Medical College of Wisconsin
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James Kincaid PhD

Department Chair and Professor, Biophysical Chemistry

Institution: Marquette University
Department: Chemistry

Member of the Cancer Center


Publications

  • Spectral Characterization of a Novel NO Sensing Protein in Bacteria: NosP. (Bacon BA, Liu Y, Kincaid JR, Boon EM) Biochemistry 2018 Oct 30;57(43):6187-6200 PMID: 30272959 PMCID: PMC6217815 10/03/2018    
  • Human Cytochrome CYP17A1: The Structural Basis for Compromised Lyase Activity with 17-Hydroxyprogesterone. (Mak PJ, Duggal R, Denisov IG, Gregory MC, Sligar SG, Kincaid JR) J Am Chem Soc 2018 06 13;140(23):7324-7331 PMID: 29758981 PMCID: PMC5999583 05/16/2018       3 Citations
  • Human P450 CYP17A1: Control of Substrate Preference by Asparagine 202. (Gregory MC, Mak PJ, Khatri Y, Kincaid JR, Sligar SG) Biochemistry 2018 02 06;57(5):764-771 PMID: 29283561 PMCID: PMC5801141 12/29/2017       1 Citations
  • Active Site Structures of CYP11A1 in the Presence of Its Physiological Substrates and Alterations upon Binding of Adrenodoxin. (Zhu Q, Mak PJ, Tuckey RC, Kincaid JR) Biochemistry 2017 10 31;56(43):5786-5797 PMID: 28991453 10/11/2017       2 Citations
  • Analysis of Heme Iron Coordination in DGCR8: The Heme-Binding Component of the Microprocessor Complex. (Girvan HM, Bradley JM, Cheesman MR, Kincaid JR, Liu Y, Czarnecki K, Fisher K, Leys D, Rigby SE, Munro AW) Biochemistry 2016 09 13;55(36):5073-83 PMID: 27546061 08/23/2016       3 Citations
  • Evidence that cytochrome b5 acts as a redox donor in CYP17A1 mediated androgen synthesis. (Duggal R, Liu Y, Gregory MC, Denisov IG, Kincaid JR, Sligar SG) Biochem Biophys Res Commun 2016 08 19;477(2):202-8 PMID: 27297105 PMCID: PMC4935565 06/15/2016       13 Citations
  • The use of isomeric testosterone dimers to explore allosteric effects in substrate binding to cytochrome P450 CYP3A4. (Denisov IG, Mak PJ, Grinkova YV, Bastien D, Bérubé G, Sligar SG, Kincaid JR) J Inorg Biochem 2016 05;158:77-85 PMID: 26774838 PMCID: PMC4887402 01/18/2016       13 Citations
  • Unveiling the crucial intermediates in androgen production. (Mak PJ, Gregory MC, Denisov IG, Sligar SG, Kincaid JR) Proc Natl Acad Sci U S A 2015 Dec 29;112(52):15856-61 PMID: 26668369 PMCID: PMC4703009 12/17/2015       27 Citations
  • Resonance Raman spectroscopy reveals pH-dependent active site structural changes of lactoperoxidase compound 0 and its ferryl heme O-O bond cleavage products. (Mak PJ, Thammawichai W, Wiedenhoeft D, Kincaid JR) J Am Chem Soc 2015 Jan 14;137(1):349-61 PMID: 25506715 12/17/2014       15 Citations
  • Resonance Raman spectroscopy of the oxygenated intermediates of human CYP19A1 implicates a compound i intermediate in the final lyase step. (Mak PJ, Luthra A, Sligar SG, Kincaid JR) J Am Chem Soc 2014 Apr 02;136(13):4825-8 PMID: 24645879 PMCID: PMC3985783 03/22/2014       28 Citations
  • Using resonance Raman cross-section data to estimate the spin state populations of Cytochromes P450. (Mak PJ, Zhu Q, Kincaid JR) J Raman Spectrosc 2013 Dec 01;44(12):1792-1794 PMID: 24443630 PMCID: PMC3891783 01/21/2014    
  • Resonance Raman spectroscopy reveals that substrate structure selectively impacts the heme-bound diatomic ligands of CYP17. (Mak PJ, Gregory MC, Sligar SG, Kincaid JR) Biochemistry 2014 Jan 14;53(1):90-100 PMID: 24328388 PMCID: PMC3922198 12/18/2013       13 Citations
  • Experimental documentation of the structural consequences of hydrogen-bonding interactions to the proximal cysteine of a cytochrome P450. (Mak PJ, Yang Y, Im S, Waskell LA, Kincaid JR) Angew Chem Int Ed Engl 2012 Oct 08;51(41):10403-7 PMID: 22968976 PMCID: PMC3517159 09/13/2012       15 Citations
  • Defining CYP3A4 structural responses to substrate binding. Raman spectroscopic studies of a nanodisc-incorporated mammalian cytochrome P450. (Mak PJ, Denisov IG, Grinkova YV, Sligar SG, Kincaid JR) J Am Chem Soc 2011 Feb 09;133(5):1357-66 PMID: 21207936 PMCID: PMC3033474 01/07/2011       28 Citations
  • Defining the structural consequences of mechanism-based inactivation of mammalian cytochrome P450 2B4 using resonance Raman spectroscopy. (Mak PJ, Zhang H, Hollenberg PF, Kincaid JR) J Am Chem Soc 2010 Feb 10;132(5):1494-5 PMID: 20078059 PMCID: PMC2820406 01/19/2010       11 Citations
  • Resonance Raman interrogation of the consequences of heme rotational disorder in myoglobin and its ligated derivatives. (Rwere F, Mak PJ, Kincaid JR) Biochemistry 2008 Dec 02;47(48):12869-77 PMID: 18986170 PMCID: PMC2654223 11/07/2008       8 Citations
  • Resonance Raman spectroscopic studies of hydroperoxo derivatives of cobalt-substituted myoglobin. (Mak PJ, Kincaid JR) J Inorg Biochem 2008 Oct;102(10):1952-7 PMID: 18723225 PMCID: PMC2605091 08/30/2008       14 Citations
  • Defining resonance Raman spectral responses to substrate binding by cytochrome P450 from Pseudomonas putida. (Mak PJ, Kaluka D, Manyumwa ME, Zhang H, Deng T, Kincaid JR) Biopolymers 2008 Nov;89(11):1045-53 PMID: 18655143 PMCID: PMC2556855 07/26/2008       17 Citations
  • Resonance Raman studies of cytochrome P450 2B4 in its interactions with substrates and redox partners. (Mak PJ, Im SC, Zhang H, Waskell LA, Kincaid JR) Biochemistry 2008 Mar 25;47(12):3950-63 PMID: 18311926 03/04/2008       17 Citations
  • The impact of altered protein-heme interactions on the resonance Raman spectra of heme proteins. Studies of heme rotational disorder. (Rwere F, Mak PJ, Kincaid JR) Biopolymers 2008 Mar;89(3):179-86 PMID: 18008322 11/17/2007       10 Citations
  • Resonance Raman detection of the hydroperoxo intermediate in the cytochrome P450 enzymatic cycle. (Mak PJ, Denisov IG, Victoria D, Makris TM, Deng T, Sligar SG, Kincaid JR) J Am Chem Soc 2007 May 23;129(20):6382-3 PMID: 17461587 PMCID: PMC2574425 04/28/2007       41 Citations
  • Low frequency resonance Raman spectra of isolated alpha and beta subunits of hemoglobin and their deuterated analogues. (Podstawka E, Mak PJ, Kincaid JR, Proniewicz LM) Biopolymers 2006 Dec 05;83(5):455-66 PMID: 16845667 07/18/2006       16 Citations
  • Effects of systematic peripheral group deuteration on the low-frequency resonance Raman spectra of myoglobin derivatives. (Mak PJ, Podstawka E, Kincaid JR, Proniewicz LM) Biopolymers 2004 Oct 15;75(3):217-28 PMID: 15378481 09/21/2004       21 Citations
  • Resonance Raman spectroscopic studies of hydroperoxo-myoglobin at cryogenic temperatures. (Ibrahim M, Denisov IG, Makris TM, Kincaid JR, Sligar SG) J Am Chem Soc 2003 Nov 12;125(45):13714-8 PMID: 14599210 11/06/2003       43 Citations
  • Resonance Raman evidence for protein-induced out-of-plane distortion of the heme prosthetic group of mammalian lactoperoxidase. (Zbylut SD, Kincaid JR) J Am Chem Soc 2002 Jun 12;124(23):6751-8 PMID: 12047196 06/06/2002       18 Citations
  • Synthesis and Spectroscopic Characterization of a Zeolite-Entrapped Ru(bpy)(2)(dpp)(2+) Complex. (Bhuiyan AA, Kincaid JR) Inorg Chem 1999 Oct 18;38(21):4759-4764 PMID: 11671202 10/24/2001    
  • Synthesis and Spectroscopic Characterization of Zinc Tetra(3,4-pyridine)Porphyrazine Entrapped within the Supercages of Y-Zeolite. (Szulbinski WS, Kincaid JR) Inorg Chem 1998 Sep 21;37(19):5014-5020 PMID: 11670671 10/24/2001    
  • Zeolite-based organized molecular assemblies. photophysical characterization and documentation of donor oxidation upon photosensitized charge separation. (Bhuiyan AA, Kincaid JR) Inorg Chem 2001 Aug 13;40(17):4464-71 PMID: 11487356 08/07/2001       13 Citations
  • Hydrogen-bonding interactions in the active sites of cytochrome P450cam and its site-directed mutants. (Deng T, Macdonald ID, Simianu MC, Sykora M, Kincaid JR, Sligar SG) J Am Chem Soc 2001 Jan 17;123(2):269-78 PMID: 11456513 07/18/2001       42 Citations
  • Zeolite-entrapped organized molecular assemblies. New evidence for highly efficient adjacent cage dyad formation and constrained rotational mobility of tris-ligated polypyridine complexes. (Szulbinski WS, Ma'nuel DJ, Kincaid JR) Inorg Chem 2001 Jul 02;40(14):3443-7 PMID: 11421690 06/26/2001       9 Citations
  • Resonance raman studies of heme structural differences in subunits of deoxy hemoglobin. (Podstawka E, Rajani C, Kincaid JR, Proniewicz LM) Biopolymers 2000;57(4):201-7 PMID: 10861384 06/22/2000       20 Citations
  • The development of zeolite-entrapped organized molecular assemblies. (Kincaid JR) Chemistry 2000 Nov 17;6(22):4055-61 PMID: 11128272 01/11/2000       35 Citations
  • Resonance Raman spectra of native and mesoheme-reconstituted horseradish peroxidase and their catalytic intermediates. (Kincaid JR, Zheng Y, Al-Mustafa J, Czarnecki K) J Biol Chem 1996 Nov 15;271(46):28805-11 PMID: 8910524 11/15/1996       40 Citations
  • Resonance Raman investigation of cyanide ligated beef liver and Aspergillus niger catalases. (al-Mustafa J, Sykora M, Kincaid JR) J Biol Chem 1995 May 05;270(18):10449-60 PMID: 7737979 05/05/1995       19 Citations
  • Structure and dynamics of transient species using time-resolved resonance Raman spectroscopy. (Kincaid JR) Methods Enzymol 1995;246:460-501 PMID: 7752934 01/01/1995       13 Citations
  • Low frequency vibrational modes of oxygenated myoglobin, hemoglobins, and modified derivatives. (Jeyarajah S, Proniewicz LM, Bronder H, Kincaid JR) J Biol Chem 1994 Dec 09;269(49):31047-50 PMID: 7983043 12/09/1994       36 Citations
  • Resonance Raman study of cyanide-ligated horseradish peroxidase. Detection of two binding geometries and direct evidence for the "push-pull" effect. (al-Mustafa J, Kincaid JR) Biochemistry 1994 Mar 01;33(8):2191-7 PMID: 8117676 03/01/1994       40 Citations
  • Distinct heme active-site structure in lactoperoxidase revealed by resonance Raman spectroscopy. (Hu S, Treat RW, Kincaid JR) Biochemistry 1993 Sep 28;32(38):10125-30 PMID: 8399138 09/28/1993       39 Citations
  • Heme active-site structural characterization of chloroperoxidase by resonance Raman spectroscopy. (Hu S, Kincaid JR) J Biol Chem 1993 Mar 25;268(9):6189-93 PMID: 8384203 03/25/1993       37 Citations
  • Resonance Raman studies of the carbonmonoxy form of catalase. Evidence for and effects of phenolate ligation. (Hu S, Kincaid JR) FEBS Lett 1992 Dec 21;314(3):293-6 PMID: 1468561 12/21/1992       20 Citations
  • Resonance Raman studies of hemoglobins reconstituted with mesoheme. Unperturbed iron-histidine stretching frequencies in a functionally altered hemoglobin. (Jeyarajah S, Kincaid JR) Biochemistry 1990 May 29;29(21):5087-94 PMID: 2378867 05/29/1990       16 Citations
  • Last update: 11/26/2018
    jenkins-FCD Prod-300 626508253d14e4184314fb9f66322a03a5906796