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Jennifer Strande MD, PhD

Jennifer Strande MD, PhD

Associate Professor

Institution: Medical College of Wisconsin
Department: Medicine
Division: Cardiology
Program: Administration

Member of the Cancer Center
Member of the Cardiovascular Center

Research Experience

  • Adult Stem Cells
  • Biomarkers
  • Cardiomegaly
  • Dystrophin
  • Echocardiography
  • Heart Diseases
  • Heart Failure
  • Heart Failure, Diastolic
  • Heart Failure, Systolic
  • Inflammation
  • Muscular Dystrophy, Duchenne
  • Myocardial Ischemia
  • Myocardial Reperfusion
  • Pluripotent Stem Cells
  • Receptor, PAR-1
  • Receptors, Proteinase-Activated
  • Receptors, Thrombin
  • Thrombin
  • muscular dystrophy
  • Clinical Expertise

  • Acute Coronary Syndrome
  • Angina, Unstable
  • Angiotensin-Converting Enzyme Inhibitors
  • Atherosclerosis
  • Cardiology
  • Cardiomegaly
  • Cardiomyopathy, Dilated
  • Coronary Occlusion
  • Coronary Thrombosis
  • Digoxin
  • Dobutamine
  • Dyspnea, Paroxysmal
  • Echocardiography
  • Edema, Cardiac
  • Heart Diseases
  • Heart Failure
  • Heart Failure, Diastolic
  • Heart Failure, Systolic
  • Myocardial Infarction
  • Myocardial Ischemia
  • Nitric Oxide Donors
  • Ventricular Dysfunction, Left
  • Ventricular Dysfunction, Right
  • Ventricular Remodeling
  • Methodologies and Techniques

  • Dystrophin
  • Fibroblasts
  • Fibrosis
  • Heart Failure
  • Induced Pluripotent Stem Cells
  • KATP Channels
  • Muscular Dystrophies
  • Muscular Dystrophy, Animal
  • Muscular Dystrophy, Duchenne
  • Myocardial Infarction
  • Myocardial Reperfusion Injury
  • Myocardium
  • Myocytes, Cardiac
  • Plasminogen Activator Inhibitor 1
  • Receptor, PAR-1
  • Ultrasonography
  • Leadership Positions

  • Chief Fellow in the Cardiovascular Medicine Fellowship Program (2009-2010)
  • Medical Director Echocardiography Research Core
  • MCW Program / Core Facilities

  • Small Animal Echocardiography Core Facitility
  • Publications

  • Mapping Genetic Modifiers of Radiation-Induced Cardiotoxicity to Rat Chromosome 3. (Schlaak RA, Frei A, Schottstaedt AM, Tsaih SW, Fish BL, Harmann L, Liu Q, Gasperetti T, Medhora MM, North PE, Strande JL, Sun Y, Rui H, Flister MJ, Bergom C) Am J Physiol Heart Circ Physiol 2019 Mar 08 PMID: 30848680 03/09/2019    
  • Cardiac Remodeling and Reversible Pulmonary Hypertension During Pneumonitis in Rats after 13-Gy Partial-Body Irradiation with Minimal Bone Marrow Sparing: Effect of Lisinopril. (Jacobs ER, Narayanan J, Fish BL, Gao F, Harmann LM, Bergom C, Gasperetti T, Strande JL, Medhora M) Health Phys 2019 Apr;116(4):558-565 PMID: 30624347 PMCID: PMC6384144 01/10/2019       2 Citations
  • Exosomes exert cardioprotection in dystrophin-deficient cardiomyocytes via ERK1/2-p38/MAPK signaling. (Gartz M, Darlington A, Afzal MZ, Strande JL) Sci Rep 2018 Nov 08;8(1):16519 PMID: 30410044 PMCID: PMC6224575 11/10/2018    
  • Examining the Paracrine Effects of Exosomes in Cardiovascular Disease and Repair. (Gartz M, Strande JL) J Am Heart Assoc 2018 Jun 01;7(11) PMID: 29858362 PMCID: PMC6015376 06/03/2018    
  • Epitope Mapping of SERCA2a Identifies an Antigenic Determinant That Induces Mainly Atrial Myocarditis in A/J Mice. (Krishnan B, Massilamany C, Basavalingappa RH, Gangaplara A, Rajasekaran RA, Afzal MZ, Khalilzad-Sharghi V, Zhou Y, Riethoven JJ, Nandi SS, Mishra PK, Sobel RA, Strande JL, Steffen D, Reddy J) J Immunol 2018 01 15;200(2):523-537 PMID: 29229678 PMCID: PMC5760440 12/13/2017    
  • β1-Adrenergic Receptor Contains Multiple IA and IE Binding Epitopes That Induce T Cell Responses with Varying Degrees of Autoimmune Myocarditis in A/J Mice. (Basavalingappa RH, Massilamany C, Krishnan B, Gangaplara A, Rajasekaran RA, Afzal MZ, Riethoven JJ, Strande JL, Steffen D, Reddy J) Front Immunol 2017;8:1567 PMID: 29209317 PMCID: PMC5701947 12/07/2017    
  • Bariatric surgery as a treatment for heart failure: review of the literature and potential mechanisms. (Kindel TL, Strande JL) Surg Obes Relat Dis 2018 01;14(1):117-122 PMID: 29108893 PMCID: PMC5748002 11/08/2017       1 Citations
  • Branched chain α-ketoacid dehydrogenase kinase 111-130, a T cell epitope that induces both autoimmune myocarditis and hepatitis in A/J mice. (Krishnan B, Massilamany C, Basavalingappa RH, Gangaplara A, Kang G, Li Q, Uzal FA, Strande JL, Delhon GA, Riethoven JJ, Steffen D, Reddy J) Immun Inflamm Dis 2017 12;5(4):421-434 PMID: 28597552 PMCID: PMC5691315 06/10/2017       2 Citations
  • Generation of human iPSCs from urine derived cells of a non-affected control subject. (Afzal MZ, Gartz M, Klyachko EA, Khan SS, Shah SJ, Gupta S, Shapiro AD, Vaughan DE, Strande JL) Stem Cell Res 2017 01;18:33-36 PMID: 28395799 PMCID: PMC5389122 04/12/2017       2 Citations
  • Generation of human iPSCs from urine derived cells of patient with a novel heterozygous PAI-1 mutation. (Afzal MZ, Gartz M, Klyachko EA, Khan SS, Shah SJ, Gupta S, Shapiro AD, Vaughan DE, Strande JL) Stem Cell Res 2017 01;18:41-44 PMID: 28395801 PMCID: PMC5939958 04/12/2017       2 Citations
  • Early Weight Loss Independent Effects of Sleeve Gastrectomy on Diet-Induced Cardiac Dysfunction in Obese, Wistar Rats. (Kindel TL, Foster T, Goldspink P, Kindel SJ, Corbett J, Widlanksy M, Strande J) Obes Surg 2017 09;27(9):2370-2377 PMID: 28299572 PMCID: PMC5937684 03/17/2017       1 Citations
  • Systemic AAV8-Mediated Gene Therapy Drives Whole-Body Correction of Myotubular Myopathy in Dogs. (Mack DL, Poulard K, Goddard MA, Latournerie V, Snyder JM, Grange RW, Elverman MR, Denard J, Veron P, Buscara L, Le Bec C, Hogrel JY, Brezovec AG, Meng H, Yang L, Liu F, O'Callaghan M, Gopal N, Kelly VE, Smith BK, Strande JL, Mavilio F, Beggs AH, Mingozzi F, Lawlor MW, Buj-Bello A, Childers MK) Mol Ther 2017 04 05;25(4):839-854 PMID: 28237839 PMCID: PMC5383631 02/27/2017       27 Citations
  • Molecular Approaches in HFpEF: MicroRNAs and iPSC-Derived Cardiomyocytes. (Kriegel AJ, Gartz M, Afzal MZ, de Lange WJ, Ralphe JC, Strande JL) J Cardiovasc Transl Res 2017 Jun;10(3):295-304 PMID: 28032312 PMCID: PMC5937699 12/30/2016       3 Citations
  • Generation of human iPSCs from urine derived cells of a patient with a novel homozygous PAI-1 mutation. (Afzal MZ, Gartz M, Klyachko EA, Khan SS, Shah SJ, Gupta S, Shapiro AD, Vaughan DE, Strande JL) Stem Cell Res 2016 11;17(3):657-660 PMID: 27934602 PMCID: PMC5409870 12/10/2016       1 Citations
  • Sucrose Nonfermenting-Related Kinase Enzyme-Mediated Rho-Associated Kinase Signaling is Responsible for Cardiac Function. (Cossette SM, Bhute VJ, Bao X, Harmann LM, Horswill MA, Sinha I, Gastonguay A, Pooya S, Bordas M, Kumar SN, Mirza SP, Palecek SP, Strande JL, Ramchandran R) Circ Cardiovasc Genet 2016 Dec;9(6):474-486 PMID: 27780848 PMCID: PMC5177517 10/27/2016       3 Citations
  • Nicorandil, a Nitric Oxide Donor and ATP-Sensitive Potassium Channel Opener, Protects Against Dystrophin-Deficient Cardiomyopathy. (Afzal MZ, Reiter M, Gastonguay C, McGivern JV, Guan X, Ge ZD, Mack DL, Childers MK, Ebert AD, Strande JL) J Cardiovasc Pharmacol Ther 2016 11;21(6):549-562 PMID: 26940570 PMCID: PMC5010518 03/05/2016       13 Citations
  • Combining patient proteomics and in vitro cardiomyocyte phenotype testing to identify potential mediators of heart failure with preserved ejection fraction. (Raphael R, Purushotham D, Gastonguay C, Chesnik MA, Kwok WM, Wu HE, Shah SJ, Mirza SP, Strande JL) J Transl Med 2016 Jan 20;14:18 PMID: 26792056 PMCID: PMC4719542 01/23/2016       7 Citations
  • Generation of induced pluripotent stem cells from muscular dystrophy patients: efficient integration-free reprogramming of urine derived cells. (Afzal MZ, Strande JL) J Vis Exp 2015 Jan 28(95):52032 PMID: 25650629 PMCID: PMC4354557 02/05/2015       12 Citations
  • Haploinsufficiency MYBPC3 mutations: another stress induced cardiomyopathy? Let's take a look! (Strande JL) J Mol Cell Cardiol 2015 Feb;79:284-6 PMID: 25524041 12/20/2014       3 Citations
  • Sucrose non-fermenting related kinase enzyme is essential for cardiac metabolism. (Cossette SM, Gastonguay AJ, Bao X, Lerch-Gaggl A, Zhong L, Harmann LM, Koceja C, Miao RQ, Vakeel P, Chun C, Li K, Foeckler J, Bordas M, Weiler H, Strande J, Palecek SP, Ramchandran R) Biol Open 2014 Dec 12;4(1):48-61 PMID: 25505152 PMCID: PMC4295165 12/17/2014    
  • Whole-thorax irradiation induces hypoxic respiratory failure, pleural effusions and cardiac remodeling. (Medhora M, Gao F, Glisch C, Narayanan J, Sharma A, Harmann LM, Lawlor MW, Snyder LA, Fish BL, Down JD, Moulder JE, Strande JL, Jacobs ER) J Radiat Res 2015 Mar;56(2):248-60 PMID: 25368342 PMCID: PMC4380043 11/05/2014       18 Citations
  • Dystrophin-deficient cardiomyocytes derived from human urine: new biologic reagents for drug discovery. (Guan X, Mack DL, Moreno CM, Strande JL, Mathieu J, Shi Y, Markert CD, Wang Z, Liu G, Lawlor MW, Moorefield EC, Jones TN, Fugate JA, Furth ME, Murry CE, Ruohola-Baker H, Zhang Y, Santana LF, Childers MK) Stem Cell Res 2014 Mar;12(2):467-80 PMID: 24434629 PMCID: PMC3966181 01/18/2014       43 Citations
  • Protease-activated receptor 1 inhibition by SCH79797 attenuates left ventricular remodeling and profibrotic activities of cardiac fibroblasts. (Sonin DL, Wakatsuki T, Routhu KV, Harmann LM, Petersen M, Meyer J, Strande JL) J Cardiovasc Pharmacol Ther 2013 Sep;18(5):460-75 PMID: 23598708 PMCID: PMC3771535 04/20/2013       32 Citations
  • Nerve growth factor reduces myocardial ischemia/reperfusion injury in rat hearts. (Strande JL, Routhu KV, Lecht S, Lazarovici P) J Basic Clin Physiol Pharmacol 2013;24(1):81-4 PMID: 23314533 PMCID: PMC3938895 01/15/2013    
  • Parstatin(1-26): the putative signal peptide of protease-activated receptor 1 confers potent protection from myocardial ischemia-reperfusion injury. (Routhu KV, Tsopanoglou NE, Strande JL) J Pharmacol Exp Ther 2010 Mar;332(3):898-905 PMID: 20008957 12/17/2009       13 Citations
  • Gadolinium decreases inflammation related to myocardial ischemia and reperfusion injury. (Strande JL, Routhu KV, Hsu A, Nicolosi AC, Baker JE) J Inflamm (Lond) 2009 Dec 10;6:34 PMID: 20003243 PMCID: PMC2799407 12/17/2009    
  • 10 Gy total body irradiation increases risk of coronary sclerosis, degeneration of heart structure and function in a rat model. (Baker JE, Fish BL, Su J, Haworth ST, Strande JL, Komorowski RA, Migrino RQ, Doppalapudi A, Harmann L, Allen Li X, Hopewell JW, Moulder JE) Int J Radiat Biol 2009 Dec;85(12):1089-100 PMID: 19995235 PMCID: PMC2792125 12/10/2009       60 Citations
  • Parstatin: a cryptic peptide involved in cardioprotection after ischaemia and reperfusion injury. (Strande JL, Widlansky ME, Tsopanoglou NE, Su J, Wang J, Hsu A, Routhu KV, Baker JE) Cardiovasc Res 2009 Jul 15;83(2):325-34 PMID: 19380418 PMCID: PMC2701720 04/22/2009       17 Citations
  • Thrombin increases inflammatory cytokine and angiogenic growth factor secretion in human adipose cells in vitro. (Strande JL, Phillips SA) J Inflamm (Lond) 2009 Mar 06;6:4 PMID: 19267924 PMCID: PMC2661073 03/10/2009    
  • Letter by Strande regarding article "Protease-activated receptor-1 contributes to cardiac remodeling and hypertrophy". (Strande JL) Circulation 2008 Jun 17;117(24):e495; author reply e496 PMID: 18559709 06/19/2008    
  • Gadolinium limits myocardial infarction in the rat: dose-response, temporal relations and mechanisms. (Nicolosi AC, Strande JL, Hsu A, Fu X, Su J, Gross GJ, Baker JE) J Mol Cell Cardiol 2008 Feb;44(2):345-51 PMID: 18083188 PMCID: PMC2322938 12/18/2007       9 Citations
  • Inhibiting protease-activated receptor 4 limits myocardial ischemia/reperfusion injury in rat hearts by unmasking adenosine signaling. (Strande JL, Hsu A, Su J, Fu X, Gross GJ, Baker JE) J Pharmacol Exp Ther 2008 Mar;324(3):1045-54 PMID: 18055876 PMCID: PMC2935083 12/07/2007       37 Citations
  • Human thrombopoietin reduces myocardial infarct size, apoptosis, and stunning following ischaemia/reperfusion in rats. (Baker JE, Su J, Hsu A, Shi Y, Zhao M, Strande JL, Fu X, Xu H, Eis A, Komorowski R, Jensen ES, Tweddell JS, Rafiee P, Gross GJ) Cardiovasc Res 2008 Jan;77(1):44-53 PMID: 18006466 PMCID: PMC2958050 11/17/2007       29 Citations
  • SCH 79797, a selective PAR1 antagonist, limits myocardial ischemia/reperfusion injury in rat hearts. (Strande JL, Hsu A, Su J, Fu X, Gross GJ, Baker JE) Basic Res Cardiol 2007 Jul;102(4):350-8 PMID: 17468933 PMCID: PMC3942648 05/01/2007       73 Citations
  • Neurogenesis is absent in the brains of adult honey bees and does not explain behavioral neuroplasticity. (Fahrbach SE, Strande JL, Robinson GE) Neurosci Lett 1995 Sep 08;197(2):145-8 PMID: 8552281 09/08/1995       81 Citations
  • Last update: 03/14/2019
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