Medical College of Wisconsin
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James A. Hokanson PhD

James A. Hokanson PhD profile photo picture

Assistant Professor

Institution: Medical College of Wisconsin
Department: Biomedical Engineering

View Curriculum Vitae

Research Areas of Interest

  • Autonomic Nervous System
  • Pelvic Floor Disorders
  • Signal Processing, Computer-Assisted
  • Urinary Bladder, Overactive

    • Publications (37)

  • The LURN urinary urgency and lifestyle wearable tracker (ULTra) study: Design and feasibility (Bradley CS, Hokanson JA, Francis SL, Bieber B, Laddu D, Amundsen CL, Bretschneider CE, Clemens JQ, Collins S, Kenton K, Lai HH, Andreev VP, Glaser AP, Helfand BT, Andrews C, Graff J, Kirkali Z, Kreder KJ) Continence September 2026;19 SCOPUS ID: 2-s2.0-105042581377 09/01/2026    
  • The LURN Study-What Have We "LURN"ed So Far? (Lai HH, LURN Study Group) Neurourol Urodyn 2026 Apr;45(4):654-661 PMID: 41944009 SCOPUS ID: 2-s2.0-105035036305 04/07/2026    
  • Lessons learned from conducting a multi-center lower urinary tract physiology study: the LURN experience. (Yang CC, Hokanson JA, Kirby AC, Gillespie BW, Lai HH, Kreder KJ, Bretschneider CE, Kirkali Z, Delancey JOL) Continence (Amst) 2026 Mar;17 PMID: 41877858 PMCID: PMC13007923 SCOPUS ID: 2-s2.0-105030963248 03/25/2026    
  • Lessons learned from conducting a multi-center lower urinary tract physiology study: the LURN experience (Yang CC, Hokanson JA, Kirby AC, Gillespie BW, Lai HH, Kreder KJ, Bretschneider CE, Kirkali Z, Delancey JOL) Continence March 2026;17 SCOPUS ID: 2-s2.0-105030963248 03/01/2026    
  • Lack of group-to-individual generalizability in people with lower urinary tract symptoms emphasizes the need for deep phenotyping and personalized treatments (Andreev VP, Smerdon C, Bieber B, Smith AR, Flynn K, Clemens JQ, Cella D, Yang CC, Kirkali Z, Weinfurt K, Amundsen C, Jelovsek JE, Hokanson J, Lentz A, Page D, Siddiqui N, Harshbarger T, Odom M, Gridley C, Foreman J, Morgan T, Guerrero M, Yu S, Sinha A, Bradley CS, Kreder K, Erickson BA, Fick D, Magnotta V, Polgreen P, Hollenbeck N, Bretschneider CE, Griffith JW, Kenton K, Helfand B, Geynisman-Tan J, Glaser A, Mueller M, Farina F, Fantus R, Boehm D, Marquez M, Antoniak M, Talaty P, John K, Shi J, Samsel T, DeLancey J, Fenner D, Harris R, Harte S, Cameron AP, Sarma A, Ippolito G, Gupta P, Horner W, Thompson J, Schmidt P, Mowatt G, Richardson S, Mathai S, Mubeenah S, Kirby A, Levendovszky SR, Gutta S, Vicars B, Covert H, Lai HH, Shimony J, Li F, Hayden P, Klim A, Graff J, Gillespie B, Durkin J, Sexton M, Nashif J, Goodrich N, Andrews C, Lu T, Remski C, Mullins C) Journal of Clinical and Translational Science 1 August 2025;9(1) SCOPUS ID: 2-s2.0-105012773239 08/01/2025    
  • Symptoms of Lower Urinary Tract Dysfunction Research Network (LURN II) Urinary Urgency Phenotyping Study: Methods and Baseline Urinary Symptoms by Age and Sex. (Ippolito GM, Kenton K, Bradley CS, Lu T, Bieber B, Clemens JQ, Kirby AC, Kirkali Z, Guerrero M, Yang CC, Kreder K, Emi Bretschneider C, Graff J, Nashif J, Griffith JW, Henry Lai H, Amundsen CL, Cameron AP, LURN Study Group) Neurourol Urodyn 2025 Jun;44(5):1007-1021 PMID: 40275438 PMCID: PMC12164244 SCOPUS ID: 2-s2.0-105004363907 04/25/2025       6 Citations
  • Sexual function in women with bothersome lower urinary tract symptoms: findings from the symptoms of lower urinary tract dysfunction research network (LURN) cohort study. (Bretschneider CE, Smerdon C, Bieber B, Goodrich N, Griffith J, Lai HH, Hokanson JA, Kirby AC, Smith A, Guerrero M, Gutta S, Flynn KE, John K, Bradley CS, LURN Study Group) J Sex Med 2025 Jun 03;22(6):1035-1042 PMID: 40269441 SCOPUS ID: 2-s2.0-105008306977 04/24/2025       3 Citations
  • Expanded Physiological Testing of the Lower Urinary Tract in Asymptomatic Women and Those With Urgency Urinary Incontinence: Findings From the LURN-Organ Study. (Hokanson JA, DeLancey JOL, Kirby AC, Gillespie B, Lai HH, Kreder KJ, Bretschneider CE, Slavik N, Andrews C, Andreev V, Black L, Richardson S, Kenton K, Kirkali Z, Yang CC, Symptoms of Lower Urinary Tract Dysfunction Research Network (LURN) Study Group) Neurourol Urodyn 2025 Jun;44(5):987-996 PMID: 40159923 PMCID: PMC12414437 SCOPUS ID: 2-s2.0-105002006334 03/31/2025       2 Citations
  • Faster bladder filling in rats reduces detrusor overactivity but worsens (i.e., decreases) bladder compliance. (He W, Slavik N, Braun J, Samadifam F, Hokanson JA) Am J Physiol Renal Physiol 2024 Dec 01;327(6):F985-F993 PMID: 39417826 SCOPUS ID: 2-s2.0-85210548741 10/17/2024       1 Citation
  • Predicting success using response after lead implantation with sacral neuromodulation for urgency incontinence. (Hendrickson WK, Zhang C, Hokanson JA, Nygaard IE, Presson AP) Neurourol Urodyn 2024 Nov;43(8):1776-1783 PMID: 39075815 PMCID: PMC11495989 SCOPUS ID: 2-s2.0-85199993375 07/30/2024       1 Citation
  • Developing a urinary incontinence primary care pathway: a mixed methods study. (Luebke MC, Neuner JM, Balza J, Davidson ERW, Hokanson JA, Marowski S, Corey O'Connor R, Schmitt E, Winn AN, Flynn KE) Fam Pract 2024 Oct 08;41(5):798-806 PMID: 39026426 PMCID: PMC11461143 SCOPUS ID: 2-s2.0-85206018320 07/19/2024       3 Citations
  • Structural Changes in Brain White Matter Tracts Associated With Overactive Bladder Revealed by Diffusion Tensor Magnetic Resonance Imaging: Findings From a Symptoms of Lower Urinary Tract Dysfunction Research Network Cross-Sectional Case-Control Study. (Lai HH, Rutlin J, Smith AR, Helmuth ME, Hokanson JA, Yang CC, Clemens JQ, Magnotta VA, Bretschneider CE, Kenton K, DeLancey JOL, John K, Kirkali Z, Shimony JS) J Urol 2024 Aug;212(2):351-361 PMID: 38717915 PMCID: PMC11233244 SCOPUS ID: 2-s2.0-85198675736 05/08/2024       12 Citations
  • National Urogynecology Research Agenda: A Path Forward for Advancing the Treatment and Management of Pelvic Floor Disorders (Dunivan GC, Ackenbom MF, Alperin M, Anger JT, Antosh DD, Bharucha AE, Birder LA, Boyd SS, Bradley MS, Brehman EH, Brito LGO, Brown HW, Brown O, Burnett LA, Caldwell LE, Carter-Brooks CM, Chermanksy CJ, Cichowski SB, Connell KA, Delancey JOL, Damaser MS, De Nisco NJ, Dubinskaya A, Glass DH, Guess MK, Hale DS, Hannan JL, High RA, Hokanson JA, Jacobs KM, Kelley RS, Kisby CK, Kravitz E, Lowder JL, Markland AD, Meister MRL, Meyer I, Moalli PA, Mysorekar IU, Parker-Autry CY, Richter HE, Rogers RG, Rolston R, Rubin RS, Sheyn D, Shinnick JK, Siddiqui NY, Suyama JA, Uloko MI, Walter JE, Welch EK, Wolfe AJ, Zeno A, McDermott CD) Urogynecology 1 November 2023;29(11):851-855 SCOPUS ID: 2-s2.0-85178045630 11/01/2023       5 Citations
  • Pathways and parameters of sacral neuromodulation in rats. (Hokanson JA, Langdale CL, Grill WM) Am J Physiol Renal Physiol 2023 Dec 01;325(6):F757-F769 PMID: 37795537 PMCID: PMC10874681 SCOPUS ID: 2-s2.0-85178541433 10/05/2023       9 Citations
  • Reply to: The case against urethral failure is not a critical factor in female urinary incontinence. Now what? The integral theory system. (DeLancey JO, Hokanson JA) Neurourol Urodyn 2022 Nov;41(8):1934-1937 PMID: 36047393 PMCID: PMC9633378 SCOPUS ID: 2-s2.0-85137216690 09/02/2022       1 Citation
  • Urethral failure is a critical factor in female urinary incontinence. Now what? (Hokanson JA, DeLancey JOL) Neurourol Urodyn 2022 Feb;41(2):532-538 PMID: 35032361 PMCID: PMC8892071 SCOPUS ID: 2-s2.0-85122733353 01/16/2022       9 Citations
  • Predicting outcomes after intradetrusor onabotulinumtoxina for non-neurogenic urgency incontinence in women. (Hendrickson WK, Xie G, Rahn DD, Amundsen CL, Hokanson JA, Bradley M, Smith AL, Sung VW, Visco AG, Luo S, Jelovsek JE) Neurourol Urodyn 2022 Jan;41(1):432-447 PMID: 34859485 PMCID: PMC9014828 SCOPUS ID: 2-s2.0-85120416004 12/04/2021       12 Citations
  • Machine Learning for Urodynamic Detection of Detrusor Overactivity. (Hobbs KT, Choe N, Aksenov LI, Reyes L, Aquino W, Routh JC, Hokanson JA) Urology 2022 Jan;159:247-254 PMID: 34757048 PMCID: PMC8865755 SCOPUS ID: 2-s2.0-85119898046 11/11/2021       51 Citations
  • Advancing our understanding of the neural control of the female human urethra. (Yang CC, Hokanson JA, Keast JR) Neurourol Urodyn 2022 Jan;41(1):35-41 PMID: 34605569 PMCID: PMC8738110 SCOPUS ID: 2-s2.0-85116447054 10/05/2021       2 Citations
  • Noncancerous Genitourinary Conditions as a Public Health Priority: Conceptualizing the Hidden Burden. (Brady SS, Bavendam TG, Bradway CK, Conroy B, Dowling-Castronovo A, Epperson CN, Hijaz AK, Hsi RS, Huss K, Kim M, Lazar J, Lee RK, Liu CK, Loizou CN, Miran S, Mody L, Norton JM, Reynolds WS, Sutcliffe S, Zhang N, Hokanson JA) Urology 2022 Aug;166:39-49 PMID: 34536410 PMCID: PMC8924010 SCOPUS ID: 2-s2.0-85117361969 09/19/2021       15 Citations
  • State-dependent bioelectronic interface to control bladder function. (Hokanson JA, Langdale CL, Sridhar A, Milliken P, Grill WM) Sci Rep 2021 Jan 11;11(1):314 PMID: 33431964 PMCID: PMC7801663 SCOPUS ID: 2-s2.0-85099250413 01/13/2021       19 Citations
  • Effects of intravesical prostaglandin E2 on bladder function are preserved in capsaicin-desensitized rats. (Hokanson JA, Langdale CL, Milliken PH, Sridhar A, Grill WM) Am J Physiol Renal Physiol 2021 Feb 01;320(2):F212-F223 PMID: 33283648 PMCID: PMC7948121 SCOPUS ID: 2-s2.0-85102091039 12/08/2020       5 Citations
  • Stimulation of the pelvic nerve increases bladder capacity in the PGE2 cat model of overactive bladder. (Langdale CL, Hokanson JA, Milliken PH, Sridhar A, Grill WM) Am J Physiol Renal Physiol 2020 Jun 01;318(6):F1357-F1368 PMID: 32308021 PMCID: PMC7717121 SCOPUS ID: 2-s2.0-85084695863 04/21/2020       9 Citations
  • An open-source platform for analyzing and sharing worm-behavior data. (Javer A, Currie M, Lee CW, Hokanson J, Li K, Martineau CN, Yemini E, Grundy LJ, Li C, Ch'ng Q, Schafer WR, Nollen EAA, Kerr R, Brown AEX) Nat Methods 2018 Sep;15(9):645-646 PMID: 30171234 PMCID: PMC6284784 SCOPUS ID: 2-s2.0-85052684893 09/02/2018       93 Citations
  • Effects of Synchronous Electrode Pulses on Neural Recruitment During Multichannel Microstimulation. (Hokanson JA, Gaunt RA, Weber DJ) Sci Rep 2018 Aug 30;8(1):13067 PMID: 30166583 PMCID: PMC6117337 SCOPUS ID: 2-s2.0-85052705333 09/01/2018       10 Citations
  • Detection of Bladder Contractions From the Activity of the External Urethral Sphincter in Rats Using Sparse Regression. (Rutter EM, Langdale CL, Hokanson JA, Hamilton F, Tran H, Grill WM, Flores KB) IEEE Trans Neural Syst Rehabil Eng 2018 Aug;26(8):1636-1644 PMID: 30004881 PMCID: PMC6531051 SCOPUS ID: 2-s2.0-85049801947 07/14/2018       6 Citations
  • Stimulation of the sensory pudendal nerve increases bladder capacity in the rat. (Hokanson JA, Langdale CL, Sridhar A, Grill WM) Am J Physiol Renal Physiol 2018 Apr 01;314(4):F543-F550 PMID: 29141938 PMCID: PMC5966759 SCOPUS ID: 2-s2.0-85038850979 11/17/2017       30 Citations
  • Real-time decoding of bladder pressure from pelvic nerve activity CP (Lubba C, Mitrani E, Hokanson J, Grill WM, Schultz SR) International IEEE EMBS Conference on Neural Engineering Ner 10 August 2017:617-620 SCOPUS ID: 2-s2.0-85028599007 08/10/2017       4 Citations
  • OAB without an overactive bladder in the acute prostaglandin E2 rat model. (Hokanson JA, Langdale CL, Sridhar A, Grill WM) Am J Physiol Renal Physiol 2017 Nov 01;313(5):F1169-F1177 PMID: 28768666 PMCID: PMC5792156 SCOPUS ID: 2-s2.0-85036501656 08/05/2017       19 Citations
  • Stimulation of the pelvic nerve increases bladder capacity in the prostaglandin E2 rat model of overactive bladder. (Langdale CL, Hokanson JA, Sridhar A, Grill WM) Am J Physiol Renal Physiol 2017 Sep 01;313(3):F657-F665 PMID: 28615244 PMCID: PMC5625104 SCOPUS ID: 2-s2.0-85028935121 06/16/2017       21 Citations
  • Neuroprosthetic control of lower urinary tract function (Hokanson JA, Amundsen CL, Grill WM) Neuroprosthetics Theory and Practice Second Edition 10 March 2017:537-565 SCOPUS ID: 2-s2.0-85059502627 03/10/2017    
  • Neuroprostheses for somatosensory function (Fisher LE, Hokanson JA, Weber DJ) Implantable Neuroprostheses for Restoring Function March 04, 2015:127-151 SCOPUS ID: 2-s2.0-84940106101 03/04/2015       2 Citations
  • OpenWorm: An open-science approach to modeling Caenorhabditis elegans (Szigeti B, Gleeson P, Vella M, Khayrulin S, Palyanov A, Hokanson J, Currie M, Cantarelli M, Idili G, Larson S) Frontiers in Computational Neuroscience 3 November 2014;8(November):1-7 SCOPUS ID: 2-s2.0-84908658401 11/03/2014       99 Citations
  • Effects of spatial and temporal parameters of primary afferent microstimulation on neural responses evoked in primary somatosensory cortex of an anesthetized cat. (Hokanson JA, Ayers CA, Gaunt RA, Bruns TM, Weber DJ) Annu Int Conf IEEE Eng Med Biol Soc 2011;2011:7533-6 PMID: 22256081 PMCID: PMC3475719 SCOPUS ID: 2-s2.0-84861656375 01/19/2012       8 Citations
  • Limb-state information encoded by peripheral and central somatosensory neurons: implications for an afferent interface. (Weber DJ, London BM, Hokanson JA, Ayers CA, Gaunt RA, Torres RR, Zaaimi B, Miller LE) IEEE Trans Neural Syst Rehabil Eng 2011 Oct;19(5):501-13 PMID: 21878419 PMCID: PMC3694199 SCOPUS ID: 2-s2.0-80054087420 09/01/2011       84 Citations
  • A computational model for estimating recruitment of primary afferent fibers by intraneural stimulation in the dorsal root ganglia. (Bourbeau DJ, Hokanson JA, Rubin JE, Weber DJ) J Neural Eng 2011 Oct;8(5):056009 PMID: 21844639 PMCID: PMC3178662 SCOPUS ID: 2-s2.0-80053178263 08/17/2011       18 Citations
  • Microstimulation of primary afferent neurons in the L7 dorsal root ganglia using multielectrode arrays in anesthetized cats: thresholds and recruitment properties. (Gaunt RA, Hokanson JA, Weber DJ) J Neural Eng 2009 Oct;6(5):055009 PMID: 19721181 PMCID: PMC2894985 SCOPUS ID: 2-s2.0-70449709041 09/02/2009       49 Citations
    • Last update: 08/27/2026