Medical College of Wisconsin
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James M. Cook PhD

James M. Cook PhD profile photo picture

University Distinguished Professor

Institution: University of Wisconsin - Milwaukee
Department: Chemistry and Biochemistry

Publications (61)

  • Different Benzodiazepines Bind with Distinct Binding Modes to GABAA Receptors. (Elgarf AA, Siebert DCB, Steudle F, Draxler A, Li G, Huang S, Cook JM, Ernst M, Scholze P) ACS Chem Biol 2018 Aug 17;13(8):2033-2039 PMID: 29767950 PMCID: PMC6102643 SCOPUS ID: 2-s2.0-85047377557 05/17/2018       23 Citations
  • Evidence That Sedative Effects of Benzodiazepines Involve Unexpected GABAA Receptor Subtypes: Quantitative Observation Studies in Rhesus Monkeys. (Duke AN, Meng Z, Platt DM, Atack JR, Dawson GR, Reynolds DS, Tiruveedhula VVNPB, Li G, Stephen MR, Sieghart W, Cook JM, Rowlett JK) J Pharmacol Exp Ther 2018 Jul;366(1):145-157 PMID: 29720564 PMCID: PMC5988000 SCOPUS ID: 2-s2.0-85054826868 05/04/2018       17 Citations
  • An antidepressant-related pharmacological signature for positive allosteric modulators of α2/3-containing GABAA receptors. (Methuku KR, Li X, Cerne R, Gleason SD, Schkeryantz JM, Tiruveedhula VVNPB, Golani LK, Li G, Poe MM, Rahman MT, Cook JM, Fisher JL, Witkin JM) Pharmacol Biochem Behav 2018 Jul;170:9-13 PMID: 29715490 SCOPUS ID: 2-s2.0-85046636547 05/02/2018       14 Citations
  • A Novel Orally Available Asthma Drug Candidate That Reduces Smooth Muscle Constriction and Inflammation by Targeting GABAA Receptors in the Lung. (Forkuo GS, Nieman AN, Kodali R, Zahn NM, Li G, Rashid Roni MS, Stephen MR, Harris TW, Jahan R, Guthrie ML, Yu OB, Fisher JL, Yocum GT, Emala CW, Steeber DA, Stafford DC, Cook JM, Arnold LA) Mol Pharm 2018 May 07;15(5):1766-1777 PMID: 29578347 PMCID: PMC5954213 SCOPUS ID: 2-s2.0-85046694256 03/27/2018       29 Citations
  • Design and Synthesis of Novel Deuterated Ligands Functionally Selective for the γ-Aminobutyric Acid Type A Receptor (GABAAR) α6 Subtype with Improved Metabolic Stability and Enhanced Bioavailability. (Knutson DE, Kodali R, Divović B, Treven M, Stephen MR, Zahn NM, Dobričić V, Huber AT, Meirelles MA, Verma RS, Wimmer L, Witzigmann C, Arnold LA, Chiou LC, Ernst M, Mihovilovic MD, Savić MM, Sieghart W, Cook JM) J Med Chem 2018 Mar 22;61(6):2422-2446 PMID: 29481759 PMCID: PMC6941172 SCOPUS ID: 2-s2.0-85044203204 02/27/2018       33 Citations
  • Negative allosteric modulation of alpha 5-containing GABAA receptors engenders antidepressant-like effects and selectively prevents age-associated hyperactivity in tau-depositing mice. (Xu NZ, Ernst M, Treven M, Cerne R, Wakulchik M, Li X, Jones TM, Gleason SD, Morrow D, Schkeryantz JM, Rahman MT, Li G, Poe MM, Cook JM, Witkin JM) Psychopharmacology (Berl) 2018 Apr;235(4):1151-1161 PMID: 29374303 SCOPUS ID: 2-s2.0-85041000322 01/28/2018       19 Citations
  • Total Synthesis of Sarpagine-Related Bioactive Indole Alkaloids. (Rahman MT, Deschamps JR, Imler GH, Cook JM) Chemistry 2018 Feb 16;24(10):2354-2359 PMID: 29244896 SCOPUS ID: 2-s2.0-85040792303 12/16/2017       23 Citations
  • Identification of Staphylococcus aureus Cellular Pathways Affected by the Stilbenoid Lead Drug SK-03-92 Using a Microarray. (Schwan WR, Polanowski R, Dunman PM, Medina-Bielski S, Lane M, Rott M, Lipker L, Wescott A, Monte A, Cook JM, Baumann DD, Tiruveedhula VVNPB, Witzigmann CM, Mikel C, Rahman MT) Antibiotics (Basel) 2017 Sep 11;6(3) PMID: 28892020 PMCID: PMC5617981 SCOPUS ID: 2-s2.0-85030979782 09/12/2017       4 Citations
  • Concise Total Synthesis of (-)-Affinisine Oxindole, (+)-Isoalstonisine, (+)-Alstofoline, (-)-Macrogentine, (+)-Na -Demethylalstonisine, (-)-Alstonoxine A, and (+)-Alstonisine. (Stephen MR, Rahman MT, Tiruveedhula VVNPB, Fonseca GO, Deschamps JR, Cook JM) Chemistry 2017 Nov 07;23(62):15805-15819 PMID: 28875520 PMCID: PMC6168078 SCOPUS ID: 2-s2.0-85031661673 09/07/2017       19 Citations
  • Neurobiological correlates of state-dependent context fear. (Meyer MAA, Corcoran KA, Chen HJ, Gallego S, Li G, Tiruveedhula VV, Cook JM, Radulovic J) Learn Mem 2017 Sep;24(9):385-391 PMID: 28814463 PMCID: PMC5580530 SCOPUS ID: 2-s2.0-85027586238 08/18/2017       13 Citations
  • Positive modulation of α5 GABAA receptors in preadolescence prevents reduced locomotor response to amphetamine in adult female but not male rats prenatally exposed to lipopolysaccharide. (Batinić B, Santrač A, Jančić I, Li G, Vidojević A, Marković B, Cook JM, Savić MM) Int J Dev Neurosci 2017 Oct;61:31-39 PMID: 28610974 PMCID: PMC5563212 SCOPUS ID: 2-s2.0-85020699441 06/15/2017       14 Citations
  • Further evaluation of the potential anxiolytic activity of imidazo[1,5-a][1,4]diazepin agents selective for α2/3-containing GABAA receptors. (Witkin JM, Cerne R, Wakulchik M, S J, Gleason SD, Jones TM, Li G, Arnold LA, Li JX, Schkeryantz JM, Methuku KR, Cook JM, Poe MM) Pharmacol Biochem Behav 2017 Jun;157:35-40 PMID: 28442369 PMCID: PMC5519285 SCOPUS ID: 2-s2.0-85019841584 04/27/2017       22 Citations
  • Alleviation of Multiple Asthmatic Pathologic Features with Orally Available and Subtype Selective GABAA Receptor Modulators. (Forkuo GS, Nieman AN, Yuan NY, Kodali R, Yu OB, Zahn NM, Jahan R, Li G, Stephen MR, Guthrie ML, Poe MM, Hartzler BD, Harris TW, Yocum GT, Emala CW, Steeber DA, Stafford DC, Cook JM, Arnold LA) Mol Pharm 2017 Jun 05;14(6):2088-2098 PMID: 28440659 PMCID: PMC5497587 SCOPUS ID: 2-s2.0-85020166818 04/26/2017       25 Citations
  • Abuse-related effects of subtype-selective GABAA receptor positive allosteric modulators in an assay of intracranial self-stimulation in rats. (Schwienteck KL, Li G, Poe MM, Cook JM, Banks ML, Stevens Negus S) Psychopharmacology (Berl) 2017 Jul;234(14):2091-2101 PMID: 28365836 PMCID: PMC5875719 SCOPUS ID: 2-s2.0-85016514074 04/04/2017       13 Citations
  • Identification of a novel, fast-acting GABAergic antidepressant. (McMurray KMJ, Ramaker MJ, Barkley-Levenson AM, Sidhu PS, Elkin PK, Reddy MK, Guthrie ML, Cook JM, Rawal VH, Arnold LA, Dulawa SC, Palmer AA) Mol Psychiatry 2018 Feb;23(2):384-391 PMID: 28322281 PMCID: PMC5608625 SCOPUS ID: 2-s2.0-85015625674 03/23/2017       30 Citations
  • Pharmacological and antihyperalgesic properties of the novel α2/3 preferring GABAA receptor ligand MP-III-024. (Fischer BD, Schlitt RJ, Hamade BZ, Rehman S, Ernst M, Poe MM, Li G, Kodali R, Arnold LA, Cook JM) Brain Res Bull 2017 May;131:62-69 PMID: 28267561 PMCID: PMC5501353 SCOPUS ID: 2-s2.0-85016137378 03/08/2017       22 Citations
  • Antinociceptive Effects of a Novel α2/α3-Subtype Selective GABAA Receptor Positive Allosteric Modulator. (Lewter LA, Fisher JL, Siemian JN, Methuku KR, Poe MM, Cook JM, Li JX) ACS Chem Neurosci 2017 Jun 21;8(6):1305-1312 PMID: 28150939 PMCID: PMC5686453 SCOPUS ID: 2-s2.0-85019846739 02/06/2017       34 Citations
  • Neonatal bladder inflammation induces long-term visceral pain and altered responses of spinal neurons in adult rats. (Kannampalli P, Babygirija R, Zhang J, Poe MM, Li G, Cook JM, Shaker R, Banerjee B, Sengupta JN) Neuroscience 2017 Mar 27;346:349-364 PMID: 28126369 PMCID: PMC5337157 SCOPUS ID: 2-s2.0-85012926870 01/28/2017       17 Citations
  • Synthesis and Characterization of a Novel γ-Aminobutyric Acid Type A (GABAA) Receptor Ligand That Combines Outstanding Metabolic Stability, Pharmacokinetics, and Anxiolytic Efficacy. (Poe MM, Methuku KR, Li G, Verma AR, Teske KA, Stafford DC, Arnold LA, Cramer JW, Jones TM, Cerne R, Krambis MJ, Witkin JM, Jambrina E, Rehman S, Ernst M, Cook JM, Schkeryantz JM) J Med Chem 2016 Dec 08;59(23):10800-10806 PMID: 27933953 PMCID: PMC5215686 SCOPUS ID: 2-s2.0-85003442743 12/10/2016       40 Citations
  • Sex-Dependent Anti-Stress Effect of an α5 Subunit Containing GABAA Receptor Positive Allosteric Modulator. (Piantadosi SC, French BJ, Poe MM, Timić T, Marković BD, Pabba M, Seney ML, Oh H, Orser BA, Savić MM, Cook JM, Sibille E) Front Pharmacol 2016;7:446 PMID: 27920723 PMCID: PMC5118774 SCOPUS ID: 2-s2.0-85003691586 12/07/2016       47 Citations
  • Optimization of substituted imidazobenzodiazepines as novel asthma treatments. (Jahan R, Stephen MR, Forkuo GS, Kodali R, Guthrie ML, Nieman AN, Yuan NY, Zahn NM, Poe MM, Li G, Yu OB, Yocum GT, Emala CW, Stafford DC, Cook JM, Arnold LA) Eur J Med Chem 2017 Jan 27;126:550-560 PMID: 27915170 PMCID: PMC5253108 SCOPUS ID: 2-s2.0-85000671290 12/05/2016       17 Citations
  • Effects of the benzodiazepine GABAA α1-preferring antagonist 3-isopropoxy-β-carboline hydrochloride (3-ISOPBC) on alcohol seeking and self-administration in baboons. (Holtyn AF, Tiruveedhula VV, Stephen MR, Cook JM, Weerts EM) Drug Alcohol Depend 2017 Jan 01;170:25-31 PMID: 27865151 PMCID: PMC5183547 SCOPUS ID: 2-s2.0-84995700083 11/20/2016       9 Citations
  • Synthesis of Bisindole Alkaloids from the Apocynaceae Which Contain a Macroline or Sarpagine Unit: A Review. (Rahman MT, Tiruveedhula VV, Cook JM) Molecules 2016 Nov 14;21(11) PMID: 27854259 PMCID: PMC5214337 SCOPUS ID: 2-s2.0-84997638270 11/18/2016       42 Citations
  • Ester to amide substitution improves selectivity, efficacy and kinetic behavior of a benzodiazepine positive modulator of GABAA receptors containing the α5 subunit. (Stamenić TT, Poe MM, Rehman S, Santrač A, Divović B, Scholze P, Ernst M, Cook JM, Savić MM) Eur J Pharmacol 2016 Nov 15;791:433-443 PMID: 27639297 PMCID: PMC5107132 SCOPUS ID: 2-s2.0-84988476311 10/30/2016       26 Citations
  • Characterization of GABAA receptor ligands with automated patch-clamp using human neurons derived from pluripotent stem cells. (Yuan NY, Poe MM, Witzigmann C, Cook JM, Stafford D, Arnold LA) J Pharmacol Toxicol Methods 2016;82:109-114 PMID: 27544543 PMCID: PMC5116268 SCOPUS ID: 2-s2.0-84989944608 10/18/2016       11 Citations
  • Total Synthesis of Macrocarpines D and E via an Enolate-Driven Copper-Mediated Cross-Coupling Process: Replacement of Catalytic Palladium with Copper Iodide. (Rahman MT, Deschamps JR, Imler GH, Schwabacher AW, Cook JM) Org Lett 2016 Sep 02;18(17):4174-7 PMID: 27526647 PMCID: PMC5298885 SCOPUS ID: 2-s2.0-84984920704 08/17/2016       19 Citations
  • First In Vivo Testing of Compounds Targeting Group 3 Medulloblastomas Using an Implantable Microdevice as a New Paradigm for Drug Development. (Jonas O, Calligaris D, Methuku KR, Poe MM, Francois JP, Tranghese F, Changelian A, Sieghart W, Ernst M, Krummel DA, Cook JM, Pomeroy SL, Cima M, Agar NY, Langer R, Sengupta S) J Biomed Nanotechnol 2016 Jun;12(6):1297-302 PMID: 27319222 PMCID: PMC5293728 SCOPUS ID: 2-s2.0-84964758617 06/21/2016       38 Citations
  • Development of GABAA Receptor Subtype-Selective Imidazobenzodiazepines as Novel Asthma Treatments. (Forkuo GS, Guthrie ML, Yuan NY, Nieman AN, Kodali R, Jahan R, Stephen MR, Yocum GT, Treven M, Poe MM, Li G, Yu OB, Hartzler BD, Zahn NM, Ernst M, Emala CW, Stafford DC, Cook JM, Arnold LA) Mol Pharm 2016 Jun 06;13(6):2026-38 PMID: 27120014 PMCID: PMC4899155 SCOPUS ID: 2-s2.0-84973661516 04/28/2016       26 Citations
  • Pharmacokinetic/Toxicity Properties of the New Anti-Staphylococcal Lead Compound SK-03-92. (Schwan WR, Kolesar JM, Kabir MS, Elder EJ Jr, Williams JB, Minerath R, Cook JM, Witzigmann CM, Monte A, Flaherty T) Antibiotics (Basel) 2015 Dec;4(4):617-626 PMID: 26877886 PMCID: PMC4748848 SCOPUS ID: 2-s2.0-85019808322 02/16/2016       2 Citations
  • Sarpagine and Related Alkaloids. (Namjoshi OA, Cook JM) Alkaloids Chem Biol 2016;76:63-169 PMID: 26827883 PMCID: PMC4864735 SCOPUS ID: 2-s2.0-84978621469 02/02/2016       47 Citations
  • Synthesis and evaluation of vitamin D receptor-mediated activities of cholesterol and vitamin D metabolites. (Teske KA, Bogart JW, Sanchez LM, Yu OB, Preston JV, Cook JM, Silvaggi NR, Bikle DD, Arnold LA) Eur J Med Chem 2016 Feb 15;109:238-46 PMID: 26774929 PMCID: PMC4737989 SCOPUS ID: 2-s2.0-84954311265 01/18/2016       16 Citations
  • Genetic and pharmacological manipulation of glyoxalase 1 regulates voluntary ethanol consumption in mice. (McMurray KM, Sidhu PS, Cook JM, Arnold LA, Palmer AA) Addict Biol 2017 Mar;22(2):381-389 PMID: 26691867 PMCID: PMC4917470 SCOPUS ID: 2-s2.0-84952333628 12/23/2015       9 Citations
  • A Review of the Updated Pharmacophore for the Alpha 5 GABA(A) Benzodiazepine Receptor Model. (Clayton T, Poe MM, Rallapalli S, Biawat P, Savić MM, Rowlett JK, Gallos G, Emala CW, Kaczorowski CC, Stafford DC, Arnold LA, Cook JM) Int J Med Chem 2015;2015:430248 PMID: 26682068 PMCID: PMC4657098 12/19/2015    
  • Corrigendum: Regulating anxiety with extrasynaptic inhibition. (Botta P, Demmou L, Kasugai Y, Markovic M, Xu C, Fadok JP, Lu T, Poe MM, Xu L, Cook JM, Rudolph U, Sah P, Ferraguti F, Lüthi A) Nat Neurosci 2015 Dec;18(12):1862 PMID: 26605888 SCOPUS ID: 2-s2.0-84948798805 11/26/2015       1 Citation
  • Antagonism of triazolam self-administration in rhesus monkeys responding under a progressive-ratio schedule: In vivo apparent pA2 analysis. (Fischer BD, Platt DM, Rallapalli SK, Namjoshi OA, Cook JM, Rowlett JK) Drug Alcohol Depend 2016 Jan 01;158:22-9 PMID: 26596587 PMCID: PMC4698084 SCOPUS ID: 2-s2.0-84952639509 11/26/2015       8 Citations
  • Antitumor Activity of 3-Indolylmethanamines 31B and PS121912. (Guthrie ML, Sidhu PS, Hill EK, Horan TC, Nandhikonda P, Teske KA, Yuan NY, Sidorko M, Rodali R, Cook JM, Han L, Silvaggi NR, Bikle DD, Moore RG, Singh RK, Arnold LA) Anticancer Res 2015 Nov;35(11):6001-7 PMID: 26504023 PMCID: PMC4633305 SCOPUS ID: 2-s2.0-84946067038 10/28/2015       7 Citations
  • Targeting the γ-Aminobutyric Acid A Receptor α4 Subunit in Airway Smooth Muscle to Alleviate Bronchoconstriction. (Yocum GT, Gallos G, Zhang Y, Jahan R, Stephen MR, Varagic Z, Puthenkalam R, Ernst M, Cook JM, Emala CW) Am J Respir Cell Mol Biol 2016 Apr;54(4):546-53 PMID: 26405827 PMCID: PMC4821055 SCOPUS ID: 2-s2.0-84963730425 09/26/2015       21 Citations
  • Synthesis of aza and carbocyclic β-carbolines for the treatment of alcohol abuse. Regiospecific solution to the problem of 3,6-disubstituted β- and aza-β-carboline specificity. (Phani Babu Tiruveedhula VV, Methuku KR, Deschamps JR, Cook JM) Org Biomol Chem 2015 Nov 21;13(43):10705-15 PMID: 26349488 PMCID: PMC4704088 SCOPUS ID: 2-s2.0-84946601118 09/10/2015       13 Citations
  • Regulating anxiety with extrasynaptic inhibition. (Botta P, Demmou L, Kasugai Y, Markovic M, Xu C, Fadok JP, Lu T, Poe MM, Xu L, Cook JM, Rudolph U, Sah P, Ferraguti F, Lüthi A) Nat Neurosci 2015 Oct;18(10):1493-500 PMID: 26322928 PMCID: PMC4607767 SCOPUS ID: 2-s2.0-84942409965 09/01/2015       132 Citations
  • Influence of a Nigerian honey on CYP3A4 biotransformation of quinine in healthy volunteers. (Igbinoba SI, Akanmu MA, Onyeji CO, Soyinka JO, Owolabi AR, Nathaniel TI, Pullela SV, Cook JM) J Clin Pharm Ther 2015 Oct;40(5):545-549 PMID: 26177778 PMCID: PMC4871767 SCOPUS ID: 2-s2.0-84940974540 07/17/2015    
  • Negative modulation of α₅ GABAA receptors in rats may partially prevent memory impairment induced by MK-801, but not amphetamine- or MK-801-elicited hyperlocomotion. (Timić Stamenić T, Joksimović S, Biawat P, Stanković T, Marković B, Cook JM, Savić MM) J Psychopharmacol 2015 Sep;29(9):1013-24 PMID: 26105958 PMCID: PMC4861997 SCOPUS ID: 2-s2.0-84942084235 06/25/2015       9 Citations
  • Selective targeting of the α5-subunit of GABAA receptors relaxes airway smooth muscle and inhibits cellular calcium handling. (Gallos G, Yocum GT, Siviski ME, Yim PD, Fu XW, Poe MM, Cook JM, Harrison N, Perez-Zoghbi J, Emala CW Sr) Am J Physiol Lung Cell Mol Physiol 2015 May 01;308(9):L931-42 PMID: 25659897 PMCID: PMC4421780 SCOPUS ID: 2-s2.0-84929662877 02/11/2015       41 Citations
  • Behavioral effects of the benzodiazepine-positive allosteric modulator SH-053-2'F-S-CH₃ in an immune-mediated neurodevelopmental disruption model. (Richetto J, Labouesse MA, Poe MM, Cook JM, Grace AA, Riva MA, Meyer U) Int J Neuropsychopharmacol 2015 Jan 30;18(4) PMID: 25636893 PMCID: PMC4360215 SCOPUS ID: 2-s2.0-84939160954 02/01/2015       22 Citations
  • Expression quantitative trait loci and receptor pharmacology implicate Arg1 and the GABA-A receptor as therapeutic targets in neuroblastoma. (Hackett CS, Quigley DA, Wong RA, Chen J, Cheng C, Song YK, Wei JS, Pawlikowska L, Bao Y, Goldenberg DD, Nguyen K, Gustafson WC, Rallapalli SK, Cho YJ, Cook JM, Kozlov S, Mao JH, Van Dyke T, Kwok PY, Khan J, Balmain A, Fan Q, Weiss WA) Cell Rep 2014 Nov 06;9(3):1034-46 PMID: 25437558 PMCID: PMC4251494 SCOPUS ID: 2-s2.0-84919718171 12/02/2014       21 Citations
  • IDENTIFICATION OF VDR ANTAGONISTS AMONG NUCLEAR RECEPTOR LIGANDS USING VIRTUAL SCREENING. (Teske K, Nandhikonda P, Bogart JW, Feleke B, Sidhu P, Yuan N, Preston J, Goy R, Han L, Silvaggi NR, Singh RK, Bikle DD, Cook JM, Arnold LA) Nucl Receptor Res 2014;1 PMID: 25419525 PMCID: PMC4240308 11/25/2014    
  • Effect of dehusked Garcinia kola seeds on the overall pharmacokinetics of quinine in healthy Nigerian volunteers. (Igbinoba SI, Onyeji CO, Akanmu MA, Soyinka JO, Pullela SS, Cook JM, Nathaniel TI) J Clin Pharmacol 2015 Mar;55(3):348-54 PMID: 25328082 PMCID: PMC4871276 SCOPUS ID: 2-s2.0-84960462235 10/21/2014       8 Citations
  • General strategy for synthesis of C-19 methyl-substituted sarpagine/macroline/ajmaline indole alkaloids including total synthesis of 19(S),20(R)-dihydroperaksine, 19(S),20(R)-dihydroperaksine-17-al, and peraksine. (Edwankar RV, Edwankar CR, Deschamps JR, Cook JM) J Org Chem 2014 Nov 07;79(21):10030-48 PMID: 25247616 PMCID: PMC4227583 SCOPUS ID: 2-s2.0-84910002249 09/24/2014       28 Citations
  • Anticancer activity of VDR-coregulator inhibitor PS121912. (Sidhu PS, Teske K, Feleke B, Yuan NY, Guthrie ML, Fernstrum GB, Vyas ND, Han L, Preston J, Bogart JW, Silvaggi NR, Cook JM, Singh RK, Bikle DD, Arnold LA) Cancer Chemother Pharmacol 2014 Oct;74(4):787-98 PMID: 25107568 PMCID: PMC4177010 SCOPUS ID: 2-s2.0-84939871260 08/12/2014       19 Citations
  • Development of novel Vitamin D Receptor-Coactivator Inhibitors. (Sidhu PS, Nassif N, McCallum MM, Teske K, Feleke B, Yuan NY, Nandhikonda P, Cook JM, Singh RK, Bikle DD, Arnold LA) ACS Med Chem Lett 2014 Feb 13;5(2):199-204 PMID: 24799995 PMCID: PMC4007349 SCOPUS ID: 2-s2.0-84894094945 05/07/2014       24 Citations
  • Stereospecific total synthesis of the indole alkaloid ervincidine. Establishment of the C-6 hydroxyl stereochemistry. (Rallapalli SK, Namjoshi OA, Tiruveedhula VV, Deschamps JR, Cook JM) J Org Chem 2014 May 02;79(9):3776-80 PMID: 24697213 PMCID: PMC4017614 SCOPUS ID: 2-s2.0-84899878754 04/05/2014       4 Citations
  • Duration of treatment and activation of α1-containing GABAA receptors variably affect the level of anxiety and seizure susceptibility after diazepam withdrawal in rats. (Kovačević J, Timić T, Tiruveedhula VV, Batinić B, Namjoshi OA, Milić M, Joksimović S, Cook JM, Savić MM) Brain Res Bull 2014 May;104:1-6 PMID: 24695241 PMCID: PMC4066304 SCOPUS ID: 2-s2.0-84898864077 04/04/2014       9 Citations
  • Glo1 inhibitors for neuropsychiatric and anti-epileptic drug development. (McMurray KM, Distler MG, Sidhu PS, Cook JM, Arnold LA, Palmer AA, Plant LD) Biochem Soc Trans 2014 Apr;42(2):461-7 PMID: 24646261 PMCID: PMC4036232 SCOPUS ID: 2-s2.0-84896922293 03/22/2014       19 Citations
  • Sh-I-048A, an in vitro non-selective super-agonist at the benzodiazepine site of GABAA receptors: the approximated activation of receptor subtypes may explain behavioral effects. (Obradović ALj, Joksimović S, Poe MM, Ramerstorfer J, Varagic Z, Namjoshi O, Batinić B, Radulović T, Marković B, Roth BL, Sieghart W, Cook JM, Savić MM) Brain Res 2014 Mar 20;1554:36-48 PMID: 24472579 PMCID: PMC3996760 SCOPUS ID: 2-s2.0-84895125288 01/30/2014       14 Citations
  • Prior antipsychotic drug treatment prevents response to novel antipsychotic agent in the methylazoxymethanol acetate model of schizophrenia. (Gill KM, Cook JM, Poe MM, Grace AA) Schizophr Bull 2014 Mar;40(2):341-50 PMID: 24464874 PMCID: PMC3932102 SCOPUS ID: 2-s2.0-84895724939 01/28/2014       52 Citations
  • Zebrafish heart failure models for the evaluation of chemical probes and drugs. (Huang CC, Monte A, Cook JM, Kabir MS, Peterson KP) Assay Drug Dev Technol 2013;11(9-10):561-72 PMID: 24351044 PMCID: PMC3870487 SCOPUS ID: 2-s2.0-84890936239 12/20/2013       39 Citations
  • Little evidence of a role for the α1GABAA subunit-containing receptor in a rhesus monkey model of alcohol drinking. (Sawyer EK, Moran C, Sirbu MH, Szafir M, Van Linn M, Namjoshi O, Phani Babu Tiruveedhula VV, Cook JM, Platt DM) Alcohol Clin Exp Res 2014 Apr;38(4):1108-17 PMID: 24330519 PMCID: PMC3984357 SCOPUS ID: 2-s2.0-84898042994 12/18/2013       10 Citations
  • Ethanol, not detectably metabolized in brain, significantly reduces brain metabolism, probably via action at specific GABA(A) receptors and has measureable metabolic effects at very low concentrations. (Rae CD, Davidson JE, Maher AD, Rowlands BD, Kashem MA, Nasrallah FA, Rallapalli SK, Cook JM, Balcar VJ) J Neurochem 2014 Apr;129(2):304-14 PMID: 24313287 PMCID: PMC3980046 SCOPUS ID: 2-s2.0-84897999517 12/10/2013       20 Citations
  • Design and synthesis of novel antimicrobials with activity against Gram-positive bacteria and mycobacterial species, including M. tuberculosis. (Tiruveedhula VV, Witzigmann CM, Verma R, Kabir MS, Rott M, Schwan WR, Medina-Bielski S, Lane M, Close W, Polanowski RL, Sherman D, Monte A, Deschamps JR, Cook JM) Bioorg Med Chem 2013 Dec 15;21(24):7830-40 PMID: 24200931 PMCID: PMC3860823 SCOPUS ID: 2-s2.0-84888435178 11/10/2013       9 Citations
  • α5-GABAA receptors negatively regulate MYC-amplified medulloblastoma growth. (Sengupta S, Weeraratne SD, Sun H, Phallen J, Rallapalli SK, Teider N, Kosaras B, Amani V, Pierre-Francois J, Tang Y, Nguyen B, Yu F, Schubert S, Balansay B, Mathios D, Lechpammer M, Archer TC, Tran P, Reimer RJ, Cook JM, Lim M, Jensen FE, Pomeroy SL, Cho YJ) Acta Neuropathol 2014 Apr;127(4):593-603 PMID: 24196163 PMCID: PMC3974267 SCOPUS ID: 2-s2.0-84896543307 11/08/2013       35 Citations
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