Medical College of Wisconsin
CTSICores SearchResearch InformaticsREDCap

John Chan PhD

John Chan PhD

Assistant Professor

Institution: Medical College of Wisconsin
Department: Cell Biology, Neurobiology and Anatomy
Program: Administration

Member of the Cancer Center


  • Structure-activity profiling of alkaloid natural product pharmacophores against a Schistosoma serotonin receptor. (Marchant JS, Harding WW, Chan JD) Int J Parasitol Drugs Drug Resist 2018 12;8(3):550-558 PMID: 30297303 PMCID: PMC6287472 10/10/2018       1 Citations
  • Coalescing beneficial host and deleterious antiparasitic actions as an antischistosomal strategy. (Chan JD, Day TA, Marchant JS) Elife 2018 07 30;7 PMID: 30059006 PMCID: PMC6095690 07/31/2018    
  • Unique pharmacological properties of serotoninergic G-protein coupled receptors from cestodes. (Camicia F, Celentano AM, Johns ME, Chan JD, Maldonado L, Vaca H, Di Siervi N, Kamentezky L, Gamo AM, Ortega-Gutierrez S, Martin-Fontecha M, Davio C, Marchant JS, Rosenzvit MC) PLoS Negl Trop Dis 2018 02;12(2):e0006267 PMID: 29425245 PMCID: PMC5823469 02/10/2018       4 Citations
  • The anthelmintic praziquantel is a human serotoninergic G-protein-coupled receptor ligand. (Chan JD, Cupit PM, Gunaratne GS, McCorvy JD, Yang Y, Stoltz K, Webb TR, Dosa PI, Roth BL, Abagyan R, Cunningham C, Marchant JS) Nat Commun 2017 12 05;8(1):1910 PMID: 29208933 PMCID: PMC5716991 12/07/2017       13 Citations
  • Dataset for a de novo transcriptome assembly, utilized for defining the voltage-gated like ion channel superfamily. (Chan JD, Zhang D, Liu X, Zarowiecki MZ, Berriman M, Marchant JS) Data Brief 2016 Dec;9:1044-1047 PMID: 27909700 PMCID: PMC5124351 12/03/2016    
  • Utilizing the planarian voltage-gated ion channel transcriptome to resolve a role for a Ca channel in neuromuscular function and regeneration. (Chan JD, Zhang D, Liu X, Zarowiecki M, Berriman M, Marchant JS) Biochim Biophys Acta Mol Cell Res 2017 Jun;1864(6):1036-1045 PMID: 27771293 PMCID: PMC5397384 10/25/2016       1 Citations
  • Kinetic profiling an abundantly expressed planarian serotonergic GPCR identifies bromocriptine as a perdurant antagonist. (Chan JD, Grab T, Marchant JS) Int J Parasitol Drugs Drug Resist 2016 12;6(3):356-363 PMID: 27397764 PMCID: PMC5196488 07/12/2016       7 Citations
  • Pharmacological profiling an abundantly expressed schistosome serotonergic GPCR identifies nuciferine as a potent antagonist. (Chan JD, Acharya S, Day TA, Marchant JS) Int J Parasitol Drugs Drug Resist 2016 12;6(3):364-370 PMID: 27397763 PMCID: PMC5196489 07/12/2016       8 Citations
  • A Miniaturized Screen of a Schistosoma mansoni Serotonergic G Protein-Coupled Receptor Identifies Novel Classes of Parasite-Selective Inhibitors. (Chan JD, McCorvy JD, Acharya S, Johns ME, Day TA, Roth BL, Marchant JS) PLoS Pathog 2016 05;12(5):e1005651 PMID: 27187180 PMCID: PMC4871480 05/18/2016       13 Citations
  • Ergot Alkaloids (Re)generate New Leads as Antiparasitics. (Chan JD, Agbedanu PN, Grab T, Zamanian M, Dosa PI, Day TA, Marchant JS) PLoS Negl Trop Dis 2015;9(9):e0004063 PMID: 26367744 PMCID: PMC4569474 09/15/2015       10 Citations
  • Making heads or tails: planarian stem cells in the classroom. (Srougi MC, Thomas-Swanik J, Chan JD, Marchant JS, Carson S) J Microbiol Biol Educ 2014 May;15(1):18-25 PMID: 24839511 PMCID: PMC4004734 05/20/2014    
  • 'Death and axes': unexpected Ca²⁺ entry phenologs predict new anti-schistosomal agents. (Chan JD, Agbedanu PN, Zamanian M, Gruba SM, Haynes CL, Day TA, Marchant JS) PLoS Pathog 2014 Feb;10(2):e1003942 PMID: 24586156 PMCID: PMC3930560 03/04/2014       17 Citations
  • Characterization of a flatworm inositol (1,4,5) trisphosphate receptor (IP₃R) reveals a role in reproductive physiology. (Zhang D, Liu X, Chan JD, Marchant JS) Cell Calcium 2013 May-Jun;53(5-6):307-14 PMID: 23481272 PMCID: PMC3665645 03/14/2013    
  • Ca²⁺ channels and praziquantel: a view from the free world. (Chan JD, Zarowiecki M, Marchant JS) Parasitol Int 2013 Dec;62(6):619-28 PMID: 23246536 PMCID: PMC3610807 12/19/2012       16 Citations
  • Opposing roles of voltage-gated Ca2+ channels in neuronal control of regenerative patterning. (Zhang D, Chan JD, Nogi T, Marchant JS) J Neurosci 2011 Nov 02;31(44):15983-95 PMID: 22049441 PMCID: PMC3380623 11/04/2011       22 Citations
  • Pharmacological and functional genetic assays to manipulate regeneration of the planarian Dugesia japonica. (Chan JD, Marchant JS) J Vis Exp 2011 Aug 31(54) PMID: 21897362 PMCID: PMC3217636 09/08/2011       7 Citations
  • A novel biological activity of praziquantel requiring voltage-operated Ca2+ channel beta subunits: subversion of flatworm regenerative polarity. (Nogi T, Zhang D, Chan JD, Marchant JS) PLoS Negl Trop Dis 2009 Jun 23;3(6):e464 PMID: 19554083 PMCID: PMC2694594 06/26/2009       65 Citations
  • Last update: 10/11/2018
    jenkins-FCD Prod-297 dff1a717c492f00bf6291286365f1f4fe95208f1