive rat. (Moreno C, Kaldunski ML, Wang T, Roman RJ, Greene AS, Lazar J, Jacob HJ, Cowley AW Jr) Physiol Genomics 2007 Oct 22;31(2):228-35 PMID: 17566075
  • A locus on chromosome 10 influences C-reactive protein levels in two independent populations. (Broeckel U, Hengstenberg C, Mayer B, Maresso K, Gaudet D, Seda O, Tremblay J, Holmer S, Erdmann J, Glöckner C, Harrison M, Martin LJ, Williams JT, Schmitz G, Riegger GA, Jacob HJ, Hamet P, Schunkert H) Hum Genet 2007 Aug;122(1):95-102 PMID: 17530289
  • Rat survival to anthrax lethal toxin is likely controlled by a single gene. (Nye SH, Wittenburg AL, Evans DL, O'Connor JA, Roman RJ, Jacob HJ) Pharmacogenomics J 2008 Feb;8(1):16-22 PMID: 17440430
  • Efficient transgenic rat production by a lentiviral vector. (Michalkiewicz M, Michalkiewicz T, Geurts AM, Roman RJ, Slocum GR, Singer O, Weihrauch D, Greene AS, Kaldunski M, Verma IM, Jacob HJ, Cowley AW Jr) Am J Physiol Heart Circ Physiol 2007 Jul;293(1):H881-94 PMID: 17322424
  • The Rat Genome Database, update 2007--easing the path from disease to data and back again. (Twigger SN, Shimoyama M, Bromberg S, Kwitek AE, Jacob HJ, RGD Team) Nucleic Acids Res 2007 Jan;35(Database issue):D658-62 PMID: 17151068 PMCID: PMC1761441
  • Comprehensive quality control utilizing the prehybridization third-dye image leads to accurate gene expression measurements by cDNA microarrays. (Wang X, Jia S, Meyer L, Xiang B, Chen LY, Jiang N, Moreno C, Jacob HJ, Ghosh S, Hessner MJ) BMC Bioinformatics 2006;7:378 PMID: 16907976 PMCID: PMC1563483
  • Genetic aspects of the etiology and treatment of asthma. (Meurer JR, Lustig JV, Jacob HJ) Pediatr Clin North Am 2006 Aug;53(4):715-25 PMID: 16873001
  • Dickkopf homologs in squamous mucosa of esophagitis patients are overexpressed compared with Barrett's patients and healthy controls. (Ali I, Rafiee P, Hogan WJ, Jacob HJ, Komorowski RA, Haasler GB, Shaker R) Am J Gastroenterol 2006 Jul;101(7):1437-48 PMID: 16863544
  • Sequence analysis of the complete mitochondrial DNA in 10 commonly used inbred rat strains. (Schlick NE, Jensen-Seaman MI, Orlebeke K, Kwitek AE, Jacob HJ, Lazar J) Am J Physiol Cell Physiol 2006 Dec;291(6):C1183-92 PMID: 16855218
  • Nomenclature of the rat Cyp genes and the problems of gene nomenclature in general [Nelson, D.R. (2005), 'Gene nomenclature by default, or BLASTing to Babel', Hum. Genomics Vol. 2, pp. 196-201]. (Levan G, Jacob HJ) Hum Genomics 2006 Jun;2(6):343; author reply 343-4 PMID: 16848971 PMCID: PMC3525163
  • Absence of an interaction between the Rf-1 and Rf-5 QTLs influencing susceptibility to renal damage in rats. (van Dijk SJ, Specht PA, Lazar J, Jacob HJ, Provoost AP) Nephron Exp Nephrol 2006;104(3):e96-e102 PMID: 16837819
  • Consomic strategies to localize genomic regions related to vascular reactivity in the Dahl salt-sensitive rat. (Kunert MP, Drenjancevic-Peric I, Dwinell MR, Lombard JH, Cowley AW Jr, Greene AS, Kwitek AE, Jacob HJ) Physiol Genomics 2006 Aug 16;26(3):218-25 PMID: 16772359
  • Synergistic QTL interactions between Rf-1 and Rf-3 increase renal damage susceptibility in double congenic rats. (Van Dijk SJ, Specht PA, Lazar J, Jacob HJ, Provoost AP) Kidney Int 2006 Apr;69(8):1369-76 PMID: 16541022
  • BN phenome: detailed characterization of the cardiovascular, renal, and pulmonary systems of the sequenced rat. (Kwitek AE, Jacob HJ, Baker JE, Dwinell MR, Forster HV, Greene AS, Kunert MP, Lombard JH, Mattson DL, Pritchard KA Jr, Roman RJ, Tonellato PJ, Cowley AW Jr) Physiol Genomics 2006 Apr 13;25(2):303-13 PMID: 16478827
  • Physiogenomic resources for rat models of heart, lung and blood disorders. (Malek RL, Wang HY, Kwitek AE, Greene AS, Bhagabati N, Borchardt G, Cahill L, Currier T, Frank B, Fu X, Hasinoff M, Howe E, Letwin N, Luu TV, Saeed A, Sajadi H, Salzberg SL, Sultana R, Thiagarajan M, Tsai J, Veratti K, White J, Quackenbush J, Jacob HJ, Lee NH) Nat Genet 2006 Feb;38(2):234-9 PMID: 16415889
  • Characterization of blood pressure and renal function in chromosome 5 congenic strains of Dahl S rats. (Roman RJ, Hoagland KM, Lopez B, Kwitek AE, Garrett MR, Rapp JP, Lazar J, Jacob HJ, Sarkis A) Am J Physiol Renal Physiol 2006 Jun;290(6):F1463-71 PMID: 16396943
  • Impact of genomics on research in the rat. (Lazar J, Moreno C, Jacob HJ, Kwitek AE) Genome Res 2005 Dec;15(12):1717-28 PMID: 16339370
  • Interaction between Rf-1 and Rf-4 quantitative trait loci increases susceptibility to renal damage in double congenic rats. (Van Dijk SJ, Specht PA, Lutz MM, Lazar J, Jacob HJ, Provoost AP) Kidney Int 2005 Dec;68(6):2462-72 PMID: 16316323
  • Identification of a QTL on chromosome 1 for impaired autoregulation of RBF in fawn-hooded hypertensive rats. (López B, Ryan RP, Moreno C, Sarkis A, Lazar J, Provoost AP, Jacob HJ, Roman RJ) Am J Physiol Renal Physiol 2006 May;290(5):F1213-21 PMID: 16303858
  • Fine mapping of Lvm1: a quantitative trait locus controlling heart size independently of blood pressure. (Di Nicolantonio R, Kostka V, Kwitek A, Jacob H, Thomas WG, Harrap SB) Pulm Pharmacol Ther 2006;19(1):70-3 PMID: 16286240
  • Tools and strategies for physiological genomics: the Rat Genome Database. (Twigger SN, Pasko D, Nie J, Shimoyama M, Bromberg S, Campbell D, Chen J, dela Cruz N, Fan C, Foote C, Harris G, Hickmann B, Ji Y, Jin W, Li D, Mathis J, Nenasheva N, Nigam R, Petri V, Reilly D, Ruotti V, Schauberger E, Seiler K, Slyper R, Smith J, Wang W, Wu W, Zhao L, Zuniga-Meyer A, Tonellato PJ, Kwitek AE, Jacob HJ) Physiol Genomics 2005 Oct 17;23(2):246-56 PMID: 16106031
  • Genome-wide scanning with SSLPs in the rat. (Moreno C, Kennedy K, Andrae JW, Jacob HJ) Methods Mol Med 2005;108:131-8 PMID: 16028680
  • Renal damage susceptibility and autoregulation in RF-1 and RF-5 congenic rats. (Van Dijk SJ, Specht PA, Lazar J, Jacob HJ, Provoost AP) Nephron Exp Nephrol 2005;101(2):e59-66 PMID: 15976509
  • Increased resistance to myocardial ischemia in the Brown Norway vs. Dahl S rat: role of nitric oxide synthase and Hsp90. (Shi Y, Hutchins W, Ogawa H, Chang CC, Pritchard KA Jr, Zhang C, Khampang P, Lazar J, Jacob HJ, Rafiee P, Baker JE) J Mol Cell Cardiol 2005 Apr;38(4):625-35 PMID: 15808839
  • RF-2 gene modulates proteinuria and albuminuria independently of changes in glomerular permeability in the fawn-hooded hypertensive rat. (Rangel-Filho A, Sharma M, Datta YH, Moreno C, Roman RJ, Iwamoto Y, Provoost AP, Lazar J, Jacob HJ) J Am Soc Nephrol 2005 Apr;16(4):852-6 PMID: 15758045
  • Distinct heritable patterns of angiographic coronary artery disease in families with myocardial infarction. (Fischer M, Broeckel U, Holmer S, Baessler A, Hengstenberg C, Mayer B, Erdmann J, Klein G, Riegger G, Jacob HJ, Schunkert H) Circulation 2005 Feb 22;111(7):855-62 PMID: 15710764
  • Genetic determinants on rat chromosome 6 modulate variation in the hypercapnic ventilatory response using consomic strains. (Dwinell MR, Forster HV, Petersen J, Rider A, Kunert MP, Cowley AW Jr, Jacob HJ) J Appl Physiol (1985) 2005 May;98(5):1630-8 PMID: 15661838
  • Substitution of chromosome 1 ameliorates L-NAME hypertension and renal disease in the fawn-hooded hypertensive rat. (Mattson DL, Kunert MP, Roman RJ, Jacob HJ, Cowley AW Jr) Am J Physiol Renal Physiol 2005 May;288(5):F1015-22 PMID: 15644486
  • Genetic linkage and association of the growth hormone secretagogue receptor (ghrelin receptor) gene in human obesity. (Baessler A, Hasinoff MJ, Fischer M, Reinhard W, Sonnenberg GE, Olivier M, Erdmann J, Schunkert H, Doering A, Jacob HJ, Comuzzie AG, Kissebah AH, Kwitek AE) Diabetes 2005 Jan;54(1):259-67 PMID: 15616037 PMCID: PMC2793077
  • The Rat Genome Database (RGD): developments towards a phenome database. (de la Cruz N, Bromberg S, Pasko D, Shimoyama M, Twigger S, Chen J, Chen CF, Fan C, Foote C, Gopinath GR, Harris G, Hughes A, Ji Y, Jin W, Li D, Mathis J, Nenasheva N, Nie J, Nigam R, Petri V, Reilly D, Wang W, Wu W, Zuniga-Meyer A, Zhao L, Kwitek A, Tonellato P, Jacob H) Nucleic Acids Res 2005 Jan 1;33(Database issue):D485-91 PMID: 15608243 PMCID: PMC540004
  • The Collaborative Cross, a community resource for the genetic analysis of complex traits. (Churchill GA, Airey DC, Allayee H, Angel JM, Attie AD, Beatty J, Beavis WD, Belknap JK, Bennett B, Berrettini W, Bleich A, Bogue M, Broman KW, Buck KJ, Buckler E, Burmeister M, Chesler EJ, Cheverud JM, Clapcote S, Cook MN, Cox RD, Crabbe JC, Crusio WE, Darvasi A, Deschepper CF, Doerge RW, Farber CR, Forejt J, Gaile D, Garlow SJ, Geiger H, Gershenfeld H, Gordon T, Gu J, Gu W, de Haan G, Hayes NL, Heller C, Himmelbauer H, Hitzemann R, Hunter K, Hsu HC, Iraqi FA, Ivandic B, Jacob HJ, Jansen RC, Jepsen KJ, Johnson DK, Johnson TE, Kempermann G, Kendziorski C, Kotb M, Kooy RF, Llamas B, Lammert F, Lassalle JM, Lowenstein PR, Lu L, Lusis A, Manly KF, Marcucio R, Matthews D, Medrano JF, Miller DR, Mittleman G, Mock BA, Mogil JS, Montagutelli X, Morahan G, Morris DG, Mott R, Nadeau JH, Nagase H, Nowakowski RS, O'Hara BF, Osadchuk AV, Page GP, Paigen B, Paigen K, Palmer AA, Pan HJ, Peltonen-Palotie L, Peirce J, Pomp D, Pravenec M, Prows DR, Qi Z, Reeves RH, Roder J, Rosen GD, Schadt EE, Schalkwyk LC, Seltzer Z, Shimomura K, Shou S, Sillanpää MJ, Siracusa LD, Snoeck HW, Spearow JL, Svenson K, Tarantino LM, Threadgill D, Toth LA, Valdar W, de Villena FP, Warden C, Whatley S, Williams RW, Wiltshire T, Yi N, Zhang D, Zhang M, Zou F, Complex Trait Consortium) Nat Genet 2004 Nov;36(11):1133-7 PMID: 15514660
  • Mapping the genetic determinants of hypertension, metabolic diseases, and related phenotypes in the lyon hypertensive rat. (Bilusic M, Bataillard A, Tschannen MR, Gao L, Barreto NE, Vincent M, Wang T, Jacob HJ, Sassard J, Kwitek AE) Hypertension 2004 Nov;44(5):695-701 PMID: 15452030
  • Transgenic rescue demonstrates involvement of the Ian5 gene in T cell development in the rat. (Michalkiewicz M, Michalkiewicz T, Ettinger RA, Rutledge EA, Fuller JM, Moralejo DH, Van Yserloo B, MacMurray AJ, Kwitek AE, Jacob HJ, Lander ES, Lernmark A) Physiol Genomics 2004 Oct 4;19(2):228-32 PMID: 15328390
  • Consomic rat model systems for physiological genomics. (Cowley AW Jr, Liang M, Roman RJ, Greene AS, Jacob HJ) Acta Physiol Scand 2004 Aug;181(4):585-92 PMID: 15283774
  • High-density rat radiation hybrid maps containing over 24,000 SSLPs, genes, and ESTs provide a direct link to the rat genome sequence. (Kwitek AE, Gullings-Handley J, Yu J, Carlos DC, Orlebeke K, Nie J, Eckert J, Lemke A, Andrae JW, Bromberg S, Pasko D, Chen D, Scheetz TE, Casavant TL, Soares MB, Sheffield VC, Tonellato PJ, Jacob HJ) Genome Res 2004 Apr;14(4):750-7 PMID: 15060019 PMCID: PMC383322
  • Identification of candidate disease genes by EST alignments, synteny, and expression and verification of Ensembl genes on rat chromosome 1q43-54. (Vitt U, Gietzen D, Stevens K, Wingrove J, Becha S, Bulloch S, Burrill J, Chawla N, Chien J, Crawford M, Ison C, Kearney L, Kwong M, Park J, Policky J, Weiler M, White R, Xu Y, Daniels S, Jacob H, Jensen-Seaman MI, Lazar J, Stuve L, Schmidt J) Genome Res 2004 Apr;14(4):640-50 PMID: 15060005 PMCID: PMC383308
  • Comparative recombination rates in the rat, mouse, and human genomes. (Jensen-Seaman MI, Furey TS, Payseur BA, Lu Y, Roskin KM, Chen CF, Thomas MA, Haussler D, Jacob HJ) Genome Res 2004 Apr;14(4):528-38 PMID: 15059993 PMCID: PMC383296
  • Integrative genomics: in silico coupling of rat physiology and complex traits with mouse and human data. (Twigger SN, Nie J, Ruotti V, Yu J, Chen D, Li D, Mathis J, Narayanasamy V, Gopinath GR, Pasko D, Shimoyama M, De La Cruz N, Bromberg S, Kwitek AE, Jacob HJ, Tonellato PJ) Genome Res 2004 Apr;14(4):651-60 PMID: 15060006 PMCID: PMC383309
  • Genome sequence of the Brown Norway rat yields insights into mammalian evolution. (Gibbs RA, Weinstock GM, Metzker ML, Muzny DM, Sodergren EJ, Scherer S, Scott G, Steffen D, Worley KC, Burch PE, Okwuonu G, Hines S, Lewis L, DeRamo C, Delgado O, Dugan-Rocha S, Miner G, Morgan M, Hawes A, Gill R, Celera, Holt RA, Adams MD, Amanatides PG, Baden-Tillson H, Barnstead M, Chin S, Evans CA, Ferriera S, Fosler C, Glodek A, Gu Z, Jennings D, Kraft CL, Nguyen T, Pfannkoch CM, Sitter C, Sutton GG, Venter JC, Woodage T, Smith D, Lee HM, Gustafson E, Cahill P, Kana A, Doucette-Stamm L, Weinstock K, Fechtel K, Weiss RB, Dunn DM, Green ED, Blakesley RW, Bouffard GG, De Jong PJ, Osoegawa K, Zhu B, Marra M, Schein J, Bosdet I, Fjell C, Jones S, Krzywinski M, Mathewson C, Siddiqui A, Wye N, McPherson J, Zhao S, Fraser CM, Shetty J, Shatsman S, Geer K, Chen Y, Abramzon S, Nierman WC, Havlak PH, Chen R, Durbin KJ, Egan A, Ren Y, Song XZ, Li B, Liu Y, Qin X, Cawley S, Worley KC, Cooney AJ, D'Souza LM, Martin K, Wu JQ, Gonzalez-Garay ML, Jackson AR, Kalafus KJ, McLeod MP, Milosavljevic A, Virk D, Volkov A, Wheeler DA, Zhang Z, Bailey JA, Eichler EE, Tuzun E, Birney E, Mongin E, Ureta-Vidal A, Woodwark C, Zdobnov E, Bork P, Suyama M, Torrents D, Alexandersson M, Trask BJ, Young JM, Huang H, Wang H, Xing H, Daniels S, Gietzen D, Schmidt J, Stevens K, Vitt U, Wingrove J, Camara F, Mar Albà M, Abril JF, Guigo R, Smit A, Dubchak I, Rubin EM, Couronne O, Poliakov A, Hübner N, Ganten D, Goesele C, Hummel O, Kreitler T, Lee YA, Monti J, Schulz H, Zimdahl H, Himmelbauer H, Lehrach H, Jacob HJ, Bromberg S, Gullings-Handley J, Jensen-Seaman MI, Kwitek AE, Lazar J, Pasko D, Tonellato PJ, Twigger S, Ponting CP, Duarte JM, Rice S, Goodstadt L, Beatson SA, Emes RD, Winter EE, Webber C, Brandt P, Nyakatura G, Adetobi M, Chiaromonte F, Elnitski L, Eswara P, Hardison RC, Hou M, Kolbe D, Makova K, Miller W, Nekrutenko A, Riemer C, Schwartz S, Taylor J, Yang S, Zhang Y, Lindpaintner K, Andrews TD, Caccamo M, Clamp M, Clarke L, Curwen V, Durbin R, Eyras E, Searle SM, Cooper GM, Batzoglou S, Brudno M, Sidow A, Stone EA, Venter JC, Payseur BA, Bourque G, López-Otín C, Puente XS, Chakrabarti K, Chatterji S, Dewey C, Pachter L, Bray N, Yap VB, Caspi A, Tesler G, Pevzner PA, Haussler D, Roskin KM, Baertsch R, Clawson H, Furey TS, Hinrichs AS, Karolchik D, Kent WJ, Rosenbloom KR, Trumbower H, Weirauch M, Cooper DN, Stenson PD, Ma B, Brent M, Arumugam M, Shteynberg D, Copley RR, Taylor MS, Riethman H, Mudunuri U, Peterson J, Guyer M, Felsenfeld A, Old S, Mockrin S, Collins F, Rat Genome Sequencing Project Consortium) Nature 2004 Apr 1;428(6982):493-521 PMID: 15057822
  • Initial characterization of a rat model of diabetic nephropathy. (Nobrega MA, Fleming S, Roman RJ, Shiozawa M, Schlick N, Lazar J, Jacob HJ) Diabetes 2004 Mar;53(3):735-42 PMID: 14988259
  • Expression of G-protein alpha subunit genes in the vestibular periphery of Rattus norvegicus and their chromosomal mapping. (Cioffi JA, Erbe CB, Raphael R, Kwitek AE, Tiwari UK, Jacob HJ, Popper P, Wackym PA) Acta Otolaryngol 2003 Dec;123(9):1027-34 PMID: 14710903
  • Rat model of familial combined hyperlipidemia as a result of comparative mapping. (Ueno T, Tremblay J, Kunes J, Zicha J, Dobesova Z, Pausova Z, Deng AY, Sun YL, Jacob HJ, Hamet P) Physiol Genomics 2004 Mar 12;17(1):38-47 PMID: 14709677
  • Application of chromosomal substitution techniques in gene-function discovery. (Cowley AW Jr, Roman RJ, Jacob HJ) J Physiol 2004 Jan 1;554(Pt 1):46-55 PMID: 14678490 PMCID: PMC1664739
  • Gender-specific genetic determinants of blood pressure and organ weight: pharmacogenetic approach. (Ueno T, Tremblay J, Kunes J, Zicha J, Dobesová Z, Pausova Z, Deng AY, Sun Y, Jacob HJ, Hamet P) Physiol Res 2003;52(6):689-700 PMID: 14640890
  • Genetic dissection of lymphopenia from autoimmunity by introgression of mutated Ian5 gene onto the F344 rat. (Moralejo DH, Park HA, Speros SJ, MacMurray AJ, Kwitek AE, Jacob HJ, Lander ES, Lernmark A) J Autoimmun 2003 Dec;21(4):315-24 PMID: 14624755
  • Influence of diet and genetics on hypertension and renal disease in Dahl salt-sensitive rats. (Mattson DL, Kunert MP, Kaldunski ML, Greene AS, Roman RJ, Jacob HJ, Cowley AW Jr) Physiol Genomics 2004 Jan 15;16(2):194-203 PMID: 14600213
  • Genomic map of cardiovascular phenotypes of hypertension in female Dahl S rats. (Moreno C, Dumas P, Kaldunski ML, Tonellato PJ, Greene AS, Roman RJ, Cheng Q, Wang Z, Jacob HJ, Cowley AW Jr) Physiol Genomics 2003 Nov 11;15(3):243-57 PMID: 14532335
  • Consomic rats for the identification of genes and pathways underlying cardiovascular disease. (Roman RJ, Cowley AW Jr, Greene A, Kwitek AE, Tonellato PJ, Jacob HJ) Cold Spring Harb Symp Quant Biol 2002;67:309-15 PMID: 12858554
  • Genetic mapping and characterization of the bleeding disorder in the fawn-hooded hypertensive rat. (Datta YH, Wu FC, Dumas PC, Rangel-Filho A, Datta MW, Ning G, Cooley BC, Majewski RR, Provoost AP, Jacob HJ) Thromb Haemost 2003 Jun;89(6):1031-42 PMID: 12783116
  • Use of a three-color cDNA microarray platform to measure and control support-bound probe for improved data quality and reproducibility. (Hessner MJ, Wang X, Khan S, Meyer L, Schlicht M, Tackes J, Datta MW, Jacob HJ, Ghosh S) Nucleic Acids Res 2003 Jun 1;31(11):e60 PMID: 12771224 PMCID: PMC156737
  • Spatial and temporal pattern of Wnt-6 expression during chick development. (Rodríguez-Niedenführ M, Dathe V, Jacob HJ, Pröls F, Christ B) Anat Embryol (Berl) 2003 May;206(6):447-51 PMID: 12695910
  • Resolving the composite trait of hypertension into its pharmacogenetic determinants by acute pharmacological modulation of blood pressure regulatory systems. (Ueno T, Tremblay J, Kunes J, Zicha J, Dobesova Z, Pausova Z, Deng AY, Sun YL, Jacob HJ, Hamet P) J Mol Med (Berl) 2003 Jan;81(1):51-60 PMID: 12545249
  • Radiation hybrid mapping of five muscarinic acetylcholine receptor subtype genes in Rattus norvegicus. (Tseng J, Erbe CB, Kwitek AE, Jacob HJ, Popper P, Wackym PA) Hear Res 2002 Dec;174(1-2):86-92 PMID: 12433399
  • Identification of hypertension-related QTLs in African American sib pairs. (Kotchen TA, Broeckel U, Grim CE, Hamet P, Jacob H, Kaldunski ML, Kotchen JM, Schork NJ, Tonellato PJ, Cowley AW Jr) Hypertension 2002 Nov;40(5):634-9 PMID: 12411455
  • Lymphopenia in the BB rat model of type 1 diabetes is due to a mutation in a novel immune-associated nucleotide (Ian)-related gene. (MacMurray AJ, Moralejo DH, Kwitek AE, Rutledge EA, Van Yserloo B, Gohlke P, Speros SJ, Snyder B, Schaefer J, Bieg S, Jiang J, Ettinger RA, Fuller J, Daniels TL, Pettersson A, Orlebeke K, Birren B, Jacob HJ, Lander ES, Lernmark A) Genome Res 2002 Jul;12(7):1029-39 PMID: 12097339 PMCID: PMC186618
  • Mapping baroreceptor function to genome: a mathematical modeling approach. (Kendziorski CM, Cowley AW Jr, Greene AS, Salgado HC, Jacob HJ, Tonellato PJ) Genetics 2002 Apr;160(4):1687-95 PMID: 11973321 PMCID: PMC1462065
  • Transfer of the Rf-1 region from FHH onto the ACI background increases susceptibility to renal impairment. (Provoost AP, Shiozawa M, Van Dokkum RP, Jacob HJ) Physiol Genomics 2002 Feb 28;8(2):123-9 PMID: 11875190
  • Renal medullary genes in salt-sensitive hypertension: a chromosomal substitution and cDNA microarray study. (Liang M, Yuan B, Rute E, Greene AS, Zou AP, Soares P, MCQuestion GD, Slocum GR, Jacob HJ, Cowley AW Jr) Physiol Genomics 2002 Feb 28;8(2):139-49 PMID: 11875192
  • Rat genetics: attaching physiology and pharmacology to the genome. (Jacob HJ, Kwitek AE) Nat Rev Genet 2002 Jan;3(1):33-42 PMID: 11823789
  • A comprehensive linkage analysis for myocardial infarction and its related risk factors. (Broeckel U, Hengstenberg C, Mayer B, Holmer S, Martin LJ, Comuzzie AG, Blangero J, Nürnberg P, Reis A, Riegger GA, Jacob HJ, Schunkert H) Nat Genet 2002 Feb;30(2):210-4 PMID: 11818963
  • Multi-center genetic study of hypertension: The Family Blood Pressure Program (FBPP). (FBPP Investigators) Hypertension 2002 Jan;39(1):3-9 PMID: 11799070
  • Implications of circadian gene expression in kidney, liver and the effects of fasting on pharmacogenomic studies. (Kita Y, Shiozawa M, Jin W, Majewski RR, Besharse JC, Greene AS, Jacob HJ) Pharmacogenetics 2002 Jan;12(1):55-65 PMID: 11773865
  • Rat Genome Database (RGD): mapping disease onto the genome. (Twigger S, Lu J, Shimoyama M, Chen D, Pasko D, Long H, Ginster J, Chen CF, Nigam R, Kwitek A, Eppig J, Maltais L, Maglott D, Schuler G, Jacob H, Tonellato PJ) Nucleic Acids Res 2002 Jan 1;30(1):125-8 PMID: 11752273 PMCID: PMC99132
  • A genomic-systems biology map for cardiovascular function. (Stoll M, Cowley AW Jr, Tonellato PJ, Greene AS, Kaldunski ML, Roman RJ, Dumas P, Schork NJ, Wang Z, Jacob HJ) Science 2001 Nov 23;294(5547):1723-6 PMID: 11721057
  • Gene expression profiling leads to identification of GLI1-binding elements in target genes and a role for multiple downstream pathways in GLI1-induced cell transformation. (Yoon JW, Kita Y, Frank DJ, Majewski RR, Konicek BA, Nobrega MA, Jacob H, Walterhouse D, Iannaccone P) J Biol Chem 2002 Feb 15;277(7):5548-55 PMID: 11719506
  • Automated construction of high-density comparative maps between rat, human, and mouse. (Kwitek AE, Tonellato PJ, Chen D, Gullings-Handley J, Cheng YS, Twigger S, Scheetz TE, Casavant TL, Stoll M, Nobrega MA, Shiozawa M, Soares MB, Sheffield VC, Jacob HJ) Genome Res 2001 Nov;11(11):1935-43 PMID: 11691858 PMCID: PMC311144
  • The newly inbred cohen diabetic rat: a nonobese normolipidemic genetic model of diet-induced type 2 diabetes expressing sex differences. (Weksler-Zangen S, Yagil C, Zangen DH, Ornoy A, Jacob HJ, Yagil Y) Diabetes 2001 Nov;50(11):2521-9 PMID: 11679430
  • The genetic basis of plasma variation in adiponectin, a global endophenotype for obesity and the metabolic syndrome. (Comuzzie AG, Funahashi T, Sonnenberg G, Martin LJ, Jacob HJ, Black AE, Maas D, Takahashi M, Kihara S, Tanaka S, Matsuzawa Y, Blangero J, Cohen D, Kissebah A) J Clin Endocrinol Metab 2001 Sep;86(9):4321-5 PMID: 11549668
  • Identification of two susceptibility loci for vascular fragility in the Brown Norway rat. (Harris EL, Stoll M, Jones GT, Granados MA, Porteous WK, Van Rij AM, Jacob HJ) Physiol Genomics 2001 Aug 28;6(3):183-9 PMID: 11526202
  • Radiation hybrid mapping of 11 alpha and beta nicotinic acetylcholine receptor genes in Rattus norvegicus. (Tseng J, Kwitek-Black AE, Erbe CB, Popper P, Jacob HJ, Wackym PA) Brain Res Mol Brain Res 2001 Jul 13;91(1-2):169-73 PMID: 11457506
  • Genetic rat models of hypertension: relationship to human hypertension. (Stoll M, Jacob HJ) Curr Hypertens Rep 2001 Apr;3(2):157-64 PMID: 11276399
  • Sequence interpretation. Functional annotation of mouse genome sequences. (Nadeau JH, Balling R, Barsh G, Beier D, Brown SD, Bucan M, Camper S, Carlson G, Copeland N, Eppig J, Fletcher C, Frankel WN, Ganten D, Goldowitz D, Goodnow C, Guenet JL, Hicks G, Hrabe de Angelis M, Jackson I, Jacob HJ, Jenkins N, Johnson D, Justice M, Kay S, Kingsley D, Lehrach H, Magnuson T, Meisler M, Poustka A, Rinchik EM, Rossant J, Russell LB, Schimenti J, Shiroishi T, Skarnes WC, Soriano P, Stanford W, Takahashi JS, Wurst W, Zimmer A, International Mouse Mutagenesis Consortium) Science 2001 Feb 16;291(5507):1251-5 PMID: 11233449
  • Brown Norway chromosome 13 confers protection from high salt to consomic Dahl S rat. (Cowley AW Jr, Roman RJ, Kaldunski ML, Dumas P, Dickhout JG, Greene AS, Jacob HJ) Hypertension 2001 Feb;37(2 Pt 2):456-61 PMID: 11230318
  • Generation of a high-density rat EST map. (Scheetz TE, Raymond MR, Nishimura DY, McClain A, Roberts C, Birkett C, Gardiner J, Zhang J, Butters N, Sun C, Kwitek-Black A, Jacob H, Casavant TL, Soares MB, Sheffield VC) Genome Res 2001 Mar;11(3):497-502 PMID: 11230173 PMCID: PMC311028
  • The use of designer rats in the genetic dissection of hypertension. (Kwitek-Black AE, Jacob HJ) Curr Hypertens Rep 2001 Feb;3(1):12-8 PMID: 11177702
  • Quantitative trait loci on chromosomes 3 and 17 influence phenotypes of the metabolic syndrome. (Kissebah AH, Sonnenberg GE, Myklebust J, Goldstein M, Broman K, James RG, Marks JA, Krakower GR, Jacob HJ, Weber J, Martin L, Blangero J, Comuzzie AG) Proc Natl Acad Sci U S A 2000 Dec 19;97(26):14478-83 PMID: 11121050 PMCID: PMC18944
  • Retinoic acid-induced tissue transglutaminase and apoptosis in vascular smooth muscle cells. (Ou H, Haendeler J, Aebly MR, Kelly LA, Cholewa BC, Koike G, Kwitek-Black A, Jacob HJ, Berk BC, Miano JM) Circ Res 2000 Nov 10;87(10):881-7 PMID: 11073883
  • High-throughput scanning of the rat genome using interspersed repetitive sequence-PCR markers. (Gösele C, Hong L, Kreitler T, Rossmann M, Hieke B, Gross U, Kramer M, Himmelbauer H, Bihoreau MT, Kwitek-Black AE, Twigger S, Tonellato PJ, Jacob HJ, Schalkwyk LC, Lindpaintner K, Ganten D, Lehrach H, Knoblauch M) Genomics 2000 Nov 1;69(3):287-94 PMID: 11056046
  • Evidence of gene-gene interactions in the genetic susceptibility to renal impairment after unilateral nephrectomy. (Shiozawa M, Provoost AP, van Dokkum RP, Majewski RR, Jacob HJ) J Am Soc Nephrol 2000 Nov;11(11):2068-78 PMID: 11053483
  • The future of genetic case-control studies. (Schork NJ, Fallin D, Thiel B, Xu X, Broeckel U, Jacob HJ, Cohen D) Adv Genet 2001;42:191-212 PMID: 11037322
  • Genetically defined risk of salt sensitivity in an intercross of Brown Norway and Dahl S rats. (Cowley AW Jr, Stoll M, Greene AS, Kaldunski ML, Roman RJ, Tonellato PJ, Schork NJ, Dumas P, Jacob HJ) Physiol Genomics 2000 Apr 27;2(3):107-15 PMID: 11015589
  • Localization of a small genomic region associated with elevated ACE. (Zhu X, McKenzie CA, Forrester T, Nickerson DA, Broeckel U, Schunkert H, Doering A, Jacob HJ, Cooper RS, Rieder MJ) Am J Hum Genet 2000 Nov;67(5):1144-53 PMID: 11001581 PMCID: PMC1288557
  • Blood pressure and the susceptibility to renal damage after unilateral nephrectomy and L-NAME-induced hypertension in rats. (van Dokkum RP, Jacob HJ, Provoost AP) Nephrol Dial Transplant 2000 Sep;15(9):1337-43 PMID: 10978388
  • Lack of association between a biallelic polymorphism in the adducin gene and blood pressure in whites and African Americans. (Schork NJ, Chakravarti A, Thiel B, Fornage M, Jacob HJ, Cai R, Rotimi CN, Cooper RS, Weder AB) Am J Hypertens 2000 Jun;13(6 Pt 1):693-8 PMID: 10912755
  • New target regions for human hypertension via comparative genomics. (Stoll M, Kwitek-Black AE, Cowley AW Jr, Harris EL, Harrap SB, Krieger JE, Printz MP, Provoost AP, Sassard J, Jacob HJ) Genome Res 2000 Apr;10(4):473-82 PMID: 10779487 PMCID: PMC310887
  • Spontaneous elastic tissue lesions in the rat abdominal aorta, a genetically determined phenotype. (Jones GT, Harris EL, Jacob HJ, van Rij AM) J Vasc Res 2000 Mar-Apr;37(2):73-81 PMID: 10754392
  • Resistance to myocardial ischemia in five rat strains: is there a genetic component of cardioprotection? (Baker JE, Konorev EA, Gross GJ, Chilian WM, Jacob HJ) Am J Physiol Heart Circ Physiol 2000 Apr;278(4):H1395-400 PMID: 10749737
  • Gene structure and chromosomal mapping of the rat smooth muscle calponin gene. (Nobrega MA, Shiozawa M, Koike G, Jacob HJ, Miano JM) Mamm Genome 2000 Feb;11(2):115-9 PMID: 10656925
  • Functional genomics and rat models. (Jacob HJ) Genome Res 1999 Nov;9(11):1013-6 PMID: 10568741
  • A rat genetic linkage map including 67 new microsatellite markers. (Fakhrai-Rad H, Jiao H, Li LS, Glaser A, Koike G, Jacob HJ, Luthman H, Galli J) Mamm Genome 1999 Nov;10(11):1102-5 PMID: 10556432
  • Molecular cloning, tissue-specific expression, and chromosomal localization of a novel nerve growth factor-regulated G-protein- coupled receptor, nrg-1. (Glickman M, Malek RL, Kwitek-Black AE, Jacob HJ, Lee NH) Mol Cell Neurosci 1999 Aug;14(2):141-52 PMID: 10532805
  • BB rat diabetes susceptibility and body weight regulation genes colocalize on chromosome 2. (Klaff LS, Koike G, Jiang J, Wang Y, Bieg S, Pettersson A, Lander E, Jacob H, Lernmark A) Mamm Genome 1999 Sep;10(9):883-7 PMID: 10441739
  • Physiological genetics: application to hypertension research. (Jacob HJ) Clin Exp Pharmacol Physiol 1999 Jul;26(7):530-5 PMID: 10405781
  • A high-density integrated genetic linkage and radiation hybrid map of the laboratory rat. (Steen RG, Kwitek-Black AE, Glenn C, Gullings-Handley J, Van Etten W, Atkinson OS, Appel D, Twigger S, Muir M, Mull T, Granados M, Kissebah M, Russo K, Crane R, Popp M, Peden M, Matise T, Brown DM, Lu J, Kingsmore S, Tonellato PJ, Rozen S, Slonim D, Young P, Jacob HJ) Genome Res 1999 Jun;9(6):AP1-8, insert PMID: 10400928
  • Zebrafish genetic map with 2000 microsatellite markers. (Shimoda N, Knapik EW, Ziniti J, Sim C, Yamada E, Kaplan S, Jackson D, de Sauvage F, Jacob H, Fishman MC) Genomics 1999 Jun 15;58(3):219-32 PMID: 10373319
  • Gene-based anchoring of the rat genetic linkage and cytogenetic maps. (Szpirer C, Szpirer J, Van Vooren P, Tissir F, Simon JS, Koike G, Jacob HJ, Lander ES, Helou K, Klinga-Levan K, Levan G) Transplant Proc 1999 May;31(3):1541-3 PMID: 10330994
  • Altered renal hemodynamics and impaired myogenic responses in the fawn-hooded rat. (van Dokkum RP, Sun CW, Provoost AP, Jacob HJ, Roman RJ) Am J Physiol 1999 Mar;276(3 Pt 2):R855-63 PMID: 10070148
  • Mapping and characterization of quantitative trait loci for non-insulin-dependent diabetes mellitus with an improved genetic map in the Otsuka Long-Evans Tokushima fatty rat. (Wei S, Wei K, Moralejo DH, Ogino T, Koike G, Jacob HJ, Sugiura K, Sasaki Y, Yamada T, Matsumoto K) Mamm Genome 1999 Mar;10(3):249-58 PMID: 10051320
  • Localization of rat genes in the nitric oxide signaling pathway: candidates for the pathogenesis of complex diseases. (Koike G, Chiche JD, Shiozawa M, Simon JS, Szpirer J, Jacob HJ, Szpirer C, Bloch KD) Mamm Genome 1999 Jan;10(1):71-3 PMID: 9892738
  • Impaired autoregulation of renal blood flow in the fawn-hooded rat. (Van Dokkum RP, Alonso-Galicia M, Provoost AP, Jacob HJ, Roman RJ) Am J Physiol 1999 Jan;276(1 Pt 2):R189-96 PMID: 9887194
  • Identification of quantitative trait loci for non-insulin-dependent diabetes mellitus that interact with body weight in the Otsuka Long-Evans Tokushima Fatty rat. (Moralejo DH, Wei S, Wei K, Weksler-Zangen S, Koike G, Jacob HJ, Hirashima T, Kawano K, Sugiura K, Sasaki Y, Ogino T, Yamada T, Matsumoto K) Proc Assoc Am Physicians 1998 Nov-Dec;110(6):545-58 PMID: 9824537
  • Gene-based anchoring of the rat genetic linkage and cytogenetic maps: new regional localizations, orientation of the linkage groups, and insights into mammalian chromosome evolution. (Szpirer C, Szpirer J, Van Vooren P, Tissir F, Simon JS, Koike G, Jacob HJ, Lander ES, Helou K, Klinga-Levan K, Levan G) Mamm Genome 1998 Sep;9(9):721-34 PMID: 9716657
  • An integrated genetic linkage map of the laboratory rat. (Brown DM, Matise TC, Koike G, Simon JS, Winer ES, Zangen S, McLaughlin MG, Shiozawa M, Atkinson OS, Hudson JR Jr, Chakravarti A, Lander ES, Jacob HJ) Mamm Genome 1998 Jul;9(7):521-30 PMID: 9657848
  • EbEST: an automated tool using expressed sequence tags to delineate gene structure. (Jiang J, Jacob HJ) Genome Res 1998 Mar;8(3):268-75 PMID: 9521930 PMCID: PMC310694
  • Genetic control of susceptibility for renal damage in hypertensive fawn-hooded rats. (Brown DM, Van Dokkum RP, Korte MR, McLauglin MG, Shiozawa M, Jacob HJ, Provoost AP) Ren Fail 1998 Mar;20(2):407-11 PMID: 9574469
  • Susceptibility genes for end-organ damage. New strategies to understand diabetic and hypertensive nephropathy. (Broeckel U, Shiozawa M, Kissebah AH, Provoost AP, Jacob HJ) Nephrol Dial Transplant 1998 Apr;13(4):840-2 PMID: 9568834
  • A microsatellite genetic linkage map for zebrafish (Danio rerio). (Knapik EW, Goodman A, Ekker M, Chevrette M, Delgado J, Neuhauss S, Shimoda N, Driever W, Fishman MC, Jacob HJ) Nat Genet 1998 Apr;18(4):338-43 PMID: 9537415
  • Genetic isolation of iddm 1 on chromosome 4 in the biobreeding (BB) rat. (Bieg S, Koike G, Jiang J, Klaff L, Pettersson A, MacMurray AJ, Jacob HJ, Lander ES, Lernmark A) Mamm Genome 1998 Apr;9(4):324-6 PMID: 9530633
  • Genetic differences define severity of renal damage after L-NAME-induced hypertension in rats. (Van Dokkum RP, Jacob HJ, Provoost AP) J Am Soc Nephrol 1998 Mar;9(3):363-71 PMID: 9513898
  • Independent genetic susceptibility to cardiac hypertrophy in inherited hypertension. (Innes BA, McLaughlin MG, Kapuscinski MK, Jacob HJ, Harrap SB) Hypertension 1998 Mar;31(3):741-6 PMID: 9495256
  • Mapping of the rat SM22 gene to chromosome 8q24: a candidate for high blood pressure and cardiac hypertrophy. (Koike G, Miano JM, Vanvooren P, Shiozawa M, Szpirer C, Jacob HJ) Mamm Genome 1998 Jan;9(1):76-7 PMID: 9434951
  • Difference in susceptibility of developing renal damage in normotensive fawn-hooded (FHL) and August x Copenhagen Irish (ACI) rats after N(omega)-nitro-L-arginine methyl ester induced hypertension. (van Dokkum RP, Jacob HJ, Provoost AP) Am J Hypertens 1997 Oct;10(10 Pt 1):1109-16 PMID: 9370381
  • A large pedigree with valvuloseptal defects. (Schunkert H, Bröckel U, Kromer EP, Elsner D, Jacob HJ, Riegger GA) Am J Cardiol 1997 Oct 1;80(7):968-70 PMID: 9382022
  • Strain-specific deletions in exon 10 of rat K-kininogen and T1-kininogen genes allow mapping of both genes to rat chromosome 11. (Harris EL, Grigor MR, Innes BA, Harrap SB, Koike G, Jacob HJ) Mamm Genome 1997 Oct;8(10):791-2 PMID: 9321484
  • Interval mapping and congenic strains for a blood pressure QTL on rat chromosome 13. (Zhang QY, Dene H, Deng AY, Garrett MR, Jacob HJ, Rapp JP) Mamm Genome 1997 Sep;8(9):636-41 PMID: 9271663
  • Localization of the rat genes encoding glucagon, glucagon receptor, and insulin receptor, candidates for diabetes mellitus susceptibility loci. (Szpirer C, Szpirer J, Vanvooren P, Rivière M, Maget B, Svoboda M, Shiozawa M, Simon JS, Jacob HJ, Koike G) Mamm Genome 1997 Aug;8(8):586-8 PMID: 9250867
  • Genetic determinants of pulmonary hypertension in fawn-hooded rats. (Stelzner T, Hofmann TA, Brown D, Deng A, Jacob HJ) Chest 1997 Jun;111(6 Suppl):96S PMID: 9184548
  • Transfer of a salt-resistant renin allele raises blood pressure in Dahl salt-sensitive rats. (Jiang J, Stec DE, Drummond H, Simon JS, Koike G, Jacob HJ, Roman RJ) Hypertension 1997 Feb;29(2):619-27 PMID: 9040448
  • Extensions to quantitative trait locus mapping in experimental organisms. (Schork NJ, Nath SP, Lindpaintner K, Jacob HJ) Hypertension 1996 Dec;28(6):1104-11 PMID: 8952606
  • A reference cross DNA panel for zebrafish (Danio rerio) anchored with simple sequence length polymorphisms. (Knapik EW, Goodman A, Atkinson OS, Roberts CT, Shiozawa M, Sim CU, Weksler-Zangen S, Trolliet MR, Futrell C, Innes BA, Koike G, McLaughlin MG, Pierre L, Simon JS, Vilallonga E, Roy M, Chiang PW, Fishman MC, Driever W, Jacob HJ) Development 1996 Dec;123:451-60 PMID: 9007262
  • Genetic mapping and chromosome localization of the rat mitochondrial glycerol-3-phosphate dehydrogenase gene, a candidate for non-insulin-dependent diabetes mellitus. (Koike G, Van Vooren P, Shiozawa M, Galli J, Li LS, Glaser A, Balasubramanyam A, Brown LJ, Luthman H, Szpirer C, MacDonald MJ, Jacob HJ) Genomics 1996 Nov 15;38(1):96-9 PMID: 8954787
  • Use of AFLP markers for gene mapping and QTL detection in the rat. (Otsen M, den Bieman M, Kuiper MT, Pravenec M, Kren V, Kurtz TW, Jacob HJ, Lankhorst A, van Zutphen BF) Genomics 1996 Nov 1;37(3):289-94 PMID: 8938440
  • Novel missense mutation in the cyclic nucleotide-binding domain of HERG causes long QT syndrome. (Satler CA, Walsh EP, Vesely MR, Plummer MH, Ginsburg GS, Jacob HJ) Am J Med Genet 1996 Oct 2;65(1):27-35 PMID: 8914737
  • Renal cytochrome P4504A activity and salt sensitivity in spontaneously hypertensive rats. (Stec DE, Trolliet MR, Krieger JE, Jacob HJ, Roman RJ) Hypertension 1996 Jun;27(6):1329-36 PMID: 8641744
  • Lack of association of trinucleotide repeat polymorphisms in very-low-density lipoprotein receptor gene with Alzheimer's disease. (Chung H, Roberts CT, Greenberg S, Rebeck GW, Christie R, Wallace R, Jacob HJ, Hyman BT) Ann Neurol 1996 Jun;39(6):800-3 PMID: 8651653
  • Chromosomal mapping of the rat Slc4a family of anion exchanger genes, Ae1, Ae2, and Ae3. (Simon JS, Deshmukh G, Couch FJ, Merajver SD, Weber BL, Van Vooren P, Tissil F, Szpirer J, Szpirer C, Alper SL, Jacob HJ, Brosius FC 3rd) Mamm Genome 1996 May;7(5):380-2 PMID: 8661729
  • A landmark for orphan genomes? (Jacob HJ) Nat Genet 1996 May;13(1):14-5 PMID: 8673094
  • Chronic inhalation of nitric oxide inhibits neointimal formation after balloon-induced arterial injury. (Lee JS, Adrie C, Jacob HJ, Roberts JD Jr, Zapol WM, Bloch KD) Circ Res 1996 Feb;78(2):337-42 PMID: 8575078
  • Effects of renin gene transfer on blood pressure and renin gene expression in a congenic strain of Dahl salt-resistant rats. (St Lezin EM, Pravenec M, Wong AL, Liu W, Wang N, Lu S, Jacob HJ, Roman RJ, Stec DE, Wang JM, Reid IA, Kurtz TW) J Clin Invest 1996 Jan 15;97(2):522-7 PMID: 8567976 PMCID: PMC507046
  • Mapping of the rat ribosomal protein S18 gene (Rps 18) to chromosome 20p12. (Larsson M, Tissir F, Walter L, Gunther E, Jacob H, Klinga-Levan K, Levan G) Mamm Genome 1996 Jan;7(1):90 PMID: 8903742
  • Renal disease susceptibility and hypertension are under independent genetic control in the fawn-hooded rat. (Brown DM, Provoost AP, Daly MJ, Lander ES, Jacob HJ) Nat Genet 1996 Jan;12(1):44-51 PMID: 8528250
  • Genetic analysis of non-insulin dependent diabetes mellitus in the GK rat. (Galli J, Li LS, Glaser A, Ostenson CG, Jiao H, Fakhrai-Rad H, Jacob HJ, Lander ES, Luthman H) Nat Genet 1996 Jan;12(1):31-7 PMID: 8528247
  • Spectral analysis of arterial pressure lability in rats with sinoaortic deafferentation. (Jacob HJ, Ramanthan A, Pan SG, Brody MJ, Myers GA) Am J Physiol 1995 Dec;269(6 Pt 2):R1481-8 PMID: 8594953
  • Cloning, characterization, and genetic mapping of the rat type 2 angiotensin II receptor gene. (Koike G, Winer ES, Horiuchi M, Brown DM, Szpirer C, Dzau VJ, Jacob HJ) Hypertension 1995 Dec;26(6 Pt 1):998-1002 PMID: 7490161
  • Investigation of the phenylethanolamine N-methyltransferase gene as a candidate gene for hypertension. (Koike G, Jacob HJ, Krieger JE, Szpirer C, Hoehe MR, Horiuchi M, Dzau VJ) Hypertension 1995 Oct;26(4):595-601 PMID: 7558218
  • Use of simple sequence length polymorphisms for genetic characterization of rat inbred strains. (Otsen M, Den Bieman M, Winer ES, Jacob HJ, Szpirer J, Szpirer C, Bender K, Van Zutphen LF) Mamm Genome 1995 Sep;6(9):595-601 PMID: 8535065
  • A biometrical genome search in rats reveals the multigenic basis of blood pressure variation. (Schork NJ, Krieger JE, Trolliet MR, Franchini KG, Koike G, Krieger EM, Lander ES, Dzau VJ, Jacob HJ) Genome Res 1995 Sep;5(2):164-72 PMID: 9132270
  • Predictability of heterozygosity scores and polymorphism information content values for rat genetic markers. (Pettersson A, Winer ES, Weksler-Zangen S, Lernmark A, Jacob HJ) Mamm Genome 1995 Aug;6(8):512-20 PMID: 8589519
  • Thyroiditis in the BB rat is associated with lymphopenia but occurs independently of diabetes. (Pettersson A, Wilson D, Daniels T, Tobin S, Jacob HJ, Lander ES, Lernmark A) J Autoimmun 1995 Aug;8(4):493-505 PMID: 7492346
  • Three members of the nitric oxide synthase II gene family (NOS2A, NOS2B, and NOS2C) colocalize to human chromosome 17. (Bloch KD, Wolfram JR, Brown DM, Roberts JD Jr, Zapol DG, Lepore JJ, Filippov G, Thomas JE, Jacob HJ, Bloch DB) Genomics 1995 Jun 10;27(3):526-30 PMID: 7558036
  • Cytosolic phospholipase A2 gene in human and rat: chromosomal localization and polymorphic markers. (Tay A, Simon JS, Squire J, Hamel K, Jacob HJ, Skorecki K) Genomics 1995 Mar 1;26(1):138-41 PMID: 7782073
  • Genetic map of rat chromosome 5 including the fatty (fa) locus. (Truett GE, Jacob HJ, Miller J, Drouin G, Bahary N, Smoller JW, Lander ES, Leibel RL) Mamm Genome 1995 Jan;6(1):25-30 PMID: 7719022
  • A genetic linkage map of the laboratory rat, Rattus norvegicus. (Jacob HJ, Brown DM, Bunker RK, Daly MJ, Dzau VJ, Goodman A, Koike G, Kren V, Kurtz T, Lernmark A) Nat Genet 1995 Jan;9(1):63-9 PMID: 7704027
  • Human type 2 angiotensin II receptor gene: cloned, mapped to the X chromosome, and its mRNA is expressed in the human lung. (Koike G, Horiuchi M, Yamada T, Szpirer C, Jacob HJ, Dzau VJ) Biochem Biophys Res Commun 1994 Sep 30;203(3):1842-50 PMID: 7945336
  • Genetic identification of Mcs-1, a rat mammary carcinoma suppressor gene. (Hsu LC, Kennan WS, Shepel LA, Jacob HJ, Szpirer C, Szpirer J, Lander ES, Gould MN) Cancer Res 1994 May 15;54(10):2765-70 PMID: 8168109
  • Angiotensin converting enzyme and genetic hypertension: cloning of rat cDNAs and characterization of the enzyme. (Koike G, Krieger JE, Jacob HJ, Mukoyama M, Pratt RE, Dzau VJ) Biochem Biophys Res Commun 1994 Jan 14;198(1):380-6 PMID: 8292044
  • Vascular injury induces angiotensinogen gene expression in the media and neointima. (Rakugi H, Jacob HJ, Krieger JE, Ingelfinger JR, Pratt RE) Circulation 1993 Jan;87(1):283-90 PMID: 8419017
  • Arterial pressure lability and renal sympathetic nerve activity are dissociated in SAD rats. (Barres C, Lewis SJ, Jacob HJ, Brody MJ) Am J Physiol 1992 Sep;263(3 Pt 2):R639-46 PMID: 1415652
  • Last update: 07/02/2014