Medical College of Wisconsin
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John A. Auchampach PhD

John A. Auchampach PhD

Professor

Institution: Medical College of Wisconsin
Department: Pharmacology and Toxicology
Program: Pharmacology

Member of the Cardiovascular Center


Research Experience

  • Adenosine
  • Cardiovascular Diseases
  • Heart Failure
  • Inflammation
  • Myocardial Infarction
  • Receptors, G-Protein-Coupled
  • Receptors, Purinergic P1
  • Regeneration
  • Signal Transduction
  • Publications (96)

  • Ability of CP-532,903 to protect mouse hearts from ischemia/reperfusion injury is dependent on expression of A adenosine receptors in cardiomyoyctes. (Wan TC, Tampo A, Kwok WM, Auchampach JA) Biochem Pharmacol 2019 May;163:21-31 PMID: 30710517 PMCID: PMC6470012 SCOPUS ID: 2-s2.0-85061006338 02/03/2019       2 Citations
  • Design and in Vivo Characterization of A Adenosine Receptor Agonists in the Native Ribose and Conformationally Constrained (N)-Methanocarba Series. (Tosh DK, Rao H, Bitant A, Salmaso V, Mannes P, Lieberman DI, Vaughan KL, Mattison JA, Rothwell AC, Auchampach JA, Ciancetta A, Liu N, Cui Z, Gao ZG, Reitman ML, Gavrilova O, Jacobson KA) J Med Chem 2019 Feb 14;62(3):1502-1522 PMID: 30605331 PMCID: PMC6467784 SCOPUS ID: 2-s2.0-85059756838 01/04/2019       1 Citation
  • Structure activity relationship of 2-arylalkynyl-adenine derivatives as human A adenosine receptor antagonists. (Yu J, Mannes P, Jung YH, Ciancetta A, Bitant A, Lieberman DI, Khaznadar S, Auchampach JA, Gao ZG, Jacobson KA) Medchemcomm 2018 Nov 01;9(11):1920-1932 PMID: 30568760 PMCID: PMC6256369 12/21/2018    
  • Repurposing of a Nucleoside Scaffold from Adenosine Receptor Agonists to Opioid Receptor Antagonists. (Tosh DK, Ciancetta A, Mannes P, Warnick E, Janowsky A, Eshleman AJ, Gizewski E, Brust TF, Bohn LM, Auchampach JA, Gao ZG, Jacobson KA) ACS Omega 2018 Oct 31;3(10):12658-12678 PMID: 30411015 PMCID: PMC6210068 11/10/2018    
  • IL-13 promotes in vivo neonatal cardiomyocyte cell cycle activity and heart regeneration. (Wodsedalek DJ, Paddock SJ, Wan TC, Auchampach JA, Kenarsary A, Tsaih SW, Flister MJ, O'Meara CC) Am J Physiol Heart Circ Physiol 2019 01 01;316(1):H24-H34 PMID: 30339498 SCOPUS ID: 2-s2.0-85060194313 10/20/2018       3 Citations
  • Activation of adenosine A or A receptors causes hypothermia in mice. (Carlin JL, Jain S, Duroux R, Suresh RR, Xiao C, Auchampach JA, Jacobson KA, Gavrilova O, Reitman ML) Neuropharmacology 2018 09 01;139:268-278 PMID: 29548686 PMCID: PMC6067974 SCOPUS ID: 2-s2.0-85043451256 03/20/2018       6 Citations
  • Bitopic fluorescent antagonists of the A adenosine receptor based on pyrazolo[4,3-][1,2,4]triazolo[1,5-]pyrimidin-5-amine functionalized congeners. (Duroux R, Ciancetta A, Mannes P, Yu J, Boyapati S, Gizewski E, Yous S, Ciruela F, Auchampach JA, Gao ZG, Jacobson KA) Medchemcomm 2017 Aug 01;8(8):1659-1667 PMID: 29250307 PMCID: PMC5729930 12/19/2017    
  • Species differences and mechanism of action of A adenosine receptor allosteric modulators. (Du L, Gao ZG, Paoletta S, Wan TC, Gizewski ET, Barbour S, van Veldhoven JPD, IJzerman AP, Jacobson KA, Auchampach JA) Purinergic Signal 2018 03;14(1):59-71 PMID: 29170977 PMCID: PMC5842153 SCOPUS ID: 2-s2.0-85034734757 11/25/2017       3 Citations
  • Bitopic fluorescent antagonists of the A2A adenosine receptor based on pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-5-amine functionalized congeners (Duroux R, Ciancetta A, Mannes P, Yu J, Boyapati S, Gizewski E, Yous S, Ciruela F, Auchampach JA, Gao ZG, Jacobson KA) Med Chem Commun 2017 June 20;8: 1659-1667 06/20/2017    
  • Scaffold Repurposing of Nucleosides (Adenosine Receptor Agonists): Enhanced Activity at the Human Dopamine and Norepinephrine Sodium Symporters. (Tosh DK, Janowsky A, Eshleman AJ, Warnick E, Gao ZG, Chen Z, Gizewski E, Auchampach JA, Salvemini D, Jacobson KA) J Med Chem 2017 04 13;60(7):3109-3123 PMID: 28319392 PMCID: PMC5501184 SCOPUS ID: 2-s2.0-85017530793 03/21/2017       9 Citations
  • Lung injury pathways: Adenosine receptor 2B signaling limits development of ischemic bronchiolitis obliterans organizing pneumonia. (Densmore JC, Schaid TR, Jeziorczak PM, Medhora M, Audi S, Nayak S, Auchampach J, Dwinell MR, Geurts AM, Jacobs ER) Exp Lung Res 2017 02;43(1):38-48 PMID: 28266889 PMCID: PMC5831175 SCOPUS ID: 2-s2.0-85014510215 03/08/2017       3 Citations
  • Bitopic fluorescent antagonists of the A 2A adenosine receptor based on pyrazolo[4,3-: E] [1,2,4]triazolo[1,5- c] pyrimidin-5-amine functionalized congeners (Duroux R, Ciancetta A, Mannes P, Yu J, Boyapati S, Gizewski E, Yous S, Ciruela F, Auchampach JA, Gao ZG, Jacobson KA) MedChemComm 2017;8(8):1659-1667 SCOPUS ID: 2-s2.0-85027529790 01/01/2017    
  • Hypothermia in mouse is caused by adenosine A and A receptor agonists and AMP via three distinct mechanisms. (Carlin JL, Jain S, Gizewski E, Wan TC, Tosh DK, Xiao C, Auchampach JA, Jacobson KA, Gavrilova O, Reitman ML) Neuropharmacology 2017 03 01;114:101-113 PMID: 27914963 PMCID: PMC5183552 SCOPUS ID: 2-s2.0-85002410442 12/05/2016       22 Citations
  • Depletion of Tip60 from In Vivo Cardiomyocytes Increases Myocyte Density, Followed by Cardiac Dysfunction, Myocyte Fallout and Lethality. (Fisher JB, Horst A, Wan T, Kim MS, Auchampach J, Lough J) PLoS One 2016;11(10):e0164855 PMID: 27768769 PMCID: PMC5074524 SCOPUS ID: 2-s2.0-84992386888 10/22/2016       3 Citations
  • Purine (N)-Methanocarba Nucleoside Derivatives Lacking an Exocyclic Amine as Selective A3 Adenosine Receptor Agonists. (Tosh DK, Ciancetta A, Warnick E, O'Connor R, Chen Z, Gizewski E, Crane S, Gao ZG, Auchampach JA, Salvemini D, Jacobson KA) J Med Chem 2016 Apr 14;59(7):3249-63 PMID: 26890707 PMCID: PMC4970510 SCOPUS ID: 2-s2.0-84966397565 02/19/2016       8 Citations
  • Characterization of Dahl salt-sensitive rats with genetic disruption of the A2B adenosine receptor gene: implications for A2B adenosine receptor signaling during hypertension. (Nayak S, Khan MA, Wan TC, Pei H, Linden J, Dwinell MR, Geurts AM, Imig JD, Auchampach JA) Purinergic Signal 2015 Dec;11(4):519-31 PMID: 26385692 PMCID: PMC4648794 SCOPUS ID: 2-s2.0-84947616348 09/20/2015       5 Citations
  • Structure-Based Design, Synthesis by Click Chemistry and Activity of Highly Selective A Adenosine Receptor Agonists. (Tosh DK, Paoletta S, Chen Z, Crane S, Lloyd J, Gao ZG, Gizewski ET, Auchampach JA, Salvemini D, Jacobson KA) Medchemcomm 2015;6:555-563 PMID: 26236460 PMCID: PMC4517612 08/04/2015    
  • Rigidified A3 Adenosine Receptor Agonists: 1-Deazaadenine Modification Maintains High in Vivo Efficacy. (Tosh DK, Crane S, Chen Z, Paoletta S, Gao ZG, Gizewski E, Auchampach JA, Salvemini D, Jacobson KA) ACS Med Chem Lett 2015 Jul 09;6(7):804-8 PMID: 26191370 PMCID: PMC4499829 07/21/2015    
  • Structure-based design, synthesis by click chemistry and in vivo activity of highly selective A3 adenosine receptor agonists (Tosh DK, Paoletta S, Chen Z, Crane S, Lloyd J, Gao ZG, Gizewski ET, Auchampach JA, Salvemini D, Jacobson KA) MedChemComm 1 April 2015;6(4):555-563 SCOPUS ID: 2-s2.0-84928006881 04/01/2015    
  • In vivo phenotypic screening for treating chronic neuropathic pain: modification of C2-arylethynyl group of conformationally constrained A3 adenosine receptor agonists. (Tosh DK, Finley A, Paoletta S, Moss SM, Gao ZG, Gizewski ET, Auchampach JA, Salvemini D, Jacobson KA) J Med Chem 2014 Dec 11;57(23):9901-14 PMID: 25422861 PMCID: PMC4266358 SCOPUS ID: 2-s2.0-84918572262 11/26/2014       30 Citations
  • Rap1b in smooth muscle and endothelium is required for maintenance of vascular tone and normal blood pressure. (Lakshmikanthan S, Zieba BJ, Ge ZD, Momotani K, Zheng X, Lund H, Artamonov MV, Maas JE, Szabo A, Zhang DX, Auchampach JA, Mattson DL, Somlyo AV, Chrzanowska-Wodnicka M) Arterioscler Thromb Vasc Biol 2014 Jul;34(7):1486-94 PMID: 24790136 PMCID: PMC4224284 SCOPUS ID: 2-s2.0-84903159007 05/03/2014       23 Citations
  • Effect of human 15-lipoxygenase-1 metabolites on vascular function in mouse mesenteric arteries and hearts. (Kriska T, Cepura C, Siangjong L, Wan TC, Auchampach JA, Shaish A, Haratz D, Kumar G, Falck JR, Gauthier KM, Campbell WB) Prostaglandins Other Lipid Mediat 2013 Oct;106:8-15 PMID: 23872364 PMCID: PMC3844054 SCOPUS ID: 2-s2.0-84883361018 07/23/2013       5 Citations
  • Rational design of sulfonated A3 adenosine receptor-selective nucleosides as pharmacological tools to study chronic neuropathic pain. (Paoletta S, Tosh DK, Finley A, Gizewski ET, Moss SM, Gao ZG, Auchampach JA, Salvemini D, Jacobson KA) J Med Chem 2013 Jul 25;56(14):5949-63 PMID: 23789857 PMCID: PMC3858399 SCOPUS ID: 2-s2.0-84880866056 06/25/2013       28 Citations
  • An adenosine-mediated signaling pathway suppresses prenylation of the GTPase Rap1B and promotes cell scattering. (Ntantie E, Gonyo P, Lorimer EL, Hauser AD, Schuld N, McAllister D, Kalyanaraman B, Dwinell MB, Auchampach JA, Williams CL) Sci Signal 2013 May 28;6(277):ra39 PMID: 23716716 PMCID: PMC4278376 SCOPUS ID: 2-s2.0-84878725519 05/30/2013       51 Citations
  • Characterization by flow cytometry of fluorescent, selective agonist probes of the A(3) adenosine receptor. (Kozma E, Gizewski ET, Tosh DK, Squarcialupi L, Auchampach JA, Jacobson KA) Biochem Pharmacol 2013 Apr 15;85(8):1171-81 PMID: 23376019 PMCID: PMC3604185 SCOPUS ID: 2-s2.0-84875225899 02/05/2013       12 Citations
  • Adenosine A1 receptors heterodimerize with β1- and β2-adrenergic receptors creating novel receptor complexes with altered G protein coupling and signaling. (Chandrasekera PC, Wan TC, Gizewski ET, Auchampach JA, Lasley RD) Cell Signal 2013 Apr;25(4):736-42 PMID: 23291003 PMCID: PMC3896953 SCOPUS ID: 2-s2.0-84873252073 01/08/2013       26 Citations
  • Structure-guided design of A(3) adenosine receptor-selective nucleosides: combination of 2-arylethynyl and bicyclo[3.1.0]hexane substitutions. (Tosh DK, Deflorian F, Phan K, Gao ZG, Wan TC, Gizewski E, Auchampach JA, Jacobson KA) J Med Chem 2012 May 24;55(10):4847-60 PMID: 22559880 PMCID: PMC3371665 SCOPUS ID: 2-s2.0-84861499550 05/09/2012       58 Citations
  • Stress-induced cell-cycle activation in Tip60 haploinsufficient adult cardiomyocytes. (Fisher JB, Kim MS, Blinka S, Ge ZD, Wan T, Duris C, Christian D, Twaroski K, North P, Auchampach J, Lough J) PLoS One 2012;7(2):e31569 PMID: 22348108 PMCID: PMC3279378 SCOPUS ID: 2-s2.0-84863165939 02/22/2012       9 Citations
  • Polyamidoamine (PAMAM) dendrimer conjugate specifically activates the A3 adenosine receptor to improve post-ischemic/reperfusion function in isolated mouse hearts. (Wan TC, Tosh DK, Du L, Gizewski ET, Jacobson KA, Auchampach JA) BMC Pharmacol 2011 Oct 31;11:11 PMID: 22039965 PMCID: PMC3247180 SCOPUS ID: 2-s2.0-80055018439 11/02/2011       19 Citations
  • Protection from myocardial ischemia/reperfusion injury by a positive allosteric modulator of the A₃ adenosine receptor. (Du L, Gao ZG, Nithipatikom K, Ijzerman AP, Veldhoven JP, Jacobson KA, Gross GJ, Auchampach JA) J Pharmacol Exp Ther 2012 Jan;340(1):210-7 PMID: 22011434 PMCID: PMC3251031 SCOPUS ID: 2-s2.0-84055178004 10/21/2011       19 Citations
  • A role for the low-affinity A2B adenosine receptor in regulating superoxide generation by murine neutrophils. (van der Hoeven D, Wan TC, Gizewski ET, Kreckler LM, Maas JE, Van Orman J, Ravid K, Auchampach JA) J Pharmacol Exp Ther 2011 Sep;338(3):1004-12 PMID: 21693629 PMCID: PMC3164346 SCOPUS ID: 2-s2.0-80052168465 06/23/2011       33 Citations
  • Characterization of a critical role for CFTR chloride channels in cardioprotection against ischemia/reperfusion injury. (Xiang SY, Ye LL, Duan LL, Liu LH, Ge ZD, Auchampach JA, Gross GJ, Duan DD) Acta Pharmacol Sin 2011 Jun;32(6):824-33 PMID: 21642951 PMCID: PMC3217336 SCOPUS ID: 2-s2.0-79958088887 06/07/2011       12 Citations
  • Are we putting too much stock in mice? (Auchampach JA, Maas JE, Wan TC, Figler RA, Gross GJ) J Mol Cell Cardiol 2011 Mar;50(3):584-5 PMID: 21129379 SCOPUS ID: 2-s2.0-79551593927 12/07/2010    
  • Cardiovascular biology of the A3 adenosine receptor (Headrick JP, Peart JN, Wan TC, Kwok WM, Auchampach JA) A3 Adenosine Receptors from Cell Biology to Pharmacology and Therapeutics 2010:189-208 SCOPUS ID: 2-s2.0-84900067616 12/01/2010    
  • Evidence that the acute phase of ischemic preconditioning does not require signaling by the A 2B adenosine receptor. (Maas JE, Wan TC, Figler RA, Gross GJ, Auchampach JA) J Mol Cell Cardiol 2010 Nov;49(5):886-93 PMID: 20797398 PMCID: PMC2958103 SCOPUS ID: 2-s2.0-77957236611 08/28/2010       24 Citations
  • Activation of the A(3) adenosine receptor inhibits fMLP-induced Rac activation in mouse bone marrow neutrophils. (van der Hoeven D, Gizewski ET, Auchampach JA) Biochem Pharmacol 2010 Jun 01;79(11):1667-73 PMID: 20149782 PMCID: PMC2847012 SCOPUS ID: 2-s2.0-77950087794 02/13/2010       8 Citations
  • A(3) adenosine receptor activation during reperfusion reduces infarct size through actions on bone marrow-derived cells. (Ge ZD, van der Hoeven D, Maas JE, Wan TC, Auchampach JA) J Mol Cell Cardiol 2010 Aug;49(2):280-6 PMID: 20132822 PMCID: PMC2885516 SCOPUS ID: 2-s2.0-77953713842 02/06/2010       36 Citations
  • Isoflurane postconditioning protects against reperfusion injury by preventing mitochondrial permeability transition by an endothelial nitric oxide synthase-dependent mechanism. (Ge ZD, Pravdic D, Bienengraeber M, Pratt PF Jr, Auchampach JA, Gross GJ, Kersten JR, Warltier DC) Anesthesiology 2010 Jan;112(1):73-85 PMID: 19996950 PMCID: PMC4374483 SCOPUS ID: 2-s2.0-74049154710 12/10/2009       68 Citations
  • Synthesis and pharmacological characterization of [(125)I]MRS5127, a high affinity, selective agonist radioligand for the A3 adenosine receptor. (Auchampach JA, Gizewski ET, Wan TC, de Castro S, Brown GG Jr, Jacobson KA) Biochem Pharmacol 2010 Apr 01;79(7):967-73 PMID: 19917269 PMCID: PMC2815200 SCOPUS ID: 2-s2.0-77449155693 11/18/2009       14 Citations
  • Adenosine suppresses lipopolysaccharide-induced tumor necrosis factor-alpha production by murine macrophages through a protein kinase A- and exchange protein activated by cAMP-independent signaling pathway. (Kreckler LM, Gizewski E, Wan TC, Auchampach JA) J Pharmacol Exp Ther 2009 Dec;331(3):1051-61 PMID: 19749080 PMCID: PMC2784717 SCOPUS ID: 2-s2.0-73349106518 09/15/2009       32 Citations
  • Characterization of the A2B adenosine receptor from mouse, rabbit, and dog. (Auchampach JA, Kreckler LM, Wan TC, Maas JE, van der Hoeven D, Gizewski E, Narayanan J, Maas GE) J Pharmacol Exp Ther 2009 Apr;329(1):2-13 PMID: 19141710 PMCID: PMC2670590 SCOPUS ID: 2-s2.0-63849116251 01/15/2009       31 Citations
  • Mediation of cannabidiol anti-inflammation in the retina by equilibrative nucleoside transporter and A2A adenosine receptor. (Liou GI, Auchampach JA, Hillard CJ, Zhu G, Yousufzai B, Mian S, Khan S, Khalifa Y) Invest Ophthalmol Vis Sci 2008 Dec;49(12):5526-31 PMID: 18641283 PMCID: PMC2588644 SCOPUS ID: 2-s2.0-58149269741 07/22/2008       71 Citations
  • Activation of the A(3) adenosine receptor suppresses superoxide production and chemotaxis of mouse bone marrow neutrophils. (van der Hoeven D, Wan TC, Auchampach JA) Mol Pharmacol 2008 Sep;74(3):685-96 PMID: 18583455 PMCID: PMC2574951 SCOPUS ID: 2-s2.0-50449094182 06/28/2008       58 Citations
  • Design of (N)-methanocarba adenosine 5'-uronamides as species-independent A3 receptor-selective agonists. (Melman A, Gao ZG, Kumar D, Wan TC, Gizewski E, Auchampach JA, Jacobson KA) Bioorg Med Chem Lett 2008 May 01;18(9):2813-9 PMID: 18424135 PMCID: PMC2430186 SCOPUS ID: 2-s2.0-42949156868 04/22/2008       36 Citations
  • Adenosine receptors and angiogenesis. (Auchampach JA) Circ Res 2007 Nov 26;101(11):1075-7 PMID: 18040023 PMCID: PMC2399891 SCOPUS ID: 2-s2.0-36349018293 11/28/2007       40 Citations
  • The A3 adenosine receptor agonist CP-532,903 [N6-(2,5-dichlorobenzyl)-3'-aminoadenosine-5'-N-methylcarboxamide] protects against myocardial ischemia/reperfusion injury via the sarcolemmal ATP-sensitive potassium channel. (Wan TC, Ge ZD, Tampo A, Mio Y, Bienengraeber MW, Tracey WR, Gross GJ, Kwok WM, Auchampach JA) J Pharmacol Exp Ther 2008 Jan;324(1):234-43 PMID: 17906066 PMCID: PMC2435594 SCOPUS ID: 2-s2.0-37349025060 10/02/2007       64 Citations
  • Reperfusion injury: does it exist? (Gross GJ, Auchampach JA) J Mol Cell Cardiol 2007 Jan;42(1):12-8 PMID: 17069848 PMCID: PMC1876792 SCOPUS ID: 2-s2.0-33845675393 10/31/2006       97 Citations
  • Improved cardiac function in infarcted mice after treatment with pluripotent embryonic stem cells. (Nelson TJ, Ge ZD, Van Orman J, Barron M, Rudy-Reil D, Hacker TA, Misra R, Duncan SA, Auchampach JA, Lough JW) Anat Rec A Discov Mol Cell Evol Biol 2006 Nov;288(11):1216-24 PMID: 17004246 PMCID: PMC2566533 SCOPUS ID: 2-s2.0-33750532546 09/28/2006       48 Citations
  • Cl-IB-MECA [2-chloro-N6-(3-iodobenzyl)adenosine-5'-N-methylcarboxamide] reduces ischemia/reperfusion injury in mice by activating the A3 adenosine receptor. (Ge ZD, Peart JN, Kreckler LM, Wan TC, Jacobson MA, Gross GJ, Auchampach JA) J Pharmacol Exp Ther 2006 Dec;319(3):1200-10 PMID: 16985166 SCOPUS ID: 2-s2.0-33751189857 09/21/2006       78 Citations
  • Inhibition of an equilibrative nucleoside transporter by cannabidiol: a mechanism of cannabinoid immunosuppression. (Carrier EJ, Auchampach JA, Hillard CJ) Proc Natl Acad Sci U S A 2006 May 16;103(20):7895-900 PMID: 16672367 PMCID: PMC1472541 SCOPUS ID: 2-s2.0-33646734889 05/05/2006       233 Citations
  • Adenosine inhibits tumor necrosis factor-alpha release from mouse peritoneal macrophages via A2A and A2B but not the A3 adenosine receptor. (Kreckler LM, Wan TC, Ge ZD, Auchampach JA) J Pharmacol Exp Ther 2006 Apr;317(1):172-80 PMID: 16339914 SCOPUS ID: 2-s2.0-33645115158 12/13/2005       136 Citations
  • Extending the cardioprotective window using a novel delta-opioid agonist fentanyl isothiocyanate via the PI3-kinase pathway. (Gross ER, Peart JN, Hsu AK, Auchampach JA, Gross GJ) Am J Physiol Heart Circ Physiol 2005 Jun;288(6):H2744-9 PMID: 15653765 SCOPUS ID: 2-s2.0-19344369007 01/18/2005       47 Citations
  • Gene dose-dependent atrial arrhythmias, heart block, and brady-cardiomyopathy in mice overexpressing A(3) adenosine receptors. (Fabritz L, Kirchhof P, Fortmüller L, Auchampach JA, Baba HA, Breithardt G, Neumann J, Boknik P, Schmitz W) Cardiovasc Res 2004 Jun 01;62(3):500-8 PMID: 15158142 PMCID: PMC3910327 SCOPUS ID: 2-s2.0-2442436385 05/26/2004       40 Citations
  • Comparison of three different A1 adenosine receptor antagonists on infarct size and multiple cycle ischemic preconditioning in anesthetized dogs. (Auchampach JA, Jin X, Moore J, Wan TC, Kreckler LM, Ge ZD, Narayanan J, Whalley E, Kiesman W, Ticho B, Smits G, Gross GJ) J Pharmacol Exp Ther 2004 Mar;308(3):846-56 PMID: 14634049 SCOPUS ID: 2-s2.0-10744233575 11/25/2003       41 Citations
  • A3 adenosine receptor agonist IB-MECA reduces myocardial ischemia-reperfusion injury in dogs. (Auchampach JA, Ge ZD, Wan TC, Moore J, Gross GJ) Am J Physiol Heart Circ Physiol 2003 Aug;285(2):H607-13 PMID: 12689858 PMCID: PMC3860822 SCOPUS ID: 2-s2.0-0037962234 04/12/2003       64 Citations
  • Renal effects of BG9928, an A1 adenosine receptor antagonist, in rats and nonhuman primates (Ticho B, Whalley E, Gill A, Lutterodt F, Jin X, Auchampach J, Smits G) Drug Development Research 1 April 2003;58(4):486-492 SCOPUS ID: 2-s2.0-0038049149 04/01/2003    
  • Comparison of cardioprotective efficacy of two thromboxane A2 receptor antagonists. (Ge ZD, Auchampach JA, Piper GM, Gross GJ) J Cardiovasc Pharmacol 2003 Mar;41(3):481-8 PMID: 12605028 SCOPUS ID: 2-s2.0-0037369542 02/27/2003       10 Citations
  • Overexpression of A(3) adenosine receptors decreases heart rate, preserves energetics, and protects ischemic hearts. (Cross HR, Murphy E, Black RG, Auchampach J, Steenbergen C) Am J Physiol Heart Circ Physiol 2002 Oct;283(4):H1562-8 PMID: 12234810 PMCID: PMC3934563 SCOPUS ID: 2-s2.0-0036783615 09/18/2002       56 Citations
  • Therapeutic receptor targets of ischemic preconditioning. (Fryer RM, Auchampach JA, Gross GJ) Cardiovasc Res 2002 Aug 15;55(3):520-5 PMID: 12160948 PMCID: PMC3864592 SCOPUS ID: 2-s2.0-0036023623 08/06/2002       61 Citations
  • Gene dosage-dependent effects of cardiac-specific overexpression of the A3 adenosine receptor. (Black RG Jr, Guo Y, Ge ZD, Murphree SS, Prabhu SD, Jones WK, Bolli R, Auchampach JA) Circ Res 2002 Jul 26;91(2):165-72 PMID: 12142350 PMCID: PMC3682827 SCOPUS ID: 2-s2.0-0037178739 07/27/2002       74 Citations
  • Protection of IB-MECA against myocardial stunning in conscious rabbits is not mediated by the A1 adenosine receptor. (Kodani E, Bolli R, Tang XL, Auchampach JA) Basic Res Cardiol 2001 Sep;96(5):487-96 PMID: 11605996 SCOPUS ID: 2-s2.0-0035689236 10/19/2001       18 Citations
  • Cyclooxygenase-2 does not mediate late preconditioning induced by activation of adenosine A1 or A3 receptors. (Kodani E, Shinmura K, Xuan YT, Takano H, Auchampach JA, Tang XL, Bolli R) Am J Physiol Heart Circ Physiol 2001 Aug;281(2):H959-68 PMID: 11454603 SCOPUS ID: 2-s2.0-0034880998 07/17/2001       32 Citations
  • Targeted deletion of the A3 adenosine receptor confers resistance to myocardial ischemic injury and does not prevent early preconditioning. (Guo Y, Bolli R, Bao W, Wu WJ, Black RG Jr, Murphree SS, Salvatore CA, Jacobson MA, Auchampach JA) J Mol Cell Cardiol 2001 Apr;33(4):825-30 PMID: 11273734 PMCID: PMC4100593 SCOPUS ID: 2-s2.0-0034743562 03/29/2001       68 Citations
  • A(1) or A(3) adenosine receptors induce late preconditioning against infarction in conscious rabbits by different mechanisms. (Takano H, Bolli R, Black RG Jr, Kodani E, Tang XL, Yang Z, Bhattacharya S, Auchampach JA) Circ Res 2001 Mar 16;88(5):520-8 PMID: 11249876 SCOPUS ID: 2-s2.0-0035896182 03/16/2001       106 Citations
  • Na(+)/H(+) exchange inhibition-induced cardioprotection in dogs: effects on neutrophils versus cardiomyocytes. (Gumina RJ, Auchampach J, Wang R, Buerger E, Eickmeier C, Moore J, Daemmgen J, Gross GJ) Am J Physiol Heart Circ Physiol 2000 Oct;279(4):H1563-70 PMID: 11009442 SCOPUS ID: 2-s2.0-0033712090 09/29/2000       48 Citations
  • A(3) adenosine receptor activation attenuates neutrophil function and neutrophil-mediated reperfusion injury. (Jordan JE, Thourani VH, Auchampach JA, Robinson JA, Wang NP, Vinten-Johansen J) Am J Physiol 1999 11;277(5):H1895-905 PMID: 10564145 SCOPUS ID: 2-s2.0-0032712049 11/24/1999       83 Citations
  • PKC-dependent activation of p44/p42 MAPKs during myocardial ischemia-reperfusion in conscious rabbits. (Ping P, Zhang J, Cao X, Li RC, Kong D, Tang XL, Qiu Y, Manchikalapudi S, Auchampach JA, Black RG, Bolli R) Am J Physiol 1999 05;276(5):H1468-81 PMID: 10330229 SCOPUS ID: 2-s2.0-0032993140 05/18/1999       205 Citations
  • Adenosine receptor subtypes in the heart: therapeutic opportunities and challenges. (Auchampach JA, Bolli R) Am J Physiol 1999 03;276(3):H1113-6 PMID: 10070100 SCOPUS ID: 2-s2.0-0032925214 03/10/1999       54 Citations
  • Effect of the platelet-activating factor antagonist RP 59227 (Tulopafant) on myocardial ischemia/reperfusion injury and neutrophil function. (Auchampach JA, Pieper GM, Cavero I, Gross GJ) Basic Res Cardiol 1998 Oct;93(5):361-71 PMID: 9833148 SCOPUS ID: 2-s2.0-0031739214 12/02/1998       16 Citations
  • Early and Late Preconditioning Against Myocardial Stunning: Pathogenesis and Pathophysiology (Auchampach JA, Tang XL, Qiu Y, Ping P, Bolli R) Advances in Organ Biology 1998;6(C):125-138 SCOPUS ID: 2-s2.0-77956792981 12/01/1998    
  • The structure and function of A1 and A2B adenosine receptors. (Linden J, Auchampach JA, Jin X, Figler RA) Life Sci 1998;62(17-18):1519-24 PMID: 9585129 SCOPUS ID: 2-s2.0-0032571017 05/19/1998       41 Citations
  • Canine mast cell adenosine receptors: cloning and expression of the A3 receptor and evidence that degranulation is mediated by the A2B receptor. (Auchampach JA, Jin X, Wan TC, Caughey GH, Linden J) Mol Pharmacol 1997 Nov;52(5):846-60 PMID: 9351976 SCOPUS ID: 2-s2.0-0030817408 11/14/1997       169 Citations
  • Role of adenosine receptors in late preconditioning against myocardial stunning in conscious rabbits. (Maldonado C, Qiu Y, Tang XL, Cohen MV, Auchampach J, Bolli R) Am J Physiol 1997 Sep;273(3 Pt 2):H1324-32 PMID: 9321822 SCOPUS ID: 2-s2.0-33751268691 10/10/1997       50 Citations
  • Selective activation of A3 adenosine receptors with N6-(3-iodobenzyl)adenosine-5'-N-methyluronamide protects against myocardial stunning and infarction without hemodynamic changes in conscious rabbits. (Auchampach JA, Rizvi A, Qiu Y, Tang XL, Maldonado C, Teschner S, Bolli R) Circ Res 1997 Jun;80(6):800-9 PMID: 9168782 SCOPUS ID: 2-s2.0-0030612660 06/01/1997       153 Citations
  • Adenosine receptors (Luthin DR, Auchampach JA, Linden J) Biomembranes: A Multi-Volume Treatise 1996;2(C):321-347 SCOPUS ID: 2-s2.0-77957031950 12/01/1996    
  • PD 81,723, an allosteric enhancer of the A1 adenosine receptor, lowers the threshold for ischemic preconditioning in dogs. (Mizumura T, Auchampach JA, Linden J, Bruns RF, Gross GJ) Circ Res 1996 Sep;79(3):415-23 PMID: 8781475 09/01/1996    
  • PD 81,723, an allosteric enhancer of the A1 adenosine receptor, lowers the threshold for ischemic preconditioning in dogs (Mizumura T, Auchampach JA, Linden J, Bruns RF, Gross GJ) Circulation Research 1996;79(3):415-423 SCOPUS ID: 2-s2.0-0029816510 01/01/1996    
  • Cloning of a canine cDNA homologous to the human transforming growth factor-beta 1-encoding gene. (Manning AM, Auchampach JA, Drong RF, Slightom JL) Gene 1995 Apr 03;155(2):307-8 PMID: 7721110 SCOPUS ID: 2-s2.0-0028948805 04/03/1995       9 Citations
  • Attenuation of oxidant-induced lung injury by 21-aminosteroids (lazaroids): correlation with the mRNA expression for E-selectin, P-selectin, ICAM-1, and VCAM-1. (Griffin RL, Krzesicki RF, Fidler SF, Rosenbloom CL, Auchampach JA, Manning AM, Haas JV, Cammarata SK, Chin JE, Richards IM) Environ Health Perspect 1994 Dec;102 Suppl 10:193-200 PMID: 7535686 PMCID: PMC1567004 SCOPUS ID: 2-s2.0-0028575737 12/01/1994       24 Citations
  • Cloning, sequence comparison and in vivo expression of the gene encoding rat P-selectin. (Auchampach JA, Oliver MG, Anderson DC, Manning AM) Gene 1994 Aug 05;145(2):251-5 PMID: 7520013 SCOPUS ID: 2-s2.0-0028107854 08/05/1994       35 Citations
  • Cardioprotective actions of potassium channel openers. (Auchampach JA, Maruyama M, Gross GJ) Eur Heart J 1994 Aug;15 Suppl C:89-94 PMID: 7995278 SCOPUS ID: 2-s2.0-0028000768 08/01/1994       23 Citations
  • The ATP-regulated potassium channel in ischemia-reperfusion injury. (Gross GJ, Yao Z, Pieper GM, Auchampach JA) Ann N Y Acad Sci 1994 Jun 17;723:71-81 PMID: 8030926 SCOPUS ID: 2-s2.0-0028306191 06/17/1994       24 Citations
  • The ATP-Regulated Potassium Channel in Ischemia-Reperfusion Injury. (Gross GJ, Yao Z, Pieper GM, Auchampach JA) Ann N Y Acad Sci 1994 Jun;723(1):71-81 PMID: 28984968 06/01/1994    
  • Reduction in myocardial infarct size by the new potassium channel opener bimakalim. (Auchampach JA, Gross GJ) J Cardiovasc Pharmacol 1994 Apr;23(4):554-61 PMID: 7516004 SCOPUS ID: 2-s2.0-0028202074 04/01/1994       34 Citations
  • In vitro activation of brain protein kinase C by the cannabinoids. (Hillard CJ, Auchampach JA) Biochim Biophys Acta 1994 Jan 13;1220(2):163-70 PMID: 8312360 SCOPUS ID: 2-s2.0-0028012276 01/13/1994       26 Citations
  • Anti-ischaemic actions of potassium channel openers in experimental myocardial ischaemia/reperfusion injury in dogs. (Auchampach JA, Gross GJ) Eur Heart J 1993 Jul;14 Suppl B:10-5 PMID: 8370365 SCOPUS ID: 2-s2.0-0027291527 07/01/1993       30 Citations
  • Adenosine A1 receptors, KATP channels, and ischemic preconditioning in dogs. (Auchampach JA, Gross GJ) Am J Physiol 1993 May;264(5 Pt 2):H1327-36 PMID: 8498546 SCOPUS ID: 2-s2.0-0027297849 05/01/1993       327 Citations
  • Cardioprotective effects of monophosphoryl lipid A, a novel endotoxin analogue, in the dog. (Yao Z, Auchampach JA, Pieper GM, Gross GJ) Cardiovasc Res 1993 May;27(5):832-8 PMID: 8394211 SCOPUS ID: 2-s2.0-85047677864 05/01/1993       78 Citations
  • Relationship of severity of myocardial stunning to ATP dependent potassium channel modulation. (Warltier DC, Auchampach JA, Gross GJ) J Card Surg 1993 Mar;8(2 Suppl):279-83 PMID: 8461517 SCOPUS ID: 2-s2.0-0027523308 03/01/1993       12 Citations
  • Blockade of ischaemic preconditioning in dogs by the novel ATP dependent potassium channel antagonist sodium 5-hydroxydecanoate. (Auchampach JA, Grover GJ, Gross GJ) Cardiovasc Res 1992 Nov;26(11):1054-62 PMID: 1291082 SCOPUS ID: 2-s2.0-85047677669 11/01/1992       258 Citations
  • Role of ATP dependent potassium channels in myocardial ischaemia. (Gross GJ, Auchampach JA) Cardiovasc Res 1992 Nov;26(11):1011-6 PMID: 1291076 SCOPUS ID: 2-s2.0-85047679140 11/01/1992       121 Citations
  • Pharmacological evidence for a role of ATP-dependent potassium channels in myocardial stunning. (Auchampach JA, Maruyama M, Cavero I, Gross GJ) Circulation 1992 Jul;86(1):311-9 PMID: 1301066 SCOPUS ID: 2-s2.0-0026748339 07/01/1992       169 Citations
  • Blockade of ATP-sensitive potassium channels prevents myocardial preconditioning in dogs. (Gross GJ, Auchampach JA) Circ Res 1992 Feb;70(2):223-33 PMID: 1310443 SCOPUS ID: 2-s2.0-0026547286 02/01/1992       907 Citations
  • Cardioprotective effects of nicorandil. (Gross GJ, Auchampach JA, Maruyama M, Warltier DC, Pieper GM) J Cardiovasc Pharmacol 1992;20 Suppl 3:S22-8 PMID: 1282172 SCOPUS ID: 2-s2.0-0026641143 01/01/1992       80 Citations
  • Nicorandil attenuates myocardial dysfunction associated with transient ischemia by opening ATP-dependent potassium channels. (Auchampach JA, Cavero I, Gross GJ) J Cardiovasc Pharmacol 1992;20(5):765-71 PMID: 1280739 SCOPUS ID: 2-s2.0-0026648690 01/01/1992       95 Citations
  • The new K+ channel opener Aprikalim (RP 52891) reduces experimental infarct size in dogs in the absence of hemodynamic changes. (Auchampach JA, Maruyama M, Cavero I, Gross GJ) J Pharmacol Exp Ther 1991 Dec;259(3):961-7 PMID: 1762089 SCOPUS ID: 2-s2.0-0026346285 12/01/1991       120 Citations
  • Last update: 12/04/2019
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